A filtration device for small molecule peptide production

Abstract

The application discloses a filtering device for small-molecule peptide preparation, which comprises a rack, a liquid inlet disc connected to the top of the rack through a first oil cylinder, the first oil cylinder driving the liquid inlet disc to move up and down, a plurality of raw material liquid inlet pipes and cleaning liquid flushing and recycling integrated pipes annularly connected to the liquid inlet disc, the raw material liquid inlet pipes and the cleaning liquid flushing and recycling integrated pipes being arranged at intervals, a filter disc connected to the middle of the rack through an electric turntable, a plurality of filter diaphragms annularly arranged on the filter disc, sealing pads arranged between adjacent filter diaphragms, a liquid collecting disc connected to the bottom of the rack through a second oil cylinder, the second oil cylinder driving the liquid collecting disc to move up and down, a plurality of raw material liquid collecting grooves and cleaning liquid collecting grooves annularly arranged on the liquid collecting disc, a raw material liquid output pipe connected to the raw material liquid collecting grooves, and a cleaning liquid output pipe connected to the cleaning liquid collecting grooves. The filtering device can improve the defects of the prior art, reduce the frequency of cleaning the filter membrane during shutdown, and improve the equipment startup rate.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of polypeptide preparation, and particularly relates to a filtering device for small-molecule peptide preparation. BACKGROUND

[0002] Small-molecule peptides are substances with biological activity and are widely used in cosmetics and health foods in recent years. In the preparation process of small-molecule peptides, the raw material liquid needs to be filtered. In the process of filtering the raw material liquid by the existing filtering device, the impurities accumulate on the filter membrane, and the device needs to be stopped regularly for cleaning, so that the equipment startup rate cannot be further improved. SUMMARY

[0003] The present application solves the technical problem of providing a filtering device for small-molecule peptide preparation, which can solve the shortcomings of the prior art, reduce the frequency of stopping and cleaning the filter membrane, and improve the equipment startup rate.

[0004] To solve the above technical problems, the technical solutions adopted by the present application are as follows.

[0005] A filtering device for small-molecule peptide preparation, comprising a rack, a liquid inlet disc connected to the top of the rack through a first oil cylinder, the first oil cylinder driving the liquid inlet disc to move up and down, a plurality of raw material liquid inlet pipes and cleaning liquid flushing and recycling integrated pipes connected in a ring shape on the liquid inlet disc, the raw material liquid inlet pipes and the cleaning liquid flushing and recycling integrated pipes being arranged at intervals, a filter disc connected to the middle of the rack through an electric turntable, a plurality of filter membrane pieces arranged in a ring shape on the filter disc, the filter membrane pieces corresponding one-to-one to the raw material liquid inlet pipes and the cleaning liquid flushing and recycling integrated pipes, a sealing gasket arranged between adjacent filter membrane pieces, a liquid collecting disc connected to the bottom of the rack through a second oil cylinder, the second oil cylinder driving the liquid collecting disc to move up and down, a plurality of raw material liquid collecting grooves and cleaning liquid collecting grooves arranged in a ring shape on the liquid collecting disc, a raw material liquid output pipe connected to the raw material liquid collecting grooves, and a cleaning liquid output pipe connected to the cleaning liquid collecting grooves.

[0006] Preferably, the filter disc is provided with a wedge-shaped groove frame corresponding one-to-one to the filter membrane pieces, and the filter membrane pieces are fixed in the wedge-shaped groove frame.

[0007] Preferably, two first nozzles are symmetrically arranged at the outlet of the raw material liquid inlet pipe, the spraying direction of the first nozzles is towards the inclined surface of the wedge-shaped groove frame, one second nozzle is arranged between the two first nozzles, and the spraying direction of the second nozzle is vertically downward.

[0008] As preferred, the cleaning liquid flushing and recycling integrated pipe comprises a plurality of annularly arranged recycling pipes, a first flushing pipe is arranged in the annular center formed by the recycling pipes, the length of the flushing pipe is greater than that of the recycling pipe, a rotating impeller is arranged at the outlet of the flushing pipe, a guide vane is arranged at the center of the rotating impeller, and stirring vanes are arranged at the outer side of the rotating impeller, the cleaning liquid sprayed from the flushing pipe drives the guide vanes, and the guide vanes drive the stirring vanes to stir the cleaning liquid.

[0009] As preferred, a vibration generator is arranged on the filter disc.

[0010] The beneficial effects brought by the above technical scheme are that the filtering efficiency of the present application is high, long-time filtering operation can be realized, and the starting rate is high. BRIEF DESCRIPTION OF DRAWINGS

[0011] Figure 1 is a structural diagram of one specific embodiment of the present application.

[0012] Figure 2 is a top view of the liquid inlet disc in one specific embodiment of the present application.

[0013] Figure 3 is a top view of the filter disc in one specific embodiment of the present application.

[0014] Figure 4 is a top view of the liquid collecting disc in one specific embodiment of the present application.

[0015] Figure 5 is a structural diagram of the inside of the wedge-shaped groove frame in one specific embodiment of the present application.

[0016] Figure 6 is a structural diagram of the raw material liquid inlet pipe in one specific embodiment of the present application.

[0017] Figure 7 is a structural diagram of the cleaning liquid flushing and recycling integrated pipe in one specific embodiment of the present application. DETAILED DESCRIPTION

[0018] REFERENCE Figures 1-7One specific embodiment of the present application comprises a rack 1, the top of which is connected with a liquid inlet disc 3 through a first oil cylinder 2, the first oil cylinder 2 drives the liquid inlet disc 3 to move up and down, a plurality of raw material liquid inlet pipes 4 and cleaning liquid flushing and recycling integrated pipes 5 are connected in a ring shape on the liquid inlet disc 3, the raw material liquid inlet pipes 4 and the cleaning liquid flushing and recycling integrated pipes 5 are arranged at intervals, a filter disc 7 is connected in the middle of the rack 1 through an electric turntable 6, a plurality of filter diaphragms 8 are arranged in a ring shape on the filter disc 7, the filter diaphragms 8 correspond to the raw material liquid inlet pipes 4 and the cleaning liquid flushing and recycling integrated pipes 5 one by one, sealing pads 9 are arranged between adjacent filter diaphragms 8, a liquid collecting disc 11 is connected at the bottom of the rack 1 through a second oil cylinder 10, the second oil cylinder 10 drives the liquid collecting disc 11 to move up and down, a plurality of raw material liquid collecting grooves 12 and cleaning liquid collecting grooves 13 are arranged in a ring shape on the liquid collecting disc 11, the raw material liquid collecting grooves 12 are connected with raw material liquid output pipes 14, and the cleaning liquid collecting grooves 13 are connected with cleaning liquid output pipes 15 (cleaning liquid can use pure water and other substances that do not affect the subsequent processing of raw material liquid). In the initial state, the liquid inlet disc 3, the liquid collecting disc 11 and the filter disc 7 are separated, when starting the current filtering, the liquid inlet disc 3 and the liquid collecting disc 11 press the filter disc 7, the raw material liquid inlet pipes 4 spray raw material liquid, which enters the raw material liquid collecting groove 12 after being filtered by the filter diaphragm 8, at the same time, the cleaning liquid flushing and recycling integrated pipes 5 clean the filter diaphragm 8 that is not used in the current filtering, the impurities and part of the cleaning liquid cleaned down are recycled through the cleaning liquid flushing and recycling integrated pipes 5, and the rest of the cleaning liquid filtered by the filter diaphragm 8 flows into the cleaning liquid collecting groove 13. After completing the current filtering, the liquid inlet disc 3 and the liquid collecting disc 11 are opened again, then the filter disc 7 is rotated, so that the filter diaphragm 8 used in the last round is aligned with the cleaning liquid flushing and recycling integrated pipes 5, and the filter diaphragm 8 cleaned in the last round is aligned with the raw material liquid inlet pipes 4, and the next round of filtering operation is performed. Since the filter diaphragm 8 can be cleaned in time after each use, the single use time is long, and the problem of blockage is not easy to occur.

[0019] In order to further improve the filtering and cleaning efficiency, the mounting structure of the filter membrane 8 and the corresponding raw material liquid inlet pipe 4 and cleaning liquid flushing and recycling integrated pipe 5 are optimized. The filter disc 7 is provided with a wedge-shaped groove frame 16 corresponding to the filter membrane 8, and the filter membrane 8 is fixed in the wedge-shaped groove frame 16. The outlet of the raw material liquid inlet pipe 4 is symmetrically provided with two first nozzles 17, the spraying direction of the first nozzles 17 is towards the inclined surface of the wedge-shaped groove frame 16, and a second nozzle 18 is arranged between the two first nozzles 17, and the spraying direction of the second nozzle 18 is vertically downward. The cleaning liquid flushing and recycling integrated pipe 5 includes a plurality of annularly arranged recycling pipes 19, and a first flushing pipe 20 is arranged in the annular center surrounded by the recycling pipes 19, the length of the flushing pipe 20 is greater than the length of the recycling pipe 19, a rotating impeller 21 is installed at the outlet of the flushing pipe 20, a guide vane 22 is arranged at the center of the rotating impeller 21, and an agitating vane 23 is arranged on the outer side of the rotating impeller 21. The cleaning liquid sprayed from the flushing pipe 20 drives the guide vane 22, and the guide vane 22 drives the agitating vane 23 to agitate the cleaning liquid. The filter membrane 8 is installed in a V shape in the wedge-shaped groove frame 16, the raw material liquid sprayed by the first nozzle 17 is inclined to contact the filter membrane 8 for filtering, and then the raw material liquid flows downward along the filter membrane 8, so that the contact time between the raw material liquid and the filter membrane 8 can be increased, and the second nozzle 18 sprays vertically downward to agitate the raw material liquid temporarily not passing through the filter membrane 8 and gathered at the bottom of the wedge-shaped groove frame 16, thereby accelerating the filtering efficiency of this part of the raw material liquid. The flushing pipe 20 drives the rotating impeller 21 to rotate by using the spraying kinetic energy of the cleaning liquid, and then makes the cleaning liquid flow rapidly on the surface of the filter membrane 8, thereby improving the cleaning effect of the impurities attached to the surface of the filter membrane 8. Part of the cleaning liquid will pass through the filter membrane 8 into the cleaning liquid collecting tank 13, and the remaining cleaning liquid will carry the cleaned impurities out through the recycling pipe 19.

[0020] The filter disc 7 is provided with a vibration generator 24. The vibration generator 24 generates high-frequency vibration on the filter membrane 8, which can further improve the filtering and cleaning efficiency of the filter membrane 8.

[0021] The wedge-shaped groove frame 16 and the filter disc 7 are detachably mounted, and when the filter membrane 8 in a certain wedge-shaped groove frame 16 cannot be used continuously, it can be quickly replaced, which saves time and filter membrane raw materials.

[0022] In the description of the application, it is to be understood that the terms "longitudinal", "transverse", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like are used to indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application.

[0023] The basic principles and main features of the present application and the advantages of the present application are shown and described above. It should be understood by those skilled in the art that the present application is not limited by the above examples, and the above examples and descriptions in the specification are only to illustrate the principles of the present application. Without departing from the spirit and scope of the present application, various changes and improvements can be made to the present application, and these changes and improvements all fall within the scope of the present application. The scope of protection of the present application is defined by the appended claims and their equivalents.

Claims

1. A filtration device for small molecule peptide production comprising a frame (1), characterized in that: The top of the rack (1) is connected with the liquid inlet disc (3) through the first oil cylinder (2), the first oil cylinder (2) drives the liquid inlet disc (3) to move up and down, the annular connection is provided with a plurality of raw material liquid inlet pipes (4) and cleaning liquid flushing and recycling integrated pipes (5) on the liquid inlet disc (3), the raw material liquid inlet pipes (4) and the cleaning liquid flushing and recycling integrated pipes (5) are arranged at intervals, the middle of the rack (1) is connected with the filter disc (7) through the electric rotating disc (6), a plurality of filter membranes (8) are arranged in an annular manner on the filter disc (7), the filter membranes (8) correspond to the raw material liquid inlet pipes (4) and the cleaning liquid flushing and recycling integrated pipes (5) one by one, sealing pads (9) are arranged between adjacent filter membranes (8), the bottom of the rack (1) is connected with the liquid collecting disc (11) through the second oil cylinder (10), the second oil cylinder (10) drives the liquid collecting disc (11) to move up and down, a plurality of raw material liquid collecting grooves (12) and cleaning liquid collecting grooves (13) are arranged in an annular manner on the liquid collecting disc (11), the raw material liquid collecting grooves (12) are connected with raw material liquid output pipes (14), and the cleaning liquid collecting grooves (13) are connected with cleaning liquid output pipes (15); The outlet of the raw material liquid inlet pipe (4) is symmetrically provided with two first nozzles (17), the spraying direction of the first nozzle (17) is towards the inclined surface of the wedge-shaped groove frame (16), and a second nozzle (18) is arranged between the two first nozzles (17), and the spraying direction of the second nozzle (18) is vertically downward; The cleaning liquid flushing and recycling integrated pipe (5) comprises a plurality of annularly arranged recycling pipes (19), a first flushing pipe (20) is arranged in the annular center surrounded by the recycling pipes (19), the length of the flushing pipe (20) is greater than the length of the recycling pipe (19), a rotating impeller (21) is installed at the outlet of the flushing pipe (20), a guide vane (22) is arranged at the center of the rotating impeller (21), and stirring vanes (23) are arranged on the outer side of the rotating impeller (21), the cleaning liquid sprayed from the flushing pipe (20) drives the guide vane (22), and the guide vane (22) drives the stirring vane (23) to stir the cleaning liquid.

2. The filtration device for small molecule peptide preparation of claim 1, wherein: The filter disc (7) is provided with a wedge-shaped groove frame (16) corresponding to the filter membrane (8) one by one, and the filter membrane (8) is fixed in the wedge-shaped groove frame (16).

3. The filtration device for small molecule peptide preparation of claim 1, wherein: The filter disc (7) is provided with a vibration generator (24).

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