A disposable postoperative dressing plant concentrated film and preparation method thereof

Abstract

The invention provides a disposable postoperative dressing plant concentrated film and a preparation method thereof. The concentrated film comprises an extracted plant concentrated liquid and auxiliary materials, and also comprises a primer. The dressing plant concentrated film adopts the synergistic effect of the extracted plant concentrated liquid, the auxiliary materials and the primer, and the combined antibacterial effect is significantly enhanced, the irritation is small, and there is no toxic side effect, which promotes the rapid healing of wound surfaces and the restoration of skin barrier function, while avoiding the formation of severe scars on the wound surfaces.

Description

Technical Field

[0001] The invention relates to the technical field of medical dressings, and in particular to a disposable postoperative dressing plant concentrated film and a preparation method thereof. Background Art

[0002] The skin is the first line of defense to prevent the human body from being harmed by the external environment. It can maintain normal physiological functions such as temperature regulation, stimulation, absorption and excretion, and immune regulation. When the skin is damaged by mechanical and chemical stimulation from the external environment, it will not only cause physical and mental harm to people, but also bring economic burden and pressure to people. Wound healing is a complex process. After trauma, with the participation and interaction of cells and cytokines in the body, it undergoes a healing process of four dynamic repair stages: coagulation, inflammation, tissue proliferation, and remodeling. After the skin is traumatized, blood vessels rupture, and platelets form blood clots at the damaged site to fill the damaged area. At the same time, blood vessels contract to reduce bleeding and tissue fluid exudation, and enter the inflammation stage. Immune cells such as macrophages and neutrophils will be recruited at the wound under the mediation of signals. After clearing the cells and tissue fragments at the wound, they will release growth factors, stimulate and induce the growth and differentiation of fibroblasts and endothelial cells, and generate new granulation tissue. The new myofibroblasts pull the subcutaneous tissue to gradually migrate to the wound surface, generate new epidermis, and cover the wound. Modern medicine has conducted in-depth research on the process and mechanism of wound repair, as well as the cytokines that affect wound repair, and has a clearer theoretical basis and more treatment methods for wound repair.

[0003] Currently, most medical dressings have the functions of covering, protecting, absorbing water and moisturizing, and being breathable, and can meet the treatment needs of most wounds. However, different wound conditions have different requirements for dressings. Many dressings on the market currently have single performance, lack biological activity and complex therapeutic functions, and are difficult to meet the physiological needs of wound healing, and cause severe postoperative scar hyperplasia, and fail to achieve the effect of rapid wound healing and radical treatment of scars at the same time. Summary of the invention

[0004] In view of this, the present invention proposes a disposable postoperative dressing plant concentrated film and a preparation method thereof to solve the above problems.

[0005] The technical solution of the present invention is achieved as follows: a disposable postoperative dressing plant concentrated film: comprising an extracted plant concentrated solution and auxiliary materials, the extracted plant concentrated solution comprising the following raw materials in parts by weight: 1-2 parts of honeysuckle, 1-3 parts of wormwood, 1-1.5 parts of dandelion, 0.5-1.5 parts of safflower, 2-3 parts of gardenia, and 2-3 parts of aloe; the auxiliary materials comprise the following raw materials in parts by weight: 0.5-0.8 parts of camphor, 0.5-0.8 parts of menthol, 0.5-0.8 parts of borneol, and 0.2-0.3 parts of polyvinyl alcohol.

[0006] Furthermore, the extracted plant concentrate comprises the following raw materials in parts by weight: 1.8 parts of honeysuckle, 2 parts of wormwood, 1.2 parts of dandelion, 1 part of safflower, 2.5 parts of gardenia, and 2.5 parts of aloe.

[0007] Furthermore, the auxiliary materials include the following raw materials in parts by weight: 0.75 parts of camphor, 0.75 parts of menthol, 0.75 parts of borneol, and 0.25 parts of polyvinyl alcohol.

[0008] Furthermore, the postoperative dressing plant concentrated film also includes a raw material, which includes the following raw materials in parts by weight: 0.4-0.9 parts of shea butter, 0.6-1.2 parts of melaleuca oil, 0.3-0.8 parts of rapeseed polypeptide, 0.2-0.4 parts of seaweed active peptides, and 0.03-0.1 parts of p-anisic acid, and the molecular weight of the seaweed active peptides is 5000-1000Da.

[0009] Furthermore, the mass volume kg / L ratio of the auxiliary material, the raw material and the extracted plant concentrate is 20-30:8-15:100.

[0010] Furthermore, a method for preparing a disposable postoperative dressing plant concentrated film comprises the following steps:

[0011] S1, extracting plant concentrate: wash, remove impurities, dry, chop and dry the above honeysuckle, wormwood, dandelion, safflower, gardenia and aloe, grind to 100-120 mesh sieve to form mixed powder after drying, add deionized water, stir evenly, the mass volume ratio of mixed powder to deionized water is 1-3:80 g / mL, place in ultrasonic extractor, extract at power of 300-500W and temperature of 60-80°C for 5-7min, centrifuge, take out supernatant to obtain first concentrated solution, add deionized water to the residue, the mass volume ratio of residue to deionized water is 1-3:80 g / mL, repeat the above ultrasonic extraction method to obtain second concentrated solution;

[0012] S2. Preparation of liquid I: Mix the first concentrated solution and the second concentrated solution in a volume ratio of 6:3-5, add auxiliary materials, heat to 50-70° C. and stir for 10-30 min at a stirring rate of 400-600 rpm to obtain liquid I;

[0013] S3. Preparation of liquid II: slowly add the material into liquid I, stirring until the mixture is uniform, and then high-speed homogenize at 40-80°C to obtain liquid II.

[0014] S4. Use a coating machine to coat the above liquid I or liquid II on the non-woven fabric surface layer, with the coating layer thickness of 0.1-0.3 mm, and then cure it at room temperature in a clean room to obtain a disposable postoperative dressing plant concentrated film.

[0015] Furthermore, the high-speed homogenization condition rate of S3 is 8000-12000 rpm, and the homogenization time is 10-20 min.

[0016] Furthermore, disposable postoperative dressing plant concentrate film is used for non-chronic postoperative wound care.

[0017] Furthermore, non-chronic postoperative wound care is the suturing of incisions and covering of wound surfaces after surgical operations.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] The plant concentrated film of the postoperative dressing adopts the synergistic effect of the extracted plant concentrated liquid and the auxiliary materials and the auxiliary materials, the combined antibacterial effect is significantly enhanced, the irritation is small, the side effects are non-toxic, the wound surface is promoted to heal quickly, the skin barrier function is promoted to be restored, and the formation of severe scars on the wound surface is avoided; the raw materials in the plant concentrated liquid are extracted according to a specific ratio, which is beneficial to improving the repair ability of the concentrated film; the addition of the auxiliary materials is helpful to maintain normal immunity, can better assist the plant concentrated liquid to induce the immunity of the skin system and promote cell proliferation, accelerate cell repair, prevent tissue adhesion, and avoid secondary damage to the new skin; wherein shea butter and melaleuca oil form a stable hydrophobic structure, which is beneficial to reduce the abnormal permeability of blood vessels at the wound surface and alleviate the edema at the wound surface; rapeseed polypeptide and seaweed active peptide can regulate the synthesis of collagen at the wound surface, which is helpful for wound healing; the effective components precipitated from the concentrated film can destroy the scar cell wall, the effective components inhibit absorption, remove scar hyperplastic cells and fibrotic connective tissue, thereby achieving the purpose of radically curing the scar, making the scar wound surface equivalent to normal skin, and scar cells no longer continue to proliferate. DETAILED DESCRIPTION

[0020] In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

[0021] Unless otherwise specified, the experimental methods used in the embodiments of the present invention are all conventional methods.

[0022] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources.

[0023] Example 1

[0024] A disposable postoperative dressing plant concentrated film: comprising an extracted plant concentrated solution and auxiliary materials, wherein each 10L of the extracted plant concentrated solution comprises the following raw materials by weight: 1.8kg of honeysuckle, 2kg of wormwood, 1.2kg of dandelion, 1kg of safflower, 2.5kg of gardenia, 2.5kg of aloe, and the balance is deionized water; the auxiliary materials comprise the following raw materials by weight: 0.75kg of camphor, 0.75kg of menthol, 0.75kg of borneol, and 0.25kg of polyvinyl alcohol;

[0025] The preparation method of the above-mentioned concentration membrane comprises the following steps:

[0026] S1, extracting plant concentrate: wash, remove impurities, dry, chop and dry the above honeysuckle, wormwood, dandelion, safflower, gardenia and aloe, grind to 120 mesh sieve to form mixed powder after drying, add deionized water, stir evenly, the mass volume ratio of mixed powder to deionized water is 2:80 g / mL, place in ultrasonic extractor, extract at a power of 400 W and a temperature of 70°C for 6 min, centrifuge, take out the supernatant to obtain a first concentrated solution, add deionized water to the residue, the mass volume ratio of the residue to deionized water is 2:80 g / mL, repeat the above ultrasonic extraction method to obtain a second concentrated solution;

[0027] S2, preparation of liquid I: 6000 mL of the first concentrated solution and 4000 mL of the second concentrated solution were mixed evenly, 2.5 kg of auxiliary materials were added, and the mixture was heated to 60° C. and stirred for 20 min at a stirring rate of 500 rpm to obtain liquid I;

[0028] S3. Use a coating machine to coat the above-mentioned I liquid on the non-woven fabric surface layer, and the coating layer thickness is 0.1-0.3 mm. Then, cure it at room temperature in a clean room to obtain a disposable postoperative dressing plant concentrated film.

[0029] Example 2

[0030] A disposable postoperative dressing plant concentrated film comprises an extracted plant concentrated solution, auxiliary materials and a base material, wherein each 10L of the extracted plant concentrated solution comprises the following raw materials by weight: 1kg of honeysuckle, 1kg of wormwood, 1kg of dandelion, 0.5kg of safflower, 2kg of gardenia and 2kg of aloe; the auxiliary materials comprise the following raw materials by weight: 0.5kg of camphor, 0.5kg of menthol, 0.5kg of borneol and 0.2kg of polyvinyl alcohol; the base material comprises the following raw materials by weight: 0.4kg of shea butter, 0.6kg of melaleuca oil, 0.3kg of rapeseed polypeptide, 0.2kg of seaweed active peptide and 0.03kg of p-anisic acid, wherein the molecular weight of the seaweed active peptide is 5000-1000Da.

[0031] Example 3

[0032] A disposable postoperative dressing plant concentrated film comprises an extracted plant concentrated solution, auxiliary materials and a base material, wherein each 10L of the extracted plant concentrated solution comprises the following raw materials by weight: 2kg of honeysuckle, 3kg of wormwood, 1.5kg of dandelion, 1.5kg of safflower, 3kg of gardenia and 3kg of aloe; the auxiliary materials comprise the following raw materials by weight: 0.8kg of camphor, 0.8kg of menthol, 0.8kg of borneol and 0.3kg of polyvinyl alcohol; the base material comprises the following raw materials by weight: 0.9kg of shea butter, 1.2kg of melaleuca oil, 0.8kg of rapeseed polypeptide, 0.4kg of seaweed active peptide and 0.1kg of p-anisic acid, wherein the molecular weight of the seaweed active peptide is 5000-1000Da.

[0033] Example 4

[0034] A disposable postoperative dressing plant concentrated film: comprising an extracted plant concentrated solution, auxiliary materials and a base material, wherein the extracted plant concentrated solution comprises the following raw materials by weight per 10 liters: 1.8 kg of honeysuckle, 2 kg of wormwood, 1.2 kg of dandelion, 1 kg of safflower, 2.5 kg of gardenia, and 2.5 kg of aloe; the auxiliary materials comprise the following raw materials by weight: 0.75 kg of camphor, 0.75 kg of menthol, 0.75 kg of borneol, and 0.25 kg of polyvinyl alcohol; the base material comprises the following raw materials by weight: 0.6 kg of shea butter, 0.9 kg of melaleuca oil, 0.5 kg of rapeseed polypeptide, 0.3 kg of seaweed active peptide, and 0.06 kg of p-anisic acid, wherein the molecular weight of the seaweed active peptide is 5000-1000 Da;

[0035] The above-mentioned Examples 2-4 adopt the following preparation method:

[0036] S1, extracting plant concentrate: wash, remove impurities, dry, chop and dry the above honeysuckle, wormwood, dandelion, safflower, gardenia and aloe, grind to 110 mesh sieve to form mixed powder after drying, add deionized water, stir evenly, the mass volume ratio of mixed powder to deionized water is 2:80 g / mL, place in ultrasonic extractor, extract at power of 400 W and temperature of 70°C for 6 min, centrifuge and separate, take out supernatant to obtain first concentrated solution, add deionized water to the residue, the mass volume ratio of residue to deionized water is 2:80 g / mL, repeat the above ultrasonic extraction method to obtain second concentrated solution;

[0037] S2. Preparation of liquid I: Mix the first concentrated solution and the second concentrated solution in a volume ratio of 6:4, add auxiliary materials, heat to 60° C. and stir for 20 min at a stirring rate of 500 rpm to obtain liquid I;

[0038] S3. Preparation of liquid II: slowly add the material into liquid I, stirring until the mixture is uniformly mixed, and then high-speed homogenization is performed at 60° C. The high-speed homogenization condition rate is 10,000 rpm, and the homogenization time is 15 min to obtain liquid II.

[0039] S4. Use a coating machine to coat the above II liquid on the non-woven fabric surface layer, with a coating layer thickness of 0.2 mm, and then cure it at room temperature in a clean room to obtain a disposable postoperative dressing plant concentrated film.

[0040] Example 5

[0041] A disposable postoperative dressing plant concentrated film: comprising an extracted plant concentrated solution, auxiliary materials and a base material, wherein the extracted plant concentrated solution comprises the following raw materials by weight per 10 liters: 1.8 kg of honeysuckle, 2 kg of wormwood, 1.2 kg of dandelion, 1 kg of safflower, 2.5 kg of gardenia, and 2.5 kg of aloe; the auxiliary materials comprise the following raw materials by weight: 0.75 kg of camphor, 0.75 kg of menthol, 0.75 kg of borneol, and 0.25 kg of polyvinyl alcohol; the base material comprises the following raw materials by weight: 0.6 kg of shea butter, 0.9 kg of melaleuca oil, 0.5 kg of rapeseed polypeptide, 0.3 kg of seaweed active peptide, and 0.06 kg of p-anisic acid, wherein the molecular weight of the seaweed active peptide is 5000-1000 Da;

[0042] The above-mentioned concentrated membrane is prepared by the following method:

[0043] S1, extracting plant concentrate: wash, remove impurities, dry, chop and dry the above honeysuckle, wormwood, dandelion, safflower, gardenia and aloe, grind to 100 mesh sieve to form mixed powder after drying, add deionized water, stir evenly, the mass volume ratio of mixed powder to deionized water is 1:80 g / mL, place in ultrasonic extractor, extract at a power of 300 W and a temperature of 60°C for 5 min, centrifuge, take out the supernatant to obtain a first concentrated solution, add deionized water to the residue, the mass volume ratio of the residue to deionized water is 1:80 g / mL, repeat the above ultrasonic extraction method to obtain a second concentrated solution;

[0044] S2. Preparation of liquid I: Mix the first concentrated solution and the second concentrated solution in a volume ratio of 6:3, add auxiliary materials, heat to 50-70° C. and stir for 10 min at a stirring rate of 400 rpm to obtain liquid I;

[0045] S3. Preparation of liquid II: slowly add the material into liquid I, stirring until the mixture is uniformly mixed, and then high-speed homogenization is performed at 40° C. The high-speed homogenization condition speed is 8000 rpm and the homogenization time is 10 min to obtain liquid II.

[0046] S4. Use a coating machine to coat the above liquid I or liquid II on the non-woven fabric surface layer, with the coating layer thickness of 0.1-0.3 mm, and then cure it at room temperature in a clean room to obtain a disposable postoperative dressing plant concentrated film.

[0047] Example 6

[0048] A disposable postoperative dressing plant concentrated film: comprising an extracted plant concentrated solution, auxiliary materials and a base material, wherein the extracted plant concentrated solution comprises the following raw materials by weight per 10 liters: 1.8 kg of honeysuckle, 2 kg of wormwood, 1.2 kg of dandelion, 1 kg of safflower, 2.5 kg of gardenia, and 2.5 kg of aloe; the auxiliary materials comprise the following raw materials by weight: 0.75 kg of camphor, 0.75 kg of menthol, 0.75 kg of borneol, and 0.25 kg of polyvinyl alcohol; the base material comprises the following raw materials by weight: 0.6 kg of shea butter, 0.9 kg of melaleuca oil, 0.5 kg of rapeseed polypeptide, 0.3 kg of seaweed active peptide, and 0.06 kg of p-anisic acid, wherein the molecular weight of the seaweed active peptide is 5000-1000 Da;

[0049] The above-mentioned concentrated membrane is prepared by the following method:

[0050] S1, extracting plant concentrate: wash, remove impurities, dry, chop and dry the above honeysuckle, wormwood, dandelion, safflower, gardenia and aloe, grind to 120 mesh sieve to form mixed powder after drying, add deionized water, stir evenly, the mass volume ratio of mixed powder to deionized water is 3:80 g / mL, place in ultrasonic extractor, extract at a power of 500 W and a temperature of 80°C for 7 min, centrifuge, take out the supernatant to obtain a first concentrated solution, add deionized water to the residue, the mass volume ratio of the residue to deionized water is 3:80 g / mL, repeat the above ultrasonic extraction method to obtain a second concentrated solution;

[0051] S2. Preparation of liquid I: Mix the first concentrated solution and the second concentrated solution in a volume ratio of 6:5, add auxiliary materials, heat to 70° C. and stir for 30 min at a stirring rate of 600 rpm to obtain liquid I;

[0052] S3. Preparation of liquid II: slowly add the material into liquid I, stirring until the mixture is uniformly mixed, and then high-speed homogenization is performed at 80° C. The high-speed homogenization condition rate is 12000 rpm, and the homogenization time is 20 min to obtain liquid II.

[0053] S4. Use a coating machine to coat the above liquid I or liquid II on the non-woven fabric surface layer, with the coating layer thickness of 0.1-0.3 mm, and then cure it at room temperature in a clean room to obtain a disposable postoperative dressing plant concentrated film.

[0054] Comparative Example 1

[0055] The difference between this comparative example and Example 1 is that the extracted plant concentrate includes the following raw materials by weight per 10L: 3kg of honeysuckle, 1kg of wormwood, 2kg of dandelion, 0.1kg of safflower, 1kg of gardenia, and 5kg of aloe.

[0056] Specifically, it is a disposable postoperative dressing plant concentrated film: it includes an extracted plant concentrated solution and auxiliary materials, wherein each 10L of the extracted plant concentrated solution includes the following raw materials by weight: 3kg of honeysuckle, 1kg of wormwood, 2kg of dandelion, 0.1kg of safflower, 1kg of gardenia, 5kg of aloe, and the balance is deionized water; the auxiliary materials include the following raw materials by weight: 0.75kg of camphor, 0.75kg of menthol, 0.75kg of borneol, and 0.25kg of polyvinyl alcohol;

[0057] The preparation method of the above-mentioned concentration membrane comprises the following steps:

[0058] S1, extracting plant concentrate: wash, remove impurities, dry, chop and dry the above honeysuckle, wormwood, dandelion, safflower, gardenia and aloe, grind to 120 mesh sieve to form mixed powder after drying, add deionized water, stir evenly, the mass volume ratio of mixed powder to deionized water is 2:80 g / mL, place in ultrasonic extractor, extract at a power of 400 W and a temperature of 70°C for 6 min, centrifuge, take out the supernatant to obtain a first concentrated solution, add deionized water to the residue, the mass volume ratio of the residue to deionized water is 2:80 g / mL, repeat the above ultrasonic extraction method to obtain a second concentrated solution;

[0059] S2, preparation of liquid I: 6000 mL of the first concentrated solution and 4000 mL of the second concentrated solution were mixed evenly, 2.5 kg of auxiliary materials were added, and the mixture was heated to 60° C. and stirred for 20 min at a stirring rate of 500 rpm to obtain liquid I;

[0060] S3. Use a coating machine to coat the above-mentioned I liquid on the non-woven fabric surface layer, and the coating layer thickness is 0.1-0.3 mm. Then, cure it at room temperature in a clean room to obtain a disposable postoperative dressing plant concentrated film.

[0061] Comparative Example 2

[0062] The difference between this comparative example and Example 4 is that the material comprises the following raw materials by weight: shea butter 0.1 kg, melaleuca oil 0.2 kg, rapeseed polypeptide 0.1 kg, seaweed active peptide 0.5 kg, p-anisic acid 0.01 kg;

[0063] Specifically, it is a disposable postoperative dressing plant concentrated film: it includes an extracted plant concentrated solution, auxiliary materials and a base material, wherein the extracted plant concentrated solution includes the following raw materials by weight per 10 liters: 1.8 kg of honeysuckle, 2 kg of wormwood, 1.2 kg of dandelion, 1 kg of safflower, 2.5 kg of gardenia, and 2.5 kg of aloe; the auxiliary materials include the following raw materials by weight: 0.75 kg of camphor, 0.75 kg of menthol, 0.75 kg of borneol, and 0.25 kg of polyvinyl alcohol; the base material includes the following raw materials by weight: 0.1 kg of shea butter, 0.2 kg of melaleuca oil, 0.1 kg of rapeseed polypeptide, 0.5 kg of seaweed active peptide, and 0.01 kg of p-anisic acid, and the molecular weight of the seaweed active peptide is 5000-1000 Da;

[0064] The above-mentioned concentrated membrane is prepared by the following method:

[0065] S1, extracting plant concentrate: wash, remove impurities, dry, chop and dry the above honeysuckle, wormwood, dandelion, safflower, gardenia and aloe, grind to 110 mesh sieve to form mixed powder after drying, add deionized water, stir evenly, the mass volume ratio of mixed powder to deionized water is 2:80 g / mL, place in ultrasonic extractor, extract at power of 400 W and temperature of 70°C for 6 min, centrifuge and separate, take out supernatant to obtain first concentrated solution, add deionized water to the residue, the mass volume ratio of residue to deionized water is 2:80 g / mL, repeat the above ultrasonic extraction method to obtain second concentrated solution;

[0066] S2. Preparation of liquid I: Mix the first concentrated solution and the second concentrated solution in a volume ratio of 6:4, add auxiliary materials, heat to 60° C. and stir for 20 min at a stirring rate of 500 rpm to obtain liquid I;

[0067] S3. Preparation of liquid II: slowly add the material into liquid I, stirring until the mixture is uniformly mixed, and then high-speed homogenization is performed at 60° C. The high-speed homogenization condition rate is 10,000 rpm, and the homogenization time is 15 min to obtain liquid II.

[0068] S4. Use a coating machine to coat the above II liquid on the non-woven fabric surface layer, with a coating layer thickness of 0.2 mm, and then cure it at room temperature in a clean room to obtain a disposable postoperative dressing plant concentrated film.

[0069] Comparative Example 3

[0070] The difference between this comparative example and Example 4 is that shea butter and melaleuca oil are replaced by equal amounts of palm oil and rapeseed oil in the materials.

[0071] Specifically, it is a disposable postoperative dressing plant concentrated film: it includes an extracted plant concentrated solution, auxiliary materials and a base material, wherein the extracted plant concentrated solution includes the following raw materials by weight per 10 liters: 1.8 kg of honeysuckle, 2 kg of wormwood, 1.2 kg of dandelion, 1 kg of safflower, 2.5 kg of gardenia, and 2.5 kg of aloe, the auxiliary materials include the following raw materials by weight: 0.75 kg of camphor, 0.75 kg of menthol, 0.75 kg of borneol, and 0.25 kg of polyvinyl alcohol, and the base material includes the following raw materials by weight: 0.6 kg of palm oil, 0.9 kg of rapeseed oil, 0.5 kg of rapeseed polypeptide, 0.3 kg of seaweed active peptide, and 0.06 kg of p-anisic acid, and the molecular weight of the seaweed active peptide is 5000-1000 Da;

[0072] The above-mentioned concentrated membrane is prepared by the following method:

[0073] S1, extracting plant concentrate: wash, remove impurities, dry, chop and dry the above honeysuckle, wormwood, dandelion, safflower, gardenia and aloe, grind to 110 mesh sieve to form mixed powder after drying, add deionized water, stir evenly, the mass volume ratio of mixed powder to deionized water is 2:80 g / mL, place in ultrasonic extractor, extract at power of 400 W and temperature of 70°C for 6 min, centrifuge and separate, take out supernatant to obtain first concentrated solution, add deionized water to the residue, the mass volume ratio of residue to deionized water is 2:80 g / mL, repeat the above ultrasonic extraction method to obtain second concentrated solution;

[0074] S2. Preparation of liquid I: Mix the first concentrated solution and the second concentrated solution in a volume ratio of 6:4, add auxiliary materials, heat to 60° C. and stir for 20 min at a stirring rate of 500 rpm to obtain liquid I;

[0075] S3. Preparation of liquid II: slowly add the material into liquid I, stirring until the mixture is uniformly mixed, and then high-speed homogenization is performed at 60° C. The high-speed homogenization condition rate is 10,000 rpm, and the homogenization time is 15 min to obtain liquid II.

[0076] S4. Use a coating machine to coat the above II liquid on the non-woven fabric surface layer, with a coating layer thickness of 0.2 mm, and then cure it at room temperature in a clean room to obtain a disposable postoperative dressing plant concentrated film.

[0077] Comparative Example 4

[0078] The difference between this comparative example and Example 4 is that the feed does not contain rapeseed polypeptide.

[0079] Comparative Example 5

[0080] The difference between this comparative example and Example 4 is that the material does not contain seaweed active peptides.

[0081] 1. Safety Experiment

[0082] The disposable postoperative dressing plant concentrated films of Examples 1-6 and Comparative Examples 1-5 were subjected to animal skin irritation test, skin sensitization test and in vitro cytotoxicity test, respectively, and the results showed that they were safe and non-toxic.

[0083] 2. Antibacterial performance test

[0084] According to the 2020 edition of the Chinese Pharmacopoeia: Key points of the antibacterial efficacy test method, the antibacterial effects of solution I of Example 1 and solution II of Examples 2-6 on Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, and Pseudomonas aeruginosa were tested. The results are shown in Table 1 below:

[0085]

[0086] As can be seen from the above table, the antibacterial activity of the prepared plant concentrated dressing film of the present invention on Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes and Pseudomonas aeruginosa is above 95%, among which the antibacterial effect of Example 4 is better.

[0087] 3. Wound repair experiment

[0088] 1. Experimental animals and groups: 60 SD rats, half male and half female, were randomly divided into 6 groups, corresponding to Example 4 and Comparative Examples 1-5, with 10 rats in each group.

[0089] 2. Experimental method: After the rats were anesthetized with 4% chloral hydrate, the hair on the back of the rats was removed. The hair removal area was 5×4cm. The wound area of ​​cuts, lacerations, abrasions, burns, sutures, etc. was less than 20cm. 2 For superficial grade II skin injuries, the plant concentrated dressing film of the present invention was applied to the wound surface, and the drug was administered twice a day, once in the morning and once in the evening. The healing time and the 7-day average healing rate were calculated respectively.

[0090] Healing rate % = healing area / wound area × 100

[0091] The results are shown in Table 2:

[0092]

[0093] It can be seen from Table 2 that the wound healing speed of rats in Example 4 is higher than that of Comparative Examples 1-5, and the healing rates are all higher than those of Comparative Examples 1-5. The plant concentrated film of the dressing prepared by the present invention significantly shortens the wound healing time, has a good wound repair effect, reduces the secretion of wound exudate, promotes the reconstruction of skin tissue, and accelerates the repair of damaged cells. Compared with Comparative Example 1, the extraction of various raw materials in the plant concentrate according to a specific ratio is conducive to improving the repair ability of the concentrated film, and the addition of the additive helps to maintain normal immune ability. The plant concentrate and the auxiliary materials and additives work synergistically to promote rapid healing of the wound and promote the restoration of skin barrier function.

[0094] Compared with comparative example 2, the rational raw materials selected through scientific proportioning can better assist the plant concentrate in inducing immunity of the skin system and promoting cell proliferation, accelerating cell repair, preventing tissue adhesion, and avoiding secondary damage to the new skin;

[0095] Compared with Comparative Example 3, shea butter and melaleuca oil form a stable hydrophobic structure, which is beneficial to reduce the abnormal permeability of blood vessels at the wound surface and alleviate edema at the wound surface.

[0096] Compared with Comparative Examples 4 and 5, the use of rapeseed polypeptide and seaweed active peptide can regulate the synthesis of wound collagen and contribute to wound healing.

[0097] 4. Scar removal performance test

[0098] 40 patients with hypertrophic scars after surgical suture incisions were selected, including 22 males and 18 females aged 10-50 years old, and were randomly divided into 2 groups, each with 20 people. One experimental group was treated with Liquid II of Example 4, and one control group was treated with commercially available Sifucon dressings, which were applied for 5 hours a day for 30 days.

[0099] Efficacy criteria:

[0100]

[0101] The efficacy results are shown in Table 3:

[0102] Group Number of cases get well efficient invalid Effectiveness / % Example 4 20 18 20 0 100％ Commercially available 20 12 15 5 75％

[0103] As can be seen from Table 3, compared with commercially available products, the postoperative dressing plant concentrated film of the present invention has a better healing effect on the sutured incision wound after surgical operation, and at the same time avoids the formation of severe scars on the wound surface. There is no itching, burning or pain on the scar surface, the congestion of the scar decreases, the color gradually becomes the same as the skin color, the capillaries on the surface of the scar disappear, the scar becomes soft, and the thickness is reduced to the same as that of normal skin, and the scar cells no longer continue to proliferate.

[0104] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A disposable postoperative dressing plant concentrated film, characterized in that: The invention comprises an extracted plant concentrate and auxiliary materials, wherein the extracted plant concentrate comprises the following raw materials in parts by weight: 1-2 parts of honeysuckle, 1-3 parts of wormwood, 1-1.5 parts of dandelion, 0.5-1.5 parts of safflower, 2-3 parts of gardenia, and 2-3 parts of aloe; the auxiliary materials comprise the following raw materials in parts by weight: 0.5-0.8 parts of camphor, 0.5-0.8 parts of menthol, 0.5-0.8 parts of borneol, and 0.2-0.3 parts of polyvinyl alcohol; the postoperative dressing plant concentrate The membrane also includes a material, which includes the following raw materials in parts by weight: 0.4-0.9 parts of shea butter, 0.6-1.2 parts of melaleuca oil, 0.3-0.8 parts of rapeseed polypeptide, 0.2-0.4 parts of seaweed active peptides, and 0.03-0.1 parts of p-anisic acid. The molecular weight of the seaweed active peptides is 5000-1000Da, and the mass volume kg / L ratio of the auxiliary materials, the material and the extracted plant concentrate is 20-30:8-15:

100.

2. The disposable postoperative dressing plant concentrated film according to claim 1, characterized in that: The extracted plant concentrate comprises the following raw materials in parts by weight: 1.8 parts of honeysuckle, 2 parts of wormwood leaves, 1.2 parts of dandelions, 1 part of safflower, 2.5 parts of gardenia, and 2.5 parts of aloe.

3. The disposable postoperative dressing plant concentrated film according to claim 1, characterized in that: The auxiliary materials include the following raw materials in parts by weight: 0.75 parts of camphor, 0.75 parts of menthol, 0.75 parts of borneol, and 0.25 parts of polyvinyl alcohol.

4. The method for preparing a disposable postoperative dressing plant concentrated film according to claim 1, characterized in that: The following steps are involved: S1, extracting plant concentrate: wash, remove impurities, dry, chop and dry the above honeysuckle, wormwood, dandelion, safflower, gardenia and aloe, grind to 100-120 mesh sieve to form mixed powder after drying, add deionized water, stir evenly, the mass volume ratio of mixed powder to deionized water is 1-3:80 g / mL, place in ultrasonic extractor, extract at power of 300-500W and temperature of 60-80°C for 5-7min, centrifuge, take out supernatant to obtain first concentrated solution, add deionized water to the residue, the mass volume ratio of residue to deionized water is 1-3:80 g / mL, repeat the above ultrasonic extraction method to obtain second concentrated solution; S2. Preparation of liquid I: Mix the first concentrated solution and the second concentrated solution in a volume ratio of 6:3-5, add auxiliary materials, heat to 50-70° C. and stir for 10-30 min at a stirring rate of 400-600 rpm to obtain liquid I; S3, preparing liquid II: slowly add the material into liquid I, stirring until the mixture is uniform, and then high-speed homogenizing at 40-80°C to obtain liquid II; S4. Use a coating machine to coat the above II liquid on the non-woven fabric surface layer, with a coating layer thickness of 0.1-0.3 mm, and then cure it at room temperature in a clean room to obtain a disposable postoperative dressing plant concentrated film.

5. The method for preparing a disposable postoperative dressing plant concentrated film according to claim 4, characterized in that: The high-speed homogenization condition of S3 is 8000-12000 rpm and the homogenization time is 10-20 min.

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