A kind of multi-layer pill for auxiliary replenishing qi and nourishing blood and its preparation process

Abstract

The invention discloses a multi-layer pill for supplementing qi and nourishing blood, which is composed of a pill core wrapped in an outer shell, wherein the outer shell includes a waterproof layer, a vitamin layer, an isolation layer, a mineral layer and a monosaccharide syrup protective layer from the inner layer to the outer layer, and the pill core is made of raw materials including base powder, a water retaining agent, a qi and blood composition and a flavoring agent; the waterproof layer is made of raw materials including gum syrup A and a compound stabilizer; the vitamin layer is made of raw materials including vitamins and gum syrup B; the isolation layer is made of monosaccharide syrup a; the mineral layer is made of raw materials including minerals and gum syrup C; the monosaccharide syrup protective layer is made of raw materials including monosaccharide syrup b and pigments. The invention places a reactive substance between different layers inside and outside, and an isolation layer is formed between layers by syrup, which plays a good role in isolating nutrients. The invention improves the stability of long-term storage of vitamins and solves the problem that the effective components and minerals in the extract under the same system will lead to a decrease in vitamin content.

Description

Technical Field

[0001] The invention relates to a multi-layer pill for auxiliary replenishing qi and nourishing blood and a preparation process thereof. Background Art

[0002] Anemia is the most common nutritional deficiency disease in the world and one of the most concerned public health issues at present. Nutritional anemia refers to a disease in which the formation of hemoglobin or red blood cells is insufficient due to the relative or absolute reduction of nutrients, metal elements and vitamins necessary for the body's blood production, thus leading to low hematopoietic function. Nutritional anemia is divided into two types in medicine: microcytic anemia and macrocytic anemia. The main type of microcytic anemia is iron-deficiency anemia (IDA), while macrocytic anemia is mainly megaloblastic anemia (MA). Globally, the most important factor leading to anemia is iron deficiency (IDA). Studies have shown that anemia caused by iron deficiency accounts for half of the total number of anemias. Early iron supplementation and enhanced utilization of iron are the key to preventing anemia. It is usually used in combination with vitamin C. Vitamin C can promote the absorption of iron, reduce trivalent iron to divalent iron, and prevent iron loss. Megaloblastic anemia is also an important type of anemia. Vitamin B 12 Folic acid deficiency and vitamin B 12 Absorption disorders are the main cause of the disease. Studies have shown that dietary deficiency of vitamin B 1 and B 2 , which will affect the absorption and utilization of iron.

[0003] "Suwen·Tiaojinglun" emphasizes that "what people have is blood and qi." Blood flows through the body through the veins, plays a role in nutrition and moisturizing, and provides nutrients for the physiological activities of the internal organs, meridians, body, and organs. It is the fundamental guarantee of human life activities. Replenishing qi and blood is equally important for women. Brown sugar, because it contains a lot of sugar and iron, can be used to replenish the body's qi and blood. Ginseng, wolfberry, and mulberry replenish qi and blood, sour jujube seeds, red dates, and longans nourish blood and calm the mind, and hawthorn promotes qi and blood circulation. Following the principle of balanced compatibility of monarch, minister, assistant, and envoy in traditional Chinese medicine, combined with nutritional enhancers, it can achieve the effect of combining Chinese and Western medicine and taking both symptoms and root causes into consideration.

[0004] However, most of the current preparations for anemia have a single function. For such preparations with rich nutrient types, stability and flavor are the basic requirements to ensure the supplement effect. It is well known that vitamins are affected by humidity, light, and oxygen, and minerals also accelerate the loss of vitamin activity. When minerals, complex extracts, and vitamins coexist in the preparation, the stability is poor. During the shelf life, the content of vitamins will be greatly reduced, and the vitamin intake is insufficient, which cannot achieve the desired effect of nutritional supplements. The applicant also found that iron ions have a significant effect on the flavor stability of the matrix containing cereals and milk powder, thus limiting the use of iron-rich supplements with cereals, milk powder, etc. as the matrix.

[0005] The solution to this problem in existing applications is usually to increase the amount of vitamins fed, or to embed materials such as iron, copper, zinc, and vitamins. Physical coating not only has low drug loading and high cost, but also affects dissolution and release to a certain extent, and the processing process is also easily damaged by factors such as temperature and pressure, and the application conditions are harsh. Another form is to use double-layer tablets, that is, to place the reacting substances in staggered layers, but the double layers in this preparation cannot be completely separated, the layers may cross, and it is not easy to achieve a multi-layer system for nutrients that need to be separated between the double layers. Patent No. CN107510701 A discloses a composition of iron supplements and vitamins for children. The patent only describes the stability of the added iron in the preparation, and does not describe the stability of the vitamins.

[0006] Therefore, it is necessary to maintain the flavor stability of the product, protect the stability of vitamins in vitamin compound preparations, and improve product quality. Summary of the invention

[0007] In order to solve the problems existing in the prior art (unstable flavor and efficacy), the present invention provides a multi-layer pill for auxiliary replenishing qi and nourishing blood and a preparation process thereof.

[0008] The technical solution adopted by the present invention is:

[0009] An auxiliary qi-invigorating and blood-nourishing multi-layer pill, the auxiliary qi-invigorating and blood-nourishing multi-layer pill is composed of a pill core wrapped in an outer shell, the outer shell comprising a waterproof layer, a vitamin layer, an isolation layer, a mineral layer and a simple syrup protective layer from the inner layer to the outer layer, the waterproof layer, the vitamin layer, the isolation layer, the mineral layer and the simple syrup protective layer are sequentially wrapped on the pill core from the inner layer to the outer layer;

[0010] The pill core is made of raw materials including base powder, water retaining agent, qi and blood composition and flavoring agent;

[0011] The waterproof layer is made of raw materials including gum syrup A and a compound stabilizer;

[0012] The vitamin layer is made from raw materials including vitamins and gum syrup B;

[0013] The isolation layer is made of monosaccharide syrup a;

[0014] The mineral layer is made from raw materials including minerals and gum syrup C;

[0015] The simple syrup protective layer is made from raw materials including simple syrup b and pigment.

[0016] Furthermore, the auxiliary qi-replenishing and blood-nourishing multi-layer pill preferably comprises 800-1500 parts by mass of a pill core, 80-300 parts by mass of a waterproof layer, 100-300 parts by mass of a vitamin layer, 30-100 parts by mass of an isolation layer, 200-700 parts by mass of a mineral layer, and 100-240 parts by mass of a monosaccharide syrup protective layer.

[0017] Preferably, the auxiliary qi-replenishing and blood-nourishing multi-layer pill comprises 800-1500 parts by weight of a pill core, 80-200 parts by weight of a waterproof layer, 100-250 parts by weight of a vitamin layer, 30-100 parts by weight of an isolation layer, 200-450 parts by weight of a mineral layer, and 100-200 parts by weight of a monosaccharide syrup protective layer.

[0018] Furthermore, the pill core is prepared from raw materials including the following components in parts by weight: 200-550 parts by weight of base powder, 200-590 parts by weight of water retaining agent, 115-590 parts by weight of qi and blood composition; and 0.01-10 parts by weight of flavoring agent.

[0019] Preferably, the pellet core is made of raw materials including the following components in parts by weight: 300-450 parts by weight of base powder, 300-450 parts by weight of water retaining agent, 190-380 parts by weight of qi and blood composition; and 0.01-10 parts by weight of flavoring agent.

[0020] Preferably, the base powder comprises 150-390 parts by mass of cereal powder, 50-130 parts by mass of sugar substances and 0.01-30 parts by mass of milk powder.

[0021] Furthermore, preferably, the cereal flour is one or more of glutinous rice flour, starch, and bean flour, and more preferably, the cereal flour includes 100 to 300 parts by mass of glutinous rice flour and 50 to 90 parts by mass of starch.

[0022] Preferably, the sugar substance is one or both of brown sugar and white granulated sugar.

[0023] More preferably, the base flour comprises 110-180 parts by mass of glutinous rice flour, 70-90 parts by mass of starch, 20-30 parts by mass of milk powder, and 100-120 parts by mass of brown sugar.

[0024] The water-retaining agent is preferably a mixture of water, glycerol, a sugar alcohol water-retaining agent and a water-retaining fiber, the water-retaining fiber is preferably one or two of microcrystalline cellulose and pea fiber, more preferably pea fiber or a mixture of pea fiber and microcrystalline cellulose. The sugar alcohol water-retaining agent is preferably one or more of sorbitol, maltitol, maltose syrup and fructose syrup.

[0025] Furthermore, it is preferred that the water retaining agent comprises 30 to 60 parts by mass of glycerin, 10 to 30 parts by mass of water, 60 to 200 parts by mass of sorbitol solution, and 100 to 300 parts by mass of pea fiber.

[0026] More preferably, the water retaining agent comprises 40-60 parts by mass of glycerin, 10-30 parts by mass of water, 100-160 parts by mass of sorbitol solution, and 150-200 parts by mass of pea fiber.

[0027] The sorbitol liquid is a commercially available food raw material, generally with a mass fraction of 50-75%, preferably 60-70%, and is a commonly used food additive raw material.

[0028] The qi and blood composition comprises one or more extracts having the effects of invigorating qi and nourishing blood, such as wolfberry extract, longan extract, mulberry extract, ginseng extract, spiny jujube seed extract, hawthorn concentrated juice, red date concentrated juice, and red date powder.

[0029] Preferably, the qi and blood composition includes the following components in weight: 1-50 parts by weight of wolfberry extract, 1-50 parts by weight of longan extract, 1-50 parts by weight of mulberry extract, 1-50 parts by weight of ginseng extract, 1-50 parts by weight of spinach seed extract, 50-120 parts by weight of hawthorn concentrated juice, 50-120 parts by weight of red date concentrated juice, and 10-100 parts by weight of red date powder.

[0030] More preferably, the qi and blood composition includes the following components in weight: 10-30 parts by weight of wolfberry extract, 10-30 parts by weight of longan extract, 5-20 parts by weight of mulberry extract, 5-20 parts by weight of ginseng extract, 1-10 parts by weight of spinach seed extract, 50-80 parts by weight of hawthorn concentrated juice, 80-120 parts by weight of red date concentrated juice, and 30-70 parts by weight of red date powder.

[0031] The flavoring agent includes one or more of essence, sour flavoring agent, and sweet flavoring agent. The essence includes one or more of red date essence and hawthorn essence. The sour flavoring agent includes one or more of citric acid and malic acid. The sweet flavoring agent includes one or more of mogroside and steviol glycoside.

[0032] The waterproof layer of the shell is made of raw materials including gum syrup A and a compound stabilizer;

[0033] The gum syrup A is a mixture of food gum, sugar alcohol substances and water, wherein the food gum is one or more of gum arabic, carrageenan, pectin and gelatin, and the sugar alcohol substances are one or more of maltitol, sorbitol, xylitol and erythritol;

[0034] Preferably, the gum syrup A comprises 0.5 to 5 parts by weight of food gum, 10 to 100 parts by weight of sugar alcohols, and 10 to 60 parts by weight of water.

[0035] More preferably, the gum syrup A comprises 1 to 5 parts by mass of food gum, 50 to 80 parts by mass of sugar alcohols, and 20 to 40 parts by mass of water.

[0036] The compound stabilizer is one or more of gum arabic, maltitol, and sucrose fatty acid ester.

[0037] Preferably, the compound stabilizer is a mixture of maltitol, gum arabic and sucrose fatty acid ester, and more preferably, the compound stabilizer comprises 100-300 parts by mass of maltitol, 10-70 parts by mass of gum arabic and 10-70 parts by mass of sucrose fatty acid ester.

[0038] More preferably, the composite stabilizer includes 150-200 parts by mass of maltitol, 40-60 parts by mass of gum arabic, and 30-50 parts by mass of sucrose fatty acid ester.

[0039] The usage ratio of the gum syrup A and the compound stabilizer is usually 18 to 28 parts by weight of the gum syrup A and 40 to 60 parts by weight of the compound stabilizer.

[0040] More preferably, the mass ratio of the gum syrup A to the compound stabilizer is 1:2 to 2.5.

[0041] The vitamin layer is made of raw materials including vitamins and gum syrup B, wherein the vitamin is vitamin B 1 , Vitamin B 2 , Vitamin B 12 , folic acid, vitamin C, vitamin B 6 , choline, and vitamin A.

[0042] Preferably, the vitamins include the following components in parts by weight: Vitamin B 1 0.01-1 parts by mass, vitamin B 2 0.01-1 parts by mass, vitamin B 12 0.001-1 parts by mass, 0.01-1 parts by mass of folic acid, and 0.01-100 parts by mass of vitamin C.

[0043] More preferably, the vitamins include the following components in parts by weight: Vitamin B 1 0.1-0.5 parts by weight, vitamin B 20.1-0.5 parts by weight, vitamin B 12 0.001-0.01 parts by mass, 0.1-0.5 parts by mass of folic acid, and 0.1-100 parts by mass of vitamin C.

[0044] The gum syrup B comprises 3 to 15 parts by weight of food gum, 100 to 250 parts by weight of sugar alcohol substances, and 50 to 150 parts by weight of water.

[0045] More preferably, the gum syrup B comprises 3 to 10 parts by mass of food gum, 100 to 150 parts by mass of sugar alcohols, and 50 to 90 parts by mass of water.

[0046] The usage ratio of vitamins and syrup B is usually 0.041-104 parts by mass of vitamins and 153-415 parts by mass of syrup B, preferably 0.4-2.5 parts by mass of vitamins and 153-250 parts by mass of syrup B.

[0047] The mineral layer is made from raw materials including minerals and gum syrup C;

[0048] The minerals are one or more trace element additives containing calcium, iron, zinc, selenium, copper and manganese that can be consumed by the human body, preferably one or two of ferric pyrophosphate and ferrous fumarate.

[0049] Preferably, the minerals include 8 to 20 parts by mass of ferric pyrophosphate and 5 to 20 parts by mass of ferrous fumarate.

[0050] The gum syrup C comprises 3 to 15 parts by weight of food gum, 150 to 300 parts by weight of sugar alcohol substances, and 80 to 150 parts by weight of water.

[0051] Preferably, the gum syrup C comprises 3 to 10 parts by weight of food gum, 150 to 200 parts by weight of sugar alcohols, and 90 to 120 parts by weight of water.

[0052] The usage ratio of mineral and gum syrup C is usually 13-40 parts by weight of mineral and 233-465 parts by weight of gum syrup C, preferably 13-40 parts by weight of mineral and 243-330 parts by weight of gum syrup C.

[0053] The monosaccharide syrup a of the isolation layer comprises a mixture of sugar alcohols and water, wherein the sugar alcohols are one or more of maltitol, sorbitol, xylitol and erythritol.

[0054] Furthermore, the monosaccharide syrup a comprises 10 to 40 parts by mass of sugar alcohols and 10 to 20 parts by mass of water.

[0055] The simple syrup protective layer is made from raw materials including simple syrup b and pigment.

[0056] The monosaccharide syrup b comprises 50 to 200 parts by mass of sugar alcohols and 20 to 100 parts by mass of water, and preferably comprises 80 to 120 parts by mass of sugar alcohols and 40 to 60 parts by mass of water.

[0057] The amount of the pigment used is 0.01 to 0.5 parts by weight.

[0058] In the present invention, gum syrups A, B, and C represent gum syrups used in different outer shell layers, with the same raw material components and different ratios of the raw material components, wherein A, B, and C play a distinguishing role, but A, B, and C have no chemical meaning.

[0059] In the present invention, monosaccharide a and b represent monosaccharide syrups used in different outer shell layers, the components of the raw materials are the same, and the proportions of the raw material components are different. A and b play a distinguishing role, but a and b have no chemical meaning.

[0060] The outermost layer of the shell of the auxiliary qi-invigorating and blood-nourishing multi-layer pill may also include a carnauba wax powder polishing layer.

[0061] The present invention also provides a method for preparing the auxiliary qi-invigorating and blood-nourishing multilayer pill, which comprises the following steps:

[0062] (1) mixing the base powder, the water retaining agent, the qi and blood composition and the flavoring agent according to the formula to obtain pellets; and passing the pellets through a pellet making machine to obtain pellet cores A;

[0063] (2) Put the prepared pill core A into a coating pan for coating according to the following process: waterproof layer coating → vitamin layer coating → isolation layer coating → mineral layer coating → monosaccharide syrup protective layer coating → polishing → pill drying, to obtain the auxiliary qi-invigorating and blood-nourishing multi-layer pills.

[0064] The step (1) is preferably carried out according to the following steps:

[0065] (1-1) Base powder mixing: Cereal powder, sugar substance and milk powder are mixed evenly according to the formula amount to prepare base powder;

[0066] (1-2) Mix water, glycerin, and sugar alcohol water-retaining agent according to the formula amount, boil, add the base powder of step (1), mix, then add water-retaining fiber, mix to obtain basic pellets;

[0067] (1-3) uniformly mixing the qi and blood composition, the seasoning and the basic pellets in the prescribed amount to prepare pellets;

[0068] (1-4) Pellet making: The pellets are passed through a pellet making machine to obtain pellet cores A;

[0069] Further, the pellet blocks are fed into a strip making machine to make pellet strips, and the pellet strips are cut by a strip straightening device and then rolled into balls. The moisture content is dried to 9-11%, and pellet cores A are obtained.

[0070] Furthermore, in the coating process, the waterproof layer is formed by placing the pill core A in a coating pan, spraying 18 to 28 parts by weight of gum syrup A to keep the surface of the pill core moist, then sprinkling 40 to 60 parts by weight of compound stabilizer powder, tumbling evenly and drying for 18 to 30 minutes, repeating several times until the weight increases by 8 to 13% to form a waterproof layer, and obtaining pill B;

[0071] In the coating process, the vitamin coating layer is to mix the formula amount of vitamins with gum syrup B to obtain compound vitamin gum syrup, add the compound vitamin gum syrup to pill B, roll evenly, dry, repeat in small amounts multiple times, until the formula amount of compound vitamin gum syrup is added, and obtain pill C;

[0072] In the coating process, the coating isolation layer is to add monosaccharide syrup a to pill C, tumble evenly, dry, and repeat several times until the weight increases by 3-5%, to obtain pill D;

[0073] In the coating process, the mineral coating layer is to mix the formulated amount of minerals with the gum syrup C to obtain a compound mineral gum syrup, add the compound mineral gum syrup to the pill D, roll evenly, dry, repeat in small amounts multiple times, until the formulated amount of compound mineral gum syrup is added, and obtain the pill E;

[0074] Among the raw materials, the particle size of ferrous fumarate is above 800 mesh, and the vitamin C is pulverized and passed through an 80-mesh sieve.

[0075] In the coating process, the monosaccharide syrup protective layer is prepared by adding a mixed raw material of monosaccharide syrup b and pigment to pill E, tumbling evenly, drying, and repeating the process several times until the weight increases by 8-11%, thereby obtaining pill F.

[0076] In the patina process, the polishing is to apply a layer of carnauba wax powder on the outside of the pills F to make the surface of the pills shiny;

[0077] The amount of carnauba wax powder used is usually 0.1 to 2 parts by mass.

[0078] In the patina process, the pill drying process is to place the polished pills at a temperature of 20 to 25° C. and a humidity of 30 to 40% for 10 to 15 hours.

[0079] In the present invention, the preparation of gum syrup or monosaccharide syrup can generally be heated to promote the dissolution of the solute, and the prepared gum syrup or monosaccharide syrup is generally kept warm at 60-70°C for use.

[0080] The present invention coats the core of the pellets, places the easily reactive substances between different inner and outer layers, forms an isolation layer of a certain thickness between the outer layers through the syrup, and plays a good isolation role between the nutrients.

[0081] The beneficial effects of the present invention are:

[0082] (1) Iron is added to the shell in the form of cladding, which is separated from the material in the core, ensuring the flavor stability of the grain powder and milk powder in the product. (2) Vitamins are placed in the shell in the form of cladding, separated from the material in the core, and substances that are easily reactive with each other are separated. The mineral layer and the vitamin layer in the shell are separated by an isolation layer, which improves the long-term storage stability of the vitamins, reduces the degradation rate of the vitamins, and solves the problem that the effective ingredients in the extracts and minerals in the same system will cause the vitamin content to decrease; (3) The outermost layer of the product is wrapped with syrup to block external oxygen and light, thereby improving the stability of the product; (4) A combination of multiple layers of cladding is provided to solve the problem of mutual reaction between different substances. DETAILED DESCRIPTION

[0083] The technical solution of the present invention is further described below with reference to specific embodiments, but the protection scope of the present invention is not limited thereto.

[0084] Example 1

[0085] 1. Pellet core preparation process

[0086] ① Base powder mixing: According to the formula, weigh 170 parts by mass of glutinous rice flour, 85 parts by mass of starch, 20 parts by mass of milk powder, and 105 parts by mass of brown sugar and mix them evenly.

[0087] ② Preparation of basic pellets: Weigh 120 parts by mass of sorbitol solution (mass fraction 60%) and 50 parts by mass of glycerol in the water retaining agent, add 20 parts by mass of water, boil, add the mixed base powder, mix evenly, add 170 parts by mass of pea fiber, mix evenly to obtain basic pellets.

[0088] ③ Preparation: Add the qi and blood composition and flavoring agent to the basic pills: add 90 parts by mass of red date concentrated juice, 60 parts by mass of hawthorn concentrated juice, 19.6 parts by mass of wolfberry extract, 25 parts by mass of longan extract, 10 parts by mass of mulberry extract, 10 parts by mass of ginseng extract, 5 parts by mass of spiny jujube kernel extract, 50 parts by mass of red date powder, 2 parts by mass of red date liquid flavor, and 2.5 parts by mass of mogroside, and mix well to obtain pills.

[0089] ④ Pill making: The pellets are put into a pellet making machine to obtain core A. Specifically, the pellets are made into strips by a strip making machine, and the strips are cut by a grooved roller through a strip straightener, rolled into balls, and dried at 60°C until the moisture content is about 10%. Core A is obtained.

[0090] 2. Patina preparation method

[0091] Waterproof layer → Vitamin layer → Isolation layer → Mineral layer → Monosaccharide syrup protective layer → Polishing → Drying the pellets. Patching parameters: Hot air temperature: 40-50℃ (gum syrup layer), 30-35℃ (monosaccharide syrup layer). Exhaust temperature 20℃, speed 7-9 rpm.

[0092] Specific steps:

[0093] Step 1: Waterproof layer:

[0094] Prepare gum syrup: weigh 70 parts by mass of maltitol powder and 2.4 parts by mass of gum arabic and mix them evenly, add them into 38 parts by mass of water to dissolve, heat and boil until the gum arabic is completely dissolved, and keep warm at 60-70°C.

[0095] Prepare the compound stabilizer: take 177 parts by mass of maltitol, 55.2 parts by mass of gum arabic, and 44 parts by mass of sucrose fatty acid ester and mix them evenly.

[0096] Place pill core A in the coating pot, preheat to 32°C, turn off the hot air, spray 20 parts by weight of prepared gum syrup each time, roll for 3 minutes, sprinkle in 50 parts by weight of compound stabilizer, roll for 4 minutes, then turn on the exhaust for 3 minutes, then turn on the hot air (40-50°C) and exhaust (20°C) at the same time for drying, dry for about 25 minutes, repeat the above steps until the weight of the pills increases by 11%, and obtain pill B.

[0097] Step 2: Vitamin layer: Weigh 125 parts by weight of maltitol powder and 4.5 parts by weight of gum arabic and mix them evenly, add them to 70 parts by weight of water to dissolve, heat and boil until the gum arabic is completely dissolved to obtain a glue solution, and keep it warm at 60-70°C. Take 60 parts by weight of the glue solution and add 0.2 parts by weight of vitamin B 1 , 0.2 parts by mass of vitamin B 2 , 0.0015 parts by mass of vitamin B 12 , 0.1 parts by mass of folic acid, and 0.3 parts by mass of vitamin C, mix evenly and pass through a 60-mesh sieve, add the remaining 139.5 parts by mass of glue to obtain a composite vitamin gum syrup.

[0098] Turn off the hot air, and after the temperature of pill B drops below 32°C, turn off the exhaust, add 15 parts by weight of compound vitamin gum syrup each time, tumble for 7 minutes, turn on the exhaust for 3 minutes, then turn on the hot air and exhaust for drying, the drying time is 10 minutes, and repeat the above operation until all the additions are completed to obtain pill C.

[0099] Step 3: Coating the isolation layer: Prepare syrup: weigh 26 parts by mass of maltitol powder, add it into 14 parts by mass of water to dissolve, heat and boil until the maltitol powder is completely dissolved, and keep warm at 60-70°C.

[0100] Turn off the hot air, and after the temperature of pill C drops below 32°C, turn off the exhaust, add 10 parts by weight of syrup each time, tumble for 7 minutes, turn on the exhaust for 2 minutes, then turn on the hot air and exhaust for drying, dry for 4 minutes, and repeat adding monosyrup until the weight increases by 3.5% to obtain pill D.

[0101] Step 4: Mineral coating: Weigh 173 parts by mass of maltitol powder, 6.6 parts by mass of gum arabic, 10 parts by mass of ferrous fumarate, and 12 parts by mass of ferric pyrophosphate and mix them evenly, add them into 105 parts by mass of water to dissolve, heat and boil until the gum arabic is completely dissolved to obtain a composite mineral gum syrup, and keep it warm at 60-70°C.

[0102] Turn off the hot air, and after the temperature of pill D drops below 32°C, turn off the exhaust, add 20 parts by weight of compound mineral gum syrup each time, tumble for 7 minutes, turn on the exhaust for 3 minutes, then turn on the hot air and exhaust for drying, the drying time is 10 minutes, and repeat the above operation until all the addition is completed to obtain pill E.

[0103] Step 5: Coat with a monosaccharide syrup protective layer: weigh 97 parts by mass of maltitol and 0.05 parts by mass of red iron oxide and mix them evenly, add them into 52.5 parts by mass of water to dissolve, heat and boil until completely dissolved, and keep warm at 60-70°C.

[0104] Turn off the hot air, and after the temperature of pill E drops below 32°C, turn off the exhaust, add 10 parts by weight of syrup each time, tumble for 7 minutes, turn on the exhaust for 2 minutes, then turn on the hot air and exhaust for drying, dry for 4 minutes, and repeat adding monosyrup until the weight increases by 10% to obtain pill F.

[0105] Step 6: Polishing: After adding the last layer of simple syrup, when the pills are 80% to 90% dry, cool down to room temperature, add 0.4 parts by weight of carnauba wax powder, roll and rub them together to produce a shiny finish, then sprinkle 0.2 parts by weight of wax powder until the surface is extremely shiny. Only exhaust is turned on during this process.

[0106] Step 7: Drying the pills: Move the polished pills to a drying room with a temperature of about 20-25°C and a humidity below 40% and leave them in the air for 12 hours.

[0107] Example 2

[0108] 1. Flavor stability test plan:

[0109] Comparative Example 1: According to the pellet core preparation process of step 1 of Example 1, a pellet core was prepared. Compared with the pellet core of Example 1, the difference was that in step ③, 10 parts by mass of ferric pyrophosphate, 12 parts by mass of ferrous fumarate and the qi and blood composition were mixed and added to the pellet core. The obtained pellet core and the pellet core of Example 1 were subjected to sensory evaluation. Acceleration conditions: temperature: 40°C, humidity 75%.

[0110] 30 selected sensory evaluators were selected to score the prepared pellets and the accelerated pellets respectively according to the data standards in Table 1 below, and the average scores were calculated. The results are shown in Table 2:

[0111]

Evaluation scale

[0112] Table 1 Flavor evaluation table

[0113] Points Intensity of musty and odorous smell 0 No musty or rancid smell 1 Very weak musty or rancid smell 2 Slight musty, rancid smell 3 Obvious musty and rancid smell 4 Very strong musty and rancid smell

[0114] Table 2 Evaluation results

[0115] Implementation Case 1 Comparative Example 1 Month 0 0 0 Acceleration Month 1 0 2.5 Accelerate the second month 1.1 3.2 Accelerate the 3rd month 1.8 3.8

[0116] Conclusion: As shown in Table 2, placing iron in the pellet core will accelerate the appearance of musty odors of cereals and rancid odors of milk powder.

[0117] 2. Nutrient stability test plan:

[0118] 2.1 Investigating the effects of Qi and blood composition on vitamins

[0119] Comparative Example 2: Referring to Example 1, the difference is that 0.2 parts by mass of vitamin B is added in the pellet core preparation step ③ 1 , 0.2 parts by mass of vitamin B 2 , 0.0015 parts by mass of vitamin B 12 , 0.1 parts by mass of folic acid, and 0.3 parts by mass of vitamin C, but no qi and blood composition is added.

[0120] Comparative Example 3: Referring to Example 1, the difference is that 0.2 parts by mass of vitamin B is added in the pellet core preparation step ③ 1 , 0.2 parts by mass of vitamin B 2 , 0.0015 parts by mass of vitamin B 12 , 0.1 parts by mass of folic acid, 0.3 parts by mass of vitamin C, and the qi and blood composition are mixed to prepare a pill core.

[0121] The pellet cores were subjected to an accelerated test and the vitamin content in the pellet cores was tested every month. The results are shown in Tables 3 and 4 below.

[0122] Table 3 Accelerated storage vitamin content

[0123]

[0124] Note: Accelerated storage conditions: bare pellets, temperature: 40°C, humidity 75%

[0125] Table 4 Vitamin content of accelerated storage

[0126]

[0127] Through the accelerated test, it can be concluded that after mixing the vitamins and the Qi and Blood composition, the degradation rate of the vitamins in Comparative Example 3 is significantly accelerated, while the degradation rate of the vitamins in Comparative Example 2 is relatively slow. After three months of acceleration, the vitamin content in Comparative Example 3 is basically maintained at 60-70% of the initial level, while that in Comparative Example 2 is basically maintained at more than 80%. It can be seen that the substances in the Qi and Blood composition have an impact on the stability of the vitamins and are not suitable for coexistence.

[0128] 2.2 Investigating the effects of minerals on vitamins

[0129] Comparative Example 4: The formula is the same as that of Example 1, except that there is no isolation layer in the middle.

[0130] Comparative Example 5: The formula is consistent with that of Example 1, the only difference being that the vitamins and minerals are mixed and placed in the same layer without isolation.

[0131] In comparative example 5, step 2: coating the vitamin and mineral layer: weigh 300 parts by mass of maltitol powder and 11 parts by mass of gum arabic and mix them evenly, add them to 174 parts by mass of water to dissolve, heat and boil until the gum arabic is completely dissolved to obtain a glue solution, and keep it warm at 60-70°C. Take 100 parts by mass of the glue solution, add 0.2 parts by mass of vitamin B 1 , 0.2 parts by mass of vitamin B 2 , 0.0015 parts by mass of vitamin B 12 , 0.1 parts by mass of folic acid, 0.3 parts by mass of vitamin C, 10 parts by mass of ferrous fumarate, and 12 parts by mass of ferric pyrophosphate are mixed evenly, and the remaining glue solution is added to obtain a composite glue syrup. Then directly proceed to step 5 in Example 1: coating a monosaccharide syrup protective layer and subsequent steps.

[0132] The multilayer pellets prepared in Example 1, Comparative Example 4 and Comparative Example 5 were subjected to accelerated storage, and the Fe and vitamin contents in the multilayer pellets were tested. The results are shown in Tables 5 and 6.

[0133] Table 5 Accelerated storage vitamin and iron content

[0134]

[0135] Note: Accelerated storage conditions: bare pellets, temperature: 40°C, humidity 75%

[0136] Table 6 Accelerated storage vitamin and iron content

[0137]

[0138] Through the accelerated test, it can be concluded that the degradation rate of vitamins in Example 1 and Comparative Example 4 is significantly reduced. After 3 months of acceleration, the vitamin content of Comparative Example 5 is basically less than half of the initial level, while Example 1 is basically maintained at more than 85%, and Comparative Example 4 is basically maintained at about 80%. It can be seen that the method of the present invention can effectively separate vitamins and iron through the layered packaging and isolation process, delay the degradation of vitamins, and improve the stability of the product.

Claims

1. An auxiliary qi - supplementing and blood - nourishing multi - layer pill, characterized in that the auxiliary qi - supplementing and blood - nourishing multi - layer pill is composed of a pill core wrapped by an outer shell. The outer shell from the inner layer to the outer layer is a waterproof layer, a vitamin layer, an isolation layer, a mineral layer, and a simple syrup protection layer. The waterproof layer, vitamin layer, isolation layer, mineral layer, and simple syrup protection layer are successively wrapped on the pill core from the inside to the outside; The pill core is prepared from the following components by mass: 200 - 550 parts by mass of base powder, 200 - 590 parts by mass of water - retaining agent, and 115 - 590 parts by mass of qi - blood composition; 0.01 - 10 parts by mass of flavoring agent; The base powder is a mixture of 150 - 390 parts by mass of cereal powder, 50 - 130 parts by mass of saccharide substance, and 0.01 - 30 parts by mass of milk powder; The cereal powder is one or more of glutinous rice flour, starch, and bean powder; the saccharide substance is one or two of brown sugar and white granulated sugar; the milk powder is one or two of whole milk powder and skim milk powder; The water - retaining agent is a mixture of 30 - 60 parts by mass of glycerol, 10 - 30 parts by mass of water, 60 - 200 parts by mass of sorbitol solution, and 100 - 300 parts by mass of pea fiber; The qi - blood composition is wolfberry extract, longan extract, mulberry extract, ginseng extract, wild jujube seed extract, concentrated hawthorn juice, concentrated red date juice, and red date powder; The waterproof layer is prepared from gum syrup A and compound stabilizer; the dosage ratio of gum syrup A to compound stabilizer is 18 - 28 parts by mass of gum syrup A and 40 - 60 parts by mass of compound stabilizer; The gum syrup A is a mixture of 0.5 - 5 parts by mass of food gum, 10 - 100 parts by mass of sugar alcohol substance, and 10 - 60 parts by mass of water; The food gum is one or more of arabic gum, carrageenan, pectin, and gelatin; the sugar alcohol substance is one or more of maltitol, sorbitol, xylitol, and erythritol; the compound stabilizer is one or more of arabic gum, maltitol, and sucrose fatty acid ester; The vitamin layer is prepared from vitamins and gum syrup B; the dosage ratio of vitamins to gum syrup B is 0.041 - 104 parts by mass of vitamins and 153 - 415 parts by mass of gum syrup B; The gum syrup B is a mixture of 3 - 15 parts by mass of food gum, 100 - 250 parts by mass of sugar alcohol substance, and 50 - 150 parts by mass of water; The isolation layer is prepared from simple syrup a; The simple syrup a is a mixture of 10 - 40 parts by mass of sugar alcohol substance and 10 - 20 parts by mass of water; The sugar alcohol substance is one or more of maltitol, sorbitol, xylitol, and erythritol; The mineral layer is prepared from minerals and gum syrup C; the dosage ratio of minerals to gum syrup C is 13 - 40 parts by mass of minerals and 233 - 465 parts by mass of gum syrup C; The gum syrup C is a mixture of 3 - 15 parts by mass of food gum, 150 - 300 parts by mass of sugar alcohol substance, and 80 - 150 parts by mass of water; The simple syrup protection layer is prepared from simple syrup b and pigment.

2. The auxiliary qi - supplementing and blood - nourishing multi - layer pill according to claim 1, characterized in that The auxiliary qi-invigorating and blood-nourishing multi-layer pill comprises: 800-1500 parts by weight of pill core, 80-300 parts by weight of waterproof layer, 100-300 parts by weight of vitamin layer, 30-100 parts by weight of isolation layer, 200-700 parts by weight of mineral layer and 100-240 parts by weight of simple syrup protective layer.

3. The multi-layered pill for supplementing qi and nourishing blood as claimed in claim 1, Features The flavoring agent includes one or more of flavors, sour flavoring agents, and sweet flavoring agents. The flavor includes one or two of red date flavor and hawthorn flavor. The sour flavoring agent includes one or two of citric acid and malic acid. The sweet flavoring agent includes one or two of mogroside and steviol glycoside.

4. The multi-layered pill for supplementing qi and nourishing blood as claimed in claim 1, Features The qi and blood composition is a mixture of the following raw materials: 1-50 parts by weight of wolfberry extract, 1-50 parts by weight of longan extract, 1-50 parts by weight of mulberry extract, 1-50 parts by weight of ginseng extract, 1-50 parts by weight of spinach seed extract, 50-120 parts by weight of hawthorn concentrated juice, 50-120 parts by weight of red date concentrated juice, and 10-100 parts by weight of red date powder.

5. The multi-layer pill for supplementing qi and nourishing blood as claimed in claim 1, Features The vitamin is vitamin B 1 , Vitamin B 2 , Vitamin B 12 , folic acid, vitamin C, vitamin B 6 , choline, and vitamin A.

6. The multi-layered pill for supplementing qi and nourishing blood as claimed in claim 1, Features The minerals are trace element additives that are edible by the human body and contain one or more of the elements calcium, iron, zinc, selenium, copper, and manganese; The monosaccharide syrup protective layer is made of monosaccharide syrup b and pigment; The monosaccharide syrup b is a mixture of 50-200 parts by weight of sugar alcohol and 20-100 parts by weight of water; The pigment is used in an amount of 0.01 to 0.5 parts by weight.

7. The multi-layered pill for supplementing qi and nourishing blood as claimed in claim 1, Features The outer layer of the simple syrup protective layer includes a carnauba wax powder polishing layer.

8. The method for preparing the auxiliary qi-invigorating and blood-nourishing multilayer pills as claimed in claim 7, Features The method comprises the following steps: (1) mixing the base powder, the water retaining agent, the qi and blood composition and the flavoring agent according to the formula to obtain pellets; and using the pellets in a pellet making machine to obtain pellet cores A; (2) Put the prepared pill core A into a coating pan and coat it according to the following process: waterproof layer coating → vitamin layer coating → isolation layer coating → mineral layer coating → monosaccharide syrup protective layer coating → polishing → pill drying, to obtain the auxiliary qi-invigorating and blood-nourishing multi-layer pills.

9. The method according to claim 8, Features In the coating process, the waterproof layer is formed by placing the pill core A in a coating pan, spraying 18 to 28 parts by weight of gum syrup A to keep the surface of the pill core moist, then sprinkling 40 to 60 parts by weight of compound stabilizer powder, rolling evenly and drying for 18 to 30 minutes, repeating several times until the weight increases by 8 to 13% to form a waterproof layer, and obtaining pill B; The vitamin coating layer is prepared by mixing a formula amount of vitamins with gum syrup B to obtain a compound vitamin gum syrup, adding the compound vitamin gum syrup to pill B, tumbling evenly, drying, and repeating the process in small amounts multiple times until the formula amount of compound vitamin gum syrup is added to obtain pill C; The isolation layer is prepared by adding monosaccharide syrup a to pill C, tumbling evenly, drying, and repeating several times until the weight increases by 3-5%, thereby obtaining pill D; The mineral coating layer is prepared by mixing a formulated amount of minerals with gum syrup C to obtain a compound mineral gum syrup, adding the compound mineral gum syrup to pills D, tumbling evenly, drying, and repeating the process in small amounts multiple times until the formulated amount of compound mineral gum syrup is added to obtain pills E; The monosaccharide syrup protective layer is prepared by adding a mixed raw material of monosaccharide syrup b and pigment to pill E, tumbling evenly, drying, and repeating for several times until the weight gain is 8-11%, thereby obtaining pill F; The polishing is to apply a layer of carnauba wax powder on the outside of the pills F to make the surface of the pills shiny; The pill drying step is to place the polished pills at a temperature of 20-25° C. and a humidity of 30-40% for 10-15 hours.

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