An integrated brain-computer interface device and its manufacturing method and use method

Abstract

Embodiments of the present application disclose an integrated brain-computer interface device, a manufacturing method thereof, and a use method thereof, wherein the integrated brain-computer interface device includes: a first flexible substrate and a second flexible substrate bonded thereto, wherein a groove structure filled with liquid metal and a vital sign detection element are formed on the surface of the first flexible substrate opposite to the second flexible substrate, wherein the groove structure filled with liquid metal constitutes a transfer electrode in the interface transfer area, a wiring in the wiring area, and a detection electrode in the EEG signal detection electrode area; the second flexible substrate is provided with: an opening penetrating the second flexible substrate, the opening being aligned with the detection electrode, and a contact electrode in contact with the detection electrode being formed in the opening; a signal transmission component, which transmits the EEG signal and the vital sign signal detected by the contact electrode to an analyzer for analysis via the corresponding wiring in the wiring area and the corresponding transfer electrode in the interface transfer area.

Description

Technical Field

[0001] The present application relates to the field of bioelectronics technology, and more specifically, to an integrated brain-computer interface device and its manufacturing and use methods. Background Art

[0002] Brain-computer interface (BCI) technology demonstrates tremendous potential in treating brain diseases, improving the lives of people with disabilities, and enhancing and expanding brain function. Since the 1990s, research on BCIs has steadily advanced, with significant achievements in recent years. Electrodes are a crucial component of BCIs, and the development of microelectrodes with improved biocompatibility and mechanical properties more closely aligned with tissues is crucial. Furthermore, methods for minimally invasive electrode implantation are being developed to enable long-term, stable, and safe recording and regulation of neuronal activity.

[0003] Traditional brain-computer interface electrodes are generally made of rigid materials such as silicon, stainless steel, gold, and platinum. However, intracranial implantation can cause insertion trauma and chronic foreign body reactions. There are also problems with mechanical mismatch between the microelectrode and the implanted tissue, as well as increased impedance between the microelectrode and tissue interface. This can lead to failure of the brain-computer interface during long-term implantation and may also bring risks such as tissue damage, rejection, and infection. Studies have shown that compared with rigid implant materials, flexible implants exhibit better long-term biocompatibility with biological tissues. Therefore, researchers have tried to make the base material thinner and use spraying methods to make electrodes to reduce damage to biological tissues after electrode implantation. However, this method increases the difficulty of electrode processing and does not fundamentally solve the problem of mechanical mismatch between rigid base materials and biological tissues. Summary of the Invention

[0004] In order to solve at least one of the above problems, the present application proposes an integrated brain-computer interface device and a manufacturing method and a use method thereof.

[0005] In a first aspect, the present application provides an integrated brain-computer interface device, the device comprising:

[0006] A first flexible substrate and a second flexible substrate bonded thereto, wherein:

[0007] A groove structure filled with liquid metal and a vital sign detection element are formed on a surface of the first flexible substrate opposite to the second flexible substrate, wherein the groove structure filled with liquid metal constitutes a transfer electrode in the interface transfer area, a wiring in the wiring area, and a detection electrode in the electroencephalogram signal detection electrode area, and the vital sign detection element is connected to the wiring in the wiring area to achieve transmission of vital sign signals detected by the vital sign detection element;

[0008] The second flexible substrate is provided with: an opening penetrating the second flexible substrate, the opening being aligned with the detection electrode, and a contact electrode in contact with the detection electrode being formed in the opening;

[0009] The signal transmission component transmits the brain electrical signal detected by the contact electrode and the vital sign signal to the analyzer for analysis via the corresponding wiring in the wiring area and the corresponding adapter electrodes in the interface adapter area.

[0010] In a specific embodiment, the signal transmission component is a flexible tubular structure filled with the liquid metal, a first port of which is connected to the first flexible substrate and connected to the groove structure filled with liquid metal, and a second port is connected to the analyzer.

[0011] In a specific embodiment, the shape of the second port is configured to be compatible with the signal input port of the analyzer.

[0012] In a specific embodiment, the liquid metal includes at least one of elemental metal gallium, gallium-based alloys, and bismuth-based alloys, or a combination of several of them.

[0013] In a specific embodiment, the contact electrode is an inert electrode.

[0014] In a specific embodiment, the device further includes a vital sign detection element accommodating groove formed on a surface of the first flexible substrate opposite to the second flexible substrate, and the vital sign detection element is disposed in the accommodating groove.

[0015] In a specific embodiment, the vital sign detection element is a physiological saline and silicone oil solution filled in the receiving groove, and the silicone oil is suspended in the physiological saline;

[0016] The vital sign detection element and a portion of the corresponding wiring form a capacitor, thereby constituting a motion sensor.

[0017] In a specific embodiment, the vital sign detection element is a body temperature sensor or a blood oxygen sensor disposed in the accommodating groove.

[0018] In a specific embodiment, the first flexible substrate and the second flexible substrate are made of flexible materials to achieve compatibility between the brain-computer interface device and biological tissue.

[0019] In a specific embodiment, the flexible material is silicone.

[0020] In a second aspect, the present application proposes a method for manufacturing an integrated brain-computer interface device, the method comprising:

[0021] forming a first flexible substrate, wherein a groove structure and a vital sign detection element are formed on a first surface of the first flexible substrate, wherein the groove structure includes an interface adapter area, a wiring area, and an electroencephalogram signal detection electrode area;

[0022] Laying the second flexible substrate onto the first flexible substrate facing the first surface;

[0023] forming a flexible tubular connector;

[0024] Connecting the first end of the flexible tubular connector to the first flexible substrate and the groove structure to be filled with liquid metal;

[0025] Liquid metal is poured through the second end of the flexible tubular connector so that the groove structure is filled with liquid metal, thereby forming a transfer electrode in the interface transfer area, a wiring in the wiring area, and a detection electrode in the EEG signal detection electrode area, and the tubular connector is filled with liquid metal to form a signal transmission component, so as to transmit the EEG signal detected by the detection electrode and the vital sign signal detected by the vital sign detection element to the analyzer for analysis via the corresponding wiring in the wiring area, the corresponding transfer electrode in the interface transfer area, and the second end respectively;

[0026] An opening is formed through the second flexible substrate, the opening is aligned with the electrode, and a contact electrode in contact with the detection electrode is formed in the opening.

[0027] In a specific embodiment, the first flexible substrate is formed, wherein a groove structure and a vital sign detection element are formed on the first surface of the first flexible substrate, wherein the groove structure includes an interface adapter area, a wiring area, and an EEG signal detection electrode area, including:

[0028] Pour silicone into a first mold having a convex structure opposite to the groove structure to be formed, heat the first mold to solidify the silicone in the groove of the first mold, remove the silicone from the groove after solidification, and form an opening corresponding to the interface transition area.

[0029] In a specific embodiment, forming the flexible tubular connector includes:

[0030] Providing a second mold, wherein the second mold is a cavity structure including a first end plate and a second end plate, wherein the first end plate has a first opening corresponding to the transfer electrode to be formed, and the second end plate has a second opening corresponding to the signal input port of the analyzer;

[0031] placing a support core in the cavity, wherein one end of the support core extends to the first opening and the other end extends to the second opening;

[0032] The second mold is poured with silica gel from the first opening or the second opening, the second mold is heated to solidify the silica gel in the second mold, and the support core is removed from the silica gel after the silica gel is solidified.

[0033] In a third aspect, the present application proposes a method for using an integrated brain-computer interface device, the method comprising:

[0034] fixing the contact electrode to the brain;

[0035] Connect the signal transmission component to the analyzer.

[0036] The beneficial effects of this application are as follows:

[0037] This application addresses current issues in the field of brain-computer interfaces and proposes an integrated brain-computer interface device, its manufacturing method, and its use method. By using liquid metal as the detection electrode in the EEG signal detection area and wrapping the liquid metal with a flexible material, the brain-computer interface device matches the mechanical properties of biological tissue. Furthermore, a vital sign detection element is provided, and vital sign signals and EEG signals can be collected through the same interface, thereby achieving real-time monitoring of vital sign signals. The detection electrodes, signal transmission components, metal wiring, and vital sign detection elements are integrated into one, and are cast using liquid metal. The process is simple and convenient, and has broad application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0039] Figure 1 A schematic structural diagram of an integrated brain-computer interface device according to an embodiment of the present application is shown.

[0040] Figure 2 A schematic diagram of a groove structure of a first flexible substrate according to an embodiment of the present application is shown.

[0041] Figure 3 A schematic diagram showing the opening of a first end plate of a conversion electrode according to an embodiment of the present application is shown.

[0042] Figure 4 A schematic diagram showing the opening of the second end plate of the conversion electrode according to one embodiment of the present application.

[0043] Figure 5 A schematic diagram of a method for manufacturing an integrated brain-computer interface device according to an embodiment of the present application is shown.

[0044] Figure 6 A schematic diagram of an application of an integrated brain-computer interface device according to an embodiment of the present application is shown. DETAILED DESCRIPTION

[0045] To more clearly illustrate the present application, the present application is further described below in conjunction with preferred embodiments and accompanying drawings. Similar components in the accompanying drawings are represented by the same reference numerals. Those skilled in the art should understand that the specific description below is illustrative rather than restrictive and should not be used to limit the scope of protection of this application.

[0046] One embodiment of the present application proposes an integrated brain-computer interface device, such as Figure 1 As shown, the integrated brain-computer interface device includes a first flexible substrate 10 , a second flexible substrate 20 and a signal transmission component 30 , wherein the first flexible substrate 10 is bonded to the second flexible substrate 20 .

[0047] Specifically, such as Figure 2 As shown, a groove structure filled with liquid metal and a vital sign detection element 40 are formed on the surface of the first flexible substrate 10 opposite to the second flexible substrate 20, wherein the groove structure filled with liquid metal constitutes a transfer electrode 100 in the interface transfer area, a wiring in the wiring area, and a detection electrode 102 in the EEG signal detection electrode area.

[0048] It should be noted that the adapter electrodes, detection electrodes and vital sign detection elements are connected through the wiring in the wiring area to realize the detection of EEG signals and vital sign signals, wherein the vital sign detection element is connected to the wiring in the wiring area for transmitting the vital sign signals detected by the vital sign detection element, such as Figure 2 As shown, the detection electrode 102 is exemplary, which is a 6-channel detection, corresponding to 6 different brain areas of a living being, such as the motor area, the sensory area, etc.

[0049] In this embodiment, the first flexible substrate and the second flexible substrate are flexible materials with good biocompatibility, such as silicone rubber, polymer, and polydimethylsiloxane, so as to achieve compatibility between the brain-computer interface device and biological tissue.

[0050] It should be noted that the above-mentioned flexible materials are exemplary, and those skilled in the art can also select other materials as flexible materials, such as Flexdym and Ecoflex, etc., and this application does not limit this.

[0051] By adopting flexible materials, this embodiment can avoid insertion trauma and chronic foreign body reaction caused by traditional brain-computer interface electrodes made of rigid materials such as silicon, stainless steel, gold, and platinum.

[0052] This embodiment provides a fully flexible brain-computer interface device, which uses liquid metal as a conductive microelectrode and uses 3D printing technology to produce a biocompatible and soft human silicone substrate (a first flexible substrate and a second flexible substrate) to wrap the liquid metal. The fully flexible brain-computer interface device can match the implanted tissue well, solving the challenges faced by traditional brain-computer interfaces.

[0053] In this embodiment, the liquid metal includes at least one of elemental metal gallium, a gallium-based alloy, and a bismuth-based alloy, or a combination of several thereof. For example, when the liquid metal fluid contains a gallium-based alloy, the gallium-based alloy may be a gallium-indium alloy, a gallium-indium-tin alloy, or a gallium-indium-tin-zinc alloy; when the liquid metal fluid contains a bismuth-based alloy, the bismuth-based alloy may be a bismuth-indium alloy, a bismuth-indium-tin alloy, or a bismuth-indium-tin-zinc alloy. It should be noted that the above-mentioned liquid metals are exemplary, and this application does not limit the material of the liquid metal, as long as it has both metallic conductivity and fluidity.

[0054] Compared with the hard wiring in the prior art, the use of liquid metal as flexible wiring in this embodiment further enhances the compatibility of the integrated brain-computer interface device with biological tissue.

[0055] like Figure 2 As shown, the integrated interface brain-computer device further includes a vital sign detection element accommodating groove formed on a surface of the first flexible substrate opposite to the second flexible substrate, wherein the vital sign detection element 40 is disposed in the accommodating groove.

[0056] In an optional embodiment, when detecting the motion information of a living being, the vital sign detection element 40 is a physiological saline solution and a silicone oil solution filled in the accommodating groove, wherein the silicone oil solution is suspended in the physiological saline solution; the vital sign detection element and a portion of the corresponding wiring are connected to form a capacitor, thereby constituting a motion sensor.

[0057] In another optional embodiment, when detecting body temperature information or blood oxygen information of a living being, the vital sign signal and the vital sign detection element are a body temperature sensor or a blood oxygen sensor disposed in the accommodating groove.

[0058] It should be noted that the above-mentioned vital sign detection elements are exemplary, and those skilled in the art can make corresponding settings according to the detection requirements of biological sign signals, and this application does not limit this.

[0059] This example uses a vital sign detection element to acquire vital sign signals, enabling both vital sign signals and EEG signals to be collected through the same interface, enabling real-time monitoring of vital sign signals. Furthermore, by using liquid metal casting, the detection electrodes, signal transmission components, metal traces, and vital sign detection elements are integrated into one, making fabrication simple and convenient, and promising broad application prospects.

[0060] In a specific embodiment, Figure 1 As shown, the second flexible substrate 20 is provided with an opening penetrating the second flexible substrate 20 , wherein the opening is aligned with the detection electrode 102 .

[0061] Because the integrated brain-computer interface device needs to be implanted in the brain for a long time, a protective electrode needs to be placed over the detection electrode 102 to maintain its stability. To this end, a contact electrode 200 is formed in the opening to electrically contact the detection electrode 102. It should be noted that the contact electrode 200 is an inert electrode that is harmless to the living body, such as a platinum electrode.

[0062] The signal transmission component 30 in this embodiment is used to transmit the EEG signal detected by the contact electrode 200 and the vital sign signal detected by the vital sign detection element 40 to the analyzer for analysis via the corresponding wiring in the wiring area and the corresponding adapter electrodes in the interface adapter area.

[0063] In a specific example, Figure 1 As shown, the signal transmission component 30 is a flexible tubular structure filled with liquid metal, such as gallium-based metal. The first port of the signal transmission component 30 is connected to the first flexible substrate. Specifically, the first port of the signal transmission component 30 passes through the first flexible substrate 10 from the side of the first flexible substrate 10 away from the second flexible substrate 20 and is connected to the groove structure filled with liquid metal, such as the transfer electrode 100; the second port is connected to the analyzer.

[0064] In an optional embodiment, the shape of the second port is configured to be compatible with the signal input port of the analyzer, thereby reducing the use of a conversion head between the integrated brain-computer interface device and the analyzer.

[0065] In a specific manufacturing method, the steps of forming a flexible tubular structure include:

[0066] S300, providing a second mold, wherein the second mold is a cavity structure including a first end plate and a second end plate, wherein the first end plate has a first opening corresponding to the transfer electrode to be formed, and the second end plate has a second opening corresponding to the signal input port of the analyzer;

[0067] In a specific example, Figure 3 As shown, the first end plate is circular, and the first openings are the circular openings described with reference numerals 1-8, which correspond one-to-one to the switching electrodes to be formed.

[0068] like Figure 4 As shown, the second end plate is rectangular, and the second openings are square openings numbered 1'-8', corresponding to the signal input ports of the analyzer. By providing openings on the second end plate corresponding to the signal input ports of the analyzer, the need for adapters between the integrated brain-computer interface device and the analyzer can be reduced.

[0069] S302, placing a support core in the cavity, wherein one end of the support core extends to the first opening, and the other end extends to the second opening.

[0070] S304, pouring silicone into the second mold from the first opening or the second opening, heating the second mold to solidify the silicone in the second mold, and removing the support core from the silicone after the silicone is solidified.

[0071] So far, this embodiment is formed. Figure 1 The flexible tubular structure shown.

[0072] It should be noted that the signal transmission component of the above-mentioned flexible tubular structure is exemplary, and the specific shapes of the first opening and the second opening are related to the signal input port of the adapter electrode or the analyzer, and this application does not limit this.

[0073] Traditional brain-computer electrodes collect and transmit electrical signals generated by the brain, and other vital signals of the organism are difficult to collect in real time using the same interface. Based on the characteristics of full flexibility, this application integrates the detection electrodes, transmission components, analyzer interface, and vital sign detection elements of the brain-computer interface into one, and uses liquid metal to form a one-time injection molding. The processing is simple and convenient, and can realize plug-and-play between the brain-computer interface and the analyzer; at the same time, the brain-computer interface device integrates vital sign detection elements, so that EEG signals and sensor signals can be collected synchronously through the same interface, thereby realizing real-time monitoring, comparison and analysis of signals such as movement, temperature or pressure of the organism and EEG signals.

[0074] Another embodiment of the present application provides a method for manufacturing an integrated brain-computer interface device, such as Figure 5 As shown, the method includes:

[0075] S10, forming a first flexible substrate, wherein a groove structure and a vital sign detection element are formed on a first surface of the first flexible substrate, wherein the groove structure includes an interface adapter area, a wiring area, and an EEG signal detection electrode area;

[0076] S20, placing the second flexible substrate facing the first surface and laminating it to the first flexible substrate;

[0077] S30, forming a flexible tubular connector;

[0078] S40, connecting the first end of the flexible tubular connector to the first flexible substrate and the groove structure to be filled with liquid metal;

[0079] S50, pouring liquid metal through the second end of the flexible tubular connector so that the groove structure is filled with liquid metal, thereby forming a transfer electrode in the interface transfer area, a wiring in the wiring area, and a detection electrode in the EEG signal detection electrode area, and filling the tubular connector with liquid metal to form a signal transmission component, so as to transmit the EEG signals detected by the detection electrodes and the vital sign signals detected by the vital sign detection elements to the analyzer for analysis via the corresponding wiring in the wiring area, the corresponding transfer electrodes in the interface transfer area, and the second end, respectively;

[0080] S60 , forming an opening penetrating the second flexible substrate, wherein the opening is aligned with the electrode, and forming a contact electrode in contact with the detection electrode in the opening.

[0081] In a specific example, the S10 includes:

[0082] Pour silicone into a first mold having a convex structure opposite to the groove structure to be formed, heat the first mold to solidify the silicone in the groove of the first mold, remove the silicone from the groove after solidification, and form an opening corresponding to the interface transition area.

[0083] In a specific example, the S30 includes:

[0084] S300, providing a second mold, wherein the second mold is a cavity structure including a first end plate and a second end plate, wherein the first end plate has a first opening corresponding to the transfer electrode to be formed, and the second end plate has a second opening corresponding to the signal input port of the analyzer;

[0085] S302, placing a support core in the cavity, wherein one end of the support core extends to the first opening, and the other end extends to the second opening.

[0086] S304, pouring silicone into the second mold from the first opening or the second opening, heating the second mold to solidify the silicone in the second mold, and removing the support core from the silicone after the silicone is solidified.

[0087] This embodiment uses liquid metal as the detection electrode of the EEG signal detection area and wraps the liquid metal with a flexible material to match the brain-computer interface device with biological tissue. A vital sign detection element is further provided, and the vital sign signals and EEG signals can be collected through the same interface to achieve real-time monitoring of the vital sign signals. The detection electrodes, signal transmission components, metal wiring, and vital sign detection elements are integrated into one, and are cast using liquid metal. The processing is simple and convenient, and it has broad application prospects.

[0088] It should be noted that the manufacturing method of the integrated brain-computer interface device described in this embodiment has the same technical effect as the integrated brain-computer interface device described in the previous embodiment, and this embodiment will not be repeated here.

[0089] This application does not need to be executed in the above order. As long as it does not violate the logic, the execution order of the steps can be changed. For example, step S30 can occur before step S10.

[0090] Another embodiment of the present application provides a method for using the integrated brain-computer interface device described in the aforementioned embodiment, such as Figure 6 As shown, the contact electrode is fixed to the mouse brain; the signal transmission component is connected to the analyzer to achieve plug-and-play between the brain-computer interface device and the analyzer; at the same time, the brain-computer interface device is integrated with a vital sign detection element, so that the EEG signal and the sensor signal can be synchronously collected through the same interface, thereby realizing real-time monitoring, comparison and analysis of the movement, temperature or pressure signals of the organism and the EEG signals.

[0091] Obviously, the above embodiments of the present application are merely examples for clearly illustrating the present application, and are not intended to limit the implementation methods of the present application. For ordinary technicians in the relevant field, other different forms of changes or modifications can be made based on the above description. It is impossible to list all implementation methods here. All obvious changes or modifications derived from the technical solution of the present application are still within the scope of protection of the present application.

Claims

1. An integrated brain-computer interface device, characterized in that: include: A first flexible substrate and a second flexible substrate bonded thereto, wherein: A groove structure filled with liquid metal and a vital sign detection element are formed on a surface of the first flexible substrate opposite to the second flexible substrate, wherein the groove structure filled with liquid metal constitutes a transfer electrode in the interface transfer area, a wiring in the wiring area, and a detection electrode in the electroencephalogram signal detection electrode area, and the vital sign detection element is connected to the wiring in the wiring area to achieve transmission of vital sign signals detected by the vital sign detection element; The second flexible substrate is provided with: an opening penetrating the second flexible substrate, the opening being aligned with the detection electrode, and a contact electrode in contact with the detection electrode being formed in the opening; The signal transmission component transmits the brain electrical signal detected by the contact electrode and the vital sign signal to the analyzer for analysis via the corresponding wiring in the wiring area and the corresponding adapter electrodes in the interface adapter area.

2. The device according to claim 1, characterized in that The signal transmission component is a flexible tubular structure filled with the liquid metal, a first port of which is connected to the first flexible substrate and the groove structure filled with the liquid metal, and a second port of which is connected to the analyzer.

3. The brain-computer interface device according to claim 2, characterized in that: The shape of the second port is configured to be compatible with the signal input port of the analyzer.

4. The brain-computer interface device according to claim 1, wherein: The liquid metal includes at least one of single-substance metal gallium, gallium-based alloy and bismuth-based alloy, or a combination of several of them.

5. The brain-computer interface device according to claim 1, characterized in that The contact electrode is an inert electrode.

6. The brain-computer interface device according to claim 1, characterized in that The device further includes a vital sign detection element accommodating groove formed on a surface of the first flexible substrate opposite to the second flexible substrate, and the vital sign detection element is disposed in the accommodating groove.

7. The brain-computer interface device according to claim 6, characterized in that: The vital sign detection element is a physiological saline and silicone oil solution filled in the receiving groove, and the silicone oil is suspended in the physiological saline; The vital sign detection element and a portion of the corresponding wiring form a capacitor, thereby constituting a motion sensor.

8. The brain-computer interface device according to claim 6, characterized in that: The vital sign detection element is a body temperature sensor or a blood oxygen sensor arranged in the accommodating groove.

9. The brain-computer interface device according to claim 1, characterized in that: The first flexible substrate and the second flexible substrate are made of flexible materials to achieve compatibility between the brain-computer interface device and biological tissue.

10. The brain-computer interface device according to claim 9, characterized in that: The flexible materials include polymers, silicone rubber and polydimethylsiloxane.

11. A method for manufacturing an integrated brain-computer interface device according to any one of claims 1 to 10, characterized in that: include: forming a first flexible substrate, wherein a groove structure and a vital sign detection element are formed on a first surface of the first flexible substrate, wherein the groove structure includes an interface adapter area, a wiring area, and an electroencephalogram signal detection electrode area; Laying the second flexible substrate onto the first flexible substrate facing the first surface; forming a flexible tubular connector; Connecting the first end of the flexible tubular connector to the first flexible substrate and the groove structure to be filled with liquid metal; Liquid metal is poured through the second end of the flexible tubular connector so that the groove structure is filled with liquid metal, thereby forming a transfer electrode in the interface transfer area, a wiring in the wiring area, and a detection electrode in the EEG signal detection electrode area, and the tubular connector is filled with liquid metal to form a signal transmission component, so as to transmit the EEG signal detected by the detection electrode and the vital sign signal detected by the vital sign detection element to the analyzer for analysis via the corresponding wiring in the wiring area, the corresponding transfer electrode in the interface transfer area, and the second end respectively; An opening is formed through the second flexible substrate, the opening is aligned with the detection electrode, and a contact electrode in contact with the detection electrode is formed in the opening.

12. The manufacturing method according to claim 11, characterized in that: The first flexible substrate is formed, wherein a groove structure and a vital sign detection element are formed on a first surface of the first flexible substrate, wherein the groove structure includes an interface transfer area, a wiring area, and an electroencephalogram signal detection electrode area, including: Pour silicone into a first mold having a convex structure opposite to the groove structure to be formed, heat the first mold to solidify the silicone in the groove of the first mold, remove the silicone from the groove after solidification, and form an opening corresponding to the interface transition area.

13. The manufacturing method according to claim 11, characterized in that: The forming of the flexible tubular connector comprises: Providing a second mold, wherein the second mold is a cavity structure including a first end plate and a second end plate, wherein the first end plate has a first opening corresponding to the transfer electrode to be formed, and the second end plate has a second opening corresponding to the signal input port of the analyzer; placing a support core in the cavity, wherein one end of the support core extends to the first opening and the other end extends to the second opening; The second mold is poured with silica gel from the first opening or the second opening, the second mold is heated to solidify the silica gel in the second mold, and the support core is removed from the silica gel after the silica gel is solidified.

14. A method for using the integrated brain-computer interface device according to any one of claims 1-10, characterized in that: include: fixing the contact electrode to the brain; Connect the signal transmission component to the analyzer.

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