Composition for preventing and treating chapped skin, preparation method and application thereof

Abstract

The present invention relates to a composition for preventing and treating chapped skin and its preparation method and application, and belongs to the technical field of daily chemical products. The composition includes the following components in parts by weight: licorice chalcone A: 0.05-1 part, tea tree oil: 0.5-8 part, lithospermum officinale oil: 1-10 part, ophiopogon root extract: 2-15 parts; the present invention adopts the compounding of specific components, and by controlling the weight of each component in the composition, each component is coordinated with each other, and a synergistic effect is played, and by multiple angles such as moisturizing, anti-inflammatory, antibacterial and promoting skin regeneration, skin healing is helped, and the purpose of preventing and treating chapped skin can be achieved, with significant effect and mild effect; and the composition has antibacterial effect, can replace chemical preservatives, and reduces irritation to the skin during use. The anti-chapped cream prepared by the present invention has a liquid crystal structure, can provide better skin feel and excellent stability, and can prolong the action time of active substances.

Description

Technical Field

[0001] The present invention relates to the technical field of daily chemical products, in particular to a composition for preventing and treating skin chapped skin, and a preparation method and application thereof. Background Art

[0002] Chapped skin is a common skin disease in autumn and winter. Children and the elderly are at high risk of this disease due to their weak skin barrier. In the early stages of chapped skin, symptoms usually include dryness, flaking, redness, swelling, and cracking on the face, fingers, palms, outer feet, or heels. At this stage, there are no bleeding or pain symptoms. As the disease worsens, it can affect the superficial dermis, causing small, shallow cracks of varying lengths. Although mildly painful, they do not bleed. In more severe cases, the cracks can follow the direction of the skin grain, involving the deeper dermis and even the subcutaneous tissue, often accompanied by significant bleeding and severe pain, affecting the patient's local skin function, as well as the patient's normal study, exercise, and life. Therefore, this disease should not be ignored.

[0003] Common treatments for chapped skin include moisturizing and nourishing the skin, and in more severe cases, hormones for anti-inflammatory treatment. For example, chapped skin creams are formulated with urea, polysaccharide moisturizers, silicone oil, lanolin, and plant oils to soften the stratum corneum and increase its water content. However, while increasing the water content and softening the stratum corneum can improve dryness and flaking to a certain extent, redness, swelling, redness, or bleeding can be difficult to recover from, and the treatment cycle is lengthy, making them unsuitable for children and the elderly, who have weaker skin barriers.

[0004] In view of the defects of the above-mentioned products for treating chapped skin, the current research focus is to develop a composition for preventing and treating chapped skin that can effectively solve the problem of chapped skin and has good skin feel and stability when used. Summary of the Invention

[0005] The object of the present invention is to overcome the deficiencies of the above-mentioned prior art and provide a composition for preventing and treating skin chapped skin, as well as its preparation method and application. The composition has excellent anti-chapped effect and antibacterial effect, and is mild and non-irritating when used, and is particularly suitable for children and the elderly.

[0006] To achieve the above object, the technical solution adopted by the present invention is:

[0007] In a first aspect, the present invention provides a composition for preventing and treating chapped skin, comprising the following components in parts by weight: 0.05-1 part of licorice chalcone A, 0.5-8 parts of tea tree oil, 1-10 parts of lithospermum oil, and 2-15 parts of ophiopogon root extract.

[0008] Licorice chalcone A has significant anti-inflammatory properties, and its anti-inflammatory effect is better than dexamethasone and hydrocortisone. It can be used to treat atopic dermatitis, skin sensitivity, redness, and resist external stimuli. It can also be used to treat rosacea, red blood streaks, and facial flushing. It also has good antioxidant properties.

[0009] Tea tree oil, also known as Melaleuca alternifolia oil, is a colorless to light yellow essential oil obtained by steam distillation of the fresh branches and leaves of the Melaleuca alternifolia plant. This essential oil has a good broad-spectrum bactericidal effect and is a natural antibacterial agent. It has a strong inhibitory effect on fungi and bacteria both in vivo and in vitro. According to research, tea tree oil contains a variety of active ingredients, such as 4-terpineol, which has a strong antibacterial effect on Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, etc. Tea tree oil is widely used in various fields due to the multiple active ingredients it contains. In addition, tea tree oil is mild in nature and can be used directly on the skin surface. Therefore, it is particularly common in the preparation of various skin topical preparations and cosmetics.

[0010] Lithospermum oil is a long-standing topical medicine for the clinical treatment of burns and scalds. It comes from the Qing Dynasty's "Compendium of Sores and Ulcers" and is included in the 1995 edition of the "Pharmacopoeia of the People's Republic of China". It has good anti-inflammatory activity, can promote the metabolic function of fibroblasts, and accelerate wound healing.

[0011] The Ophiopogon japonicus polysaccharides in Ophiopogon japonicus root extract are mainly oligofructose and fructan with a molecular weight of 500-10000, with fructose accounting for more than 90%. It has excellent moisture absorption and moisturizing properties, and can easily penetrate deep into the skin, strengthening the "tight junction" of the upper layer of the epidermis, which can maintain good hydration of the skin, greatly increasing the content of transmembrane proteins Claudin-1 and ZO-1 related to skin tightness, and promoting the formation of a more orderly and tight membrane network structure in the epidermis. At the same time, it can also increase the content level of natural moisturizing factors in the skin, providing the skin with a long-lasting moisturizing effect from the inside out.

[0012] The inventors unexpectedly discovered that the composition of the present invention adopts a compound of the above-mentioned specific components, and by controlling the weight of each component in the composition, the components cooperate with each other to exert a synergistic effect. It helps skin healing from multiple angles such as moisturizing, anti-inflammatory, antibacterial and promoting skin regeneration, and can achieve the purpose of preventing and treating skin cracks. The effect is significant and the effect is mild.

[0013] In the formulation of the composition for preventing and treating chapped skin of the present invention, the definition of the above components and their contents is very important. Each link is closely linked and directly affects the final effect of the composition for preventing and treating chapped skin.

[0014] As a preferred embodiment of the composition for preventing and treating chapped skin of the present invention, the composition comprises the following components in parts by weight: 0.1-0.5 parts of licorice chalcone A, 1-4 parts of tea tree oil, 2-6 parts of lithospermum oil, and 6-10 parts of ophiopogon root extract. The inventors have found through a large number of exploratory experiments that the components in the above parts by weight can make the final composition more effective in treating chapped skin. After using the anti-chapped product made from the composition, the comprehensive recognition rate of users is greater than 90%.

[0015] As a more preferred embodiment of the composition for preventing and treating chapped skin of the present invention, the composition comprises the following components in parts by weight: 0.3 parts of licorice chalcone A, 2 parts of tea tree oil, 4 parts of lithospermum oil, and 8 parts of ophiopogon root extract. The inventors have found through a large number of exploratory experiments that the components in the above parts by weight can make the final composition more effective in treating chapped skin. After using the anti-chapped product made from the composition, the comprehensive recognition rate of users can be as high as 94%.

[0016] In a second aspect, the present invention provides an anti-chapped cream, wherein the raw materials of the anti-chapped cream include the composition for preventing and treating chapped skin as described in the first aspect.

[0017] As a preferred embodiment of the anti-crack cream of the present invention, the raw materials of the anti-crack cream further include emulsifiers, oils, thickeners and polyols.

[0018] As a more preferred embodiment of the anti-chapped cream of the present invention, the anti-chapped cream comprises the following components in weight percentage: 3.5%-8.5% emulsifier, 6%-10% oil, 9%-15% polyol, 0.6%-1% thickener, 2%-10% composition for preventing and treating chapped skin and the remainder water.

[0019] As a more preferred embodiment of the anti-chapped cream of the present invention, the emulsifier includes at least one of sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, polyglycerol-6 esters and cetearyl alcohol. The present invention uses an emulsifier that can form a liquid crystal structure. The liquid crystal structure can increase the adhesion of the cream and can also control the slow release of active substances, thereby prolonging the action time of the active substances.

[0020] As the most preferred embodiment of the anti-crack cream of the present invention, the emulsifier includes sodium stearoyl lactylate, polyglyceryl-6 esters and cetearyl alcohol.

[0021] As a more preferred embodiment of the anti-chapped cream of the present invention, the oil comprises at least one of olive oil, jojoba oil, meadowfoam seed oil, polydimethylsiloxane and cyclopentasiloxane.

[0022] As the most preferred embodiment of the anti-chapped cream of the present invention, the oil comprises olive oil, meadowfoam seed oil and polydimethylsiloxane.

[0023] As a more preferred embodiment of the anti-crack cream of the present invention, the thickener includes at least one of polyacrylate crosspolymer-6, sodium polyacryloyldimethyl taurate and acrylates / C10-30 alkyl acrylate crosspolymer.

[0024] As the most preferred embodiment of the anti-crack cream of the present invention, the thickener is polyacrylate crosspolymer-6.

[0025] As a more preferred embodiment of the anti-crack cream of the present invention, the polyol is glycerin.

[0026] By adopting the above solution, the anti-crack cream can achieve better compatibility of each component with the composition.

[0027] The present invention also provides a method for preparing the anti-chapped cream, comprising the following steps:

[0028] S1. Heat the oil and emulsifier to 80-85℃ and keep warm for later use;

[0029] S2. Mix deionized water, polyol and thickener evenly, heat to 85-90°C, and keep warm for 30-35 minutes;

[0030] S3, adding the mixture of step S1 to the mixture of step S2, stirring evenly and homogenizing for 5-8 minutes;

[0031] S4, cooling the mixture from step S3 to 40-45° C., then adding the composition for preventing and treating chapped skin, and stirring evenly to obtain the anti-chapped cream.

[0032] Compared with the prior art, the present invention has the following beneficial effects:

[0033] The present invention provides a composition for preventing and treating chapped skin. By adopting a compound of specific components and controlling the weight of each component in the composition, the components cooperate with each other to exert a synergistic effect. The composition helps skin heal from multiple perspectives, such as moisturizing, anti-inflammatory, antibacterial, and promoting skin regeneration, thereby achieving the purpose of preventing and treating chapped skin with significant and mild effects. Furthermore, the composition has an antibacterial effect, can replace chemical preservatives, and reduce skin irritation during use. The anti-chapped cream prepared by the present invention has a liquid crystal structure, can provide a good skin feel and excellent stability, and can prolong the action time of the active substance. DETAILED DESCRIPTION

[0034] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention are clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0035] Unless otherwise specified, the raw materials, methods and equipment used in the present invention are all conventional raw materials, methods and equipment in this technical field.

[0036] Examples 1-5

[0037] The formulas of the compositions for preventing and treating chapped skin described in Examples 1-5 of the present invention are shown in Table 1, and the formula of the anti-chapped cream is shown in Table 2.

[0038] In Examples 1-5, the preparation method of the anti-chapped cream comprises the following steps:

[0039] S1. Heat the oil and emulsifier to 80°C according to the formula in Table 2 and keep warm for later use;

[0040] S2. Mix deionized water, polyol and thickener evenly, heat to 85°C, and keep warm for 30 minutes;

[0041] S3, adding the mixture of step S1 to the mixture of step S2, stirring evenly and homogenizing for 5 minutes;

[0042] S4, cooling the mixture of step S3 to 45° C., then adding the composition for preventing and treating chapped skin, and stirring evenly to obtain the anti-chapped cream.

[0043] Example 6

[0044] The formula of the composition for preventing and treating chapped skin described in Example 6 is the same as that in Example 2, with the only difference being that the formula of the chapped skin cream is different and the preparation method of the chapped skin cream is the same as that of Examples 1-5.

[0045] Table 1

[0046] parts by weight Example 1 Example 2 Example 3 Example 4 Example 5 Licochalcone A 0.1 0.3 0.5 0.05 1 tea tree oil 1 2 4 0.5 8 Lithospermum officinale oil 2 4 6 1 10 Ophiopogon root extract 6 8 10 2 15

[0047] Table 2

[0048]

[0049]

[0050] Comparative Examples 1-4

[0051] The compositions for preventing and treating chapped skin described in Comparative Examples 1-4 of the present invention differ from those in Example 2 only in that one component of the composition for preventing and treating chapped skin is missing. The specific formulas are shown in Table 2. The formulas of the anti-chapped creams described in Comparative Examples 1-4 are the same as those in Example 2, and the preparation methods of the anti-chapped creams described in Comparative Examples 1-4 are the same as those in Example 2.

[0052] Table 3

[0053] parts by weight Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Licochalcone A 0 0.5 0.8 0.9 tea tree oil 2.1 0 4 6 Lithospermum officinale oil 4.1 5 0 7.4 Ophiopogon root extract 8.1 8.8 9.5 0

[0054] Comparative Example 5

[0055] The only difference between this comparative example and the composition for preventing and treating skin chapped skin described in Example 2 is that glycyrrhetinic acid ester is used instead of licochalcone A. The formula and preparation method of the anti-chapped cream described in this comparative example are the same as those in Example 2.

[0056] Comparative Example 6

[0057] The only difference between this comparative example and the composition for preventing and treating chapped skin described in Example 2 is that lavender essential oil is used instead of tea tree oil. The formula and preparation method of the anti-chapped cream described in this comparative example are consistent with those in Example 2.

[0058] Comparative Example 7

[0059] The only difference between this comparative example and the composition for preventing and treating chapped skin described in Example 2 is that chamomile essential oil is used instead of lithospermum oil. The formula and preparation method of the anti-chapped cream described in this comparative example are consistent with those in Example 2.

[0060] Comparative Example 8

[0061] The only difference between this comparative example and the composition for preventing and treating chapped skin is that oat extract is used instead of Ophiopogon japonicus root extract. The formula and preparation method of the anti-chapped cream in this comparative example are consistent with those in Example 2.

[0062] Comparative Examples 9-10

[0063] The formula of the composition for preventing and treating skin chapped skin described in Comparative Examples 9-10 is the same as that in Example 2. The formula of the anti-chapped skin cream is shown in Table 4. The preparation method of the anti-chapped skin cream is the same as that in Example 2.

[0064] Comparative Example 11

[0065] The formula of the anti-chapped cream in this comparative example is the same as that in Example 2, the only difference being that the composition for preventing and treating chapped skin is replaced by water.

[0066] Table 4

[0067] Weight percentage (%) Comparative Example 9 Comparative Example 10 Comparative Example 11 Sodium Stearoyl Lactylate 2 2 2 Polyglycerol-6 esters 3 3 3 Cetearyl Alcohol 2 2 2 olive oil 3 3 3 Limnanthes Alba Seed Oil 2 2 2 Polydimethylsiloxane 3 3 3 glycerin 8 8 8 Polyacrylate Crosspolymer-6 0.6 0.6 0.6 Composition for preventing and treating chapped skin 1 11 0 water margin margin margin

[0068] Test Example 1

[0069] Test method: 260 patients aged 18-60 years with dry and peeling skin on their calves and feet and obvious skin cracking were selected and divided into 13 groups on average. 0.2 mL of each composition for preventing and treating skin cracking described in Examples 1-5 and Comparative Examples 1-8 was evenly applied to the dry and cracked areas of the calves and heels until completely absorbed. The application was done once a day in the morning and evening for one week. During the experiment, the subjects were prohibited from using other soothing or moisturizing preparations on the test areas. The effects of the application were observed after one week.

[0070] Evaluation method: The 7-level scoring method in Table 5 below was used to score the product usage effects of the subjects. The recognition rates (percentage of ≥5 points) for reducing desquamation, reducing redness and swelling, relieving itching and pain, healing of chapped skin, and skin regeneration were calculated respectively. The evaluation results are shown in Table 6 below.

[0071] Table 5

[0072]

[0073] Table 6

[0074]

[0075]

[0076] According to the data in Table 6, after the composition for preventing and treating chapped skin described in the embodiment of the present invention is applied by a patient with obvious chapped skin phenomenon, the recognition rate of reducing desquamation, fading redness and swelling, relieving itching and analgesia, chapped skin healing and skin regeneration is high, and the comprehensive recognition rate is also high. Among them, in the composition for preventing and treating chapped skin described in Example 2, 0.3 parts of licorice chalcone A, 2 parts of tea tree oil, 4 parts of lithospermum oil, 8 parts of ophiopogon root extract, the recognition rate of the obtained composition is the highest. The compositions prepared by Comparative Examples 1-4 are not containing the one in the present invention, and the recognition rates of the various items after being applied by the patient with obvious chapped skin phenomenon are greatly reduced; Comparative Examples 5-8 are to replace a certain active component of the present invention, and the recognition rates of the various items after being applied by the patient with obvious chapped skin phenomenon are also greatly reduced; It can be seen that the composition for preventing and treating chapped skin provided by the present invention, each component synergizes and enhances efficiency, and jointly provides the effect of preventing and treating chapped skin.

[0077] Test Example 2

[0078] Test method: 200 patients aged 18-60 years with dry and peeling skin on their calves and feet and obvious skin cracking were selected and divided into 13 groups on average. 2g of each of the anti-crack creams described in Examples 1-6 and Comparative Examples 9-11 were taken and evenly applied to the dry and cracked areas of the calves and heels until completely absorbed. The creams were used once a day in the morning and evening for one week. During the experiment, the subjects were prohibited from using other soothing or moisturizing preparations on the test areas. The effects of the treatment were observed after one week.

[0079] Control group: commercially available 20% urea ointment.

[0080] Evaluation method: The 7-level scoring method in Table 5 above was used to score the product usage effects of the subjects. The recognition rates (percentage of ≥5 points) for reducing desquamation, reducing redness and swelling, relieving itching and pain, healing of chapped skin, and skin regeneration were calculated respectively. The evaluation results are shown in Table 7 below.

[0081] Table 7

[0082]

[0083]

[0084] According to Table 7 data, after the compositions for preventing and treating chapped skin described in Examples 1-6 of the present invention are made into anti-chapped cream and applied by patients with obvious chapped skin phenomenon, the approval rate of reducing desquamation, fading redness and detumescence, relieving itching and analgesia, chapped skin healing and skin regeneration is all higher, and the comprehensive approval rate is also all higher. Wherein, in the compositions for preventing and treating chapped skin described in Example 2, 0.3 part of licorice chalcone A, 2 parts of tea tree oil, 4 parts of lithospermum oil, 8 parts of ophiopogon root extract, the approval rate of the anti-chapped cream obtained is the highest. The composition content in the anti-chapped cream described in Comparative Examples 9 and 10 is not within the specific scope of the present invention, and from the evaluation result, the effect is also significantly decreased. Comparative Example 11 does not add the application of the compositions for preventing and treating chapped skin described in the present invention, and from the final effect, Comparative Example 11 has the worst effect, and its efficacy all comes from moisturizing and nourishing.

[0085] Test Example 3

[0086] Stability assessment

[0087] Test sample: the anti-crack cream described in Examples 1-6 and Comparative Examples 1-11;

[0088] Test method: Refer to the QB / T 1857-2013 standard for moisturizing creams to conduct heat resistance, cold resistance and cyclic stability tests, as follows:

[0089] 1. Heat resistance test: Place the sample at 48°C and observe after 90 days;

[0090] 2. Cold resistance test: Place the sample in a -10℃ environment and observe after 90 days;

[0091] 3. Cyclic test: Place the sample at 48°C for 12 hours, then place it at -10°C for 12 hours; repeat the cycle three times.

[0092] The results are shown in Table 8 below.

[0093] Table 8

[0094]

[0095]

[0096] Test Example 4

[0097] Antiseptic test: The anti-crack creams described in Examples 1-6 of the present invention and Comparative Examples 1-11 were respectively tested for bacterial, mold, and yeast content after 2, 7, 14, and 28 days, using the 28-day antiseptic single challenge test recommended by the Cosmetic and Fragrance Association (CTFA). The results are shown in Table 9 below.

[0098] Table 9

[0099]

[0100]

[0101]

[0102]

[0103] According to the data in Tables 8 and 9, the compositions for preventing and treating chapped skin described in Examples 1-6 of the present invention have good heat resistance, cold resistance stability and microbial protection effect after being made into anti-chapped creams; Comparative Examples 1-4 lack a certain component in the compositions for preventing and treating chapped skin, resulting in poor stability and microbial protection effect of the anti-chapped creams; Comparative Examples 5-8 deviate from the present invention in the selection of a certain component in the compositions for preventing and treating chapped skin, and the final anti-chapped creams also have poor heat resistance, cold resistance stability and microbial protection effect; the content of the composition for preventing and treating chapped skin in the anti-chapped creams of Comparative Examples 9 and 10 is not within the specific range of the present invention, and Comparative Example 11 is an application without adding the composition for preventing and treating chapped skin described in the present invention. From the final effect, Comparative Examples 9-11 have poor microbial protection effects, and Comparative Example 10 has poor stability due to the addition of an excessive amount of the composition for preventing and treating chapped skin in the anti-chapped cream.

[0104] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. An anti-chapped cream, characterized in that: The anti-chapped cream comprises the following components in percentage by weight: 3.5%-8.5% of an emulsifier, 6%-10% of oil, 9%-15% of a polyol, 0.6%-1% of a thickener, 2%-10% of a composition for preventing and treating chapped skin, and the balance of water; The composition for preventing and treating chapped skin comprises the following components in parts by weight: 0.05-1 part of licorice chalcone A, 0.5-8 parts of tea tree oil, 1-10 parts of lithospermum oil, and 2-15 parts of ophiopogon root extract.

2. The anti-chapped cream according to claim 1, characterized in that The composition comprises the following components in parts by weight: 0.1-0.5 parts of licorice chalcone A, 1-4 parts of tea tree oil, 2-6 parts of lithospermum officinale oil, and 6-10 parts of ophiopogon root extract.

3. The anti-chapped cream according to claim 1, wherein The composition comprises the following components in parts by weight: 0.3 parts of Licorice Chalcone A, 2 parts of Tea Tree Oil, 4 parts of Lithospermum Officinale Oil, and 8 parts of Radix Ophiopogonis Extract.

4. The anti-chapped cream according to claim 1, wherein: At least one of the following (I)-(III) is used: (I) the emulsifier comprises at least one of sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, polyglyceryl-6 esters and cetearyl alcohol; (II) the oil comprises at least one of olive oil, jojoba oil, meadowfoam seed oil, polydimethylsiloxane and cyclopentasiloxane; (III) The thickener comprises at least one of polyacrylate crosspolymer-6, sodium polyacryloyldimethyl taurate and acrylates / C10-30 alkyl acrylate crosspolymer.

5. The anti-chapped cream according to claim 4, characterized in that Adopt at least one of the following (IV)-(VI): (IV) the emulsifier comprises sodium stearoyl lactylate, polyglyceryl-6 esters and cetearyl alcohol; (V) The oils include olive oil, meadowfoam seed oil and polydimethylsiloxane; (VI) The thickener is polyacrylate cross-linked polymer-6.

6. The method for preparing the anti-chapped cream according to claim 1, wherein: The following steps are involved: S1. Heat the oil and emulsifier to 80-85℃ and keep warm for later use; S2. Mix deionized water, polyol and thickener evenly, heat to 85-90°C, and keep warm for 30-35 minutes; S3, adding the mixture of step S1 to the mixture of step S2, stirring evenly and homogenizing for 5-8 minutes; S4, cooling the mixture from step S3 to 40-45° C., then adding the composition for preventing and treating chapped skin, and stirring evenly to obtain the anti-chapped cream.

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