A suspension concentrate containing fluazinam and cyazofamid and preparation method thereof

Abstract

The present invention relates to the field of pesticide technology, and more particularly to a suspension concentrate containing fluazinam and cyazofamid and a preparation method thereof. The suspension concentrate comprises an active ingredient, a dispersant, a wetting agent, a thickener, a defoamer, an antifreeze agent, a preservative, and water; the active ingredients are composed of fluazinam and cyazofamid. The present invention greatly reduces the processing difficulty of the dosage form and improves the stability of the dosage form. It has the advantages of good water dispersibility and high suspension rate. Without the addition of anti-decomposition factors, it effectively solves the problems of sample storage stratification, solidification, particle size growth, discoloration, and content degradation.

Description

Technical Field

[0001] The present invention relates to the technical field of pesticides, and in particular to a suspension concentrate containing fluazinam and cyazofamid and a preparation method thereof. Background Art

[0002] Fluazinam, chemical name: 3-chloro-N-(3-chloro-2,6-dinitro-4-trifluoromethylphenyl)-5-trifluoromethyl-2-pyridinamine, is a pyridinamine derivative and a dinitroaniline fungicide. It is mainly used to prevent and control downy mildew, gray mold, sclerotinia, anthracnose on vegetables and scab, anthracnose, black spot and other diseases on fruit trees; and it has a more prominent preventive effect on blight, clubroot and gray mold.

[0003] Cyazofamid (Cyazofamid), chemical name: 4-chloro-2-cyano-5-p-methylphenyl-imidazole-1-N,N-dimethylsulfonamide, belongs to the sulfaimidazole fungicide class and is mainly used to prevent and control oomycete diseases such as downy mildew, downy mildew, blight, late blight, etc.; it can be applied to a variety of plants such as potatoes, tomatoes, peppers, cucumbers, melons, cabbage, lettuce, onions, grapes, and lychees.

[0004] Fungicides containing a single active ingredient often suffer from varying degrees of deficiencies in agricultural fungicide control, such as a narrow fungicide range, poor control effectiveness, high application doses that can easily lead to resistance, and frequent applications that increase environmental pollution. One approach to combating resistant agricultural pathogens is to develop new active ingredients that lack cross-resistance with existing varieties. However, the development of new active ingredients is costly and time-consuming, and often cannot keep pace with the rate of resistance development. Other approaches, such as adjusting crop placement and rotating different pesticides, rarely achieve significant results in practice. Combining different active ingredients is the most common method for combating resistant pathogens. Combining different active ingredients can improve control effectiveness, expand the fungicide range, reduce active ingredient dosage, save pesticide costs, and reduce environmental pollution, making it an important tool for comprehensive field disease control.

[0005] The current domestically available close technology CN103563948A patent has disclosed a compound composition of fluazinam and cyazofamid. This patented composition involves a first active component, cyazofamid, and a second active component, one of pyraclostrobin, fluazinam, dimethomorph, cymoxanil, benzathiapyr, zoxamide, or famoxadone. It mainly introduces a fungicide composition containing cyazofamid and the application of its related dosage forms, proves the synergistic effect between the active components in the composition, and solves the problem of component decomposition.

[0006] However, existing fluazinam / cyazofamid suspensions suffer from poor physical stability and are easily affected by environmental changes during storage and transportation, leading to agglomeration, stratification, particle growth, and water precipitation, which seriously impact their efficacy. Their components are also susceptible to decomposition and discoloration due to factors such as pH. Furthermore, their use is significantly affected by varying water quality, such as intolerance to 3 WHO-specified water, hindering their use and promotion. Summary of the Invention

[0007] In view of this, the present invention provides a suspension concentrate containing fluazinam and cyazofamid and a preparation method thereof. This invention solves the problems of decomposition of the active ingredients and discoloration of the appearance.

[0008] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0009] The invention provides a suspension containing fluazinam and cyazofamid. The suspension comprises an active ingredient, a dispersant, a wetting agent, a thickener, a defoaming agent, an antifreeze agent, a preservative and water; the active ingredient consists of fluazinam and cyazofamid.

[0010] Preferably, the amount of each component is as follows in percentage by mass:

[0011]

[0012] Among the active ingredients, the mass ratio of fluazinam to cyazofamid is (1-6):1.

[0013] The fluazinam-cyazofamid suspension concentrate provided by the present invention overcomes the disadvantage of rapid development of cyazofamid resistance, and the two active ingredients have a synergistic effect, which is beneficial for reducing dosage and application frequency. The present invention improves product stability by optimizing auxiliary agents, and can withstand high and low temperature ranges of -15°C to 65°C, effectively solving the adverse effects that may be caused by environmental changes during transportation, and avoiding product quality problems such as caking, delamination, particle size growth, and water precipitation. Moreover, without adding anti-decomposition factors, through the rational combination of auxiliary agents, the pH of the product is controlled within a reasonable range on the basis of solving the above-mentioned physical stability of the product, thereby solving the problems of component decomposition and appearance discoloration. At the same time, the present invention can tolerate different water qualities such as C water, D water, and 3 WHO water, meeting the use requirements of different countries and regions, and facilitating large-scale promotion and application.

[0014] Preferably, the composition comprises the following components in percentage by mass:

[0015]

[0016] Preferably, the following components are included in percentage by mass:

[0017]

[0018] Preferably, the dispersant is at least one of lignin sulfonate, naphthalene sulfonate formaldehyde condensate, styrene acrylic acid copolymer sodium salt, alkylphenol polyoxyethylene ether sulfonate, alkylphenol polyoxyethylene ether phosphate, styrene maleic anhydride acrylate polymer ammonium salt, formaldehyde cresol sulfonic acid sodium salt or styrene maleic anhydride copolymer sodium salt.

[0019] The above-mentioned lignin sulfonate is preferably sodium lignin sulfonate.

[0020] The above-mentioned alkylphenol polyoxyethylene ether sulfonate is preferably sodium dodecylphenol polyoxyethylene ether sulfonate.

[0021] The alkylphenol polyoxyethylene ether phosphate is preferably octylphenol polyoxyethylene ether sodium phosphate.

[0022] Preferably, the wetting agent is at least one of tristyrylphenol polyoxyethylene ether sulfate ammonium salt, maleic rosin block polyether sulfonic acid ammonium salt, fatty alcohol polyoxyethylene ether phosphate, alkyl succinic acid sulfonate, alkylphenol polyoxyethylene ether sulfate, propylene oxide-ethylene oxide block polyether or castor oil polyoxyethylene ether phosphate.

[0023] The fatty alcohol polyoxyethylene ether phosphate is preferably lauryl alcohol polyoxyethylene ether phosphate.

[0024] The alkyl succinic acid sulfonate is preferably sodium dodecyl succinic acid sulfonate.

[0025] The alkylphenol polyoxyethylene ether sulfate is preferably octylphenol polyoxyethylene ether sulfate sodium salt.

[0026] Preferably, the dispersant is at least one of naphthalenesulfonate formaldehyde condensate, styrene acrylic acid copolymer sodium salt or styrene maleic anhydride copolymer sodium salt;

[0027] The wetting agent is at least one of tristyrylphenol polyoxyethylene ether sulfate ammonium salt, propylene oxide-ethylene oxide block polyether or maleated rosin block polyether sulfonic acid ammonium salt.

[0028] More preferably, the dispersant is a combination of two dispersants, consisting of a first dispersant and a second dispersant; and the wetting agent is one wetting agent.

[0029] Preferably, the mass ratio of the first dispersant, the second dispersant, and the wetting agent is (1-5):(1-5):(1-5). A further preferred mass ratio is (1-3):(1-3):(1-3). A further preferred mass ratio is (1-3):2:(2-3). In a specific embodiment provided by the present invention, the mass ratio is 1:1:1.

[0030] In some specific embodiments of the present invention, the mass contents of the first dispersant, the second dispersant, and the wetting agent are 1% to 2%, 1% to 2%, and 1% to 3%, respectively. Specifically, they can be 1%, 2%, 1%, or 2%, 2%, 3%, or 1%, 2%, 2%, or 2%, 2%, 2%, or a range value with any of the above specific values ​​as the upper or lower limit, and most preferably are 2%, 2%, and 2%.

[0031] The first dispersant and the second dispersant are preferably a mixture of any two of naphthalenesulfonate formaldehyde condensate, styrene acrylic acid copolymer sodium salt or styrene maleic anhydride copolymer sodium salt.

[0032] The wetting agent is one of tristyrylphenol polyoxyethylene ether sulfate ammonium salt, propylene oxide-ethylene oxide block polyether or maleated rosin block polyether sulfonic acid ammonium salt.

[0033] Preferably, the thickener is at least one of ordinary white carbon black, magnesium aluminum silicate, methyl cellulose, organic bentonite, xanthan gum or sodium polyacrylate.

[0034] Preferably, the thickener is at least one of ordinary white carbon black, magnesium aluminum silicate, organic bentonite, and xanthan gum.

[0035] The thickener is further preferably two of ordinary white carbon black, magnesium aluminum silicate, organic bentonite, and xanthan gum.

[0036] The thickener is more preferably a mixture of xanthan gum and magnesium aluminum silicate. Preferably, the mass ratio of xanthan gum to magnesium aluminum silicate is 1:1-6. More preferably, the mass ratio is 1:2-5. More preferably, the mass ratio is 1:3-5. More preferably, the mass ratio is 1:3.33.

[0037] In some specific embodiments of the present invention, the mass contents of xanthan gum and magnesium aluminum silicate are 0.15%, 2%, or 0.15%, 0.5%, or 0.15%, 3%, or range values ​​with any of the above specific values ​​as the upper or lower limit, and most preferably are 0.15% and 0.5%.

[0038] Preferably, the antifreeze agent is at least one of urea, potassium chloride, ethylene glycol, propylene glycol, glycerol, polyethylene glycol, sorbitol or sodium chloride.

[0039] Furthermore, the antifreeze agent is preferably ethylene glycol.

[0040] Preferably, the mass percentage of ethylene glycol in the suspending agent is preferably 2% to 20%, specifically 2%, 4%, 5%, 10%, 15%, 20%, or a range value with any of the above specific values ​​as the upper or lower limit; most preferably 5% or 10%.

[0041] Preferably, the preservative is at least one of kason, paraformaldehyde and sodium benzoate.

[0042] Furthermore, the preservative is preferably kason.

[0043] Preferably, the mass percentage of kasonide in the suspending agent is 0.1% to 2%, specifically 0.1%, 0.2%, 0.3%, 0.5%, 1%, 2%, or a range value with any of the above specific values ​​as the upper or lower limit, and most preferably 0.1%.

[0044] Preferably, the defoaming agent is at least one of a polyether defoaming agent, a silicone defoaming agent or a polyether-modified polysiloxane defoaming agent.

[0045] Furthermore, the defoaming agent is preferably a silicone defoaming agent.

[0046] Preferably, the mass percentage of the silicone defoaming agent in the suspending agent is preferably 0.2% to 3%, specifically 0.2%, 0.3%, 0.5%, 1%, 2%, 3%, or a range value with any of the above specific values ​​as the upper or lower limit, and most preferably 0.2%.

[0047] The present invention also provides a method for preparing the above-mentioned suspension concentrate, which comprises the following steps: mixing water, a dispersant, a wetting agent and a preservative, adding a thickener, a defoamer, an antifreeze agent, cyazofamid and fluazinam under high-speed shearing conditions, shearing for 10 to 30 minutes, and then grinding until the particle size D90 of the mixture is less than 7 μm to obtain a suspension concentrate containing fluazinam and cyazofamid.

[0048] Preferably, the rotation speed of the high-speed shearing is 1000 to 10000 r / min.

[0049] In a specific embodiment provided by the present invention, the thickener is xanthan gum and magnesium aluminum silicate. In order to reduce the difficulty of frosting, the preparation method adopted by the present invention comprises: mixing water, a dispersant, a wetting agent, a preservative, a portion of a defoaming agent, and a portion of an antifreeze; adding the thickener (magnesium aluminum silicate), cyazofamid, and fluazinam under high-speed shearing conditions; shearing for 10 to 30 minutes; and then grinding until the particle size D90 of the mixture is less than 7 μm; adding the remaining defoaming agent, thickener (xanthan gum), and the remaining antifreeze under high-speed shearing conditions; shearing for 10 to 30 minutes to obtain a suspension containing fluazinam and cyazofamid.

[0050] In the above preparation method, grinding can be performed by any grinding method disclosed in the prior art, for example, grinding can be performed under zirconia bead grinding media. After grinding, the particles are measured using a laser particle size distribution analyzer until the particle size D90 is less than 7 μm.

[0051] The present invention has the following beneficial effects:

[0052] 1) The pesticide composition provided by the present invention makes up for the disadvantage of the rapid development of resistance to a single agent of cyazofamid, and the two active components have a synergistic effect, delaying the development of resistance, reducing the amount and frequency of application, and thus reducing the cost of the agent.

[0053] 2) The inventors conducted extensive screening of the auxiliary agent system and ultimately arrived at a system with the best matching degree between the above-mentioned components, especially the screening and combination of the three components of dispersant, wetting agent and thickener. This greatly reduced the processing difficulty of the dosage form and improved the stability of the dosage form. It has the advantages of good water dispersibility and high suspension rate. Without adding anti-decomposition factors, it effectively solved the problems of sample storage stratification, solidification, particle size growth, discoloration, and content degradation.

[0054] 3) Based on 2), while ensuring physical stability, there is no need to add antioxidants, pH regulators and other anti-decomposition factors. By rationally matching the additives, the product can be kept within a reasonable pH range, thus solving the problems of component decomposition and discoloration. DETAILED DESCRIPTION

[0055] The present invention discloses a suspension containing fluazinam and cyazofamid and a method for preparing the same. Those skilled in the art can refer to the contents of this article and appropriately improve the process parameters. It should be noted that all similar replacements and modifications are obvious to those skilled in the art and are considered to be included in the present invention. The methods and applications of the present invention have been described through preferred embodiments, and relevant personnel can obviously modify or appropriately change and combine the methods and applications described herein without departing from the content, spirit and scope of the present invention to implement and apply the technology of the present invention.

[0056] The present invention provides a suspension concentrate containing fluazinam and cyazofamid, wherein:

[0057] Fluazinam: The original drug has a molecular weight of 465.09 and appears as yellow crystals. The melting point is 115-117°C, the relative density is 1.757 (20°C), and the vapor pressure is 1.47×10 -3 Pa (25°C), logP = 3.56 (25°C). Solubility in water at 25°C: 0.1 mg / L (pH = 5.0), 1.7 mg / L (pH = 6.8), >1000 mg / L (pH = 11). Easily hydrolyzes and changes color under alkaline conditions.

[0058] Cyazofamid: The technical product is a light yellow powdery solid. Molecular weight: 342.79; melting point: 152.7°C; relative density: 1.446; water solubility: 0.107 mg / L (pH = 7, 20°C); vapor pressure: <1.33×10 -5Pa; log P value is 3.2 (25℃); slightly soluble in (n-)hexane, n-octanol, toluene, and methanol, soluble in dichloroethane, acetonitrile, ethyl acetate, and acetone; hydrolyzes under alkaline conditions and is photolabile.

[0059] Judging from the properties of the two, the components are sensitive to pH and are prone to decomposition and discoloration. This problem can be solved by screening the combination of additives. Due to the large specific gravity of the original drug and the high content of the composition, it is difficult to mix the two active ingredients to make an aqueous suspension concentrate. The original drug particles have sedimentation, solidification, and bottoming problems in the suspended dispersion system. The introduction of white carbon black or magnesium aluminum silicate can be considered to improve the stability of the system structure and avoid sedimentation and bottoming problems.

[0060] Chinese and English names of active ingredients and some excipients:

[0061]

[0062] Unless otherwise specified, the following percentages are all by weight.

[0063] The raw materials and auxiliary agents used in the present invention can be purchased from the market.

[0064] The present invention will be further described below in conjunction with the embodiments:

[0065] Examples 1 to 9, Comparative Examples 1 to 4

[0066] The formulas of various embodiments and comparative examples are as follows:

[0067] Table 1

[0068]

[0069]

[0070] Preparation method: water, dispersant, wetting agent and preservative are added to the feeding kettle, mixed and dispersed evenly, and then thickener, defoamer, antifreeze, cyazofamid and fluazinam are added to the feeding kettle under a high-speed shearing state of 1000-10000 r / min. The material is sheared for 10 to 30 minutes, and then the material is ground under a zirconium oxide bead sand mill medium until the particle size D90 of the mixture is less than 7 μm to obtain a suspension containing fluazinam and cyazofamid.

[0071] Test Example 1 Performance Test

[0072] The properties of the aqueous suspension concentrates prepared in the above examples and comparative examples were tested, and the results are shown in Table 2 below. The suspension rate was tested according to the GB / T 14825-2006 method for determining the suspension rate of pesticides, the pourability was tested according to the GB / T 31737-2015 method for determining the pourability of pesticides, and the spontaneous dispersibility in water was tested according to the CIPAC MT160 method.

[0073] Table 2 Performance of aqueous suspension concentrates prepared by compounding fluazinam and cyazofamid

[0074]

[0075]

[0076] As shown in Table 2, the quality of Comparative Examples 1, 2, 3, and 4 after hot storage was poor. Among them, samples 1 and 2 could not tolerate the high and low temperature range of -15°C to 65°C. After being stored at -15°C for 3 days and then transferred to room temperature, the samples solidified and had problems of discoloration and content reduction. Comparative Examples 1, 2, 3, and 4 were stored at 65°C for 3 days and then transferred to room temperature. The samples showed crystallization, poor fluidity, and solidification. The quality of Examples 2 and 3 deteriorated slightly after hot storage, with a small amount of water extraction and a slightly low suspension rate. The quality of Examples 1, 6, 7, 8, and 9 changed slightly after hot storage, and the suspension rate was slightly higher. However, the quality of Examples 4 and 5 was good before and after hot storage, and the dispersion stability was good in different water qualities. The preferred additive plays a key role in product quality.

[0077] The choice of additives is crucial for the stability of fluazifop and cyazofamid, particularly the use of wetting and dispersing agents such as naphthalenesulfonate formaldehyde condensate and pH control. The synergistic effect of these additives stabilizes the product's physical quality and prevents discoloration, ensuring no discoloration, decomposition, or crystallization during high-temperature storage.

[0078] Example 10

[0079] Based on the formula of Example 5 (Group A), the mass percentages of the wetting agent, dispersant and other additives were adjusted to obtain the following formula:

[0080] Table 3

[0081]

[0082]

[0083] Test Example 2 Performance Test

[0084] The properties of the aqueous suspension concentrate prepared in Example 10 were tested, and the results are shown in Table 4 below.

[0085] Table 4 Performance of aqueous suspension concentrates prepared by compounding fluazinam and cyazofamid

[0086]

[0087] Table 4 shows that changing the thickener ratio in Groups A, B, and C had no significant impact on other indicators, except for some changes in appearance and water separation. However, after adjusting the additive ratio in Groups D, E, and F, the suspension rate decreased to varying degrees within the acceptable range, while other indicators remained normal. Optimizing the additive ratio plays a key role in product quality.

[0088] Test Example 3: Field efficacy test on pepper blight:

[0089] This experiment was conducted at a vegetable base in Shouguang City. The control agents were 100 g / L cyazofamid suspension (commercially available) and 500 g / L fluazinam suspension (commercially available). Five treatments were set up: Treatment 1: water spray, blank control; Treatment 2: Example 3; Treatment 3: Example 5; Treatment 4: 100 g / L cyazofamid suspension; Treatment 5: 500 g / L fluazinam suspension. Each plot was 20 m 2 , the cells are randomly arranged.

[0090] Table 5: Application rate of each experimental group

[0091]

[0092] During the early stages of pepper blight, the pesticide was applied once using a Gongnong-16 knapsack sprayer. 750 kg of the formulation was diluted with water per hectare, and the amount of solution was converted to the plot volume for even spraying. The weather was good, with an average daily temperature of 20-30°C. There was no rain and no adverse weather conditions on the day of application.

[0093] Field efficacy survey, calculation, and statistical methods for pepper blight: Efficacy surveys were conducted three times before, 15 days after, and 30 days after application. Five random surveys were conducted at each plot, with five plants surveyed at each location. The number of diseased, dead, or visibly wilted plants was recorded. The results are shown in Table 6.

[0094] Grading method:

[0095] Level 0: healthy and asymptomatic;

[0096] Level 1: Only leaves and fruits above ground have lesions;

[0097] Level 3: There are brown rot spots on the aboveground stems and branches;

[0098] Level 5: Brown rot spots at the base of the stem;

[0099] Level 7: There are brown rot spots on the aboveground stems, branches and stem bases, and some branches are dead;

[0100] Level 9: The whole plant dies.

[0101] Calculation method of drug efficacy:

[0102]

[0103]

[0104] Note: In the formula, CK0 and CK1 are the disease indexes of the blank control area before and after application of pesticides; PT0 and PT1 are the disease indexes of the treated area before and after application of pesticides.

[0105] Table 6 Field efficacy test results of each treatment agent against pepper blight

[0106]

[0107] The results of the field efficacy test showed that the synergistic effect of fluazinam and cyazofamid was obvious after compounding. At a lower dosage, the control effect on pepper blight was significantly better than that of a single agent. In addition, Example 5 achieved a higher control effect by optimizing the adjuvant.

[0108] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A suspension concentrate containing fluazinam and cyazofamid, characterized in that: Measured by mass percentage, the suspending agent consists of the following components: Fluazinam 12%, cyazofamid 8%, naphthalenesulfonate formaldehyde condensate 1%, styrene acrylic acid copolymer sodium salt 2%, propylene oxide-ethylene oxide block polyether 1%, ordinary white carbon black 5%, ethylene glycol 20%, polyether defoamer 0.5%, paraformaldehyde 0.1% and the balance water; Or fluazinam 35%, cyazofamid 8%, octylphenol polyoxyethylene ether sodium phosphate 2%, lignin sulfonate sodium salt 2%, lauryl alcohol polyoxyethylene ether phosphate 3%, xanthan gum 0.15%, magnesium aluminum silicate 2%, glycerol 4%, silicone defoamer 0.2%, paraformaldehyde 0.5% and the balance water; Or fluazinam 48%, cyazofamid 8%, lignin sulfonate sodium salt 1%, formaldehyde cresol sulfonate sodium salt 2%, maleic rosin block polyether sulfonate ammonium salt 2%, xanthan gum 0.15%, magnesium aluminum silicate 2%, glycerol 4%, silicone defoamer 0.2%, paraformaldehyde 0.2% and the balance water; Or fluazinam 25%, cyazofamid 8%, styrene acrylic acid copolymer sodium salt 2%, naphthalene sulfonate formaldehyde condensate 2%, maleic rosin block polyether sulfonic acid ammonium salt 2%, xanthan gum 0.15%, magnesium aluminum silicate 0.5%, ethylene glycol 10%, silicone defoamer 0.2%, kasone 0.1% and the balance water; Or fluazinam 25.3%, cyazofamid 8.5%, styrene acrylic acid copolymer sodium salt 2%, naphthalenesulfonate formaldehyde condensate 2%, tristyrylphenol polyoxyethylene ether sulfate ammonium salt 2%, xanthan gum 0.15%, magnesium aluminum silicate 0.5%, ethylene glycol 5%, silicone defoamer 0.2%, kasone 0.1% and the balance water; Or fluazinam 25%, cyazofamid 13%, naphthalenesulfonate formaldehyde condensate 1%, styrene acrylic acid copolymer sodium salt 2%, octylphenol polyoxyethylene ether sulfate sodium salt 2%, xanthan gum 0.15%, ordinary white carbon black 3%, ethylene glycol 15%, silicone defoamer 0.2%, kason 0.3% and the balance water; Or fluazinam 25%, cyazofamid 17%, sodium laurylphenol polyoxyethylene ether sulfonate 4%, naphthalene sulfonate formaldehyde condensate 2%, propylene oxide-ethylene oxide block polyether 2%, magnesium aluminum silicate 1.5%, ethylene glycol 4%, polyether defoamer 3%, kasone 0.1% and the balance water; Or fluazinam 25%, cyazofamid 20%, styrene maleic anhydride copolymer sodium salt 4%, naphthalenesulfonate formaldehyde condensate 2%, dodecylsuccinic acid sulfonic acid sodium salt 1%, organic bentonite 1.5%, glycerol 5%, organosilicon defoamer 0.5%, paraformaldehyde 2% and the balance water; Or fluazinam 25%, cyazofamid 25%, styrene acrylic acid copolymer sodium salt 3%, tristyrylphenol polyoxyethylene ether sulfate ammonium salt 4%, lignin sulfonate sodium salt 4%, xanthan gum 0.2%, ethylene glycol 2%, silicone defoamer 1%, kasonon 1% and the balance water.

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