A multilayer hybrid core microreactor combining punched and inserted mesh holes

Abstract

The application discloses a multi-layer mixed core micro-reactor with combined row holes and sheet insertion holes, which comprises a rectangular flat tube-shaped outer sleeve and a multi-layer combined rectangular insertion sheet inserted into the inner cavity of the outer sleeve. The rectangular insertion sheet is made by arranging row holes with holes at both ends on the upper surface and / or lower surface of a rectangular long strip plate and regularly arranging mesh holes on the rectangular insertion sheet. The combined row holes and mesh holes of the mixed core are related to various variable technical specifications, including symmetric structures and asymmetric structures. The combination and size of the row holes and mesh holes, the shape and size of the holes, and the different combinations of the multi-layer insertion sheets can be conveniently adjusted to meet different requirements in actual processes and production processes. The application mainly solves the problems of the existing micro-reactor, such as difficult cleaning after scaling, time-consuming disassembly and assembly process, inconvenient replacement of mixed units, and low design flexibility of the mixed core.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of micro-reactors, in particular to a multi-layer mixed core micro-reactor with a combination of row holes and sheet insertion mesh holes. BACKGROUND

[0002] Micro-reactors can complete chemical reactions within a length scale of tens to hundreds of millimeters, and the most typical structure is a micro-channel. In recent years, micro-reactors with detachable mixed cores have become mainstream and are widely used in the pharmaceutical and chemical industries that require high maintenance and cleaning of equipment in continuous production processes. Many of these micro-reactors involve the design and use of micro-holes, such as the company's CN215917350U, CN216260684U, CN215540778U, and CN215842929U, which are all cylindrical mixed cores with holes that can be detached. The mixed core is a core component of the micro-reactor, which can significantly improve the mixing performance of the micro-reactor, thereby improving its reaction effect.

[0003] However, the above-mentioned mixed core structure is relatively complex and is only suitable for the design of sleeve-type micro-channel reactors, and cannot meet the needs of rectangular flat tube-type micro-reactors with larger heat exchange areas compared to sleeve-type micro-reactors or tube-type reactors. Therefore, there is an urgent need to develop a multi-layer mixed core micro-reactor that is suitable for rectangular flat tube sleeve pipes, has a simple mixed core structure that is easy to process, and has a variety of hole structure combination designs. SUMMARY

[0004] The present application aims to at least partially solve one of the problems in the related art. To this end, one object of the present application is to provide a multi-layer mixed core micro-reactor with a combination of row holes and sheet insertion mesh holes, which solves the problems of complex mixed core structure, inconvenient processing, and unsatisfactory mixing effect.

[0005] According to the present application, a multi-layer mixed core micro-reactor with a combination of row holes and sheet insertion mesh holes is provided, which includes a rectangular flat tube-shaped outer sleeve (10) and a multi-layer combined rectangular sheet (1) inserted into the inner cavity of the outer sleeve (10). The rectangular sheet (1) is made of a rectangular strip plate with two-end hole row tubular channels arranged on the upper surface and / or lower surface and regularly arranged mesh holes on the rectangular sheet (1). The flow direction of the row channels is basically parallel to the plane of the rectangular sheet.

[0006] In some embodiments of the present application, the upper surface row channels and the lower surface row channels of the rectangular long strip are staggered, which can be straight channels or curved channels with streamline shape, and the size of the inlet and outlet at both ends of the row channels can be the same or different; the mesh holes on the rectangular insert (1) are arranged at one end of the front side of the row channels or at the middle position of the front side of two adjacent row channels, or the mesh holes on the rectangular insert (1) are arranged below the row channels.

[0007] In some embodiments of the present application, in addition to the holes at both ends of the upper surface row channels and the lower surface row channels, strip-shaped openings or notches suitable for channel streamline can also be arranged on the channel wall outside the plane of the rectangular insert.

[0008] In some embodiments of the present application, the row channels can also be provided with holes at only one end, and the holes of the row channels arranged on the upper and lower surfaces are all directed to the same direction, and the mesh holes on the rectangular insert (1) are arranged below the row channels and the length of the mesh holes is greater than the length of the row channels.

[0009] In some embodiments of the present application, the row channels on the rectangular insert (1) are one or a combination of semi-cylindrical row channels, quarter-spherical row channels, quarter-olive ball row channels, and half-horn row channels; when the mesh holes are arranged below the row channels, the shape of the mesh holes is one of semi-circular holes, circular holes, elliptical holes, square holes, rectangular holes, triangular holes, and five-pointed star-shaped holes. The shape of the mesh holes can also be one or more of inclined strip-shaped, fishbone-shaped, herringbone-shaped, pill-shaped, octagonal holes, eight-character holes, cross-shaped holes, plum blossom-shaped holes, rhombus-shaped holes, fish eye-shaped holes, special-shaped holes, combination-shaped holes, and louvered holes.

[0010] In some embodiments of the present application, the number of rectangular inserts inserted into each outer sleeve (10) is not less than 3, the total thickness of the combined rectangular inserts (1) is 1-10% less than the inner cavity height of the outer sleeve (10), and the ratio of the inner cavity height to the width of the outer sleeve (10) is 1:2-20.

[0011] In some embodiments of the present application, the thickness of the rectangular insert (1) is 0.1-5 mm, the width is 5-50 mm, and the length is 50-1500 mm.

[0012] In some embodiments of the present application, the material of the rectangular insert (1) is one or more of galvanized steel plate, cold and hot rolled plate, copper plate, nickel plate, stainless steel plate, aluminum alloy plate, hastelloy, polymer material, ceramic, graphene, and silicon carbide.

[0013] In some embodiments of the present application, a plurality of the outer sleeve (10) are connected in parallel to form a unit, and a plurality of units formed by the outer sleeve (10) are connected in series to form an integrated micro reactor; the two ends of the outer sleeve (10) are sealed by end caps, and sealing gaskets are arranged between the end caps and the outer sleeve, and the end caps are fixed on the outer sleeve (10) by screws.

[0014] In some embodiments of the present application, the roughness Ra of the opening of the multi-layer mixed core opening surface combined with the row hole and the sheet hole is not greater than 0.8 μm.

[0015] In some embodiments of the present application, the specific steps are as follows:

[0016] S1: stack the multi-layer rectangular sheet (1), if the rectangular sheet (1) is provided with a row of channels on one side, the rows of channels on the upper and lower adjacent rectangular sheets (1) correspond to each other, and if the rectangular sheet (1) is provided with a row of channels on both sides, the protrusions on the upper surface of the lower layer rectangular sheet (1) correspond to the non-protrusion positions on the lower surface of the upper layer rectangular sheet (1);

[0017] S2: seal the two ends of the outer sleeve (10) with end caps, and arrange sealing gaskets between the end caps and the outer sleeve (10), and fix the end caps on the outer sleeve (10) by screws;

[0018] S3: a plurality of the outer sleeve (10) are connected in parallel to form a unit, and a plurality of units formed by the outer sleeve (10) are connected in series to form an integrated micro reactor.

[0019] The advantages of the present application are as follows, but are not limited thereto: 1) the rectangular flat channel in the inner cavity of the outer sleeve has a larger specific surface area than the tubular channel, and the heat exchange performance of the process in the overall micro reactor is obviously improved; 2) the mixed core combined with the row hole and the sheet hole in the single layer promotes the mixing of the materials in the single layer and realizes the complex channel turbulence between the layers, thereby improving the reaction mixing effect; 3) the detachable rectangular staggered hole mixed core structure is simple in design and low in processing cost, and is convenient for assembly, disassembly, equipment cleaning and maintenance. BRIEF DESCRIPTION OF DRAWINGS

[0020] The accompanying drawings are included to provide a further understanding of the present application, and constitute a part of the specification, and are used to explain the present application together with embodiments of the present application, and do not constitute a limitation on the present application. In the drawings:

[0021] Figure 1 A structure diagram of a multi-layer mixed core micro reactor combined with row holes and sheet holes is provided for the present application (half-cylinder row channel).

[0022] Figure 2Structure diagram of the rectangular insert with half-cylinder array channel of the present application.

[0023] Figure 3 Structure diagram of the rectangular insert with half-cylinder array channel of the present application.

[0024] Figure 4 Structure diagram of the rectangular insert with quarter-sphere single-surface array channel of the present application (mesh hole below the array channel).

[0025] Figure 5 Structure diagram of the rectangular insert with quarter-sphere double-surface array channel of the present application (mesh hole below the array channel).

[0026] Figure 6 Structure diagram of the rectangular insert with quarter-sphere double-surface array channel of the present application (mesh hole below the array channel).

[0027] Figure 7 Structure diagram of the rectangular insert with half-cylinder two-surface array channel of the present application (hole in the middle of the end of the array channel).

[0028] Figure 8 Structure diagram of the rectangular insert with half-cylinder two-surface array channel of the present application (hole in the middle of the end of the array channel).

[0029] Figure 9 Structure diagram of the rectangular insert with half-cylinder two-surface array channel of the present application (hole in the middle of the end of the array channel).

[0030] Figure 10 Structure diagram of the rectangular insert with half-cylinder two-surface array channel of the present application (hole in the middle of the end of the array channel).

[0031] Figure 11 Structure diagram of the rectangular insert with half-cylinder two-surface array channel of the present application (hole in the middle of the end of the array channel).

[0032] Figure: 1, rectangular insert; 2, half-cylinder array channel; 3, strip mesh hole; 4, quarter-sphere array channel (upper surface); 40, mesh hole matched with the sphere array channel; 41, quarter-sphere array channel (lower surface); 5, half-cylinder array channel (mesh hole in the end, upper surface); 51, half-cylinder array channel (mesh hole in the end, lower surface); 6, half-cylinder array channel (end semi-circular mesh hole, upper surface); 60, semi-circular mesh hole; 61, half-cylinder array channel (end semi-circular mesh hole, lower surface); 7, half-horn array channel; 71, mesh hole below the half-horn array channel. DETAILED DESCRIPTION

[0033] The technical solutions in the embodiments of the present application will be clearly and completely described with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments of the present application.

[0034] The present application provides a multi-layer mixed core micro-reactor with row holes and sheet insertion holes, which comprises a rectangular flat tube-shaped outer sleeve 10 and a multi-layer combined rectangular sheet 1 inserted into the inner cavity of the outer sleeve 10. The rectangular sheet 1 is provided with two-end hole row tubular channels on the upper surface and / or lower surface of the rectangular long strip plate and is provided with regularly arranged insertion holes.

[0035] The row channels on the upper surface and the row channels on the lower surface of the rectangular long strip plate are staggered, which can be straight channels or curved channels with streamline shape. The sizes of the inlet and outlet of the two ends of the row channels can be the same or different. The insertion holes on the rectangular sheet 1 are arranged at the front side of one end of the row channels or at the middle position of the front side of two adjacent row channels. Alternatively, the insertion holes on the rectangular sheet 1 are arranged below the row channels.

[0036] The row channels can be provided with holes only at one end. The holes of the row channels arranged on the upper surface and the lower surface are all directed to the same direction. The insertion holes on the rectangular sheet 1 are arranged below the row channels and the length of the insertion holes is greater than the length of the row channels.

[0037] When the insertion holes are arranged below the row channels, the holes on the row channels are communicated with the insertion holes, so that the holes on the row channels are communicated with the rectangular sheet 1. The liquid flows directly from the holes into the insertion holes, so that the liquid is subjected to up-down surface flow. When the insertion holes are arranged at the end of the row channels, the liquid flows between the multi-layer combined rectangular sheets 1 and the liquid is subjected to up-down flow through the insertion holes at the end. The row channels play a supporting and flow limiting role.

[0038] The row channels are arranged in an array or staggered (the middle axes of two adjacent row channels in the upper horizontal row are in the same straight line with the row channels in the next row). When the insertion holes on the rectangular sheet 1 are arranged below the row channels, the length of the insertion holes is greater than the length of the row channels. Since the liquid flowing to the position of the row channels is blocked, the liquid directly flows through the insertion holes at the end of the blocked position, that is, the additional length of the insertion holes compared with the row channels greatly improves the flowability of the liquid. If there is no additional length, the liquid only flows in the interlayer due to the blockage.

[0039] When the rectangular sheet 1 is provided with insertion holes below the row channels, the insertion holes can be composed of 1-5 parallel strip-shaped insertion holes 3. The multiple strip-shaped insertion holes 3 can divide the liquid and play a better mixing effect, but too many insertion holes will make the gap between the insertion holes small, which is not conducive to the flow of the liquid.

[0040] The number of combined rectangular inserts inserted into each outer sleeve 10 is not less than 3, the total thickness of the combined rectangular inserts 1 is 1-10% less than the inner cavity height of the outer sleeve 10, and the ratio of the inner cavity height to the width of the outer sleeve 10 is 1:2-20. The thickness of the rectangular insert 1 is between 0.1-5 mm, the width is between 5-50 mm, and the length is between 50-1500 mm. More than three combined inserts have a better effect on forming turbulence for multiple fluid streams, preferably 3-5, and too many will increase the height of the semi-cylindrical row channel 2, which cannot achieve the micro-reaction effect of the flat channel.

[0041] The material of the rectangular insert 1 is one or a combination of galvanized steel sheet, cold and hot rolled sheet, copper sheet, nickel sheet, stainless steel sheet, aluminum alloy sheet, hastelloy, polymer material, ceramic, graphene, or silicon carbide.

[0042] The row channel on the rectangular insert 1 is one or a combination of semi-cylindrical row channel, quarter-sphere row channel, quarter-rugby row channel, and half-trumpet row channel.

[0043] The row channel on the upper surface of the rectangular long strip plate and the row channel on the lower surface can be provided with strip-shaped openings or notches suitable for the flow lines of the channels on the channel wall outside the plane of the rectangular insert, except that holes are provided at both ends.

[0044] When the mesh hole is provided at one end of the row channel, the mesh hole shape is one of a semi-circular hole, a circular hole, an elliptical hole, a square hole, a rectangular hole, a triangular hole, and a five-pointed star hole.

[0045] The mesh hole shape can also be one or more of an inclined strip shape, a fishbone shape, a herringbone shape, a pill shape, an octagonal hole, an eight-character hole, a cross hole, a plum blossom hole, a rhombus hole, a fish eye hole, a special-shaped hole, a combined hole, and a louver hole.

[0046] Multiple outer sleeves 10 are connected in parallel to form a unit, and multiple units formed by the multiple outer sleeves 10 are connected in series to form an integrated micro-reactor.

[0047] The liquid flow rate and flow in each outer sleeve 10 are limited within a certain range to ensure that a large flow rate and flow rate are used to connect multiple outer sleeves 10 in parallel to form a unit, and multiple units formed by the multiple outer sleeves 10 are connected in series to form an integrated micro-reactor to improve the reaction speed.

[0048] The surface roughness Ra of the rectangular insert is not greater than 0.8 μm. This prevents scratches caused by additional friction between the porous insert and the outer sleeve during disassembly and assembly, avoids solid foreign matter from being stuck on the reactor wall or the dead angle of the porous structure, increases the difficulty of cleaning, and reduces unnecessary pressure drop.

[0049] A method for installing a multi-layer hybrid core micro-reactor combined with a row of holes and a sheet of inserts, the specific steps are as follows:

[0050] S1: Combine the multi-layer rectangular inserts 1, if the rectangular inserts 1 are single-sidedly provided with a row of channels, then the rows of channels on the upper and lower adjacent rectangular inserts 1 correspond to each other, and if the rectangular inserts 1 are provided with a row of channels on both sides, then the row of channels on the upper surface of the lower layer of rectangular inserts 1 correspond to the non-row of channels position on the lower surface of the upper layer of rectangular inserts 1;

[0051] S2: Use a seal head to seal both ends of the outer sleeve 10, a sealing gasket is placed between the seal head and the outer sleeve 10, and a screw is used to fix the seal head on the outer sleeve 10;

[0052] S3: A plurality of outer sleeves 10 are connected in parallel to form a unit, a plurality of units formed by the outer sleeves 10 are connected in series to form an integrated micro-reactor, and a plurality of units formed by the outer sleeves are connected in series to form an integrated micro-reactor.

[0053] A multi-layer hybrid core combined with a row of holes and a sheet of inserts, embodiment 2: disassembly.

[0054] During the actual use of the rectangular porous insert, if scaling or blockage occurs inside the equipment, cleaning and maintenance are required. The screws on the seal heads at the inlet and outlet ends can be loosened, and after the seal heads are removed, a thin rod is used to push the rectangular insert out a small section at one end of the inlet and outlet, and then the insert is pulled out directly from the other end, thereby completing the disassembly process.

[0055] Cleaning and maintenance of a multi-layer hybrid core combined with a row of holes and a sheet of inserts.

[0056] The rectangular insert is cleaned and maintained, usually by immersing it in a container containing cleaning agent for a certain period of time, and an ultrasonic cleaner can also be used to assist in cleaning, and then a fine brush is used for brushing, thereby completing the cleaning process.

[0057] Reassembly (including replacement of hybrid core elements) of a multi-layer hybrid core combined with a row of holes and a sheet of inserts.

[0058] The multi-layer hybrid core of the combination of the row holes and the insert sheet mesh can be reassembled after cleaning and maintenance. If some of the cores are found to be seriously clogged (additional maintenance is required in addition to ultrasonic cleaning) and need to be replaced, or the actual situation requires replacement of different specifications of combined silk screen hybrid cores, the appropriate multi-layer hybrid core can be selected according to the situation. For example, the rectangular multi-hole combined hybrid core involves a variety of variable technical specifications, including symmetric and asymmetric structures, and the combination and size of the upper and lower surface rows of channels, the shape and size of the insert sheet mesh opening, the strip opening or cutout on the row channel wall according to the channel shape, and the different combinations of multi-layer rectangular multi-hole combined inserts, etc. can be easily adjusted to meet different requirements in the actual process and production process

[0059] The micro-channel reactor combined by the multi-layer hybrid core of the combination of the row holes and the insert sheet mesh can be easily used for the synthesis process of pharmaceutical intermediates prone to fouling and clogging. Compared with the conventional all-disassembled Bayer micro-reactor Meander micro-reactor, the time required for micro-reactor maintenance operation is shortened by at least 30% or even 60% from the beginning of disassembly, cleaning and maintenance, possible replacement of hybrid cores or units to reassembly when fouling or scaling (such as rapid increase in system pressure drop) is found. The maintenance efficiency of the process optimization or production process is greatly improved, and the technical requirements for the operator are not high.

[0060] The above is only the preferred specific embodiment of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art can make equivalent replacements or changes to the technical solutions and inventive concepts of the present application within the technical scope disclosed by the present application, which should be covered within the protection scope of the present application.

Claims

1. A multilayer hybrid core microreactor of a combination of punched and inserted mesh, characterized by: The outer sleeve (10) includes a rectangular flat tube shape, and a multi-layer combined rectangular insert (1) inserted into the inner cavity of the outer sleeve (10), wherein the rectangular insert (1) is provided with two-end hole arranged channels on the upper surface and / or lower surface of a rectangular long strip plate, and regularly arranged mesh holes on the rectangular insert (1); the flow direction of the arranged channels is substantially parallel to the plane of the rectangular insert; The material of the rectangular insert (1) is one or more of galvanized steel plate, cold / hot rolled plate, copper plate, nickel plate, stainless steel plate, aluminum alloy plate, hastelloy, polymer material, ceramic, graphene and silicon carbide.

2. A multi-layer hybrid microreactor of the type having a combination of punched and inserted sheets as claimed in claim 1, characterized in that: The upper surface arranged channels and the lower surface arranged channels on the rectangular long strip plate are staggered and distributed, and are selected from one of straight channels or streamline curved channels; the size of the inlet and outlet of the two ends of the arranged channels is selected from one of the same or different; the mesh holes on the rectangular insert (1) are arranged at the front side of one end of the arranged channels or the middle position of the front side of the same end of two adjacent arranged channels, or the mesh holes on the rectangular insert (1) are arranged below the arranged channels.

3. A multi-layer hybrid microreactor of the type comprising a plurality of layers of perforated sheets according to claim 1, characterized in that: In addition to the two ends of the upper surface arranged channels and the lower surface arranged channels being provided with holes, strip-shaped openings or notches suitable for channel streamline can also be arranged on the channel wall outside the plane of the rectangular insert.

4. A multi-layer hybrid microreactor of the type having a combination of punched and inserted sheets as claimed in claim 1, characterized in that: The arranged channels can also have only one end provided with holes, the holes of the arranged channels arranged on the upper and lower surfaces are all directed to the same direction, and the mesh holes on the rectangular insert (1) are arranged below the arranged channels and the length of the mesh holes is greater than the length of the arranged channels.

5. A multi-layer hybrid microreactor of the type having a combination of punched and inserted sheets as claimed in claim 1, characterized in that: The arranged channels on the rectangular insert (1) are one or a combination of half-cylindrical arranged channels, quarter-spherical arranged channels, quarter-olive ball arranged channels and half-horn arranged channels; when the mesh holes are arranged below the arranged channels, the shape of the mesh holes is one of half-circular holes, circular holes, elliptical holes, square holes, rectangular holes, triangular holes and five-pointed star-shaped holes; the shape of the mesh holes can also be one or more of inclined strip-shaped, fishbone-shaped, herringbone-shaped, pill-shaped, octagonal holes, eight-character holes, cross-shaped holes, plum blossom-shaped holes, rhombus-shaped holes, fish eye-shaped holes, special-shaped holes, combined-shaped holes and louvered holes.

6. A multi-layer hybrid microreactor of the type having a combination of punched and inserted sheets as claimed in claim 1, characterized in that: The number of the rectangular inserts inserted into each outer sleeve (10) is not less than 3, the total thickness of the combined rectangular inserts is 1-10% less than the inner cavity height of the outer sleeve (10), and the ratio of the inner cavity height to the width of the outer sleeve (10) is 1:2-20.

7. The multilayer hybrid core microreactor with a combination of perforated and insert mesh according to claim 1, characterized in that: The thickness of the rectangular insert (1) is 0.1-5 mm, the width is 5-50 mm, and the length is 50-1500 mm.

8. The multi-layer hybrid microreactor of claim 1, wherein: the plurality of layers comprises a plurality of layers of perforated sheets and a plurality of layers of punched sheets; and the plurality of layers of punched sheets are arranged in a plurality of layers of punched sheets and a plurality of layers of perforated sheets. A plurality of outer sleeves (10) are connected in parallel to form a unit, and a plurality of units formed by the outer sleeves (10) are connected in series to form an integrated micro-reactor; the two ends of the outer sleeve (10) are sealed by end caps, and a sealing gasket is arranged at the contact position between the end cap and the outer sleeve, and the end cap is fixed on the outer sleeve (10) by a screw.

9. A method of installing a multilayer hybrid-junction microreactor of the type having a combination of drilled and punched apertures, characterized by: The specific steps are as follows: S1: stack the multi-layer rectangular inserts (1), if the rectangular inserts (1) are single-sidedly provided with rows of channels, then the rows of channels on the upper and lower adjacent rectangular inserts (1) correspond to each other, if the rectangular inserts (1) are provided with rows of channels on both sides, then the protrusions on the upper surface of the lower layer rectangular inserts (1) correspond to the non-protrusion positions on the lower surface of the upper layer rectangular inserts (1); S2: seal the two ends of the outer sleeve (10) with end caps, a sealing gasket is arranged between the end cap and the outer sleeve (10), and the end cap is fixed on the outer sleeve (10) by screws; S3: a plurality of outer sleeves (10) are connected in parallel to form a unit, and a plurality of units formed by the outer sleeves (10) are connected in series to form an integrated micro reactor.

Images