Pipeline system, fat and fat matrix ingredient processing system

Abstract

The application discloses a pipeline system and a fat and fat matrix component processing system. The pipeline system is used for processing fat and fat matrix components and comprises a conveying pipeline, a peristaltic pump and a valve body. The conveying pipeline is connected with a containing cavity and a centrifugal cavity. The driving end of the peristaltic pump is detachably connected to the outer surface of the conveying pipeline. The peristaltic pump can drive materials to flow in the conveying pipeline. The valve body is detachably connected to the outer surface of the conveying pipeline. The valve body can control the opening and closing of the conveying pipeline by clamping the outer surface of the conveying pipeline. The peristaltic pump and the valve body are detachably connected with the conveying pipeline and are arranged on the outer surface of the conveying pipeline, so that the conveying pipeline can be conveniently replaced. The conveying pipeline can be used once and has higher cleanliness. The peristaltic pump and the valve body do not contact the materials in the conveying pipeline, so that the materials are not easily polluted and the replacement of the conveying pipeline is more convenient.

Description

Technical Field

[0001] This invention relates to a piping system and a system for processing fat and fat matrix components. Background Technology

[0002] Human adipose tissue is a connective tissue primarily composed of clustered adipocytes supported by loose connective tissue. Like bone marrow and other tissues, adipose tissue is isolated from the human mesenchymal tissue and is rich in an easily separable matrix. In 2002, Zuk et al. published a study defining this adipose-derived regenerative cell population as "processed lipoaspirate cells" (PLA), suggesting that adipose tissue could serve as a source of regenerative cells and possesses long-term therapeutic potential in numerous fields. Similar to mesenchymal stem cells, PLA also has the ability to differentiate into osteoblasts, chondrocytes, myogens, or adipocytes in vitro.

[0003] The research team used cell culture and differentiation, immunofluorescence, spectrophotometry, reverse transcription-polymerase chain reaction (RT-PCR), real-time polymerase chain reaction (RT-PCR), Western blotting, and clonal analysis to detect the components of adipose-derived regenerated cell populations and their regenerative functions compared to mesenchymal stem cells (MSCs). The results showed that, compared to a commercially available human-derived mesenchymal stem cell (MSC) assay, both PLA and MSCs expressed CD29, CD44, CD71, CD90, and CD105 / SH2 and SH3 in surface marker analysis. Both PLA and MSCs expressed the stro-1 marker, used to label bone marrow-isolated multipotent progenitor cells. Flow cytometry results showed that, unlike MSCs, PLA expressed CD49d but not CD106. Even with slight differences in surface marker analysis, the adipose-derived regenerated cell populations possessed differentiation potential for osteogenic, chondrogenic, myogenic, and endothelial processes.

[0004] As a concentrated cell population after isolation and enrichment, adipose-derived regenerated cell populations have functions such as promoting angiogenesis, inhibiting inflammatory responses, and participating in immune regulation.

[0005] Other clinical facilities typically process fat-derived regenerated cell populations manually. Similar fat regenerated cell population processing systems exist abroad, such as TissueGenesis, Cha Station, and Huricell.

[0006] Since 2008, Chinese clinicians have begun combining concentrated fat-derived cell populations with autologous fat for facial rejuvenation, scar treatment, and breast reconstruction to improve graft survival rates in the recipient area. In recent years, as fat-derived regenerated cell populations mixed with fat have become a common clinical procedure, various methods for processing fat and fat-derived regenerated cells have emerged. These processes require the use of tubing to transport liquids and fat. Existing tubing systems often reuse tubing, which can easily lead to contamination during material transport. Summary of the Invention

[0007] The technical problem to be solved by the present invention is to overcome the defects of the prior art in which the repeated use of pipelines easily leads to pollution, and to provide a pipeline system and a fat and fat matrix component processing system.

[0008] The present invention solves the above-mentioned technical problems through the following technical solution:

[0009] A piping system for processing fats and fat matrix components, comprising:

[0010] A delivery pipeline, wherein the delivery pipeline connects the receiving cavity and the centrifuge cavity;

[0011] A peristaltic pump, wherein the drive end of the peristaltic pump is detachably connected to the outer surface of the conveying pipeline, and the peristaltic pump is capable of driving the material to flow within the conveying pipeline;

[0012] A valve body is detachably connected to the outer surface of the delivery pipeline, and the valve body can control the closing and opening of the delivery pipeline by clamping the outer surface of the delivery pipeline.

[0013] In this design, both the peristaltic pump and the valve body are detachably connected to the delivery pipeline and are located on the outer surface of the pipeline, facilitating pipeline replacement. The delivery pipeline is disposable, requiring only one replacement after use, thus preventing contamination and ensuring higher cleanliness. Neither the peristaltic pump nor the valve body comes into contact with the material inside the delivery pipeline, minimizing material contamination and further simplifying pipeline replacement.

[0014] Preferably, the delivery pipeline includes:

[0015] The peristaltic pump is installed on the main pipeline;

[0016] A first accommodating cavity pipeline and a second accommodating cavity pipeline are respectively arranged on both sides of the peristaltic pump and connected to the main pipeline;

[0017] The first centrifugal chamber pipeline and the second centrifugal chamber pipeline are respectively installed on both sides of the peristaltic pump and connected to the main pipeline.

[0018] In this scheme, the peristaltic pump is installed on the main pipeline to facilitate material transportation. The material can be transported between the accommodating cavity and the centrifugal cavity through the first accommodating cavity pipeline, the second accommodating cavity pipeline, the first centrifugal cavity pipeline and the second centrifugal cavity pipeline.

[0019] Preferably, the first accommodating cavity pipeline, the second accommodating cavity pipeline, the first centrifuge cavity pipeline, and the second centrifuge cavity pipeline are all provided with the valve body.

[0020] In this solution, the valve body can control the opening and closing of the first accommodating cavity pipeline, the second accommodating cavity pipeline, the first centrifugal cavity pipeline, and the second centrifugal cavity pipeline, respectively. The controllability of pipeline opening and closing is high, and the material conveying path can be accurately controlled by controlling the valve body.

[0021] Preferably, the delivery pipeline further includes a waste liquid pipeline, one end of which is connected to the main pipeline on one side of the peristaltic pump, and the other end of which is connected to the waste liquid chamber.

[0022] In this solution, the peristaltic pump can drive the material from the main pipeline through the waste liquid pipeline to the waste liquid chamber, facilitating the discharge of waste.

[0023] Preferably, a valve body is provided on the waste liquid pipeline.

[0024] In this solution, the valve body can control the opening and closing of the waste liquid pipeline, so that the waste liquid pipeline can be closed when waste liquid is not needed and opened when waste liquid needs to be discharged, and the controllability of the waste liquid pipeline is high.

[0025] Preferably, the delivery pipeline further includes a buffer solution pipeline, one end of which is connected to the main pipeline on the other side of the peristaltic pump, and the other end of which is connected to the buffer solution chamber.

[0026] In this scheme, the peristaltic pump can transport the material in the buffer chamber to the main pipeline and then to the chamber that needs buffer through the buffer pipeline. Furthermore, the buffer pipeline and the waste liquid pipeline are not on the same side of the peristaltic pump, which realizes the connection between the buffer chamber and the waste liquid chamber. Unnecessary material in the buffer chamber can be transported to the waste liquid chamber.

[0027] Preferably, the delivery pipeline further includes a buffer solution pipeline, one end of which is connected to the main pipeline and the other end of which is connected to the buffer solution chamber.

[0028] In this scheme, the peristaltic pump can transport the material in the buffer chamber to the main pipeline and then to the chamber that needs the buffer through the buffer pipeline.

[0029] Preferably, a valve body is provided on the buffer solution pipeline.

[0030] In this solution, the valve body can control the opening and closing of the buffer solution pipeline, and the controllability of the buffer solution pipeline is high, which is conducive to precise control of the material conveying path.

[0031] Preferably, the piping system further includes a pressure sensor detachably connected to the outer surface of the delivery pipeline, the pressure sensor being used to detect the internal pressure of the delivery pipeline.

[0032] In this solution, on the one hand, the pressure sensor detects the pressure inside the conveying pipeline, which can determine whether there is a leak in the conveying pipeline and ensure the reliable operation of the conveying pipeline; on the other hand, the pressure sensor is detachably connected to the conveying pipeline and does not come into contact with the material inside the conveying pipeline, which is beneficial for the replacement of the conveying pipeline.

[0033] A system for processing fats and fat matrix components, comprising the piping system described above.

[0034] In this solution, the delivery pipeline is easy to replace, which facilitates the use of disposable consumables for the delivery pipeline. With the above-mentioned pipeline system, the fat and fat matrix component processing system is less prone to contamination during the processing of fat and fat matrix components.

[0035] The positive and progressive effects of this invention are as follows: In this invention, both the peristaltic pump and the valve body are detachably connected to the delivery pipeline and are disposed on the outer surface of the delivery pipeline, facilitating the replacement of the delivery pipeline. The delivery pipeline can be used only once and replaced after use, preventing contamination and achieving higher cleanliness. Neither the peristaltic pump nor the valve body comes into contact with the material inside the delivery pipeline, thus reducing the risk of material contamination and making pipeline replacement more convenient. Attached Figure Description

[0036] Figure 1 This is a schematic diagram of the connection relationship of the pipeline system of the present invention;

[0037] Figure 2 This is a schematic diagram of the pipeline system structure of the present invention.

[0038] 100 Guanzhi Road

[0039] Peristaltic pump 150

[0040] First centrifuge chamber tubing 210

[0041] Second centrifuge chamber tubing 220

[0042] First accommodating cavity tubing 230

[0043] Second accommodating cavity tubing 240

[0044] Waste liquid pipeline 250

[0045] Buffer tubing 260

[0046] Valve body 270

[0047] Pressure sensor 300

[0048] 400 Container

[0049] Waste liquid chamber 500

[0050] Centrifuge chamber 600

[0051] Buffer chamber 700 Detailed Implementation

[0052] The present invention will be further illustrated by way of embodiments below, but the present invention is not limited to the scope of the embodiments.

[0053] like Figure 1 and Figure 2 As shown, this embodiment provides a piping system for processing fats and fat matrix components, comprising: a delivery pipeline, a peristaltic pump 150, and a valve body 270. The delivery pipeline connects a receiving chamber 400 and a centrifuge chamber 600. The drive end of the peristaltic pump 150 is detachably connected to the outer surface of the delivery pipeline, enabling the peristaltic pump 150 to drive the material to flow within the delivery pipeline. The valve body 270 is detachably connected to the outer surface of the delivery pipeline, controlling the opening and closing of the delivery pipeline by clamping the outer surface of the pipeline. Both the peristaltic pump 150 and the valve body 270 are detachably connected to the delivery pipeline and are located on the outer surface of the delivery pipeline, facilitating pipeline replacement. The delivery pipeline is disposable, requiring only replacement after use, preventing contamination and ensuring higher cleanliness. Neither the peristaltic pump 150 nor the valve body 270 comes into contact with the material inside the delivery pipeline, reducing the risk of material contamination and making pipeline replacement more convenient. Furthermore, the use of the peristaltic pump 150 facilitates quantitative control.

[0054] In this embodiment, the delivery pipeline uses disposable consumables.

[0055] In this embodiment, valve body 270 is a shut-off valve.

[0056] delivery pipeline in Figure 2 Not shown in the image, but can be combined with Figure 1Specifically, the delivery pipeline includes: a main pipeline 100, a first accommodating cavity pipeline 230, a second accommodating cavity pipeline 240, a first centrifuge chamber pipeline 210, and a second centrifuge chamber pipeline 220. A peristaltic pump 150 is mounted on the main pipeline 100. The first accommodating cavity pipeline 230 and the second accommodating cavity pipeline 240 are respectively located on both sides of the peristaltic pump 150 and connected to the main pipeline 100. The first centrifuge chamber pipeline 210 and the second centrifuge chamber pipeline 220 are respectively located on both sides of the peristaltic pump 150 and connected to the main pipeline 100. The first accommodating cavity pipeline 230 and the second accommodating cavity pipeline 240 are also connected to an accommodating cavity 400, and the first centrifuge chamber pipeline 210 and the second centrifuge chamber pipeline 220 are also connected to a centrifuge chamber 600.

[0057] The peristaltic pump 150 is installed on the main pipeline 100 to facilitate material transport. The material can be transported between the accommodating cavity 400 and the centrifugal cavity 600 through the first accommodating cavity pipeline 230, the second accommodating cavity pipeline 240, the first centrifugal cavity pipeline 210 and the second centrifugal cavity pipeline 220.

[0058] In this embodiment, valve bodies 270 are provided in the first accommodating cavity pipeline 230, the second accommodating cavity pipeline 240, the first centrifugal cavity pipeline 210, and the second centrifugal cavity pipeline 220. The valve bodies 270 can control the opening and closing of the first accommodating cavity pipeline 230, the second accommodating cavity pipeline 240, the first centrifugal cavity pipeline 210, and the second centrifugal cavity pipeline 220 respectively, providing high controllability of pipeline operation. Controlling the valve bodies 270 allows for precise control of the material conveying path.

[0059] In this embodiment, the conveying pipeline also includes a waste liquid pipeline 250. One end of the waste liquid pipeline 250 is connected to the main pipeline 100 on one side of the peristaltic pump 150, and the other end of the waste liquid pipeline 250 is connected to the waste liquid chamber 500. The peristaltic pump 150 can drive the material from the main pipeline 100 through the waste liquid pipeline 250 to the waste liquid chamber 500, facilitating the discharge of waste.

[0060] Among them, the waste liquid chamber 500 uses a waste liquid bag.

[0061] The waste liquid pipeline 250 is equipped with a valve body 270. The valve body 270 can control the opening and closing of the waste liquid pipeline 250, so that the waste liquid pipeline 250 can be closed when waste liquid does not need to be discharged and opened when waste liquid needs to be discharged, and the controllability of the waste liquid pipeline 250 is high.

[0062] In other embodiments, the waste liquid pipeline 250 may not be provided, and the waste liquid may be disposed of in a unified manner after the treatment is completed.

[0063] In this embodiment, the delivery pipeline also includes a buffer solution pipeline 260. One end of the buffer solution pipeline 260 is connected to the main pipeline 100 on the other side of the peristaltic pump 150. The buffer solution pipeline 260 and the waste liquid pipeline 250 are located on opposite sides of the peristaltic pump 150, and the other end of the buffer solution pipeline 260 is connected to the buffer solution chamber 700. The peristaltic pump 150 can deliver the material in the buffer solution chamber 700 to the main pipeline 100 and then to the chamber that requires buffer solution through the buffer solution pipeline 260. Furthermore, the buffer solution pipeline 260 and the waste liquid pipeline 250 are not on the same side of the peristaltic pump 150, thus achieving communication between the buffer solution chamber 700 and the waste liquid chamber 500. Unnecessary material in the buffer solution chamber 700 can be delivered to the waste liquid chamber 500.

[0064] The buffer chamber 700 uses a buffer storage bag.

[0065] In other embodiments, the buffer solution tubing 260 may not be provided, and the buffer solution may be added to the centrifuge chamber 600 or the container chamber 400 in advance.

[0066] In other embodiments, one end of the buffer solution line 260 is connected to the main line 100, and the other end of the buffer solution line 260 is connected to the buffer solution chamber 700. The buffer solution line 260 may also be located on the same side as the waste liquid line 250 and the peristaltic pump 150. The peristaltic pump 150 can transport the material in the buffer solution chamber 700 to the main line 100 and then to the chamber that requires buffer solution through the buffer solution line 260.

[0067] In this embodiment, a valve body 270 is provided on the buffer solution pipeline 260. The valve body 270 can control the opening and closing of the buffer solution pipeline 260, and the controllability of the opening and closing of the buffer solution pipeline 260 is high, which is conducive to precise control of the material conveying path.

[0068] In this embodiment, the delivery pipeline has a main pipeline 100 and six branches: a first accommodating cavity pipeline 230, a second accommodating cavity pipeline 240, a first centrifuge cavity pipeline 210, a second centrifuge cavity pipeline 220, a waste liquid pipeline 250, and a buffer solution pipeline 260. Each branch is equipped with a valve body 270. Any branch located on either side of the peristaltic pump 150 can be connected. By controlling the valve body 270, a variety of different material delivery paths can be provided, resulting in a richer range of delivery paths and high flexibility.

[0069] In this embodiment, the pipeline system also includes a pressure sensor 300, which is detachably connected to the outer surface of the conveying pipeline. The pressure sensor 300 is used to detect the internal pressure of the conveying pipeline. On the one hand, by detecting the internal pressure of the conveying pipeline, the pressure sensor 300 can determine whether there is a leak in the conveying pipeline, ensuring the reliable operation of the conveying pipeline and ensuring that the pipeline pressure is within the normal range during each processing, thus providing the possibility for standardized processing. On the other hand, the pressure sensor 300 is detachably connected to the conveying pipeline and does not come into contact with the material inside the conveying pipeline, which facilitates the replacement of the conveying pipeline.

[0070] Specifically, in this embodiment, there are two pressure sensors 300, which are respectively installed on the delivery pipelines on both sides of the peristaltic pump 150.

[0071] Of course, the pipeline system may not need to be equipped with pressure sensor 300. Before using the pipeline system, it can be tested in advance to ensure that the pipeline pressure is normal and there are no leaks.

[0072] A system for processing fats and fat matrix components, comprising the piping system described above.

[0073] The delivery pipeline is easy to replace, which facilitates the use of disposable consumables for the delivery pipeline. With the above-mentioned pipeline system, the fat and fat matrix component processing system is less prone to contamination during the processing of fat and fat matrix components.

[0074] While specific embodiments of the present invention have been described above, those skilled in the art should understand that these are merely illustrative examples, and the scope of protection of the present invention is defined by the appended claims. Those skilled in the art can make various changes or modifications to these embodiments without departing from the principles and essence of the present invention, but all such changes and modifications fall within the scope of protection of the present invention.

Claims

1. A pipeline system for processing fat and fat matrix ingredients, characterized in that, It comprises: a conveying pipeline, which is in communication with the accommodation cavity, the centrifugal cavity, the waste liquid cavity and the buffer cavity; a peristaltic pump, the driving end of which is detachably connected to the outer surface of the conveying pipeline, and the peristaltic pump is capable of driving the material to flow in the conveying pipeline; a valve body, which is detachably connected to the outer surface of the conveying pipeline, and the valve body is capable of controlling the closing and opening of the conveying pipeline by clamping the outer surface of the conveying pipeline. The conveying pipeline comprises: a main pipeline, the peristaltic pump being arranged on the main pipeline; a first accommodation cavity pipeline and a second accommodation cavity pipeline, which are respectively arranged on the two sides of the peristaltic pump and are in communication with the main pipeline; a first centrifugal cavity pipeline and a second centrifugal cavity pipeline, which are respectively arranged on the two sides of the peristaltic pump and are in communication with the main pipeline; a waste liquid pipeline, one end of which is in communication with the main pipeline, and the other end of which is in communication with the waste liquid cavity; a buffer liquid pipeline, one end of which is in communication with the main pipeline, and the other end of which is in communication with the buffer cavity; The valve body is arranged on the first accommodation cavity pipeline, the second accommodation cavity pipeline, the first centrifugal cavity pipeline, the second centrifugal cavity pipeline and the waste liquid pipeline.

2. The plumbing system of claim 1, wherein, The valve body is arranged on the buffer liquid pipeline.

3. The line system according to claim 1 or 2, characterized in that The pipeline system further comprises a pressure sensor, which is detachably connected to the outer surface of the conveying pipeline, and the pressure sensor is used for detecting the internal pressure of the conveying pipeline.

4. A fat and fat-based ingredient processing system characterized by, The pipeline system comprises any one of claims 1-3.

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