A polyurethane sponge, a method for preparing the same and an application thereof

Abstract

The application provides a medical polyurethane cotton ball and a preparation method and application thereof, and the medical polyurethane cotton ball is prepared by cutting polyurethane sponge, and the polyurethane sponge is prepared by foaming polyether triols, toluene diisocyanate, water, a crosslinking agent and an auxiliary agent. The medical polyurethane cotton ball has the advantages of simple preparation method, no biological toxicity, fast liquid instantaneous suction speed, large liquid absorption amount, high liquid extrusion rate, no debris or cotton wool after smearing, certain elasticity, easy preservation and the like. The polyurethane cotton ball can be directly used in a dry state, can quickly absorb a large amount of wound exudate, reduces operation time and the use amount of the cotton ball; can be used after absorbing iodophor or medical alcohol, can complete large-area smearing operation at one time, reduces the replacement frequency of the cotton ball, and improves smearing efficiency. The medical polyurethane cotton ball is soft and comfortable to the skin in dry and wet states, effectively reduces the stimulation to the skin and the wound.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of medical materials, and particularly relates to a polyurethane sponge and a preparation method and application thereof, in particular to a medical polyurethane cotton ball and a preparation method and application thereof. BACKGROUND

[0002] The medical cotton ball is a common medical supply and is divided into a sterile supplied medical cotton ball and a non-sterile supplied medical cotton ball. The sterile supplied medical cotton ball is widely applied to nursing, examination, surgery and daily disinfection in medical institutions.

[0003] At present, the medical cotton ball is prepared from the sterilized absorbent cotton and has the problems of easy insect breeding, metamorphic property, inconvenient long-term storage, poor liquid absorption performance, low liquid extrusion rate, increased operation time and use amount of the absorbent cotton ball during the debridement, small medicine absorption amount of the alcohol or iodophor absorbent cotton ball, reduced smearing efficiency, increased replacement frequency of the absorbent cotton ball and medicine liquid use amount. In addition, the absorbent cotton ball has no resilience, is inconvenient for the doctor to use and has poor patient experience as a temporary filling material for oral examination and repair. Meanwhile, the absorbent cotton ball has not enough skin softness, and the absorbent cotton ball is easy to be left during use, which causes poor comfort and easy irritation of the wound during the treatment of the wound. SUMMARY

[0004] Therefore, the application aims to provide a polyurethane sponge and a preparation method and application thereof. The polyurethane sponge has good performance, such as simple preparation method, no biological toxicity, fast liquid instantaneous absorption speed, large liquid absorption amount, high liquid extrusion rate, no debris or cotton wool during smearing, certain resilience, skin softness, comfort and the like.

[0005] The application provides a polyurethane sponge prepared from materials including a polyether triol, toluene diisocyanate, water, a crosslinking agent and an auxiliary agent.

[0006] Preferably, the polyether triol is prepared from materials including ethylene oxide and propylene oxide.

[0007] Preferably, the number average molecular weight of the polyether triol is 3000-6000.

[0008] Preferably, the auxiliary agent is selected from one or more of an open pore agent, an emulsifying agent and a uniform foaming agent.

[0009] The application provides a preparation method of the polyurethane sponge.

[0010] reacting the polyether triol and toluene diisocyanate to obtain an oligomer;

[0011] mixing water, a crosslinking agent and an auxiliary agent to obtain a mixture;

[0012] mixing and pouring the oligomer and the mixture to obtain a polyurethane sponge.

[0013] Preferably, the mass ratio of the polyether triol and toluene diisocyanate is 100:(20-40);

[0014] The mass ratio of the water, the crosslinking agent and the auxiliary agent is 100:(14-50):(15-40);

[0015] The mass ratio of the oligomer and the mixture is 1:(0.9-1.4).

[0016] Preferably, the auxiliary agent is selected from an emulsifier, a cell opener and a foam stabilizer;

[0017] The mass ratio of the emulsifier, the cell opener and the foam stabilizer is 100:(110-490):(44-110).

[0018] Preferably, after pouring, the method further comprises:

[0019] The obtained pouring product is subjected to heat treatment and sterilization treatment.

[0020] Preferably, the temperature of the heat treatment is 37-120℃, and the time is 0.5-24h;

[0021] The sterilization treatment adopts ethylene oxide and / or radiation.

[0022] The present application provides a medical polyurethane cotton ball prepared from the material of the polyurethane sponge as described in the above technical solution.

[0023] The medical polyurethane cotton ball provided by the present application has the advantages of simple preparation method, no biological toxicity, fast liquid instantaneous suction speed, large liquid absorption amount, high liquid extrusion rate, no debris or cotton wool after smearing, certain elasticity, easy preservation and no insect, skin-friendly softness and high comfort.

[0024] The dry medical polyurethane cotton ball provided by the application can quickly absorb a large amount of liquid at one time, reduces the operation time and the use amount of the cotton ball; the dry medical polyurethane cotton ball has liquid absorption and expansion, and can be seamlessly filled when used as a temporary filler. The alcohol or iodophor medical polyurethane cotton ball can absorb a large amount of liquid medicine, and can complete the smearing operation of a large area at one time, thereby improving the smearing efficiency and reducing the replacement frequency of the cotton ball and the waste of the liquid medicine. The medical polyurethane cotton ball provided by the application is soft and comfortable in the dry and wet states, effectively reduces the irritation to the skin and the wound, and can be applied to various nursing, examination, operation and daily disinfection. BRIEF DESCRIPTION OF DRAWINGS

[0025] Figure 1 A sample picture of the medical polyurethane cotton ball prepared in Example 1 of the application;

[0026] Figure 2 A sample picture of the medical polyurethane cotton ball prepared in Example 2 of the application;

[0027] Figure 3 A sample picture of the medical polyurethane cotton ball prepared in Example 3 of the application;

[0028] Figure 4 A sample picture of the medical polyurethane cotton ball prepared in Example 4 of the application;

[0029] Figure 5 A sample picture of the medical polyurethane cotton ball prepared in Example 5 of the application;

[0030] Figure 6 A sample picture of the medical polyurethane cotton ball prepared in Example 6 of the application;

[0031] Figure 7 Comparison of the resilience of the products prepared in Example 1 and Comparative Example 1 of the application;

[0032] Figure 8 Comparison of the use of the products prepared in Example 1 and Comparative Example 1 of the application. DETAILED DESCRIPTION

[0033] The technical solutions in the embodiments of the application will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the application, rather than all the embodiments of the application. Based on the embodiments in the application, all the other embodiments obtained by a person of ordinary skill in the art without creative labor fall within the protection scope of the application.

[0034] The application provides a polyurethane sponge prepared from materials including a polyether triol, toluene diisocyanate, water, a crosslinking agent and an auxiliary agent.

[0035] In the present application, the polyether triol is preferably polymerized from ethylene oxide and propylene oxide; the number average molecular weight of the polyether triol is preferably 3000-6000, more preferably 4000-5000. The present application does not have special restrictions on the source of the polyether triol, which can be obtained by market purchase.

[0036] In the present application, the toluene diisocyanate preferably includes:

[0037] 2,4-toluene diisocyanate and 2,6-toluene diisocyanate.

[0038] In the present application, the mass content of 2,4-toluene diisocyanate in toluene diisocyanate is preferably 65-100%, more preferably 80-100%; the mass content of 2,6-toluene diisocyanate in toluene diisocyanate is preferably 0-35%, more preferably 0-20%.

[0039] In the present application, the crosslinking agent is preferably selected from one or more of small molecule diols and small molecule triols; the small molecule diol is preferably selected from one or more of ethylene glycol, 1,4-butanediol, 1,3-butanediol, and neopentyl glycol; the small molecule triol is preferably selected from one or more of trimethylolpropane, glycerol, low molecular weight polyether triol, and low molecular weight polycaprolactone triol; the molecular weight of the low molecular weight polyether triol is preferably 400-1000; the molecular weight of the low molecular weight polycaprolactone triol is preferably 400-1000.

[0040] In the present application, the auxiliary agent is preferably selected from one or more of cell opening agents, emulsifiers, and foam stabilizers.

[0041] In the present application, the cell opening agent is preferably selected from one or more of polybutadiene, polymeric siloxane, propylene oxide ethylene oxide propylene glycol ether, and polyoxyalkylene-polysiloxane copolymer.

[0042] In the present application, the emulsifier is preferably selected from one or more of polyoxyethylene and polyoxypropylene block polymers, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, aliphatic polyoxyethylene (15) ether, polyoxyethylene ether, and polyoxypropylene ether.

[0043] In the present application, the foam stabilizer is preferably selected from one or more of dimethyl silicone oil and polysilane-alkylene oxide block copolymer.

[0044] The present application provides a preparation method of the polyurethane sponge described in the above technical solution, comprising:

[0045] reacting the polyether triol and the toluene diisocyanate to obtain an oligomer;

[0046] mixing water, a crosslinking agent and an auxiliary agent to obtain a mixture;

[0047] casting the oligomer and the mixture to obtain a polyurethane sponge.

[0048] In the present application, the mass ratio of the polyether triol and toluene diisocyanate is preferably 100:(20-40), more preferably 100:(25-35).

[0049] In the present application, the reaction preferably obtains an oligomer with stable NCO value; the reaction process is preferably carried out under nitrogen protection, and the reaction temperature is preferably 60-100℃, more preferably 70-80℃.

[0050] In the present application, the mass ratio of the water, the crosslinking agent and the auxiliary agent is preferably 100:(14-50):(15-40), more preferably 100:(20-40):(20-30).

[0051] In the present application, the auxiliary agent is preferably selected from emulsifiers, open-cell agents and foam stabilizers; the mass ratio of the emulsifiers, open-cell agents and foam stabilizers is preferably 100:(110-490):(44-110), more preferably 100:(200-400):(50-100).

[0052] In the present application, the mixing is preferably uniform; the mixing process is preferably mechanical stirring, the temperature of the mechanical stirring is preferably 10-40℃, more preferably 20-30℃; the speed of the mechanical stirring is preferably 1500-4000rpm, more preferably 2000-3000rpm; the time of the mechanical stirring is preferably 10-48h, more preferably 24-36h.

[0053] In the present application, the mass ratio of the oligomer and the mixture is preferably 1:(0.9-1.4), more preferably 1:(1.0-1.3).

[0054] In the present application, the casting is preferably pouring into a mold by mechanical stirring or foaming into a mold in a foaming machine, more preferably foaming into a mold in a foaming machine; the temperature of the mechanical stirring is preferably 15-35℃, more preferably 20-30℃; the speed of the mechanical stirring is preferably 1000-2000rpm, more preferably 1300-1700rpm, most preferably 1500rpm; the time of the mechanical stirring is preferably 10-20s, more preferably 13-17s, most preferably 15s, and free foaming is carried out by mechanical stirring; the temperature of the foaming in the foaming machine is preferably 25-45℃, more preferably 35-40℃.

[0055] In the present application, the casting preferably further comprises:

[0056] The cast product is subjected to heat treatment and sterilization treatment.

[0057] In the present application, the temperature of the heat treatment is preferably 37-120℃, more preferably 70-100℃, and most preferably 80-90℃; the time of the heat treatment is preferably 0.5-24h, more preferably 1-20h, more preferably 2-10h, and most preferably 2-4h.

[0058] In the present application, the sterilization treatment is preferably ethylene oxide sterilization and / or radiation sterilization, and more preferably ethylene oxide sterilization.

[0059] The present application provides a medical polyurethane cotton ball prepared from the material comprising the polyurethane sponge as described in the above technical solution.

[0060] In the present application, the medical polyurethane cotton ball can be cut from the polyurethane sponge.

[0061] In the present application, the medical polyurethane cotton ball can be in different shapes for different application scenarios, such as a spherical body which can be used as a liquid absorbing body for wiping operation; a small cylinder which can be used in the nasal cavity of adults and children for nasal bleeding or rhinorrhea; a sheet which can be used for absorbing blood and tissue fluid from a wound.

[0062] In the present application, the medical polyurethane cotton ball has a certain expansion rate and can be used as a temporary filler in the examination process.

[0063] The medical polyurethane cotton ball provided by the present application can be applied in various nursing, examination, surgery and daily disinfection.

[0064] The present application provides a medical polyurethane cotton ball, a preparation method and application thereof. The medical polyurethane cotton ball is prepared by a simple method, has no biological toxicity, has a fast liquid instantaneous absorption speed, a large liquid absorption amount, a high liquid extrusion rate, does not shed debris or cotton when being applied, has a certain elasticity, is easy to store and does not breed insects, is skin-friendly and soft, and has high comfort. In the present application, the dry medical polyurethane cotton ball can quickly absorb a large amount of liquid at one time, thereby reducing the operation time and the amount of cotton ball used. The dry medical polyurethane cotton ball has liquid absorption and expansion properties, and can be seamlessly filled when used as a temporary filler. The alcohol or iodophor medical polyurethane cotton ball can absorb a large amount of liquid and complete a large-area application operation at one time, thereby improving the application efficiency and reducing the replacement frequency of the cotton ball and the waste of the liquid. The medical polyurethane cotton ball provided by the present application is skin-friendly and soft in both dry and wet states, has high comfort, effectively reduces the irritation to the skin and a wound, and can be applied in various nursing, examination, surgery and daily disinfection.

[0065] Example 1

[0066] Under nitrogen protection, 20.19 g of toluene diisocyanate (a mixture of 80% by mass of 2,4-toluene diisocyanate and 20% by mass of 2,6-toluene diisocyanate) was added to 100.00 g of anhydrous polyether triol (ethylene oxide:propylene oxide is 30:70, number average molecular weight is 6000, polyol of model 6001 from Dow Chemical Company, USA), and the mixture was stirred at 70 °C until the NCO value was stable to obtain polyurethane cotton ball A material;

[0067] 100.00 g of deionized water, 0.50 g of trimethylolpropane, 33.87 g of glycerol, 13.92 g of polysiloxane (Y-10366), 7.16 g of aliphatic polyoxyethylene (15) ether and 4.78 g of sorbitan fatty acid ester were mixed evenly at 15 °C to obtain polyurethane cotton ball B material;

[0068] 50.00 g of the above A material and 56.00 g of B material were mechanically stirred and freely foamed at 20 °C, the rotation speed was 1500 rpm, and the time was 15 s. After foaming, medical polyurethane cotton ball material was obtained;

[0069] The formed medical polyurethane cotton ball material was taken out of the mold, placed in an oven at 60 °C for heat treatment for 4 h, sterilized with ethylene oxide, and placed in a sterile environment for 14 days before performance testing.

[0070] The product prepared in Example 1 was cut into spheres with a mass of 0.5 g (as Figure 1 shown) for absorbing blood and tissue fluid exuded from the wound.

[0071] Example 2

[0072] Under nitrogen protection, 32.30 g of toluene diisocyanate (100% by mass of 2,4-toluene diisocyanate) was added to 100.00 g of anhydrous polyether triol (ethylene oxide:propylene oxide is 40:60, number average molecular weight is 5000, polyol of model 4701 from Dow Chemical Company, USA), and the mixture was stirred at 80 °C until the NCO value was stable to obtain polyurethane cotton ball A material;

[0073] 100.00 g of deionized water, 1.20 g of 1,3-butanediol, 42.46 g of glycerol, 10.22 g of polyether triol, 9.23 g of polyoxyethylene ether and 5.12 g of polyoxyethylene sorbitan fatty acid ester were mixed evenly at 30 °C to obtain polyurethane cotton ball B material;

[0074] 50.00 g of the above A material and 66.50 g of B material were mechanically stirred and freely foamed at 35 °C, the rotation speed was 1200 rpm, and the time was 15 s. After foaming, medical polyurethane cotton ball material was obtained;

[0075] The shaped medical polyurethane cotton ball material was taken out from the mold, placed in a 70°C oven for heat treatment for 3.5h, then sterilized by ethylene oxide, and placed in a sterile environment for 14 days before performance testing.

[0076] The product prepared in Example 2 was cut into a sphere with a mass of 0.5g (as shown in Figure 2 The product prepared in Example 2 was cut into a sphere with a mass of 0.5g (as shown in

[0077] Example 3

[0078] Under nitrogen protection, 39.83g of toluene diisocyanate (a mixture of 80% mass percentage of 2,4-toluene diisocyanate and 20% mass percentage of 2,6-toluene diisocyanate) was added to 100.00g of anhydrous polyether triol (a mixture of ethylene oxide and propylene oxide at a ratio of 50:50, with a number average molecular weight of 4000, polyol model 3553 from Bayer, Germany), and the reaction was stirred at 90°C until the NCO value was stable, to obtain polyurethane cotton ball A material;

[0079] 100.00g of deionized water, 13.58g of glycerol, 20.96g of propylene oxide ethylene propylene glycol ether, 8.47g of aliphatic polyoxyethylene (15) ether, 1.65g of sorbitan fatty acid ester, 1.65g of polyoxyethylene sorbitan fatty acid ester, 2.57g of polyoxyethylene and polyoxypropylene block polymer, and 3.85g of polycaprolactone triol were uniformly mixed at 25°C to obtain polyurethane cotton ball B material;

[0080] 50.00g of the above A material and 76.90g of the B material were foamed in a foaming machine at 40°C, and after foaming, a medical polyurethane cotton ball material was obtained;

[0081] The shaped medical polyurethane cotton ball material was taken out from the mold, placed in a 70°C oven for heat treatment for 3.5h, then sterilized by ethylene oxide, and placed in a sterile environment for 14 days before performance testing.

[0082] The product prepared in Example 3 was cut into a cylinder with a length of 2.0cm and a diameter of 0.5cm (as shown in Figure 3 The product prepared in Example 3 was cut into a cylinder with a length of 2.0cm and a diameter of 0.5cm (as shown in

[0083] Example 4

[0084] Under nitrogen protection, 100.00 g of anhydrous polyether triol (epoxy ethane:epoxy propane is 60:40, the number average molecular weight is 5000, EP-330N type polyol of Shandong Lanshengdong Chemical Co., Ltd.) is added with 24.37 g of toluene diisocyanate (a mixture of 65% mass percentage of 2,4-toluene diisocyanate and 35% mass percentage of 2,6-toluene diisocyanate), and stirred to react at 100°C until the NCO value is stable to obtain polyurethane cotton ball A material;

[0085] 100.00 g of deionized water, 9.23 g of glycerol, 25.34 g of propylene oxide ethylene propylene glycol ether, 6.69 g of aliphatic polyoxyethylene (15) ether, 4.65 g of sorbitan fatty acid ester, 2.57 g of polyoxyethylene and polyoxypropylene block polymer, 6.93 g of polycaprolactone triol and 0.19 g of color paste are mixed uniformly at 40°C to obtain polyurethane cotton ball B material;

[0086] 50.00 g of the above A material and 62.50 g of the B material are foamed by a foaming machine at 30°C, and after foaming, a medical polyurethane cotton ball material is obtained;

[0087] The shaped medical polyurethane cotton ball material is taken out of the mold, placed in an oven at 85°C for heat treatment for 2.5 h, sterilized by ethylene oxide, and placed in a sterile environment for 14 days before performance testing.

[0088] The product prepared in Example 4 is cut into a sheet-shaped rectangular cuboid with a length of 12.0 cm, a width of 8.0 cm, and a height of 0.5 cm (as shown in Figure 4 ), which is used to absorb blood and tissue fluid exuded from a larger area wound.

[0089] Example 5

[0090] Under nitrogen protection, 100.00 g of anhydrous polyether triol (epoxy ethane:epoxy propane is 70:30, the number average molecular weight is 3000, 3033LM type polyol of American Dow) is added with 35.81 g of toluene diisocyanate (a mixture of 80% mass percentage of 2,4-toluene diisocyanate and 20% mass percentage of 2,6-toluene diisocyanate), and stirred to react at 75°C until the NCO value is stable to obtain polyurethane cotton ball A material;

[0091] 100.00 g of deionized water, 3.05 g of glycerol, 18.53 g of polymeric siloxane, 7.88 g of polyoxyethylene ether, 6.30 g of sorbitan fatty acid ester and 11.21 g of polycaprolactone triol are mixed uniformly at 20°C to obtain polyurethane cotton ball B material;

[0092] 50g of the above-mentioned material A and 70.00g of material B are foamed in a foaming machine at 25°C to obtain medical polyurethane cotton ball material.

[0093] The molded medical polyurethane cotton ball material was removed from the mold, placed in a 90℃ oven for 2 hours for heat treatment, sterilized with ethylene oxide, and placed in a sterile environment for 14 days before performance testing.

[0094] The product prepared in Example 5 was cut into sheet-like cylinders with a diameter of 10.0 cm and a height of 0.5 cm (e.g., Figure 5 As shown), it is used as an absorbent for the drug solution (75% medical alcohol and 0.2% iodine tincture) for large-area application, skin disinfection, wiping, medical device disinfection, and lubrication.

[0095] Example 6

[0096] Under nitrogen protection, 28.09g of toluene diisocyanate (a mixture of 80% by weight of 2,4-toluene diisocyanate and 20% by weight of 2,6-toluene diisocyanate) was added to 100.00g of anhydrous polyether triol (ethylene oxide: propylene oxide ratio of 30:70, number average molecular weight of 5000, EP-3600 model polyol from Shandong Lanxing Dongda Chemical Co., Ltd.). The mixture was stirred at 85°C until the NCO value stabilized, and polyurethane cotton ball material A was obtained.

[0097] 100.00g of deionized water, 19.85g of glycerol, 22.48g of propylene oxide ethylene oxide propylene glycol ether, 10.03g of polyoxyethylene ether, 3.30g of dehydrated sorbitan fatty acid ester and 1.15g of polyoxyethylene dehydrated sorbitan fatty acid ester were mixed evenly at 35°C to obtain polyurethane cotton ball material B.

[0098] 50.00g of the above-mentioned material A and 72.00g of material B are foamed in a foaming machine at 45℃ to obtain medical polyurethane cotton ball material.

[0099] The molded medical polyurethane cotton ball material was removed from the mold, placed in a 100℃ oven for 2 hours for heat treatment, sterilized with ethylene oxide, and placed in a sterile environment for 14 days before performance testing.

[0100] The product prepared in Example 6 was cut into cylinders with a length of 2.0 to 5.0 cm and a diameter of 0.7 cm (e.g., ...). Figure 6 (As shown), it is a temporary filling material used during oral examinations and repairs.

[0101] Comparative Example 1

[0102] Commercially available medical absorbent cotton balls (Zhejiang Shaoxing Medical Device Registration No. 20170083 (Revised)).

[0103] The commercially available medical absorbent cotton ball is soaked in 75% alcohol and medical iodophor to reach the saturated state of liquid absorption.

[0104] Performance detection

[0105] The medical polyurethane cotton balls prepared in Examples 1-6 and the medical absorbent cotton ball of Comparative Example 1 are subjected to performance testing, and the liquid absorption performance is evaluated by absorption time, water absorption amount and liquid extrusion rate. The detection method is as follows: the absorption time refers to that 1 mL of room temperature water is quickly added on the horizontal surface of a sample with an area of 10 cm 2 or more by using a pipette gun, and the time for the water to be completely absorbed by the sample is recorded by a stopwatch; the complete absorption refers to that there is no liquid water in the visual field horizontal to the sample plane; the water absorption amount refers to that about 5 g of the sample is placed in a beaker which is large enough and contains enough water, and after being soaked for 15 min, the sample is taken out by using a test basket which has been weighed, and is hung for 30 s to control water, and then is placed in another beaker with a known mass, and is weighed, and the mass of water absorbed per gram of the sample is calculated; the liquid extrusion rate refers to that the sample after the water absorption amount is tested is squeezed dry by hand until no liquid drops, and then is placed in a test basket, and is weighed, and the percentage of the squeezed water in the total water absorbed by the sample is calculated; the smaller the absorption time, the better the hydrophilicity of the medical polyurethane cotton ball; the larger the water absorption amount, the stronger the liquid absorption performance of the medical polyurethane cotton ball; the larger the liquid extrusion rate, the smaller the liquid retention capacity of the medical polyurethane cotton ball; the cytotoxicity is evaluated according to the national standard GB / T 16886.5-2003, and the smaller the value, the safer and more reliable the medical polyurethane cotton ball is.

[0106] The detection results are as follows:

[0107]

[0108]

[0109] It can be seen that the liquid absorption time, liquid absorption amount, liquid extrusion rate and volume expansion rate of the polyurethane cotton ball prepared in the examples are equal to or better than those of the commercially available medical absorbent cotton ball of Comparative Example 1, and the polyurethane cotton ball has no biological toxicity. At the same time, the polyurethane cotton ball in the examples has a certain resilience (as shown in Figure 7 , wherein a-c are the pictures of the product prepared in Example 1, and d-f are the pictures of the product of Comparative Example 1, and the polyurethane cotton ball is pressed and rebounded), and does not fall off or shed during the application process (as shown in Figure 8 , wherein a is the original picture, b is the picture after the medical polyurethane cotton ball prepared in Example 1 is wiped, and there is no cotton residue, and c is the picture after the medical absorbent cotton ball of Comparative Example 1 is wiped, and there is cotton residue, in order to facilitate observation, the cotton balls are dyed and dried before use), and is soft and comfortable. In addition, the preparation method of the polyurethane cotton ball prepared in the examples is simple, easy to store and does not breed insects.

[0110] The application provides a medical polyurethane cotton ball and a preparation method and application thereof. The medical polyurethane cotton ball has the advantages of simple preparation method, no biological toxicity, fast liquid instantaneous suction speed, large liquid absorption amount, high liquid extrusion rate, no dust or cotton fiber after smearing, certain elasticity, easy preservation, no insect, skin-friendly softness and high comfort. In the application, the dry medical polyurethane cotton ball can quickly absorb a large amount of liquid at one time, thereby reducing the operation time and the use amount of the cotton ball; the dry medical polyurethane cotton ball has liquid absorption swelling property, and can be used as a temporary filler to realize seamless filling. The alcohol or iodophor medical polyurethane cotton ball can absorb a large amount of liquid, and can complete the smearing operation of a large area at one time, thereby improving the smearing efficiency and reducing the replacement frequency of the cotton ball and the waste of the liquid. The medical polyurethane cotton ball provided by the application is skin-friendly soft and comfortable in the dry and wet states, can effectively reduce the stimulation to the skin and the wound, and can be applied to various nursing, examination, surgery and daily disinfection.

[0111] While the application has been described and illustrated with reference to specific embodiments thereof, these descriptions and illustrations are not intended to limit the application. Those skilled in the art can readily devise various changes and modifications of the embodiments without departing from the true spirit and scope of the application as defined by the appended claims. All such modifications are intended to be within the scope of the claims. Although the method disclosed herein has been described with reference to particular operations performed in a particular order, it will be understood that these operations can be combined, sub-divided, or re-ordered to form equivalent methods without departing from the teachings of the present application. Accordingly, unless specifically indicated herein, the order and grouping of operations are not a limitation of the present application.

Claims

1. A method for preparing a polyurethane sponge, comprising: reacting a polyether triol and toluene diisocyanate to obtain an oligomer; the polyether triol is prepared from a material comprising ethylene oxide and propylene oxide; the number average molecular weight of the polyether triol is 3000-6000; and the mass ratio of the polyether triol to toluene diisocyanate is 100:(20-40); mixing water, a crosslinking agent and an auxiliary agent to obtain a mixture; the auxiliary agent is selected from one or more of a cell opener, an emulsifier and a foam stabilizer; the mass ratio of the water, the crosslinking agent and the auxiliary agent is 100:(14-50):(15-40); the crosslinking agent is selected from one or more of a small molecule diol and a small molecule triol; the small molecule diol is selected from one or more of ethylene glycol, 1,4-butanediol, 1,3-butanediol and neopentyl glycol; the small molecule triol is selected from one or more of trimethylolpropane, glycerol, a low molecular weight polyether triol and a low molecular weight polycaprolactone triol; the molecular weight of the low molecular weight polyether triol is 400-1000; and the molecular weight of the low molecular weight polycaprolactone triol is 400-1000; mixing the oligomer and the mixture to obtain a cast product, and subjecting the cast product to heat treatment and sterilization treatment; the heat treatment is performed at a temperature of 37-120℃ for 0.5-24h to obtain a polyurethane sponge; and the mass ratio of the oligomer to the mixture is 1:(0.9-1.4).

2. The method of claim 1, wherein, the auxiliary agent is selected from a cell opener, an emulsifier and a foam stabilizer; and the mass ratio of the emulsifier, the cell opener and the foam stabilizer is 100:(110-490):(44-110).

3. The method of claim 1, wherein, the sterilization treatment is performed using ethylene oxide and / or radiation.

4. A medical polyurethane sponge ball comprising the polyurethane sponge obtained by the method of claim 1.

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