Multi-level antibacterial polymer colloid and device screen containing the colloid

Abstract

The present application relates to a multi-stage antibacterial polymer colloidal particle, which comprises a polymer scaffold and at least one antibacterial polymer loaded on the polymer scaffold, wherein the polymer scaffold and the at least one antibacterial polymer form a hollow colloidal particle. An antibacterial core can be accommodated within the hollow colloidal particle. The present application also relates to an antibacterial screen and a method for manufacturing an antibacterial screen, and the multi-stage antibacterial polymer colloidal particles can be incorporated into an optically transparent acrylic material to form an antibacterial coating. The antibacterial coating can be coated onto substrates such as glass, metal or plastic and cured by ultraviolet light to form a screen with antibacterial properties for electronic devices and the like.

Description

[0001] Cross - reference to related applications

[0002] This application claims the benefit of U.S. Provisional Patent Application No. 63 / 290,613, filed on December 16, 2021. Technical field

[0003] The disclosure of this patent application relates to antimicrobial treatment, and particularly to antimicrobial colloidal particles that can be used as additives for acrylate polymers, films, surface ornaments, coatings, etc. Background art

[0004] It is well known that bacterial colonization and subsequent biofilm formation on materials can deteriorate material properties such as optical transparency, texture, etc., and affect the normal function of the materials, while exposing users to the risk of infection. This risk is particularly relevant to high - touch surfaces, such as personal electronic devices, portable devices, lighting switches, door handles, kitchen countertops, stove tops, food utensil surfaces, and lavatory fixtures. Research on electronic devices has revealed the contamination of environmental pathogens and skin - dwelling bacteria, causing a high exposure risk. One study found that more than 80% of the bacteria carried by users would eventually contaminate their mobile device screens. This is particularly concerning due to the increasing prevalence of drug - resistant bacteria. Another study found that 69.9% of multi - drug - resistant bacteria were prevalent on the screens of common portable devices, and approximately 50% of the identified strains were resistant to ampicillin and trimethoprim - sulfamethoxazole. Hospital patients are particularly vulnerable to infection from contaminated mobile devices. The study also found that poor hand hygiene and contact with electronic devices are the reasons for the spread of infectious diseases between medical staff and those in contact with medical staff inside and outside the hospital. In addition, surface contaminants are considered an important transmission route for COVID - 19, especially for high - touch electronic surfaces.

[0005] Although ordinary cleaners and disinfectants can effectively remove dirt and microbial contaminants, they can corrode, damage the skin and device surfaces, and leave residual harmful chemicals and products on the skin and device surfaces. In addition, electronic devices usually need to be treated with detergents approved by the manufacturer, and special training is required to apply these detergents correctly to avoid surface damage, liquid penetration, and electrical short - circuit. Therefore, there is a need in the current market for multi - level antimicrobial polymer colloids and device screens containing such colloids that can solve the above problems. Summary of the invention

[0006] The multi-level antibacterial polymer colloid includes colloidal particles which, as non-limiting examples, can be used as antibacterial additives for acrylate polymers, films, surface ornaments, coatings, etc. The colloidal particles can be suspended in a suitable medium such as distilled deionized (DDI) water. Each multi-level antibacterial polymer colloidal particle includes a polymer scaffold and at least one antibacterial polymer loaded on the polymer scaffold. The polymer scaffold and the at least one antibacterial polymer form a hollow colloidal particle. As non-limiting examples, the polymer scaffold can be formed from polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), or a combination thereof. As non-limiting examples, the at least one antibacterial polymer can be at least one ionic polymer such as a polycationic polymer, a polyanionic polymer, or a mixed ionic polymer. As a further non-limiting example, the at least one antibacterial polymer can be polyethyleneimine (PEI), polyhexamethylene biguanide (PHMB), or a combination thereof.

[0007] Each multi-level antibacterial polymer colloidal particle can further include a core located within the hollow colloidal particle. The core can have antibacterial, antimicrobial, disinfectant, virucidal, fungicidal, and / or sporicidal properties. Non-limiting examples of such substances that can be included in the core include, but are not limited to, antibacterial metals, antibacterial metal ions, antibacterial metal oxides, antibacterial chemicals, antibacterial phytochemicals of plant origin, silver, silver compounds, silver salts, silver oxides, copper, copper compounds, copper salts, copper oxides, disinfectants, bactericidal short-chain polymers, bactericidal short-chain oligomers, ionic liquid compounds, alcohols, peracetic acid, essential oils, and combinations thereof.

[0008] An antibacterial screen for an electronic device can incorporate the above multi-level antibacterial polymer colloidal particles to impart antibacterial properties to the screen. The antibacterial screen includes a coating formed from an optically transparent acrylic material, and the coating incorporates multi-level antibacterial polymer colloidal particles. The coating can be applied onto a glass, metal, or plastic substrate.

[0009] The antibacterial screen can be manufactured by mixing the multi-level antibacterial polymer colloidal particles with an acrylate slurry to form a mixture. A radical catalyst is added to the mixture. As non-limiting examples, 2-hydroxy-2-methyl-propiophenone (2-HMP) can be used as the radical catalyst. As another non-limiting example, ammonium persulfate (APS) can be used as the radical catalyst. The mixture slurry is applied onto a glass, metal, or plastic substrate to form a uniform coating, and the mixture coating is cured on the substrate using ultraviolet curing. As non-limiting examples, the acrylate slurry can be 2-hydroxypropyl acrylate (2-HPA), N,N-dimethylacrylamide (DMAA), 1,6-hexanediol diacrylate (HDDA), or a combination thereof.

[0010] These and other features of the subject matter will become apparent after further reading the following specification. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] Figure 1A Shows an image of the multi - level antibacterial polymer colloidal particles at a magnification of 200X, where the multi - level antibacterial polymer colloidal particles are made of a polyvinyl alcohol (PVA) scaffold loaded with antibacterial polymers polyethyleneimine (PEI) and polyhexamethylene biguanide (PHMB).

[0012] Figure 1B Shows an image of the multi - level antibacterial polymer colloidal particles at a magnification of 200X, where the multi - level antibacterial polymer colloidal particles are made of a polyvinylpyrrolidone (PVP) scaffold loaded with antibacterial polymers polyethyleneimine (PEI) and polyhexamethylene biguanide (PHMB).

[0013] Figure 2A Shows the photolysis of 2 - hydroxy - 2 - methyl - acetophenone (2 - HMP) under ultraviolet (UV) excitation during the UV curing of an acrylate slurry coating mixed with multi - level antibacterial polymer colloids.

[0014] Figure 2B Shows the polymerization of 2 - hydroxypropyl acrylate (2 - HPA) by radical catalysis using a 2 - HMP radical catalyst during the UV curing of an acrylate slurry coating mixed with multi - level antibacterial polymer colloids.

[0015] Figure 2C Shows the polymerization of N,N - dimethylacrylamide (DMAA) by radical catalysis using a 2 - HMP radical catalyst during the UV curing of an acrylate slurry coating mixed with multi - level antibacterial polymer colloids.

[0016] Figure 3 Is a cross - sectional side view of an antibacterial screen made of a glass substrate, with a cured acrylate and multi - level antibacterial polymer (MAP) layer coated thereon.

[0017] Figure 4 Is a graph showing the measured thickness of the cured DMAA and MAP - 1 coatings and the measured thickness of the cured 2 - HPA and MAP - P coatings, where the thickness of each sample is averaged from eight measurement points.

[0018] Figure 5 Is a graph showing the measured roughness of the cured DMAA and MAP - 1 coatings and the measured roughness of the cured 2 - HPA and MAP - P coatings, where the roughness of each sample is averaged from eight measurement points.

[0019] Figure 6A Shows an optical microscope image of the cured DMAA and MAP - 1 coatings at a magnification of 100X.

[0020] Figure 6B Shows optical microscope images of the cured 2-HPA and MAP-P coatings at a magnification of 100X.

[0021] Figure 7A Shows optical microscope images of the cured 2-HPA and MAP-P coatings at a magnification of 500X.

[0022] Figure 7B Shows another optical microscope image of the cured 2-HPA and MAP-P coatings at a magnification of 500X.

[0023] Figure 8 Is a graph showing the optical transmittance results of the cured DMAA and MAP-1 coating samples and the cured 2-HPA and MAP-P coating samples.

[0024] Figure 9 Is a graph showing the swelling ratio and gel fraction test results of the screen samples prepared with 2-HPA and MAP-P.

[0025] Figure 10 Shows the log of the colony-forming units (CFU) of bacteria recovered from the surface of the cured acrylate-MAP screen sample after 60 seconds of contact. 10 Graph of reduction.

[0026] Figure 11 Shows the log of the colony-forming units (CFU) of bacteria and the plaque-forming units (PFU) of phages recovered from the surface of the cured acrylate-MAP screen sample after 10 minutes of contact. 10 Graph of reduction.

[0027] Throughout the drawings, like reference numerals always denote corresponding features. Detailed Description

[0028] The multi - level antibacterial polymer colloid includes colloid particles which, as non - limiting examples, can be used as antibacterial additives for acrylate polymers, membranes, surface ornaments, coatings, etc. The colloid particles can be suspended in a suitable medium, such as distilled deionized (DDI) water, etc. Each multi - level antibacterial polymer colloid particle includes a polymer scaffold and at least one antibacterial polymer loaded on the polymer scaffold. The polymer scaffold and the at least one antibacterial polymer form a hollow colloid particle. As non - limiting examples, the polymer scaffold can be formed from polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), or a combination thereof. As non - limiting examples, the at least one antibacterial polymer can be at least one ionic polymer, such as a polycationic polymer, a polyanionic polymer, or a mixed ionic polymer. As further non - limiting examples, the at least one antibacterial polymer can be polyethyleneimine (PEI), polyhexamethylene biguanide (PHMB), or a combination thereof.

[0029] Each multi - level antibacterial polymer colloid particle can further include a core located inside the hollow colloid particle. The core can have antibacterial, antimicrobial, disinfectant, virucidal, fungicidal, and / or sporicidal properties. Non - limiting examples of such substances that can be included in the core include, but are not limited to, antibacterial metals, antibacterial metal ions, antibacterial metal oxides, antibacterial chemicals, antibacterial phytochemicals of plant origin, silver, silver compounds, silver salts, silver oxides, copper, copper compounds, copper salts, copper oxides, disinfectants, bactericidal short - chain polymers, bactericidal short - chain oligomers, ionic liquid compounds, alcohols, peracetic acid, essential oils, and combinations thereof.

[0030] Table 1 below shows the compositions of four exemplary multi - level antibacterial polymer (MAP) colloids, referred to herein as "MAP - 1"; "MAP - 1 2*"; "MAP - P"; and "MAP - P 2*".

[0031] Table 1: Compositions of Exemplary MAP Colloids

[0032] Component MAP-1 MAP-1 2* MAP-P MAP-P 2* PVA 4.17 w / w% 4.17 w / w% - - PVP - - 4.17 w / w% 4.17 w / w% PHMB 0.33 w / w% 0.67 w / w% 0.33 w / w% 0.67 w / w% PEI 1.33 w / w% 2.67 w / w% 1.33 w / w% 2.67 w / w% DDI 94.17 w / w% 92.49 w / w% 94.17 w / w% 92.49 w / w%

[0033] Figure 1A and Figure 1B show images of MAP - 1 and MAP - P particles at a magnification of 200X, respectively. For Figure 1A and Figure 1B , the MAP - 1 and MAP - P colloids were prepared with hollow cores. 100 μL of each sample was placed on a 2.54×2.54 cm 2 glass slide and dried at room temperature for one hour. Figure 1A and Figure 1B The images shown in were taken using an Eclipse Ni2 microscope in bright field with a CCD camera.

[0034] Figure 1A Shows an image of the multi - level antibacterial polymer colloidal particles at a magnification of 200X, where the multi - level antibacterial polymer colloidal particles are made of a polyvinyl alcohol (PVA) scaffold loaded with antibacterial polymers polyethyleneimine (PEI) and polyhexamethylene biguanide (PHMB).

[0035] Figure 1B Shows an image of the multi - level antibacterial polymer colloidal particles at a magnification of 200X, where the multi - level antibacterial polymer colloidal particles are made of a polyvinylpyrrolidone (PVP) scaffold loaded with antibacterial polymers polyethyleneimine (PEI) and polyhexamethylene biguanide (PHMB).

[0036] The antibacterial screen for electronic devices can incorporate the above - mentioned multi - level antibacterial polymer colloidal particles to endow the screen with antibacterial properties. The antibacterial screen includes a coating formed of an optically transparent acrylic material, and the coating incorporates multi - level antibacterial polymer colloidal particles. The coating can be applied onto a glass, metal or plastic substrate.

[0037] Under rapid mixing, the multi - level antibacterial polymer colloidal particles are mixed with an acrylate slurry to form a viscous mixture, thereby preparing the antibacterial screen. A radical catalyst is added to the mixture. As a non - limiting example, 2 - hydroxy - 2 - methyl - phenylpropanone (2 - HMP) can be used as the radical catalyst. As another non - limiting example, ammonium persulfate (APS) can be used as the radical catalyst. The mixture slurry is applied onto a glass, metal or plastic substrate to form a uniform coating, and the mixture coating is cured on the substrate using ultraviolet curing. As non - limiting examples, the acrylate can be 2 - hydroxypropyl acrylate (2 - HPA), N,N - dimethylacrylamide (DMAA), 1,6 - hexanediol diacrylate (HDDA) or a combination thereof. Ultraviolet (UV) irradiation (e.g., at 352 nm) initiates the photolysis of 2 - HMP to generate benzoyl radicals and α - hydroxyalkyl radicals that catalyze the step - by - step polymerization of the acrylate.

[0038] Figure 2A Shows the photolysis of 2 - hydroxy - 2 - methyl - phenylpropanone (2 - HMP) under ultraviolet (UV) excitation. Figure 2B Shows the polymerization of 2 - hydroxypropyl acrylate (2 - HPA) using 2 - HMP as a radical catalyst by radical catalysis. Figure 2C Shows the polymerization of N,N - dimethylacrylamide (DMAA) using 2 - HMP as a radical catalyst by radical catalysis.

[0039] Table 2 below shows the composition of an exemplary antibacterial screen prepared as described above, where MAP - P colloid is used in combination with 2 - HPA, and MAP - 1 colloid is used in combination with DMAA.

[0040] Table 2: Composition of Exemplary Screens

[0041]

[0042] In the experiment, 0.5 mL of MAP-1 or MAP-P solution (using DDI water as the solvent) was added to 4.4 mL of DMAA or 2-HPA acrylate, and then vortexed for 1 minute to prepare the acrylate MAP mixture. The prepared acrylate MAP mixture was placed on a glass slide with an area of 2.54×2.54 cm 2 using a coating bar. The acrylate MAP coating was covered with a polyethylene terephthalate (PET) release film to prevent acrylate oxidation. Each acrylate MAP layer was coated with a bar having a height of 50 μm. UV curing was carried out in a chamber with a radiation intensity of 2.5 mW / cm 2 . The main UV wavelength was 352 nm, the irradiation time was 2 to 7 hours, the temperature was 19.2°C to 19.5°C, and the humidity was 33% RH to 37% RH.

[0043] After UV curing of the DMAA&MAP-1 and 2-HPA&MAP-P samples, the release film was removed, leaving a complete acrylate MAP coating. Figure 3 Sample screen 10 made on glass substrate 12 is shown, with a cured acrylate MAP layer 14 coated thereon. Experiments found that the sample formed by DMAA and MAP-1 could adhere to glass, and the sample formed by 2-HPA and MAP-P could adhere to PET plastic. Both samples were fully cured without surface defects or residues. Using a manufactured micrometer to measure the sample thickness, and a pressurized probe roughness meter to measure the sample surface roughness. Roughness measurements were carried out in accordance with ISO 1302 standard.

[0044] Figure 4 The measured thicknesses of the cured DMAA&MAP-1 and cured 2-HPA&MAP-P screen samples averaged over eight test points per sample are shown. Figure 5 The measured roughnesses of the cured DMAA&MAP-1 and 2-HPA&MAP-P screen samples averaged over eight test points per sample are shown. As Figure 5As shown, the measured roughness is less than the maximum allowable roughness of 1 μm for the LED display screen. The average thickness ± standard deviation (SD) of the DMAA&MAP-1 screen sample is 12.5 ± 1.4 μm. The average thickness ± SD of the 2-HPA&MAP-P screen sample is 11.9 ± 1.8 μm. The average roughness ± SD of the DMAA&MAP-1 screen sample is 0.4 ± 0.4 μm. The average roughness ± SD of the 2-HPA&MAP-P screen sample is 0.8 ± 0.3 μm.

[0045] As Figure 6A and Figure 6B shown, when the cured acrylate MAP sample was examined under an optical microscope, it was seen that the MAP colloid was embedded in the acrylate, indicating that the curing process did not damage the colloid structure. As Figure 7A and Figure 7B shown, at higher magnification, the MAP colloid of the 2-HPA&MAP-P sample was more obvious, and regular crystals could be seen in the cavities of the MAP colloid. These PEI / PHMB crystals can serve as an additional reserve of antibacterial agents for surface disinfection.

[0046] According to the "5.10 Opacity" section of the ISO / IEC 10373-1:2006(E) standard, the optical transmittance or transparency of the cured acrylate MAP sample was measured using a Varioscan spectrophotometer. As Figure 8 shown, the acrylate MAP sample had a light transmittance of more than 95% for wavelengths in the visible region (i.e., 400 nm to 800 nm), and was thus considered "optically transparent" according to industrial standards. For duplicate samples of each formulation, the measurement was effective in the range of 400 nm to 800 nm. In Figure 8 , the dashed line represents a transmittance of 95%.

[0047] The swelling ratio and gel fraction tests are convenient methods for measuring the amount of insoluble components and the degree of polymer crosslinking in a sample. The swelling ratio shows the increase caused by the absorption of water by oligomers and free polymers that are not crosslinked into the polymer network. The gel fraction measures the amount of insoluble components after soaking and drying, which generally represents the fraction of crosslinked or network polymers. According to the procedures published in ASTM D2765 and ISO 54759 standards, the cured acrylate MAP sample was allowed to absorb water by soaking in water at 37 °C for 36 hours. The swelling ratio was obtained by comparing the increased weight with the initial weight w0. The sample was further dried in an oven at 60 °C until a constant weight was obtained. The gel fraction is the ratio of the dry weight to the initial weight. The swelling ratio and gel fraction are calculated as follows:

[0048]

[0049]

[0050] where w0 is the initial weight, and w i is the weight of the sample after soaking in DDI water at 37 °C for 36 hours, while w D is the dry weight after drying at 60 °C for 2 hours.

[0051] For the swelling ratio and gel fraction tests, as described above, the 2-HPA and MAP-P screens were immersed in DDI water at 37 °C for 36 hours. Observation showed that the appearance of the cured acrylate MAP samples was the same before and after the swelling ratio and gel fraction tests. The swelling ratio of the 2-HPA and MAP-P screens was approximately 30%, and the gel fraction exceeded 99%, indicating that the samples were insoluble in water and fully crosslinked. This also confirmed that the incorporation of MAP did not affect the appearance and mechanical properties of the acrylate material. Figure 9 The results of the swelling ratio and gel fraction tests of the 2-HPA and MAP-P screen samples are shown, where the 30% dotted line of the swelling ratio represents a fully crosslinked polymer network, and the 90% dotted line of the gel fraction also confirms the formation of a stable and insoluble polymer network (experimental results are based on repeated sample tests).

[0052] Against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and Φ6 phage (virus surrogate), the antibacterial properties of the cured acrylate MAP screen samples were tested. Φ6 phage belongs to the only known family of enveloped phages - Cystoviridae. It is reported that its lipid envelope plays a role similar to that of human infectious viruses in virus survival tests. Under room temperature conditions, the microorganisms were tested on 2.54×2.54 cm 2 pieces of the cured acrylate MAP screen, and the contact time was 60 seconds or 10 minutes. The test conditions and operations complied with the requirements of European standard EN 13727, as well as ISO 22196, ASTM E3031, JIS L-1902, 2002, and GB-21551.2-2020.

[0053] Using 10 6 CFU of bacteria and 10 6 PFU of phage to specifically test 2.54×2.54 cm 2 pieces of the cured acrylate MAP screen. After contacting for 60 seconds or 10 minutes at room temperature (20 °C) and humidity (about 60% R.H.), the samples were vortexed in D / E neutralizing broth containing 3% 80, 3% saponin, and 0.3% lecithin at pH 7.0 to terminate the disinfection reaction. As Figure 10As shown, after 60 seconds of contact, the survival rates of Escherichia coli and Staphylococcus aureus decreased by more than 98%, indicating that the sample achieved rapid surface disinfection. Figure 11 It is shown that after 10 minutes of contact, the acrylate MAP screen sample can achieve a 99% reduction in bacteria, thus meeting the ISO 22196 requirements. The surviving Φ6 phages decreased by more than 90%. The blank acrylate sample used as a negative control had no bactericidal or virucidal activity. The tests were conducted using triplicate samples.

[0054] Tables 3 and 4 show the bactericidal and virucidal test results of the acrylate MAP sample after 60 seconds of contact and after 10 minutes of contact, respectively.

[0055] Table 3: Bactericidal Results after 60 Seconds of Contact

[0056]

[0057] Table 4: Bactericidal and Virucidal Results after 10 Minutes of Contact

[0058]

[0059] It should be understood that the multi-level antibacterial polymer colloid and the device screen containing the colloid are not limited to the above specific embodiments, but include any and all embodiments within the general scope of the following claims, which are permitted by the embodiments described herein, or otherwise shown in the drawings, or described above in terms sufficient to enable a person of ordinary skill in the art to make and use the claimed subject matter.

Claims

1. An antibacterial screen, comprising: A coating comprising an optically transparent acrylic material and multi - level antibacterial polymer colloidal particles incorporated into the optically transparent acrylic material, wherein the acrylic material is selected from the group consisting of 2 - hydroxypropyl acrylate (2 - HPA), N,N - dimethylacrylamide (DMAA), 1,6 - hexanediol diacrylate (HDDA), and combinations thereof, and each of the multi - level antibacterial polymer colloidal particles consists of: A polymer scaffold, the polymer scaffold being polyvinylpyrrolidone (PVP); and At least one antibacterial polymer loaded on the polymer scaffold, the at least one antibacterial polymer being selected from the group consisting of polyethyleneimine (PEI), polyhexamethylene biguanide (PHMB), and combinations thereof, Wherein the polymer scaffold and the at least one antibacterial polymer form hollow colloidal particles; and A substrate comprising a material selected from the group consisting of glass, metal, and plastic, Wherein the coating is applied onto the substrate.

2. The antibacterial screen according to claim 1, wherein each of the multi - level antibacterial polymer colloidal particles further comprises an antibacterial core located within the hollow colloidal particles.

3. The antibacterial screen according to claim 2, wherein the antibacterial core comprises an antibacterial agent selected from the group consisting of antibacterial metals, antibacterial metal ions, antibacterial metal oxides, antibacterial chemicals, antibacterial phytochemicals of plant origin, silver, silver compounds, silver salts, silver oxides, copper, copper compounds, copper salts, copper oxides, disinfectants, bactericidal short - chain polymers, bactericidal short - chain oligomers, ionic liquid compounds, alcohols, peracetic acid, essential oils, and combinations thereof.

4. A method of manufacturing an antibacterial screen, comprising the steps of: Mixing multi - level antibacterial polymer colloids and an acrylate slurry to form a mixture, wherein the acrylate slurry is selected from the group consisting of 2 - hydroxypropyl acrylate (2 - HPA), N,N - dimethylacrylamide (DMAA), 1,6 - hexanediol diacrylate (HDDA), and combinations thereof, the multi - level antibacterial polymer colloids consist of multi - level antibacterial polymer colloidal particles and a medium, and each of the multi - level antibacterial polymer colloidal particles consists of a polymer scaffold and at least one antibacterial polymer loaded on the polymer scaffold, wherein the polymer scaffold is polyvinylpyrrolidone (PVP), the at least one antibacterial polymer is selected from the group consisting of polyethyleneimine (PEI), polyhexamethylene biguanide (PHMB), and combinations thereof, and the polymer scaffold and the at least one antibacterial polymer form hollow colloidal particles; Adding a radical catalyst to the mixture; Coating the mixture slurry onto a substrate to form a uniform coating, wherein the substrate comprises a material selected from the group consisting of glass, metal, and plastic; And Curing the mixture coating using ultraviolet curing.

5. The method of manufacturing an antibacterial screen according to claim 4, wherein each of the multi - level antibacterial polymer colloidal particles further comprises an antibacterial core located within the hollow colloidal particles.

6. The method of manufacturing an antibacterial screen according to claim 5, wherein the antibacterial core contains an antibacterial agent selected from the group consisting of antibacterial metals, antibacterial metal ions, antibacterial metal oxides, antibacterial chemicals, antibacterial phytochemicals of plant origin, silver, silver compounds, silver salts, silver oxides, copper, copper compounds, copper salts, copper oxides, disinfectants, bactericidal short-chain polymers, bactericidal short-chain oligomers, ionic liquid compounds, alcohols, peracetic acid, essential oils, and combinations thereof.

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