A pre-treatment device for testing samples

Abstract

The present invention discloses a pre-processing device for detecting samples, which comprises: a sample loading component, a manipulator, a screw cap component, a feeding component, an oscillation component, a centrifugal component and a transfer component; the sample loading component has a storage rack and a lifting drive component, the storage rack defines a plurality of accommodating cavities, and test tubes are stacked in each accommodating cavity; the manipulator is provided with an adsorption component for simultaneously adsorbing a plurality of test tubes and transferring the test tubes between the sample loading component, the plurality of transfer components, the oscillation component and the centrifugal component; the screw cap component has a second clamping component and a screw cap drive component; the feeding component is suitable for adding liquid or salt into the test tube with the cover screwed off; the oscillation component has a test tube rack and a first lifting drive component; the centrifugal component has a centrifugal disk, a plurality of rotating plates and a rotating drive component; when the centrifugal disk rotates, the rotating plates rotate to switch the placed tubes from an upright state to a horizontal state, so that the pre-processing device can improve the processing efficiency of the sample and improve the centrifugal effect.

Description

Technical Field

[0001] The present invention relates to the technical field of sample detection, and in particular to a pre-processing device for detecting samples. Background Art

[0002] Before testing samples, it is often necessary to add salt, reagents, shake, centrifuge, etc. to the samples.

[0003] The automation device in the related art can perform automated pre-processing operations on the test samples, but its efficiency is low and the centrifugal effect on the samples is limited. Summary of the Invention

[0004] The present invention aims to solve at least one of the technical problems in the above-mentioned technology to a certain extent. To this end, the present invention aims to provide a pre-treatment device for detecting samples, thereby improving the sample processing efficiency and the centrifugal effect.

[0005] To achieve the above-mentioned object, an embodiment of the present invention provides a pre-processing device for testing samples, wherein the test sample is placed in a test tube, and the test tube is covered with a cover. The pre-processing device includes: a sample loading component, a manipulator, a capping component, a feeding component, an oscillating component, a centrifugal component, and a plurality of transfer components;

[0006] The sample loading assembly comprises a storage rack and a lifting drive member, wherein the storage rack defines a plurality of accommodating cavities, each of which is open at the top and provided with a through hole at the bottom, wherein a plurality of test tubes are stacked in each of the accommodating cavities, and the lifting drive member comprises a plurality of lift bars, each of which is adapted to be inserted into each of the through holes and lift the test tubes in each of the accommodating cavities to the top of the accommodating cavities;

[0007] Several transfer assemblies are arranged side by side, and the transfer assemblies are arranged below the screw cap assembly and the feeding assembly. Each transfer assembly includes a first clamping member and a first moving drive member. The first clamping member is provided with a plurality of first clamping openings for simultaneously clamping the tube bodies of a plurality of test tubes. The first moving drive member is connected to the first clamping member to drive the first clamping member to move the test tubes.

[0008] The manipulator is provided with a plurality of adsorption components for simultaneously adsorbing a plurality of test tubes and transferring the test tubes between the loading component, the plurality of transfer components, the shaking component and the centrifugal component;

[0009] The capping assembly comprises a second clamping member and a capping driving member, wherein the second clamping member is provided with a plurality of second clamping openings for simultaneously clamping the caps of a plurality of test tubes, and the capping driving member is connected to the second clamping member to drive the second clamping member to drive the cap to unscrew or screw on the tube body;

[0010] The feeding assembly is suitable for adding liquid or salt into the test tube with the lid unscrewed;

[0011] The oscillating assembly comprises a test tube rack and a first lifting drive member, wherein the test tube rack is provided with a plurality of test tube storage slots, and the first lifting drive member is adapted to drive the test tube rack to move upward and downward;

[0012] The centrifugal assembly comprises a centrifugal disc, a plurality of rotating plates and a rotary drive member; the centrifugal disc is circumferentially provided with a plurality of mounting grooves; the plurality of rotating plates are arranged in a one-to-one correspondence within the plurality of mounting grooves and each of the rotating plates is rotatable within each of the mounting grooves with a rotating shaft as a fulcrum, and at least one placement tube for placing a test tube is provided on the rotating plate; the rotary drive member is connected to the centrifugal disc to drive the centrifugal disc to rotate, and when the centrifugal disc rotates, each of the rotating plates rotates to switch the placement tube from an upright state to a horizontal state.

[0013] According to a pre-treatment device for detecting samples proposed by the present invention, in a sample loading component, multiple test tubes of samples to be detected can be lifted to the top of the accommodating chamber at the same time, and the adsorption parts on the manipulator simultaneously adsorb and transfer them to the transfer component. The transfer component simultaneously transfers the multiple test tubes to the screw cap component for simultaneous opening of multiple covers, and then the feeding component simultaneously adds liquid or salt to the multiple test tubes. After the addition is completed, the screw cap component screws on the cover, and then the adsorption parts on the manipulator simultaneously adsorb and transfer them to the shaking component. The shaking component simultaneously shakes the multiple test tubes. After the shaking is completed, the test tubes are simultaneously adsorbed and transferred to the centrifugal component by the adsorption parts on the manipulator. When the centrifugal disk of the centrifugal component rotates, under the action of centrifugal force, the placement tubes can be changed from an upright state to a horizontal state, so that the centrifugal effect of the liquid in the test tube is better. Therefore, multiple test tubes can be loaded, added, screwed on, shaken, centrifuged, etc. at the same time, greatly improving the sample processing efficiency. In addition, the provision of multiple transfer components can synchronize the steps of transferring, screwing on, adding liquid, adding salt, etc. of the test tubes.

[0014] This equipment is a fully automatic pre-testing platform that can perform sample pre-treatment and sample testing in batches, and realize standard and standardized operations in the pre-testing process (after sampling) of pesticide residues in plant-derived foods, medicines, and medicinal materials. It can be applied to the pre-treatment of pesticide residue detection standards such as "GB 23200.121-2021 National Food Safety Standard Determination of 331 Pesticides and Their Metabolite Residues in Plant-Derived Foods by Liquid Chromatography-Mass Spectrometry" and "GB 23200.113-2018 National Food Safety Standard Determination of 208 Pesticides and Their Metabolite Residues in Plant-Derived Foods by Liquid Chromatography-Mass Spectrometry". The equipment automatically completes the pre-testing process instead of manual operation by the experimenter; it realizes stable reproducibility of the sample pre-treatment process, effectively improves the efficiency of pre-testing, and effectively improves the stability of the test results.

[0015] In addition, the sample pre-processing device proposed in the present invention may also have the following additional technical features:

[0016] Optionally, a plurality of accommodating cavity arrays are arranged on the storage rack.

[0017] Optionally, the first clamping opening of the first clamping member is constructed by an air clamp.

[0018] Optionally, the second clamping member has a plurality of first clamping fingers, a plurality of second clamping fingers, a second movable driving member and a second lifting driving member, and the plurality of first clamping fingers and the plurality of second clamping fingers correspond one to one to jointly construct a plurality of second clamping openings, the plurality of first clamping fingers are connected to the rotating driving member, the plurality of second clamping fingers are connected to the movable end of the second lifting driving member, and the second lifting driving member is arranged on the movable end of the second movable driving member.

[0019] Furthermore, the rotary cover assembly further includes a third lifting drive member and a support plate, the rotary cover drive member is arranged on the support plate, and the third lifting drive member is connected to the support plate to drive the second clamping member to move up and down to contact the cover body.

[0020] Optionally, there are multiple screw cap assemblies and multiple feeding assemblies, and the multiple screw cap assemblies are arranged in a one-to-one correspondence with the multiple feeding assemblies.

[0021] Optionally, the oscillation assembly includes a limiting portion and a first moving pair; the limiting portion includes a limiting plate and a third moving drive member, the limiting plate is suitable for abutting against the cover of the test tube of the test tube rack, and the third moving drive member is arranged on the test tube rack and connected to the limiting plate to drive the limiting plate to move to abut or leave the cover; the first moving pair is arranged upright, and the slider of the first moving pair is connected to the test tube rack and the first lifting drive member.

[0022] Furthermore, the first lifting drive component includes a motor, a first connecting rod and a second connecting rod, one end of the first connecting rod is connected to one end of the second connecting rod, the other end of the first connecting rod is connected to the power output shaft of the motor, and the other end of the second connecting rod is connected to the slider.

[0023] Optionally, a sampling component is further included, which has a tip rack, a pipette and a fourth movable drive component. A plurality of tips are arranged in an array on the tip rack. The pipette is arranged above the tip rack and connected to the fourth movable drive component. The fourth movable drive component drives the pipette to move between one of the transfer components and the tip rack so that the pipette can aspirate liquid or replace the tip.

[0024] Furthermore, a collecting bucket suitable for collecting waste liquid is provided on the side of the tip rack, and the pipette gun moves between one of the transfer components, the tip rack and the collecting bucket. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 2 is a schematic structural diagram of a sample pre-processing device according to an embodiment of the present invention;

[0026] Figure 2 is a structural schematic diagram of another perspective of a pre-treatment device for detecting samples according to an embodiment of the present invention;

[0027] Figure 3 Schematic diagram of the structure of a sample loading component according to an embodiment of the present invention;

[0028] Figure 4 is a structural schematic diagram of a sample loading assembly according to an embodiment of the present invention from another perspective;

[0029] Figure 5 A schematic structural diagram of a manipulator according to an embodiment of the present invention;

[0030] Figure 6 is a structural schematic diagram of a transfer assembly according to an embodiment of the present invention;

[0031] Figure 7 is a structural schematic diagram of a rotary cover assembly according to an embodiment of the present invention;

[0032] Figure 8 is a structural schematic diagram of a rotary cover assembly from another perspective according to an embodiment of the present invention;

[0033] Figure 9 is a schematic structural diagram of an oscillating assembly according to an embodiment of the present invention;

[0034] Figure 10 A schematic structural diagram of a centrifugal assembly according to an embodiment of the present invention;

[0035] Figure 11 is a structural schematic diagram of some components of a centrifugal assembly according to an embodiment of the present invention;

[0036] Figure 12 A schematic structural diagram of a housing of a centrifugal assembly according to an embodiment of the present invention;

[0037] Figure 13 for Figure 2 A partial enlarged view of

[0038] Description of reference numerals:

[0039] Sample loading assembly 10, storage rack 101, accommodating cavity 1011, through hole 1012, long slot 1013, induction switch 1014, lifting drive member 102, and lifting bar 1021;

[0040] Transfer assembly 20, first clamping member 201, first clamping port 2011, first moving driving member 202, first motor 2021, slider guide assembly 2022, first belt 2023, first driving wheel 2024, first driven wheel 2025;

[0041] Manipulator 30, suction element 301;

[0042] The capping assembly 40, the second clamping member 401, the second clamping opening 4011, the first clamping finger 4012, the second clamping finger 4013, the second moving driver 4014, the second lifting driver 4015, the capping driver 402, the third lifting driver 403, and the support plate 404;

[0043] Feeding assembly 50;

[0044] Oscillating assembly 60, test tube rack 601, test tube storage slot 6011, first lifting drive 602, second connecting rod 6021, first connecting rod 6022, second motor 6023, limiting portion 603, limiting plate 6031, third movable drive 6032, first movable pair 604;

[0045] Centrifugal assembly 70, centrifugal disc 701, mounting groove 7011, U-shaped groove 7012, rotating plate 702, rotating shaft 7021, rotary drive member 703, support rod 7031, second belt 7032, second driving pulley 7033, second driven pulley 7034, third motor 7035, placement tube 704, housing 705;

[0046] Sampling assembly 80 , tip rack 801 , tip 8011 , pipette gun 802 , fourth movable driving member 803 , and collection bucket 804 . DETAILED DESCRIPTION

[0047] The following describes embodiments of the present invention in detail, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, and are not to be construed as limiting the present invention.

[0048] To better understand the above technical solutions, exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. Although exemplary embodiments of the present invention are shown in the accompanying drawings, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments described herein. Instead, these embodiments are provided to enable a more thorough understanding of the present invention and to fully convey the scope of the present invention to those skilled in the art.

[0049] In order to better understand the above technical solution, the above technical solution will be described in detail below with reference to the accompanying drawings and specific implementation methods.

[0050] Reference below Figure 1 and Figure 2 , describing a pretreatment device for detecting samples proposed according to an embodiment of the present invention, wherein the detection sample is placed in a test tube, and a cover body is provided on the test tube. The pretreatment device includes: a sample loading component 10, a plurality of transfer components 20, a manipulator 30, a screw cap component 40, a feeding component 50, an oscillation component 60 and a centrifugal component 70.

[0051] Specifically, the loading component 10 has a storage rack 101 and a lifting drive 102. The storage rack 101 defines a plurality of accommodating cavities 1011. The top of each accommodating cavity 1011 is open and the bottom is provided with a through hole 1012. A plurality of test tubes are stacked in each accommodating cavity 1011. The lifting drive 102 has a plurality of top bars 1021. Each top bar 1021 is suitable for inserting into each through hole 1012 and lifting the test tube in each accommodating cavity 1011 to the top of the accommodating cavity 1011. It can be understood that the loading component 10 drives the plurality of top bars 1021 to insert into the plurality of through holes 1012 and lift the plurality of test tubes to the top of the accommodating cavity 1011 through the lifting drive 102, so as to facilitate the robot 30 to take the material, thereby simultaneously loading multiple test tubes.

[0052] Several transfer assemblies 20 are arranged side by side, and transfer assemblies 20 are arranged below the capping assembly 40 and the feeding assembly 50. Each transfer assembly 20 includes a first clamping member 201 and a first movable driving member 202. The first clamping member 201 is provided with several first clamping ports 2011 to clamp the tube bodies of several test tubes at the same time. The first movable driving member 202 is connected to the first clamping member 201 to drive the first clamping member 201 to move the test tube; it can be understood that the transfer assembly 20 is used to carry the test tube in each workstation and transfer the test tube to the workstation to be processed, such as capping and feeding.

[0053] The manipulator 30 is provided with a plurality of adsorption parts 301 to simultaneously adsorb a plurality of test tubes and transfer the test tubes between the loading assembly 10, a plurality of transfer assemblies 20, an oscillation assembly 60 and a centrifuge assembly 70; it can be understood that the manipulator 30 and the transfer assembly 20 cooperate to transfer the test tubes between the various processing stations, and the manipulator 30 is also provided with multiple adsorption parts 301, which can transfer multiple test tubes at the same time.

[0054] The screw cap assembly 40 has a second clamping member 401 and a screw cap driving member 402. The second clamping member 401 is provided with a plurality of second clamping openings 4011 for simultaneously clamping the caps of a plurality of test tubes. The screw cap driving member 402 is connected to the second clamping member 401 to drive the second clamping member 401 to drive the cap to unscrew or screw on the tube body. In particular, multiple screw cap assemblies 40 can also be arranged.

[0055] The feeding assembly 50 is suitable for adding liquid or salt into the test tube with the cover unscrewed; the oscillation assembly 60 has a test tube rack 601 and a first lifting drive member 602. The test tube rack 601 is provided with a plurality of test tube storage slots 6011. The first lifting drive member 602 is suitable for driving the test tube rack 601 to move up and down.

[0056] The centrifuge assembly 70 comprises a centrifugal disc 701, a plurality of rotating plates 702, and a rotary drive member 703. The centrifugal disc 701 is circumferentially provided with a plurality of mounting slots 7011. The plurality of rotating plates 702 are disposed in a corresponding manner within the mounting slots 7011, and each rotating plate 702 is rotatable within each mounting slot 7011 with a rotating shaft 7021 serving as a fulcrum. The rotating plates 702 are provided with at least one placement tube 704 for placing a test tube. The rotary drive member 703 is connected to the centrifugal disc 701 to drive the centrifugal disc 701 to rotate. When the centrifugal disc 701 rotates, the rotating plates 702 rotate, causing the placement tube 704 to switch from an upright position to a horizontal position. In other words, when the centrifugal disc 701 rotates, the rotating plates 702 rotate, causing the placement tube 704 to switch from an upright position to a horizontal position under the action of centrifugal force, thereby improving the centrifugation effect of the test tube solution in the placement tube.

[0057] Therefore, according to a pre-treatment device for detecting samples according to an embodiment of the present invention, in the sample loading component 10, the stackable test tubes of the sample loading component 10 and the lifting drive component 102 can lift the test tubes to the top of the accommodating chamber 1011 for easy grasping by the manipulator 30, thereby simultaneously lifting multiple test tubes of samples to be detected to the top of the accommodating chamber 1011, and the adsorption component 301 on the manipulator 30 simultaneously adsorbs and transfers them to the transfer component 20; the transfer component 20 simultaneously transfers the multiple test tubes to the screw cap component 40 to perform the simultaneous opening operation of multiple covers, and then the feeding component 50 adds liquid or salt to the multiple test tubes at the same time, and adds After the material is completed, the cover is screwed on by the screw cap assembly 40, and then the adsorption part 301 on the manipulator 30 simultaneously adsorbs and transfers it to the shaking assembly 60. The shaking assembly 60 performs shaking operations on multiple test tubes at the same time. After the shaking is completed, the test tubes are simultaneously adsorbed and transferred to the centrifugal assembly 70 by the adsorption part 301 on the manipulator 30. When the centrifugal disk 701 of the centrifugal assembly 70 rotates, under the action of centrifugal force, the placement tube 704 can be changed from an upright state to a horizontal state, so that the liquid in the test tube has a better centrifugal effect. In this way, multiple test tubes can be loaded with samples, added materials, screwed on, shaken, centrifuged and other operations at the same time, greatly improving the sample processing efficiency.

[0058] Combine Figure 3 and Figure 4 , for the sample loading component 10, the sample loading component 10 has a storage rack 101 and a lifting drive 102, the storage rack 101 defines a plurality of accommodating chambers 1011, the top of each accommodating chamber 1011 is open and the bottom is provided with a through hole 1012, and a plurality of test tubes are stacked in each accommodating chamber 1011, and the lifting drive 102 has a plurality of top bars 1021, each top bar 1021 is suitable for inserting into each through hole 1012 and lifting the test tube in each accommodating chamber 1011 to the top of the accommodating chamber 1011; wherein the plurality of accommodating chambers 1011 are arranged in an array on the storage rack 101, and the size of the accommodating chamber 1011 can be of two specifications as shown in the figure, and the number of holes in the accommodating chamber 1011 of one specification can be as follows Figure 3 The specific number can be designed based on actual needs. Since multiple test tubes can be stacked vertically in each accommodating cavity 1011, the device can save space. Test tubes are placed in the accommodating cavities 1011, and the lifting bars 1021 are adapted to be inserted into the through holes 1012 and lift the test tubes in each accommodating cavity 1011 to the top of the accommodating cavity 1011. Each accommodating cavity 1011 is provided with a long groove 1013 on the side, through which the interior is visible. A sensor switch 1014 is provided at the end of the long groove 1013 to detect whether the test tube has been lifted to the top of the accommodating cavity 1011, facilitating grasping by the robot arm 30.

[0059] The lifting drive member 102 may be a motor screw structure, wherein several lifting bars 1021 are connected together and then connected to the motor screw structure through a central rod. The motor screw structure drives the several lifting bars 1021 to move up and down simultaneously.

[0060] Combine Figure 5 , as for the transfer assembly 20, several transfer assemblies 20 are arranged side by side, and transfer assemblies 20 are arranged below the screw cap assembly 40 and the feeding assembly 50. Each transfer assembly 20 includes a first clamping member 201 and a first movable driving member 202. The first clamping member 201 is provided with several first clamping ports 2011 to clamp the tube bodies of several test tubes at the same time. The first movable driving member 202 is connected to the first clamping member 201 to drive the first clamping member 201 to drive the test tube to move; wherein, several transfer assemblies 20 are arranged side by side, and the number of the transfer assemblies 20 can be set corresponding to the number of the screw cap assembly 40 and the feeding assembly 50, which helps to improve production efficiency. The number of the transfer assemblies 20 can be four groups as shown in the figure, and the specific number can be designed according to actual application.

[0061] In addition, the first clamping opening 2011 of the first clamping member 201 may be as follows Figure 5 The air clamp structure can have three fingers 2012 as shown in the figure. The contact surface between each finger 2012 and the test tube can be set into a V shape to facilitate clamping of the cylindrical test tube. The first mobile drive member 202 can include a first motor 2021, a slider guide assembly 2022, a first belt 2023, a first driving wheel 2024, and a first driven wheel 2025. The first motor 2021 drives the first driving wheel 2024 to rotate the first belt 2023 and the first driven wheel 2025, so that the first clamping member 201 moves on the slider guide assembly 2022. The transfer assembly 20 cooperates with the screw cap assembly 40 to facilitate the subsequent addition of salt and liquid to the sample to be tested in the test tube.

[0062] Combine Figure 6 The robot 30 is equipped with a plurality of suction members 301 for simultaneously sucking multiple test tubes and transferring them between the sample loading assembly 10, the plurality of transfer assemblies 20, the vibration assembly 60, and the centrifuge assembly 70. The number of suction members 301 can be four, as shown in the figure. The specific number can be designed based on actual application. The simultaneous suction of multiple suction members 301 to transfer multiple test tubes between various workstations can reduce the number of transfer operations and thus improve production efficiency. The suction members 301 can be vacuum cup structures.

[0063] Combine Figure 7 and Figure 8 As for the screw cap assembly 40, the screw cap assembly 40 has a second clamping member 401 and a screw cap driving member 402. The second clamping member 401 is provided with a plurality of second clamping openings 4011 to clamp the caps of a plurality of test tubes at the same time. The screw cap driving member 402 is connected to the second clamping member 401 to drive the second clamping member 401 to drive the cap to unscrew or screw on the tube body; the number of the second clamping members 401 can be four as shown in the figure, and the specific number can be designed according to actual application.

[0064] Specifically, the second clamping member 401 has several first clamping fingers 4012, several second clamping fingers 4013, a second movable driving member 4014 and a second lifting driving member 4015. The first clamping fingers 4012 can be two as shown in the figure, and the number of second clamping fingers 4013 can be one as shown in the figure. Several first clamping fingers 4012 and several second clamping fingers 4013 correspond to each other to jointly construct several second clamping openings 4011. Several first clamping fingers 4012 are connected to the screw cap driving member 402, and several second clamping fingers 4013 are connected to the moving end of the second lifting driving member 4015. The second lifting driving member 4015 is arranged on the moving end of the second movable driving member 4014; the cover body can be firmly clamped by the cooperation of the first clamping fingers 4012 and the second clamping fingers 4013, and the screw cap driving member 402 simultaneously drives multiple groups of second clamping members 401, thereby realizing that the covers of several test tubes are unscrewed or screwed on at the same time, thereby improving production efficiency. The cap screwing drive 402 may be a structure composed of a motor, a synchronous belt, and gears. Each first clamping finger 4012 is connected to a gear, and the gears are connected to the motor via a synchronous belt transmission. The second movable drive 4014 may be a cylinder structure. The second movable drive 4014 is adapted to drive the second clamping finger 4013 to move and cooperate with the first clamping finger 4012 to clamp the cap. The second lifting drive 4015 causes the rod connected to the second clamping finger 4013 to separate from the second clamping finger 4013, so that the cap screwing drive 402 can synchronously drive the second clamping member 401 to rotate the cap to open or close the cap.

[0065] Furthermore, the cover rotating assembly 40 further includes a third lifting drive member 403 and a support plate 404. The cover rotating drive member 402 is disposed on the support plate 404. The third lifting drive member 403 is connected to the support plate 404 to drive the second clamping member 401 to move upward and downward to contact the cover body. The third lifting drive member 403 can be a cylinder structure.

[0066] like Figure 13 As shown, the feeding component 50 is suitable for adding liquid or salt into the test tube with the cover unscrewed; the feeding component 50 can be provided with two funnels as shown in the figure, and the specific number can be designed according to actual application. The funnel is connected to the drainage tube through a tube to add liquid or salt into the unscrewed test tube to facilitate the reaction of the solution.

[0067] Combine Figure 9, as for the oscillation component 60, the oscillation component 60 has a test tube rack 601 and a first lifting drive member 602, the test tube rack 601 is provided with a plurality of test tube storage slots 6011, and the first lifting drive member 602 is suitable for driving the test tube rack 601 to move up and down; the oscillation component 60 also includes a limiting portion 603 and a first moving pair 604; the limiting portion 603 includes a limiting plate 6031 and a third moving drive member 6032, the limiting plate 6031 is suitable for abutting against the cover of the test tube of the test tube rack 601, the third moving drive member 6032 is arranged on the test tube rack 601 and connected to the limiting plate 6031 to drive the limiting plate 6031 to move and abut or leave the cover; the first moving pair 604 is arranged upright, and the slider of the first moving pair 604 connects the test tube rack 601 and the first lifting drive member 602. The test tube rack 601 is provided with a plurality of test tube storage slots 6011 for storing test tubes; the limiting portion 603 comprises a limiting plate 6031 and a third movable driving member 6032, and the limiting plate 6031 is driven by the third movable driving member to abut or leave the cover so that the test tube can be restricted on the test tube rack 601 after being placed; the test tube rack 601 and the first lifting driving member 602 are connected by a slider of the first movable pair 604, and the first lifting driving member 602 is suitable for driving the slider to drive the test tube rack 601 to move up and down, thereby fixing a plurality of test tubes of different specifications on the test tube rack 601 at the same time and moving them back and forth To realize the oscillation function of the reagents in the test tube, the oscillation component 60 has the function of accommodating test tubes of various specifications, has a compact structure and occupies a small space; thus, the limit plate 6031 on the limit part 603 abuts against the cover of the test tube to prevent the test tube from being shaken out during oscillation, and also enables test tubes of any size to be placed on the test tube storage slot, and the first lifting drive member 602 drives the first moving pair 604 to drive the test tube rack 601 to move up and down to perform the oscillation operation, wherein the first moving pair 604 is arranged upright, so that the various components are arranged in the vertical space, which can reduce the space occupied by the entire oscillation device.

[0068] Specifically, if Figure 9 As shown, for the test tube rack 601, the test tube rack 601 is provided with several test tube storage slots 6011, which can hold several test tubes of different specifications. The number of the test tube storage slots 6011 can be eight as shown in the figure, and the specifications can be two as shown in the figure (for placing 50mL test tubes and 15mL test tubes). The specific specifications and quantity can be designed according to needs.

[0069] For the limiting part 603, the limiting part 603 has a limiting plate 6031 and a third movable driving member 6032. The limiting plate 6031 is suitable for abutting against the cover of the test tube of the test tube rack 601; the limiting plate 6031 includes a vertical plate and a horizontal frame. One end of the vertical plate is connected to the third movable driving member 6032, and the other end is connected to the horizontal frame. The horizontal frame is suitable for abutting against the cover of the test tube of the test tube rack 601. The horizontal frame can be two horizontal bars as shown in the figure. The outer horizontal bar is used to fix the outer row of test tubes, and the inner horizontal bar is used to fix the inner row of test tubes. The specific number of horizontal bars can be set accordingly according to the number of test tubes on the test tube rack 601.

[0070] The third movable driver 6032 is disposed on the test tube rack 601 and connected to the limiting plate 6031 to drive the limiting plate 6031 to move toward or away from the cover. The third movable driver 6032 includes a horizontal movable driver and a Z-axis movable driver. The limiting plate 6031 is disposed on the movable end of the horizontal movable driver, and the horizontal movable driver is disposed on the movable end of the Z-axis movable driver. The horizontal movable driver can be a cylinder, as shown in the figure, to drive the limiting plate 6031 in the horizontal direction. The Z-axis movable driver can be a cylinder, as shown in the figure, to drive the limiting plate in the Z-axis direction.

[0071] That is to say, several test tubes placed on the test tube rack 601 are prone to fall during the oscillating movement. The limit plate 6031 is driven to the first position (limit plate avoidance position) by the horizontal moving drive component, and several test tubes are placed on the test tube rack 601. The limit plate 6031 is driven to the second position (the upper position where the limit plate 6031 is to be abutted against the cover body) by the horizontal moving drive component, and then the horizontal frame is driven to abut against the cover body by the Z-axis moving drive component, so that test tubes of different specifications can be restricted on the test tube rack 601 at the same time.

[0072] like Figure 9 As shown, for the first movable pair 604, the first movable pair 604 is arranged upright, and the slider of the first movable pair 604 connects the test tube rack 601 and the first lifting drive member 602, wherein the first movable pair 604 can be a linear slide rail and a slider as shown in the figure, through the connection between the first movable pair 604 and the test tube rack 601, and under the drive of the first lifting drive member 602, the first lifting drive member 602 drives the test tube rack 601 to achieve lifting movement.

[0073] The first lifting drive member 602 is suitable for driving the slider to drive the test tube rack 601 to move up and down; the first lifting drive member 602 includes a second motor 6023, a first connecting rod 6022 and a second connecting rod 6021, one end of the first connecting rod 6022 is connected to one end of the second connecting rod 6021, the other end of the first connecting rod 6022 is connected to the power output shaft of the motor, and the other end of the second connecting rod 6021 is connected to the slider; wherein one end of the second connecting rod 6021 can be as follows Figure 9The second connecting rod 6021 is connected to the first connecting rod 6022 through two bearings; the other end of the second connecting rod 6021 can be connected to the slider through two bearings as shown in the figure; the second motor 6023 is connected to the first connecting rod 6022, the second connecting rod 6021 and the slider so that the motor drives the test tube rack 601 on the slider to achieve lifting movement.

[0074] Combine Figure 10-12 As for the centrifugal assembly 70, the centrifugal assembly 70 includes a centrifugal disk 701, a plurality of rotating plates 702, and a rotating drive member 703; the centrifugal disk 701 is circumferentially distributed with a plurality of mounting grooves 7011; the plurality of rotating plates 702 are correspondingly arranged in the plurality of mounting grooves 7011 and each rotating plate 702 is rotatable in each mounting groove 7011 with a rotating shaft 7021 as a fulcrum, and at least one placement tube 704 for placing a test tube is provided on the rotating plate 702; the rotating drive member 703 is connected to the centrifugal disk 701 to drive the centrifugal disk 701 to rotate. When the centrifugal disk 701 rotates, each rotating plate 702 rotates to switch the placement tube 704 from an upright state to a horizontal state. Among them, the centrifugal disk 701 has several mounting grooves 7011 distributed circumferentially. Under the drive of the rotating drive member 703, the mounting grooves 7011 on the centrifugal disk 701 are driven to drive the placement tube 704 to rotate. Since the several rotating plates 702 are arranged in the several mounting grooves 7011 one by one and each rotating plate 702 can rotate in each mounting groove 7011 with the rotating shaft 7021 as the fulcrum, when the centrifugal disk 701 rotates, each rotating plate 702 rotates to switch the placement tube 704 from a vertical state to a horizontal state, so that the test tube solution in the placement tube 704 has a better separation effect.

[0075] like Figure 10 As shown, for the centrifugal disc 701, the centrifugal disc 701 has a plurality of mounting grooves 7011 distributed circumferentially. The circumferential distribution of the centrifugal disc 701 can be as follows: Figure 10 The side arms of two adjacent Y-shaped rods are parallel to each other and jointly form a mounting groove 7011; a U-shaped groove 7012 is provided on the side arm of the mounting groove 7011, and a rotating shaft 7021 is rotatably disposed in the U-shaped groove 7012; the U-shaped groove 7012 is tilted downward from the side close to the center of the centrifugal disk 701 to the side away from the center of the centrifugal disk 701, and the rotating shafts 7021 at both ends of the rotating plate 702 can be arranged in the U-shaped groove 7012 with a clearance fit. The tilted downward setting facilitates the installation of the rotating plate 702 and facilitates the rotation of the rotating plate 702 during centrifugal action.

[0076] As for the rotating plate 702, a plurality of rotating plates 702 are arranged in a plurality of mounting grooves 7011 in a one-to-one correspondence, and each rotating plate 702 can rotate in each mounting groove 7011 with a rotating shaft 7021 as a fulcrum. At least one placement tube 704 for placing a test tube is provided on the rotating plate 702. When the rotating plate 702 rotates, the placement tube 704 switches from a vertical state to a horizontal state. The number of placement tubes 704 on the rotating plate can be as follows: Figure 1 Two of the two placement tubes 704 are arranged on both sides of the rotating shaft 7021, and the number of the placement tubes 704 can be designed according to needs; the rotating plate 702 can rotate in the installation groove 7011 with the rotating shaft 7021 as the fulcrum. When the centrifuge rotates, the rotating plate 702 rotates to switch the placement tube 704 from a vertical state to a horizontal state, so that the test tube solution in the placement tube 704 is more effectively separated.

[0077] As for the rotary driving member 703, the rotary driving member 703 is connected to the centrifugal disk 701 to drive the centrifugal disk 701 to rotate. The rotary driving member 703 can be composed of a support rod 7031, a second belt 7032, a second driving pulley 7033, a second driven pulley 7034 and a third motor 7035 as shown in the figure; one end of the support rod 7031 is connected to the centrifugal disk 701, and the other end is connected to the second driven pulley 7034, the second driving pulley 7033 is connected to the third motor 7035, and the second belt 7032 is driven to connect the second driving pulley 7033 and the second driven pulley 7034; that is, the centrifugal disk 701 connected to the support rod 7031 is driven by the third motor 7035, and the centrifugal disk 701 rotates.

[0078] In addition, if Figure 12 As shown, the centrifugal device further includes a housing 705, which is disposed over the centrifugal disc 701, the rotating plate 702, and the rotating drive member 703. The housing 705 is provided with a closable opening 7051. A cover plate and a cylinder may be disposed over the opening 7051, and the cylinder drives the cover plate to move to open and close the opening 7051.

[0079] In some examples, combined Figure 2 , further comprising a sampling assembly 80, which comprises a tip rack 801, a pipette 802, and a fourth movable drive member 803. A plurality of tips 8011 are arrayed on the tip rack 801, and the pipette 802 is disposed above the tip rack 801 and connected to the fourth movable drive member 803. The fourth movable drive member 803 drives the pipette 802 to move between one of the transfer assemblies 20 and the tip rack 801 so that the pipette 802 aspirates liquid or replaces the tip 8011. It is understandable that a transfer assembly 20 and a screw cap assembly 40 are also provided on the sampling assembly 80. The transfer assembly 20 moves the centrifuged test tube to the sampling assembly 80, and the screw cap assembly 40 unscrews the cover, allowing the sampling assembly 80 to take a sample from the test tube.

[0080] The pipette gun 802 adopts the existing structure of automatically replaceable suction tips 8011 .

[0081] In addition, a collection bucket 804 for collecting waste liquid is provided on the side of the tip rack 801, and the pipette gun 802 moves between one of the transfer components 20, the tip rack 801 and the collection bucket 804. The fourth moving drive member 803 can be a slide linear module structure.

[0082] To better understand this embodiment, the workflow of this embodiment is further described below: test tubes containing samples to be tested are stacked on the storage rack 101, and the sample loading assembly 10 loads the stored test tubes with samples. The manipulator 30 simultaneously takes four test tubes from the sample loading assembly 10 and places the test tubes on the transfer assembly 20. The transfer assembly 20 transfers the test tubes to the bottom of the screw cap assembly 40. The screw cap assembly 40 opens the cover of the test tube. The transfer assembly 20 then transfers the tube body to the bottom of the feeding assembly 50 for adding salt or liquid. After that, The transfer assembly 20 then transfers the tube body to the screw cap assembly 40 to screw the cap onto the tube body. Afterwards, the transfer assembly 20 transfers the test tube to the side of the oscillation assembly 60. The robot 30 takes the test tube and sends it to the oscillation assembly 60 for oscillation. Afterwards, the robot 30 takes the shaken test tube and sends it to the centrifuge assembly 70 for centrifugation. After the centrifugation is completed, the robot 30 takes the test tube and sends it to the transfer assembly 20. The transfer assembly 20 transfers the test tube to the screw cap assembly 40 to open the cap of the test tube, and the sampling assembly 80 takes samples.

[0083] The fully automated pre-processing platform integrates all functional requirements for food safety rapid testing pre-processing, including a reagent library, a 5-track sample transport module (transfer component), a capping module, a liquid addition module, an automatic salt addition module, a pipetting module, an oscillation module, and a centrifugation module. It handles operations such as dilution, transfer, volume determination, and liquid separation for various liquid samples, and supports multi-stage dilution preparation. A single loading can handle up to 96 samples, with a maximum centrifugal speed of 4200 r / min. Each module is relatively independent, exhibits minimal mutual interference, and offers high compatibility, continuity, and a fast and stable speed. This improves the quality, efficiency, and accuracy of pre-processing, enabling truly fully automated pre-processing. Furthermore, each component can be operated simultaneously to increase efficiency.

[0084] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like to indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0085] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature identified as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, "plurality" means two or more, unless otherwise specifically defined.

[0086] In the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," "connect," "fixed," etc. should be understood broadly. For example, they may refer to fixed connection, detachable connection, or integration; mechanical connection or electrical connection; direct connection or indirect connection through an intermediate medium; internal communication between two components or interaction between two components. Those skilled in the art will understand the specific meanings of the above terms in the present invention based on specific circumstances.

[0087] In the present invention, unless otherwise expressly specified or limited, a first feature being "above" or "below" a second feature may include the first and second features being in direct contact, or may include the first and second features being in contact not directly but through another feature between them. Furthermore, a first feature being "above," "above," and "above" a second feature may include the first feature being directly above or obliquely above the second feature, or may simply mean that the first feature is higher in level than the second feature. A first feature being "below," "below," and "below" a second feature may include the first feature being directly below or obliquely below the second feature, or may simply mean that the first feature is lower in level than the second feature.

[0088] In the description of this specification, the reference terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" mean that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic expressions of the above terms should not be understood as necessarily referring to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine different embodiments or examples described in this specification.

[0089] Although the embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are illustrative and are not to be construed as limitations on the present invention. A person skilled in the art may change, modify, replace and modify the above embodiments within the scope of the present invention.

Claims

1. A pre-treatment device for testing samples, wherein the test sample is placed in a test tube, and the test tube is covered with a cover, characterized in that: The pre-processing device includes: a sample loading component, a manipulator, a capping component, a feeding component, an oscillating component, a centrifugal component and several transfer components; The sample loading assembly comprises a storage rack and a lifting drive member, wherein the storage rack defines a plurality of accommodating cavities, each of which is open at the top and provided with a through hole at the bottom, wherein a plurality of test tubes are stacked in each of the accommodating cavities, and the lifting drive member comprises a plurality of lift bars, each of which is adapted to be inserted into each of the through holes and lift the test tubes in each of the accommodating cavities to the top of the accommodating cavities; Several transfer assemblies are arranged side by side, and the transfer assemblies are arranged below the screw cap assembly and the feeding assembly. Each transfer assembly includes a first clamping member and a first moving drive member. The first clamping member is provided with a plurality of first clamping openings for simultaneously clamping the tube bodies of a plurality of test tubes. The first moving drive member is connected to the first clamping member to drive the first clamping member to move the test tubes. The manipulator is provided with a plurality of adsorption components for simultaneously adsorbing a plurality of test tubes and transferring the test tubes between the loading component, the plurality of transfer components, the shaking component and the centrifugal component; The capping assembly comprises a second clamping member and a capping driving member, wherein the second clamping member is provided with a plurality of second clamping openings for simultaneously clamping the caps of a plurality of test tubes, and the capping driving member is connected to the second clamping member to drive the second clamping member to drive the cap to unscrew or screw on the tube body; The feeding assembly is suitable for adding liquid or salt into the test tube with the lid unscrewed; The oscillating assembly comprises a test tube rack and a first lifting drive member, wherein the test tube rack is provided with a plurality of test tube storage slots, and the first lifting drive member is adapted to drive the test tube rack to move upward and downward; The centrifugal assembly comprises a centrifugal disc, a plurality of rotating plates, and a rotary drive member; the centrifugal disc is circumferentially provided with a plurality of mounting slots; the plurality of rotating plates are correspondingly disposed in the plurality of mounting slots and each of the rotating plates is rotatable in the mounting slots with a rotating shaft as a fulcrum; at least one placement tube for placing a test tube is disposed on the rotating plate; the rotary drive member is connected to the centrifugal disc to drive the centrifugal disc to rotate; when the centrifugal disc rotates, each of the rotating plates rotates, causing the placement tube to switch from an upright state to a horizontal state; The second clamping member comprises a plurality of first clamping fingers, a plurality of second clamping fingers, a second movable driving member, and a second lifting driving member. The plurality of first clamping fingers and the plurality of second clamping fingers correspond to each other one by one to jointly form a plurality of second clamping openings. The plurality of first clamping fingers are connected to the rotating driving member, and the plurality of second clamping fingers are connected to the movable end of the second lifting driving member. The second lifting driving member is disposed on the movable end of the second movable driving member. The oscillation assembly includes a limiting portion and a first movable pair; the limiting portion includes a limiting plate and a third movable driving member, the limiting plate is suitable for abutting against the cover of the test tube of the test tube rack, and the third movable driving member is arranged on the test tube rack and connected to the limiting plate to drive the limiting plate to move to abut against or leave the cover; the first movable pair is arranged upright, and the slider of the first movable pair connects the test tube rack and the first lifting driving member.

2. The pre-treatment device for detecting a sample according to claim 1, wherein: A plurality of accommodating cavity arrays are arranged on the storage rack.

3. The pre-treatment device for detecting a sample according to claim 1, wherein: The first clamping opening of the first clamping member is constructed by an air clamp.

4. The pre-treatment device for detecting a sample according to claim 1, wherein: The rotary cover assembly further includes a third lifting drive member and a support plate. The rotary cover drive member is disposed on the support plate. The third lifting drive member is connected to the support plate to drive the second clamping member to move up and down to contact the cover body.

5. The pre-treatment device for detecting a sample according to claim 1, wherein: There are a plurality of both the rotary cover assembly and the feeding assembly, and the plurality of the rotary cover assemblies are arranged in a one-to-one correspondence with the plurality of the feeding assemblies.

6. The pre-treatment device for detecting a sample according to claim 1, wherein: The first lifting drive component includes a motor, a first connecting rod and a second connecting rod, one end of the first connecting rod is connected to one end of the second connecting rod, the other end of the first connecting rod is connected to the power output shaft of the motor, and the other end of the second connecting rod is connected to the slider.

7. The pre-treatment device for detecting a sample according to claim 1, wherein: It also includes a sampling component, which has a tip rack, a pipette and a fourth movable driving component. A plurality of tips are arranged in an array on the tip rack. The pipette is arranged above the tip rack and connected to the fourth movable driving component. The fourth movable driving component drives the pipette to move between one of the transfer components and the tip rack so that the pipette can aspirate liquid or replace the tip.

8. The pre-treatment device for detecting samples according to claim 7, characterized in that: A collecting bucket suitable for collecting waste liquid is provided on the side of the tip rack, and the pipette gun moves between one of the transfer components, the tip rack and the collecting bucket.

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