Whole deer pill and preparation method thereof

Abstract

The invention discloses a kind of whole deer pill and its preparation method, and relates to the technical field of traditional Chinese medicine health care products. Thirty-two traditional Chinese medicines are crushed into fine powder, sieved, and mixed; 40-55 parts of refined honey are added to every 100 parts by weight of powder, and the pills are filled with an appropriate amount of water, dried, and made into water-honeyed pills; or 70-80 parts or 90-110 parts of refined honey are added to make large honey pills, and then a layer of film coating is continuously wrapped on the surface thereof, that is, obtained; the film coating comprises the following raw materials: acrylic resin, hydroxyapatite, water-soluble cellulose, and expansive auxiliary materials. The present invention disperses inorganic layered compounds in organic resins, combines fibrous substances and expansive gel substances, forms a stable three-dimensional network structure, and coats the same on the surface of pills, on the one hand, preventing active drugs from absorbing moisture and preventing moisture, and on the other hand, after the expansive auxiliary materials swell in water, a rich pore structure is formed on the surface of the pills, which can isolate the contact between taste buds and the peculiar smell of traditional Chinese medicines, and reduce the occurrence of the feeling of peculiar smell.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine health-care products, in particular to a whole deer pill and a preparation method thereof. Background Art

[0002] Quanlu Pills are a traditional Chinese medicine preparation with venison as the main ingredient. It has the effects of replenishing qi and blood, regulating menstruation and dispelling cold, nourishing the kidney and benefiting essence, nourishing yin and nourishing the skin. Deer placenta is often used as the main raw material to prepare deer placenta paste, which is a traditional Chinese medicine product that is taken directly.

[0003] Most of the existing production of Quanlu pills adopts a semi-automatic manual pill-making method, which is called the pan-pill method. This pan-pill method is to put the mother pills into a rotating water chestnut pan-pill pot, the pills roll and rub in the pot, and then intermittently spray water and sprinkle powder manually to make the mother pills gradually grow.

[0004] Traditional pills are made with honey, which easily emit the smell of Chinese medicine. Therefore, they need to be improved. Summary of the invention

[0005] The purpose of the present invention is to solve at least one of the technical problems existing in the prior art and to provide a whole deer pill and a preparation method thereof.

[0006] The technical solution of the present invention is as follows:

[0007] A method for preparing whole deer balls comprises the following raw materials in parts by weight:

[0008] 50-90 parts of dried deer; 20-60 parts of Cynomorium songaricum (fried with wine); 30-50 parts of Codonopsis pilosula; 30-50 parts of Rehmannia root; 30-50 parts of Achyranthes bidentata; 30-50 parts of Rehmannia root prepared; 30-50 parts of Cuscuta chinensis; 30-50 parts of Cuscuta chinensis; 30-50 parts of Chinese yam; 30-50 parts of Psoralea corylifolia with salt; 30-50 parts of Lycium barbarum (fried with salt water); 30-50 parts of Chuanxiong (fried with wine); 30-50 parts of Cistanche deserticola; 30-50 parts of Angelica sinensis with wine; 30-50 parts of Morinda officinalis; 30-50 parts of roasted Licorice root 0 parts; 30-50 parts of asparagus; 30-50 parts of schisandra (steamed); 30-50 parts of ophiopogon; 30-50 parts of stir-fried atractylodes; 30-50 parts of raspberry; 30-50 parts of salt eucommia; 30-50 parts of euryale; 30-50 parts of pepper; 30-50 parts of tuckahoe; 30-50 parts of dried tangerine peel; 30-50 parts of roasted astragalus; 30-50 parts of fennel (fried with wine); 30-50 parts of salted radix dipsaci; 30-50 parts of green salt; 30-50 parts of fenugreek (fried with wine); 10-30 parts of agarwood;

[0009] The above thirty-two ingredients are crushed into fine powder, sieved, and mixed; 40-55 parts of refined honey are added to every 100 parts by weight of the powder, and the mixture is made into water-honey pills with an appropriate amount of water, and dried to make water-honey pills; or 70-80 parts or 90-110 parts of refined honey are added to make large honey pills, and then a layer of film coating is applied on the surface to obtain the obtained pills;

[0010] The film coating comprises the following raw materials:

[0011] Acrylic resin, hydroxyapatite, water-soluble cellulose and swelling excipients.

[0012] As a preferred embodiment of the present invention, the expansive auxiliary material is at least one of bentonite, magnesium aluminum silicate and carbomer.

[0013] As a preferred embodiment of the present invention, the water-soluble cellulose derivative is hydroxypropyl methylcellulose, hydroxypropyl cellulose or methylcellulose.

[0014] As a preferred embodiment of the present invention, the thickness of the film coating is 1-5 μm.

[0015] As a preferred embodiment of the present invention, the mass ratio of the acrylic resin, hydroxyapatite, water-soluble cellulose and expandable auxiliary material is 7-9: 1-5: 1-10: 0.5-3.

[0016] As a preferred embodiment of the present invention, the encapsulation method is: firstly, the expandable auxiliary material and water-soluble cellulose are prepared into a solution, and the solution is sprayed on the surface of the water-honey pills or large honey pills; then, a mixed solution of hydroxyapatite and acrylic resin is prepared, and the solution is continued to be sprayed on the surface of the water-honey pills and large honey pills to obtain the product.

[0017] As a preferred embodiment of the present invention, the temperature of the spray is controlled at 50-60°C.

[0018] The invention also discloses a whole deer pill, which is prepared by any of the above preparation methods.

[0019] Whole deer jelly can replenish qi and blood and improve menstrual disorders in women;

[0020] Cynomorium songaricum (fried with wine) is sweet and warm. Cynomorium songaricum belongs to the spleen meridian, kidney meridian and large intestine meridian. It has the effect of replenishing kidney yang and is aphrodisiac. Cynomorium songaricum also has the function of benefiting essence and blood, and moistening the intestines and relieving constipation.

[0021] Codonopsis has the effects of tonifying the middle and replenishing qi, strengthening the spleen and benefiting the lungs. Codonopsis has the effects of enhancing immunity, dilating blood vessels, lowering blood pressure, improving microcirculation, and enhancing hematopoietic function.

[0022] Rehmannia root, clears away heat, cools blood, nourishes yin, and promotes the production of body fluids. It is used for fever with red tongue, thirst, yin deficiency and internal heat, bone steaming and fatigue fever, internal heat and thirst, vomiting blood, epistaxis, spots and rashes;

[0023] Rehmannia root, sweet, slightly warm, enters the heart, liver, and kidney meridians; nourishes yin and blood, replenishes essence and fills marrow. It is used for liver and kidney yin deficiency, soreness of waist and knees, bone steaming and hot flashes, night sweats and spermatorrhea, internal heat and thirst, blood deficiency and sallow complexion, palpitations, irregular menstruation, metrorrhagia, dizziness, tinnitus, and premature graying of hair;

[0024] Achyranthes bidentata, bitter, sweet, sour, neutral; enters the liver and kidney meridians, removes blood stasis and dredges the meridians, nourishes the liver and kidneys, strengthens tendons and bones, promotes urination and relieves stranguria, and guides blood downward;

[0025] Cuscuta australis seeds are sweet in taste and have the functions of nourishing the kidney and clearing the liver, improving eyesight and promoting diuresis. They are often used for symptoms such as soreness of waist and knees, asthenia and bone steaming, eye film, edema and swelling.

[0026] Cuscuta australis is sweet and warm, and enters the kidney, liver, and spleen meridians. It has the effects of nourishing the liver and kidneys, consolidating semen and reducing urination, stabilizing the fetus, improving eyesight, and stopping diarrhea.

[0027] Yam has the functions of nourishing cells, strengthening endocrine, replenishing and strengthening, and enhancing the body's hematopoietic function;

[0028] Salt-psoriasis is pungent, bitter, salty, and warm. It enters the kidney meridian and has the effect of nourishing the kidney and strengthening yang.

[0029] Lycium barbarum (fried in salt water) nourishes the liver and kidneys, improves the essence and improves eyesight. It is used for asthenia, loss of essence, soreness of waist and knees, dizziness and tinnitus, internal heat and thirst, blood deficiency and sallow complexion, and blurred vision.

[0030] Chuanxiong (fried with wine) can promote the flow of qi, remove blood stasis, dispel wind, dry dampness, promote blood circulation and relieve pain.

[0031] Cistanche deserticola tastes sweet and salty, and is warm in nature. It nourishes kidney yang, improves blood and essence, and moistens the intestines. It is used to treat kidney yang deficiency, impotence due to insufficient blood and essence, spermatorrhea, leukorrhea, frequent urination, weak legs and back pain, tinnitus, blurred vision, delayed menstruation, cold uterus and infertility, and constipation due to dry intestines.

[0032] Angelica sinensis with wine has the function of promoting blood circulation and dredge menstruation. It is used for heat-related amenorrhea, dysmenorrhea, rheumatic arthralgia, and traumatic injuries.

[0033] Morinda officinalis is pungent, sweet and slightly warm in nature. It has the effects of nourishing kidney yang, strengthening muscles and bones, and eliminating rheumatism.

[0034] Roasted licorice, licorice baked with honey, has the therapeutic effects of invigorating qi and nourishing yin, promoting yang and restoring meridians.

[0035] Asparagus cochinchinensis is cold in nature, sweet in taste and slightly bitter. It has the effects of nourishing yin, clearing away heat, moistening the lungs and nourishing the kidneys. It is used to treat yin deficiency fever, cough and vomiting blood, lung abscess, sore throat, thirst, constipation and other symptoms.

[0036] Schisandra chinensis (steamed) has the effect of nourishing the kidney and calming the mind. It is often used for long-term cough and asthma, nocturnal emission and spermatorrhea, enuresis and frequent urination, long-term diarrhea, spontaneous sweating and night sweats, thirst due to loss of body fluid, internal heat and thirst, palpitations and insomnia.

[0037] Ophiopogon japonicus tastes sweet and bitter, slightly bitter, slightly cold, and enters the lung meridian, so it is good at nourishing yin and moistening the lungs and clearing away heat. It can treat dryness and damage to lung yin, and can also be used for yin deficiency and lung heat.

[0038] Stir-fried Atractylodes macrocephala has the effects of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, stopping sweating, and calming the fetus;

[0039] Raspberry is sweet and sour in nature, and its meridians are the liver, kidney and bladder meridians. The main functions of raspberry are to nourish the kidney, consolidate the essence, reduce urine, nourish the liver and improve eyesight. It can be used clinically to treat spermatorrhea, spermatorrhea, enuresis, frequent urination, impotence, premature ejaculation, dark eyesight and blurred vision.

[0040] Salt-soaked Eucommia can strengthen the kidneys and bones, and stabilize the fetus. It can treat kidney deficiency and low back pain, impotence and spermatorrhea, fetal movement disorder, hypertension, etc.

[0041] Gorgon fruit is sweet, astringent, neutral, non-toxic, and enters the spleen and kidney meridians. It has the effects of tonifying the spleen and removing dampness, benefiting the kidney and consolidating essence, and improving hearing and eyesight.

[0042] Zanthoxylum bungeanum is pungent and hot in nature and belongs to the spleen, stomach and kidney meridians. It has the effects of warming the middle and relieving pain, killing insects and relieving itching.

[0043] Poria cocos can promote diuresis and reduce swelling, strengthen the spleen and stop diarrhea, nourish the heart and calm the mind.

[0044] Tangerine peel strengthens the spleen and appetite, regulates qi and helps digestion, dries dampness and resolves phlegm.

[0045] Roasted Astragalus, sweet, warm. Enters the lung and spleen meridians. Replenishes qi and nourishes the middle. Used for qi deficiency, fatigue, poor appetite and loose stools.

[0046] Fennel (fried with wine) has the effects of dispelling cold and relieving pain, regulating qi and stimulating appetite.

[0047] Salt-soaked Dipsacus has the effects of nourishing the liver and kidneys, promoting blood circulation and relieving pain, strengthening tendons and bones, and having anti-bacterial and anti-inflammatory effects.

[0048] Green salt belongs to the heart meridian, kidney meridian, liver meridian, lung meridian and bladder meridian. It has the effects of nourishing the kidney, clearing away heat, cooling blood and eliminating accumulation.

[0049] Fenugreek (fried with wine) has the effects of nourishing kidney yang and removing cold and dampness.

[0050] Agarwood has the effect of being pungent and warm in nature and dispelling cold, and has a good regulating effect on chest and abdominal pain.

[0051] The beneficial effects of the present invention are:

[0052] The present invention disperses inorganic layered compounds in organic resins, combines fibrous substances and expandable gel substances to form a stable three-dimensional network structure, and coats the structure on the surface of pills. On the one hand, the drug is prevented from absorbing moisture and preventing moisture. On the other hand, the excessive smell of traditional Chinese medicine can be avoided to affect the effect of taking the medicine when the patient takes the medicine. Furthermore, after the expandable auxiliary material swells in water, a structure with rich pores is formed on the surface of the pills, which can isolate the taste buds from the peculiar smell of the traditional Chinese medicine and reduce the occurrence of the peculiar smell. DETAILED DESCRIPTION

[0053] The technical solution of the present invention is further described below with reference to specific embodiments.

[0054] Example 1

[0055] A method for preparing whole deer balls, characterized by comprising the following raw materials in parts by weight:

[0056] 50 parts of whole deer; 40 parts of Cynomorium songaricum (fried with wine); 40 parts of Codonopsis pilosula; 30 parts of Rehmannia root; 40 parts of Achyranthes bidentata; 50 parts of Rehmannia root prepared; 40 parts of Cuscuta chinensis; 50 parts of Chinese yam; 40 parts of salted Psoralea corylifolia; 40 parts of Lycium barbarum (fried with salt water); 40 parts of Chuanxiong (fried with wine); 40 parts of Cistanche deserticola; 40 parts of wine-soaked Angelica sinensis; 40 parts of Morinda officinalis; 40 parts of roasted Licorice root; 30 parts of Asparagus cochinchinensis; 50 parts of Schisandra chinensis (steamed); 30 parts of Ophiopogon japonicus; 40 parts of stir-fried Atractylodes macrocephala; 40 parts of Raspberry; 50 parts of salted Eucommia ulmoides; 40 parts of Euryale ferox; 50 parts of Zanthoxylum bungeanum; 40 parts of Poria cocos; 50 parts of dried orange peel; 50 parts of roasted Astragalus membranaceus; 40 parts of fennel (fried with wine); 40 parts of salted Dipsacus asper; 40 parts of green salt; 40 parts of Fenugreek (fried with wine); 20 parts of Aquilaria sinensis;

[0057] The above thirty-two ingredients are crushed into fine powder, sieved, and mixed; 45 parts of refined honey are added to every 100 parts of powder by weight, and the mixture is made into water-honey pills with appropriate amount of water, and dried to make water-honey pills; or 80 parts of refined honey are added to make large honey pills, and then a layer of film coating is applied on the surface to obtain the obtained pills;

[0058] The film coating comprises the following raw materials:

[0059] Acrylic resin, hydroxyapatite, water-soluble cellulose and swelling excipients.

[0060] The expansive auxiliary material is bentonite and carbomer in a mass ratio of 1:1.

[0061] The water-soluble cellulose derivative is hydroxypropyl methylcellulose, hydroxypropyl cellulose or methyl cellulose.

[0062] The thickness of the film coating was 2 μm.

[0063] The mass ratio of the acrylic resin, hydroxyapatite, water-soluble cellulose and expandable auxiliary material is 7:1:1:0.5.

[0064] The encapsulation method is as follows: firstly, the expandable auxiliary material and water-soluble cellulose are prepared into a solution, and the solution is sprayed on the surface of the water-honey pills or large honey pills; then, a mixed solution of hydroxyapatite and acrylic resin is prepared, and the solution is continuously sprayed on the surface of the water-honey pills and large honey pills to obtain the product.

[0065] The temperature of the spray was controlled at 50°C.

[0066] Example 2

[0067] A method for preparing whole deer balls, characterized by comprising the following raw materials in parts by weight:

[0068] 60 parts of whole deer; 60 parts of Cynomorium songaricum (fried with wine); 30 parts of Codonopsis pilosula; 30 parts of Rehmannia root; 30 parts of Cyathula; 50 parts of Rehmannia root prepared; 30 parts of Cuscuta chinensis; 35 parts of Cuscuta chinensis; 40 parts of Dioscorea opposita; 40 parts of salt Psoralea corylifolia; 50 parts of Lycium barbarum (fried with salt water); 35 parts of Chuanxiong (fried with wine); 35 parts of Cistanche deserticola; 40 parts of wine Angelica sinensis; 40 parts of Morinda officinalis; 50 parts of roasted Licorice root; 50 parts of Asparagus cochinchinensis; 50 parts of Schisandra chinensis (steamed); 50 parts of Ophiopogon japonicus; 50 parts of stir-fried Atractylodes macrocephala; 35 parts of Raspberry; 30 parts of salt Eucommia ulmoides; 30 parts of Euryale ferox; 35 parts of Zanthoxylum bungeanum; 40 parts of Poria; 40 parts of Tangerine peel; 40 parts of roasted Astragalus membranaceus; 45 parts of Fennel (fried with wine); 40 parts of Salt Dipsacus asper; 45 parts of Green Salt; 45 parts of Fenugreek (fried with wine); 20 parts of Aquilaria sinensis;

[0069] The above thirty-two ingredients are crushed into fine powder, sieved, and mixed; 40-55 parts of refined honey are added to every 100 parts of powder by weight, and the mixture is made into water-honey pills with appropriate amount of water, and dried to make water-honey pills; or 90 parts of refined honey are added to make large honey pills, and then a layer of film coating is applied on the surface to obtain the obtained pills;

[0070] The film coating comprises the following raw materials:

[0071] Acrylic resin, hydroxyapatite, water-soluble cellulose and swelling excipients.

[0072] The expansive auxiliary material is bentonite and carbomer in a mass ratio of 1:2.

[0073] The water-soluble cellulose derivative is hydroxypropyl methylcellulose.

[0074] The thickness of the film coating was 3 μm.

[0075] The mass ratio of the acrylic resin, hydroxyapatite, water-soluble cellulose and expandable auxiliary material is 9:1:1:0.7.

[0076] The encapsulation method is as follows: firstly, the expandable auxiliary material and water-soluble cellulose are prepared into a solution, and the solution is sprayed on the surface of the water-honey pills or large honey pills; then, a mixed solution of hydroxyapatite and acrylic resin is prepared, and the solution is continuously sprayed on the surface of the water-honey pills and large honey pills to obtain the product.

[0077] The temperature of the spray was controlled at 55°C.

[0078] Example 3

[0079] A method for preparing whole deer balls, characterized by comprising the following raw materials in parts by weight:

[0080] 70 parts of whole deer; 50 parts of Cynomorium songaricum (fried with wine); 40 parts of Codonopsis pilosula; 30 parts of Rehmannia root; 35 parts of Achyranthes bidentata; 35 parts of Rehmannia root prepared; 35 parts of Cuscuta chinensis; 45 parts of Cuscuta chinensis; 50 parts of Chinese yam; 50 parts of salted Psoralea corylifolia; 50 parts of Lycium barbarum (fried with salt water); 45 parts of Chuanxiong (fried with wine); 45 parts of Cistanche deserticola; 35 parts of wine-scented Angelica sinensis; 45 parts of Morinda officinalis; 45 parts of roasted Licorice root; 40 parts of Asparagus cochinchinensis; 40 parts of Schisandra chinensis (steamed); 40 parts of Ophiopogon japonicus; 40 parts of stir-fried Atractylodes macrocephala; 40 parts of Raspberry; 40 parts of salted Eucommia ulmoides; 35 parts of Euryale ferox; 35 parts of Zanthoxylum bungeanum; 40 parts of Poria cocos; 35 parts of dried orange peel; 35 parts of roasted Astragalus membranaceus; 40 parts of fennel (fried with wine); 38 parts of salted Dipsacus asper; 41 parts of green salt; 42 parts of Fenugreek (fried with wine); 28 parts of Aquilaria sinensis;

[0081] The above thirty-two ingredients are crushed into fine powder, sieved, and mixed; 45 parts of refined honey are added to every 100 parts of powder by weight, and the mixture is made into water-honey pills with appropriate amount of water, and dried to make water-honey pills; or 110 parts of refined honey are added to make large honey pills, and then a layer of film coating is applied on the surface to obtain the obtained pills;

[0082] The film coating comprises the following raw materials:

[0083] Acrylic resin, hydroxyapatite, water-soluble cellulose and swelling excipients.

[0084] The expansive auxiliary material is magnesium aluminum silicate and carbomer in a mass ratio of 1:2.

[0085] The water-soluble cellulose derivative is hydroxypropyl methylcellulose.

[0086] The thickness of the film coating was 4 μm.

[0087] The mass ratio of the acrylic resin, hydroxyapatite, water-soluble cellulose and expandable auxiliary material is 8:3:5:1.

[0088] The encapsulation method is as follows: firstly, the expandable auxiliary material and water-soluble cellulose are prepared into a solution, and the solution is sprayed on the surface of the water-honey pills or large honey pills; then, a mixed solution of hydroxyapatite and acrylic resin is prepared, and the solution is continuously sprayed on the surface of the water-honey pills and large honey pills to obtain the product.

[0089] The temperature of the spray was controlled at 60°C.

[0090] Example 4

[0091] A method for preparing whole deer balls, characterized by comprising the following raw materials in parts by weight:

[0092] 90 parts of whole deer; 20 parts of Cynomorium songaricum (fried with wine); 30 parts of Codonopsis pilosula; 50 parts of Rehmannia root; 32 parts of Achyranthes bidentata; 36 parts of Rehmannia root prepared; 39 parts of Cuscuta chinensis; 34 parts of Cuscuta chinensis; 42 parts of Chinese yam; 44 parts of salted Psoralea corylifolia; 45 parts of Lycium barbarum (fried with salt water); 46 parts of Chuanxiong (fried with wine); 47 parts of Cistanche deserticola; 39 parts of wine-scented Angelica sinensis; 38 parts of Morinda officinalis; 39 parts of roasted Licorice root; 35 parts of Asparagus cochinchinensis; 50 parts of Schisandra chinensis (steamed); 50 parts of Ophiopogon japonicus; 40 parts of stir-fried Atractylodes macrocephala; 40 parts of Raspberry; 40 parts of Salted Eucommia ulmoides; 40 parts of Euryale ferox; 45 parts of Zanthoxylum bungeanum; 40 parts of Poria cocos; 50 parts of Tangerine peel; 40 parts of roasted Astragalus membranaceus; 40 parts of Fennel (fried with wine); 35 parts of Salted Dipsacus asper; 45 parts of Green Salt; 35 parts of Fenugreek (fried with wine); 28 parts of Aquilaria sinensis;

[0093] The above thirty-two ingredients are crushed into fine powder, sieved, and mixed; 45 parts of refined honey are added to every 100 parts of powder by weight, and the mixture is made into water-honey pills with appropriate amount of water, and dried to make water-honey pills; or 75 parts of refined honey are added to make large honey pills, and then a layer of film coating is applied on the surface to obtain the obtained pills;

[0094] The film coating comprises the following raw materials:

[0095] Acrylic resin, hydroxyapatite, water-soluble cellulose and swelling excipients.

[0096] The expansive auxiliary materials are bentonite, magnesium aluminum silicate and carbomer in a mass ratio of 1:1:1.

[0097] The water-soluble cellulose derivative is hydroxypropyl cellulose.

[0098] The thickness of the film coating was 5 μm.

[0099] The mass ratio of the acrylic resin, hydroxyapatite, water-soluble cellulose and expandable auxiliary material is 9:1:1:2.

[0100] The encapsulation method is as follows: firstly, the expandable auxiliary material and water-soluble cellulose are prepared into a solution, and the solution is sprayed on the surface of the water-honey pills or large honey pills; then, a mixed solution of hydroxyapatite and acrylic resin is prepared, and the solution is continuously sprayed on the surface of the water-honey pills and large honey pills to obtain the product.

[0101] The temperature of the spray was controlled at 60°C.

[0102] Example 5

[0103] A method for preparing whole deer balls, characterized by comprising the following raw materials in parts by weight:

[0104] 80 parts of dried deer; 50 parts of Cynomorium songaricum (fried with wine); 40 parts of Codonopsis pilosula; 50 parts of Rehmannia root; 36 parts of Achyranthes bidentata; 34 parts of Rehmannia root prepared; 34 parts of Cuscuta chinensis; 33 parts of Cuscuta chinensis; 36 parts of Dioscorea opposita; 30 parts of Psoralea corylifolia with salt; 35 parts of Lycium barbarum (fried with salt water); 38 parts of Chuanxiong (fried with wine); 39 parts of Cistanche deserticola; 34 parts of Angelica sinensis with wine; 30-50 parts of Morinda officinalis; 30-50 parts of roasted Licorice root 0 parts; 30-50 parts of asparagus; 30-50 parts of schisandra (steamed); 32 parts of ophiopogon; 35 parts of stir-fried atractylodes; 34 parts of raspberry; 34 parts of salt eucommia; 38 parts of euryale; 39 parts of prickly ash; 32 parts of tuckahoe; 44 parts of dried tangerine peel; 47 parts of roasted astragalus; 48 parts of fennel (fried with wine); 50 parts of salted radix dipsaci; 48 parts of green salt; 44 parts of fenugreek (fried with wine); 17 parts of agarwood;

[0105] The above thirty-two ingredients are crushed into fine powder, sieved, and mixed; 40-55 parts of refined honey are added to every 100 parts of powder by weight, and the mixture is made into water-honey pills with appropriate amount of water, and dried to make water-honey pills; or 70 parts of refined honey are added to make large honey pills, and then a layer of film coating is applied on the surface to obtain the obtained pills;

[0106] The film coating comprises the following raw materials:

[0107] Acrylic resin, hydroxyapatite, water-soluble cellulose and swelling excipients.

[0108] The expansive auxiliary material is magnesium aluminum silicate and carbomer in a mass ratio of 1:4.

[0109] The water-soluble cellulose derivative is hydroxypropyl cellulose.

[0110] The thickness of the film coating was 4 μm.

[0111] The mass ratio of the acrylic resin, hydroxyapatite, water-soluble cellulose and expandable auxiliary material is 9:1:3:3.

[0112] The encapsulation method is as follows: firstly, the expandable auxiliary material and water-soluble cellulose are prepared into a solution, and the solution is sprayed on the surface of the water-honey pills or large honey pills; then, a mixed solution of hydroxyapatite and acrylic resin is prepared, and the solution is continuously sprayed on the surface of the water-honey pills and large honey pills to obtain the product.

[0113] The temperature of the spray was controlled at 50°C.

[0114] Comparative Example 1 (no coating)

[0115] A method for preparing whole deer balls, characterized by comprising the following raw materials in parts by weight:

[0116] 80 parts of dried deer; 50 parts of Cynomorium songaricum (fried with wine); 40 parts of Codonopsis pilosula; 50 parts of Rehmannia root; 36 parts of Achyranthes bidentata; 34 parts of Rehmannia root prepared; 34 parts of Cuscuta chinensis; 33 parts of Cuscuta chinensis; 36 parts of Dioscorea opposita; 30 parts of Psoralea corylifolia with salt; 35 parts of Lycium barbarum (fried with salt water); 38 parts of Chuanxiong (fried with wine); 39 parts of Cistanche deserticola; 34 parts of Angelica sinensis with wine; 30-50 parts of Morinda officinalis; 30-50 parts of roasted Licorice root 0 parts; 30-50 parts of asparagus; 30-50 parts of schisandra (steamed); 32 parts of ophiopogon; 35 parts of stir-fried atractylodes; 34 parts of raspberry; 34 parts of salt eucommia; 38 parts of euryale; 39 parts of prickly ash; 32 parts of tuckahoe; 44 parts of dried tangerine peel; 47 parts of roasted astragalus; 48 parts of fennel (fried with wine); 50 parts of salted radix dipsaci; 48 parts of green salt; 44 parts of fenugreek (fried with wine); 17 parts of agarwood;

[0117] The above 32 ingredients are crushed into fine powder, sieved and mixed evenly; add 40-55 parts of refined honey to every 100 parts by weight of powder, mix with appropriate amount of water to make pills, dry and make water-honey pills; or add 70 parts of refined honey to make large honey pills.

[0118] Comparative Example 2 (coating without swelling excipients)

[0119] A method for preparing whole deer balls, characterized by comprising the following raw materials in parts by weight:

[0120] 80 parts of dried deer; 50 parts of Cynomorium songaricum (fried with wine); 40 parts of Codonopsis pilosula; 50 parts of Rehmannia root; 36 parts of Achyranthes bidentata; 34 parts of Rehmannia root prepared; 34 parts of Cuscuta chinensis; 33 parts of Cuscuta chinensis; 36 parts of Dioscorea opposita; 30 parts of Psoralea corylifolia with salt; 35 parts of Lycium barbarum (fried with salt water); 38 parts of Chuanxiong (fried with wine); 39 parts of Cistanche deserticola; 34 parts of Angelica sinensis with wine; 30-50 parts of Morinda officinalis; 30-50 parts of roasted Licorice root 0 parts; 30-50 parts of asparagus; 30-50 parts of schisandra (steamed); 32 parts of ophiopogon; 35 parts of stir-fried atractylodes; 34 parts of raspberry; 34 parts of salt eucommia; 38 parts of euryale; 39 parts of prickly ash; 32 parts of tuckahoe; 44 parts of dried tangerine peel; 47 parts of roasted astragalus; 48 parts of fennel (fried with wine); 50 parts of salted radix dipsaci; 48 parts of green salt; 44 parts of fenugreek (fried with wine); 17 parts of agarwood;

[0121] The above thirty-two ingredients are crushed into fine powder, sieved, and mixed; 40-55 parts of refined honey are added to every 100 parts of powder by weight, and the mixture is made into water-honey pills with appropriate amount of water, and dried to make water-honey pills; or 70 parts of refined honey are added to make large honey pills, and then a layer of film coating is applied on the surface to obtain the obtained pills;

[0122] The film coating comprises the following raw materials:

[0123] Acrylic resin, hydroxyapatite, water-soluble cellulose.

[0124] The water-soluble cellulose derivative is hydroxypropyl cellulose.

[0125] The thickness of the film coating was 4 μm.

[0126] The mass ratio of the acrylic resin, hydroxyapatite and water-soluble cellulose is 9:1:3.

[0127] The encapsulation method is as follows: firstly, water-soluble cellulose is prepared into a solution, and the solution is sprayed on the surface of water-honey pills or large honey pills; then, a mixed solution of hydroxyapatite and acrylic resin is prepared, and the solution is continuously sprayed on the surface of water-honey pills and large honey pills to obtain the product.

[0128] The temperature of the spray was controlled at 50°C.

[0129] The water vapor permeability of the above examples and comparative examples was evaluated and tested. The test results are shown in Table 1.

[0130] Table 1 Performance test results of embodiments and comparative examples

[0131]

[0132]

[0133] It can be seen from the above table that the performance of the embodiment is better than that of the comparative example. The main reasons may be as follows: in the embodiment, the inorganic layered compound is dispersed in the organic resin, combined with the fibrous substance and the expandable gel substance to form a stable three-dimensional network structure, which is coated on the surface of the pill. On the one hand, it prevents the drug from absorbing moisture and moisture-proofing, and on the other hand, it can avoid the excessive taste of traditional Chinese medicine affecting the taking effect when the patient takes it. Moreover, after the expandable auxiliary material swells in water, a rich pore structure is formed on the surface of the pill, which can isolate the taste buds from the contact with the peculiar smell of traditional Chinese medicine and reduce the occurrence of the feeling of peculiar smell.

[0134] Under the premise that no conflict occurs, those skilled in the art may freely combine and superimpose the above-mentioned additional technical features.

[0135] The above description is only a preferred embodiment of the present invention. Any technical solution that achieves the purpose of the present invention by substantially the same means belongs to the protection scope of the present invention.

Claims

1. A method for preparing whole deer balls, characterized in that: Made from the following raw materials in parts by weight: 50-90 parts of dried deer; 20-60 parts of Cynomorium songaricum stir-fried with wine; 30-50 parts of Codonopsis pilosula; 30-50 parts of Rehmannia root; 30-50 parts of Achyranthes bidentata; 30-50 parts of Rehmannia root prepared; 30-50 parts of Cuscuta chinensis; 30-50 parts of Chinese yam; 30-50 parts of Psoralea corylifolia with salt; 30-50 parts of Lycium barbarum stir-fried with salt water; 30-50 parts of Chuanxiong stir-fried with wine; 30-50 parts of Cistanche deserticola; 30-50 parts of Angelica sinensis with wine; 30-50 parts of Morinda officinalis; 30-50 parts of roasted Licorice root; 30-50 parts of Asparagus cochinchinensis; 30-50 parts of steamed Schisandra chinensis; 30-50 parts of Ophiopogon japonicus; 30-50 parts of stir-fried Atractylodes macrocephala; 30-50 parts of Rubus idaeus; 30-50 parts of salted Eucommia ulmoides; 30-50 parts of Euryale ferox; 30-50 parts of Zanthoxylum bungeanum; 30-50 parts of Poria cocos; 30-50 parts of dried orange peel; 30-50 parts of roasted Astragalus membranaceus; 30-50 parts of fennel fried with wine; 30-50 parts of salted Dipsacus asper; 30-50 parts of green salt; 30-50 parts of fenugreek fried with wine; 10-30 parts of agarwood; The above thirty-two ingredients are crushed into fine powder, sieved and mixed; 40-55 parts of refined honey are added to every 100 parts of powder by weight, and the mixture is made into water-honey pills with appropriate amount of water, and dried to make water-honey pills; or 70-80 parts or 90-110 parts of refined honey are added to make large honey pills, and then a film coating is applied on the surface to obtain the obtained pills; The film coating is made from the following raw materials: Acrylic resin, hydroxyapatite, water-soluble cellulose and swelling excipients; The encapsulation method is as follows: firstly, a swelling auxiliary material and water-soluble cellulose are prepared into a solution, and the solution is sprayed on the surface of water-honeyed pills or large honeyed pills; then, a mixed solution of hydroxyapatite and acrylic resin is prepared, and the solution is continuously sprayed on the surface of water-honeyed pills and large honeyed pills to obtain the obtained film; the swelling auxiliary material is at least one of bentonite, magnesium aluminum silicate, and carbomer; the water-soluble cellulose derivative is hydroxypropyl methylcellulose, hydroxypropyl cellulose, or methyl cellulose; the thickness of the film coating is 1-5 μm; the mass ratio of the acrylic resin, hydroxyapatite, water-soluble cellulose, and swelling auxiliary material is 7-9:1-5:1-10:0.5-3; and the temperature of the spray is controlled at 50-60°C.

2. A whole deer ball, characterized in that: The method is as claimed in claim 1.

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