A composition for in-situ hydrogen release, and a method for preparing and using the same

Abstract

The present application relates to a kind of compositions for in situ release of hydrogen and its preparation method and application, composition includes hydrogen release magnesium compound particles, or the combination of hydrogen release magnesium compound particles and organic acid particles, wherein, hydrogen release magnesium compound particles are obtained by the first coating agent coating hydrogen release magnesium compound, and organic acid particles are obtained by the second coating agent coating organic acid.This application prepared with magnesium hydrogen release pill can provide the hydrogen, magnesium content required by human body per day instantaneously, also can provide hydrogen and magnesium in sustained-release mode;It can produce hydrogen, magnesium in vivo instantaneously, also can make magnesium-rich hydrogen water and magnesium-free hydrogen water in any place instantaneously, provide the magnesium-rich hydrogen water or magnesium-free hydrogen water required by human body health care, enhance physical fitness, also can provide instant hydrogen absorption hydrogen source.This magnesium-containing hydrogen release pill can be carried, instantaneously used, and dosage, time, process are safe and controllable.

Description

Technical Field

[0001] This invention relates to the field of materials technology, and in particular to a composition for in-situ hydrogen release, its preparation method, and its application. Background Technology

[0002] Hydrogen is well-known as an effective antioxidant. Due to its strong reducing properties, hydrogen molecules can scavenge harmful free radicals and neutralize excess reactive oxygen species in the body, thus relieving fatigue and delaying aging. Magnesium's health benefits include promoting bone health metabolism, strengthening bones and muscles, preventing osteoporosis, regulating hormone metabolism, regulating energy metabolism, relieving fatigue, and regulating intestinal rhythms.

[0003] Due to the obvious health benefits of hydrogen, a large number of hydrogen-containing products have appeared on the market, such as portable hydrogen storage tanks, hydrogen-rich water, hydrogen water cups, and hydrogen inhalation machines. Because hydrogen is a difficult-to-compress gas, portable hydrogen storage tanks require built-in nano-hydrogen storage materials or high-pressure compression, both of which result in a certain weight and inconvenience for carrying. More importantly, it is difficult to control the amount of hydrogen absorbed by portable hydrogen storage tanks; if a metering system is installed, the "portable" function is completely lost. Furthermore, hydrogen storage tanks pose safety hazards when used in summer. As for "hydrogen-rich water," because hydrogen has very low solubility in water, even if it is forcibly dissolved under high pressure, it is difficult to retain it in water for a long time during storage, so the hydrogen content of hydrogen-rich water products is difficult to guarantee. Hydrogen water cups, in addition to similar problems to hydrogen-rich water, also make it difficult to accurately control the amount of hydrogen produced, thus making it difficult to control daily hydrogen intake; furthermore, the principle of hydrogen water cups is to place magnesium at the bottom of the cup or the lid to produce hydrogen gas, a design that can easily lead to excessive intake of magnesium ions without one's knowledge. In theory, hydrogen inhalation machines can meet various hydrogen inhalation needs, but they are expensive and inconvenient to carry, especially while traveling. Furthermore, based on high-quality health requirements, high-net-worth individuals often inhale hydrogen for half an hour. Calculations show that half an hour of inhalation produces over 4000ml of hydrogen, equivalent to drinking 1400 cups of commercially available hydrogen-rich water or 780 cups of hydrogen water (assuming saturation) (300ml per cup). Therefore, sufficient hydrogen intake cannot be achieved through hydrogen-rich water or hydrogen water cups. Magnesium intake is currently mostly achieved through single supplementation or supplementation with various minerals; magnesium intake through hydrogen water cups is unpredictable. Summary of the Invention

[0004] To address the aforementioned technical problems, this invention provides a capsule that releases hydrogen and magnesium in situ. By coating the hydrogen-releasing magnesium compound or acidic substances separately, it not only solves the problems of effectiveness, safety, controllability, and convenience in practical use of existing portable hydrogen storage tanks, hydrogen-rich water, and hydrogen water cups, as well as the shortcomings of methods that simultaneously achieve hydrogen absorption and supplementation of appropriate amounts of magnesium, but also improves the stability of the capsule, solving the problem of unstable hydrogen release in existing technologies. It simultaneously achieves the controllable release of hydrogen and magnesium, providing a new way to supplement hydrogen in various scenarios such as hydrogen absorption, direct drinking, and ingestion.

[0005] The first object of the present invention is to provide a composition for in-situ hydrogen release, said composition comprising any one of the following:

[0006] (1) Hydrogen-releasing magnesium oxide particles,

[0007] (2) Hydrogen-releasing magnesium compounds and organic acid particles;

[0008] The hydrogen-releasing magnesium compound particles are obtained by coating the hydrogen-releasing magnesium compound with a first coating agent, and the organic acid particles are obtained by coating the organic acid with a second coating agent.

[0009] Furthermore, the first coating agent is selected from one or more of gelatin, polyethylene glycol (such as PEG2000, PEG3000, PEG6000, etc.), and mixtures of polyethylene glycol and inorganic chloride salts. Preferably, it is a mixture of polyethylene glycol 6000 and inorganic chloride salts, which utilizes an appropriate amount of electrolyte in the formula to solve the problem of hydrogen release termination caused by the formation of inorganic coatings on the metal surface during hydrogen release.

[0010] Furthermore, in the mixture of polyethylene glycol and inorganic chloride, the mass ratio of polyethylene glycol to inorganic chloride is >1:1.

[0011] Furthermore, the second coating agent is selected from one or more of carboxymethyl cellulose salt, carboxymethyl starch salt, cross-linked polyvinylpyrrolidone, citric acid / bicarbonate complex, and hydroxypropyl cellulose.

[0012] Furthermore, the hydroxypropyl cellulose has a hydroxypropyl content of no more than 15%.

[0013] Furthermore, the hydrogen-releasing magnesium compound is selected from one or more of metallic magnesium, magnesium alloys, or magnesium compounds.

[0014] Furthermore, the particle size of the hydrogen-releasing magnesium compound is 20-200 μm, with a preferred particle size range of 50-100 μm. By controlling the particle size of the hydrogen-releasing magnesium compound and utilizing the disintegration rate of the coating material in the working environment, slow hydrogen release in the application scenario can be achieved.

[0015] Furthermore, the organic acid is selected from one or more of citric acid, malic acid, tartaric acid, and fumaric acid.

[0016] Furthermore, the above composition may or may not contain edible or biocompatible components and may be formulated into compound pellets, tablets, or capsules. These edible components may be starch and starch derivatives, edible gums, etc.; these biocompatible components may be biodegradable polymers or polymeric excipients, or biocompatible oligomers, polymers, amphiphilic biomaterials, etc., that can be safely excreted from the body. Examples include fillers, lubricants, flavorings, vitamins, etc.

[0017] Further, based on a mass percentage of 100%, the composition of the components is as follows: 0.05-40% magnesium hydrogen-releasing compound, 0-50% organic acid, 1-10% first coating agent, 1-10% second coating agent, 0-80% filler, 0-5% lubricant, 0-5% flavoring agent, and 0-5% vitamin. Preferably, based on a total capsule weight of 100%, the proportions of each component are as follows: 1-40% magnesium hydrogen-releasing compound, 5-45% organic acid, 4-10% first coating agent, 3-6% second coating agent, 50-80% filler, 0-4% lubricant, 0.04-1% flavoring agent, and 4-5% vitamin.

[0018] Furthermore, the filler includes, but is not limited to, any one or more combinations of lactose, starch, cellulose, silica particles, chitin, calcium carbonate, etc.

[0019] Furthermore, vitamins include, but are not limited to, any one or more combinations of vitamins A, B1, B2, B3, B5, B6, B7, B9, B12, C, D, E, and K.

[0020] Furthermore, the lubricant includes, but is not limited to, any one or more combinations of polyoxyethylene monostearate, polyoxyethylene lauryl ether, poloxamer, boric acid, sodium benzoate, sodium acetate, sodium chloride, sodium stearate, magnesium stearate, DL-leucine, sodium lauryl sulfate, magnesium lauryl sulfate, polyethylene glycol 4000 or 6000, etc.

[0021] Furthermore, the flavoring agents include, but are not limited to, one or more combinations of stevia, disodium glycyrrhizate, acesulfame potassium, erythritol, aspartame, cyclamate, sodium saccharin, and sucralose.

[0022] A second object of the present invention is to provide a method for preparing the above-mentioned hydrogen-releasing composition. The composition can be prepared by various physical methods, and the present invention only provides one such method for reference. The preparation method includes the following steps:

[0023] The first coating agent is softened or melted at a temperature slightly above its softening point, generally above 50°C, and more often between 70-90°C. The hydrogen-releasing magnesium compound is ground under a protective atmosphere and added to the first coating agent. The mixture is then kneaded or mixed until homogeneous to obtain the composition.

[0024] Furthermore, when the composition does not contain organic acid particles, a composition including hydrogen-releasing magnesium compounds can be prepared by direct granulation.

[0025] Furthermore, when the composition contains organic acid particles, the organic acid and the second coating agent can be prepared into organic acid particles using various physical methods such as co-milling, blending, or coating. Examples of such methods are, but are not limited to:

[0026] S1. The composition including the hydrogen-releasing magnesium oxide particles is cooled and then ground again to form particles;

[0027] S2. The ground solid organic acid is mixed with the second coating agent solution and dried to obtain organic acid particles;

[0028] S3. Mix the hydrogen-releasing magnesium oxide particles and the organic acid particles obtained in S2 to obtain the composition.

[0029] Furthermore, the above preparation method also includes a step of grinding and then sieving.

[0030] Furthermore, step S2 also includes the step of weighing the adjuvants according to the formula and mixing them with the magnesium hydrogen-releasing compound particles and organic acid particles to prepare different dosage forms.

[0031] Furthermore, the magnesium metal, magnesium alloy, or magnesium compound therein is in granular or powder form. Depending on the application scenario and the object of application, the particle size can vary, generally less than 1 mm, preferably less than 0.1 mm, and even more preferably less than 50 micrometers.

[0032] Furthermore,

[0033] Furthermore, the above composition can be granulated into any possible geometric shape, such as spheres, capsules, or tablets; there are no strict limitations on the size of such capsules, pills, or tablets. Generally, they are no larger than 20 mm square, preferably within 10 mm, and each capsule generally contains less than 1000 mg of metal catalyst. Different dosages can be designed according to the user's gender, age, pregnancy status, etc.

[0034] Furthermore, depending on the application scenario (direct swallowing, drinking with water, or hydrogen inhalation), the dosage of each tablet or pill can be different, but generally the magnesium content is: preferably less than 1000 mg for hydrogen inhalation, preferably less than 500 mg for drinking with water, and preferably less than 300 mg for swallowing.

[0035] Most preferably, the above composition is made into capsules. The bidirectional coating material of the magnesium hydrogen ion oxide particles and the acidic substance can achieve amphiphilic fusion between different excipients. Under the dry storage environment, sufficient cohesion is formed inside the drug, which is more conducive to the preparation of dosage form and stable storage, and avoids moisture absorption.

[0036] A third objective of this invention is to provide the application of the aforementioned hydrogen-releasing composition in hydrogen release, such as in the preparation of in vivo or in vitro hydrogen-releasing materials. The magnesium-containing hydrogen-releasing pills of this invention can release hydrogen and magnesium in situ and quantitatively upon contact with water. They can be taken directly with warm water to generate in situ hydrogen and release magnesium ions in the body; they can also generate magnesium-rich hydrogen water in situ in vitro for immediate consumption; or generate hydrogen in situ in vitro to provide an immediate hydrogen source for hydrogen absorption.

[0037] By means of the above-described solution, the present invention has at least the following advantages:

[0038] (1) The present invention uses an in-situ controllable hydrogen release method to avoid the use of high-pressure hydrogen charging process, while the controllable dosage of hydrogen source provides great convenience for various use scenarios (hydrogen inhalation, direct drinking or swallowing).

[0039] (2) The present invention uses different materials to coat the hydrogen-releasing magnesium compounds and acidic substances, which prevents the oxidation of active magnesium compounds in the air during preparation and storage, and the possible reactions between them and other components, thus overcoming the instability problem in the existing patented technology.

[0040] The above description is merely an overview of the technical solution of the present invention. In order to better understand the technical means of the present invention and to implement it in accordance with the contents of the specification, the preferred embodiments of the present invention are described below. Detailed Implementation

[0041] The present invention will be further described below with reference to specific embodiments, so that those skilled in the art can better understand and implement the present invention, but the embodiments are not intended to limit the present invention.

[0042] Example 1

[0043] The preparation method of the capsules that release hydrogen and magnesium in situ in this embodiment is as follows:

[0044] (1) Under nitrogen protection, 40 parts by weight of hydrogen-releasing magnesium compound were placed in a ball mill and ground thoroughly under nitrogen protection to obtain approximately 80 mesh hydrogen-releasing magnesium compound particles, which were then stored under an inert gas.

[0045] (2) Mix and melt 6 parts by weight of PEG6000 and 4 parts by weight of magnesium chloride at 80°C. Add the hydrogen-releasing magnesium oxide particles under nitrogen protection. After stirring and mixing thoroughly and cooling to solidify, grind the resulting coated particles through a 60-mesh sieve to obtain hydrogen-releasing magnesium oxide coated particles.

[0046] (3) Weigh 45 parts by weight of malic acid solid, grind it thoroughly in a ball mill, pass the resulting powder through a 100-sieve, spray it into a cross-linked polyvinylpyrrolidone ethanol solution containing 5 parts by weight, and vacuum dry it to obtain organic acid cross-linked polyvinylpyrrolidone composite particles.

[0047] (4) The hydrogen-releasing magnesium compound-coated particles and the organic acid cross-linked polyvinylpyrrolidone composite particles are uniformly mixed and then compressed into tablets to obtain capsules that release hydrogen and magnesium in situ.

[0048] Example 2

[0049] The preparation method of the capsules that release hydrogen and magnesium in situ in this embodiment is as follows:

[0050] (1) Under nitrogen protection, 40 parts by weight of hydrogen-releasing magnesium compound were placed in a ball mill and ground thoroughly. The resulting powder was then passed through an 80-sieve under nitrogen protection to obtain uniform hydrogen-releasing magnesium compound particles, which were then stored under an inert gas.

[0051] (2) Melt 10 parts by weight of PEG6000 at 80°C, add hydrogen-releasing magnesium oxide particles under nitrogen protection, stir and mix thoroughly until uniform, cool and solidify, and then grind. The resulting coated particles are passed through a 60-mesh sieve to obtain hydrogen-releasing magnesium oxide coated particles.

[0052] (3) Weigh 45 parts by weight of malic acid solid, grind it thoroughly in a ball mill, pass the resulting powder through a 100-sieve, spray it into a cross-linked polyvinylpyrrolidone ethanol solution containing 5 parts by weight, and vacuum dry it to obtain organic acid cross-linked polyvinylpyrrolidone composite particles.

[0053] (4) The hydrogen-releasing magnesium compound-coated particles and the organic acid cross-linked polyvinylpyrrolidone composite particles are uniformly mixed and then compressed into tablets to obtain capsules that release hydrogen and magnesium in situ.

[0054] Example 3

[0055] The preparation method of the capsules that release hydrogen and magnesium in situ in this embodiment is as follows:

[0056] (1) Under nitrogen protection, 40 parts by weight of hydrogen-releasing magnesium compound were placed in a ball mill and ground thoroughly. The resulting powder was passed through an 80-sieve under nitrogen protection to obtain uniform hydrogen-releasing magnesium compound particles, which were then stored under an inert gas.

[0057] (2) Melt 10 parts by weight of gelatin at 80°C, add hydrogen-releasing magnesium oxide particles under nitrogen protection, stir and mix thoroughly until uniform, cool and solidify, and then grind. The resulting coated particles are passed through a 60-mesh sieve to obtain hydrogen-releasing magnesium oxide coated particles.

[0058] (3) Weigh 45 parts by weight of malic acid solid, grind it thoroughly in a ball mill, pass the resulting powder through a 100-sieve, spray it into a cross-linked polyvinylpyrrolidone ethanol solution containing 5 parts by weight, and vacuum dry it to obtain organic acid cross-linked polyvinylpyrrolidone composite particles.

[0059] (4) The hydrogen-releasing magnesium compound-coated particles and the organic acid cross-linked polyvinylpyrrolidone composite particles are uniformly mixed and then compressed into tablets to obtain capsules that release hydrogen and magnesium in situ.

[0060] Example 4

[0061] The preparation method of the capsules that release hydrogen and magnesium in situ in this embodiment is as follows:

[0062] (1) Under nitrogen protection, 40 parts by weight of hydrogen-releasing magnesium compound were placed in a ball mill and ground thoroughly. The resulting powder was passed through an 80-sieve under nitrogen protection to obtain uniform hydrogen-releasing magnesium compound particles, which were then stored under an inert gas.

[0063] (2) Mix and melt 6 parts by weight of PEG6000 and 4 parts by weight of sodium chloride at 80°C. Add the hydrogen-releasing magnesium oxide particles under nitrogen protection. After stirring and mixing thoroughly and cooling to solidify, grind the resulting coated particles through a 60-mesh sieve to obtain hydrogen-releasing magnesium oxide coated particles.

[0064] (3) Weigh 45 parts by weight of solid citric acid, grind it thoroughly in a ball mill, pass the resulting powder through a 100-sieve, spray it into a solution containing 5 parts by weight of sodium carboxymethyl starch, and dry it under vacuum to obtain organic acid sodium carboxymethyl starch composite particles.

[0065] (4) The hydrogen-releasing magnesium compound-coated particles and the organic acid carboxymethyl starch sodium composite particles are uniformly mixed and then compressed into tablets to obtain capsules that release hydrogen and magnesium in situ.

[0066] Example 5

[0067] The preparation method of the capsules that release hydrogen and magnesium in situ in this embodiment is as follows:

[0068] (1) Five parts by weight of hydrogen-releasing magnesium compound (magnesium alloy) were placed in a ball mill and ground thoroughly under nitrogen protection. The resulting powder was then passed through a 100-sieve under nitrogen protection to obtain uniform hydrogen-releasing magnesium compound particles, which were then stored under an inert gas.

[0069] (2) Mix and melt 2 parts by mass of PEG6000 and 2 parts by mass of sodium chloride at 90°C. Add the hydrogen-releasing magnesium oxide particles under nitrogen protection. After stirring and mixing thoroughly and cooling to solidify, grind the resulting coated particles through an 80-mesh sieve to obtain hydrogen-releasing magnesium oxide coated particles.

[0070] (3) Weigh 20 parts of tartaric acid solid according to the formula, grind it thoroughly in a ball mill, pass the resulting powder through a 100-sieve, spray it into an ethanol solution containing 6 parts by weight of cross-linked polyvinylpyrrolidone, and vacuum dry it to obtain organic acid cross-linked polyvinylpyrrolidone composite particles.

[0071] (4) Weigh 57 parts by weight of lactose, 4 parts by weight of vitamin B2, and 4 parts by weight of magnesium stearate according to the formula. After mixing and grinding thoroughly, add the hydrogen-releasing magnesium compound coated particles and the organic acid cross-linked polyvinylpyrrolidone composite particles. After uniform mixing, compress the mixture to obtain capsules that release hydrogen and magnesium in situ.

[0072] Example 6

[0073] The preparation method of the capsules that release hydrogen and magnesium in situ in this embodiment is as follows:

[0074] (1) Under nitrogen protection, 1 part by weight of hydrogen-releasing magnesium compound (magnesium compound) was placed in a ball mill and ground thoroughly. Under nitrogen protection, the resulting powder was passed through a 100-sieve to obtain uniform hydrogen-releasing magnesium compound particles, which were then stored under an inert gas.

[0075] (2) Mix and melt 2 parts by mass of PEG6000 and 2 parts by mass of sodium chloride at 70°C. Add the hydrogen-releasing magnesium oxide particles under nitrogen protection. After stirring and mixing thoroughly and cooling to solidify, grind the resulting coated particles through an 80-mesh sieve to obtain hydrogen-releasing magnesium oxide coated particles.

[0076] (3) Weigh 5 parts of fumaric acid solid according to the formula, grind it thoroughly in a ball mill, pass the resulting powder through a 100-sieve, spray it into a solution containing 3 parts by weight of sodium carboxymethyl cellulose, and vacuum dry it to obtain organic acid sodium carboxymethyl cellulose composite particles.

[0077] (4) Weigh 79 parts by weight of lactose, 4 parts by weight of vitamin B2, and 4 parts by weight of magnesium stearate according to the formula. After mixing and grinding thoroughly, add the hydrogen-releasing magnesium compound coated particles and organic acid carboxymethyl cellulose sodium composite particles. After uniform mixing, compress into tablets to obtain capsules that release hydrogen and magnesium in situ.

[0078] Example 7

[0079] The preparation method of the sustained-release magnesium hydrogen phosphate pellets in this embodiment is as follows:

[0080] (1) Under nitrogen protection, 1 part by weight of hydrogen-releasing magnesium compound (magnesium compound) was placed in a ball mill and ground thoroughly. Under nitrogen protection, the resulting powder was passed through a 100-sieve to obtain uniform hydrogen-releasing magnesium compound particles, which were then stored under an inert gas.

[0081] (2) Mix and melt 2 parts by weight of PEG6000 and 2 parts by weight of magnesium chloride at 70°C. Add the hydrogen-releasing magnesium oxide particles under nitrogen protection. After stirring and mixing thoroughly and cooling to solidify, grind the resulting coated particles through an 80-mesh sieve to obtain hydrogen-releasing magnesium oxide coated particles.

[0082] Comparative Example

[0083] Replace 6 parts by weight of PEG6000 and 4 parts by weight of sodium chloride with 10 parts by weight of lactose or other polysaccharides, and the rest is the same as in Example 1.

[0084] Test case

[0085] (1) Immediate hydrogen generation for breathing mode: This test case is for on-site hydrogen generation for breathing, so the capsules prepared in Example 1 were used for testing. The main components of the modified formulation in Example 1 are hydrogen-releasing materials and excipients that control the hydrogen release rate, including coating agents that maintain product stability during preparation and storage and salts and organic acids that promote hydrogen release.

[0086] The results showed that each capsule weighs 2 grams. When used with a breathing device, each capsule can provide one adult with 15 minutes of breathing time, with an average total airflow velocity of 75 ml / s and a hydrogen content of 1.1%, equivalent to a hydrogen flow rate of 0.83 ml / s. Depending on the hydrogen inhalation requirements, multiple capsules can be used daily.

[0087] (2) Hydrogen-rich drinking water mode with slow-release hydrogen: This test case is for on-site generation of hydrogen-rich water for drinking. Therefore, the capsules prepared in Example 5 were used for testing. The proportion of hydrogen-releasing materials in the formula was reduced. Hydrogen-releasing magnesium compounds and organic acid components were bidirectionally coated to maintain product stability during preparation and storage. At the same time, healthy vitamin components were added.

[0088] The results showed that each capsule weighing 1 gram, when added to 300 ml of room temperature drinking water, released 43 ml of pure hydrogen within 10 minutes. The amount of hydrogen produced was equivalent to the hydrogen content of 26 cups of ordinary hydrogen-rich water, making it safe to drink directly.

[0089] (3) Sustained-release hydrogen tablet swallowing mode:

[0090] This test case is for oral administration. The capsules prepared in Example 6 directly generate a small amount of hydrogen gas in the body. The proportion of hydrogen-releasing materials and organic acids in the formula is reduced. The hydrogen-releasing magnesium compound and organic acid components are bidirectionally coated to maintain product stability during preparation and storage. At the same time, health-beneficial vitamin components are added.

[0091] The results showed that each capsule, weighing 1 gram, when swallowed directly with warm water, releases 9 ml of pure hydrogen within 10 minutes, equivalent to the hydrogen content of 5.5 cups of commercially available hydrogen-rich water.

[0092] The sustained-release magnesium hydrogen capsules prepared in Example 7 do not contain any organic acids and can be taken directly for hydrogen release in the body. When swallowed, due to body temperature and gastric acid, a certain amount of hydrogen gas can be generated even without the addition of external acid; the amount of hydrogen gas produced is determined by the amount of magnesium used. Therefore, the magnesium hydrogen-releasing capsules of this invention can be prepared according to the needs of different situations, not only providing a quantitative supply of hydrogen gas but also ensuring long-term stable storage.

[0093] (4) The hydrogen production of the tablets of Example 1 and the comparative example was measured after being placed at room temperature for 1 week to 3 months and compared with the hydrogen production of the newly prepared tablets.

[0094] The results showed that after one week of storage, the hydrogen production of tablets prepared with different polysaccharide ratios decreased by at least 30% compared to newly prepared tablets, while the hydrogen production of tablets prepared in Example 1 did not decrease significantly even after 3 months of storage.

[0095] (5) The tablets prepared in Examples 1-4 were respectively added to 100 ml of pure water, and the hydrogen release rate and release amount were obtained as follows:

[0096] Table 1 Hydrogen release of tablets under different formulations

[0097]

[0098] The results showed that in Example 1, the tablets disintegrated rapidly, the hydrogen release reaction started quickly, and the hydrogen release rate was uniform; in Example 2, the hydrogen release process started slowly and the hydrogen release was uneven; in Example 3, the tablets disintegrated slowly and the hydrogen release rate was slow; and in Example 4, the tablets disintegrated slowly and the hydrogen release rate was uneven.

[0099] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of this invention.

Claims

1. A composition for in-situ hydrogen release, characterized in that, The composition comprises hydrogen-releasing magnesium oxide particles and organic acid particles; The hydrogen-releasing magnesium compound particles are obtained by coating the hydrogen-releasing magnesium compound with a first coating agent, and the organic acid particles are obtained by coating the organic acid with a second coating agent. The first coating agent is selected from one or more of gelatin, polyethylene glycol and inorganic chloride salts; the second coating agent is selected from one or more of carboxymethyl cellulose salt and cross-linked polyvinylpyrrolidone; the hydrogen-releasing magnesium compound is selected from one or more of metallic magnesium and magnesium alloys; and the organic acid is selected from one or more of malic acid, tartaric acid and fumaric acid.

2. The composition according to claim 1, characterized in that, The composition also includes one or more of the following additives: fillers, lubricants, flavoring agents, and vitamins.

3. The composition according to claim 2, characterized in that, The composition of the composition, by weight percentage (100%), comprises: 1-40% magnesium hydrogen sulfide, 5-45% organic acid, 4-10% first coating agent, 3-6% second coating agent, 50-80% filler, 0-4% lubricant, 0.04-1% flavoring agent, and 4-5% vitamins.

4. A method for preparing the composition according to any one of claims 1-3, characterized in that, Includes the following steps: S1. Soften or melt the first coating agent at a temperature above its softening point, grind the hydrogen-releasing magnesium compound under a protective atmosphere, add it to the softened or melted first coating agent, and knead or mix until homogeneous to obtain the composition. S2. After cooling the composition in S1, grind it again to form particles; S3. Mix the ground solid organic acid with the second coating agent solution, and dry to obtain organic acid particles; S4. Mix the particles obtained from S2 and S3 to obtain a composition comprising magnesium hydrogen-releasing particles and organic acid particles.

5. The composition for in-situ hydrogen release according to any one of claims 1-3, characterized in that, The hydrogen-releasing composition can be granulated into any shape.

6. The composition according to claim 5, characterized in that, The shape includes tablets or pills of various geometric shapes.

7. Use of the composition according to any one of claims 1-3 in the preparation of hydrogen-releasing products.

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