A skin care composition and a preparation method thereof

By developing a skin care composition containing natural ingredients such as macadamia nut oil, the problem of insufficient sedation and repair of sensitive skin has been solved, and efficient skin repair and anti-inflammatory effects have been achieved, which is suitable for a wide range of sensitive skin needs.

CN115969748BActive Publication Date: 2025-05-30AGRI PRODS PROCESSING RES INST CHINESE ACAD OF TROPICAL AGRI SCI +1
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Patent Information

Application Number
CN202211732905.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-12-30
Publication Date
2025-05-30
Estimated Expiration
2042-12-30

AI Technical Summary

Technical Problem

Existing skin care products have poor sedation and repair of sensitive skin and often contain irritating ingredients, which can easily cause allergic reactions and are difficult to meet a wide range of sensitive skin needs.

Method used

Develop a skin care composition mainly composed of natural ingredients, including macadamia oil, red pomegranate extract, aqueous macadamia extract and oil olive leaf extract, etc., and combine these ingredients through efficient preparation methods to form skin care products with strong permeability and anti-inflammatory properties.

Benefits of technology

The skin care composition can significantly calm and repair sensitive skin, reduce allergic reactions, improve skin resistance, and is more safe due to the use of natural ingredients, and is suitable for a wide range of sensitive skin.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present invention discloses a skin care composition and a preparation method thereof. The skin care composition comprises active components by weight: 18 - 40 parts of macadamia nut oil; 1 - 4 parts of moringa leaves; 2 - 5 parts of plant extract; 5 - 13 parts of auxiliary agent. The preparation method includes: prefabrication step: dissolving moringa leaf powder with a solvent, adding macadamia nut oil thereto, shearing with a high-speed disperser at 8000 - 10000 r / min for 3 - 5 min, and then treating with a super high-pressure microfluidizer at a pressure of 100 MPa to obtain a moringa leaf emulsion; mixing step: dissolving the plant extract and the auxiliary agent with a solvent, and then adding them into the moringa leaf emulsion to obtain the skin care composition. The skin care composition is mainly composed of natural ingredients. Compared with traditional skin care products, it has higher safety performance, is mild and non-irritating, is less likely to cause skin allergies, and the natural ingredients are more easily absorbed by the skin, making the calming and repairing effect of the product more remarkable; and it has more prominent functionality.
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Description

Technical Field

[0001] The present invention relates to a skin care composition and a preparation method thereof, belonging to the technical field of functional skin products. Background Art

[0002] Sensitive skin is an abnormal damaged state of the skin. The skin is damaged, so it is incomplete and unhealthy, with poor resistance to various external stimulating factors, and is prone to flushing, swelling, itching or even stinging under normal stimulation. In severe cases, there is also red blood streak dilation.

[0003] If sensitive skin is not properly repaired and protected, frequent sensitive reactions will occur: inflammatory factors involved in sensitive reactions will accumulate in the body. When stimulated again next time, the inflammatory factors will be quickly activated, and the sensitive condition will become more serious, forming a vicious cycle, which will be difficult to control in the long run.

[0004] There are many skin care products on the market, but there are few skin care products suitable for sensitive skin. It should be said that some additives in ordinary skin care products are a kind of stimulation to sensitive skin. Therefore, it is necessary to develop a skin care product that is suitable for many sensitive skins. Summary of the Invention

[0005] In order to overcome the deficiencies of the prior art, the first object of the present invention is to provide a skin care composition, which has natural ingredients, is suitable for calming and repairing sensitive skin, and has strong permeability.

[0006] The second object of the present invention is to provide a preparation method of the above skin care composition.

[0007] The first object of the present invention can be achieved by adopting the following technical solutions: A skin care composition, comprising the following active components by weight:

[0008]

[0009] Further, it comprises the following active components by weight:

[0010]

[0011] Further, the plant extract includes at least one of pomegranate extract, aqueous macadamia nut extract and olive leaf extract.

[0012] Further, the auxiliary agent includes at least one of a humectant, a thickener, an emulsifier, an antioxidant, an anti-inflammatory agent and a preservative.

[0013] Further, the emulsifier is at least one of beeswax and arachidyl alcohol.

[0014] Furthermore, the antioxidant is at least one of a radix strychnifoliae extract and glycyrrhizin isoflavones.

[0015] Furthermore, the anti-inflammatory agent is at least one of a gorgonian extract and a licorice extract.

[0016] Furthermore, the preservative is at least one of tea polyphenols and tea tree essential oil.

[0017] Furthermore, the moisturizing agent is at least one of hydrolyzed hyaluronic acid, acetylated sodium hyaluronate and sodium hyaluronate cross-linked polymer.

[0018] Furthermore, the thickener is at least one of carbomer, gum arabic and konjac gum.

[0019] The second object of the present invention can be achieved by adopting the following technical scheme: a method for preparing the skin care composition as described above, comprising:

[0020] Pre-preparation step: dissolving Moringa leaf powder with a solvent, adding macadamia nut oil, shearing with a high-speed disperser at 8000-10000 r / min for 3-5 minutes, and then treating with ultra-high pressure microfluidization at a pressure of 100 MPa to obtain Moringa leaf emulsion;

[0021] Mixing step: dissolving the plant extract and the auxiliary agent with a solvent, and then adding them into the Moringa leaf emulsion to obtain a skin care composition.

[0022] Furthermore, macadamia nut oil is prepared by the following method: macadamia nut kernels are dried at 50-60° C. to a moisture content of less than 5wt% and then crushed, 30-50% v / v ethanol solution is added, and then 1-3wt% bromelain is added, ultrasonic extraction is performed at 30-50° C. and then centrifuged, and the top oil phase is taken as macadamia nut oil.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] 1. The skin care composition of the present invention is a soothing and repairing skin care product suitable for sensitive skin, developed based on the characteristics of macadamia nut oil itself and the efficacy of its ingredients; macadamia nut oil is mild and non-irritating, has strong permeability, and has anti-inflammatory properties, making the skin care product easier to be absorbed by the skin and less likely to cause allergies;

[0025] 2. The skin care composition of the present invention is mainly composed of natural ingredients. Compared with traditional skin care products, it has higher safety performance, is mild and non-irritating, is less likely to cause skin allergies, and the natural ingredients are more easily absorbed by the skin, making the product's calming and repairing effect more significant; the functionality is more prominent;

[0026] 3. The preparation method of the present invention is simple and efficient, can maximize the characteristics of the ingredients, and is suitable for industrial production. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 Bar chart of the ABTS free radical scavenging rate of the test examples;

[0028] Figure 2 Bar chart of the DPPH free radical scavenging rate of the test examples;

[0029] Figure 3 Bar chart of the total reducing power of the test examples. Detailed implementation manners

[0030] Next, in combination with the accompanying drawings and specific implementation manners, the present invention will be further described:

[0031] A skin care composition, comprising the following active components by weight:

[0032]

[0033] Macadamia oil contains the nutrients necessary for the skin to form an oil protection layer, and has a mild oiliness and does not irritate the skin; it can make the skin soft and energetic, protect cell membranes and moisturize, etc. Most importantly, it is rich in a very special functional fatty acid - palmitoleic acid, accounting for about 20% of the total fatty acid content, which is an Omega-7 monounsaturated fatty acid. This fatty acid can promote cell metabolism and keep the skin moisturized; it has strong skin permeability and can reach the deep layer of the skin to moisturize the skin and make it smooth; in addition, Omega-7 fatty acid has a strong inhibitory effect on melanin production and has a good whitening effect; it also has significant anti-inflammatory activity.

[0034] Among them, the plant extract includes at least one of pomegranate extract, aqueous macadamia extract and olive leaf extract.

[0035] Among them, the auxiliaries include a humectant, a thickener, an emulsifier, an antioxidant, an anti-inflammatory agent and a preservative.

[0036] Among them, the emulsifier is at least one of beeswax and arachidyl alcohol.

[0037] Among them, the antioxidant is at least one of Lysimachia christinae extract and licorice isoflavone.

[0038] Among them, the anti-inflammatory agent is at least one of gorgonian extract and licorice extract.

[0039] Among them, the preservative is at least one of tea polyphenols and tea tree essential oil.

[0040] Among them, the humectant is at least one of hydrolyzed hyaluronic acid, sodium acetylated hyaluronate and sodium hyaluronate cross-linked polymer.

[0041] Among them, the thickener is at least one of carbomer, gum arabic and konjac gum.

[0042] The soothing and anti-inflammatory ingredients derived from natural plants are contained therein, with as few or no allergens and irritants as possible, mainly composed of natural ingredients. Compared with traditional skin care products, it has higher safety performance, is mild and non-irritating, is less likely to cause skin allergies, and the natural ingredients are more easily absorbed by the skin, making the sedative and repair effect of the product more significant; the functionality is more prominent.

[0043] The preparation method of the skin care composition includes:

[0044] The preparation steps of macadamia nut oil: The macadamia nuts are dried at 50 - 60 °C for 10 - 12 h until the moisture content is below 5 wt%, then crushed, added with 30 - 50% v / v ethanol solution according to the solid-liquid ratio of 1:3 - 5, and then added with 1 - 3 wt% bromelain, ultrasonically extracted at 30 - 50 °C with a power of 500 W for 1 - 2 h, and then centrifuged at 8000 - 10000 r / min for 10 - 15 min. The top layer of the oil phase is taken as macadamia nut oil; the ethanol in the middle layer is removed by rotary evaporation to obtain the aqueous macadamia nut extract; this method is simple and easy to operate, has a high oil extraction rate, no solvent pollution, and the extracted macadamia nut oil has high purity, good quality, and retains more active substances at low temperature;

[0045] The preparation steps of moringa leaf powder: Select fresh moringa leaves, freeze-dry them at -85 °C for 48 h, and then crush them with a pulverizer and pass through a 300-mesh sieve to obtain moringa leaf powder;

[0046] The prefabrication step: Dissolve the moringa leaf powder in deionized water, stir evenly, filter to remove impurities with a filter bag, add macadamia nut oil, shear at 8000 - 10000 r / min with a high-speed disperser for 3 - 5 min, and then treat with a high-pressure microfluidizer at a pressure of 100 MPa for 5 min to obtain moringa leaf emulsion;

[0047] The mixing step: Add the humectant to deionized water and stir until it is completely dissolved; add the thickener to deionized water, heat and stir until it is completely dissolved; mix the humectant solution and the thickener solution, then add the emulsifier, plant extract, antioxidant, anti-inflammatory agent, preservative, and the remaining water. After all the ingredients are completely dissolved, add the moringa leaf emulsion and stir evenly, and let it stand for 24 h to obtain the skin care composition.

[0048] The skin care composition is in a gel state, formed by the mutual connection of colloidal particles or polymers in the solution under certain conditions to form a spatial network structure, and the structure voids are filled with the liquid as the dispersion medium. It has super skin permeability, can make the active ingredients reach the deep layer of the skin directly, and in addition, it has a cooling and calming effect, and its cool feeling can make the blood circulation normal and soothe and calm the swelling caused by allergies.

[0049] Example 1:

[0050] A skin care composition, comprising active components by weight as shown in Table 1:

[0051] Table 1 Components of the skin care composition in Example 1

[0052]

[0053] The preparation method of the skin care composition includes:

[0054] The preparation steps of macadamia nut oil: The macadamia nut kernels are dried at 50 °C for 12 h until the moisture content is below 5 wt%, then crushed, added with 35% v / v ethanol solution according to the solid-liquid ratio of 1:3, and then added with 1.5 wt% bromelain, and ultrasonically extracted at 46 °C for 2 h at a power of 500 W, and then centrifuged at 10000 r / min for 10 min, and the uppermost oil phase is taken as macadamia nut oil; the ethanol in the middle layer is removed by rotary evaporation to obtain the aqueous-phase macadamia nut extract;

[0055] The preparation steps of moringa leaf powder: Select fresh moringa leaves, freeze-dry them at -85 °C for 48 h, then crush them with a pulverizer and pass through a 300-mesh sieve to obtain moringa leaf powder;

[0056] The prefabrication steps: Dissolve the moringa leaf powder in deionized water, stir evenly, filter to remove impurities with a filter bag, add macadamia nut oil, shear at 8000 r / min with a high-speed disperser for 5 min, and then treat with a high-pressure microfluidizer at a pressure of 100 MPa for 5 min for a total of three times to obtain a moringa leaf emulsion;

[0057] The mixing steps: Add the humectant to deionized water and stir until it is completely dissolved; add the thickener to deionized water, heat and stir until it is completely dissolved; mix the humectant solution and the thickener solution, then add the emulsifier, plant extract, antioxidant, anti-inflammatory agent, preservative, and the remaining water. After all components are completely dissolved, add the moringa leaf emulsion and stir evenly, and let it stand for 24 h to obtain the skin care composition.

[0058] Example 2:

[0059] A skin care composition, comprising active components by weight as shown in Table 2:

[0060] Table 2 Components of the skin care composition in Example 2

[0061]

[0062]

[0063] The preparation method of the skin care composition includes:

[0064] Preparation steps of macadamia nut oil: The macadamia nut kernels are dried at 60 °C for 10 h until the moisture content is below 5 wt%, then crushed, added with 40% v / v ethanol solution according to a solid-liquid ratio of 1:4, and then added with 2 wt% bromelain. Ultrasonic extraction is carried out at 40 °C with a power of 500 W for 1.5 h, and then centrifuged at 9000 r / min for 12 min. The top oil phase is taken as macadamia nut oil; the ethanol in the middle layer is removed by rotary evaporation to obtain the aqueous macadamia nut extract;

[0065] Preparation steps of moringa leaf powder: Select fresh moringa leaves, freeze-dry them at -85 °C for 48 h, then crush them with a pulverizer and pass through a 300-mesh sieve to obtain moringa leaf powder;

[0066] Pre-preparation step: Dissolve the moringa leaf powder in deionized water, stir evenly, filter to remove impurities with a filter bag, add macadamia nut oil, shear at 9000 r / min with a high-speed disperser for 4 min, and then treat with a high-pressure microfluidizer at a pressure of 100 MPa for 5 min for a total of three times to obtain a moringa leaf emulsion;

[0067] Mixing step: Add a moisturizer to deionized water and stir until it is completely dissolved; add a thickener to deionized water, heat and stir until it is completely dissolved; mix the moisturizer solution and the thickener solution, then add an emulsifier, a plant extract, an antioxidant, an anti-inflammatory agent, a preservative, and the remaining water. After all components are completely dissolved, add the moringa leaf emulsion and stir evenly, and let it stand for 24 h to obtain a skin care composition.

[0068] Example 3:

[0069] A skin care composition, comprising effective components by weight as shown in Table 3:

[0070] Table 3 Components of the skin care composition in Example 3

[0071]

[0072]

[0073] The preparation method of the skin care composition includes:

[0074] Preparation steps of macadamia nut oil: The macadamia nut kernels are dried at 55 °C for 11 h until the moisture content is below 5 wt%, then crushed, added with 50% v / v ethanol solution according to a solid-liquid ratio of 1:3.5, and then added with 3 wt% bromelain. Ultrasonic extraction is carried out at 50 °C with a power of 500 W for 1 h, and then centrifuged at 9500 r / min for 10 min. The top oil phase is taken as macadamia nut oil; the ethanol in the middle layer is removed by rotary evaporation to obtain the aqueous macadamia nut extract;

[0075] Preparation steps of moringa leaf powder: Select fresh moringa leaves, freeze-dry them at -85°C for 48 hours, then crush them with a pulverizer and pass through a 300-mesh sieve to obtain moringa leaf powder;

[0076] Pre-preparation step: Dissolve moringa leaf powder in deionized water, stir evenly, filter to remove impurities with a filter bag, add macadamia nut oil, shear it at 9500 r / min with a high-speed disperser for 3 minutes, and then process it three times with a super high-pressure microfluidizer at a pressure of 100 MPa for 5 minutes each time to obtain a moringa leaf emulsion;

[0077] Mixing step: Add a moisturizer to deionized water and stir until it is completely dissolved; add a thickener to deionized water, heat and stir until it is completely dissolved; mix the moisturizer solution and the thickener solution, then add an emulsifier, a plant extract, an antioxidant, an anti-inflammatory agent, a preservative, and the remaining water. After all components are completely dissolved, add the moringa leaf emulsion and stir evenly, then let it stand for 24 hours to obtain a skin care composition.

[0078] Example 4:

[0079] A skin care composition, comprising active components shown in Table 4 by weight:

[0080] Table 4 Components of the skin care composition in Example 4

[0081]

[0082]

[0083] A preparation method of the skin care composition, comprising:

[0084] Preparation steps of macadamia nut oil: Dry macadamia nuts at 58°C for 10.5 hours until the moisture content is below 5 wt%, then crush them, add a 30% v / v ethanol solution according to a solid-liquid ratio of 1:4.5, add 1 wt% bromelain, extract ultrasonically at a power of 500 W at 30°C for 1.8 hours, then centrifuge at a speed of 8500 r / min for 13 minutes, and take the top oil phase as macadamia nut oil; Evaporate the ethanol from the middle layer by rotary evaporation to obtain the aqueous macadamia nut extract;

[0085] Preparation steps of moringa leaf powder: Select fresh moringa leaves, freeze-dry them at -85°C for 48 hours, then crush them with a pulverizer and pass through a 300-mesh sieve to obtain moringa leaf powder;

[0086] Pre-preparation step: Dissolve moringa leaf powder in deionized water, stir evenly, filter to remove impurities with a filter bag, add macadamia nut oil, shear it at 10000 r / min with a high-speed disperser for 3 minutes, and then process it three times with a super high-pressure microfluidizer at a pressure of 100 MPa for 5 minutes each time to obtain a moringa leaf emulsion;

[0087] Mixing step: Add the moisturizer to deionized water and stir until it is completely dissolved; add the thickener to deionized water, heat and stir until it is completely dissolved; mix the moisturizer solution and the thickener solution, then add the emulsifier, plant extract, antioxidant, anti-inflammatory agent, preservative, and the remaining water. After all the components are completely dissolved, add the moringa leaf emulsion and stir evenly. Let it stand for 24 h to obtain the skin care composition.

[0088] Example 5:

[0089] A skin care composition, comprising the active components shown in Table 5 by weight:

[0090] Table 5 Components of the Skin Care Composition in Example 5

[0091]

[0092] The preparation method of the skin care composition includes:

[0093] The preparation steps of macadamia nut oil: The macadamia nut kernels are dried at 52 °C for 11.5 h until the moisture content is below 5 wt%, then crushed. Add 45% v / v ethanol solution according to the solid-liquid ratio of 1:5, and then add 2.5 wt% bromelain. Ultrasonic extract at 37 °C with a power of 500 W for 1.2 h, then centrifuge at 8000 r / min for 15 min. Take the top oil phase as macadamia nut oil; the ethanol in the middle layer is removed by rotary evaporation to obtain the aqueous macadamia nut extract;

[0094] The preparation steps of moringa leaf powder: Select fresh moringa leaves, freeze-dry them at -85 °C for 48 h, then crush them with a pulverizer and pass through a 300-mesh sieve to obtain moringa leaf powder;

[0095] Pre-preparation step: Dissolve the moringa leaf powder in deionized water and stir evenly, filter out impurities with a filter bag, add macadamia nut oil, shear at 8500 r / min with a high-speed disperser for 4 min, and then process with a super high-pressure microfluidizer at a pressure of 100 MPa for 5 min for a total of three times to obtain the moringa leaf emulsion;

[0096] Mixing step: Add the moisturizer to deionized water and stir until it is completely dissolved; add the thickener to deionized water, heat and stir until it is completely dissolved; mix the moisturizer solution and the thickener solution, then add the emulsifier, plant extract, antioxidant, anti-inflammatory agent, preservative, and the remaining water. After all the components are completely dissolved, add the moringa leaf emulsion and stir evenly. Let it stand for 24 h to obtain the skin care composition.

[0097] Detection of skin improvement:

[0098] A total of 60 subjects were selected, aged between 18 and 50, numbered from 1 to 60. In terms of skin sensitivity, the proportion of mildly sensitive skin is the largest, followed by moderately sensitive skin. The main skin problems of the testers are skin flushing, fragility and itching, skin tightness, dryness and roughness, peeling, acne, etc. The subjects used the test products once in the morning, noon, and evening. Before use, clean the skin first, and then gently apply the product to the facial skin. Among them, subjects numbered 1 - 10 used the product of Example 1, those numbered 11 - 20 used the product of Example 2, those numbered 21 - 30 used the product of Example 3, those numbered 31 - 40 used the product of Example 4, those numbered 41 - 50 used the product of Example 5, and those numbered 51 - 60 used a commercially available product for sensitive skin. During the product trial period, the subjects considered that the moisturizing and hydrating effects of the examples were more obvious, the skin feeling was cool, and it had a good sedative effect on skin swelling. Among them, the effect of Example 5 was the most obvious; after 14 days of trial, there were obvious improvements in aspects such as dry peeling, skin flushing, moisture and elasticity, and skin texture stability; after 28 days of trial, most people thought that the product had a practical effect of soothing and calming the skin. After one month of the experiment, the comprehensive effects of the facial skin of the subjects were evaluated. It was found that the subjects using the products of the examples did not show skin adverse reactions, and their facial skin had obvious effects of moisturizing and repairing, improving skin texture, whitening and brightening the skin, and fading acne marks, with Example 5 taking effect the fastest; the subjects using the commercially available products did not show skin adverse reactions, and their facial skin had a certain effect of moisturizing the skin, but the effect of skin improvement was not obvious.

[0099] Detection of allergic conditions:

[0100] Skin allergy is a hypersensitivity reaction of the body, an abnormal reaction of a person to normal substances (allergens). Allergies occur when allergens come into contact with people with allergic constitutions. Allergens include pollen, dust, foreign proteins, chemical substances, ultraviolet rays, etc. In the process of the occurrence of allergic reactions, allergic mediators play a direct role. Allergens are the external causes of allergic diseases, while low immune ability of the body and oxidative damage of a large number of free radicals to cells are the internal causes of allergies. The main symptoms of skin allergy are swelling, itching, fever, stinging, peeling, etc.

[0101] The external symptoms of skin allergy are "swelling, fever, pain", and its symptoms are similar to those of inflammation. Therefore, the anti-inflammatory efficacy of skin care compositions can be evaluated through anti-inflammatory experiments; the internal cause of skin allergy is the oxidative damage of free radicals to cells. Therefore, the repair efficacy of skin care compositions can be evaluated through the test of antioxidant performance. The specific data are as follows:

[0102] The anti-inflammatory and repair effects of the skin care composition were evaluated through the mouse ear swelling experiment: 60 healthy mice, half male and half female, were randomly divided into 6 groups, with 10 mice in each group. The hair on the left and right auricles of each group of mice was carefully shaved, and the skin preparation area was about 2 cm × 2 cm. The left ear was the experimental area, and the right ear was the reference area. The left auricle of the mice was modeled. 0.1 mL of normal saline and 0.1 mL of pimecrolimus were applied to the shaved areas of the left ears of the mice in the negative control group and the positive control group, respectively. Example 5 was used as the basis to set up Test Examples 1-4, which contained macadamia oil and moringa leaf components in proportions of 40%, 30%, 20%, 10%, and 0% as shown in Table 6:

[0103] Table 6 Components of the Skin Care Composition in Test Examples

[0104]

[0105] The mice in the test examples and the blank group were respectively given 0.1 mL of the skin care composition at the corresponding concentration. After 24 h, 0.05 mL of 5 wt% DNCB acetone solution was applied to the shaved areas of the left ears of each group of mice to sensitize them. After 24 h, the same dose of 5 wt% DNCB acetone solution was given again to enhance the sensitization effect. 1 h after administration on the 3rd day, a sensitization attack was performed on each group of mice. The method was to evenly apply 10 μL of 5 wt% DNCB acetone solution on both sides of the left auricle. After 1 h of application, the mice were sacrificed. Samples were taken from symmetrical parts of the left and right ears of the mice with a puncher with a diameter of 8 mm, weighed, and the swelling degree (mg) and inhibition rate (%) were calculated. The experimental results are shown in Table 7.

[0106] Swelling degree = weight of left ear - weight of right ear

[0107] Swelling inhibition rate % = [(swelling degree of normal saline group - swelling degree of each administration group) / swelling degree of normal saline group] × 100%

[0108] Table 7 Results of the Mouse Ear Swelling Experiment of the Sedative and Repair Skin Care Gel

[0109] Group Swelling degree (mg) Inhibition rate (%) Negative control group (saline) 16.33±2.39 — Positive control group (pimecrolimus) 6.15±2.25** 62.34 Test case 1 6.26±4.16* 61.67 Test case 3 9.43±4.54 42.25 Test case 4 11.27±3.58 30.99 Test case 5 13.62±4.21 16.60

[0110] Note: Compared with the negative control group: **P < 0.01, *P < 0.05

[0111] As can be seen from Table 7, compared with the negative control group, each administration group had a certain inhibitory effect on mouse ear swelling. There were significant differences between the test examples and the positive control group, but they could all reduce the mouse ear swelling degree and had a very significant anti-inflammatory effect. As the macadamia oil and moringa leaf in the test examples decreased, their anti-inflammatory effects also decreased significantly. In Test Example 5, due to the presence of other anti-inflammatory components, it also had a certain anti-inflammatory effect, but its effect was only a little better than that of the negative control group.

[0112] Detection of antioxidant properties:

[0113] Figures 1 - 3 The scavenging rates of the test examples for ABTS free radicals and DPPH free radicals are different, and the total reducing power is also different. Specifically, from Figure 1 , Figure 2 it can be seen that as the macadamia nut oil and moringa leaves increase, the scavenging rates of the test example products for ABTS free radicals and DPPH free radicals increase accordingly, indicating that macadamia nut oil and moringa leaves have good scavenging rates for ABTS free radicals and DPPH free radicals. From Figure 3 it can be seen that as the macadamia nut oil and moringa leaves increase, the total reducing power of the product also increases. The stronger the reducing ability, the stronger the antioxidant property, indicating that macadamia nut oil and moringa leaves have good antioxidant properties. The products without macadamia nut oil and moringa leaves also contain some plant extracts with antioxidant properties, and their scavenging rates for ABTS free radicals and DPPH free radicals and total reducing power are also higher than those of commercially available products.

[0114] For those skilled in the art, various corresponding changes and deformations can be made according to the technical solutions and concepts described above, and all these changes and deformations should fall within the protection scope of the claims of the present invention.

Claims

1. A skin care composition, comprising the following components by weight: 36.5 parts of macadamia oil; 3.5 parts of moringa leaves; Plant extracts: 1.5 parts of olive leaf extract, 0.8 part of pomegranate extract, 1.6 parts of aqueous macadamia extract; Humectants: 0.2 part of acetylated sodium hyaluronate, 0.6 part of sodium hyaluronate cross-linked polymer; Thickeners: 0.4 part of konjac gum, 0.3 part of carbomer, 0.6 part of gum arabic; Emulsifiers: 3 parts of arachidyl alcohol, 0.5 part of beeswax; Antioxidants: 0.8 part of glabridin, 0.1 part of lysimachia christinae hance extract; Anti-inflammatory agents: 1.8 parts of licorice extract, 1.2 parts of gorgonian extract; Preservatives: 0.1 part of tea tree essential oil, 0.3 part of tea polyphenols; Solvent: 46.2 parts of deionized water; The preparation method of the skin care composition includes: The preparation step of macadamia oil: Macadamia nuts are dried at 52 °C for 11.5 h until the water content is below 5 wt%, then crushed, added with 45% v / v ethanol solution according to the solid-liquid ratio of 1:5, and then added with 2.5 wt% bromelain, and ultrasonically extracted at 37 °C with a power of 500 W for 1.2 h, and then centrifuged at 8000 r / min for 15 min, and the top oil phase is taken as macadamia oil; the ethanol in the middle layer is removed by rotary evaporation to obtain the aqueous macadamia extract; The preparation step of moringa leaf powder: Fresh moringa leaves are freeze-dried at -85 °C for 48 h, then crushed by a pulverizer and passed through a 300-mesh sieve to obtain moringa leaf powder; Pre-preparation step: Dissolve the moringa leaf powder in deionized water, stir evenly, filter to remove impurities with a filter bag, add macadamia oil, shear at 8500 r / min with a high-speed disperser for 4 min, and then treat with a super high-pressure microfluidizer at a pressure of 100 MPa for 5 min for a total of three times to obtain a moringa leaf emulsion; Mixing step: Add the humectant to deionized water and stir until completely dissolved; add the thickener to deionized water, heat and stir until completely dissolved; mix the humectant solution and the thickener solution, then add the emulsifier, plant extract, antioxidant, anti-inflammatory agent, preservative, and the remaining water. After all components are completely dissolved, add the moringa leaf emulsion and stir evenly, and let stand for 24 h to obtain the skin care composition.

Citation Information

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