A production device for fusidic acid sodium salt

Abstract

The present invention provides a production device for sodium fusidic acid, comprising a salt-forming reaction tank, a material transfer pump, a liquid filter, a reflux crystallizer, a centrifuge, a mother liquor distillation tank, a solvent collection tank, a solvent delivery pump, and a reflux water separator. The device can effectively recover and recycle the solvent, without consuming the solvent and at a low cost. When the reflux crystallizer and the mother liquor distillation tank are heating, a certain vacuum is applied to the reflux crystallizer and the mother liquor distillation tank via a vacuum main pipe, thereby lowering the boiling point, saving energy required for heating, and saving costs. After the heating is completed, nitrogen is then filled via a back-pressure pipe to return the pressure to normal.

Description

Technical Field

[0001] The present invention relates to the technical field of production of sodium fusidic acid, and in particular to a production device of sodium fusidic acid. Background Art

[0002] Since fusidic acid is insoluble in water, its clinical use is subject to certain restrictions, while sodium fusidate is easily soluble in water and lower alcohols and has been widely used in clinical practice.

[0003] The structure of sodium fusidate is as follows:

[0004]

[0005] Chinese patent CN112979739A discloses a method for producing sodium fusidate by crystallization using a mixed organic solvent of lower alcohol and dichloromethane.

[0006] Chinese patent CN103214540A discloses the crystallization production of sodium fusidate using lower alcohol and ethyl acetate as a mixed organic solvent.

[0007] Chinese patent CN103012536A discloses that acetone and water, which cannot form an azeotropic phase with water, are used as a mixed solvent for the crystallization production of sodium fusidate. This consumes a large amount of acetone, which is difficult to recycle and reuse.

[0008] The above patents all involve dissolving fusidic acid in a water-soluble solvent or a mixed solvent thereof with water, adding an alkaline solution for reaction, and then adding a non-water-soluble solvent for mixed organic solvent crystallization to obtain sodium fusidate.

[0009] The above preparation processes all have the following disadvantages: a mixed organic solvent phase is formed during the crystallization process; a large amount of organic solvent is used, separation and recovery are difficult, and the production cost is high. Summary of the Invention

[0010] The invention provides a production device for sodium fusidic acid, which solves the problems of large amount of organic solvent used, difficulty in separation and recovery, and high cost in the production process of sodium fusidic acid by existing equipment.

[0011] The technical solution of the present invention is achieved as follows:

[0012] A production device for sodium fusidic acid comprises a salt-forming reaction tank, a material transfer pump, a liquid filter, a reflux crystallization tank, a centrifuge, a mother liquor distillation tank, a solvent collection tank, a solvent delivery pump, and a reflux water separator; the upper portion of the salt-forming reaction tank comprises a feeding port I, the outer peripheral side of which is wrapped with a jacket I for introducing a medium to achieve temperature regulation, the bottom of which comprises a discharge port I, and the interior of the salt-forming reaction tank comprises a stirring device I; the upper portion of the reflux crystallization tank comprises a feeding port II, a solvent circulation inlet, a steam outlet I, and a reflux inlet, the outer peripheral side of which is wrapped with a jacket II for introducing a medium to achieve temperature regulation, the bottom of which comprises a discharge port II, and the interior of the reflux crystallization tank comprises a stirring device I. Device II; the discharge port I and the feed port II are connected by a pipeline I, and the pipeline I is connected in sequence with a control valve I, a transfer pump, a liquid filter and a control valve II; the centrifuge includes a feed port III and a liquid outlet; the discharge port II and the feed port III are connected by a pipeline III, and the pipeline III is connected with a control valve III; the upper part of the mother liquid distillation tank includes a feed port IV and a steam outlet II, the bottom includes a wastewater discharge port, the outer peripheral side is wrapped with a jacket III for introducing a medium to achieve temperature regulation, and the interior of the mother liquid distillation tank includes a stirring device III; the liquid outlet and the feed port IV are connected by a pipeline IV, and the pipeline IV is connected to a control valve IV, and the wastewater discharge port is connected to a wastewater control valve; the upper part of the solvent collection tank includes a liquid inlet I, and the bottom includes a discharge port V; the upper part of the mother liquor distillation tank and / or the solvent collection tank includes an air pressure port I, the air pressure port I is connected to an air pressure control valve I, and the air pressure control valve I is connected to an air pressure pipe; the steam outlet II and the liquid inlet I are connected through a steam pipe I, and the steam pipe I is connected to a condenser I; the discharge port V is connected to a drain pipe I and a circulation pipe, the drain pipe I is connected to a drain control valve I, the other end of the circulation pipe is connected to the solvent circulation inlet, and the circulation pipe is sequentially connected to the control valve V, a solvent delivery pump and a control valve VI; The upper part of the flow water separator includes a liquid inlet II, the bottom includes a drain outlet, and the upper and middle part of the side has a reflux outlet; the steam outlet I and the liquid inlet II are connected by a steam pipe II, the steam pipe II is connected to a condenser II, the drain outlet is connected to a drain control valve II, and the reflux outlet is connected to the reflux inlet through a reflux pipe; the top of the reflux water separator and / or the reflux crystallization tank includes an air pressure port II, the air pressure port II is connected to an air pressure control valve II, and the air pressure control valve II is connected to an air pressure pipe; the air pressure pipe is connected to a vacuum main pipe for evacuation and a back pressure pipe for intake back pressure, the vacuum main pipe is connected to a vacuum control valve, and the back pressure pipe is connected to the back pressure control valve.

[0013] Furthermore, the salt-forming reaction tank also includes a temperature measuring device I for measuring temperature.

[0014] Furthermore, the reflux crystallization tank and the mother liquor distillation tank both include a temperature measuring device II for measuring temperature, the reflux crystallization tank and the mother liquor distillation tank are also connected to a gas pressure gauge, and the circulation pipe is connected to a liquid pressure gauge.

[0015] Furthermore, the drainage control valve II is connected to a wastewater metering tank, and the bottom of the wastewater metering tank is connected to a drainage control valve III.

[0016] Furthermore, the return pipe includes a U-shaped water trap.

[0017] Furthermore, the return pipe, between the drain port and the drain control valve II, and the drain pipe I all include sight glasses for observation.

[0018] Furthermore, the feeding port I includes a liquid feeding port and a solid feeding port.

[0019] Furthermore, the jacket I includes an inlet I and an outlet I, the jacket II includes an inlet II and an outlet II, and the jacket III includes an inlet III and an outlet III.

[0020] Furthermore, the stirring device I includes a stirring motor I, a reducer I, a stirring shaft I and a stirring blade I, one end of the stirring shaft I is located in the salt-forming reaction tank and is fixedly connected to the stirring blade I on the side, and one end of the stirring shaft I is located outside the salt-forming reaction tank and is connected to the stirring motor I through the reducer I; the jacket II includes an inlet II and an outlet II, the stirring device II includes a stirring motor II, a reducer II, a stirring shaft II and a stirring blade II, one end of the stirring shaft II is located in the salt-forming reaction tank and is fixedly connected to the stirring blade II on the side, and one end of the stirring shaft II is located outside the salt-forming reaction tank and is connected to the stirring motor II through the reducer II; the jacket III includes an inlet III and an outlet III, the stirring device III includes a stirring motor III, a reducer III, a stirring shaft III and a stirring blade III, one end of the stirring shaft III is located in the salt-forming reaction tank and is fixedly connected to the stirring blade III on the side, and one end of the stirring shaft III is located outside the salt-forming reaction tank and is connected to the stirring motor III through the reducer III.

[0021] Furthermore, the control valve I, control valve II, control valve III, control valve IV, control valve V, control valve VI, air pressure control valve I, air pressure control valve II, drainage control valve I, drainage control valve II, vacuum control valve, and back pressure control valve are all automatic control valves.

[0022] The beneficial effects of the present invention are as follows: the device of the present invention can effectively recover the solvent and recycle it, without consuming the solvent and with low cost; when the reflux crystallization tank and the mother liquor distillation tank are heating, the reflux crystallization tank and the mother liquor distillation tank are vacuumed to a certain extent through the vacuum main pipe, which can reduce the boiling point, save the energy required for heating, and save costs; after the heating work is completed, nitrogen is filled through the back-pressure pipe to return to normal pressure. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0024] Figure 1 It is a structural schematic diagram of the present invention.

[0025] In the figure: 1, salt-forming reaction tank, 2-jacket I, 3-stirring device I, 4-liquid feeding port, 5-solid feeding port, 6-temperature measuring device I, 7-control valve I, 8-pipeline I, 9-transfer pump, 10-liquid filter, 11-control valve II, 12-reflux crystallization tank, 13-stirring device II, 14-jacket II, 15-control valve III, 16-pipeline III, 17-centrifuge, 18-pipeline IV, 19-control valve IV, 20-mother liquor distillation tank, 21-jacket III, 22-stirring device III, 23-wastewater control valve, 24-steam pipe I, 25-condenser I, 26-Solvent collection tank, 27-Sight glass, 28-Drain pipe I, 29-Drain control valve I, 30-Control valve V, 31-Circulation pipe, 32-Solvent delivery pump, 33-Liquid pressure gauge, 34-Control valve VI, 35-U-trap, 36-Steam pipe II, 37-Reflux pipe, 38-Reflux water distributor, 39-Drain control valve II, 40-Wastewater metering tank, 41-Drain control valve III, 42-Air pressure pipe, 43-Pressure control valve II, 44-Air pressure control valve I, 45-Vacuum main pipe, 46-Vacuum control valve, 47-Back pressure pipe, 48-Back pressure control valve, 49-Condenser II. DETAILED DESCRIPTION

[0026] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0027] Reference Figure 1A production device for sodium fusidic acid salt includes a salt-forming reaction tank 1, a transfer pump 9, a liquid filter 10, a reflux crystallization tank 12, a centrifuge 17, a mother liquor distillation tank 20, a solvent collection tank 26, a solvent delivery pump 32 and a reflux water separator 38; the upper part of the salt-forming reaction tank 1 includes a feeding port I, the outer peripheral side is wrapped with a jacket I2 for introducing a medium to achieve temperature regulation, the bottom has a discharge port I, and the interior of the salt-forming reaction tank 1 includes a stirring device I3; the upper part of the reflux crystallization tank 12 includes a feeding port II, a solvent circulation inlet, a steam outlet I and a reflux inlet, the outer peripheral side is wrapped with a jacket II14 for introducing a medium to achieve temperature regulation, the bottom includes a discharge port II, and the interior of the reflux crystallization tank 12 includes a stirring device II1 3; the discharge port I and the feed port II are connected by a pipeline I8, and the pipeline I8 is sequentially connected with a control valve I7, a transfer pump 9, a liquid filter 10 and a control valve II11; the centrifuge 17 includes a feed port III and a liquid outlet; the discharge port II and the feed port III are connected by a pipeline III16, and the pipeline III16 is connected with a control valve III15; the upper part of the mother liquid distillation tank 20 includes a feed port IV and a steam outlet II, and the bottom includes a wastewater discharge port. The outer peripheral side is wrapped with a jacket III21 for introducing a medium to achieve temperature regulation, and the interior of the mother liquid distillation tank 20 includes a stirring device III22; the liquid outlet and the feed port IV are connected by a pipeline IV18, and the pipeline IV18 is connected with a control valve Valve IV19, the wastewater discharge port is connected to the wastewater control valve 23; the upper part of the solvent collection tank 26 includes a liquid inlet I, and the bottom includes a discharge port V; the upper part of the mother liquor distillation tank 20 and / or the solvent collection tank 26 includes an air pressure port I, the air pressure port I is connected to the air pressure control valve I44, and the air pressure control valve I is connected to the air pressure pipe 42; the steam outlet II and the liquid inlet I are connected through a steam pipe I24, and the steam pipe I24 is connected to a condenser I25; the discharge port V is connected to a drain pipe I28 and a circulation pipe 31, the drain pipe I28 is connected to a drain control valve I29, and the other end of the circulation pipe 31 is connected to the solvent circulation inlet, and the circulation pipe 31 is sequentially connected to a control valve V30, a solvent delivery pump 32 and a control valve VI34; reflux The upper part of the water separator 38 includes a liquid inlet II, the bottom includes a drain outlet, and the upper and middle part of the side has a reflux outlet; the steam outlet I and the liquid inlet II are connected by a steam pipe II36, the steam pipe II36 is connected to the condenser II49, the drain outlet is connected to the drain control valve II39, and the reflux outlet is connected to the reflux inlet through the reflux pipe 37; the top of the reflux water separator 38 and / or the reflux crystallization tank 12 includes an air pressure port II, the air pressure port II is connected to the air pressure control valve II43, and the air pressure control valve II is connected to an air pressure pipe 42; the air pressure pipe 42 is connected to a vacuum main pipe 45 for evacuation and a back pressure pipe 47 for intake back pressure, the vacuum main pipe 45 is connected to a vacuum control valve 46, and the back pressure pipe 47 is connected to a back pressure control valve 48.

[0028] Furthermore, the salt-forming reaction tank 1 also includes a temperature measuring device 16 for measuring temperature.

[0029] Furthermore, the reflux crystallization tank 12 and the mother liquor distillation tank 20 both include a temperature measuring device II for measuring temperature, the reflux crystallization tank 12 and the mother liquor distillation tank 20 are also connected to a gas pressure gauge, and the circulation pipe 31 is connected to a liquid pressure gauge 33.

[0030] Furthermore, the drainage control valve II39 is connected to a wastewater metering tank 40 , and the bottom of the wastewater metering tank 40 is connected to a drainage control valve III41 .

[0031] Furthermore, the return pipe 37 includes a U-shaped water trap 35 .

[0032] Furthermore, a sight glass 27 for observation is included on the return pipe 37, between the drain port and the drain control valve II39, and on the drain pipe I28.

[0033] Furthermore, the feeding port I includes a liquid feeding port 4 and a solid feeding port 5.

[0034] Furthermore, the jacket I2 includes an inlet I and an outlet I, the jacket II14 includes an inlet II and an outlet II, and the jacket III21 includes an inlet III and an outlet III.

[0035] Furthermore, the stirring device I3 includes a stirring motor I, a reducer I, a stirring shaft I and a stirring blade I, one end of the stirring shaft I is located in the salt-forming reaction tank 1 and is fixedly connected to the side with the stirring blade I, one end of the stirring shaft I is located outside the salt-forming reaction tank 1 and is connected to the stirring motor I through the reducer I; the jacket II13 includes an inlet II and an outlet II, the stirring device II includes a stirring motor II, a reducer II, a stirring shaft II and a stirring blade II, one end of the stirring shaft II is located in the salt-forming reaction tank 1 and is fixedly connected to the side with the stirring blade II, one end of the stirring shaft II is located outside the salt-forming reaction tank 1 and is connected to the stirring motor II through the reducer II; the jacket III22 includes an inlet III and an outlet III, the stirring device III includes a stirring motor III, a reducer III, a stirring shaft III and a stirring blade III, one end of the stirring shaft III is located in the salt-forming reaction tank 1 and is fixedly connected to the side with the stirring blade III, one end of the stirring shaft III is located outside the salt-forming reaction tank 1 and is connected to the stirring motor III through the reducer III.

[0036] Furthermore, the control valve I7, control valve II11, control valve III15, control valve IV19, control valve V30, control valve VI34, air pressure control valve I44, air pressure control valve II43, drain control valve I29, drain control valve II39, vacuum control valve 46, and back pressure control valve 48 are all automatic control valves.

[0037] Working principle of the present invention:

[0038] Purified water is added through the liquid feeding port 4, the stirring device I3 is started, cooling water is introduced into the inlet I of the jacket I2, and a base is added through the solid feeding port 5, and then fusidic acid is added until the reaction is complete and clarified; the control valve I7 and the control valve II11 are opened, the transfer pump 9 is started, the salt solution is transported to the reflux crystallizer 12, the control valve V30 and the control valve VI34 are opened, the solvent delivery pump 32 is started to transport the organic solvent from the solvent collection tank 26 (the solvent collection tank is previously stored with an organic solvent) to the reflux crystallizer 12, the stirring device II13 is started to stir, the vacuum main 45 is connected to a vacuum pump, the vacuum control valve 46 and the air pressure control valve II43 are opened, the vacuum pump is started to vacuumize, and the reflux is reduced. The air pressure in the crystallizer 12 is reduced, the boiling point is saved, the energy required for heating is saved, the cost is saved, the vacuum degree is controlled to be less than or equal to -0.085Mpa, the inlet II of the jacket II14 is fed into the hot water circulation heating, the reflux crystallizer 12 is heated, the steam generated by the heating of the liquid in the reflux crystallizer 12 is condensed into a liquid by the condenser II49 and then enters the reflux water separator 38, the condensed liquid in the reflux water separator 38 comprises an organic solvent and water, the organic solvent is in the upper strata, and the water is in the lower floor, the organic solvent on the upper strata enters the reflux crystallizer 12 by the reflux pipe 37, the water on the lower floor is discharged into the waste water metering tank 40 by the drain control valve II39 for metering, after the heating is completed, the back pressure control valve 48 and the air pressure control valve II43 are opened, and the back pressure control valve 48 and the air pressure control valve II43 are opened. Nitrogen is introduced into the pressure pipe 47 to return to normal pressure for cooling and crystallization. Cold water is circulated into the inlet II of the jacket II14 for cooling. After the cooling and crystallization is completed, the control valve III15 is opened and the crystal porridge is discharged into the centrifuge 17 for centrifugation to separate the solid and the liquid to obtain fusidic acid sodium salt tidal crystals and a liquid mother liquor, respectively. The fusidic acid sodium salt tidal crystals are subsequently vacuum dried to become the finished product; the air pressure control valve I44 is opened and the vacuum pump is started to vacuumize. Under the action of atmospheric pressure, the mother liquor in the centrifuge 17 is pressed into the mother liquor distillation tank 20 through the pipeline IV18. Vacuuming can reduce the air pressure in the mother liquor distillation tank 20, reduce the boiling point, save the energy required for heating, save costs, and the vacuum degree is controlled to be ≤-0.08 5Mpa, start stirring device III22 to stir, hot water is introduced into the inlet III of jacket III21 for circulation heating, the steam generated by heating is condensed into liquid by condenser II25 and enters solvent collecting tank 26, the condensed liquid includes organic solvent and water, and the organic solvent is in the upper layer after standing, and the water is in the lower layer. The wastewater layer is drained by standing, and the water control valve I29 is opened to drain the water in the lower layer through the drain pipe I28, leaving the organic solvent in the upper layer. The recovered organic solvent is re-delivered to the reflux crystallizer 12 by the solvent delivery pump 32 for recycling of the next batch production. After the heating of the mother liquor distillation tank 20 is completed, the back pressure control valve 48 and the air pressure control valve I44 are opened, and nitrogen is passed through the back pressure pipe 47 to return to normal air pressure.

[0039] The device of the present invention can effectively recover the solvent and recycle it, does not consume the solvent, and has low cost. When the reflux crystallization tank and the mother liquor distillation tank are heating, the reflux crystallization tank and the mother liquor distillation tank are vacuumed to a certain extent through the vacuum main pipe, which can reduce the boiling point, save the energy required for heating, and save costs. After the heating work is completed, nitrogen is filled through the back-pressure pipe to return to normal pressure.

[0040] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A production device for fusidic acid sodium salt, characterized in that: It includes a salt-forming reaction tank, the upper part includes a feeding port I, the outer peripheral side is wrapped with a jacket I for introducing a medium to achieve temperature regulation, the bottom has a discharge port I, and the interior of the salt-forming reaction tank includes a stirring device I; The reflux crystallizer includes a feed port II, a solvent circulation inlet, a steam outlet I and a reflux inlet at the top, a jacket II wrapped around the outer periphery for introducing a medium to achieve temperature regulation, a discharge port II at the bottom, and a stirring device II inside the reflux crystallizer; The discharge port I and the feed port II are connected by a pipeline I, and the pipeline I is sequentially connected with a control valve I, a material transfer pump, a liquid filter and a control valve II; a centrifuge, comprising a feed port III and a liquid outlet; The discharge port II and the feed port III are connected via a pipeline III, and the pipeline III is connected to a control valve III; A mother liquor distillation tank, comprising a feed port IV and a steam outlet II at the top, a wastewater outlet at the bottom, a jacket III wrapped around the outer periphery for introducing a medium to achieve temperature regulation, and a stirring device III inside the mother liquor distillation tank; The liquid outlet and the feed port IV are connected via a pipe IV, a control valve IV is connected to the pipe IV, and the wastewater discharge port is connected to a wastewater control valve; The solvent collection tank includes a liquid inlet I at the top and a discharge port V at the bottom; The upper portion of the mother liquid distillation tank and / or the solvent collection tank includes an air pressure port I, the air pressure port I is connected to an air pressure control valve I, and the air pressure control valve I is connected to an air pressure pipe; The steam outlet II and the liquid inlet I are connected via a steam pipe I, and the steam pipe I is connected to a condenser I; The discharge port V is connected to a drain pipe I and a circulation pipe, the drain pipe I is connected to a drain control valve I, the other end of the circulation pipe is connected to the solvent circulation inlet, and the circulation pipe is sequentially connected to a control valve V, a solvent delivery pump and a control valve VI; A reflux manifold, comprising a liquid inlet II at the top, a drain outlet at the bottom, and a reflux outlet at the upper middle portion of the side; The steam outlet I and the liquid inlet II are connected via a steam pipe II, the steam pipe II is connected to a condenser II, the drain outlet is connected to a drain control valve II, and the reflux outlet is connected to the reflux inlet via a reflux pipe; The top of the reflux water separator and / or the reflux crystallization tank includes an air pressure port II, the air pressure port II is connected to an air pressure control valve II, and the air pressure control valve II is connected to an air pressure pipe; The air pressure pipe is connected to a vacuum main pipe for vacuuming and a back pressure pipe for intake back pressure, the vacuum main pipe is connected to a vacuum control valve, and the back pressure pipe is connected to a back pressure control valve; The salt-forming reaction tank also includes a temperature measuring device I for measuring temperature; The feeding port I includes a liquid feeding port and a solid feeding port.

2. The production device of fusidic acid sodium salt according to claim 1, characterized in that: The reflux crystallization tank and the mother liquor distillation tank both include a temperature measuring device II for measuring temperature. The reflux crystallization tank and the mother liquor distillation tank are also connected to a gas pressure gauge, and the circulation pipe is connected to a liquid pressure gauge.

3. The production device of fusidic acid sodium salt according to claim 1, characterized in that: The drainage control valve II is connected to a wastewater metering tank, and the bottom of the wastewater metering tank is connected to a drainage control valve III.

4. The production device of fusidic acid sodium salt according to claim 1, characterized in that: The return pipe includes a U-shaped water trap.

5. The production device of fusidic acid sodium salt according to claim 1, characterized in that: The return pipe, between the drain port and the drain control valve II, and the drain pipe I all include sight glasses for observation.

6. The production device of fusidic acid sodium salt according to claim 1, characterized in that: The jacket I includes an inlet I and an outlet I, the jacket II includes an inlet II and an outlet II, and the jacket III includes an inlet III and an outlet III.

7. The production device of fusidic acid sodium salt according to claim 1, characterized in that: The stirring device 1 includes a stirring motor 1, a reducer 1, a stirring shaft 1 and a stirring blade 1, one end of the stirring shaft 1 is located in the salt-forming reaction tank and is fixedly connected to the side with the stirring blade 1, and one end of the stirring shaft 1 is located outside the salt-forming reaction tank and is connected to the stirring motor 1 through the reducer 1; The jacket II includes an inlet II and an outlet II, and the stirring device II includes a stirring motor II, a reducer II, a stirring shaft II and a stirring blade II. One end of the stirring shaft II is located in the salt-forming reaction tank and is fixedly connected to the side of the stirring blade II. One end of the stirring shaft II is located outside the salt-forming reaction tank and is transmission-connected to the stirring motor II through the reducer II. The jacket III includes an inlet III and an outlet III, and the stirring device III includes a stirring motor III, a reducer III, a stirring shaft III and a stirring blade III. One end of the stirring shaft III is located in the salt-forming reaction tank and is fixedly connected to the side with the stirring blade III. One end of the stirring shaft III is located outside the salt-forming reaction tank and is transmission-connected to the stirring motor III through the reducer III.

8. The production device of fusidic acid sodium salt according to claim 1, characterized in that: The control valve I, control valve II, control valve III, control valve IV, control valve V, control valve VI, air pressure control valve I, air pressure control valve II, drainage control valve I, drainage control valve II, vacuum control valve and back pressure control valve are all automatic control valves.

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