Pain relief ointment and preparation method thereof

Abstract

The present application belongs to the field of medical technology, and specifically discloses a pain-relieving ointment and a preparation method thereof. The pain-relieving ointment comprises a blood-activating and detumescence-removing composition and a hydrophilic gel matrix, wherein the blood-activating and detumescence-removing composition comprises the following raw materials by weight: 26-39 parts of rhubarb, 0.9-2.5 parts of borneol, 20-25 parts of zelan, 3-6 parts of matricaria, 10-16 parts of oriental arborvitae leaves, 11-20 parts of phellodendron, 16-29 parts of menthol and 5-8 parts of camphor; the hydrophilic gel matrix comprises the following raw materials: 6-9 parts of modified starch, 25-35 parts of moisturizer, 35-45 parts of kaolin, 5-10 parts of aloe extract, 8-15 parts of citric acid, 18-26 parts of sorbic acid, 1-3 parts of alginate, and 60-80 parts of purified water. The pain-relieving ointment prepared in the present application can achieve the effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain; the components in the hydrophilic gel matrix cooperate with each other to achieve the effects of good adhesion and good skin followability.

Description

Technical Field

[0001] The present application relates to the field of medical technology, and in particular to a pain-relieving ointment and a preparation method thereof. Background Art

[0002] People often exercise or participate in sports and other activities in their lives, which not only increases the joy of life, but also helps to strengthen the body. However, if you do not warm up sufficiently before exercise or participate in activities with high intensity, the body will be bumped by external forces and prone to acute soft tissue injuries, local bleeding and inactivated cells will occur, which will cause an inflammatory reaction.

[0003] Huoxue Xiaozhong Powder is usually used for treatment, which has the effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain. The prescription of Huoxue Xiaozhong Powder includes rhubarb, zedoaria, arborvitae leaves, phellodendron and mint. Rhubarb and phellodendron can purge heat and cool blood, zedoaria can promote blood circulation, remove blood stasis, reduce swelling and relieve pain, arborvitae leaves can cool blood and stop bleeding, mint can relieve itching, relieve pain and enhance the penetration of drugs. Various components cooperate with each other to achieve the effects of promoting blood circulation, removing blood stasis, cooling blood and relieving pain.

[0004] Currently, the commonly used blood-activating and swelling-removing powder is mainly used as a gel ointment, which contains vegetable oil or animal oil combined with various medicinal components to form a colloidal substance. When used, it is applied to the injured area to exert the medicinal effect. However, when conventional ointments are used, they are applied to the affected area. The ointment is in direct contact with the outside world and is easily scratched by external objects, which greatly reduces the dosage of the ointment applied to the affected area, thereby greatly reducing the efficacy of the ointment, thereby affecting the use and treatment of the ointment. Summary of the invention

[0005] In order to improve the problem that the ointment is easily scratched by external objects during use, thereby reducing the efficacy, the present application provides a pain-relieving ointment and a preparation method thereof.

[0006] The present application provides a pain-relieving ointment, which adopts the following technical solution:

[0007] A pain relieving ointment, comprising a blood-activating and detumescence-removing composition and a hydrophilic gel matrix, wherein the blood-activating and detumescence-removing composition comprises the following raw materials, by weight: 26-39 parts of rhubarb, 0.9-2.5 parts of borneol, 20-25 parts of zedoaria, 3-6 parts of matricaria, 10-16 parts of oriental arborvitae leaves, 11-20 parts of phellodendron, 16-29 parts of menthol and 5-8 parts of camphor; the hydrophilic gel matrix comprises the following raw materials: 6-9 parts of modified starch, 25-35 parts of moisturizer, 35-45 parts of kaolin, 5-10 parts of aloe extract, 8-15 parts of

[0008] Citric acid, 18-26 parts of sorbic acid, 1-3 parts of alginate, 60-80 parts of purified water.

[0009] By adopting the above technical scheme, the components in the blood-activating and swelling-removing composition cooperate with each other and play the drug effect together, which can achieve the effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain. Among them, menthol can stimulate the mucous membrane of the skin. When used externally, it has the effects of relieving itching, anti-inflammatory and analgesic, and can also produce a local cool feeling, and has the effects of dispelling wind, clearing heat and detoxifying; camphor has the effects of clearing heat and detoxifying, stopping bleeding, reducing swelling and relieving pain, and cooperates with other components to further play the role of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain. In addition, the components in the blood-activating and swelling-removing composition cooperate with the components in the hydrophilic gel matrix to achieve the effects of good adhesion and good skin followability.

[0010] Modified starch gelatinizes after mixing with purified water. The viscosity of the gelatinized starch solution increases and it can be used as a thickener and adhesive. Kaolin has a porous structure and exhibits a strong adsorption effect. The mixture of kaolin and modified starch reduces the mutual influence between polymer chains, plays a plasticizing role, increases the cross-linking degree of the modified starch system, and increases the viscosity of the modified starch. Aloe extract not only has anti-inflammatory and bactericidal effects and antioxidant effects, but also adjusts the adhesion of the modified starch system when mixed with modified starch and kaolin. Because aloe extract The liquid has basically no viscosity. When added to the modified starch, the plasticizing effect of the mixture of modified starch and kaolin is reduced, and the viscosity of the modified starch is ensured. At the same time, the mixture of kaolin, modified starch and aloe extract allows the aloe extract to exert its anti-inflammatory and bactericidal effects and lasts for a long time. Alginate can be used as an adhesive, thickener, and emulsifier. When added to the modified starch system, the adhesiveness of the system is further increased, thereby achieving the effects of good subsequent adhesion and good skin followability, and it is not easily scratched by external objects, thereby ensuring the durability of the drug effect.

[0011] The moisturizer not only maintains the moisture of the modified starch system, but also forms a thin film on the skin surface when the ointment is used subsequently, preventing the evaporation of water in the ointment while not hindering the skin's absorption of the drug in the ointment, thereby maintaining the efficacy of the ointment and the effect of applying the ointment to the skin.

[0012] Preferably, the mass ratio of the blood-activating and swelling-removing composition to the hydrophilic gel matrix is ​​1:5-10.

[0013] By adopting the above technical scheme, the mass ratio of the blood-activating and detumescence-removing composition and the hydrophilic gel matrix is ​​limited to a certain range, so as to obtain an ointment with high viscosity and good skin adherence. The hydrophilic gel matrix enables the ointment to have good skin adherence and is not easy to be wiped off, so that the blood-activating and detumescence-removing composition can fully exert the medicinal effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain.

[0014] Preferably, the method for preparing the modified starch comprises the following steps:

[0015] (1) Grind corn starch, sieve it, disperse it in purified water, stir it evenly to obtain a suspension, add potassium permanganate solution, stir it at 55-65° C. for 10-20 minutes, and obtain a treated solution;

[0016] (2) adding malic acid and polyvinyl alcohol to the treated liquid obtained in step (1) and reacting for 30-45 minutes to obtain a mixture for later use; (3) adding polydextrose and hydroxyethyl cellulose to the mixture obtained in step (2) and stirring for 1-2 hours to obtain modified starch.

[0017] By adopting the above technical scheme, the potassium permanganate solution has strong oxidizing property and is mixed with corn starch to decompose and break the macromolecules in the structure of corn starch, and change the viscosity and fluidity of corn starch through oxidation reaction; malic acid is added, and under acidic conditions, the treated starch and polyvinyl alcohol undergo cross-linking reaction, the starch is modified when encountering malic acid, the starch particles are destroyed, the amorphous region of the branched starch is rapidly hydrolyzed, the branched structure of the amylopectin is destroyed, the content of straight-chain starch is relatively increased, and the film-forming property and strength of the corn starch are improved; polyvinyl alcohol has a relatively active hydroxyl-OH functional group, which can interact with the hydroxyl group in the starch molecular structure through hydrogen bonds to form an interpenetrating network structure, thereby improving the mechanical properties of the corn starch and making the system have better structural strength.

[0018] Polydextrose has a certain viscosity and high water absorption capacity. When added to the starch system, it interacts with the starch components to increase the viscosity of the starch. In combination with hydroxyethyl cellulose, the hydrogen bonds on the surface of the starch particles can interact with the hydrogen bonds between the hydroxyethyl cellulose molecules to form an adhesive structure, thereby making the starch particles adhere to each other. At the same time, in combination with polyvinyl alcohol, the starch system forms a three-dimensional network structure, which strengthens the adhesion between the starch particles and between the starch and other components, forming a more solid aggregate, which plays a role in thickening, bonding and stabilization, and helps to subsequently increase the viscosity of the ointment and its adhesion to the skin, and reduce the chance of the ointment being scratched.

[0019] Preferably, the mass ratio of the corn starch, malic acid and polyvinyl alcohol is 1:0.5-0.9:0.3-0.6.

[0020] By adopting the above technical scheme, the mass ratio of corn starch, malic acid and polyvinyl alcohol is controlled within a certain range, and modified starch with a high degree of cross-linking and excellent mechanical properties is obtained. The starch is modified when it encounters malic acid, the branched structure in the starch structure is destroyed, and the linear structure content of the starch is relatively increased. The polyvinyl alcohol is cross-linked with the starch to form an interpenetrating network structure, which improves the mechanical properties of the corn starch and makes the system have better structural strength.

[0021] Preferably, the mass ratio of the corn starch, polydextrose and hydroxyethyl cellulose is 1:0.1-0.3:0.2-0.5.

[0022] By adopting the above technical scheme, by limiting the mass ratio of corn starch, polydextrose and hydroxyethyl cellulose within a certain range, a modified starch with high viscosity and excellent mechanical properties is obtained. Polydextrose and hydroxyethyl cellulose are combined to increase the viscosity of starch, and starch and hydroxyethyl cellulose form an adhesive structure. In combination with polyvinyl alcohol, the starch system forms a three-dimensional network structure, which strengthens the adhesion between the starch systems. It is subsequently added to the ointment to increase the viscosity and applicability of the ointment.

[0023] Preferably, the method for preparing the aloe extract comprises the following steps:

[0024] (1) washing and peeling freshly picked aloe leaves, retaining the pulp, cutting into pieces, and then heating in a water bath at a temperature of 60-80° C., then adding sodium chloride, and continuing to stir for 30-50 minutes to obtain a mixture for later use;

[0025] (2) Dispersing the mixture obtained in step (1) in ethanol, adding chitosan and carbon fiber, stirring evenly, stirring at a temperature of 80-85° C. for 20-30 minutes, and obtaining aloe extract.

[0026] By adopting the above technical scheme, the aloe pulp is heated to increase the activity of the ingredients in the aloe pulp, and sodium chloride helps to convert the gel state in the aloe pulp into a liquid state, adjust the viscosity of the aloe, and then add chitosan, which has good antibacterial properties, degradability, biocompatibility and adsorption. The active groups in chitosan and the acidic groups in the aloe extract produce chemical bonds, hydrogen bonds and other binding forces to form a cross-linked network structure, which increases the binding force of the aloe system structure; carbon fiber has good mechanical properties, and the carbon fiber is loaded on the surface of chitosan and mixed with the aloe extract to further enhance the structural strength of the aloe system. The subsequent application in the ointment helps to increase the structural strength of the hydrophilic gel matrix, thereby helping to set the viscosity of the ointment.

[0027] Preferably, in step (1), the stirring speed is 800-1000 r / min, and in step (2), the stirring speed is 1500-1800 r / min.

[0028] By adopting the above technical solution and setting a reasonable stirring rate, it is helpful to mix the components evenly, so that the effects between the components can be brought into play later.

[0029] Preferably, the mass ratio of the mixture obtained in step (1), chitosan and carbon fiber is 1:0.1-0.5:0.01-0.03.

[0030] By adopting the above technical scheme, by limiting the mass ratio of the mixture obtained in step (1), chitosan and carbon fiber, an aloe extract with better mechanical properties is obtained, chitosan is cross-linked with the acidic groups in the aloe extract to obtain a network structure, and the carbon fiber is further mixed with chitosan and aloe extract to enhance the structural strength of the aloe system, which is helpful for the subsequent change of the structural characteristics of the ointment.

[0031] Preferably, the moisturizing agent is one or more of glycerin, olive oil, ethylene glycol, propylene glycol and polyethylene glycol.

[0032] By adopting the above technical solution, the moisturizer not only maintains the humidity of the modified starch system, but also prevents the evaporation of water in the ointment when the ointment is used subsequently, and does not hinder the skin's absorption of the drug in the ointment, thereby maintaining the efficacy of the ointment and the effect of applying the ointment to the skin.

[0033] In a second aspect, the present application also provides a method for preparing a pain-relieving ointment, comprising the following steps: preparing a hydrophilic gel matrix: mixing and stirring modified starch, a moisturizer, kaolin, aloe extract, citric acid, sorbic acid, alginate and purified water at a stirring speed of 300-500 r / min to obtain a hydrophilic gel matrix;

[0034] Preparation of a blood-activating and detumescence composition: Rhubarb, borneol, zedoaria, chamomile, arborvitae leaves, phellodendron, menthol and camphor are uniformly mixed to obtain a blood-activating and detumescence composition, and then the blood-activating and detumescence composition is added to a hydrophilic gel matrix, heated and stirred, the stirring speed is 800-1000r / min, the heating temperature is 90-95°C, and the stirring time is 3-4h to obtain a pain-relieving ointment.

[0035] By adopting the above technical solution and the above preparation method, the raw materials can be mixed evenly, the operation is simple, the processing is easy, and the subsequent industrial production is conducive.

[0036] In summary, this application has the following beneficial effects:

[0037] 1. The components in the blood-activating and swelling-removing composition of the present application cooperate with each other to exert the drug effect together, and can achieve the effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain; the components in the hydrophilic gel matrix cooperate with each other to achieve the effects of good adhesion and good skin following.

[0038] 2. In the present application, the modified starch is gelatinized after being mixed with purified water, and the viscosity of the gelatinized starch solution increases. Kaolin has a porous structure and exhibits a strong adsorption effect. The mixture of kaolin and modified starch reduces the mutual influence between polymer chains, plays a plasticizing role, increases the cross-linking degree of the modified starch system, increases the viscosity of the modified starch, and subsequently improves the viscosity of the ointment.

[0039] 3. In the present application, the aloe extract not only has anti-inflammatory and bactericidal effects and antioxidant effects, but also is mixed with modified starch and kaolin to adjust the adhesion of the modified starch system. At the same time, the mixture of kaolin, modified starch and aloe extract allows the aloe extract to exert its own anti-inflammatory and bactericidal effects and lasts for a long time, achieving the effect of good subsequent adhesion and good skin following properties, and is not easily scratched by external objects, thereby ensuring the durability of the efficacy. DETAILED DESCRIPTION

[0040] The present application is further described in detail below with reference to the embodiments.

[0041] The raw materials used in the examples and comparative examples can all be obtained from commercial sources, wherein the moisturizing agent is glycerin.

[0042] Preparation example of modified starch

[0043] Preparation Example 1-1

[0044] The preparation method of modified starch comprises the following steps:

[0045] (1) 1.5 kg of corn starch was ground through a 100-mesh sieve, then dispersed in 2.5 L of purified water and stirred evenly to obtain a suspension, 0.2 kg of potassium permanganate solution was added, and the mixture was stirred at 60° C. for 15 min to obtain a treated solution;

[0046] (2) adding malic acid and polyvinyl alcohol to the treated solution obtained in step (1) and reacting for 40 minutes to obtain a mixture for later use;

[0047] (3) Adding polydextrose and hydroxyethyl cellulose to the mixture obtained in step (2), stirring for 2 hours, to obtain modified starch; wherein the mass ratio of corn starch, malic acid and polyvinyl alcohol is 1:0.5:0.6; and the mass ratio of corn starch, polydextrose and hydroxyethyl cellulose is 1:0.3:0.5.

[0048] Preparation Example 1-2

[0049] The difference from Preparation Example 1-1 is that in step (1), malic acid is not added.

[0050] Preparation Example 1-3

[0051] The difference from Preparation Example 1-1 is that in step (2), no polyvinyl alcohol is added.

[0052] Preparation Example 1-4

[0053] The difference from Preparation Example 1-1 is that in step (3), polydextrose is not added.

[0054] Preparation Example 1-5

[0055] The difference from Preparation Example 1-1 is that in step (3), hydroxyethyl cellulose is not added.

[0056] Preparation Example 1-6

[0057] The difference from Preparation Example 1-1 is that the mass ratio of corn starch, malic acid and polyvinyl alcohol is 1:0.9:0.3.

[0058] Preparation Example 1-7

[0059] The difference from Preparation Example 1-1 is that the mass ratio of corn starch, malic acid and polyvinyl alcohol is 1:0.2:0.9.

[0060] Preparation Example 1-8

[0061] The difference from Preparation Example 1-1 is that the mass ratio of corn starch, polydextrose and hydroxyethyl cellulose is 1:0.1:0.2.

[0062] Preparation Example 1-9

[0063] The difference from Preparation Example 1-1 is that the mass ratio of corn starch, polydextrose and hydroxyethyl cellulose is 1:0.05:0.01.

[0064] Preparation Example of Aloe Extract

[0065] Preparation Example 2-1

[0066] The preparation method of aloe extract comprises the following steps:

[0067] (1) 2.0 kg of freshly picked aloe leaves were washed and peeled, the pulp was retained, and the pieces were cut into pieces, and then heated in a water bath at a temperature of 70° C., and then 0.1 kg of sodium chloride was added, and stirring was continued for 40 minutes to obtain a mixture for later use;

[0068] (2) Dispersing 1.2 kg of the mixture obtained in step (1) in 2.5 L of ethanol, adding chitosan and carbon fiber, stirring evenly, stirring at a temperature of 80° C. for 25 min, and obtaining an aloe extract; wherein, in step (1), the stirring speed is 900 r / min, and in step (2), the stirring speed is 1700 r / min; and the mass ratio of the mixture obtained in step (1), chitosan and carbon fiber is 1:0.1:0.03.

[0069] Preparation Example 2-2

[0070] The difference from Preparation Example 2-1 is that in step (2), no chitosan is added.

[0071] Preparation Example 2-3

[0072] The difference from Preparation Example 2-1 is that in step (3), no carbon fiber is added.

[0073] Preparation Example 2-4

[0074] The difference from Preparation Example 2-1 is that the mass ratio of the mixture obtained in step (1), chitosan and carbon fiber is 1:0.5:0.01.

[0075] Preparation Example 2-5

[0076] The difference from Preparation Example 2-1 is that the mass ratio of the mixture obtained in step (1), chitosan and carbon fiber is 1:0.9:0.06.

[0077] Example

[0078] Example 1

[0079] A pain relieving ointment comprises a blood-activating and detumescence-removing composition and a hydrophilic gel matrix. The blood-activating and detumescence-removing composition comprises the following raw materials by weight: 32kg of rhubarb, 1.5kg of borneol, 22kg of zedoaria, 4kg of matricaria, 13kg of oriental arborvitae leaves, 15kg of phellodendron, 22kg of menthol and 6kg of camphor; the hydrophilic gel matrix comprises the following raw materials: 7kg of modified starch, 30kg of moisturizing agent, 40kg of kaolin, 8kg of aloe extract, 12kg of citric acid, 22kg of sorbic acid, 2kg of alginate and 70kg of purified water.

[0080] The mass ratio of the blood-activating and swelling-removing composition to the hydrophilic gel matrix is ​​1:8.

[0081] The preparation method of the above-mentioned pain-relieving ointment comprises the following steps: preparing a hydrophilic gel matrix: mixing and stirring modified starch, a moisturizer, kaolin, aloe extract, citric acid, sorbic acid, alginate and purified water at a stirring speed of 400 r / min to obtain a hydrophilic gel matrix;

[0082] Preparation of a blood-activating and detumescence composition: Rhubarb, borneol, zedoaria, chamomile, arborvitae leaves, phellodendron, menthol and camphor are uniformly mixed to obtain a blood-activating and detumescence composition, and then the blood-activating and detumescence composition is added to a hydrophilic gel matrix, heated and stirred, the stirring speed is 800 r / min, the heating temperature is 90°C, and the stirring time is 3 hours to obtain a pain-relieving ointment.

[0083] The modified starch was prepared by using Preparation Example 1-1; and the aloe extract was prepared by using Preparation Example 2-1.

[0084] Example 2

[0085] A pain relieving ointment, which is different from Example 1 in that the modified starch is prepared using Preparation Example 1-2.

[0086] Example 3

[0087] A pain relieving ointment, which is different from Example 1 in that the modified starch is prepared using Preparation Examples 1-3.

[0088] Example 4

[0089] A pain relieving ointment, which is different from Example 1 in that the modified starch is prepared using Preparation Examples 1-4.

[0090] Example 5

[0091] A pain relieving ointment, which is different from Example 1 in that the modified starch is prepared using Preparation Examples 1-5.

[0092] Example 6

[0093] A pain relieving ointment, which is different from Example 1 in that the modified starch is prepared using Preparation Examples 1-6.

[0094] Example 7

[0095] A pain relieving ointment, which is different from Example 1 in that the modified starch is prepared using Preparation Examples 1-7.

[0096] Example 8

[0097] A pain relieving ointment, which is different from Example 1 in that the modified starch is prepared using Preparation Examples 1-8.

[0098] Example 9

[0099] A pain relieving ointment, which is different from Example 1 in that the modified starch is prepared using Preparation Examples 1-9.

[0100] Example 10

[0101] A pain relieving ointment, which is different from Example 1 in that the aloe extract is prepared using Preparation Example 2-2.

[0102] Embodiment 11

[0103] A pain relieving ointment, which is different from Example 1 in that the aloe extract is prepared using Preparation Example 2-3.

[0104] Example 12

[0105] A pain relieving ointment, which is different from Example 1 in that the aloe extract is prepared using Preparation Example 2-4.

[0106] Embodiment 13

[0107] A pain relieving ointment, which is different from Example 1 in that the aloe extract is prepared using Preparation Example 2-5.

[0108] Embodiment 14

[0109] A pain relieving ointment, which is different from Example 1 in that the blood-activating and detumescence-removing composition comprises the following raw materials by weight: 26kg of rhubarb, 0.9kg of borneol, 20kg of zedoaria, 3kg of matricaria, 10kg of oriental arborvitae leaves, 11kg of phellodendron, 16kg of menthol and 8kg of camphor; and a hydrophilic gel matrix comprises the following raw materials: 6kg of modified starch, 25kg of moisturizer, 35kg of kaolin, 5kg of aloe extract, 8kg of citric acid, 18kg of sorbic acid, 1kg of alginate and 60kg of purified water.

[0110] Embodiment 15

[0111] A pain relieving ointment, which is different from Example 1 in that the blood-activating and detumescence-removing composition comprises the following raw materials by weight: 39kg of rhubarb, 2.5kg of borneol, 25kg of zedoaria, 6kg of matricaria, 16kg of oriental arborvitae leaves, 20kg of phellodendron, 29kg of menthol and 5kg of camphor; and a hydrophilic gel matrix comprises the following raw materials: 9kg of modified starch, 35kg of moisturizer, 45kg of kaolin, 10kg of aloe extract, 15kg of citric acid, 26kg of sorbic acid, 3kg of alginate and 80kg of purified water.

[0112] Comparative Example

[0113] Comparative Example 1

[0114] A pain relieving ointment, which is different from Example 1 in that the blood-activating and detumescence-removing composition comprises the following raw materials by weight: 45kg of rhubarb, 0.5kg of borneol, 15kg of zedoaria, 1kg of matricaria, 5kg of oriental arborvitae leaves, 7kg of phellodendron, 12kg of menthol and 3kg of camphor; and a hydrophilic gel matrix comprises the following raw materials: 3kg of modified starch, 20kg of moisturizer, 30kg of kaolin, 1kg of aloe extract, 5kg of citric acid, 10kg of sorbic acid, 0.5kg of alginate and 50kg of purified water.

[0115] Comparative Example 2

[0116] A pain relieving ointment, which is different from Example 1 in that the blood-activating and detumescence-removing composition comprises the following raw materials by weight: 20kg of rhubarb, 8.5kg of borneol, 35kg of zedoaria, 9kg of matricaria, 18kg of oriental arborvitae leaves, 25kg of phellodendron, 33kg of menthol and 10kg of camphor; and a hydrophilic gel matrix comprises the following raw materials: 12kg of modified starch, 40kg of moisturizer, 55kg of kaolin, 15kg of aloe extract, 25kg of citric acid, 30kg of sorbic acid, 5.5kg of alginate and 90kg of purified water.

[0117] Comparative Example 3

[0118] A pain relieving ointment, which differs from Example 1 in that an equal amount of starch is used to replace the modified starch.

[0119] Comparative Example 4

[0120] A pain relieving ointment, which differs from Example 1 in that kaolin is not added.

[0121] Comparative Example 5

[0122] A pain relieving ointment, which differs from Example 1 in that no aloe extract is added.

[0123] Performance testing

[0124] The pain relieving ointments prepared in Examples 1-15 and Comparative Examples 1-5 were subjected to relevant performance tests.

[0125] Initial adhesion: refer to the 2020 edition of the Chinese Pharmacopoeia, take the ointment test sample, place it at room temperature for 30 minutes without squeezing each other, and then fix it in the center of the inclined ball rolling device with an inclination angle of 15°. Allow the steel ball to slide freely from the upper end of the inclined surface. When the steel ball is adhered to the ointment, start recording its sliding distance. The minimum distance is 20 points, and the rest are compared with it. Points will be deducted as the distance increases.

[0126] Adhesion: Take the ointment test sample and place it at room temperature for 30 minutes. Stick the test sample on the test board and place it vertically for 20 minutes. Then hang a 100g weight along the length of the test sample. If it does not fall off after 2 minutes, increase the weight to 200g or 500g. Record the time when the test sample falls off the test board. The maximum value of the recorded time and weight is 20 points. The rest are compared with it. Points will be deducted for weight and time that are less.

[0127] Peel strength: Place the ointment sample at room temperature for 30 minutes, stick the sample longitudinally to the test board, place it vertically for 20 minutes, and then hang a 100g weight 180° in the opposite direction of the length of the sample. If it does not fall off after 2 minutes, increase the weight to 200g and 500g, and record the time when the sample falls off. The maximum value of the measured weight and time (maximum peel strength) is 20 points, and the rest will be deducted points for less weight and time compared with it; the test results are shown in Table 1.

[0128] Table 1 Test data of embodiments and comparative examples

[0129] Initial adhesion Adhesion Peel strength Example 1 20 20 20 Example 2 19.2 19.1 19.0 Example 3 15 14 14 Example 4 19.3 19.2 19.1 Example 5 16 15 15 Example 6 20 19.9 20 Example 7 17.3 17.1 17.1 Example 8 20 20 19.9 Example 9 18.1 18.2 18.1 Example 10 15 14.3 14.2 Embodiment 11 16.9 16.1 16 Example 12 19.9 20 19.9 Embodiment 13 17.8 17.2 17.1 Embodiment 14 19 19.3 19.1 Embodiment 15 19 19.2 19.3 Comparative Example 1 14 13.8 13.7 Comparative Example 2 13 13.1 13.1 Comparative Example 3 11 11.1 11.3 Comparative Example 4 9.5 9.1 9.2 Comparative Example 5 10.1 10.0 10.1

[0130] As can be seen from Table 1, the ointments prepared in Examples 1, 6, 8, 12 and 14-15 of the present application have good mechanical properties and mechanical strength, and the initial adhesion, sustained adhesion and peel strength are optimally up to 20, indicating that the prepared ointment has good adhesion and peel strength, and adheres well to the skin during subsequent use, achieving a good skin followability effect.

[0131] In Example 2, malic acid is not added in the preparation method of modified starch, and polydextrose is not added in Example 4. As can be seen from Table 1, compared with Example 1, the initial adhesion, sustained adhesion and peel strength do not change much, while in Example 3, polyvinyl alcohol is not added, the initial adhesion is 15, the sustained adhesion is 14 and the peel strength is 14, and in Example 5, hydroxyethyl cellulose is not added, the initial adhesion is 16, the sustained adhesion is 15 and the peel strength is 15. Not adding polyvinyl alcohol or hydroxyethyl cellulose has a greater impact on the modified starch, thereby affecting the viscosity of the ointment in the later stage. Examples 7 and 9 change the mass ratio of corn starch, malic acid and polyvinyl alcohol and the mass ratio of corn starch, polydextrose and hydroxyethyl cellulose, respectively. As can be seen from the table, the initial adhesion, sustained adhesion and peel strength are all reduced, indicating that changes in the raw materials of each component affect the relevant properties of the modified starch.

[0132] In the preparation method of aloe extract in Example 10, chitosan is not added, and in Example 11, carbon fiber is not added. As can be seen from Table 1, compared with Example 1, the initial adhesion, sustained adhesion and peel strength are significantly reduced, indicating that chitosan and carbon fiber affect the viscosity and mechanical properties of aloe extract. In Example 13, the mass ratio of the mixture obtained in step (1), chitosan and carbon fiber is changed. As can be seen from Table 1, the measured initial adhesion, sustained adhesion and peel strength of the ointment are better than those of Examples 10-11, but worse than those of Example 1, indicating that chitosan is cross-linked with the acidic groups in the aloe extract to obtain a network structure, and the carbon fiber is further mixed with chitosan and aloe extract to enhance the viscosity of the aloe system, which is helpful for the subsequent change of the viscosity of the ointment.

[0133] Comparative Example 1-2 changes the raw material dosage of the pain-relieving ointment. As can be seen from Table 1, compared with Example 1, the initial adhesion, sustained adhesion and peel strength are significantly reduced, indicating that the ointment has better comprehensive performance according to a certain content ratio of each raw material component, and the change in the dosage of each raw material affects the mechanical properties of the pain-relieving ointment such as viscosity and peel strength.

[0134] In Comparative Example 3, an equal amount of starch is used to replace the modified starch. As can be seen from Table 1, compared with Example 1, the initial adhesion, sustained adhesion and peel strength are significantly reduced, indicating that the modified starch prepared in the present application has good strength, viscosity and peel strength, and is subsequently applied to the ointment, thereby improving the corresponding performance of the subsequent pain relief ointment.

[0135] Comparative Example 4 does not add kaolin. As can be seen from Table 1, compared with Example 1, the initial adhesion, sustained adhesion and peel strength are significantly reduced, indicating that the mixture of kaolin and modified starch reduces the mutual influence between polymer chains, plays a plasticizing role, increases the cross-linking degree of the modified starch system, and increases the viscosity of the modified starch, thereby subsequently improving the adhesion and skin follow-up of the ointment.

[0136] Comparative Example 5 does not add aloe extract. As can be seen from Table 1, compared with Example 1, the initial adhesion, sustained adhesion and peel strength are greatly reduced, indicating that the aloe extract ensures the viscosity of the modified starch. At the same time, the mixture of kaolin, modified starch and aloe extract allows the aloe extract to exert its anti-inflammatory and bactericidal effects and lasts for a long time. The subsequent application in the ointment helps to improve the viscosity of the ointment, thereby improving the adhesion of the ointment to the skin.

[0137] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A pain relieving ointment, characterized in that: The invention is prepared from a blood-activating and detumescence-removing composition and a hydrophilic gel matrix. The blood-activating and detumescence-removing composition is prepared from the following raw materials, by weight: 26-39 parts of rhubarb, 0.9-2.5 parts of borneol, 20-25 parts of zedoaria, 3-6 parts of matricaria, 10-16 parts of oriental arborvitae leaves, 11-20 parts of phellodendron, 16-29 parts of menthol and 5-8 parts of camphor; the hydrophilic gel matrix is ​​prepared from the following raw materials: 6-9 parts of modified starch, 25-35 parts of moisturizer, 35-45 parts of kaolin, 5-10 parts of aloe extract, 8-15 parts of citric acid, 18-26 parts of sorbic acid, 1-3 parts of alginate and 60-80 parts of purified water. The preparation method of the modified starch comprises the following steps: (1) Grind corn starch, sieve it, and then disperse it in purified water, stir it evenly to obtain a suspension, add potassium permanganate solution, and stir it at 55-65°C for 10-20 minutes to obtain a treated solution; (2) Add malic acid and polyvinyl alcohol to the treated solution obtained in step (1) and react for 30-45 minutes to obtain a mixture for later use; (3) adding polydextrose and hydroxyethyl cellulose to the mixture obtained in step (2), and stirring for 1-2 hours to obtain modified starch; The preparation method of the aloe extract comprises the following steps: (a) washing and peeling freshly picked aloe leaves, retaining the pulp, cutting into pieces, and then heating in a water bath at a temperature of 60-80° C., then adding sodium chloride, and continuing to stir for 30-50 minutes to obtain a mixture for later use; (b) dispersing the mixture obtained in step (a) in ethanol, adding chitosan and carbon fiber, stirring evenly, stirring at a temperature of 80-85° C. for 20-30 minutes, to obtain an aloe extract; The mass ratio of the blood-activating and swelling-removing composition to the hydrophilic gel matrix is ​​1:5-10; The mass ratio of the corn starch, malic acid and polyvinyl alcohol is 1:0.5-0.9:0.3-0.6; The mass ratio of corn starch, polydextrose and hydroxyethyl cellulose is 1:0.1-0.3:0.2-0.5; In step (a), the stirring speed is 800-1000 r / min, and in step (b), the stirring speed is 1500-1800 r / min; The mass ratio of the mixture obtained in step (a), chitosan and carbon fiber is 1:0.1-0.5:0.01-0.

03.

2. A pain relieving ointment according to claim 1, characterized in that: The moisturizing agent is one or more of glycerin, olive oil, ethylene glycol, propylene glycol and polyethylene glycol.

3. A method for preparing a pain relieving ointment according to any one of claims 1-2, characterized in that: The steps include: Preparing a hydrophilic gel matrix: mixing and stirring the modified starch, moisturizer, kaolin, aloe extract, citric acid, sorbic acid, alginate and purified water at a stirring speed of 300-500 r / min to obtain a hydrophilic gel matrix; Preparation of a blood-activating and detumescence composition: Rhubarb, borneol, zedoaria, chamomile, arborvitae leaves, phellodendron, menthol and camphor are uniformly mixed to obtain a blood-activating and detumescence composition, and then the blood-activating and detumescence composition is added to a hydrophilic gel matrix, heated and stirred, the stirring speed is 800-1000r / min, the heating temperature is 90-95°C, and the stirring time is 3-4h to obtain a pain-relieving ointment.