Pharmaceutical composition for treating diabetes

Abstract

A pharmaceutical composition for treating diabetes, prepared from the following Chinese medicinal raw materials in parts by weight: 30-120 parts of astragalus, 30-50 parts of codonopsis, 30-50 parts of polygonatum, 60-120 parts of trichosanthes, 30-50 parts of pueraria, 30-50 parts of coptis, 10-30 parts of atractylodes, 30-80 parts of raw yam, 10-30 parts of euryale, 5-20 parts of dried ginger, 30-60 parts of chicken gizzard lining, and 10-20 parts of raw semi-arid 10-30 parts of summer mulberry, 10-30 parts of white silkworm, 10-30 parts of vinegar bupleurum, 10-30 parts of scutellaria, 10-30 parts of vinegar cyperus, 10-30 parts of costusroot, 5-20 parts of amomum, 30-80 parts of raw rehmannia, 20-80 parts of wine taro meat, 20-50 parts of peony bark, 5-20 parts of leech, 15-30 parts of chuanxiong, 10-30 parts of salt phellodendron, 10-30 parts of cinnamon, and 10 parts of cooked pu'er tea.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, and in particular to a pharmaceutical composition for treating diabetes. Background Art

[0002] Diabetes is a disease name in traditional Chinese medicine. It refers to a complex disease characterized by polydipsia, polyuria, polyphagia, weight loss, fatigue, and sweet urine. Modern medicine considers it to be a chronic metabolic disease. Currently, medicine believes that only hypoglycemic drugs can be used to maintain blood sugar stability and reduce complications.

[0003] For example, the drugs used in Western medicine may cause the following problems: 1. Insulin: The adverse reactions of insulin include: (1) Allergic reactions. Patients who use insulin may experience urticaria and angioedema at the injection site; (2) Hypoglycemia reaction; (3) Insulin resistance; (4) Subcutaneous fat atrophy or hyperplasia at the injection site; (5) Refractive disorders. 2. Sulfonylureas: Adverse reactions of sulfonylureas: Occasionally, hypoglycemia may occur. There may be diarrhea, nausea, vomiting, headache, stomach pain or discomfort. Rashes are less common. Rare but serious reactions include jaundice, liver damage, granulocytopenia (manifested as sore throat, fever, infection), thrombocytopenia (manifested as bleeding, purpura), etc. 3. Biguanides: The most common adverse reactions of biguanides are: gastrointestinal reactions, manifested as loss of appetite, nausea, vomiting, diarrhea, stomach pain, metallic taste in the mouth, etc. Sometimes patients experience fatigue, tiredness, weight loss, dizziness and rash. 4. Dietary glucose regulators: Adverse reactions of dietary glucose regulators include: hypoglycemia, visual abnormalities, gastrointestinal reactions, allergic rashes, itching and urticaria. A very small number of patients experience elevated liver transaminases, which are mild and transient and rarely lead to drug discontinuation. 5. Thiazolidinediones insulin sensitizers: Adverse reactions of thiazolidinediones insulin sensitizers include: (1) anemia; (2) cardiovascular system reactions; (3) neuropsychiatric system reactions; (4) hypoglycemia reactions; (5) gastrointestinal reactions, etc. 6. Non-insulin glucose-lowering hormone drugs: Non-insulin glucose-lowering hormone drugs also have some adverse reactions, among which nausea is the most common. Severe hypoglycemia events are likely to occur within 3 hours after use. Patients may also experience anorexia, vomiting, fatigue and dizziness.

[0004] At present, the commonly used Chinese patent medicines for the treatment of diabetes are mainly the following: (1) Xiaoke Pills; (2) Jiangtangshu; (3) Yuquan Pills; (4) Jiangtangjia Tablets; (5) Ganlu Xiaoke Capsules; (6) Liuwei Dihuang Pills and Maiwei Dihuang Pills; (7) Shihu Yeguang Pills; (8) Mingmu Dihuang Pills; (9) Shenqi Jiangtang Tablets; (10) Kelening Capsules; (11) Xiaokeling Tablets; (12) Jinqi Jiangtang Tablets; (13) Tangmaikang Granules; (14) Shibawei Terminalia Ziliure Pills. Despite this, the efficacy of these Chinese medicine preparations is still unsatisfactory. Summary of the invention

[0005] In view of this, it is necessary to provide a pharmaceutical composition with better efficacy for treating diabetes.

[0006] A pharmaceutical composition for treating diabetes, prepared from the following Chinese medicinal raw materials in parts by weight: 30-120 parts of astragalus, 30-50 parts of codonopsis, 30-50 parts of polygonatum, 60-120 parts of trichosanthes, 30-50 parts of pueraria, 30-50 parts of coptis, 10-30 parts of atractylodes, 30-80 parts of raw yam, 10-30 parts of euryale, 5-20 parts of dried ginger, 30-60 parts of chicken gizzard lining, and 10-20 parts of raw semi-arid 10-30 parts of summer mulberry, 10-30 parts of white silkworm, 10-30 parts of vinegar bupleurum, 10-30 parts of scutellaria, 10-30 parts of vinegar cyperus, 10-30 parts of costusroot, 5-20 parts of amomum, 30-80 parts of raw rehmannia, 20-80 parts of wine cornus, 20-50 parts of peony bark, 5-20 parts of leech, 15-30 parts of chuanxiong, 10-30 parts of salt phellodendron, 10-30 parts of cinnamon, and 10 parts of cooked pu'er tea.

[0007] Preferably, the astragalus, codonopsis, polygonatum, coptis, kudzu root, and radix trichosanthis are used as monarch drugs, and the monarch drugs are used to replenish the qi of the five internal organs, replenish the kidney and essence, strengthen the spleen and consolidate the foundation, promote the production of body fluids and quench thirst, and replenish qi and blood, so as to activate pancreatic islet cells and restore the normal function of the pancreas; the atractylodes, yam, Euryale ferox, dried ginger, chicken gizzard lining, raw pinellia, bombyx batryticatus, vinegar bupleurum, scutellaria, vinegar cyperus, costus root, and amomum are used as ministerial drugs, and the ministerial drugs are used to warm the kidney and consolidate essence, raise the clear and lower the turbid, dry dampness and strengthen the spleen, soothe the liver and regulate qi, enhance the transportation and transformation capacity of the stomach and intestines, replenish the acquired constitution, and strengthen the innate constitution, so as to restore the gastrointestinal system Normal transportation and transformation function, unblocking the whole body's Qi and promoting sugar metabolism; the raw rehmannia, cornus officinalis, moutan bark, leech, chuanxiong, phellodendron, cinnamon, and cooked Pu'er tea are used as adjuvants, and the raw rehmannia, cornus officinalis, moutan bark, leech, chuanxiong, phellodendron, cinnamon in the adjuvants are used to produce blood, activate blood circulation, cool blood, harmonize blood, dredge meridians, eliminate false fire, guide fire back to the origin, replenish liver blood, replenish heart Qi, strengthen spleen Qi, and strengthen kidney Qi to promote blood microcirculation, let blood sugar directly supply cells, and the cooked Pu'er tea in the adjuvant is used to nourish the stomach and protect the liver, lower blood lipids, lower blood sugar, and enhance the transportation and transformation capacity of the stomach and intestines.

[0008] Preferably, the monarch drug is reused to control the whole prescription and improve the hypoglycemic effect.

[0009] Beneficial effects: In the pharmaceutical composition for treating diabetes of the present invention, kudzu root, astragalus, coptis root, scutellaria, bupleurum, vinegar cyperus, and costus root are used to regulate the triple energizer, so as to achieve the purpose of raising the clear and lowering the turbid, regulating the water channel, and regulating the whole body's qi, thereby solving the problem of the overall metabolic circulation of the human body; astragalus, polygonatum, codonopsis, yam, atractylodes, chicken's gizzard, raw pinellia, bombyx batryticatus, coptis root, dried ginger, costus root, amomum, vinegar bupleurum, vinegar cyperus, cinnamon, and cooked pu'er tea are used to regulate the gastrointestinal system, so as to achieve the purpose of replenishing qi and generating blood, raising the clear and lowering erosion, and replenishing the gastrointestinal system. The purpose of kidney essence production, spleen and qi regulation, regulating the whole body qi, and enhancing the gastrointestinal transport function, thereby solving sugar metabolism problems and emotional diseases caused by liver depression and qi stagnation; using Codonopsis, Polygonatum, Rehmannia, Cornus, Cortex Moutan, Ligusticum chuanxiong, Leech, Phellodendron, and Cinnamon to regulate the blood circulation system, achieve the purpose of blood production, blood circulation, cooling blood, blood, blood circulation, and blood purification, so as to solve the problem of blood microcirculation, so that blood sugar can be directly supplied to cells, lower blood sugar, and prevent complications, thereby achieving the effect of spleen and kidney tonification, yin and yang coordination, and achieving the effect of treating the symptoms and the root cause at the same time. Generally, taking 14 doses of the above-mentioned drug composition for the treatment of diabetes mellitus for mild cases can eliminate the three symptoms, and the three symptoms can disappear after three months of treatment for a history of type 2 diabetes within ten years. BRIEF DESCRIPTION OF THE DRAWINGS

[0010] Figure 1 This is the blood sugar test report of patient 1 before and after taking the pharmaceutical composition of the present invention.

[0011] Figure 2 This is the blood sugar test report of patient 2 before and after taking the pharmaceutical composition of the present invention.

[0012] Figure 3 This is the blood sugar test report of patient 3 before and after taking the pharmaceutical composition of the present invention.

[0013] Figure 4 This is the blood sugar test report of patient 4 before and after taking the pharmaceutical composition of the present invention.

[0014] Figure 5 This is the blood sugar test report of patient 5 before and after taking the pharmaceutical composition of the present invention. DETAILED DESCRIPTION

[0015] In order to more clearly illustrate the technical solution of the present invention, the pharmaceutical composition for treating diabetes of the present invention will be further described in detail below in conjunction with examples.

[0016] A pharmaceutical composition for treating diabetes, prepared from the following Chinese medicinal raw materials in parts by weight: 30-120 parts of astragalus, 30-50 parts of codonopsis, 30-50 parts of polygonatum, 60-120 parts of trichosanthes, 30-50 parts of pueraria, 30-50 parts of coptis, 10-30 parts of atractylodes, 30-80 parts of raw yam, 10-30 parts of euryale, 5-20 parts of dried ginger, 30-60 parts of chicken gizzard lining, and 10-20 parts of raw semi-arid 10-30 parts of summer mulberry, 10-30 parts of white silkworm, 10-30 parts of vinegar bupleurum, 10-30 parts of scutellaria, 10-30 parts of vinegar cyperus, 10-30 parts of costusroot, 5-20 parts of amomum, 30-80 parts of raw rehmannia, 20-80 parts of wine cornus, 20-50 parts of peony bark, 5-20 parts of leech, 15-30 parts of chuanxiong, 10-30 parts of salt phellodendron, 10-30 parts of cinnamon, and 10 parts of cooked pu'er tea.

[0017] Among them, the astragalus, codonopsis, polygonatum, coptis, kudzu root, and trichosanthes are used as monarch drugs, and the monarch drugs are used to replenish the qi of the five internal organs, replenish the kidney and essence, strengthen the spleen and consolidate the foundation, promote fluid production and quench thirst, and replenish qi and blood, so as to activate pancreatic islet cells and restore the normal function of the islets; the atractylodes, yam, Euryale ferox, dried ginger, chicken gizzard lining, raw pinellia, bombyx batryticatus, vinegar bupleurum, scutellaria, vinegar cyperus, costus root, and amomum are used as ministerial drugs, and the ministerial drugs are used to warm the kidney and consolidate essence, ascend the clear and descend the turbid, dry dampness and strengthen the spleen, soothe the liver and regulate qi, enhance the transportation and transformation capacity of the stomach and intestines, replenish the acquired constitution, and strengthen the innate constitution, so that the gastrointestinal system can be restored to normal. The formula has the normal function of transportation and transformation, dredges the whole body's qi and promotes sugar metabolism; the raw rehmannia, cornus officinalis, moutan bark, leech, chuanxiong, phellodendron, cinnamon, and cooked Pu'er tea are used as assistants, and the raw rehmannia, cornus officinalis, moutan bark, leech, chuanxiong, phellodendron, cinnamon in the assistants are used to produce blood, activate blood circulation, cool blood, harmonize blood, dredge meridians, remove false fire, guide fire back to the origin, replenish liver blood, replenish heart qi, strengthen spleen qi, and strengthen kidney qi, so as to promote blood microcirculation, and allow blood sugar to be directly supplied to cells. The cooked Pu'er tea in the assistants is used to nourish the stomach and protect the liver, reduce fat and blood sugar, and enhance the transportation and transformation ability of the stomach and intestines. Among them, the monarch drug is reused to lead the whole prescription and improve the blood sugar-lowering effect.

[0018] The following is an introduction to the efficacy of the single herb of the pharmaceutical composition for treating diabetes:

[0019] Astragalus: sweet, slightly warm. Enters the spleen and lung meridians. Suitable for qi and blood deficiency, spontaneous sweating, fatigue and loss of appetite, loose stools, chronic cough and shortness of breath, and difficult ulcers. Pharmacological effects: diuretic, anti-fatigue, promote body metabolism, anti-bacterial, two-way regulation of blood sugar, anti-arrhythmia, lowering blood pressure, lowering blood lipids, anti-radiation, anti-anemia, liver protection, anti-aging, etc.

[0020] Codonopsis: sweet, neutral. It is good for the lungs and spleen. It is suitable for spleen and lung qi deficiency, lack of appetite and fatigue, cough and asthma, qi and blood deficiency, sallow complexion, palpitations and shortness of breath, thirst due to loss of body fluid, internal heat and thirst. Laziness and shortness of breath, weakness in the limbs, poor appetite, qi deficiency, qi and body fluid deficiency, qi and blood deficiency, and blood deficiency and sallow complexion. Pharmacological effects: cardiotonic, anti-shock, anti-fatigue, promote hematopoietic function, lower blood sugar, anti-inflammatory, anti-allergic, anti-tumor, promote hematopoietic system function, etc.

[0021] Polygonatum: sweet, neutral in nature. Enters the spleen, lung, and kidney meridians. Suitable for dry cough with little sputum, chronic cough, soreness of waist and knees, premature graying of hair and beard, fatigue, and loss of appetite. Pharmacological effects: antibacterial, improves the body's immunity, increases coronary flow, lowers blood pressure, lowers blood sugar, and anti-aging.

[0022] Pueraria root: sweet and spicy, cool in nature, enters the lung and stomach meridians. It relieves muscle and fever, clears rashes, promotes the production of body fluids and quenches thirst, and raises yang and stops diarrhea. Indications: It is used for fever due to superficial symptoms, stiff neck and back pain, measles that does not clear up, thirst due to febrile diseases, thirst due to yin deficiency, hot diarrhea and dysentery, and diarrhea due to spleen deficiency.

[0023] Coptis chinensis: Nature and flavor: bitter, cold. It enters the heart, spleen, stomach, gallbladder, and large intestine meridians. It is suitable for treating damp-heat dysentery, fullness, vomiting, high fever, irritability, insomnia, red eyes, toothache, thirst, eczema, carbuncle, furuncle. Pharmacological effects: antibacterial, antiarrhythmic, reduces myocardial oxygen consumption, anti-acute inflammation, choleretic, anti-diarrhea, inhibits gastric juice secretion, anti-cancer, and anti-ulcer.

[0024] Radix Trichosanthis: Nature and flavor: sweet, slightly bitter, slightly cold Meridians: Lung and stomach meridians. Efficacy: clearing away heat and purging fire, promoting the production of body fluids and quenching thirst, moistening the lungs and resolving phlegm, reducing swelling and draining pus. Efficacy and indications: clearing away heat and purging fire, promoting the production of body fluids and quenching thirst. Used for heat diseases that damage body fluids, stomach heat and thirst, and diabetes. Moistening the lungs and resolving phlegm. Pharmacological effects: Radix Trichosanthis has the effects of increasing immunity, anti-cancer, anti-virus, and bidirectional regulation of blood sugar.

[0025] Atractylodes: Nature, flavor, function and indications: pungent, bitter, warm. It can dry dampness and strengthen the spleen, dispel wind, dispel cold, and improve eyesight. It is used for abdominal distension, diarrhea, edema, beriberi, rheumatism, cold, night blindness. Pharmacological effects: It promotes gastrointestinal motility, resists ulcers, inhibits gastric acid secretion, lowers blood sugar, improves myocardial ischemia, has antibacterial, liver protection, central nervous system inhibition, and anti-tumor effects.

[0026] Chinese Yam: It is sweet and mild in nature, and it belongs to the spleen, lung, and kidney meridians. Its main functions are to nourish qi and yin, to tonify spleen, lung, and kidney qi, and to stop leukorrhea. It is mainly used clinically to tonify spleen qi, lung qi, and kidney qi, stop diarrhea, and stop leukorrhea. Pharmacological effects: Chinese Yam can enhance the absorption capacity of the small intestine, protect the gastric mucosa, lower blood sugar, resist oxidation, and resist aging. It has the effects of anesthesia, analgesia, anti-inflammatory, and antibacterial. It can also lower blood lipids and fight tumors.

[0027] Gorgon Fruit: Sweet, astringent, flat. Enters the spleen and kidney meridians. Efficacy: nourishes the kidney and consolidates the essence, strengthens the spleen and stops diarrhea, removes dampness and stops leukorrhea. Indications: 1. Spermatorrhea, spermatorrhea. 2. Spleen deficiency and chronic diarrhea. This product can both strengthen the spleen and remove dampness, and can also astringe and stop diarrhea. It can be used to treat spleen deficiency and dampness, chronic diarrhea, 3. Leukorrhea; Pharmacological effects: It has antioxidant, hypoglycemic, analgesic, and kidney protection effects. Anti-thrombotic effects.

[0028] Dried ginger: spicy, hot in nature, belongs to the spleen meridian, stomach meridian, kidney meridian, heart meridian, and lung meridian. It has the effects of warming the middle and dispersing cold, restoring yang and unblocking meridians, and warming the lungs and transforming fluid. It is often used to treat cold pain in the abdomen, vomiting and diarrhea, cold limbs and weak pulse, cold fluid and cough, and is the main medicine for warming the middle jiao. Pharmacological action: It has a slight stimulating effect on the digestive tract, can enhance intestinal tension, rhythm and peristalsis, thereby promoting gastrointestinal digestion. Enhance saliva secretion and enhance the digestion of starch. Dried ginger can dilate blood vessels, promote blood circulation, and has a cardiotonic effect. In addition, dried ginger also has antibacterial, anti-inflammatory, and immune-boosting effects.

[0029] Chicken gizzard lining: Nature and flavor and meridians: sweet, neutral. Enters the spleen, stomach, small intestine, and bladder meridians. Efficacy: invigorates the stomach and helps digestion, astringes sperm and stops nocturnal emission, relieves stranguria and dissolves stones. Indications: 1. Indigestion, vomiting, diarrhea, and malnutrition in children 2. Nocturnal emission and nocturnal emission 3. Painful stranguria and gallbladder distension and flank pain. Pharmacological effects: digestive enzyme action, promotes secretion of digestive juice, regulates gastrointestinal motility, lowers blood lipids, anti-coagulation, improves blood rheology, promotes excretion, lowers blood sugar, and resists breast hyperplasia. It is an important medicine for treating spleen and stomach transportation.

[0030] Raw Pinellia: pungent, warm. Toxic. Enters the spleen, stomach, and lung meridians. Efficacy: drying dampness and resolving phlegm, relieving adverse reactions and vomiting, eliminating lumps and dispersing masses; external use for relieving swelling and pain. Pharmacological effects: antitussive, antiemetic, gastrointestinal function regulation, choleretic, anti-cancer, and anti-early pregnancy.

[0031] Bombyx batryticatus: salty, pungent, neutral; enters the liver, lung, and stomach meridians. Efficacy: extinguishes wind and stops spasms, dispels wind and stops pain, dispels wind and stops itching, resolves phlegm and disperses nodules. Indications: used for convulsions, facial paralysis, headache, red eyes, sore throat, itching with rashes, scrofula and phlegm nodules. Pharmacological effects: hypoglycemic, hypnotic, anticonvulsant, anticoagulant, antibacterial, and anticancer effects.

[0032] Vinegar Bupleurum: Nature and flavor: bitter, slightly cold. Meridians: liver and gallbladder meridians. Efficacy: reconciling the exterior and interior, soothing the liver, and raising yang. Used for colds and fever, alternating colds and heat, chest and flank pain, irregular menstruation, uterine prolapse, and rectal prolapse. Pharmacological effects: antipyretic, anti-inflammatory, and immune-boosting.

[0033] Scutellaria baicalensis: Nature and flavor: cold and bitter, enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. Efficacy: drying dampness, purging fire, clearing heat, detoxifying, hemostasis, and stabilizing pregnancy. Effects: Suitable for summer heat, damp-heat fullness, chest tightness, nausea, diarrhea, jaundice, high fever and thirst, lung heat cough, carbuncle, sore, and restless fetus. Pharmacological effects: anti-pathogen, anti-inflammatory, immune function regulation, antipyretic, sedative, liver protection, and choleretic.

[0034] Vinegar-scented Cyperus: pungent, slightly bitter and sweet, neutral in nature. Enters the lung meridian, liver meridian, spleen meridian, stomach meridian, triple burner meridian. Efficacy: regulates qi and relieves depression, regulates menstruation and relieves pain. Indications: liver depression and qi stagnation, chest, flank, abdominal distension and pain, indigestion, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain caused by cold hernia, breast distension and pain. Pharmacological effects: regulates menstruation and relieves pain, antibacterial, antipyretic, cooling, anti-inflammatory, protects the bronchus, stops vomiting, calms the mind, lowers blood pressure, strengthens the heart and slows down the heart rate.

[0035] Costusroot: bitter in nature and flavor, enters the spleen, large intestine, and triple burner meridians. It has the effects of promoting qi, strengthening the spleen, digesting food, and relieving pain. It is mainly used to treat chest and abdominal distension and pain, heaviness after diarrhea, sudden deafness, snake and insect bites, nausea and vomiting, etc. Pharmacological effects: It has the effects of protecting gastric mucosa, anti-inflammatory, analgesic, regulating gastrointestinal motility, promoting bile secretion, inhibiting pathogenic microorganisms, and anti-tumor.

[0036] Amomum villosum: pungent and warm in nature, it enters the spleen, stomach and kidney meridians. Efficacy: remove dampness and stimulate appetite, warm the spleen and stop diarrhea, regulate qi and stabilize pregnancy. Indications: dampness blocking the middle jiao syndrome, spleen and stomach qi stagnation syndrome, spleen and stomach deficiency and cold, vomiting and diarrhea, nausea during pregnancy, and restless fetus. Pharmacological effects: enhance gastrointestinal motility, promote gastric juice secretion, lower blood sugar, as well as anti-ulcer, anti-diarrhea, choleretic, anti-inflammatory, antibacterial, and analgesic effects.

[0037] Raw Rehmannia root: sweet, bitter, cold. Enters the heart, liver, and kidney meridians. Functions: cools blood and clears heat, nourishes yin and tonifies the kidney, promotes the production of body fluids and quenches thirst. It is often used to treat heat entering the blood, bone steaming, tuberculosis, dry throat pain, blood in sputum, etc. Pharmacological effects: anti-radiation, liver protection, lowering blood sugar, cardiotonic, hemostatic, diuretic, anti-fungal, etc., and can be used for a variety of diseases.

[0038] Cornus officinalis: sour and astringent, slightly warm in nature, belongs to the liver and kidney meridians, effects: nourishing the liver and kidneys, astringent and firm, astringent and stopping nocturnal emission. Indications: liver and kidney deficiency, soreness of waist and knees, nocturnal emission, nocturnal enuresis, metrorrhagia, thirst, sweating and collapse. Pharmacological effects: Cornus officinalis has the effects of lowering blood sugar, lowering blood lipids, enhancing immune function, anti-arrhythmia, anti-aging, antioxidant, anti-inflammatory, antispasmodic, and antibacterial.

[0039] Peony bark: pungent, bitter, and cool. Meridians: mainly enter the heart, liver, and kidney meridians. Efficacy: clearing heat, cooling blood, harmonizing blood, and removing blood stasis. Indications: heat entering the blood, rash, epilepsy, cough, epistaxis, bloody stool, bone steaming and fatigue fever, yin deficiency and night sweats, amenorrhea, masses, carbuncles, and injuries from falls. In modern clinical practice, it is mainly used to treat hypertension or allergic rhinitis. Pharmacological effects: clearing heat, promoting blood circulation, dispersing blood stasis, cooling blood, sedation, hypnosis, lowering blood pressure, antibacterial, and promoting menstruation and relieving pain.

[0040] Leeches: They are salty in nature and slightly toxic. They are for the liver meridian and mainly have the effects of promoting blood circulation, breaking up blood, and unblocking meridians. They can be used clinically to treat hypertension, stroke, amenorrhea, and traumatic injuries. Pharmacological effects: They have a good effect on anti-cancer, prevention and treatment of cardiovascular and cerebrovascular diseases, and can also play an anti-thrombotic role.

[0041] Ligusticum chuanxiong: Nature and flavor: spicy, warm; it enters the liver, gallbladder, and pericardium meridians. Suitable for: 1. It can promote blood circulation and qi circulation, and treat irregular menstruation, amenorrhea, dysmenorrhea, postpartum abdominal pain, chest pain, lumps, rib pain, traumatic injuries, blood stasis and swelling, limb numbness, and sores; 2. It can dispel wind and relieve pain, and treat headaches and rheumatic pain. Pharmacological effects: (1) It can prevent vitamin E deficiency. (2) Ligustrazine can dilate coronary arteries, increase coronary blood flow, improve myocardial blood oxygen supply, and reduce myocardial oxygen consumption. (3) Ligustrazine can reduce platelet surface activity, inhibit platelet aggregation, and prevent thrombosis. (4) Ligustrazine can dilate cerebral blood vessels, reduce vascular resistance, significantly increase brain and limb blood flow, and improve microcirculation. (5) Ligustrazine can accelerate the absorption of local hematomas in fractures and promote bone callus formation. (6) The neutral component of ferulic acid contained in Chuanxiong promotes uterine smooth muscle in small doses and inhibits it in large doses. (7) The decoction of Chuanxiong has a sedative effect on the central nervous system of animals and has a significant and lasting hypotensive effect. (8) Chuanxiong can inhibit a variety of bacteria. (9) Chuanxiong has antihistamine and choleretic effects.

[0042] Phellodendron chinense: bitter and cold in nature. Efficacy: clears away heat and dries dampness, purges fire and removes steam, detoxifies and treats sores. Used for damp-heat diarrhea, jaundice, leucorrhea, hot stranguria, beriberi, paralysis, bone steaming and fatigue fever, night sweats, spermatorrhea, sores, swelling and poison, eczema and itching. Salted Phellodendron chinense nourishes yin and reduces fire. Pharmacological effects: It has anti-pathogenic microorganism, anti-inflammatory, immunosuppressive effects, and also has antihypertensive, antioxidant, anti-gout effects, etc.

[0043] Cinnamon: pungent, sweet, and hot in nature, it belongs to the kidney, spleen, heart, and liver meridians. Efficacy: replenishes fire and yang, dispels cold and relieves pain, warms the meridians and dredges the vessels, and guides fire back to the origin. It can be used clinically to treat a variety of diseases caused by kidney yang deficiency. It can also be used to treat a variety of diseases caused by cold coagulation and blood stasis. Pharmacological effects: dilate blood vessels, promote blood circulation, increase coronary and cerebral blood flow, resist myocardial ischemia, inhibit platelet aggregation, protect gastric mucosa, resist ulcers, calm, and relieve pain.

[0044] Ripe Pu'er Tea: Mild in nature, brown-red in color. Efficacy: nourishing the stomach, protecting the stomach, warming the stomach, harmonizing blood, lowering blood lipids, lowering blood sugar, lowering blood pressure, and anti-atherosclerosis. Pharmacological effects: 1. Lipid reduction, weight loss; 2. Anti-cancer, anti-cancer; 3. Nourishing the stomach, protecting the stomach; 4. Strengthening teeth and protecting teeth; 5. Anti-inflammatory, sterilizing, curing dysentery; 6. Anti-aging; 7. Therapeutic effects on cardiovascular and cerebrovascular diseases, hypertension, coronary heart disease, high fat, diabetes, depression, leukoencephalopathy, Parkinson's disease, menopausal syndrome, osteoporosis and intracranial tumor surgery.

[0045] Prescription and dosage are the key to cure diseases in traditional Chinese medicine. At the same time, the present application also reuses the main medicine, breaks through the conventional dosage limit, and uses the main medicine of weight to achieve the therapeutic effect of rapid symptom reduction, rapid blood sugar reduction, and short course of treatment. The pharmaceutical composition for treating diabetes of the present invention can be in the form of decoction, powder, tea and other conventional pharmaceutical preparations according to actual conditions. The present invention is further described in the form of decoction combined with powder in conjunction with the embodiments below to verify the implementation effect of the present invention.

[0046] Example 1, please also refer to Figure 1 :

[0047] Name: Zhang XX Date of Birth: October 7, 1970 Gender: Female Age: 45

[0048] Phone: XXXXXX Consultation time: May 2, 2019

[0049] Address: 3-401, Building XXX, XXXX Community, Jinfeng District, Yinchuan City, Ningxia

[0050] Work unit: Ningxia XXXX Company employee

[0051] Past medical history: Qi deficiency, cold limbs, and sweating.

[0052] Medical consultation: Main complaint: Recently I have been thirsty, especially fond of drinking water, and sweating a lot. Examination revealed that my blood sugar level was high, with a fasting blood sugar level of 6.7. I have loose stools, yellow urine, and clear and thin vaginal discharge with a large amount. I have a poor appetite and lack of sleep.

[0053] Observation: yellow complexion, dark circles under the eyes, chapped lips, red tongue with a thin white coating.

[0054] Auscultation: The patient has a deep voice, is weak and sweats a lot.

[0055] Palpation: The pulse is thready and weak.

[0056] Syndrome differentiation: deficiency of both Qi and Yin.

[0057] Treatment method: Replenish Qi and nourish Yin, and regulate Yin and Yang.

[0058] Prescription: 50 parts of Astragalus, 30 parts of Codonopsis, 30 parts of Polygonatum, 60 parts of Radix Trichosanthis, 30 parts of Pueraria, 20 parts of Coptis, 10 parts of Atractylodes, 30 parts of raw Chinese yam, 10 parts of Euryale, 5 parts of dried ginger, 30 parts of chicken gizzard lining, 10 parts of raw Pinellia, 10 parts of Bombyx batryticatus, 10 parts of vinegar Bupleurum, 10 parts of Scutellaria, 10 parts of vinegar Cyperus, 10 parts of costus root, 5 parts of Amomum, 30 parts of raw Rehmannia, 30 parts of wine Cornus, 20 parts of Cortex Moutan, 5 parts of Leech, 15 parts of Ligusticum chuanxiong, 10 parts of salt Phellodendron, 10 parts of cinnamon, and 10 parts of cooked Pu'er tea.

[0059] Doctor's advice: 14 doses of decoction, one dose per day, 250 ml warm half an hour after breakfast and dinner. Avoid smoking, drinking, spicy food.

[0060] Second visit: The above symptoms have been alleviated, but the patient still suffers from fatigue and excessive sweating. The original prescription remains unchanged and another 14 doses are taken.

[0061] Third visit: Symptoms disappeared, blood sugar was stable (fasting blood sugar 5.6). Three doses of powder were taken for one month for consolidation treatment, twice a day, 10 grams each time with warm water.

[0062] Example 2, please also refer to Figure 2 :

[0063] Name: Li XXX Date of Birth: November 3, 1975 Gender: Female Age: 45

[0064] Phone: XXXXXX Consultation time: June 3, 2020

[0065] Address: 4-501, Building XX, XX Community, Yinchuan City, Ningxia

[0066] Work unit: XX Property Company employee

[0067] Past medical history: Qi and blood deficiency, ecchymosis on legs.

[0068] Inquiry: Chief complaint: I have been a little thirsty recently, with dry mouth and frequent urination. Examination revealed that my blood sugar is high, with a fasting blood sugar of 6.5. My stool is not formed.

[0069] Yellow vaginal discharge. Upset. Can eat. Stomach ache. Distension.

[0070] 2. Inspection: thin body, listless, walks very fast, red tongue with yellow and greasy coating, and petechiae on sublingual veins.

[0071] 3. Auscultation: The voice is low, weak and with breath.

[0072] 4. Palpation: The left pulse is rapid, astringent and weak.

[0073] Diagnosis: diabetes due to deficiency of both Qi and Yin.

[0074] Treatment method: Invigorate Qi and nourish Yin, promote blood circulation and remove blood stasis.

[0075] Prescription: 30 parts of Astragalus, 30 parts of Codonopsis, 30 parts of Nine-fried Polygonatum, 60 parts of Radix Trichosanthis, 30 parts of Puerariae Radix, 20 parts of Coptis chinensis, 10 parts of Atractylodes, 30 parts of Raw Chinese Yam, 10 parts of Euryale, 5 parts of Dried Ginger, 30 parts of Chicken's Gizzard, 10 parts of Raw Pinellia, 10 parts of Bombyx Batryticatus, 10 parts of Vinegar Bupleurum, 10 parts of Scutellaria, 10 parts of Vinegar Cyperus, 10 parts of Aucklandia, 5 parts of Amomum, 30 parts of Raw Rehmannia, 20 parts of Wine Cornus, 20 parts of Cortex Moutan, 10 parts of Leech, 20 parts of Ligusticum chuanxiong, 20 parts of Salted Phellodendron, 10 parts of Cinnamon, 10 parts of Ripe Pu'er Tea

[0076] Doctor's advice: 14 doses of decoction, one dose per day, 250 ml warm half an hour after breakfast and dinner. Avoid smoking, drinking, spicy food.

[0077] Follow-up visit: The above symptoms were alleviated, and the original prescription remained unchanged. Another 14 doses were taken.

[0078] Third visit: The hospital checked the fasting blood sugar and it was 5.5. Three doses of the original prescription were taken with powder, 10g each morning and evening with warm water to consolidate the treatment.

[0079] Example 3, please also refer to Figure 3 :

[0080] Name: Sun XX Date of Birth: October 1970 Gender: Female Age: 50

[0081] Phone: XXXXXX Consultation time: June 6, 2020

[0082] Address: XX District, Yinchuan City, Ningxia

[0083] Occupation: Company CEO.

[0084] Past medical history: spleen and kidney deficiency,

[0085] Medical consultation: Main complaint: small appetite, bloating after eating, frequent urination, foamy urine, strong odor, fasting blood sugar 6.8. Leucorrhea has odor and is yellow in color.

[0086] Observation: dull eyes, fatigue, pale face, red tongue, yellow and greasy tongue coating, and ecchymosis on the tongue surface.

[0087] Auscultation: The patient speaks in a low voice and with a heavy breath.

[0088] Palpation: left pulse is rapid and wiry.

[0089] Syndrome differentiation: spleen and kidney deficiency, dampness and turbidity stagnate in the body, and the stagnation turns into heat. Diagnosis: spleen and kidney deficiency and thirst.

[0090] Treatment method: Warm and nourish spleen yang, strengthen spleen and remove dampness, raise clearness and lower turbidity, clear heat and detoxify.

[0091] Prescription: 50 parts of Astragalus, 30 parts of Codonopsis, 30 parts of Nine-fried Polygonatum, 60 parts of Radix Trichosanthis, 30 parts of Puerariae Radix, 30 parts of Coptis chinensis, 10 parts of Atractylodes, 30 parts of Raw Chinese Yam, 10 parts of Euryale, 5 parts of Dried Ginger, 30 parts of Chicken's Gizzard, 10 parts of Raw Pinellia, 20 parts of Bombyx Batryticatus, 15 parts of Vinegar Bupleurum, 15 parts of Scutellaria, 15 parts of Vinegar Cyperus, 10 parts of Aucklandia, 5 parts of Amomum, 30 parts of Raw Rehmannia, 20 parts of Wine Cornus, 20 parts of Cortex Moutan, 10 parts of Leech, 20 parts of Ligusticum chuanxiong, 20 parts of Salted Phellodendron, 10 parts of Cinnamon, and Ripe Pu'er Tea

[0092] Doctor's advice: 14 doses of decoction, one dose per day, 250 ml warm half an hour after breakfast and dinner. Avoid smoking, drinking, spicy food.

[0093] Follow-up visit: Symptoms alleviated, fasting blood sugar 7.0. The original prescription remained unchanged, and 14 more doses were taken.

[0094] Third visit: Symptoms basically disappeared. Fasting blood sugar 6.1. The original prescription remained unchanged and 14 doses were taken.

[0095] Four examinations: Symptoms disappeared. Blood sugar is stable, fasting blood sugar is 6.0. The original prescription remains unchanged, and three more doses of powder are taken to consolidate the treatment for one month, morning and evening every day

[0096] Take once, 10 grams each time with warm water.

[0097] Example 4, please also refer to Figure 4 :

[0098] Name: Yang XX Date of Birth: June 20, 1969 Gender: Male Age: 48

[0099] Phone: XXXXXX Consultation time: October 15, 2019

[0100] Address: XX, Yinchuan, Ningxia Workplace: Company CEO,

[0101] Medical history: Family hereditary diabetes. Main complaint: thirst, frequent urination, strong stomach fire, constipation, unstable blood sugar, sometimes fasting blood sugar can reach 7.8 to 16. My father died of diabetes. He was 62 years old. I have diabetes for ten years. My blood sugar is unstable, sometimes hypoglycemia, sometimes post-meal blood sugar can reach 17 or 18, severe constipation, bowel movement every three or two days, yellow urine with foam.

[0102] Observation: The patient is obviously thin, the tongue is red with cracks, the sublingual veins are distended, the tongue coating is yellow and greasy, there are dark circles under the eyes, and the tongue is fat.

[0103] Auscultation: The voice is low and weak. The body smells like rotten apples.

[0104] Palpation: The left pulse is deep, sluggish and weak.

[0105] Dialectics: Deficiency of Yin and Yang

[0106] Diagnosis: Diabetes mellitus due to deficiency of both yin and yang.

[0107] Treatment method: replenish qi and nourish yin, activate blood circulation and dredge collaterals, raise the clear and lower the turbid, and regulate both yin and yang

[0108] Prescription: 30 parts of Astragalus, 30 parts of Codonopsis, 30 parts of Nine-fried Polygonatum, 80 parts of Radix Trichosanthis, 30 parts of Puerariae Radix, 40 parts of Coptis chinensis, 10 parts of Atractylodes, 30 parts of Raw Chinese Yam, 10 parts of Euryale ferox, 5 parts of Dried Ginger, 30 parts of Chicken's Gizzard Stone, 10 parts of Raw Pinellia, 20 parts of Bombyx Batryticatus, 20 parts of Vinegar Bupleurum, 20 parts of Scutellaria, 10 parts of Vinegar Cyperus, 10 parts of Costusroot, 5 parts of Amomum, 30 parts of Raw Rehmannia, 30 parts of Wine Cornus, 30 parts of Paeonia suffruticosa, 5 parts of Leech, 20 parts of Ligusticum chuanxiong, 20 parts of Salted Phellodendron, 10 parts of Cinnamon, and Ripe Pu'er Tea.

[0109] Doctor's advice: 14 doses of decoction, one dose per day, 250 ml warm half an hour after breakfast and dinner. Avoid smoking, drinking, spicy food.

[0110] Follow-up visit: Blood sugar no longer fluctuates, fasting blood sugar is around 7.8, the original prescription remains unchanged, and another 14 doses are taken.

[0111] Third visit: Blood sugar is stable, fasting blood sugar is 6.5, and the above symptoms have improved. The original prescription is unchanged and another 14 doses are taken.

[0112] Fourth diagnosis: The above symptoms have been basically eliminated, the patient is in high spirits, and the fasting blood sugar is around 6.2. The original prescription remains unchanged and 14 more doses are taken.

[0113] Fifth diagnosis: basic symptoms disappeared. Fasting blood sugar 5.3-6.0. Seven more prescriptions were given for long-term consolidation treatment for two months. Later, a telephone consultation: the basic symptoms of diabetes disappeared, the quality of life improved, and blood sugar was stable.

[0114] Example 5, please also refer to Figure 5 :

[0115] Name: Wang XX Date of Birth: November 13, 1984 Gender: Male Age: 36

[0116] Phone: XXXXXX Consultation time: May 28, 2022

[0117] Address: XX Community, Pingluo County, Ningxia Workplace: Supermarket owner,

[0118] Medical history: hyperlipidemia, main complaint: recent thirst and frequent urination, fasting blood sugar 6.3, dry stool, yellow urine, dampness and heaviness in legs.

[0119] Inspection: The patient is weak and listless, puffy, with a red tongue, a yellow and greasy coating, and water on the tongue surface.

[0120] Auscultation: Deep voice, heavy breath, strong body odor.

[0121] Qiezhen: The pulse is deep, slippery and weak. Diagnosis: Both Qi and Yin are damaged, and the spleen is not functioning properly.

[0122] Treatment: replenish qi and nourish yin, strengthen the spleen and promote water excretion

[0123] Prescription: 60 parts of Astragalus, 30 parts of Codonopsis, 30 parts of Nine-fried Polygonatum, 60 parts of Radix Trichosanthis, 30 parts of Puerariae Radix, 20 parts of Coptis chinensis, 20 parts of Atractylodes, 30 parts of Raw Chinese Yam, 10 parts of Euryale ferox, 5 parts of Dried Ginger, 30 parts of Chicken Gizzard Stone, 10 parts of Raw Pinellia, 10 parts of Bombyx Batryticatus, 10 parts of Vinegar Bupleurum, 10 parts of Scutellaria, 10 parts of Vinegar Cyperus, 10 parts of Costusroot, 5 parts of Amomum, 30 parts of Raw Rehmannia, 20 parts of Wine Cornus, 20 parts of Peony, 5 parts of Leech, 15 parts of Ligusticum chuanxiong, 20 parts of Salted Phellodendron, 10 parts of Cinnamon, and Ripe Pu'er Tea.

[0124] Doctor's advice: 14 doses of decoction, one dose per day, 250 ml warm half an hour after breakfast and dinner. Avoid smoking, drinking, spicy food.

[0125] Follow-up visit: The patient is in high spirits and has smooth bowel movements. The original prescription remains unchanged and another 14 doses are taken.

[0126] Third visit: fasting blood sugar 5.6. Basic symptoms were alleviated, and three more doses of powder were taken to consolidate the treatment for one month, 10 grams each morning and evening, with warm water.

[0127] What is disclosed above is only a preferred embodiment of the present invention, and it certainly cannot be used to limit the scope of rights of the present utility model. A person skilled in the art can understand that all or part of the processes of the above embodiments and equivalent changes made according to the claims of the present utility model still fall within the scope covered by the utility model.

Claims

1. A pharmaceutical composition for treating diabetes, characterized in that: The invention is prepared from the following Chinese medicinal raw materials in parts by weight: 30-120 parts of astragalus, 30-50 parts of codonopsis, 30-50 parts of polygonatum, 60-120 parts of radix trichosanthis, 30-50 parts of puerariae, 30-50 parts of coptis, 10-30 parts of atractylodes, 30-80 parts of raw yam, 10-30 parts of euryale, 5-20 parts of dried ginger, 30-60 parts of chicken gizzard lining, 10-30 parts of raw pinellia , 10-30 parts of white silkworm, 10-30 parts of vinegar bupleurum, 10-30 parts of scutellaria, 10-30 parts of vinegar cyperus, 10-30 parts of costusroot, 5-20 parts of amomum, 30-80 parts of raw rehmannia, 20-80 parts of wine cornus, 20-50 parts of peony bark, 5-20 parts of leech, 15-30 parts of chuanxiong, 10-30 parts of salt phellodendron, 10-30 parts of cinnamon, and 10 parts of cooked pu'er tea.

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