Droplet size adjustable droplet generation device based on dual rectangular channel capillary

Abstract

The application discloses a droplet preparation device based on double-rectangular-channel capillary, which is adjustable in droplet size, and comprises a droplet generation device, a continuous phase fluid injection pump, a rotating device, a displacement device and a dispersed phase fluid injection pump; the droplet generation device comprises a cross-channel, a hollow protective sleeve I, a hollow protective sleeve II, a rectangular-channel capillary I, a rectangular-channel capillary II and a hollow protective sleeve III; the dispersed phase fluid flows in through the rectangular-channel capillary I, the continuous phase fluid flows in through the channel of the cross-channel I which is arranged perpendicularly to the hollow protective sleeve I, and the dispersed phase fluid is broken in the hollow protective sleeve II under the shearing action of the continuous phase fluid to generate droplets. The application changes the relative cross-sectional area size of the two rectangular-channel capillaries through the rotating device, changes the axial distance size between the two rectangular-channel capillaries through the displacement device, changes the flow rate and viscosity parameters of the two phases, and realizes the change of the droplet size within a certain range.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of microfluidics and medicine, new materials, environment, and particularly relates to a droplet preparation device with adjustable droplet size based on double-rectangular-channel capillary. BACKGROUND

[0002] The droplet preparation device based on glass capillary has the advantages of three-position coaxial, regionalized surface treatment, low cost, etc., and is widely used in the fields of chemical synthesis, biological analysis, drug preparation, etc. However, the droplet preparation device based on glass capillary needs to melt and stretch the capillary to obtain a small-size conical nozzle, and needs to align and bond the capillary multiple times under a microscope, etc. The manufacturing process is complex and time-consuming, and special instruments such as a capillary stretching instrument are required, which has many limitations.

[0003] The step emulsion droplet preparation device made of single-rectangular capillary has the advantages of simple device manufacturing, no need for additional equipment such as a capillary stretching instrument, etc. However, the droplet size prepared by the step emulsion method is almost not affected by the flow rate, so once the device is manufactured, the droplet size is difficult to adjust and cannot adapt to production.

[0004] Therefore, a capillary droplet preparation device with simple manufacturing, low cost and adjustable droplet size still needs to be developed. SUMMARY

[0005] In view of the problems existing in the prior art, the present application provides a droplet preparation device with adjustable droplet size based on double-rectangular-channel capillary.

[0006] The present application adopts the following technical scheme:

[0007] The droplet preparation device with adjustable droplet size based on double-rectangular-channel capillary comprises a droplet generation device, a continuous phase fluid injection pump, a rotating device, a displacement device, and a dispersed phase fluid injection pump.

[0008] The droplet generation device comprises a cross-channel one, a hollow protective sleeve one, a hollow protective sleeve two, a rectangular-channel capillary one, a rectangular-channel capillary two, and a hollow protective sleeve three.

[0009] The cross-channel one is a hollow channel with four sealed interfaces. The hollow protective sleeve one, the hollow protective sleeve two, and the hollow protective sleeve three all have hollow channels inside. The hollow protective sleeve one is fixedly connected to one interface of the cross-channel one and communicates with the interface, and the interface serves as an inlet end of the cross-channel one. One end of the hollow protective sleeve two is fixedly connected to an interface of the cross-channel one opposite to the inlet end and communicates with the interface, and the other end of the hollow protective sleeve two is fixedly connected to one end of the hollow protective sleeve three and communicates with the end.

[0010] The rectangular channel capillary one is located in the cross channel one, one end of the rectangular channel capillary one is fixedly connected to one end of the hollow protective sleeve one and communicated with the same, the other end of the rectangular channel capillary one is fixedly connected to one end of the hollow protective sleeve two and communicated with the same; the rectangular channel capillary two is located in the hollow protective sleeve three, one end of the rectangular channel capillary two is fixedly connected to the other end of the hollow protective sleeve two and communicated with the same; the rectangular channel capillary one and the rectangular channel capillary two are spaced apart along the axial direction and the cross sections of the two are opposite; the hollow protective sleeve one, the hollow protective sleeve two, the rectangular channel capillary one, the rectangular channel capillary two and the hollow protective sleeve three are coaxially arranged;

[0011] The hollow protective sleeve one located at the inlet end of the cross channel one is connected with the discrete phase fluid injection pump through a fluid pipeline and inputs the discrete phase fluid; two interfaces of the cross channel one arranged perpendicularly to the inlet end are respectively connected with the continuous phase fluid one injection pump through a fluid pipeline and input the continuous phase fluid;

[0012] The rotating device and the displacement device are connected with the hollow protective sleeve one, the rotating device drives the hollow protective sleeve one to rotate, and the displacement device drives the hollow protective sleeve one to move along the axial direction.

[0013] Further, the droplet generation device further comprises: a cross channel two, a continuous phase fluid two injection pump;

[0014] The cross channel two has the same structure as the cross channel one, one end of the hollow protective sleeve two is fixedly connected to the interface of the cross channel one opposite to the inlet end and communicated with the same, the other end of the hollow protective sleeve two is fixedly connected to one interface of the cross channel two and communicated with the same, and the interface is referred to as the inlet of the cross channel two; one end of the hollow protective sleeve three is fixedly connected to the interface of the cross channel two opposite to the inlet and communicated with the same;

[0015] The rectangular channel capillary two is located in the cross channel two, one end of the rectangular channel capillary two is fixedly connected to the hollow protective sleeve two and communicated with the same, the other end of the rectangular channel capillary two is fixedly connected to the hollow protective sleeve three and communicated with the same; the rectangular channel capillary one and the rectangular channel capillary two are spaced apart along the axial direction and the cross sections of the two are opposite; the hollow protective sleeve one, the hollow protective sleeve two, the rectangular channel capillary one, the rectangular channel capillary two and the hollow protective sleeve three are coaxially arranged;

[0016] Two interfaces of the cross channel two not arranged perpendicularly to the inlet are respectively connected with the continuous phase fluid two injection pump through a fluid pipeline.

[0017] Further, the rotating device comprises a motor, a gear, and a metal rotating shaft; the metal rotating shaft is hollow, is inserted into the inlet end of the cross passage one, is sleeved on the outside of the hollow protective sleeve one to form an interference connection; one gear of the gear pair is sleeved on the metal rotating shaft, and the gear shaft of the other gear is connected with the motor; the motor drives the gear shaft connected therewith to rotate; and due to the meshing effect of the gear pair, the gear sleeved on the metal rotating shaft drives the metal rotating shaft to rotate.

[0018] Further, the displacement device comprises a guide rail and a sliding block; the sliding block is fixedly connected with the metal rotating shaft; the sliding block is installed on the guide rail and moves axially on the guide rail to drive the metal rotating shaft to move axially.

[0019] Further, the end face, at which the hollow protective sleeve one is fixedly connected with the rectangular passage capillary one, the end face, at which the hollow protective sleeve two is fixedly connected with the rectangular passage capillary two, and the end face, at which the hollow protective sleeve two is fixedly connected with the hollow protective sleeve three, are all fixedly connected and sealed by UV ultraviolet glue.

[0020] Further, the end face, at which the hollow protective sleeve one is fixedly connected with the rectangular passage capillary one, and the end face, at which the rectangular passage capillary two is fixedly connected with the hollow protective sleeve three, are all fixedly connected and sealed by UV ultraviolet glue.

[0021] Further, the rectangular passage capillary two is subjected to hydrophobic treatment.

[0022] The beneficial effects of the present application are as follows:

[0023] (1) The present application changes the relative cross-sectional area of the rectangular passage capillary one and the rectangular passage capillary two by the rotating device, realizes the adjustment of the droplet size, changes the axial spacing between the rectangular passage capillary one and the rectangular passage capillary two by the displacement device, realizes the adjustment of the droplet size, and changes the two-phase flow and viscosity parameters by the continuous phase fluid one injection pump and / or the continuous phase fluid two injection pump, so that the droplet size is changed within a certain range, thereby solving the problem that the droplet size generated by the step emulsification method is difficult to change.

[0024] (2) The present application is based on a rectangular passage glass capillary, and the melting stretching and coaxial alignment of the capillary are not needed, so that the manufacturing of the glass capillary droplet generation device is greatly simplified. BRIEF DESCRIPTION OF DRAWINGS

[0025] Figure 1 It is a rectangular passage-based microdroplet generation device.

[0026] Figure 2 It is a double emulsion generation device with double rectangular passages.

[0027] Figure 3 Schematic diagram of droplet generation principle of rectangular channel.

[0028] Figure 4 Schematic diagram of collected droplets and analysis of Example 1, wherein (a) is a schematic diagram of droplets at the outlet of the device in Example 1; (b) is a schematic diagram of collected droplets in Example 1; (c) is a schematic diagram of collected droplets in Example 1; (d) is a schematic diagram of collected droplets in Example 1. Figure 4 (b) is a matlab droplet analysis diagram of (b); (d) is a schematic diagram of collected droplet size in Example 1.

[0029] Figure 5 Schematic diagram of droplet size change with rotation angle in Example 1.

[0030] In the figure, the droplet generation device 1, the cross channel one 2, the hollow protective sleeve one 3, the hollow protective sleeve two 4, the rectangular channel capillary one 5, the rectangular channel capillary two 6, the hollow protective sleeve three 7, the continuous phase fluid one injection pump 8, the rotating device 9, the motor 10, the gear pair 11, the metal rotating shaft 12, the displacement device 13, the dispersed phase fluid injection pump 14, the cross channel two 15, the continuous phase fluid two injection pump 16. DETAILED DESCRIPTION

[0031] The purpose and effect of the present application will become more apparent from the following detailed description of the preferred embodiments in conjunction with the accompanying drawings and examples. It should be understood that the specific embodiments described herein are merely intended to explain the present application and are not intended to limit the present application.

[0032] As shown in the figure, a droplet preparation device with adjustable droplet size based on double rectangular channel capillary, comprising: a droplet generation device 1, a continuous phase fluid one injection pump 8, a rotating device 9, a displacement device 13, a dispersed phase fluid injection pump 14. Figure 1 The droplet generation device 1 comprises: a cross channel one 2, a hollow protective sleeve one 3, a hollow protective sleeve two 4, a rectangular channel capillary one 5, a rectangular channel capillary two 6, a hollow protective sleeve three 7.

[0033] The cross channel one 2 is a hollow channel sealed at four interfaces, the four interfaces are circular tubes, and the hollow protective sleeve one 3, the hollow protective sleeve two 4, and the hollow protective sleeve three 7 all have hollow channels inside. The hollow protective sleeve one 3 is inserted into one interface of the cross channel one 2, which serves as the inlet end of the cross channel one 2; one end of the hollow protective sleeve two 4 is inserted into the interface opposite the inlet end of the cross channel one 2, and the other end of the hollow protective sleeve two 4 is inserted into the hollow protective sleeve three 7.

[0034]

[0035] ​The rectangular channel capillary 5 is located in the cross channel 2, one end of the rectangular channel capillary 5 is inserted into one end of the hollow protective sleeve 3, the other end of the rectangular channel capillary 5 is inserted into one end of the hollow protective sleeve 4; the rectangular channel capillary 6 is located inside the hollow protective sleeve 7, the end of the rectangular channel capillary 6 extending out of the hollow protective sleeve 7 is inserted into the other end of the hollow protective sleeve 4; the rectangular channel capillary 5 and the rectangular channel capillary 6 are spaced apart along the axial direction and the cross sections of the two are opposite. The hollow protective sleeve 3, the hollow protective sleeve 4, the rectangular channel capillary 5, the rectangular channel capillary 6 and the hollow protective sleeve 7 are coaxially arranged.

[0036] The end surface of the hollow protective sleeve 3 inserted by the rectangular channel capillary 5, the end surface of the hollow protective sleeve 4 inserted by the rectangular channel capillary 6 and the end surface of the hollow protective sleeve 7 inserted by the hollow protective sleeve 4 are fixed and sealed by using UV ultraviolet glue.

[0037] The hollow protective sleeve 3 at the inlet end of the cross channel 2 is connected with the dispersed phase fluid injection pump 14 through a fluid pipeline and is connected with the dispersed phase fluid; the two interfaces of the cross channel 2 arranged perpendicularly to the inlet end are respectively connected with the continuous phase fluid injection pump 8 through a fluid pipeline and are connected with the continuous phase fluid.

[0038] The rotating device 9 and the displacement device 13 are connected with the hollow protective sleeve 3, the rotating device 9 drives the hollow protective sleeve 3 to rotate, and the displacement device 13 drives the hollow protective sleeve 3 to move along the axial direction.

[0039] As shown in the drawings, Figure 1 In this embodiment, the rotating device 9 includes a motor 10, a gear pair 11 and a metal rotating shaft 12. The metal rotating shaft 12 is hollow, the metal rotating shaft 12 is inserted into the inlet end of the cross channel 2 and is sleeved outside the hollow protective sleeve 3 to form an interference connection. One gear of the gear pair 11 is sleeved on the metal rotating shaft 12, the gear shaft of the other gear is connected with the motor 10, the motor 10 drives the gear to rotate, and the gear sleeved on the metal rotating shaft 12 drives the metal rotating shaft 12 to rotate due to the meshing effect of the gear pair 11.

[0040] The displacement device 13 includes a guide rail and a sliding block. The sliding block is fixedly connected with the metal rotating shaft 12, the sliding block is installed on the guide rail and can move axially on the guide rail, thereby driving the metal rotating shaft 12 to move axially.

[0041] Discrete phase fluid injection pump 14 introduces discrete phase fluid into hollow protective sleeve 3 through fluid pipeline. The discrete phase fluid enters the main channel (i.e., hollow protective sleeve 4) through rectangular channel capillary tube 5. Continuous phase fluid injection pump 8 introduces continuous phase fluid into cross channel 2 through fluid pipeline. The continuous phase fluid flows into hollow protective sleeve 4 along the gap between hollow protective sleeve 4 and rectangular channel capillary tube 5. The two-phase interface is stabilized at hollow protective sleeve 4.

[0042] like Figure 3 As shown, the discrete phase fluid exhibits Rayleigh-Taylor instability under the combined action of continuous shearing by the continuous phase fluid and the surface tension of both phases. This instability further generates droplets that enter the rectangular channel capillary tube 6 and the hollow protective sleeve 7. The generated droplets are collected in a petri dish, and their size and distribution are observed under a microscope. The droplet size is calculated and statistically analyzed using a MATLAB program.

[0043] like Figure 2 As shown, in Figure 1 Based on this, the hollow protective sleeve 3 7 is moved down, and a cross channel 2 15 is added between the hollow protective sleeve 3 7 and the cross channel 1 2. The cross channel 2 15 is a hollow channel with four sealed ports. One end of the hollow protective sleeve 2 4 is inserted into the interface opposite to the inlet end of the cross channel 1 2, and the other end of the hollow protective sleeve 2 4 is inserted into one interface of the cross channel 2 15, which is denoted as the inlet of the cross channel 2 15. The hollow protective sleeve 3 7 is inserted into the interface opposite to the inlet of the cross channel 2 15. The rectangular channel capillary tube 2 6 is located inside the cross channel 2 15. One end of the rectangular channel capillary tube 2 6 is inserted into the hollow protective sleeve 2 4, and the other end is inserted into the hollow protective sleeve 3 7. The rectangular channel capillary tubes 1 5 and 2 6 are spaced a certain distance apart along the axial direction, and their cross sections are opposite each other. The hollow protective sleeves 1 3, 2 4, 1 5, 2 6, and 3 7 are arranged coaxially.

[0044] It is important to note that, with Figure 1 The difference in connection method is that the end face of the hollow protective sleeve 2 4 into which the rectangular channel capillary tube 2 6 is inserted is not sealed, while the end face of the hollow protective sleeve 3 7 into which the rectangular channel capillary tube 2 6 is inserted is fixed and sealed with UV adhesive.

[0045] The two connectors of the cross channel 2 15, which are arranged perpendicularly to the inlet of the cross channel 2 15, are respectively connected to the continuous phase fluid injection pump 16 via fluid pipelines, and a different continuous phase fluid is introduced into it, which is different from the continuous phase fluid introduced into the continuous phase fluid injection pump 8. The other structures remain unchanged.

[0046] A discrete phase fluid injection pump 14 connected to the hollow sheath 1 through a fluid line injects a discrete phase fluid into the rectangular channel capillary 1 5; a continuous phase fluid 1 injection pump 8 connected to the cross channel 1 2 through a fluid line injects a continuous phase fluid into the hollow sheath 2 4 along the gap between the hollow sheath 2 4 and the rectangular channel capillary 1 5; a continuous phase fluid 2 injection pump 16 connected to the cross channel 2 1 5 through a fluid line injects another continuous phase fluid into the hollow sheath 2 4 along the gap between the hollow sheath 2 4 and the rectangular channel capillary 1 5 in the opposite direction, and the three-phase fluid is sheared and broken at the gap between the two rectangular channel capillaries to generate a double emulsion. The generated double emulsion enters the rectangular channel capillary 1 6 and the hollow sheath 3 7, and the generated droplets are collected in a culture dish. The size and distribution range of the droplets are observed under a microscope, and the size of the droplets is calculated and counted using a matlab program.

[0047] The present application changes the size of the droplets within a certain range by changing the relative cross-sectional area of the rectangular channel capillary 1 5 and the rectangular channel capillary 2 6 using the rotating device 9, changing the axial spacing between the rectangular channel capillary 1 5 and the rectangular channel capillary 2 6 using the displacement device 1 3, and changing the flow rate and viscosity parameters of the two phases using the continuous phase fluid 1 injection pump 8 and / or the continuous phase fluid 2 injection pump 1 6.

[0048] The following are several specific embodiments of the present application.

[0049] Embodiment 1 :

[0050] Based on the droplet size adjustable droplet preparation device based on double rectangular channel capillary as shown in Figure 1 The rectangular channel capillary 1 5 has a channel cross-sectional size of 0.05 mm*0.5 mm, the discrete phase fluid is water, the continuous phase fluid is dimethyl silicone oil with a viscosity of 1 0 cs, and the rectangular channel capillary 2 6 is hydrophobic. The droplet generation device is verified.

[0051] The discrete phase fluid injection pump 1 4 injects a discrete phase fluid into the hollow sheath 1 through a fluid line, and the discrete phase fluid enters the hollow sheath 2 4 through the rectangular channel capillary 1 5; the continuous phase fluid 1 injection pump 8 injects a continuous phase fluid into the cross channel 1 2 through a fluid line, and the continuous phase fluid flows into the hollow sheath 2 4 along the gap between the hollow sheath 2 4 and the rectangular channel capillary 1 5. At this time, the discrete phase fluid generates droplets under the continuous shearing action of the continuous phase fluid, and the droplets enter the rectangular channel capillary 1 6 and the hollow sheath 3 7. The schematic diagram of the droplets at the outlet of the device is shown in Figure 4 (a). The generated droplets are collected in a culture dish, and the size and distribution range of the droplets are observed under a microscope. The collected droplets observed are shown in Figure 4(b) shown; the droplet size is calculated by using the matlab program, and the droplet analysis diagram obtained is as shown in Figure 4 (c), and the collected droplet size statistical diagram is as shown in Figure 4 (d).

[0052] The rectangular channel capillary one 5 and the rectangular channel capillary two 6 are arranged to be in contact, and the rotation angle is 90°, the dispersed phase fluid flow is set to 90ul / h, the continuous phase fluid flow is set to 9ul / h, the generated droplet size is counted, the droplet size is measured by using the area of the generated diagram in the channel, and Table 1 is the size of five generated droplets and the average size.

[0053] Table 1 Droplet cross-sectional size

[0054] Drop number 1 2 3 4 5 Average Cross-sectional area (pm 2 )]]> 27735 28430 28718 32164 30913 29592

[0055] The droplet preparation method provided by the application realizes the rotation of the metal channel 12 through the rotating device 9, and then changes the relative area size of the rectangular channel capillary one 5 and the rectangular channel capillary two 6, that is, changes the channel size of the dispersed phase fluid entering the rectangular channel 6. When the relative cross-sectional area of the rectangular channel changes, the shear action of the dispersed phase fluid changes, and the size of the generated droplet changes. When the rotation angle changes from 0° to 90°, the relative area gradually becomes smaller, the shear action becomes weaker, and the droplet size becomes larger. The following experiments are used to prove it:

[0056] Under the condition that other conditions remain unchanged, the relative rotation angle of the rectangular channel capillary one 5 and the rectangular channel capillary two 6 is changed, and the angles are set to 30°, 45°, 60°, 75° and 90° respectively. The contact cross-sectional area of the rectangular channel capillary one 5 and the rectangular channel capillary two 6 corresponding to different rotation angles is shown in Table 2. The droplet size generated under different rotation angles is shown in Table 3. According to the data in Table 3, the curve of the droplet size changing with the relative rotation angle is as shown in Figure 5 .

[0057] Table 2 Rectangular channel contact cross-sectional area

[0058]

[0059] Table 3 Droplet size under different rotation angles

[0060]

[0061] The embodiment does not set the case that the rectangular channel capillary one 5 and the rectangular channel capillary two 6 are in contact and the rotation angle is 0°, because the two-phase fluid shearing action cannot generate droplets at this time. When the rectangular channel capillary one 5 and the rectangular channel capillary two 6 are in contact, only a certain angle is rotated to make the channel sections of the rectangular channel capillary one 5 and the rectangular channel capillary two 6 not completely opposite, so that the droplets can be generated. However, if the rectangular channel capillary one 5 and the rectangular channel capillary two 6 are axially spaced apart by a certain distance, the two-phase fluid shearing action can generate droplets at any rotation angle.

[0062] Embodiment 2:

[0063] The droplet preparation method provided by the application can also change the size of the droplets by adjusting the distance between the two rectangular channels,

[0064] The axial distance between the two rectangular channels is changed by the displacement device 13. Within a certain range, when the axial distance between the two rectangular channels is changed, the shearing action of the external phase on the dispersed phase fluid changes, and the size of the generated droplets changes. When the distance is larger, the shearing action is weaker, and the size of the droplets is larger. The following experiments are used to prove this.

[0065] A double rectangular channel structure is used, the channel section size is 0.05mm*0.5mm, water is used as the dispersed phase fluid, 10cs viscosity dimethyl silicone oil is used as the continuous phase fluid, and the rectangular channel capillary two 6 is hydrophobic. The dispersed phase fluid flow is set to 90μl / h, the continuous phase fluid flow is set to 90μl / h, and the rotation angle of the two rectangular channels is set to 90°. In the case that other conditions remain unchanged, the distance between the two rectangular channels is changed, and is set to 0mm and 0.025mm respectively. The size of the droplets generated at different distances is measured, and the size statistics are shown in Table 4.

[0066] Table 4 Droplet section area changes with the distance between the two rectangular channels

[0067]

[0068] Those skilled in the art can understand that the above description is only a preferred example of the application and is not used to limit the application, although the application has been described in detail with reference to the foregoing examples, and those skilled in the art can still modify the technical solutions recorded in the foregoing examples or make equivalent replacements for part of the technical features. Any modification, equivalent replacement, etc. made within the spirit and principles of the application shall be included in the protection scope of the application.

Claims

1. A droplet size-adjustable droplet generation device based on a double-rectangular channel capillary, characterized by, The application relates to a liquid droplet generating device. The liquid droplet generating device (1) comprises a cross channel (2), a hollow protective sleeve (3), a hollow protective sleeve (4), a rectangular channel capillary (5), a rectangular channel capillary (6) and a hollow protective sleeve (7). The cross channel (2) is a hollow channel with four sealed interfaces, the hollow protective sleeve (3), the hollow protective sleeve (4) and the hollow protective sleeve (7) all have hollow channels, the hollow protective sleeve (3) is fixedly connected to one interface of the cross channel (2) and communicates with the interface, the interface is used as an inlet end of the cross channel (2), one end of the hollow protective sleeve (4) is fixedly connected to an interface of the cross channel (2) opposite to the inlet end and communicates with the interface, and the other end of the hollow protective sleeve (4) is fixedly connected to one end of the hollow protective sleeve (7) and communicates with the end. The rectangular channel capillary (5) is located in the cross channel (2), one end of the rectangular channel capillary (5) is fixedly connected to one end of the hollow protective sleeve (3) and communicates with the end, the other end of the rectangular channel capillary (5) is fixedly connected to one end of the hollow protective sleeve (4) and communicates with the end, the rectangular channel capillary (6) is located in the hollow protective sleeve (7), one end of the rectangular channel capillary (6) is fixedly connected to the other end of the hollow protective sleeve (4) and communicates with the end, the rectangular channel capillary (5) and the rectangular channel capillary (6) are axially spaced apart by a certain distance and have opposite cross sections, and the hollow protective sleeve (3), the hollow protective sleeve (4), the rectangular channel capillary (5), the rectangular channel capillary (6) and the hollow protective sleeve (7) are coaxially arranged. The hollow protective sleeve (3) located at the inlet end of the cross channel (2) is connected with the discrete phase fluid injection pump (14) through a fluid pipeline and is used for inputting discrete phase fluid, two interfaces of the cross channel (2) arranged perpendicularly to the inlet end are respectively connected with the continuous phase fluid injection pump (8) through fluid pipelines and are used for inputting continuous phase fluid. The rotating device (9) and the displacement device (13) are connected with the hollow protective sleeve (3), the rotating device (9) drives the hollow protective sleeve (3) to rotate, and the displacement device (13) drives the hollow protective sleeve (3) to move along the axial direction. The liquid droplet generating device (1) further comprises a cross channel (15) and a continuous phase fluid injection pump (16).

2. The droplet size adjustable droplet generation device based on dual rectangular channel capillaries of claim 1, wherein, ​ The cross passage two (15) structure is same with the cross passage one (2), one end of the hollow protective sleeve two (4) is fixedly connected with and communicated with the interface of the cross passage one (2) opposite to the inlet end, the other end of the hollow protective sleeve two (4) is fixedly connected with and communicated with one interface of the cross passage two (15), and the interface is called the inlet of the cross passage two (15); one end of the hollow protective sleeve three (7) is fixedly connected with and communicated with the interface of the cross passage two (15) opposite to the inlet; The rectangular passage capillary two (6) is located in the cross passage two (15), one end of the rectangular passage capillary two (6) is fixedly connected with and communicated with the hollow protective sleeve two (4), and the other end of the rectangular passage capillary two (6) is fixedly connected with and communicated with the hollow protective sleeve three (7); the rectangular passage capillary one (5) and the rectangular passage capillary two (6) are spaced apart along the axial direction, and the cross sections of the two are opposite; the hollow protective sleeve one (3), the hollow protective sleeve two (4), the rectangular passage capillary one (5), the rectangular passage capillary two (6) and the hollow protective sleeve three (7) are coaxially arranged; Two interfaces of the cross passage two (15) which are not vertically arranged with the inlet are connected with the continuous phase fluid two injection pump (16) through fluid lines.

3. The droplet size adjustable droplet generation device based on double rectangular channel capillaries of claim 1 or claim 2, wherein, The rotating device (9) comprises a motor (10), a gear pair (11) and a metal rotating shaft (12); the metal rotating shaft (12) is hollow, is inserted into the inlet end of the cross passage one (2) and is sleeved on the outside of the hollow protective sleeve one (3) to form an interference connection; one gear of the gear pair (11) is sleeved on the metal rotating shaft (12), and the gear shaft of the other gear is connected with the motor (10); the motor (10) drives the gear shaft connected therewith to rotate, and the gear sleeved on the metal rotating shaft (12) drives the metal rotating shaft (12) to rotate due to the meshing of the gear pair (11).

4. The droplet size adjustable droplet generation device based on dual rectangular channel capillaries of claim 3, wherein, The displacement device (13) comprises a guide rail and a sliding block; the sliding block is fixedly connected with the metal rotating shaft (12), is installed on the guide rail and moves axially on the guide rail to drive the metal rotating shaft (12) to move axially.

5. The droplet size adjustable droplet generation device based on dual rectangular channel capillaries of claim 1, wherein, The end faces, at which the hollow protective sleeve one (3) and the rectangular passage capillary one (5) are fixedly connected, the end faces, at which the hollow protective sleeve two (4) and the rectangular passage capillary two (6) are fixedly connected and the end faces, at which the hollow protective sleeve two (4) and the hollow protective sleeve three (7) are fixedly connected are all fixedly connected and sealed by UV ultraviolet glue.

6. The droplet size adjustable droplet generation device based on dual rectangular channel capillaries of claim 2, wherein, The end faces, at which the hollow protective sleeve one (3) and the rectangular passage capillary one (5) are fixedly connected and the end faces, at which the rectangular passage capillary two (6) and the hollow protective sleeve three (7) are fixedly connected are all fixedly connected and sealed by UV ultraviolet glue.

7. The droplet size adjustable droplet generation device based on double rectangular channel capillaries of claim 1 or claim 2, wherein, The rectangular passage capillary two (6) is subjected to hydrophobic treatment.

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