A hydrocolloid dressing and method of manufacture thereof

Abstract

The application provides a hydrocolloid dressing and a manufacturing method thereof, which solves the technical problem that the water absorption of a single-layer hydrocolloid is not strong and the use experience is poor, and mainly comprises a substrate film, a hydrocolloid and a release layer. The substrate film is a single-layer or multi-layer structure; the hydrocolloid is a composite material, the main body of which is an adhesive and a water absorbent; and the release layer is release paper or a release film. Through the improved processing technology, the hydrocolloid with a structure of a partially semi-coated structure of water absorbent particles is obtained, so that sufficient expansion space of the water absorption material is ensured, sufficient adhesion points and activity space of the adhesive material are provided, the separation of the hydrocolloid and the substrate is reduced, the overall absorption of the permeated liquid is improved, and the application can be widely used in the technical field of medical dressings.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical dressings, in particular to a hydrocolloid dressing and a manufacturing method thereof. BACKGROUND

[0002] Traditional medical dressings are used to keep the wound dry and protect the wound. However, based on the theory of moist healing, the wound needs to be kept moist to accelerate wound healing, and thus hydrocolloid dressings have emerged and have shown obvious advantages.

[0003] Hydrocolloid dressings are generally made by mixing hydrophilic polymer particles with rubber elastomers, and are mainly used for clinical refractory wounds. They have the following advantages:

[0004] 1. The ability to absorb exudate from the wound. After absorbing the exudate, the hydrophilic particles in the dressing can form a semi-solid substance similar to a gel, which adheres to the base of the wound, providing and maintaining a moist environment conducive to wound healing;

[0005] 2. Adhesive, can form a closed wound. The closed healing environment can promote the proliferation of microvessels and the formation of granulation tissue, thereby accelerating wound healing;

[0006] 3. Can play a debridement function. On the one hand, the hydrocolloid contains endogenous enzymes that can promote the dissolution of fibrin; on the other hand, the closed environment provided by the hydrocolloid dressing is conducive to the removal of necrotic tissue by macrophages.

[0007] At present, the hydrocolloid on the market is generally composed of a single layer of material, of which the main components are adhesive and water-absorbing agent. When applied, the adhesion and water absorption must be considered, and the mixing ratio of the two main materials is particularly important. The current problem is that increasing the content of the adhesive can ensure that the material does not absorb water and swell and separate, but it can significantly reduce the water absorption capacity of the hydrocolloid; increasing the content of the water-absorbing agent can ensure the water absorption capacity of the hydrocolloid, but the adhesive capacity decreases and the dressing may separate and fall off.

[0008] Therefore, the Chinese patent CN112220960A - a double-layer hydrogel dressing and a preparation method thereof provides a multi-layer structure scheme, which mainly includes the following steps: 1, the continuous phase rubber matrix and the hydrophilic phase hydrogel are heat preserved and milled in a double-screw banbury mixer to obtain a hydrogel dressing; 2, the hydrogel dressing is pressed by a flat vulcanizing machine to form a lower base layer material; 3, the hydrogel formed by dissolving acrylic acid, gelatin, ketopiperazine, methacrylate gelatin and N-hydroxysuccinimide ester in deionized water is coated on the lower base layer material, and then the obtained double-layer hydrogel dressing is cured under ultraviolet light. The above technical scheme improves the contradiction between the bonding performance and the water absorption performance to some extent by adjusting the components and the ratio, and combining the double-layer structure, but the splicing surface of the double-layer structure is still prone to delamination, and combining the specific embodiment, it can be seen that this method increases the process flow and improves the processing cost of the dressing.

[0009] In summary, there is a need to further improve the existing hydrogel dressing structure and provide a more economical processing and manufacturing method. SUMMARY

[0010] The purpose of the present application is to solve the above technical problems, and to provide a hydrogel dressing with low cost, good water absorption and bonding performance, and a manufacturing method thereof.

[0011] To this end, the present application provides a hydrogel dressing, comprising a substrate film, a hydrogel and a release layer; the substrate film is coated with the hydrogel; the surface of the hydrogel is attached with the release layer;

[0012] The substrate film is a single-layer or multi-layer structure, and the material is one or a combination of EVA, PE, non-woven fabric, PU, TPU and PVC.

[0013] The hydrogel is a composite material, and the main material is an adhesive and CMC (carboxymethyl cellulose), and the surface of 50%-90% of the CMC particles is semi-coated with the adhesive.

[0014] The release layer is release paper or release film.

[0015] Preferably, the composite material of the hydrogel further comprises one or a combination of antioxidants and silicon dioxide.

[0016] Preferably, the surface of the substrate film is coated with a medical adhesive layer, and the medical adhesive layer is attached to the hydrogel.

[0017] Preferably, the surface of the hydrogel is provided with a dot-shaped adhesive; the dot-shaped adhesive is mainly in the form of a nail structure, the nail cap is coated or embedded on the surface of the hydrogel, and the nail tip penetrates the hydrogel and is connected to the medical adhesive layer.

[0018] In another aspect, the present application also provides a manufacturing method of a hydrocolloid dressing, characterized in that the manufacturing steps comprise:

[0019] S1, hydrocolloid preparation: uniformly stirring tackifying resin and CMC to form a first granular material, and then crushing the adhesive through an extruder to form a second granular material; and then mixing the first granular material with the second granular material to form a hydrocolloid;

[0020] S2, hydrocolloid coating: coating the hydrocolloid prepared in S1 on a substrate film, and then fixing the hydrocolloid and the substrate film through composite pressure;

[0021] S3, hydrocolloid dressing forming: attaching a release layer to the hydrocolloid to complete the shaping.

[0022] Preferably, the method comprises the following steps:

[0023] In S1, the mixing conditions of the first granular material and the second granular material are constant temperature mixing, and the temperature range is 95-110℃.

[0024] Preferably, the method comprises the following steps:

[0025] Before S2, a medical adhesive layer is formed by applying a medical adhesive on the substrate film; and the hydrocolloid is coated on the medical adhesive layer of the substrate film.

[0026] Preferably, S2 further comprises applying a point-shaped adhesive on the surface of the hydrocolloid fixed on the substrate film; and the point-shaped adhesive protrudes from the surface of the hydrocolloid.

[0027] Preferably, in S3, the point-shaped adhesive is cooled, and then the release layer is covered on the surface of the hydrocolloid and the point-shaped adhesive; the release layer surface is shaped by a pressure roller; the point-shaped adhesive is pressed into the hydrocolloid to form a nail-shaped structure, and the end of the nail-shaped structure is fixed to the medical adhesive layer.

[0028] The present application has the following advantages:

[0029] The improved processing technology of the present application can obtain a hydrocolloid with a partial semi-coating structure, which ensures sufficient expansion space for the water-absorbing material and provides sufficient attachment points and activity space for the adhesive material, thereby reducing the delamination of the hydrocolloid and the substrate and improving the overall absorption of the liquid. BRIEF DESCRIPTION OF DRAWINGS

[0030] Figure 1 is a schematic diagram of the cross section of the dressing of the present application;

[0031] Figure 2is a schematic diagram of the microstructure of the water gel of the present application and a commercially available water gel (Fig. a is a commercially available water gel, and Fig. b is the water gel of the present application);

[0032] Figure 3 is a schematic diagram of the top view structure of the present application;

[0033] Figure 4 is a schematic diagram of the point-shaped glue coating profile structure of the present application;

[0034] Figure 5 is a flow chart of the manufacturing method of the present application;

[0035] Figure 6 is a water gel cross-section electron microscope graph (Fig. c is a cross-section view of Comparative Example 1, and Fig. d is a cross-section view in the specific embodiment);

[0036] Figure 7 is a nail cap electron microscope graph in the specific embodiment of the present application;

[0037] Figure 8 is a point-shaped glue coating cross-section electron microscope graph (x40 times graph) in the specific embodiment of the present application;

[0038] Figure 9 is a point-shaped glue coating cross-section electron microscope graph (x100 times graph) in the specific embodiment of the present application;

[0039] Markings in the figure: 1. base film, 2. water gel, 3. release layer, 4. point-shaped glue coating, 201. adhesive small particles, 202. water absorbent small particles, 401. nail cap, 402. nail tip. DETAILED DESCRIPTION

[0040] The present application will be further described below in conjunction with the drawings and specific embodiments to help understand the content of the present application. The methods used in the present application are conventional methods unless otherwise specified; the raw materials and devices used are conventional commercially available products unless otherwise specified.

[0041] The present application provides a water gel dressing, as shown in Figure 1 、 2 which mainly comprises a base film 1, a water gel 2 and a release layer 3. Among them, the upper surface of the base film 1 is coated with the water gel 2, and the upper surface of the water gel 2 is attached with the release layer 3.

[0042] In the present application, the base film 1 is specifically a single-layer structure, and its material can be one of EVA (ethylene-vinyl acetate copolymer), PE (polyethylene), non-woven fabric, PU (polyurethane), TPU (thermoplastic polyurethane elastomer rubber), and PVC (polyvinyl chloride).

[0043] Preferably, in order to increase the bonding performance of the substrate film 1 and the hydrocolloid 2, increase the bonding strength with the hydrocolloid 2, so that it is not easy to delaminate after absorbing liquid, therefore, a medical adhesive layer (not shown in the figure) is designed on the upper surface of the substrate film 1, which is a medical hot melt adhesive pressure sensitive adhesive, and the formed adhesive layer is combined with the lower surface of the hydrocolloid 2.

[0044] Generally, the adhesive and the water absorbing agent and the tackifying resin are mixed very uniformly in the preparation process of the hydrocolloid dressing, so as to form two possible structures under microscopic conditions: 1, the adhesive small particles 201 completely wrap the water absorbing agent small particles 202, resulting in a serious decrease in the water absorption rate and the total water absorption amount of the water absorbing agent small particles 202 (for reference Figure 2 2, the water absorbing agent small particles completely wrap the adhesive small particles, resulting in a change in the spatial distance after the water absorbing agent small particles swell, so that the adsorption capacity of the adhesive decreases, thereby reducing the overall adhesion and causing delamination. The above two situations are formed according to the ratio of the water absorbing agent and the adhesive, and the overall microscopic display is a dense and uniform arrangement structure, so that the commercially available hydrocolloid has problems of affecting the overall water absorption rate of the hydrocolloid dressing or affecting the bonding strength after absorbing water. In summary, in order to solve the corresponding problems, the structure and material of the hydrocolloid 2 in the present application is a single layer composite material, and the main component composition is also an adhesive and a water absorbing agent, but the overall structure after processing is partially semi-coated, as shown in Figure 2 b view (the black solid area represents the adhesive, and the hollow particles are water absorbing agent particles), although a small amount of water absorbing agent small particles 202 are fully coated, the main part is the network or fork of the adhesive small particles 201 connected with the surrounding water absorbing agent particles, forming a semi-coated structure for the water absorbing agent small particles 202, wherein the semi-coated proportion is 50%-90%, and there are also pores around the water absorbing agent particles to provide sufficient liquid channels and swelling space for the water absorbing agent, and also to reduce the displacement of the adhesive during the swelling process, so as to maintain a certain bonding strength of the hydrocolloid 2.

[0045] Preferably, in the present application, the selected adhesive is also a medical hot melt pressure sensitive adhesive, which improves the connection ability with the medical adhesive layer; the water absorbing agent is CMC (carboxymethyl cellulose), and antioxidants such as alginin and silicon dioxide are added to form the required colloid together. Further, in order to increase the stability of the hydrocolloid 2 and solve the delamination problem with the substrate film 1 to a certain extent, an auxiliary fixing structure is also designed, which is a point-shaped glue coating 4 on the surface of the hydrocolloid 2, as shown in Figures 2-4 , a plurality of point-shaped glue coatings 4 are distributed on the upper surface of the hydrocolloid 2, and the main body is in the form of a nail, and the nail cap 401 is slightly embedded in the surface of the hydrocolloid 2, so that the skin does not have a significant foreign body sensation when the dressing is applied. As shown in Figure 3As shown, under the condition of top view, the nail cap 401 of the point-like glue 4 presents a circular, oval or irregular polygonal pattern due to the pressure-in, while the nail tip 402 penetrates the hydrogel 2 and connects with the medical glue layer. The above design can be popularly understood as using long nails to fix two parallel placed wooden boards, the difference is that due to the micro loose structure of the hydrogel 2, it will not excessively press the point-like glue 4 upward when absorbing liquid and expanding, causing the end to be separated from the medical glue layer, but the nail cap 401 is further embedded into the hydrogel 2 under tension, providing better stability and avoiding delamination.

[0046] The release layer 3 is a release paper or a release film, which is used to cover the main body of the hydrogel 2 and can be torn off when used.

[0047] The present application further provides a specific manufacturing method based on the aforementioned dressing, so as to realize the corresponding structure and performance, wherein the combination of Figure 5 As shown, the main manufacturing steps include:

[0048] S1, hydrogel preparation: first, uniformly stir the tackifying resin and CMC to form a first granular material, which is similar to moist sand, so that it can be extruded into a lump shape, and kneading can restore the sand state; then, break the heat capacity pressure sensitive adhesive through a screw extruder to form a second granular material, which has the same specific form as the first granular material. Then mix the first granular material with the second granular material to form a hydrogel; preferably, the mixing process adopts constant temperature mixing, and the temperature is kept between 95℃-110℃.

[0049] S2, hydrogel coating: before specific coating, first coat the medical hot melt pressure sensitive adhesive on the substrate film 1 to form a corresponding glue layer, the purpose of which is to increase the adhesion of the hydrogel 2 and the substrate film 1. The hydrogel 2 is coated on the medical glue layer of the substrate film 1 by transfer coating or direct coating, and then the hydrogel 2 and the substrate film 1 are fixed by composite pressure.

[0050] Preferably, the waterproof medical hot melt pressure sensitive adhesive is point-like and breathable on the surface of the hydrogel 2 fixed on the substrate film 1 to form a point-like glue 4 uniformly distributed on the surface. At this time, the main body of each point-like glue 4 is still in the state of protruding from the surface of the hydrogel 2. Before the next step, the waterproof medical hot melt pressure sensitive adhesive is cooled and treated to be shaped.

[0051] S3, hydrogel dressing forming: the release layer is covered on the surface of the hydrogel 2 and the point-shaped glue 4, and the surface of the release layer is heated and pushed by the pressure roller to perform hot pressing and composite shaping. At this time, the point-shaped glue 4 which is not completely hardened is pressed into the hydrogel 2 to form a nail-shaped structure, and the end penetrates the hydrogel 2 and is fixed with the medical glue layer. After hot pressing, the surface of the hydrogel 2 is smooth and smooth without protrusion, and good adhesion comfort is maintained. In this way, the point-shaped irregular glue increases the adhesion point of the contact surface with the skin, prevents the hydrogel from falling off between the hydrogel and the skin due to the decrease of adhesion after absorbing water, and has good water resistance and corrosion resistance. The hydrogel surface has no glue left area, which is beneficial to the infiltration of liquid into the hydrogel. Further, it also ensures the firm combination of the hydrogel and the base material, prevents the separation of the hydrogel and the base material after absorbing water, and maintains good liquid absorption performance.

[0052] Example 1

[0053] The components and the weight percentage of each component are as follows:

[0054] Carboxymethyl cellulose (CMC) 49%, tackifying resin 16.5%, hot melt pressure sensitive adhesive 33.5%, alginin 0.5%, silicon dioxide 0.3%, and other antioxidants 0.2%.

[0055] The main manufacturing steps in this embodiment include:

[0056] S1, hydrogel preparation: first, the tackifying resin and CMC are uniformly stirred to form a first granular material, and the mixing effect is as described above. The mixture is in the form of moist sand, which can be formed into a lump shape and can be restored to a loose sand shape by kneading. Then, the hot capacity pressure sensitive adhesive is broken by a single screw extruder and then kneaded to form a second granular material, which has the same specific form as the first granular material. Then, the first granular material and the second granular material are mixed to form a colloid, and the temperature is kept at 100°C. + 5°C.

[0057] S2, hydrogel coating: before specific coating, a medical hot melt pressure sensitive adhesive is first coated on the base film 1 to form a corresponding glue layer. The hydrogel 2 is coated on the medical glue layer of the base film 1 in a direct coating manner, and then the hydrogel 2 and the base film 1 are fixed by composite pressure. The waterproof medical hot melt pressure sensitive adhesive is point-shaped and air-permeable on the surface of the hydrogel 2 fixed on the base film 1, forming a point-shaped glue 4 uniformly distributed on the surface. The main body of each point-shaped glue 4 is still in a state of protruding from the surface of the hydrogel 2, and then natural cooling is performed.

[0058] S3, hydrogel dressing forming: the release layer is covered on the surface of the hydrogel 2 and the point-shaped glue 4, and the surface of the release layer is heated and pushed by the pressure roller to perform hot pressing and composite shaping.

[0059] Select commercially available same type product (hydrocolloid dressing single-layer composite dense structure) as comparative example for quantitative test respectively, test content as follows:

[0060] (1) Moisture absorption capacity

[0061] Test method: immerse the test sample of 25x25mm in the test liquid for 5-120 minutes, weigh the sample before and after the test and record, wherein the test temperature is 37℃.

[0062] The test results are shown in Table 1 below

[0063] Item 5 minutes 10 minutes 20 minutes 30 minutes 60 minutes 120 minutes Example 1 0.01g 0.01g 0.09g 0.08g 0.32g 0.51g Comparative Example 1 0.06g 0.06g 0.13g 0.12g 0.19g 0.37g Comparative Example 2 0 0 0.02g 0 0 0.01 g Comparative Example 3 0.01g 0.02g 0.01g 0.01g 0.01g 0.01g Comparative Example 4 0　 0　 0.02g 0　 0.03g 0.10g

[0064] Table 1

[0065] Through the test, it can be known that the liquid absorption contact area of Example 1 is relatively small due to the point-shaped glue design, so the initial short-time liquid absorption capacity is not outstanding, but it reaches 0.51g at 120 minutes, which exceeds other comparative examples.

[0066] (2) Water absorption rate

[0067] Test method: make the test sample of 25x25mm in close contact with the measuring cup, and then invert the measuring cup downward to make the test liquid in contact with the dressing for liquid absorption change, place for 24H, temperature 37℃, and weigh the sample before and after the test.

[0068] The test results are shown in Table 2 below

[0069] Item Initial weight Water absorption weight Water absorption rate (the larger the better) Example 1 2.45g 7.31g 198% Comparative Example 1 0.98g 2.00g 104% Comparative Example 2 1.06g 3.66g 245% Comparative Example 3 2.56g 3.77g 47% Comparative Example 4 2.67g 5.90g 120%

[0070] Table 2

[0071] Through the test, it can be known that the water absorption rate of the single-layer hydrocolloid structure of Example 1 is the second highest, which exceeds the 80% comparative example. Appearance detection also shows that Example 1 has no bulging phenomenon, and other comparative examples have bulging and / or delamination phenomenon.

[0072] (3) Water absorption amount

[0073] Test method: immerse the test sample of 25x25mm in the test liquid for 24H, weigh the sample before and after the test and record, which simulates the liquid absorption capacity of single-sided actual use, wherein the test temperature is 37℃.

[0074] The test results are shown in Table 3 below

[0075] Item Initial weight Water absorption weight Area (cm2) Result (the larger the better) Example 1 0.61g 3.26g 6.25 424 Comparative Example 1 0.33g 0.89g 6.25 89.6 Comparative Example 2 0.32g 1.6g 6.25 204.8 Comparative Example 3 0.86g 1.32g 6.25 73.6 Comparative Example 4 0.91g 2.59g 6.25 268.8

[0076] Table 3

[0077] It can be seen from the test that the product of Example 1 has a bottom coating, and the gel-like product after liquid absorption is also locked by the top point-like glue coating. The gel-like product does not appear to be lost, and the obtained result is the best. The appearance test also shows that the structure of Example 1 is soft and flexible, without curling phenomenon, and without bulging phenomenon. The other comparative examples respectively appear bulging and / or delamination and / or curling phenomenon.

[0078] In summary, it can be seen that the hydrocolloid dressing obtained by the application can obtain more excellent water absorption performance and better firmness, avoid delamination, curling or bulging, and significantly improve the use experience.

[0079] Further, the structure characteristics in this embodiment are verified by electron microscopy, and refer to Figure 6 . Among them, since the hydrocolloid structures of Comparative Examples 1-4 are consistent, the cross section of Comparative Example 1 is selected for observation, as shown in Figure 6 , the cross section is a uniform and dense structure, as described before, which affects the final water absorption amount and is easy to delaminate; correspondingly, the cross section of this embodiment is as shown in Figure 6 , the cross section is a loose and porous structure (microscopically presents a reticular adhesion structure), which makes it have better absorption capacity, and at the same time, the point-like glue coating 4 has better stability, reducing the delamination, as shown in Figure 7 , the single-point transfer amount of the point-like glue coating 4 is controlled, so that after hot pressing, the glue forms a columnar body, and the total height is greater than or equal to the thickness of the hydrocolloid glue layer + medical glue layer. The excess part of the length of the point-like glue forms a nail cap shape; the non-protruding part forms a nail tip shape, which strengthens the structural strength of the hydrocolloid. Among them, the nail cap 401 is as shown in Figure 7 (portion in the circle), which covers the surface layer of the hydrocolloid and is basically flush with the surface, and forms a relatively continuous surface, which will not increase the foreign body sensation of skin contact; as shown in Figure 8 (the portion in the inverted triangle circle), the nail cap 401 and the nail tip 402 form a nail-like or wedge-shaped structure embedded in the hydrocolloid, the bottom is connected with the base material layer to prevent the hydrocolloid from delaminating and falling off, combined with Figure 9 , it can be seen that the edge structure boundary is relatively clear (region at the fold line), and the point-like glue coating 4 does not diverge into the hydrocolloid, ensuring that the whole has good penetrability, which can ensure that a small amount of glue at a single point can contact and fuse with the base material film 1. This process forming is mainly due to the natural cooling of the point-like glue coating 4 before hot pressing, which reduces the situation that the nail tip 402 does not penetrate the hydrocolloid, and also reduces the amount of glue at a single point of the point-like glue coating.

[0080] In the description of the present application, it should be understood that the terms "left", "right", "upper", "lower", "top", "bottom", "front", "back", "inner", "outer", "back", "middle" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the purpose of facilitating the description of the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application.

[0081] The above is only a specific embodiment of the present application, and cannot limit the scope of the present application. Therefore, the replacement of equivalent components or equivalent changes and modifications made within the scope of the patent protection of the present application shall still fall within the scope of the claims of the present application.

Claims

1. A hydrocolloid dressing, comprising a substrate film, a hydrocolloid and a release layer; the hydrocolloid is coated on the substrate film; the surface of the hydrocolloid is attached with the release layer; characterized in that The substrate film is a single-layer or multi-layer structure, and is made of EVA, PE, non-woven fabric, PU, TPU, PVC or a combination of one or more thereof; The hydrocolloid is a composite material, and the main material is adhesive and CMC; the surface of at least part of the CMC particles is partially coated with the adhesive; the proportion of non-fully-coated CMC particles in the total CMC particles ranges from 50% to 90%; The release layer is release paper or release film.

2. A hydrocolloid dressing according to claim 1, characterised in that The composite material of the hydrocolloid further comprises one or more of an antioxidant, silicon dioxide and tackifying resin.

3. A hydrocolloid dressing according to claim 1 or 2, characterised in that The surface of the substrate film is coated with a medical adhesive layer, and the medical adhesive layer is attached to the hydrocolloid.

4. A hydrocolloid dressing according to claim 3, wherein The surface of the hydrocolloid is provided with a dot-shaped adhesive; the dot-shaped adhesive is mainly in a nail-shaped structure, and the nail cap is coated on or embedded in the surface of the hydrocolloid, and the nail tip penetrates the hydrocolloid and is connected to the medical adhesive layer.

5. A method of manufacturing a hydrocolloid dressing according to any one of claims 1-4, characterized in that, The manufacturing steps include: S1, hydrocolloid preparation: uniformly stirring tackifying resin and CMC to form a first granular material, and then extruding adhesive to form a second granular material; and then mixing the first granular material and the second granular material to form a hydrocolloid; S2, hydrocolloid coating: coating the hydrocolloid prepared in S1 on a substrate film, and then fixing the hydrocolloid to the substrate film by composite pressure; S3, hydrocolloid dressing forming: attaching a release layer to the hydrocolloid to complete the shaping.

6. A method of manufacturing a hydrocolloid dressing according to claim 5, wherein The following steps are included: In S1, the mixing conditions of the first granular material and the second granular material are constant temperature mixing, and the temperature range is 95-110°C.

7. The method of claim 5, wherein the hydrocolloid dressing is manufactured by the steps of: The following steps are included: Before S2, a medical adhesive layer is formed by coating a medical adhesive on the substrate film; and the hydrocolloid is coated on the medical adhesive layer of the substrate film.

8. The method of claim 7, wherein the water-soluble film is formed by a method comprising: In S2, the surface of the hydrocolloid fixed to the substrate film is also coated with a dot-shaped adhesive; the dot-shaped adhesive mainly protrudes from the surface of the hydrocolloid.

9. A method of manufacturing a hydrocolloid dressing according to claim 8, wherein, In S3, the dot-shaped adhesive is cooled, and then the release layer is covered on the surface of the hydrocolloid and the dot-shaped adhesive; the release layer surface is shaped by pressure roller pushing, the dot-shaped adhesive is pressed into the hydrocolloid to form a nail-shaped structure, and the end penetrates the hydrocolloid and is fixed to the medical adhesive layer.

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