Injection device and method for aquatic species

Abstract

An injection device (10) includes a hand-held unit (100) having a head (102) and a body portion (104). The head includes a needle (110), a support portion (116), a movable portion (118), and a safety cap (122) removably coupled to the head. The movable portion moves axially relative to the support portion between an extended position and a retracted position in which a distal point of the needle is exposed. The safety cap includes a base member (123) and a locking plate (124) pivotably coupled to the base member, the locking plate pivotable between a locked position in which axial movement of the safety cap and the movable portion relative to the needle is restricted and an unlocked position in which the safety cap and the movable portion are axially movable relative to the needle.

Description

[0001] Cross-reference to related applications

[0002] This application claims priority to U.S. Provisional Application No. 63 / 066,026, filed August 14, 2020, the entire contents of which are incorporated herein by reference. Technical Field

[0003] This disclosure relates to an injection device for administering one or more drugs to a subject (specifically, an aquatic species including fish or a domesticated animal or companion animal (e.g., poultry, pigs, cattle, sheep, goats, ungulates, cats, and dogs)). Background Technology

[0004] In aquaculture, aquatic species (e.g., aquatic organisms such as fish, crustaceans, mollusks, algae, aquatic plants, marine animals, and other organisms) often require the administration of substances such as medications for various reasons. Producers must handle large quantities of aquatic species, and handling may require injecting each aquatic organism with multiple medications, usually in liquid form. These medications can include drugs, vaccines, hormones, food supplements, etc. (collectively referred to as "medications"). The administration of such medications typically involves the use of administration equipment, such as syringes or dosing units, to deliver the drug dose to the animals, either manually or automatically. This type of administration usually involves manual actuation or pumping of the equipment to deliver the drug to the animal.

[0005] Handling large numbers of aquatic organisms (e.g., via manually actuated equipment) can lead to operator fatigue, which can result in a number of failures, including: (i) accidental self-injection by the operator; (ii) administering a drug dose before the needle has penetrated the subject's skin or reached the desired depth; (iii) administering the dose after the needle has been removed from the subject; (iv) administering only a portion of the required dose; (v) inserting the needle into the subject in an unoptimal orientation; and / or (vi) administering repeated doses to the same individual.

[0006] Furthermore, in some cases, it is necessary to administer more than one drug to a single aquatic organism. When there are no readily available combinations of different drugs, or when it is impossible to combine two or more drugs together, each subject must undergo more than one injection, which can lead to operator fatigue.

[0007] Therefore, there is a continuous need for improved syringe equipment and its usage methods, for example, equipment for injecting one or more drugs into large numbers of aquatic species. Summary of the Invention

[0008] This article describes embodiments of an injection device for administering one or more drugs to subjects (specifically, aquatic species, such as fish or marine animals). This injection device can be used to administer drugs to a large number of subjects in a rapid and efficient manner to prevent and / or reduce operator error, operator fatigue, and injection malfunctions.

[0009] In a representative embodiment, an injection device may include a handheld unit having a head and a body portion. The head includes a needle, a support portion, and a movable portion. The movable portion is axially movable relative to the support portion between an extended position and a retracted position, in which the distal point of the needle is exposed. The injection device may also include a safety cap removably coupled to the movable portion. Some embodiments of the safety cap include a base member and a locking plate pivotally coupled to the base member. The locking plate is pivotable between a locked position and an unlocked position, in which axial movement of the safety cap and the movable portion relative to the needle is restricted, and in the unlocked position, the safety cap and the movable portion are axially movable relative to the needle.

[0010] Some embodiments of the safety cap may also include a first clamping member and a second clamping member, extending from the base member and configured such that positioning a subject between the clamping members aligns a selected injection site on the subject with a distal point of the needle. The clamping members are movable between an open position and a gripping position, in which the clamping members are configured to grip the subject.

[0011] The safety cover may also include a biasing member configured to bias the locking plate to the locking position.

[0012] The injection device may also include a needle support portion configured to releasably engage a needle to a body portion. In these embodiments, a locking plate includes a locking member extending from the locking plate and having a locking surface configured to engage a corresponding locking surface on the needle support portion when the locking plate is in a locked position.

[0013] The safety cover may also include an annular protrusion having a threaded outer surface configured to engage a corresponding threaded surface of a connector, which is then engaged with the movable portion.

[0014] The locking plate may also include a hole extending through the thickness of the locking plate. This hole is aligned with the needle such that at least a portion of the needle extends through the hole when the movable portion is in the retracted position. The injection device may also include a removal member disposed within the hole. The removal member includes a pinhole extending through the thickness of the removal member. The pinhole is sized such that the inner surface of the removal member contacts the outer surface of the needle to remove contaminants from the outer surface of the needle.

[0015] The injection device may also include at least one control unit, which is located remotely from the handheld unit and fluidly coupled to the handheld unit via one or more connecting tubes. The control unit may include a pump. In some embodiments, the control unit is configured to be worn by a user.

[0016] The handheld unit can be configured to be submerged in water.

[0017] The movable part may also include a locking mechanism that is movable between a locked position and an unlocked position. In the locked position, the movable part is restricted from moving to a retracted position, and in the unlocked position, the movable part is movable between an extended position and a retracted position. The locking mechanism may be configured to be actuated by any convenient method, for example, by a trigger coupled to the main body.

[0018] The injection device can be configured to operate in at least an automatic mode and a manual mode, and switch between them. When the device is in automatic mode, medication can be administered automatically when the needle is inserted into the subject at a selected depth. When the device is in manual mode, medication is administered when the operator actuates a trigger connected to the main body.

[0019] In another representative embodiment, an injection device may include a base station comprising a substrate, an upper member coupled to the substrate, and a head removably coupled to the upper member. The head includes a needle, a support portion, and a movable portion. The movable portion is axially movable relative to the support portion between an extended position and a retracted position, in which a distal point of the needle is exposed. The disclosed embodiments of the device may also include a safety cap removably coupled to the upper member. The safety cap includes a base member and a locking plate pivotally coupled to the base member. The locking plate is pivotable between a locked position and an unlocked position, in which axial movement of the safety cap and the movable portion relative to the needle is restricted, and in the unlocked position, the safety cap and the movable portion are axially movable relative to the needle.

[0020] The injection device may include at least one control unit located remotely from the base station and fluidly connected to the upper component via one or more connecting pipes. The at least one control unit includes a pump. The upper component may be configured to communicate with the control unit via a communication cable.

[0021] The base station and security cover can be submerged in water.

[0022] The safety cap may also include a biasing member configured to bias the locking plate to a locked position. The injection device may also include a needle support portion configured to releasably engage a needle to the body portion. The locking plate may include a locking member extending from the locking plate and having a locking surface configured to engage a corresponding locking surface on the needle support portion when the locking plate is in the locked position.

[0023] The invention also includes a method comprising providing a disclosed embodiment of an injection device and administering a drug to a subject using the device. In a representative embodiment, a method of using the injection device may include: pushing a locking plate against a selected implantation site on the subject, thereby pivoting the locking plate from a locked position to an unlocked position; actuating a movable portion to move the movable portion and a safety cap relative to the needle, thereby exposing a distal point of the needle; and administering the drug when the distal point of the needle has reached a selected depth within the subject. The method may further include a first clamping member and a second clamping member extending from a base member such that the selected injection site on the subject is aligned with the distal point of the needle.

[0024] The movable portion may further include a locking mechanism capable of moving between a locked position and an unlocked position, wherein in the locked position, the movable portion is restricted from moving to a retracted position, and in the unlocked position, the movable portion is capable of moving between an extended position and a retracted position. Therefore, the method may further include an actuation trigger operatively coupled to the locking mechanism to move the locking mechanism to the unlocked position.

[0025] In another representative embodiment, a method may include providing an injection device comprising: a head having a needle, a support portion, and a movable portion axially movable relative to the support portion between an extended position and a retracted position, in which a distal point of the needle is exposed; and a safety cap removably coupled to the movable portion, the safety cap including a base member and a locking plate pivotally coupled to the base member, the locking plate pivoting between a locked position and an unlocked position, in which axial movement of the safety cap and the movable portion relative to the needle is restricted, and in the unlocked position, the safety cap and the movable portion are axially movable relative to the needle. The method may further include pressing the locking plate against a selected injection site on a subject, such that the locking plate pivots to the unlocked position. The movable portion is actuated to insert the distal point of the needle into the subject. When the distal point of the needle has reached a selected depth within the subject, a drug is administered.

[0026] The method may further include positioning a selected injection site of the subject between a first clamping member and a second clamping member extending from the base member, so that the selected injection site is aligned with a distal point of the needle. The method may also include gripping the subject using the first clamping member and the second clamping member.

[0027] The movable portion may also include a locking mechanism that is movable between a locked position and an unlocked position, wherein in the locked position the movable portion is restricted from moving to a retracted position and in the unlocked position the movable portion is movable between an extended position and a retracted position. The method may also include an actuation trigger operatively coupled to the locking mechanism to move the locking mechanism to the unlocked position.

[0028] In some embodiments, the head is coupled to a body portion to form a handheld unit configured to be carried by an operator. In other embodiments, the head is coupled to a base station, which includes a substrate and an upper member coupled to the substrate, and the base station is configured to be coupled to a surface.

[0029] In one representative embodiment, an injection device may include a handheld unit having a head and a body portion. The head may include: a base member; a needle fluidly coupled to the base member; a movable portion disposed on the needle and axially movable relative to the base member between an extended position and a retracted position, in which a distal point of the needle is exposed; a safety cap removably coupled to the base member, the safety cap including one or more extension members; and an adjustment member removably coupled to the movable portion and configured to adjust the needle insertion depth by increasing or decreasing the distance between the movable portion and the base member. Attached Figure Description

[0030] Figure 1 A perspective view of an exemplary injection device.

[0031] Figure 2 for Figure 1 A perspective view of the head of the injection device.

[0032] Figure 3 for Figure 1 A cross-sectional perspective view of the head of the injection device.

[0033] Figure 4 for Figure 1 An exploded view of the handheld unit of the injection device, with the safety cover removed.

[0034] Figure 5 In order to maintain the exemplary subject's Figure 1 A perspective view of the head of the injection device.

[0035] Figure 6 To be shown in the extended and locked position Figure 2 A cross-sectional view of a portion of the head.

[0036] Figure 7 To be shown as being in the retracted and unlocked positions Figure 2 A cross-sectional view of a portion of the head.

[0037] Figure 8 A perspective view of an exemplary head of an injection device.

[0038] Figure 9 A perspective view of removing a component as an example.

[0039] Figure 10 A top view of an exemplary safety cap of an injection device shown in the gripping position.

[0040] Figure 11 To be shown as being in the open position Figure 10 A top view of the safety cover.

[0041] Figure 12 A side view of an operator wearing an exemplary injection device.

[0042] Figure 13 A perspective view of an exemplary injection device.

[0043] Figures 14 to 15 A perspective view of an exemplary head of an injection device.

[0044] Figure 16 for Figure 14 An exploded perspective view of the head.

[0045] Figures 17 to 18 for Figure 14 A perspective view of the base component of the head.

[0046] Figure 19 for Figure 14 A perspective view of the supporting components of the head.

[0047] Figures 20 to 21 for Figure 14 A perspective view of the head adjustment component.

[0048] Figure 22 for Figure 14 A perspective view of the movable part of the head.

[0049] Figure 23 for Figure 14 A perspective view of the safety cap on the head.

[0050] Figure 24 for Figure 14 A perspective view of the head.

[0051] Figure 25 for Figure 14 A perspective view of the head, with the movable parts removed.

[0052] Figure 26 for Figure 14A perspective view of the head, where the movable portion is shown in a retracted configuration.

[0053] Figure 27 for Figure 14 A perspective view of the head, including another exemplary embodiment of the safety cover.

[0054] Figure 28 for Figure 14 A side view of the head.

[0055] Figure 29 For intercepting along line AA Figure 28 A cross-sectional view of the head.

[0056] Figure 30 for Figure 14 A side view of the head.

[0057] Figure 31 For intercepting along line BB Figure 30 A cross-sectional view of the head. Detailed Implementation

[0058] I. Definition

[0059] This document describes some aspects, advantages, and novel features of the disclosed embodiments. The embodiments of the disclosed apparatus, systems, and methods should not be construed as limiting in any way. Rather, this disclosure relates to all novel and non-obvious features and aspects of the various disclosed embodiments, individually and in various combinations and sub-combinations with each other. The apparatus, systems, and methods are not limited to any particular aspect or feature or combination thereof, and the disclosed embodiments do not claim to have any one or more particular advantages or solve any one or more particular problems.

[0060] Although the operations of some disclosed embodiments are described in a specific, sequential order for ease of presentation, it should be understood that this descriptive method includes rearrangement unless the specific language described below requires a particular order. For example, operations described sequentially may be rearranged or performed concurrently in some cases. Furthermore, for simplicity, the accompanying drawings may not show various ways in which the disclosed methods can be used in conjunction with other methods. Additionally, the description sometimes uses terms such as “provide” or “implementation” to describe the disclosed methods. These terms are high-level abstractions of the actual operations performed. The actual operations corresponding to these terms may vary depending on the specific implementation and are readily understood by those skilled in the art.

[0061] As used in this application and claims, the singular forms “a,” “an,” and “the” include the plural forms unless the context clearly specifies otherwise. Furthermore, the term “comprising” means “including.” Further, the term “link” generally means a physical, mechanical, chemical, magnetic, and / or electrical connection or link, and in the absence of specific contrasting language, the presence of intermediate elements is not excluded between linked or associated items.

[0062] As used herein, the term "proximal" refers to a location, orientation, or portion of the device that is closer to the operator and further away from the application site. As used herein, the term "distal" refers to a location, orientation, or portion of the device that is further away from the operator and closer to the application site. Thus, for example, proximal movement of the device is movement of the device away from the application site and toward the operator (e.g., away from the subject's body), while distal movement of the device is movement of the device away from the operator and toward the application site (e.g., into the subject's body). Unless otherwise explicitly defined, the terms "longitudinal" and "axial" refer to axes extending in the proximal and distal directions.

[0063] In descriptions, certain terms may be used, such as "up," "down," "above," "below," "horizontal," "vertical," "left," "right," etc. Where applicable, these terms are used to provide a clear description when dealing with relationships. However, these terms do not imply absolute relationships, positions, and / or orientations. For example, regarding an object, simply flipping the object over can turn the "upper" surface into the "lower" surface. However, it is still the same object.

[0064] Unless otherwise stated, the disclosure of numerical ranges should be understood to refer to each discrete point within the range, including the endpoints. Unless otherwise stated, all figures used in the specification or claims representing amounts of components, molecular weights, percentages, temperatures, times, etc., should be understood to be modified by the term "about". Therefore, unless otherwise implied or expressly indicated, or unless the context is correctly understood by one of ordinary skill in the art to have a more explicit interpretation, the numerical parameters presented are approximations of detection limits that may depend on the desired characteristics sought and / or standard test conditions / methods known to one of ordinary skill in the art. When examples are directly and explicitly distinguished from the prior art discussed, example numbers are not approximations unless the word "about" is used. As used herein, the term "about" means that the listed value still produces the functional results associated with that value and may be within 10% of the listed value. For example, "about 100 degrees" means at least any value between 90 and 110 degrees, including 90 and 110 degrees.

[0065] As used herein, the term "medicine" refers to any substance that can be administered to a subject. Specific embodiments include, but are not limited to, antibiotics, vaccines, therapeutic agents, hormones, food supplements, oils, vitamins, minerals, etc. In some embodiments, the medicine is in liquid form. In other embodiments, the medicine may be in powder form and may be mixed with one or more liquids or solvents in two or more containers or prior to being placed therein to form a suspension or solution. Specific exemplary medicines include, but are not limited to: STREP INIAE, STREP AGALACTIAE, ALPHA JECT 1Noda, ALPHA 2000.Alpha ERM Salar,ALPHA JECT 7IL, ALPHA JECT 6. VNN, Irido V Strep SA and its combinations.

[0066] As used in this article, the term "subject" refers to a human or animal subject who has undergone treatment, observation, or experimentation.

[0067] The term "animal" can refer to aquatic animals, terrestrial animals, birds, or amphibians. For example, animals may include, but are not limited to: poultry, pigs, cattle, sheep, goats, horses, deer, felines, canines, and / or aquatic species including fish. Cattle can be dairy cows or animals raised for beef. Animals can include animals raised for human consumption or domesticated animals. Examples of animals that can be injected using the disclosed injection device embodiments include, but are not limited to: ruminant species such as sheep, goats, cows, heifers, bulls, calves, castrated bulls, deer, bison, buffalo, elk, alpacas, camels, or llamas; ungulates such as horses, donkeys, or pigs; birds such as chickens, including laying hens and broilers, turkeys, geese, ducks, Cornish pheasants, quails, partridges, pheasants, guinea fowl, ostriches, emus, swans, or pigeons; aquatic animals such as aquaculture species such as fish (e.g., salmon, trout, tilapia, sea bream, carp, cod, halibut, snapper, herring, catfish, flounder, halibut, hake, smelt, anchovies, large fish resembling flounder, moi, perch). Orange seabream, sea bass, tuna, mahi-mahi, mackerel, eel, barracuda, blue tuna, Atlantic sea bass, Nile perch, Arctic char, haddock, longtail cod, Alaskan pollock, turbot, freshwater pufferfish, glass pikeperch, ray, sturgeon, Dover sturgeon, common sturgeon, wolffish, sablefish, American herring, sea bream, grouper, monkfish, pomfret, lake whitefish, tilefish, spiny mackerel, single-finned cod, bowfin, eel, moonfish, gray mackerel, swordfish, cobia, yellow croaker or their hybrids, etc.), crustaceans (such as lobster, shrimp, prawn, crab, krill, crayfish, barnacles, copepods, etc.) or mollusks (such as squid, octopus, abalone, whelk, rock snail, whelk, clam, oyster, mussel, clam, etc.). Alternatively or alternatively, the animals may be companion animals, such as canines; felines; rabbits; rodents, such as rats, mice, hamsters, gerbils, guinea pigs, or chinchillas; birds, such as parrots, canaries, magpies, finches, cockatoos, macaws, magpies, or Australian parrots; reptiles, such as snakes, lizards, turtles, or aquatic turtles; fish; crustaceans; and amphibians, such as frogs, toads, and salamanders.

[0068] As used herein, the terms “food supplement,” “dietary supplement,” and “feed additive” can refer to products intended to supplement the diet of the subjects. Food supplements may contain, but are not limited to, vitamins, fatty acids, probiotics, minerals, amino acids, enzymes, herbs and botanicals (including plant materials, algae, macrofungi, and combinations thereof), and other substances.

[0069] II. Exemplary Embodiments

[0070] This document discloses embodiments of an injection device for administering one or more drugs simultaneously or sequentially to a subject (e.g., an aquatic species, including fish). Although the following embodiments of the injection device are described with regard to its use in aquatic species (e.g., fish), it should be understood that the embodiments disclosed herein can be used for any of a variety of subjects.

[0071] Figures 1 to 7 An exemplary embodiment of the injection device 10 is shown, which includes a handheld unit 100, the handheld unit including an interchangeable head 102 removably coupled to a body portion 104. Figures 14 to 20 (See head 500 shown). In some embodiments, the injection device 10 is used to inject one or more drugs into a subject. Reference Figure 1 The disclosed injection device embodiment 10 may include: a handheld unit 100; at least one control unit 200 fluidly connected to the handheld unit via at least one connecting tube 202; and one or more drug containers 300 removably connected to at least one control unit 200 and / or the handheld unit 100 via one or more connecting tubes 202. In other embodiments, the container 300 may be directly connected to the handheld unit 100 and / or the control unit 200.

[0072] The injection device 10 may be a modular device in which each component (e.g., the handheld unit 100, head 102 and / or 500, body portion 104, control unit 200, container 300) is interchangeable and / or replaceable. For example, the injection device 10 may be provided as a component or kit and may be packaged together for delivery to the end user. An exemplary kit may include the body portion 104, one or more control units 200, one or more containers 300, a flexible tube 202, and one or more heads 102 and / or 500. In some embodiments, each provided head 102 and / or 500 may be configured specifically for different types of subjects (e.g., aquatic species, poultry, pigs, etc.). Details of additional heads for poultry, pigs, and / or other subjects can be found at least in International Application PCT / IB2020 / 053177 and International Publication WO 2019 / 116229, the entire contents of which are incorporated herein by reference. In other embodiments, each kit may include multiple heads 102 such that if a head 102 is damaged and / or worn, the head 102 can be replaced.

[0073] Replacement or additional components (e.g., additional heads 102, 500 and / or an additional pump for the control unit 200) may also be provided separately from the kit to replace components of the modular injection device 10. This modular configuration advantageously allows the injection device 10 to be used for a variety of purposes, including for a variety of subjects. The modular configuration also allows the operator to switch between heads 102, 500 (and thus between needle types, e.g., between needles of different lengths and / or widths, between hypodermal or intradermal needles, between fixed and movable needles, and so on), and / or replace damaged needles or heads, for example, in the field or in an operational setting. This configuration allows the operator to mitigate interruptions to the injection process caused by broken needles or damaged and / or clogged heads. In some embodiments, the control unit 200 may also include a replaceable pump that can be removed and replaced without the use of tools.

[0074] As described above, the handheld unit 100 may include interchangeable heads 102 and / or 500 removably coupled to the main body portion 104. Figure 5 As shown, the heads 102 and 500 can be configured for use with subjects such as aquatic species including fish. The main body 104 may include a gripping portion 106 for an operator to hold. The handheld unit 100 may also include a lamp 105 coupled to, for example, the main body 104.

[0075] The head (e.g., head 102 and / or 500) may include connector 108. Figure 4 The connector is configured to engage a corresponding connector of the body portion 104. For example, connector 108 may have an internal threaded surface configured to engage an external threaded surface of the body portion, and vice versa. To remove and / or replace heads 102, 500, connector 108 may be rotated in a first direction (e.g., counterclockwise) such that the threads of connector 108 disengage from body portion 104, thereby disengaging heads 102, 500 from body portion 104. Connector 108 may be rotated in a second direction (e.g., clockwise) to engage head 102 (or a replacement head or alternative head) to body portion 104. In other embodiments, head 102 may be engaged to body portion 104 using, for example, any suitable connector or connection system (e.g., snap-fit ​​connection, clamp) or other mechanical means (e.g., screws, etc.).

[0076] refer to Figures 2 to 3 The head 102 may include one or more needles 110 configured to administer medication to a subject. In the illustrated embodiment, as shown... Figure 3 As shown, the head 102 includes a needle 110; however, in other embodiments, the head 102 may include two or more needles. Figure 4An exploded view of the handheld unit 100 is shown; for illustrative purposes, the security cover 122 has been removed. (Reference) Figure 4 The needle 110 is fluidly connected to the connecting tube 112 via a needle support portion 114, which includes, for example, a Luer lock configured to releasably engage the needle 110. The connecting tube 112 is fluidly connected to the body portion 104 and the container 300 via a control unit 200.

[0077] The head 102 may include a support portion 116 and a movable portion 118. The movable portion 118 may be axially movable relative to the support portion 116 in a telescopic manner, as indicated by arrow 120. The movable head 118 may be in an extended position (e.g., see...). Figure 3 ) and retraction position (e.g., see Figure 7 The movable head 110 moves between the extended and retracted positions. In the extended position, the distal point of the needle (e.g., the distal edge) is covered by the safety cap 122, and in the retracted position, the distal point of the needle 110 is exposed. In some embodiments, the movable head 118 may include a biasing member (e.g., a spring, a compressible sleeve, etc.) configured to bias the movable head to the extended position. The needle support portion 114 (and therefore the needle 110) may be coupled to the body portion 104 and / or the support portion 118 such that the movable portion 118 is movable relative to the needle 110.

[0078] Pushing the movable portion 118 rearward (e.g., proximally) relative to the support portion 116 exposes the distal point of the needle 110 and allows the needle to be inserted into the subject's body. In some embodiments, pushing the movable portion 118 rearward into a retracted position (e.g., by pressing the movable portion 118 against a selected injection site on the subject) triggers the release of a predetermined dose of medication (e.g., by opening a valve associated with the needle and / or by triggering movement of a pump within the control unit 200). The movable portion 118 may also include a locking mechanism configured to prevent movement of the movable portion 118 relative to the support portion 116 when engaged. The locking mechanism may be operatively coupled to the trigger 103 ( Figure 4 This causes the actuation (e.g., pressing) trigger 103 to disengage the locking mechanism and allow the movable portion 118 to move relative to the support portion 116. Further details of the movable portion and the support portion can be found, for example, in international application PCT / IB2020 / 053177.

[0079] Refer again Figures 2 to 3 The needle 110 may be covered by a safety cover 122, which is removably coupled to the movable portion 118 (e.g., via connector 142). The safety cover 122 may be configured to selectively cover the needle 110 and may include a base 123, a locking plate 124, and two clamping members 126 extending distally from the safety cover 122.

[0080] In the illustrated embodiment, such as Figure 5 As shown, each clamping member 126 has an elongated U-shaped form; however, in other embodiments, the clamping members may have any of a variety of shapes, including but not limited to rectangular, square, triangular, etc. In use, the operator can position the subject between the two clamping members 126 to align the subject with the hole 133 in the locking plate 124, and thus with the needle 110, such that the needle 110 is inserted into the subject 128 at the selected injection site. Figure 5 As shown, for fish, the selected injection site can be on the abdomen between the lateral fins.

[0081] In some embodiments, the clamping members 126 may be flexible members and may be biased inward such that they grip a subject positioned between them. For example, the clamping members 126 may include a self-biasing or resilient material (e.g., steel, plastic, rubber, etc.). In such embodiments, the clamping members 126 may be configured to be biased to an open or gripping position without using a separate biasing member. In other embodiments, the clamping members 126 may be pivotally coupled to the safety cover 122 and movable between an open position and a gripping position. In such embodiments, the clamping members 126 may include a biasing member (e.g., a spring) configured to bias the clamping members to the gripping position. In some embodiments, the clamping members 126 may be moved between the open and gripping positions using, for example, a trigger 103.

[0082] refer to Figures 6 to 7 The locking plate 124 can be in the locked position ( Figure 6 ) and unlock location ( Figure 7 The safety cover 122 and the movable portion 118 are movable relative to the pin 110 in the locked position, and in the unlocked position, the safety cover 122 and the movable portion 118 are movable relative to the pin 110. The locking plate 124 may have a first end 130, a second end 132, and a hole 133 extending through the thickness of the locking plate 124. The first end 130 may be pivotally coupled to the base 123 via a pivot pin 131 and may include a locking member 134 extending proximally. The locking member 134 may have a locking surface 136. Figure 7 The locking surface is configured to engage the corresponding locking surface 138. Figure 7 This is to prevent the safety cover 122 and the movable part 118 from moving relative to the needle 110. Figures 1 to 7 In the illustrated embodiment, the locking surface 138 may be disposed on the distal portion of the needle support portion 114, such as... Figure 4As shown. However, in other embodiments, the locking surface 138 may be located at any of a variety of positions configured to prevent the safety cap and the movable portion 118 from moving relative to the needle 110.

[0083] The second end 132 of the locking plate 124 can be coupled to a biasing member 140 (e.g., a spring, a compressible sleeve, etc.). The biasing member 140 is configured to bias the locking plate 124 into a locked position. Figure 7 As shown, when a force is applied to the second end 132 in the proximal direction, as indicated by arrow 125, the biasing member 140 is compressed and the locking plate 124 pivots about the pivot pin 131, thereby disengaging the locking surfaces 136, 138 from each other and allowing the movable portion 118 and the safety cover 122 to move relative to the needle 110, such that the distal point of the needle 110 extends through the hole 133 and is exposed.

[0084] The head 102 may also include a sensor (e.g., an optical sensor) configured to detect when the needle 110 has reached a selected depth within the subject 128. Once the sensor determines that the selected depth has been reached, an injection of a predetermined dose of medication can be triggered. In some embodiments, the sensor may further determine whether the full dose of medication has been injected. For example, if the needle 110 is removed from the subject 128 before the full dose is administered, the sensor may trigger an alarm to inform the operator that the injection has failed. This alarm can be any suitable alarm, such as an audible, visual, or tactile alarm (e.g., vibration).

[0085] The safety cover 122 can be removably attached to the movable part 118 via connector 142. For example... Figure 6 As shown, connector 142 may include an internal threaded surface 144. Safety cover 122 may include an annular protrusion 146 having a corresponding threaded external surface 148. To remove safety cover 122, safety cover 122 may be rotated in a first direction (e.g., counterclockwise) such that the thread 144 of connector 142 disengages from the corresponding thread 148 of annular protrusion 146, thereby disengaging safety cover 122 from movable portion 118. To engage safety cover 122 (or an alternative safety cover) to movable portion 118, safety cover 122 may be rotated in a second direction (e.g., clockwise) such that the thread 144 of connector 142 engages with the corresponding thread 148 of annular protrusion 146, thereby engaging safety cover 122 to movable portion 118. In other embodiments, safety cover 122 may be engaged to movable portion 118 via any suitable connector (e.g., snap-fit ​​or clamp connector).

[0086] refer to Figures 8 to 9In some embodiments, the safety cover 122 may also include a removal member 150. The removal member 150 may be coupled to the locking plate 124 and may be configured to remove contaminants, such as dust or scale, adhering to the needle 110. Figure 9 In the illustrated embodiment, the removal member 150 may be an annular member including a pinhole 152 extending through the thickness of the member 150. Figure 8 As shown, component 150 can be configured (e.g., sized and shaped) to fit within hole 133 of locking plate 124. Center hole 152 may have a diameter slightly wider than the outer diameter of needle 110, such that when needle 110 retracts through hole 152, the inner surface of hole 152 contacts the outer surface of needle 110 to remove contaminants (e.g., dust, scale, etc.) from the surface of needle 110.

[0087] In other embodiments, the hole 133 of the locking plate 124 may have any of a variety of shapes (e.g., square, rectangular, oval, triangular, square-elliptical, etc.), and the removal member 150 may have a corresponding shape so that it can be fitted into the hole 133. Although in Figures 8 to 9 In the illustrated embodiment, the pinhole 152 is shown to have a circular shape and is located at the center of the removal member 150; however, it should be understood that the pinhole may be located anywhere within the removal member and may have any shape configured to correspond to the outer periphery of the needle 110.

[0088] refer to Figures 10 to 11 In some embodiments, the clamping member 126 may be pivotally coupled to the base 123 of the safety cover 122, allowing it to be in an open position about a corresponding pivot pin 154. Figure 11 ) and grip position ( Figure 10 The clamping members 126 can move relative to each other. As shown, each clamping member 126 may include a toothed base portion 156 configured to engage a corresponding toothed base portion 156 of an adjacent clamping member 126. The clamping members 126 may be coupled to a biasing member (e.g., a spring) configured to bias the clamping member 126 to a gripping or open position. Thus, once the subject 128 is positioned between the clamping members 126, the clamping members 126 can hold the subject 128 in a selected position for injection.

[0089] As shown in the figure, the clamping member 126 may have a curved sinusoidal shape, including a first curved portion 158 and a second curved portion 160. In other embodiments, the clamping member 126 may have any of a variety of other shapes, for example, Figures 2 to 5The embodiment shows an elongated U-shaped shape. In some embodiments, the clamping member 126 may include a self-biasing or resilient material (e.g., steel, plastic, rubber, etc.). In such embodiments, the clamping member 126 may be configured to be biased to an open or gripping position without using a separate biasing member.

[0090] In other embodiments, the clamping members 126 may be configured to slide relative to each other, rather than rotate about the pivot pin 154. For example, each clamping member 126 may slide toward and away from the longitudinal axis of the handheld unit 100 (e.g., an axis extending along the length of the needle). The clamping members 126 may slide toward each other to a gripping position and / or away from each other to an open position. The clamping members 126 may be coupled to a biasing member (e.g., a spring) configured to bias the clamping members 126 toward each other to the gripping position. Once the subject 128 is positioned between the clamping members 126, the clamping members 126 can be biased to the gripping position and hold the subject in a selected position for injection.

[0091] As described above, the head 102 is removably coupled to the handheld unit 100, which can be coupled to one or more control units 200 and / or one or more drug containers 300. Each control unit 200 can be configured to deliver a dose of medication from a corresponding drug container 300 to the handheld unit 100 and into the subject 128. The control unit 200 may include at least one pump comprising a dosage chamber fluidly coupled to one or more containers 300 via a first check valve and fluidly coupled to the handheld unit via a second check valve. A dose of medication may enter the dosage chamber from the drug container 300 via the first check valve and exit the dosage chamber via the second check valve to reach the handheld unit 100. The pump can be configured to push / pull the same or different amounts (e.g., dosages) of medication from each container 300 and deliver these amounts to the handheld unit 100. In some specific embodiments, the injection device 10 may be designed to deliver a dose of medication of approximately 0.05 ml to approximately 3 ml to each subject in each injection.

[0092] In some embodiments, each control unit may include two or more pumps, wherein the number of pumps is the same as the number of containers 300, and each pump is coupled to a separate container 300. In this configuration, each pump is designed to pull and / or push a predetermined amount of medication from its corresponding container 300 and sequentially deliver the medication to the handheld unit 100 and into the subject's body according to a predetermined administration sequence.

[0093] Refer again Figure 1The control unit 200 may also include a control panel 204. The control panel 204 may include an input device (e.g., a keyboard and / or touchscreen) and / or a display configured to show information about the injection process. In some embodiments, the control panel 204 may be manually actuated by a user. Alternatively, the control panel may be remotely controlled via a remote device (e.g., a handheld mobile device using a smartphone or tablet application). The control unit 200 may be configured to receive and store a selected drug volume input by the operator using the control panel, and may adjust the motor and pump such that the selected drug volume is injected with each injection.

[0094] The injection device 10 may also include a power source configured to allow the injection device 10 to be used in remote areas with limited power supply. Any suitable power source can be used, including, but not limited to, battery packs, solar panels, hydrogen fuel cells, etc. Combinations of power sources can also be used, where the power sources can be identical, such as two battery packs, or different, such as a solar panel and a battery pack. In some embodiments, the power source may be rechargeable. In other embodiments, the power source may be disposable (e.g., a disposable battery). The power source may be removably coupled to the control unit 200 and configured to provide power to the injection device 10. In other embodiments, the power source may be coupled to the handheld unit 100, the container 300, or may be a separate component operatively coupled to the injection device via one or more power cables. In other embodiments, the handheld unit 100 may include a second power source configured to power the handheld unit.

[0095] The control unit 200 may also include one or more cables integrated with or connectable to it. In the illustrated embodiment, cable 206 operatively connects the control unit 200 to the handheld unit 100. Cable 206 is configured to power the handheld unit 100 and / or allow communication between the handheld unit 100 and the control unit 200. For example, when the needle 110 is in position for injection, the handheld unit 100 may send a signal to the control unit 200.

[0096] In some embodiments, the injection device 10 may be configured to inject two or more different drugs into a subject at the same location or at two or more different locations using a single needle. In such embodiments, the injection device may, for example, include three main subsystems: (1) a handheld unit 100 including a single needle; (2) one or more control units 200, each control unit including a pump, one or more check valves, and a power supply; and (3) two or more containers 300 containing different drugs. Further details of this configuration can be found, for example, in WO 2018 / 203203, the entire contents of which are incorporated herein by reference. In other embodiments, the injection device 10 may include multiple needles, each fluidly coupled to a corresponding pump coupled to a corresponding drug container.

[0097] Although the injection device 10 is described with reference to intramuscular injection (e.g., injection perpendicular to the subject's surface), it should be understood that the head 102 and safety cap 122 can also be adapted for subcutaneous injection (e.g., by modifying the angle of the locking plate 124 and / or removing or modifying the clamping member 126). Subcutaneous injection requires the needle to penetrate the patient's skin but stop before penetrating the patient's muscle, allowing the drug to deposit between the skin and muscle. This type of injection requires the needle to enter almost parallel to the skin. As used herein, unless stated in absolute terms such as "perfectly parallel" or "perfectly perpendicular," the terms "parallel" and "perpendicular" include the terms "substantially parallel" and "substantially perpendicular." For example, when an object is oriented at an angle of ±20° or less relative to a reference object or plane, the object is substantially parallel to the reference object or plane, and when the object is oriented at an angle of ±20° or less relative to the reference object or plane, the object is substantially perpendicular to the reference object or plane.

[0098] In some specific embodiments, the injection device 10 is used for subcutaneous injection, and the head 102 can be removed to expose the needle. In such embodiments, manual injection can be used instead of automated injection. For example, an operator can insert the needle substantially parallel to the subject's skin (or scales) and actuate the trigger 103 to start the pump and inject the drug.

[0099] Typically, medications are administered in liquid form. In some embodiments, container 300 contains a spare liquid medication. In other embodiments, the medication to be administered is administered in a dry form (e.g., as a spray powder). In such embodiments, the medication is contained in a dry form within the container. In other embodiments, container 300 contains medication (e.g., in dry or powder form) that requires processing or preparation prior to use (e.g., by adding water, alcohol, or other solvents or suspending agents). Therefore, in some embodiments, container 300 may be internally divided into two or more compartments for containing one or more powdered medications and one or more solvents or suspending agents.

[0100] like Figure 1 As shown, container 300 can be formed independently and can be removably coupled to at least one control unit 200 via one or more connecting tubes 202. In some embodiments, each control unit 200 can be fluidly coupled to a corresponding container 300. Containers can be refilled when emptied or replaced with full containers. In some embodiments, container 300 can be integrally formed with or coupled to handheld unit 100, control unit 200, or both, and can be refilled with a suitable liquid medication when the container is emptied.

[0101] As previously described, control unit 200 may be configured to receive data from and / or transmit data to a remote device. The remote device may be configured to store data from injection device 10, send data to injection device 10, and / or remotely control injection device 10. The remote device may be, for example, a general-purpose computer, a handheld mobile device (e.g., a mobile phone or tablet), and / or any type of accessory thereof (e.g., a “smartwatch”, etc.). The remote device may include an application or “app” configured to control the application process and / or track information related to the application process. In some embodiments, control unit 200 may transmit real-time information to the remote device, which may be displayed by the application. In some embodiments, multiple control units 200 from multiple injection devices 10 may transmit real-time information to the same remote device.

[0102] Further details regarding the power supply, control unit 200, drug compartment 300, remote equipment, computing environment, and graphical user interface can be found, for example, in international application PCT / IB2020 / 053177.

[0103] The injection device 10 can be configured to operate in and switch between various injection modes. For example, the injection device 10 can operate in automatic, manual, and / or semi-automatic modes. The operator can switch between modes, for example, by changing the firmware mode. In some embodiments, the mode can be selected by entering a command on the control unit 200 (e.g., by pressing a “mode selection” button), while in other embodiments, the mode can be selected using a remote device including an application or “app” configured to control the application process.

[0104] When operating in automatic mode, the injection device 10, including the head 102, can be used to administer medication to a subject in the following exemplary manner. The operator can actuate the trigger 103 to release the lock, allowing axial movement of the movable portion 118 relative to the support portion 116. The operator can position the subject 128 between the clamping members 126, such as... Figure 5 As shown, the subject 128 is pushed against the locking plate 124 at the injection site (e.g., between the subject's abdomen and / or the subject's fin). When the subject 128 is pushed against the locking plate 124, the locking plate 124 pivots about the pivot pin 131, such that the locking surfaces 136, 138 ( Figure 7 The safety cap 122 and the movable portion 118 disengage from each other, and move relative to the needle 110, thereby exposing the needle 110 and allowing the distal point of the needle 110 to penetrate the subject 128. Once the distal point of the needle 110 reaches a selected depth within the subject 128 (e.g., determined by a sensor), the injection device 10 can automatically inject the medication. Once a dose of medication has been injected (which may be indicated by some kind of marker, such as a green light or sound), the operator can withdraw the needle 110 from the subject 128.

[0105] When the injection device is switched to manual mode, the operator can select the "manual" firmware mode and secure the movable part 118 and safety cap 122 in the retracted position (e.g., exposing the distal point of the needle 110 from the movable part 118 and safety cap 122). When operating in "manual" mode, regardless of the position of the locking plate 124 and / or the subject 128, whenever the trigger 103 is actuated ( Figure 1 The injection device 10 will inject the drug.

[0106] The injection device 10 can also operate in a "semi-automatic" mode, in which the injection device 10 injects medication only when both the trigger 103 and the locking plate 124 are simultaneously actuated. In semi-automatic mode, the operator can actuate the trigger 103 to inject the medication. For example, the subject 128 can be positioned between the clamping members 126 and pushed against the locking plate, causing the needle 110 to enter the subject at a selected injection site. After the needle is inserted into the subject, the operator can actuate the trigger 103 to inject the medication into the subject. This mode of operation advantageously allows the operator to control the timing of the injection and to inject only when the operator determines that the needle is in the selected position.

[0107] like Figure 12 As shown, in some embodiments, the injection device 10 may be worn and / or carried by an operator. In such embodiments, one or more control units 200 may be configured to be worn by the operator, for example, on a belt, in a waist bag, in a backpack, in a vest, or in a carry-on bag. In other embodiments, one or more control units 200 may be directly coupled to or integrally formed with the handheld unit 100. The drug container 300 may also be worn and / or carried by the operator.

[0108] The connecting tube 202 is flexible enough to allow the operator to move the handheld unit 100, long enough to allow the operator to fully extend their arm to grip the handheld unit 100, and rigid enough (i.e., non-inflatable and non-deformable) to prevent widening of the tube due to pressure generated by the passage of the drug. During drug administration, pressure changes can potentially deform a tube lacking sufficient rigidity, which could lead to inaccurate drug dosing or a delay between pump actuation and drug administration to the animal. In some embodiments, the connecting tube 202 can flex in all directions and can withstand twisting. In some embodiments, the connecting tube can elastically return to its original shape after being bent, twisted, stretched, or otherwise deformed. Further details of the connecting tube and wearable configuration can be found at least in International Application PCT / IB2020 / 053177.

[0109] The injection device 10 can be configured to be submerged in water (e.g., waterproof and / or water-resistant), such that at least the handheld unit 100 can be submerged in an aquatic environment, such as a water tank or aquatic enclosure. In such an embodiment, the operator can immerse the handheld unit 100 in water, positioning the aquatic subject between the clamping members 126, and can push the locking plate 124 against the subject to trigger the injection. This configuration allows the operator to easily inject large numbers of aquatic subjects without having to remove the subject from the water (which would cause panic, agitation, or potential injury).

[0110] refer to Figure 13In other embodiments, the injection device may be configured as a base station injection device 400, with the head 102 removably coupled to it. The base station 400 may include: a substrate 402 that can be coupled to a table or other surface; and an upper member 404 coupled to the substrate 402 and including a needle extending from the upper member 404. The head 102, including a support portion 116, a movable portion 118, and a safety cap 122, may be removably coupled to the upper member 404.

[0111] The upper component 404 is fluidly connected to the control unit 200 via a flexible connecting tube 406, similar to the aforementioned tube 202, and is operatively connected to the control unit 200 via a communication cable 408. The upper component 404 can receive medication from the drug container 300 via the control unit 200 and the connecting tube 406. The upper component 404 can communicate with the control unit 200 via the communication cable 408 (e.g., receiving and / or transmitting data, commands, etc.). In other embodiments, the upper component 404 can wirelessly communicate with the control unit 200 and / or a remote unit. As previously described, the control unit 200 may include at least one pump comprising a dosing chamber fluidly connected to one or more drug containers 300.

[0112] The base station device 400 can be configured to operate in the following exemplary manner. An operator can grasp a first subject 128, position the subject 128 between the clamping members 126, and push the subject 128 against the locking plate 124 of the safety cover 122, as follows: Figure 13 As shown. The subject 128 can be pushed against the locking plate 124 so that the injection site (e.g., the subject's abdomen) is aligned with the target. When the subject 128 is pushed against the locking plate 124, the locking plate 124 pivots about the pivot pin 131, causing the locking surfaces 136, 138 ( Figure 7 The needle 110 is disengaged from the other two parts, and the safety cap 122 and the movable part 118 can move relative to the needle axis, thereby exposing the needle and allowing the distal point of the needle to penetrate the subject 128. Once the distal point of the needle 110 reaches a selected depth within the subject 128 (e.g., determined by a sensor), the injection device 400 can automatically inject the drug. Once a dose of drug has been injected, the operator can withdraw the needle from the subject 128 and release the subject. The operator can then grasp a second subject 128 and repeat the process.

[0113] In another embodiment, the base 400 may be configured for use without the locking plate 124 and / or the movable portion 118. In such an embodiment, an operator can push the subject against the needle, and sensors of the base station 400 (e.g., mechanical, optical, electrical, and / or inductive sensors) can detect when the needle has reached a selected depth within the subject 128, and the injection device can automatically inject the medication.

[0114] The base station 400 may also include one or more indicators 410 (e.g., LEDs) configured to transmit information about the injection process. For example, the indicators may indicate whether the injection was successful, whether the device 400 is ready for subsequent injections, whether an error and / or malfunction has occurred, etc. Figure 13 In the illustrated embodiment, indicator 410 is a visual indicator, such as an LED light. However, in other embodiments, instead of a visual indicator or other than a visual indicator, the indicator may include any suitable indicator, such as a tactile indicator (e.g., vibration) and / or an auditory indicator.

[0115] The base station device 400 can be configured to be submerged in water, allowing it to be placed in aquatic environments, such as water tanks or aquatic enclosures. In such an embodiment, an operator can stand in the water and guide the subject 128 through the water, positioning the subject between the clamping members 126, briefly pushing the subject against the locking plate 124 to trigger the injection, and then releasing the subject 128. This configuration allows the operator to easily inject large numbers of aquatic subjects without having to remove the subjects from the water (which would cause panic, agitation, or potential injury).

[0116] Figures 14 to 31 Another embodiment of the head 500 is shown, which can be coupled to a body portion (e.g., the aforementioned body portion 104) to form a handheld unit 100 of the modular injection device 10 for injecting one or more drugs into a subject. As previously discussed... Figures 1 to 12 According to the embodiments described, the injection device 10 may further include at least one control unit 200 fluidly coupled to the handheld unit 100 and one or more drug containers 300 removably coupled to the at least one control unit 200.

[0117] The head 500 may typically include a support / base member 502, a movable portion 504, a safety cap 506, an adjustment member 508, and one or more needles 510 configured to administer medication to a subject. Figure 16 ).exist Figures 14 to 31 In the illustrated embodiment, the head 500 includes a needle 510; however, in other embodiments, the head 500 may include two or more needles, each of which may be fluidly coupled to the same pump or a corresponding pump. Reference Figure 16 It shows an exploded view of the head 500, and the needle 510 can be accessed via a needle interface 514 including a Luer lock 515. Figure 29 ) fluid connection to connecting pipe 512 ( Figure 17 The needle support 516 surrounds and supports the needle interface 514. The inner bore 513 of the connecting tube 512 is fluidly connected to one or more inlets 518, which are fluidly connected to the drug container 300 via the body portion 104 of the handheld unit 100 and the control unit 200.

[0118] refer to Figures 17 to 18 The base member 502 may include a body 520 having an inner hole 521 (e.g., an annular hole) and an end plate 522, from which an extension member / connecting tube 512 extends. Figure 17 As shown, the connecting tube 512 may include an internally threaded portion configured to engage a Luer lock 515, allowing the needle 510 to fluidly connect to the inner bore 513. Figures 14 to 31 In the illustrated embodiment, the body is cylindrical; however, in other embodiments, the body 520 may have any of a variety of shapes, such as cuboid, oval, etc. Figure 18 As shown, end plate 522 may include a groove 524 in which an inlet 518 may be disposed. In some embodiments, such as the illustrated embodiment, end plate 522 may include various holes 526 through which components of head 500 or body portion 104 may extend, for example, to engage head 500 to body portion 104 or to allow a portion of head (e.g., second extension member 528) to extend into body portion 104.

[0119] The head 500 may also include a support member 530 configured to be disposed within an inner bore 521 of the base member 502. The support member 530 is movable relative to the base member 502 such that it moves when the movable portion 504 is actuated. A biasing member (e.g., a spring or polymer sleeve) may be disposed between the base plate 522 and the support member 530 within the inner bore 521 of the base member 502 to bias the support member 530 (and thus the movable portion 504) into an extended position.

[0120] The support member 530 may include a base portion 532, an extension member 534 extending from the base portion 532, and a central cavity or hole 536 extending through the support member 530. The extension member 534 may include an externally threaded portion 538 configured to engage with the internally threaded portion 540 of the adjusting member 508. Figure 21The extension member 534 may also include one or more resilient clamping or latching members 542 disposed within the cutout 544. Each latching member 542 may be configured to engage the ridge portion 548 of the adjustment member 508. Figure 20 The latch 542 can be radially outwardly biased such that a protrusion 546 extending from the latch is pushed to engage with the ridge portion 548. This engagement of the latch 542 with the ridge portion 548 advantageously prevents accidental rotation of the adjusting member 508 relative to the support member 530, thus preventing accidental adjustment of the needle depth. For example, the latch 542 can be configured to limit rotation of the adjusting member 508 relative to the support member 530 unless a rotational force exceeding a selected threshold (e.g., greater than the biasing force of the latch 542) is applied to the adjusting member.

[0121] The support member 530 may also include a second extension member or rod 528, which is coupled to the sidewall of the base portion 532 and extends in the opposite direction to the first extension member 534. The second extension member 528 may be configured to engage a sensor (e.g., a light interruptor) disposed in the body portion 104 of the handheld device 100 to automatically trigger the injection of medication. For example, when the movable portion 504 is actuated, it moves the support member 530 such that the second extension member 528 engages the sensor. Once engaged, the sensor can trigger the injection of a predetermined dose of medication.

[0122] refer to Figures 20 to 21 As described above, the head 500 may include an adjustment member 508 coupled to the support member 530. The adjustment member 508 may include a body 550 configured as a generally cylindrical member defining an inner bore 552. The body 550 may have a first end 554 with a first inner diameter and a second end 556 with a second inner diameter smaller than the first inner diameter. The first end 554 and the second end 556 may be separated by a shoulder 558 within the inner bore 552. The second end 556 may include one or more protrusions 560 extending radially into the inner bore 552 and axially spaced from the distal edge 562 of the adjustment member 508. The second end may also include one or more clamping members 564, each clamping member having a radially extending lip portion 566 axially spaced from the protrusion 560. The clamping members 564 may be separated from the protrusion 560 by one or more channels 561 extending axially from the distal edge 562 of the adjustment member 508. The protrusion 560 and the clamping member 564 may be configured to engage the annular lip / shoulder 568 disposed on the first or proximal portion 570 of the movable portion 504. Figure 22 This allows the movable part 504 to be releasably coupled to the adjuster 508. (See reference) Figure 22The first or proximal edge 572 of the shoulder 568 may engage the protrusion 560, and the second or distal edge 574 of the shoulder may engage the clamping member 564. The clamping member 564 may be resilient, such that when the movable portion 504 is moved distally with sufficient force, the clamping member may bend or deform radially outward. This configuration advantageously allows the user to remove the movable portion 504 (e.g., replace the movable portion 504 or the needle 510) without removing or otherwise adjusting the position of the adjusting member 508, thereby preventing or mitigating unintentional adjustments to the needle insertion depth. For example, the user may pull the movable portion 504 to remove it from the adjusting member 508 without affecting the position of the adjusting member 508.

[0123] The adjusting member 508 can be used to adjust the insertion depth of the needle 510. The user can rotate the adjusting member 508 to increase or decrease the distance between the support member 530 and the movable portion 504. For example, by increasing the outer shoulder 576 of the support member 530 (… Figure 19 The distance between the outer shoulder 576 and the proximal edge 578 of the adjusting member 508 is adjusted to control the retractable distance of the movable portion 504. A greater distance between the outer shoulder 576 and the proximal edge 578 results in a shallower needle insertion depth. A smaller distance between the outer shoulder 576 and the proximal edge 578 results in a deeper needle insertion depth. As previously described, the latch 542 of the support member 530 engages the inner ridge portion 548 of the adjusting member 508, requiring the user to overcome the biasing force of the latch 542 to rotate the adjusting member relative to the support member 530, thereby preventing unintentional rotation of the adjusting member.

[0124] The outer surface of the adjustment member 508 may include a gripping portion configured to allow a user to more easily grip and manipulate the adjustment member 508. The gripping portion may include, for example, a plurality of ridges 580 and channels 582. In other embodiments, the gripping portion may include raised areas, knurling, or other textures to facilitate user gripping.

[0125] refer to Figure 14 As previously described, the head 500 may include a movable portion 504 that is telescopically movable relative to the base member 502 (as indicated by arrow 584). The movable portion 504 may be in an extended position (e.g., see...). Figure 14 ) and retraction position (e.g., see Figure 26The needle 510 moves between the extended and retracted positions. In the extended position, the distal point of the needle 510 is covered by the movable portion 504, and in the retracted position, the distal point of the needle 510 is exposed. As previously described, in some embodiments, for safety reasons, the head 500 may also include a biasing member (e.g., a spring, a compressible sleeve, etc.) configured to bias the movable portion to the extended position. The needle support 516 / needle interface 514 and thus the needle 510 can be coupled to the base member 502 (or, in some embodiments, to the body portion 104) such that the movable portion 504 is movable relative to the needle 510.

[0126] Pushing the movable portion 504 rearward (e.g., proximally) relative to the base member 502 exposes the distal point of the needle 510 and allows insertion into the subject. In some embodiments, pushing the movable portion 504 rearward into a retracted position (e.g., by pressing the movable portion 504 against a selected injection site on the subject) triggers the release of a predetermined dose of medication (e.g., by opening a valve associated with the needle and / or by triggering movement of a pump within the control unit 200). Further details of the movable portion and base member can be found, for example, in International Application PCT / IB2020 / 053177.

[0127] like Figure 22 As shown, the movable portion 504 may have a first or proximal end 570 and a second or distal end 586. The diameter of the first end 570 may be larger than the diameter of the first end, such that the movable portion 504 has a stepped configuration. The first end 570 may include opposing first and second holes 588 extending through the wall of the first end 570. The holes 588 may have an elongated, generally rectangular shape, configured to allow an extension member 592 of the safety cap 506 to extend through the holes 588, such that the movable portion 504 is movable relative to the safety cap 506 to expose the distal end of the needle 510.

[0128] refer to Figure 23 The safety cover 506 may include a base portion 590 (e.g., an annular base portion) and one or more extension members 592 extending from the base portion 590. The extension members 592 may be configured to extend beyond the distal end 594 of the movable portion 504 when the movable portion is in the extended position, such as... Figure 14 As shown in the illustrated embodiment, the safety cap 506 includes two extension members; however, in other embodiments, the cap 506 may include any number of extension members. The safety cap 506 may be coupled to the fixed portion 502 such that forces applied to the safety cap 506 do not cause the movable portion 504 to retract. The safety cap 506 may be configured to prevent or mitigate accidental injection by preventing actuation of the movable portion 504, unless the subject is at a selected injection site (e.g., between the extension members 592).

[0129] exist Figures 14 to 26 In the illustrated embodiment, the extension member 592 is an elongated rectangular member with a curved C-shaped cross-section. However, in other embodiments, the extension member 592 may have any of a variety of other shapes, such as an elongated member with a sine curve, a triangular member, a square member, etc. For example, Figure 27 An embodiment of a safety cap 506 for a larger subject is shown. In such an embodiment, the extension member 592 may have a sinusoidal S-shaped shape. Each extension member 592 may include a flared end portion 594 extending radially away from the longitudinal axis of the head 500 (e.g., an axis extending along the length of the needle 510). The flared end portion 594 facilitates the insertion of the subject between the extension members 592.

[0130] Each extension member 592 may include a lip portion 596 extending toward the central longitudinal axis of the head 500. The proximal edge 598 of the needle interface 516 ( Figure 16 The lip portion 596 can be engaged to further restrict movement of the needle 510 relative to the base member 502. The head 500 may also include an additional base member or clamp 600. Figure 16 The proximal edge 602 of the safety cover 506 may abut the base member or clamp. The clamp 600 may be disposed within the inner bore 521 of the base member 502 surrounding the connecting tube 512. In some embodiments, such as Figure 16 As shown, O-ring 604 ( Figure 16 It can be positioned between the clamp 600 and the safety cover 506 to help secure the components to each other.

[0131] refer to Figure 25 In some embodiments, the head 500 may also include a removal member 606. The removal member 606 may be configured to remove contaminants, such as dust or scale, adhering to the needle 510. Figure 25 In the illustrated embodiment, the removal member 606 may be an annular member including a pinhole 610 extending through the thickness of the member 606. Figure 24 As shown, the removal member 606 can be configured (e.g., sized and shaped) to fit into the distal hole 612 of the movable portion 504. Figure 22 Inside. The pinhole 610 may have a diameter slightly wider than the outer diameter of the needle 510, such that when the needle 510 retracts through the pinhole 152, the inner surface of the pinhole 152 contacts the outer surface of the needle 110 to remove contaminants or debris (e.g., dust, scale, etc.) from the surface of the needle 110.

[0132] In some specific embodiments, needle 510 may be an 18-gauge needle. In other embodiments, needle 510 may be between 20 and 23 gauge.

[0133] The injection device including the head 500 can be used in the following exemplary manner. An operator or user can position a subject (e.g., a fish) between the extension members 592 to align the subject with the distal end 594 of the movable portion 504 (and thus with the distal point of the needle 510). The user can push the subject against the movable portion 504, causing the movable portion 504 to move to a retracted position (see [link to original text]). Figure 26 The control unit automatically actuates the pump to inject a dose of medication into the subject at a selected injection site. Once the needle 510 has reached the selected insertion depth (determined by the interaction between the second extension member 528 and the sensor), the medication can be injected manually into the subject. In other embodiments, the medication can be injected manually (e.g., by pressing a trigger or other actuation mechanism to actuate the pump). The user can then release / remove the subject from between the extension members, allowing the movable portion 504 to be biased to the extended position and allowing the removal member 606 to remove any contaminants or debris from the surface of the needle. For fish subjects, the selected injection site may be, for example, the abdomen between the lateral fins. In some specific embodiments, the subject may be a fish up to 125 grams in size. In other embodiments, the subject may be a fish up to 2000 grams or larger.

[0134] Given the many feasible embodiments to which the principles of this disclosure can be applied, it should be recognized that the illustrated embodiments are merely preferred examples and should not be considered as limiting the scope. Rather, the scope is defined by the following claims. Therefore, we claim all that is within the scope and spirit of these claims.

Claims

1. An injection device, comprising: A handheld unit having a head and a main body, the head including a needle, a support portion and a movable portion, the movable portion being axially movable relative to the support portion between an extended position and a retracted position, in the retracted position, the distal point of the needle being exposed; as well as A safety cover, removably coupled to the movable portion, the safety cover including a base member and a locking plate pivotally coupled to the base member, the locking plate being pivotable between a locked position and an unlocked position, in which axial movement of the safety cover and the movable portion is restricted relative to the needle, and in which axial movement of the safety cover and the movable portion is permitted relative to the needle is permitted in the unlocked position.

2. The injection device according to claim 1, wherein, The safety cap also includes a first clamping member and a second clamping member, which extend from the base member and are configured such that positioning a subject between the first clamping member and the second clamping member aligns a selected injection site on the subject with the distal point of the needle.

3. The injection device according to claim 2, wherein, The first clamping member and the second clamping member are movable between an open position and a gripping position, in which the clamping member is configured to grip the subject.

4. The injection device according to claim 1, wherein, The safety cover also includes a biasing member configured to bias the locking plate to the locking position.

5. The injection device according to claim 1, wherein, The injection device further includes a needle support portion configured to releasably connect the needle to the body portion, wherein the locking plate includes a locking member extending from the locking plate and having a locking surface configured to engage a corresponding locking surface on the needle support portion when the locking plate is in the locked position.

6. The injection device according to claim 1, wherein, The safety cover includes an annular protrusion having a threaded outer surface configured to engage with a corresponding threaded surface of a connector, which is connected to the movable portion.

7. The injection device according to claim 1, wherein, The locking plate includes a hole extending through the thickness of the locking plate, the hole being aligned with the needle such that when the movable portion is in the retracted position, at least a portion of the needle extends through the hole.

8. The injection device according to claim 7, wherein, The injection device further includes a removal member disposed within the orifice, the removal member including a pinhole extending through the thickness of the removal member, the pinhole being sized such that the inner surface of the removal member contacts the outer surface of the needle to remove contaminants from the outer surface of the needle.

9. The injection device according to claim 1, wherein, The injection device also includes at least one control unit, which includes a pump and is located remotely from the handheld unit and fluidly connected to the handheld unit via one or more connecting tubes.

10. The injection device according to claim 9, wherein, The control unit is configured to be worn by the user.

11. The injection device according to claim 1, wherein, The handheld unit is configured to be submerged in water.

12. The injection device according to claim 1, wherein, The movable part also includes a locking mechanism that can move between a locked position and an unlocked position, wherein in the locked position the movable part is restricted from moving to the retracted position, and in the unlocked position the movable part can move between the extended position and the retracted position.

13. The injection device according to claim 12, wherein, The locking mechanism is configured to be actuated by a trigger coupled to the main body portion.

14. The injection device according to claim 1, wherein, The injection device is configured to operate in at least automatic mode, manual mode and semi-automatic mode and switch between them.

15. The injection device according to claim 14, wherein, When the injection device is in automatic mode, the drug is automatically administered when the needle is inserted into the subject's body at a selected depth.

16. The injection device according to claim 14, wherein, When the injection device is in manual mode, the drug is administered when a trigger connected to the main body is actuated.

17. An injection device, comprising: A base station includes a substrate, an upper member coupled to the substrate, and a head removably coupled to the upper member. The head includes a needle, a support portion, and a movable portion, the movable portion being axially movable relative to the support portion between an extended position and a retracted position, in which a distal point of the needle is exposed. as well as A safety cover, removably coupled to the upper member, the safety cover including a base member and a locking plate pivotally coupled to the base member, the locking plate being pivotable between a locked position and an unlocked position, in which the safety cover and the movable portion are restricted from axial movement relative to the needle, and in which the safety cover and the movable portion are axially movable relative to the needle in the unlocked position.

18. The injection device according to claim 17, wherein, The injection device further includes at least one control unit located remotely from the base station and fluidly connected to the upper component via one or more connecting pipes, the at least one control unit including a pump.

19. The injection device according to claim 18, wherein, The upper component is configured to communicate with the at least one control unit via a communication cable.

20. The injection device according to claim 17, wherein, The base station and the security cover are immersable in water.

21. The injection device according to claim 17, wherein, The safety cover also includes a biasing member configured to bias the locking plate to the locking position.

22. The injection device according to claim 17, wherein, The injection device further includes a needle support portion configured to releasably connect the needle to the upper member, wherein the locking plate includes a locking member extending from the locking plate and having a locking surface configured to engage a corresponding locking surface on the needle support portion when the locking plate is in the locked position.

23. The injection device according to claim 17, wherein, The safety cap also includes a first clamping member and a second clamping member, the first clamping member and the second clamping member extending from the base member and configured such that positioning a subject between the first clamping member and the second clamping member aligns a selected implantation site on the subject with the distal point of the needle.

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