Drug release capsules

Abstract

The present invention discloses a drug-releasing capsule, comprising: a shell, a first cavity arranged in the shell, a second cavity and a valve body assembly for controlling the conduction or closing of the first cavity and the second cavity; the drug-releasing capsule also comprises a drug chamber with a drug cavity, the drug chamber is arranged in the first cavity and the drug chamber can shrink and deform after being pressurized; an inlet is arranged on the drug chamber, an outlet is arranged on the shell, the drug-releasing capsule comprises a pipe connecting the inlet and the outlet, and a drug-releasing channel connecting the drug cavity with the outside is formed in the pipe; the pipe has a controllable part, and under the action of the air pressure in the second cavity, the controllable part is in a closed state of closing the drug-releasing channel; when the air pressure of the second cavity decreases and / or the air pressure in the drug chamber increases, the controllable part is in a conducting state of conducting the drug-releasing channel. The embodiment of the present invention can realize the control of the closing or conducting of the drug-releasing channel with a simpler structure without adding additional power control, and conveniently realizes the control of the release of drugs from the drug-releasing capsule.

Description

Technical Field

[0001] The invention relates to the technical field of medical devices, in particular to a drug-releasing capsule. Background Art

[0002] The controlled release of drugs can improve the therapeutic effect of drugs and reduce side effects, especially for the difficult-to-reach sections of the digestive tract. The use of capsule drug delivery has received more and more attention. It has the advantages of being non-destructive, painless, having a wide coverage range, and precise drug release.

[0003] In order to achieve drug release, a drug-releasing capsule is disclosed in the prior art, wherein a capsule is provided inside the capsule, and the capsule is used to store drugs. The capsule is placed in the inner cavity of the shell, and during the drug release process, the capsule is squeezed, and the drugs stored in the capsule flow outward through the drug release channel to achieve drug administration. In the existing solution, in order to achieve drug extrusion, a set of hot melt control devices is required to control the gas to enter the cavity where the capsule is located to squeeze the capsule. At the same time, in order to avoid drug leakage during operation, another set of hot melt control devices is required to control the conduction or closing of the drug release channel. The above two sets of hot melt control devices require two sets of electronic equipment, which not only causes inconvenience in drug release control, but also increases the cost due to the complex structure. Summary of the invention

[0004] The object of the present invention is to provide a drug-releasing capsule that can achieve control of the closing or opening of a drug-releasing channel with a simpler structure without adding additional power control, thereby facilitating control of drug release from the drug-releasing capsule.

[0005] The drug-releasing capsule provided by the present invention comprises: a shell, a first cavity and a second cavity arranged in the shell, and a valve body assembly for controlling the connection or closing of the first cavity and the second cavity;

[0006] The drug-releasing capsule further comprises a drug chamber having a drug cavity, wherein the drug chamber is arranged in the first cavity and can shrink and deform after being pressurized; an inlet is arranged on the drug chamber, and an outlet is arranged on the shell, and the drug-releasing capsule comprises a pipe connecting the inlet and the outlet, and a drug-releasing channel connecting the drug cavity and the outside is formed in the pipe;

[0007] The pipeline has a controllable portion, and under the action of the air pressure in the second cavity, the controllable portion is in a closed state to close the drug release channel;

[0008] When the air pressure in the second chamber decreases and / or the air pressure in the medicine chamber increases, the controllable portion is in a conducting state for conducting the medicine release channel.

[0009] Furthermore, when the valve body assembly is opened, the gas in the second cavity flows toward the first cavity, the air pressure in the second cavity decreases, and the air pressure in the first cavity increases and squeezes the medicine chamber to increase the air pressure in the medicine chamber.

[0010] Furthermore, the controllable portion is an elastically deformable part, and under the action of the air pressure in the second cavity, the controllable portion expands and deforms toward the drug release channel to close the drug release channel.

[0011] Furthermore, a through hole connecting the drug release channel and the second cavity is provided on the pipeline, the controllable part covers and closes the through hole, and part of the controllable part is located in the second cavity.

[0012] Furthermore, the controllable part includes an elastic deformation film fixed on the pipe, and the edge of the elastic deformation film is connected and fixed to the edge of the through hole;

[0013] The elastically deformable film has a first side surface exposed toward the drug-releasing passage, and a second side surface of the elastically deformable film facing away from the drug-releasing passage is exposed toward the second cavity.

[0014] Furthermore, the controllable part includes an elastic tube sleeved outside the pipeline, the elastic tube is connected and fixed to the pipeline, and the elastic tube covers the through hole;

[0015] Under the action of the air pressure in the second cavity, the portion of the elastic tube opposite to the through hole expands and deforms toward the drug release channel to close the drug release channel.

[0016] Furthermore, the through holes are provided in plurality and arranged along the extension direction of the pipeline.

[0017] Furthermore, the controllable part is a hose or an elastic tube, which has a tube body and a tube hole passing through the tube body, the tube hole is a part of the drug release channel, and part of the tube body is arranged in the second cavity; under the action of the air pressure in the second cavity, the tube body contracts and deforms to close the tube hole.

[0018] Further, the pipeline includes a first pipeline connected to the inlet, and the controllable part connects the first pipeline and the outlet;

[0019] Or the pipeline includes a second pipeline connected to the outlet, and the controllable part connects the inlet and the second pipeline;

[0020] Or the pipeline includes a first pipeline communicating with the inlet and a second pipeline communicating with the outlet, and the controllable part communicates with the first pipeline and the second pipeline;

[0021] Or the entire pipeline is a controllable portion, and the controllable portion connects the inlet and the outlet.

[0022] Furthermore, the controllable part is a soft capsule disposed in the drug release channel, and the soft capsule is communicated with the second cavity;

[0023] Under the action of the air pressure in the second chamber, the soft capsule is supported in the drug release channel to close the drug release channel; under the action of the air pressure in the drug chamber, the soft capsule is folded in the drug release channel to open the drug release channel.

[0024] Furthermore, the drug-releasing capsule further comprises a connecting channel connecting the drug-releasing channel and the second cavity.

[0025] The connecting channel comprises a channel outlet located on the inner wall of the drug release channel and a channel inlet extending in the second cavity;

[0026] The controllable portion is arranged at the edge of the channel outlet and closes the channel outlet, and the drug-releasing capsule also has a pressure-bearing deformation portion arranged at the edge of the channel inlet and closes the channel inlet;

[0027] After being acted upon by the air pressure in the second cavity, the pressure-bearing deformation portion contracts and deforms or expands and deforms toward the connecting channel, and the pressure-bearing deformation portion drives the controllable portion to expand and deform toward the drug release channel to close the drug release channel.

[0028] Furthermore, the controllable part is an elastically deformable part, and under the action of the air pressure in the second cavity, the controllable part expands and deforms in the drug release channel to close the drug release channel;

[0029] After the air pressure in the second chamber decreases, the controllable portion is reset and rebounds to open the drug release channel.

[0030] Furthermore, the drug-releasing capsule also has a pressurization channel connected to the second cavity for filling the second cavity with pressurized gas, and the pressurization channel includes a pressurization inlet arranged on the shell.

[0031] Furthermore, a partition plate is provided in the shell, the partition plate separates the first cavity and the second cavity, a cavity channel connecting the first cavity and the second cavity is provided on the partition plate, and the valve body assembly controls the opening or closing of the cavity channel.

[0032] Furthermore, the valve body assembly includes a hot melt, which is in a solidified state in an initial state and closes the cavity channel; when the hot melt is heated, the hot melt melts and opens the cavity channel;

[0033] The valve body assembly also has a heating element arranged outside the hot melt body, and the drug-releasing capsule also has a battery unit for providing electrical energy to the heating element, and the battery unit is arranged in the second cavity.

[0034] The beneficial effect of the present invention is that the state of the controllable part is adjusted by directly or indirectly adjusting the air pressure change in the chamber where the controllable part is located on the pipeline, thereby controlling the opening or closing of the drug release channel in the pipeline. It is achieved that the closing or opening of the drug release channel can be controlled with a simpler structure without adding additional power control, which facilitates the control of drug release from the drug release capsule. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 It is a schematic structural diagram of the first drug-releasing capsule disclosed in an embodiment of the present invention before drug release;

[0036] Figure 2 It is a schematic diagram of the structure of the first drug-releasing capsule disclosed in an embodiment of the present invention after the drug is released;

[0037] Figure 3 It is a schematic structural diagram of the controllable part of the first drug-releasing capsule disclosed in an embodiment of the present invention before drug release;

[0038] Figure 4 It is a schematic structural diagram of the controllable part of the first drug-releasing capsule disclosed in an embodiment of the present invention after drug release;

[0039] Figure 5 yes Figure 4 Bottom view of

[0040] Figure 6 is a schematic structural diagram of a second drug-releasing capsule disclosed in an embodiment of the present invention;

[0041] Description of reference numerals: 1-housing, 101-first cavity, 102-second cavity, 11-pressurization inlet, 12-partition plate, 120-cavity channel, 13-medication soft rubber plug, 14-outlet,

[0042] 2-valve body assembly, 21-heating element,

[0043] 3-medicine chamber, 30-medicine cavity, 31-inlet,

[0044] 4-pipe, 40-drug release channel, 41-controllable part, 411-tube body, 412-tube hole, 42-through hole,

[0045] 5-control module, 51-battery unit, 52-electronic control unit,

[0046] 6-imaging module, 61-circuit board, 62-camera, 63-fill light. DETAILED DESCRIPTION

[0047] The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, but should not be construed as limiting the present invention.

[0048] The embodiment of the present invention discloses a drug-releasing capsule, wherein a drug chamber with a drug cavity is provided in the drug-releasing capsule, wherein the drug chamber is used to store a substance to be released, wherein the substance to be released may be a drug, for example, and the drug chamber is a drug chamber. The drug is stored in the drug chamber as a substance to be released and enters the human body, such as the digestive tract section of the human body, along with the drug-releasing capsule, and is released after reaching the drug-releasing area, i.e., the lesion area, thereby achieving accurate drug delivery, aligning the drug-releasing outlet with the lesion, and allowing the drug to be sprayed on the lesion, which can further improve the efficacy of the drug.

[0049] Specifically, Figure 1-5 As shown, the drug-releasing capsule disclosed in the present invention comprises: a shell 1, a first cavity 101 and a second cavity 102 arranged in the shell 1, and a valve body assembly 2 for controlling the connection or closing of the first cavity 101 and the second cavity 102;

[0050] The drug-releasing capsule further comprises a drug chamber 3 having a drug cavity 30, the drug chamber 3 being arranged in the first cavity 101 and being capable of shrinking and deforming after being pressurized; an inlet 31 is arranged on the drug chamber 3, an outlet 14 is arranged on the shell 1, the drug-releasing capsule comprises a pipe 4 connecting the inlet 31 and the outlet 14, and a drug-releasing channel 40 connecting the drug cavity 30 and the outside is formed in the pipe 4;

[0051] The pipeline 4 has a controllable portion 41. Under the action of the air pressure in the second chamber 102, the controllable portion 41 is in a closed state to close the drug release channel 40.

[0052] When the air pressure in the second chamber 102 decreases and / or the air pressure in the medicine chamber 3 increases, the controllable portion 41 is in a conducting state for conducting the medicine release channel 40 .

[0053] In the present invention, the state of the controllable part 41 can be adjusted by directly or indirectly adjusting the air pressure change in the chamber where the controllable part 41 is located on the pipeline 4, thereby controlling the opening or closing of the drug release channel 40 in the pipeline 4. It is achieved that the closing or opening of the drug release channel 40 can be controlled with a simpler structure without adding additional power control, which facilitates the control of the release of drugs from the drug release capsule.

[0054] During use, the second chamber 102 may be filled with pressurized gas in advance. In the initial state, the valve body assembly 2 is in a closed state. At this time, the first chamber 101 and the second chamber 102 are not connected. The pressurized gas in the second chamber 102 acts on the controllable part 41. Under the action of the air pressure in the second chamber 102, the controllable part 41 may, for example, expand and deform to close the drug release channel 40. Since the drug release channel 40 is closed under the action of the controllable part 41, the drug stored in the drug chamber 30 in the initial state can be stably stored.

[0055] In the drug release state, the valve body assembly 2 is in a conducting state, at which time the first chamber 101 and the second chamber 102 are conducting, and the pressurized gas pre-filled in the second chamber 102 enters the first chamber 101 and squeezes the drug chamber 3 in the first chamber 101. The drug chamber 3 shrinks and deforms after being squeezed, and the air pressure in the drug chamber 3 increases accordingly. At the same time, due to the release of the air pressure in the second chamber 102, the air pressure acting on the controllable part 41 is weakened, and the controllable part 41 can be deformed or folded under the action of the pressure difference between the inside and outside of the controllable part 41 to achieve the conduction of the drug release channel 40. The drug in the drug chamber 30 can be released outward along the drug release channel 40 after being squeezed, thereby achieving drug release.

[0056] The air pressure in the second cavity 102 acts on the controllable part 41, tending to change the controllable part 41 toward the closed state of the closed drug release channel 40, and the drug chamber 3 is connected to the drug release channel 40. The air pressure in the drug chamber 3 acts on the controllable part 41 through part of the drug release channel 40, tending to change the controllable part 41 toward the conductive state of the conductive drug release channel 40.

[0057] In this embodiment, in order to better control the controllable part 41 so that the controllable part 41 can be more conveniently switched between the closed state and the conducting state, the reduced air pressure in the second chamber 102 is used to control the increase of the air pressure in the medicine chamber 3 .

[0058] Specifically, when the valve body assembly 2 is opened, the gas in the second chamber 102 flows toward the first chamber 101, the air pressure in the second chamber 102 decreases, and the air pressure in the first chamber 101 increases and squeezes the medicine chamber 3 to increase the air pressure in the medicine chamber 3. The air pressure released in the second chamber 102 acts on the medicine chamber 3 and squeezes the medicine chamber 3, thereby indirectly increasing the air pressure in the medicine chamber 3.

[0059] In the present embodiment, the controllable part 41 is actually switched between different states through the linkage change of the second cavity 102 and the air pressure in the medicine chamber 3 with a clever structural design. The change of the state of the controllable part 41 controls the opening or closing of the drug release channel 40, thereby better realizing the control of drug release. The control system for adjusting the air pressure change in the chamber where the controllable part 41 is located is actually shared with the control system for controlling the increase of the air pressure in the medicine chamber 3 to squeeze the medicine chamber 3 to release the drug.

[0060] It is understandable that in other embodiments, the change in the state of the controllable part 41 can be achieved simply by increasing the air pressure in the medicine chamber 3; of course, the change in the state of the controllable part 41 can also be achieved simply by reducing the air pressure in the second chamber 102.

[0061] It should be noted that the medicine bin 3 in the present invention is an elastically deformable capsule, which can shrink and deform after being subjected to external pressure, thereby releasing the medicine stored in the medicine cavity 30. Of course, in other embodiments, the medicine bin 3 can also be configured as a shrinkable and deformable compression tube extending in a specific direction or an elastic deformable member with an accommodating space. As a preferred solution, the medicine bin 3 can be made of rubber, silicone or latex.

[0062] In the above embodiment, the medicine chamber 3 compresses the medicine cavity 30 by generating deformation. It should be noted that there are many ways to compress a space to release the substance to be released in the space in the prior art. Here, only a specific way is given as an example, but it is not limited to this. For those skilled in the art, when releasing the medicine in the medicine cavity 30, they can think of combining some existing ways.

[0063] In order to better enable the controllable part 41 to control the closing or opening of the drug release channel 40 in the present invention, the controllable part 41 is an elastic deformable part. Under the action of the air pressure in the second cavity 102, the controllable part 41 expands and deforms toward the drug release channel 40 to close the drug release channel 40.

[0064] It can be understood that in order to facilitate the effect of the air pressure in the second chamber 102 on the controllable part 41, in one embodiment, at least part of the controllable part 41 is located in the second chamber 102, and the controllable part 41 has a part exposed toward the second chamber 102, so that the pressurized gas pre-stored in the second chamber 102 can act on the controllable part 41.

[0065] In order to conveniently realize that the controllable part 41 is located in the second cavity 102, a through hole 42 connecting the drug release channel 40 and the second cavity 102 is provided on the pipe 4, and the controllable part 41 covers and closes the through hole 42. Under the action of the air pressure in the second cavity 102, the controllable part 41 expands and deforms toward the drug release channel 40 to close the drug release channel 40.

[0066] Since the controllable part 41 closes the through hole 42 and is exposed to the second cavity 102, after the controllable part 41 is acted upon by the air pressure in the second cavity 102, the controllable part 41 expands toward the drug release channel 40 accordingly, and the drug release channel 40 can be blocked during the expansion of the controllable part 41 toward the drug release channel 40. It should be noted that since the controllable part 41 is an elastically deformable part, the air pressure in the second cavity 102 needs to overcome the combined effect of the rebound force of the controllable part 41 and the air pressure in the drug chamber 3.

[0067] In this embodiment, the change of the state of the controllable part 41 is actually determined by the pressure difference of the two chambers on both sides of the controllable part 41. Specifically, the controllable part 41 is located in both the drug release channel 40 and the second chamber 102, and the drug release channel 40 is connected to the drug chamber 3. Therefore, the change of the state of the controllable part 41 is adjusted by the change of the pressure difference between the air pressure P1 in the drug chamber 3 and the air pressure P0 in the second chamber 102. When P0-P1 is large enough, the controllable part 41 is deformed in the direction of the drug release channel 40 to close the drug release channel 40. When P0-P1 is small enough, the controllable part 41 is deformed or reset in the direction of the second chamber 102 accordingly, thereby realizing the conduction of the drug release channel 40.

[0068] It is understandable that when the controllable portion 41 is an elastic deformable member, the pressure difference P0-P1 needs to overcome the restoring resilience force accumulated in the controllable portion 41 during the deformation process in order to deform the controllable portion 41 toward the drug release channel 40.

[0069] In the present invention, in order to enable the controllable part 41 to open the drug release channel 40 more efficiently after the force exerted by the air pressure in the second chamber 102 on the controllable part 41 is cancelled, the controllable part 41 can produce elastic deformation under the action of the air pressure in the second chamber 102, so that after the air pressure acting on the controllable part 41 is cancelled, the restoring rebound force accumulated in the controllable part 41 itself can also drive the controllable part 41 to open the drug release channel 40, thereby better opening the drug release channel 40.

[0070] It is understandable that, since the controllable portion 41 is an elastically deformable part, in other embodiments, the switching of the controllable portion 41 between the closed state and the conductive state can be achieved only by controlling the increase and decrease of the air pressure in the second cavity 102. The state change of the controllable portion 41 is not controlled by the air pressure in the drug chamber 3. When the air pressure in the second cavity 102 increases, the air pressure can be applied to the controllable portion 41, and the controllable portion 41 expands and deforms in the drug release channel 40 to close the drug release channel 40. At this time, the controllable portion 41 accumulates and generates a reset rebound force after elastic deformation. As the air pressure in the second cavity 102 decreases, the controllable portion 41 can be reset and moved under the action of its own reset rebound force, thereby achieving the conduction of the drug release channel 40.

[0071] Since the controllable part 41 is not limited by the air pressure condition in the medicine chamber 3, after the controllable part 41 closes the drug release channel 40, sufficient air pressure can be pre-established in the first cavity 101 where the medicine chamber 3 is located. This air pressure can force the drug in the medicine chamber 3 to be released after the drug release channel 40 is opened, thereby achieving controlled release of the drug by simply controlling the change in air pressure in the second cavity 102.

[0072] In a specific embodiment, the controllable part 41 includes an elastic deformation film fixed on the pipe 4, and the edge of the elastic deformation film is connected and fixed to the edge of the through hole 42. As an elastic deformation film, the edge of the controllable part 41 is arranged along the edge of the through hole 42, the shape of the controllable part 41 can be arranged to match the shape of the through hole 42, and the size of the controllable part 41 can also be arranged to be slightly larger than the through hole 42. Of course, in other embodiments, the controllable part 41 can also be in a pocket shape as a whole, and the pocket mouth of the pocket is fixed to the edge of the through hole 42.

[0073] The elastic deformation film has a first side exposed toward the drug release channel, and a second side of the elastic deformation film facing away from the drug release channel 40 is exposed toward the second cavity 102. The pressurized gas pre-stored in the second cavity 102 exerts a compression effect on the second side, so that the controllable portion 41 expands and stretches toward the first side.

[0074] In the above embodiment, the controllable part 41 is fixed to the edge of the through hole 42 to achieve the sealing of the through hole 42. In other embodiments, the controllable part 41 includes an elastic tube sleeved outside the pipe 4, the elastic tube is connected and fixed to the pipe 4, and the elastic tube covers the through hole 42.

[0075] Under the action of the air pressure in the second chamber 102 , the portion of the elastic tube opposite to the through hole 42 expands and deforms toward the drug release passage 40 to close the drug release passage 40 .

[0076] In the present invention, the controllable part 41 is an elastic tube that can produce elastic deformation. After being sleeved outside the pipe 4 and fixed outside the pipe 4, the part of the elastic tube covering the through hole 42 is exposed to the second cavity 102 and is used to withstand the air pressure in the second cavity 102. After being subjected to the air pressure in the second cavity 102, it produces elastic deformation toward the drug release channel 40.

[0077] In the present invention, the through holes 42 are provided in plurality and arranged along the extension direction of the pipe 4, and a plurality of through holes 42 are provided, and a corresponding controllable portion 41 is provided at the position of each through hole 42. The plurality of controllable portions 41 are also arranged along the extension direction of the pipe 4 accordingly, and the purpose of such a design is to be able to form a closure of the drug release channel 40 at different positions, thereby realizing the control of the closure of the drug release channel 40 more stably.

[0078] It is understandable that in other embodiments, the controllable portion 41 may not produce elastic deformation, but the elastically deformable portion 41 may leave the drug release channel 40 or be folded in the drug release channel 40 through the squeezing of the drug during the drug passing through the drug release channel 40 or as the air pressure in the drug chamber 3 increases, thereby achieving the conduction of the drug release channel 40.

[0079] In a specific embodiment, the controllable portion 41 is a soft capsule disposed in the drug release channel 40, and the soft capsule 40 is communicated with the second cavity 102;

[0080] Under the action of the air pressure in the second chamber 102 , the soft capsule is supported in the drug release channel 40 to close the drug release channel; under the action of the air pressure in the drug chamber 3 , the soft capsule is folded in the drug release channel 40 to open the drug release channel 40 .

[0081] In another embodiment, if Figure 6 As shown, the controllable part 41 is a hose or an elastic tube, and the controllable part 41 has a tube body 411 and a tube hole 412 penetrating the tube body, and the tube hole 412 is a part of the drug release channel 40, and part of the elastically deformable part 41 is arranged in the second cavity 102; under the action of the air pressure in the second cavity 102, the tube body 411 contracts and deforms to close the tube hole 412. Figure 6 The dotted line indicated by 411b is a schematic diagram of the structure of the tube body 411 after shrinkage and deformation, that is, a schematic diagram of the structure in the initial state before the drug is released. Figure 6 The structure indicated by 411a is a schematic diagram of the structure of the tube body 411 before it is contracted and deformed, that is, a schematic diagram of the structure after it is reset after the drug is released.

[0082] In this embodiment, the controllable portion 41 is a part of the pipeline 4, which is a hose or an elastic tube that can be deformed after being subjected to external pressure. The extrusion deformation of the hose or the elastic tube can close the tube hole in the tube body, thereby closing the drug release channel 40. In the present invention, the pipeline 4 can be entirely a hose or an elastic tube, and of course, the pipeline 4 can also be partially a hose or an elastic tube. It should be noted that the part of the pipeline 4 that is a hose or an elastic tube needs to be located in the second cavity 102 so as to withstand the effect of the air pressure in the second cavity 102.

[0083] In the first specific embodiment, the pipeline 4 includes a first pipeline connected to the inlet 31, and the controllable part 41 connects the first pipeline with the outlet 14; it should be noted that the first pipeline is a non-elastically deformable pipe.

[0084] In a second specific embodiment, the pipeline 4 includes a second pipeline connected to the outlet 31, and the controllable part connects the inlet 31 and the second pipeline; it should be noted that the second pipeline is a non-elastically deformable pipe.

[0085] In the third specific embodiment, the pipeline 4 includes a first pipeline connected to the inlet 31 and a second pipeline connected to the outlet 14, and the controllable part 41 connects the first pipeline and the second pipeline; it should be noted that, in this embodiment, the first pipeline and the second pipeline are both non-elastically deformable pipe fittings.

[0086] In the fourth specific embodiment, the pipeline 4 as a whole is the controllable part 41 , and the controllable part 41 is connected to the inlet 31 and the outlet 14 .

[0087] In the above embodiments, the controllable part 41 is exposed to the second cavity 102 to directly bear the air pressure from the second cavity 102. In other embodiments (not shown), the controllable part 41 may not be directly disposed in the second cavity 102, that is, it may not directly bear the air pressure in the second cavity 102. The controllable part 41 bears the air pressure in the second cavity 102 indirectly.

[0088] Specifically, the drug-releasing capsule further comprises a connecting channel connecting the drug-releasing channel 40 and the second cavity 102.

[0089] The connecting channel includes a channel outlet located on the inner wall of the drug release channel and a channel inlet extending in the second cavity 102;

[0090] The controllable portion 41 is disposed at the edge of the channel outlet and closes the channel outlet, and the drug-releasing capsule further comprises a pressure-bearing deformation portion disposed at the edge of the channel inlet and closes the channel inlet;

[0091] After being acted upon by the air pressure in the second cavity 102 , the pressure-bearing deformation portion contracts or expands toward the connecting channel, and the pressure-bearing deformation portion drives the controllable portion 41 to expand and deform toward the drug release channel 40 to close the drug release channel 40 .

[0092] The drug-releasing capsule also has a pressurization channel connected to the second chamber 102 to fill the second chamber 102 with pressurized gas, and the pressurization channel includes a pressurization inlet 11 arranged on the shell 1. Filling the second chamber 102 with pressurized gas through the pressurization channel, and arranging the pressurization inlet 11 of the pressurization channel on the shell 1 can more conveniently achieve operation. It can be understood that the pressurization channel has an air inlet arranged on the shell 1 and a soft rubber plug arranged on the shell 1, and the soft rubber plug is used to block the pressurization channel after the gas filling is completed.

[0093] As a preferred solution, the soft rubber plug will form a vent after being pierced by a needle, and the soft rubber plug has a reset capability to block the vent after the needle is pulled out. When the second cavity 102 is filled with pressurized gas, the needle of the gas filling device pierces the soft rubber plug and eventually extends into the second cavity 102, and the pressurized gas is injected into the second cavity 102 from the gas filling device. After the needle of the gas filling device is pulled out, the soft rubber plug has a reset capability to re-block the vent on the soft rubber plug pierced by the syringe.

[0094] In the present invention, a partition plate 12 is provided in the shell 1, and the partition plate 12 separates the first chamber 101 and the second chamber 102. A cavity channel 120 connecting the first chamber 101 and the second chamber 102 is provided on the partition plate 12, and the valve body assembly 2 controls the opening or closing of the cavity channel 120.

[0095] In order to conveniently realize the opening or closing of the valve body assembly 2, the valve body assembly 2 includes a hot melt. In the initial state, the hot melt is in a solidified state and closes the cavity channel 120; when the hot melt is heated, the hot melt melts and opens the cavity channel 120;

[0096] In the present invention, the partition 12 divides the cavity in the housing 1 into two parts, one part is used to place the medicine chamber 3, and the other part forms an equipment cavity for placing the equipment. In a specific embodiment, the second cavity 102 can be a part of the equipment cavity, or the second cavity 102 can be the entire equipment cavity. In the present invention, the entire equipment cavity is taken as the second cavity 102 as an example for description.

[0097] The hot melt can be provided to conveniently realize the control of the opening of the cavity channel 120. When the drug-releasing capsule enters the human body, the cavity channel 120 is opened by heating the hot melt. When the hot melt is in a coagulated state, the cavity channel can be closed inside the cavity channel. As a preferred solution, the hot melt in the present invention is a hot melt film, which seals and blocks the connecting channel in a coagulated state, melts when heated, and breaks through under the action of the air pressure in the second cavity 102, thereby opening the cavity channel 120.

[0098] It is understandable that the valve body assembly 2 also has a heating element 21 disposed outside the hot melt, the heating element 21 provides heat energy to the hot melt, and the hot melt melts after receiving the heat. The heating element 21 can be an annular heating ceramic, and the heating element 21 can convert electrical energy into thermal energy, thereby causing the hot melt to deform.

[0099] It is understandable that the drug-releasing capsule also has a control module 5 disposed in the second cavity 102; the control module 5 includes a battery unit 51 and an electric control unit 52 for providing electric energy to the heating element 21, and the electric control unit 52 specifically includes a circuit board for controlling the operation of the heating element 21, a microprocessor disposed on the circuit board, and a wireless communication module. The battery unit 51 supplies power to the heating element 21, the electric control unit 52, and the wireless communication module. The wireless communication module is used to communicate with a control center outside the human body and receive instructions from the communication center. After receiving the instructions, the microprocessor controls the heating element 21 to generate heat energy to melt the hot melt. In order to conveniently realize the connection between the heating element 21 and the electric control unit 52, the electric control unit 52 and the heating element 21 are installed and matched through a plug-in assembly. The plug-in assembly includes a socket disposed on the circuit board and a pin matched with the socket, and the pin is electrically connected to the heating element 21.

[0100] Furthermore, the drug-releasing capsule also includes an imaging module 6 disposed in the second cavity 102, the imaging module 6 is electrically connected to the battery unit 51, and the imaging module 6 is used to obtain images or images of the drug-releasing capsule after entering the human body, and can use the imaging module 6 to determine whether the drug-releasing capsule has reached the designated digestive tract area, or use the imaging module 6 to identify the lesion area, and control the release of the drug in the drug chamber 3 after determining that it has reached the designated area or identified the lesion, and has the ability to release drugs visually, and can achieve more accurate controlled release of drugs. For example, when treating digestive tract ulcers, the ulcer can be accurately found through the imaging module 6, and when the drug-releasing capsule is close to the ulcer surface, the drug release is controlled to spray the drug toward the ulcer area, which is convenient for the gel drug to adhere and improve the efficacy.

[0101] Furthermore, in order to conveniently control the movement of the drug capsule in the digestive tract, a magnetic unit is also provided in the second cavity 102. The magnetic unit is arranged in the drug capsule and can use an external magnetic field to control the movement of the drug capsule in the human body, thereby better controlling the position of the drug capsule in the human body.

[0102] In the present invention, the pressurized gas is arranged in the second cavity 102, that is, the space in the second cavity 102 after deducting the valve body assembly 2, the control module 5 and the imaging module 6 can be pre-filled with pressurized gas. After the cavity channel 120 is connected, the second cavity 102 is connected to the medicine chamber 3 through the cavity channel 120. In another embodiment, a separate air bag can also be arranged in the device cavity to form the second cavity 102.

[0103] It should be noted that the housing 1 is biocompatible and will not be corroded by digestive fluid, and can be set to be transparent or opaque as needed. Since the imaging module 6 is set, the part of the housing 1 corresponding to the image acquisition area of ​​the imaging module 6 is transparent, and the above-mentioned structure is convenient for realizing the image acquisition of the imaging module 6. The image acquisition area of ​​the imaging module 6 is the range and area of ​​the image or video that the imaging module 6 can capture.

[0104] In the present invention, the imaging module 6 includes a module circuit board 61 disposed in the second cavity 102, a camera 62 disposed on the module circuit board 61, and a fill light 63 disposed beside the camera 62. The module circuit board 61 is electrically connected to the battery unit 51, and the battery unit 51 supplies power to the imaging module 6.

[0105] In order to conveniently add medicine into the medicine chamber 3, a medicine-loading soft rubber plug 13 is further provided on the housing 1, and part of the medicine-loading soft rubber plug 13 extends into the medicine chamber 3. When loading medicine into the medicine chamber 3, the medicine-loading soft rubber plug 13 is pierced by the needle of the syringe and finally extends into the medicine chamber 3, and the medicine is injected into the medicine chamber 3 from the syringe. After the needle of the syringe is pulled out, the medicine-loading soft rubber plug 13 has a reset ability to re-block the needle hole on the medicine-loading soft rubber plug 13 pierced by the syringe.

[0106] Before use, the user can use a syringe to pierce the medicine-filled soft rubber plug 13 and inject the medicine into the medicine cavity 30 of the medicine chamber 3, and at the same time add pressurized gas to the second cavity 102 through the gas filling device. Under the action of the pressurized gas in the second cavity 102, the controllable part 41 is deformed to form a closure of the drug release channel 40.

[0107] The subject eats the drug-releasing capsule, and the drug-releasing capsule is controlled to enter the designated area. The imaging module 6 is used to determine whether the drug-releasing capsule has reached the designated digestive tract area or identified the lesion. After reaching the designated area of ​​the digestive tract or identifying the lesion, a drug-releasing instruction can be sent to control the heating element 21 to melt the hot melt. After the hot melt melts, the cavity channel 120 opens, and the pressurized gas in the second cavity 102 flows into the first cavity 101 and squeezes the medicine chamber 3 to cause the drug to be ejected through the drug release channel 40. In this process, due to the decrease in the air pressure in the second cavity 102, the air pressure acting on the controllable part 41 is cancelled, and the blocking effect of the controllable part 41 on the drug release channel 40 does not exist. The drug in the medicine chamber 3 will not be hindered in the process of being released outward along the drug release channel 40, thereby allowing the drug to be released smoothly.

[0108] The above describes in detail the structure, features and effects of the present invention based on the embodiments shown in the drawings. The above is only a preferred embodiment of the present invention, but the present invention is not limited to the scope of implementation shown in the drawings. Any changes made according to the concept of the present invention, or modifications to equivalent embodiments with equivalent changes, which still do not exceed the spirit covered by the description and drawings, should be within the protection scope of the present invention.

Claims

1. A drug-releasing capsule, characterized in that: include: A housing, a first chamber and a second chamber disposed in the housing, and a valve body assembly for controlling the connection or closing of the first chamber and the second chamber; The drug-releasing capsule further comprises a drug chamber having a drug cavity, wherein the drug chamber is arranged in the first cavity and can shrink and deform after being pressurized; an inlet is arranged on the drug chamber, and an outlet is arranged on the shell, and the drug-releasing capsule comprises a pipe connecting the inlet and the outlet, and a drug-releasing channel connecting the drug cavity and the outside is formed in the pipe; The pipeline has a controllable portion, and under the action of the air pressure in the second cavity, the controllable portion is in a closed state to close the drug release channel; When the air pressure in the second chamber decreases and / or the air pressure in the drug chamber increases, the controllable part is in a conducting state of conducting the drug release channel; When the valve body assembly is opened, the gas in the second cavity flows toward the first cavity, the air pressure in the second cavity decreases, and the air pressure in the first cavity increases and squeezes the medicine chamber to increase the air pressure in the medicine chamber.

2. The drug-releasing capsule according to claim 1, characterized in that: The controllable portion is an elastically deformable part. Under the action of the air pressure in the second cavity, the controllable portion expands and deforms toward the drug release channel to close the drug release channel.

3. The drug-releasing capsule according to claim 2, characterized in that: The pipeline is provided with a through hole connecting the drug release channel and the second cavity, the controllable part covers and closes the through hole, and part of the controllable part is located in the second cavity.

4. The drug-releasing capsule according to claim 3, characterized in that: The controllable part includes an elastic deformation film fixed on the pipe, and the edge of the elastic deformation film is connected and fixed to the edge of the through hole; The elastically deformable film has a first side surface exposed toward the drug-releasing passage, and a second side surface of the elastically deformable film facing away from the drug-releasing passage is exposed toward the second cavity.

5. The drug-releasing capsule according to claim 3, characterized in that: The controllable part includes an elastic tube sleeved outside the pipeline, the elastic tube is connected and fixed to the pipeline, and the elastic tube covers the through hole; Under the action of the air pressure in the second cavity, the portion of the elastic tube opposite to the through hole expands and deforms toward the drug release channel to close the drug release channel.

6. The drug-releasing capsule according to claim 3, characterized in that: A plurality of through holes are provided and arranged along the extending direction of the pipeline.

7. The drug-releasing capsule according to claim 1, characterized in that: The controllable part is a hose or an elastic tube, which has a tube body and a tube hole passing through the tube body. The tube hole is a part of the drug release channel, and part of the tube body is arranged in the second cavity; under the action of the air pressure in the second cavity, the tube body contracts and deforms to close the tube hole.

8. The drug-releasing capsule according to claim 7, characterized in that: The pipeline includes a first pipeline communicating with the inlet, and the controllable part communicates the first pipeline with the outlet; Or the pipeline includes a second pipeline connected to the outlet, and the controllable part connects the inlet and the second pipeline; Or the pipeline includes a first pipeline communicating with the inlet and a second pipeline communicating with the outlet, and the controllable part communicates with the first pipeline and the second pipeline; Or the entire pipeline is a controllable portion, and the controllable portion connects the inlet and the outlet.

9. The drug-releasing capsule according to claim 1, characterized in that: The controllable part is a soft capsule disposed in the drug release channel, and the soft capsule is communicated with the second cavity; Under the action of the air pressure in the second chamber, the soft capsule is supported in the drug release channel to close the drug release channel; Under the action of the air pressure in the medicine chamber, the soft capsule is folded in the medicine release channel to open the medicine release channel.

10. The drug-releasing capsule according to claim 1, characterized in that: The drug-releasing capsule also has a connecting channel connecting the drug-releasing channel and the second cavity. The connecting channel comprises a channel outlet located on the inner wall of the drug release channel and a channel inlet extending in the second cavity; The controllable portion is arranged at the edge of the channel outlet and closes the channel outlet, and the drug-releasing capsule also has a pressure-bearing deformation portion arranged at the edge of the channel inlet and closes the channel inlet; After being acted upon by the air pressure in the second cavity, the pressure-bearing deformation portion contracts and deforms or expands and deforms toward the connecting channel, and the pressure-bearing deformation portion drives the controllable portion to expand and deform toward the drug release channel to close the drug release channel.

11. The drug-releasing capsule according to claim 1, characterized in that: The controllable part is an elastically deformable part. Under the action of the air pressure in the second cavity, the controllable part expands and deforms in the drug release channel to close the drug release channel. After the air pressure in the second chamber decreases, the controllable portion is reset and rebounds to open the drug release channel.

12. The drug-releasing capsule according to any one of claims 1 to 11, characterized in that: The drug-releasing capsule also has a pressurization channel communicated with the second cavity for filling the second cavity with pressurized gas, and the pressurization channel includes a pressurization inlet arranged on the shell.

13. The drug-releasing capsule according to any one of claims 1 to 11, characterized in that: A partition plate is disposed in the shell, the partition plate separates the first cavity and the second cavity, a cavity channel connecting the first cavity and the second cavity is disposed on the partition plate, and the valve body assembly controls the opening or closing of the cavity channel.

14. The drug-releasing capsule according to claim 13, characterized in that: The valve body assembly includes a hot melt. In an initial state, the hot melt is in a solidified state and closes the cavity channel. When the hot melt is heated, the hot melt melts and opens the cavity channel. The valve body assembly also has a heating element arranged outside the hot melt body, and the drug-releasing capsule also has a battery unit for providing electrical energy to the heating element, and the battery unit is arranged in the second cavity.

Images