Microsystem for delivering a plurality of materials

Abstract

Disclosed is a microsystem for delivering a plurality of materials. The microsystem for delivering a plurality of materials can include a microstructure in which a microneedle is formed on one surface of a base film and the microstructure is made of a first material, and a material accommodation portion disposed in one region of the microstructure and having an accommodation space for accommodating a second material different from the first material.

Description

Technical Field

[0001] This invention relates to a multi-material delivery microsystem, and more specifically, to a microsystem capable of delivering multiple materials by permeating multiple materials into the skin. Background Technology

[0002] Routes of administration for delivering materials (including drugs or cosmetics) to the human body include oral, injectable, and transdermal administration. Oral administration is the most common and convenient method, delivering the active ingredient to the body in the form of capsules, tablets, or syrups. However, some active ingredients may be inactivated due to first-pass metabolism in the liver, etc. Therefore, to increase the effectiveness of the active ingredients, they are administered by piercing the skin (the body's defense barrier) through injection. Injection has the advantage of maintaining the activity of the delivered active ingredient, but has disadvantages such as the risk of infection, inaccurate dosage, needle phobia, and pain.

[0003] Therefore, various transdermal active ingredient delivery systems based on microstructures have been developed, including minimally invasive biodegradable microneedles, to overcome the limitations of existing oral and injectable drug delivery routes. Biodegradable microstructures are transdermal delivery systems in which various active ingredients (including polymers, cosmetics, drugs, etc.) are formulated in the form of microneedles, inserted into the skin, and then delivered painlessly through dissolution in bodily fluids.

[0004] However, biodegradable microstructures have limited active ingredient loading capacity (limited encapsulation capacity). Because typical biodegradable microstructures are manufactured at microscopic dimensions of tens to hundreds of micrometers, the loading capacity is limited. Therefore, the required amount of active ingredient cannot be delivered to the human body, and this limits the application of biodegradable microstructures primarily to the cosmetics industry.

[0005] Furthermore, biodegradable microstructures present adhesion difficulties (difficulty with continuous skin adhesion). Typically, biodegradable microstructures are applied to the skin as patches and require minutes to hours to dissolve. Therefore, there are limitations such as the risk of various skin conditions (including itching, dermatitis, and allergies) due to the adhesion and inconvenience of the patch. Additionally, regardless of the application time, there is a problem that the loaded active ingredients may not be effectively delivered because the microstructures are not fully inserted into the skin due to their sharp tips and wide bases.

[0006] Furthermore, when multiple active ingredients are mixed, biodegradable microstructures present the risk of inactivation (risk of activity loss in multi-compound mixtures). Specifically, when mixed with biomaterials, polymers, and other active ingredients, they may become inactivated due to various chemical reactions, depending on the nature of the active ingredients. Therefore, when multiple materials are loaded onto microstructures, there is a disadvantage that the activity and stability of the active ingredients may decrease.

[0007] Furthermore, biodegradable microstructures have limitations in loading hydrophobic active ingredients (and in encapsulating poorly soluble compounds). Biodegradable microstructures are typically fabricated using hydrophilic polymers. Therefore, active ingredients with hydrophobic molecules cannot be loaded onto these microstructures, or complex targeting processes are required to load them. Summary of the Invention

[0008] Technical issues

[0009] The present invention provides a multi-material delivery microsystem that maximizes the loading capacity and delivery volume of the compound to be delivered while maintaining the activity of the material.

[0010] Furthermore, the present invention provides a multi-material delivery microsystem that can rapidly deliver materials loaded on microneedles into the skin.

[0011] Technical solution

[0012] The multi-material delivery microsystem according to this disclosure may include: a microstructure in which microneedles are formed on a surface of a base film and the microstructure is made of a first material; and a material receiving portion located in a region of the microstructure and having a receiving space for receiving a second material different from the first material.

[0013] Furthermore, the base film may have a surface comprising: a central region; and a peripheral region surrounding the central region and in which the microneedles are formed, and the material receptacle may be located in the central region of the base film.

[0014] Furthermore, the receiving space can be positioned such that the center of the bottom surface of the receiving space is lower than one surface of the base film.

[0015] In addition, the material receiving portion may also include an annular partition wall surrounding the receiving space and positioned such that the upper end of the partition wall is lower than the tip of the microneedle.

[0016] Furthermore, the partition wall may be configured as a corrugated wall having an upper end that is located at a first height in an expanded state and at a second height below the first height in a contracted state.

[0017] Furthermore, the partition wall includes: a first partition wall layer in an annular shape; and a second partition wall layer located below the first partition wall layer, and having a space in the second partition wall layer capable of accommodating the first partition wall layer. The first partition wall layer and the second partition wall layer are switchable between a first state and a second state. In the first state, the first partition wall layer and the second partition wall layer are stacked in multiple levels. In the second state, the first partition wall layer is located inside the second partition wall layer.

[0018] In addition, the partition wall may include: support portions positioned sequentially and spaced apart from each other along the outer periphery of the receiving space; and connecting portions located between the support portions and having a thickness thinner than the thickness of the support portions.

[0019] Furthermore, the diameter and thickness of the partition wall may gradually decrease as the partition wall extends from its lower end to its upper end.

[0020] Furthermore, as the partition wall extends from its lower end to its upper end, the diameter of the partition wall can gradually increase and the thickness of the partition wall can gradually decrease.

[0021] In addition, the material receiving portion may also include a support plate located on the bottom of the base film and giving the material receiving portion a partition wall integrally formed in its central region.

[0022] Furthermore, the support plate may have an internal portion in which a storage space for storing the second material is formed, and an opening is formed connecting the storage space and the receiving space.

[0023] Furthermore, the support plate has a storage space connected to and formed therein with the receiving space, the bottom surface of the storage space being configured as a film of thin thickness, and the material receiving portion may also include a pushing portion that presses against the bottom surface of the storage space and is inserted into the storage space to push the second material stored in the storage space.

[0024] Furthermore, the support plate has a storage space connected to and formed therein, the bottom surface of the storage space being configured to bulge downwards and have a thin membrane, and when the bottom surface of the storage space is pressed from the outside, the bottom surface of the storage space can be pressed against the receiving space.

[0025] Furthermore, the multi-material delivery microsystem may also include: a diaphragm forming a plurality of storage spaces separated by partition walls in the material receiving portion, and the diaphragm being located in an opening of the base membrane; an outflow prevention membrane blocking the opening formed in the base membrane and located between the storage spaces and the diaphragm; and a punch rod having a plurality of ends respectively located in each of the storage spaces, and the punch rod being capable of impacting the outflow prevention membrane, wherein different materials are respectively stored in each of the storage spaces, and each material can be introduced into the diaphragm and mixed with each other through holes formed in the outflow prevention membrane by the impact of the punch rod.

[0026] Beneficial effects

[0027] According to the present invention, the material loaded on the microneedle and the material contained in the material reservoir can simultaneously penetrate into the skin.

[0028] Furthermore, according to the present invention, since the second material can quickly dissolve the first material, the first material can penetrate into the skin in a short time. Attached Figure Description

[0029] Figure 1 This is an exploded perspective view illustrating a multi-material delivery microsystem according to an embodiment of the present invention.

[0030] Figure 2 It is shown Figure 1 A cross-sectional view of the microstructure.

[0031] Figure 3 This is a photograph of a sample microstructure manufactured according to an embodiment of the present invention.

[0032] Figure 4 This is a sample photograph showing the state of the second material loaded on the material container of the microstructure.

[0033] Figure 5 and Figure 6 The diagram sequentially illustrates the process of delivering a first material and a second material into the skin using a multi-material delivery microsystem according to an embodiment of the present invention.

[0034] Figure 7 This is a cross-sectional view illustrating a multi-material delivery microsystem according to another embodiment of the present invention.

[0035] Figure 8 and Figure 9 This is a cross-sectional view illustrating a multi-material delivery microsystem according to another embodiment of the present invention.

[0036] Figure 10This is a perspective view illustrating a multi-material delivery microsystem according to another embodiment of the present invention.

[0037] Figure 11 It is shown Figure 10 An exploded three-dimensional view of a multi-material delivery microsystem.

[0038] Figure 12 It is shown Figure 10 Cross-sectional view of a multi-material delivery microsystem.

[0039] Figure 13 It shows the use according to Figure 12 An illustration of the process by which a multi-material delivery microsystem of an embodiment inserts microneedles into the skin.

[0040] Figure 14 This is a cross-sectional view showing a partition wall structure according to another embodiment of the present invention.

[0041] Figure 15 It is shown Figure 14 A diagram showing the appearance of the deformed partition wall structure.

[0042] Figure 16 This is a cross-sectional view showing a partition wall structure according to another embodiment of the present invention.

[0043] Figure 17 It is shown Figure 16 A diagram showing the appearance of the deformed partition wall structure.

[0044] Figure 18 This is a cross-sectional view showing a partition wall structure according to another embodiment of the present invention.

[0045] Figure 19 It is shown Figure 18 A diagram showing the appearance of the deformed partition wall structure.

[0046] Figure 20 This is a cross-sectional view showing a partition wall structure according to another embodiment of the present invention.

[0047] Figure 21 It is shown Figure 20 A diagram showing the appearance of the deformed partition wall structure.

[0048] Figure 22 This is a diagram displayed on the XY plane, illustrating a partition wall structure according to another embodiment of the present invention.

[0049] Figure 23 It is shown Figure 22 A diagram showing the appearance of the deformed partition wall structure.

[0050] Figure 24This is a cross-sectional view illustrating a multi-material delivery microsystem according to another embodiment of the present invention.

[0051] Figure 25 It is shown Figure 24 A diagram illustrating the usage status of a multi-material delivery microsystem.

[0052] Figure 26 This is a cross-sectional view illustrating a multi-material delivery microsystem according to another embodiment of the present invention.

[0053] Figure 27 This is a cross-sectional view illustrating a multi-material delivery microsystem according to another embodiment of the present invention.

[0054] Figure 28 This is a cross-sectional view illustrating a multi-material delivery microsystem according to another embodiment of the present invention.

[0055] Figure 29 It is shown Figure 28 A diagram illustrating the operation of a multi-material delivery microsystem.

[0056] Figures 30 to 32 This is a plan view showing the microstructure according to various embodiments.

[0057] Best way to carry out the invention

[0058] The multi-material delivery microsystem according to the present invention may include: a microstructure in which microneedles are formed on a surface of a base film and the microstructure is made of a first material; and a material receiving portion located in a region of the microstructure and having a receiving space for receiving a second material different from the first material. Detailed Implementation

[0059] Preferred embodiments of the invention will be described in detail below with reference to the accompanying drawings. However, the inventive concept is not limited to the embodiments described herein and may be embodied in other forms. Rather, the embodiments described herein are provided so that the disclosure will be thorough and complete, and the spirit of the invention will be fully conveyed to those skilled in the art.

[0060] In this specification, when an element is referred to as being on another element, it means that it can be formed directly on the other element, or that a third element can be inserted therebetween. Furthermore, in the accompanying drawings, the thickness of the membrane and the region is exaggerated for the purpose of effectively explaining the technical content.

[0061] Furthermore, although terms such as first, second, and third have been used to describe various elements in the various embodiments of this specification, these elements should not be limited by these terms. These terms have only been used to distinguish one element from another. Thus, an element referred to as a first element in one embodiment may be referred to as a second element in another embodiment. Each embodiment described and illustrated herein also includes supplementary embodiments thereof. Additionally, in this specification, "and / or" has been used to indicate the inclusion of at least one of the elements listed before and after.

[0062] In this specification, singular expressions include plural expressions unless the context clearly specifies otherwise. Furthermore, the terms "comprising" or "having" are intended to indicate the presence of the features, quantities, steps, components, or combinations thereof described in the specification, but should not be construed as excluding the possibility of the presence or addition of one or more other features, quantities, steps, components, or combinations thereof. Additionally, in this specification, "connected" is used to mean both indirectly connecting multiple components and directly connecting multiple components.

[0063] Furthermore, in the following description of the invention, a detailed description of a relevant known function or configuration will be omitted if it is determined that such a detailed description may unnecessarily obscure the subject matter of the invention.

[0064] Figure 1 This is an exploded perspective view illustrating a multi-material delivery microsystem according to an embodiment of the present invention, and Figure 2 It is shown Figure 1 A cross-sectional view of the microstructure.

[0065] Reference Figure 1 and Figure 2 The multi-material delivery microsystem 10 can deliver a first material and a second material to the user's skin.

[0066] The first material is a biodegradable material that dissolves after penetrating the skin and is non-toxic, chemically inert, and non-immunogenic to the human body. It can be broken down in the body by bodily fluids and microorganisms.

[0067] According to one embodiment, the first material may include hyaluronic acid, polyester, polyhydroxyalkanoates (PHAs), poly(α-hydroxy acids), poly(β-hydroxy acids), poly(3-hydroxybutyrate-co-hydroxyvalerate (PHBV), poly(3-hydroxypropionate) (PHP), poly(3-hydroxyhexanoate) (PHH), poly(4-hydroxy acids), poly(4-hydroxybutyrate), poly(4-hydroxyvalerate), poly(4-hydroxyhexanoate), poly(esteramide), polycaprolactone, polylactide, polyglycolic acid, poly(lactide-co-glycolic acid) (PLGA), polydioxanone, polyorthoester, polyether ester, polyanhydride, poly(glycolic acid-co-trimethylene carbonate), polyphosphate, polyphosphate urethane, poly(amino acid), polycyanoacrylate, poly(trimethylene carbonate), poly(imino carbonate), poly(tyrosine carbonate), polycarbonate, poly(tyrosine aryl compound), poly(alkylene oxalate), poly Phosphates, phytohemagglutinin-polyethylene glycol (PHA-PEG), ethylene-vinyl alcohol copolymer (EVOH), polyurethane, silicone, polyester, polyolefins, polyisobutylene and ethylene-α-olefin copolymers, styrene-isobutylene-styrene triblock copolymers, acrylic polymers and copolymers, ethylene halide polymers and copolymers, polyvinyl chloride, polyvinyl ether, polyvinyl methyl ether, polyvinylidene halide, polyvinylidene fluoride, polyvinylidene chloride, polyfluoroalkane, polyperfluoroalkane, polyacrylonitrile, polyvinyl ketone, polyvinyl aromatic hydrocarbons, polystyrene, polyvinyl ester, polyvinyl acetate, ethylene-methyl methacrylate copolymer, acrylonitrile-styrene copolymer, ABS resin and ethylene-vinyl acetate copolymer, polyamide, alkyd resin, polyoxymethylene, polyimide, polyether, polyacrylate, polymethyl methacrylate, poly(acrylic acid-co-maleic acid), chitosan, dextran, cellulose, heparin, alginate, inulin, starch or glycogen.Alternatively, it may include one or more selected from the group consisting of: hyaluronic acid, polyester, polyhydroxyalkanoates (PHAs), poly(α-hydroxyacid), poly(β-hydroxyacid), poly(3-hydroxybutyrate-co-hydroxyvalerate) (PHBV), poly(3-hydroxypropionate) (PHP), poly(3-hydroxyhexanoate) (PHH), poly(4-hydroxyacid), poly(4-hydroxybutyrate), poly(4-hydroxyvalerate), poly(4-hydroxyhexanoate), poly(esteramide), polycaprolactone, polylactide, polyglycolic acid, poly(lactide). Poly(glycolic acid-co-glycolic acid) (PLGA), polydioxanone, polyorthoesters, polyether esters, polyanhydrides, poly(glycolic acid-co-trimethylene carbonate), polyphosphates, polyphosphate urethanes, poly(amino acids), polycyanoacrylates, poly(trimethylene carbonate), poly(imino carbonate), poly(tyrosine carbonate), polycarbonate, poly(tyrosine aryl compounds), poly(alkylene oxalate), polyphosphates, phytohemagglutinin-polyethylene glycol (PHA-PEG), chitosan, dextran, cellulose, heparin, alginate, inulin, starch, and glycogen.

[0068] According to another embodiment, the first material may be a drug. Drug is a broad concept and can include not only therapeutic agents for therapeutic purposes in the narrow sense, but also energy, nanocomponents, cosmetic ingredients (e.g., anti-wrinkle agents, skin aging inhibitors, and skin whitening agents), cell culture media, etc. Specifically, therapeutic agents may include chemical drugs, protein / peptide drugs, peptide drugs, nucleic acid molecules for gene therapy, etc.

[0069] For example, therapeutic agents may include anti-inflammatory drugs, analgesics, anti-arthritis drugs, antispasmodics, antidepressants, antipsychotics, sedatives, anxiolytics, anesthetic antagonists, anti-Parkinson's drugs, cholinergic agonists, anticancer drugs, anti-angiogenic inhibitors and immunosuppressants, antiviral drugs, antibiotics, appetite suppressants, analgesics, anticholinergics, antihistamines, antimigraine drugs, hormones, coronary vasodilators, cerebral vasodilators or peripheral vasodilators, contraceptives, antithrombotic drugs, diuretics, antihypertensive drugs, and cardiovascular disease treatments, etc.

[0070] Specifically, protein / peptide drugs may include hormones, hormone analogs, enzymes, enzyme inhibitors, signal transduction proteins or portions thereof, antibodies or portions thereof, single-chain antibodies, binding proteins or their binding domains, antigens, attachment proteins, structural proteins, regulatory proteins, toxic proteins, cytokines, transcriptional regulatory factors, coagulation factors, and vaccines. More specifically, protein / peptide drugs may include insulin, insulin-like growth factor 1 (IGF-1), growth hormone, erythropoietin, granulocyte colony-stimulating factor (G-CSF), granulocyte / macrophage colony-stimulating factor (GM-CSF), interferon α, interferon β, interferon γ, interleukin-1 α and β, interleukin-3, interleukin-4, interleukin-6, interleukin-2, skin growth factor (EGF), calcitonin, adrenocorticotropic hormone (ACTH), tumor necrosis factor (TNF), atorbitan, sesquiterene, and cetrizoline. Cefuroxime, Desmopressin, Dysorcinol A (1-13), Ecalcitonin, Levodoxin, Etibatide, Growth Hormone Releasing Hormone-II (GHRH-II), Gonadorelin, Goserelin, Histamine Relin, Leuprorelin, Lysine Vasopressin, Octreotide, Oxytocin, Vasopressin, Secretin, Sincalli, Terlivasopressin, Thymopentin, Thymosin α1, Triptorelin, Diacerelin, Carbenicillin, Cyclosporine, Exetine, Lanreotide, Luteinizing Hormone Releasing Hormone (LHRH), Nafaline, Parathyroid Hormone, Pramlinide, Enft (T-20), Thymofasin, and Ziconopeptide.

[0071] In addition, energy can include thermal energy, light energy, electrical energy, etc. For example, the microstructures in photodynamic therapy can be used to induce light to specific parts of the human body, so that the light can act directly on the tissue or on intermediates such as photosensitive molecules.

[0072] Furthermore, the first material can be a water-soluble drug. The first material can be in a solid, liquid, powder, or highly concentrated state.

[0073] The second material can be a drug similar to the first material, a material capable of dissolving the first material, or a material capable of improving the delivery efficiency and speed of the first material.

[0074] When the second material is delivered to the human body together with the first material, various effects can be expected. Furthermore, the interaction between the first and second materials controls the dissolution rate of the first material in the human body, thereby maximizing efficacy. In addition, due to the adhesive strength of the second material, the multi-material delivery microsystem can maintain close contact with the skin.

[0075] According to one embodiment, the second material may include a fat-soluble material. Specifically, the second material may include one or more fat-soluble materials selected from the group consisting of horse oil, vitamin A and its derivatives, vitamin D and its derivatives, vitamin E and its derivatives, vitamin K and its derivatives, organic sunscreens, and fat-soluble plant extracts.

[0076] According to another embodiment, the second material may be a material capable of dissolving the first material or a material capable of rapidly adjusting the dissolution rate. Specifically, the second material may include one or more selected from the group consisting of water, anhydrous or hydrated lower alcohols of C1-C4, benzene, toluene, xylene, hexane, chloroform, ether, acetone, and amines.

[0077] According to another embodiment, the second material may include materials for protecting the skin. Specifically, the second material may include moisturizers, skin cleansers, disinfectants, skin repair agents, soothing agents, etc. Moisturizers may include glycerin, propylene glycol, sorbitol, amino acids, butylene glycol, hyaluronic acid, etc.; skin cleansers may include various polymer compounds, polyols, ester oils, oils and fats, silicone compounds, etc.; disinfectants may include C1-C4 lower alcohols, salicylic acid, camphor, etc.; and skin repair agents may include ceramides, almonds, organ plant oils, shea butter, etc.

[0078] The multi-material delivery microsystem 10 includes a microstructure 100, a material container 200, and a protective cover 300.

[0079] The microstructure 100 may be made using a first material, and the microneedles 120 are formed on one surface of the base film 110.

[0080] The base film 110 is configured as a film with a predetermined width and a thin thickness. The base film 110 can be configured in a circular or polygonal shape. The base film 110 can have a thickness of 1 mm. 2 Up to 200mm 2 Or 1mm 2 Up to 100mm 2 The width.

[0081] Microneedles 120 protrude from one surface of the basement membrane 110 at a predetermined height, and their ends are sharpened to facilitate penetration into the skin. According to an embodiment, the microneedles 120 may have 10 m to 20000 m, 10 m to 10000 m, 20 m to 10000 m, 30 m to 8000 m or 50 m to 2000 The height is m. Each region of the tip of the microneedle 120 can be set to have 1 m. m to 500 m、2 m to 300 m, or 5 m to 100 The minimum diameter of m and 50 m to 1000 The maximum diameter of m.

[0082] Microneedles 120 can be disposed at predetermined intervals on the remaining area of ​​one surface of the base film 110, excluding the area where the material receiving portion 200 is located. According to an embodiment, the microneedles 120 can be disposed around the central region of the base film 110. The microneedles 120 can be formed at a density of 1 to 5 needles / mm. 2 The density.

[0083] Skin barrier 130 may be formed in microstructure 100 along the edge region of basement membrane 110. Skin barrier 130 has an upper end above a surface of basement membrane 110 and a height below the end of microneedle 120.

[0084] The material receiving portion 200 provides a receiving space for receiving the second material 20. The material receiving portion 200 may be formed in the central region of the microstructure 100. According to an embodiment, the material receiving portion 200 may be integrally formed with the base film 110 in the central region of the base film 110. The bottom surface of the receiving space 221 of the material receiving portion 200 may be lower than a surface of the base film 110 on which the microneedles 120 are formed. The bottom surface of the receiving space 221 may have a downwardly recessed shape.

[0085] The width of the protective cap 300 corresponds to or is greater than the width of the microstructure 100, and covers the top of the microstructure 100 to prevent the microneedles 120 from being exposed to the outside. When the multi-material delivery microsystem 10 is stored, the protective cap 300 is combined with the microstructure 100, and during medical procedures, the protective cap 300 is removed from the microstructure 100.

[0086] Figure 3 This is a photographic illustration of a sample microstructure manufactured according to an embodiment of the present invention, and Figure 4 This is a sample photograph showing the state of the second material loaded on the material container of the microstructure.

[0087] Reference Figure 3 and Figure 4 It can be confirmed that the material receiving portion 200 is formed in a groove shape in the central region of the microstructure 100, and the second material 20 is loaded on the material receiving portion 200.

[0088] Figure 5 and Figure 6 The diagram sequentially illustrates the process of delivering a first material and a second material into the skin using a multi-material delivery microsystem according to an embodiment of the present invention.

[0089] Reference Figure 5 After removing the protective cap 300, the user presses the rear surface of the base membrane 110 with their finger while the multi-material delivery microsystem 10 is positioned such that the microneedles 120 are in contact with the skin 50. During this process, the microneedles 120 penetrate the skin 50, and the second material 20 contained in the material reservoir 200 diffuses through the space between the base membrane 110 and the skin 50 to the entire area of ​​the base membrane 110. The second material 20 is prevented from leaking out of the microstructure 100 because the skin isolation wall 130 compresses the peripheral area of ​​the skin.

[0090] Over time, the first material constituting the microneedle 120 dissolves and penetrates into the skin. The second material 20 penetrates into the skin along with the first material and promotes the dissolution of the first material. In addition, the second material 20 protects the skin surface penetrated by the microneedle 120 or inhibits the occurrence of irritation.

[0091] Figure 7 This is a cross-sectional view illustrating a multi-material delivery microsystem according to another embodiment of the present invention.

[0092] Reference Figure 7 A space 221 for storing the second material 20 is formed inside the material receiving portion 200. In addition, an opening 111 is formed in the central region of the base film 110.

[0093] The multi-material delivery microsystem 10 also includes an outflow prevention membrane 410, a diaphragm 420, and a stamping section 430.

[0094] The outflow prevention membrane 410 is a thin membrane that blocks the opening 111 of the base membrane 110. The outflow prevention membrane 410 is made of a material that is not dissolved by the second material 20, and it prevents the outflow of the second material 20. The outflow prevention membrane 410 may be made of a synthetic resin or rubber material.

[0095] A diaphragm 420 is located in the opening 111 of the base membrane 110 and is configured as a porous material. The diaphragm 420 controls the outflow rate of the second material 20. The second material 20 can be slowly introduced toward the microneedles 120 through the diaphragm 420. According to an embodiment, the diaphragm 420 may be made of ceramic or fibrous material.

[0096] The stamping part 430 opens the outflow prevention membrane 410 by user operation. The stamping part 430 includes a stamping rod 431, an elastic spring 432, and an operation button 433.

[0097] The stamping rod 431 has an end located in the internal space 221 of the material receiving portion 200 and has a sharp tip.

[0098] The elastic spring 432 is located outside the material receiving portion 200, and the stamping rod 431 is inserted into the elastic spring 432.

[0099] The operation button 433 is engaged with the upper end of the stamping rod 431.

[0100] When the user presses the operation button 433, the tip of the stamping rod 431 strikes the outflow prevention membrane 410 as it moves forward. As a result, a hole is formed in the outflow prevention membrane 410, and the second material 20 is introduced through this hole toward the diaphragm 420. Since the outflow rate is controlled, the second material 20 is absorbed by the diaphragm 420 and introduced toward the microneedles 120.

[0101] When the force of pressing the operation button 433 is removed, the stamping rod 431 moves to its initial position by the elastic force of the elastic spring 432.

[0102] When the second material 20 has high fluidity, the multi-material delivery microsystem 10 according to this embodiment can be used.

[0103] Figure 8 and Figure 9 This is a cross-sectional view illustrating a multi-material delivery microsystem according to another embodiment of the present invention.

[0104] Reference Figure 8 and Figure 9 Partition walls 220a, 220b, and 220c are formed in the material receiving section 200. Partition walls 220a to 220c divide the interior space of the material receiving section 200 into multiple spaces 221a, 221b, and 221c. Different materials of the aforementioned second material are disposed in each of spaces 221a to 221c.

[0105] The ends of the stamping rods 431a, 431b and 431c are divided into a number corresponding to the number of spaces 221a to 221c, and strike the outflow prevention membrane 410 in each space 221a to 221c.

[0106] As the outflow prevents impact on the membrane 410, the materials stored in the various spaces 221a to 221c flow out through the opening 111 and are absorbed into the diaphragm 420. After the various materials are mixed in the diaphragm 420, they are provided as a mixture to the microneedles 120.

[0107] The multi-material delivery microsystem 10 according to an embodiment of the present invention divides and stores materials whose effectiveness may be reduced or whose properties may be altered when they are stored as mixed materials in separate spaces 221a to 221c, and generates mixed materials when the materials penetrate into the skin.

[0108] Figure 10 This is a perspective view illustrating a multi-material delivery microsystem according to another embodiment of the present invention. Figure 11 It is shown Figure 10 An exploded stereoscopic view of a multi-material delivery microsystem, and Figure 12 It is shown Figure 10 Cross-sectional view of a multi-material delivery microsystem.

[0109] Reference Figures 10 to 12 When the second material 20 is a material that dissolves the first material, if the second material 20 is stored in a state of contact with the microstructure 100, the microstructure 100 may dissolve. To prevent this, the second material 20 needs to be separated from the microstructure 100.

[0110] The multi-material delivery microsystem 10 according to an embodiment of the present invention includes a microstructure 100 and a material receiving portion 200.

[0111] The microstructure 100 is made using the first material described above and includes a base film 110 and microneedles 120.

[0112] The base film 110 may have Figure 1 The thickness and width are described in the embodiments. One surface of the base film 110 includes a central region and a peripheral region.

[0113] An opening 111 is formed in the central region of the base film 110. A peripheral region surrounds the central region and forms microneedles 120. The microneedles 120 have... Figure 1 The structure and dimensions of the microneedles described in the text are the same.

[0114] The material receiving portion 200 is disposed separately from the microstructure 100 and is made of a material that is not dissolved by the second material 20. According to an embodiment, the material receiving portion 200 may be made of a flexible and human-friendly material. The material receiving portion 200 may be made of synthetic resin, silicone, or rubber.

[0115] The material receiving section 200 includes a support plate 210, a partition wall 220, and a skin isolation wall 230.

[0116] The support plate 210 is configured as a thin plate with a width and shape corresponding to the width and shape of the base film 110.

[0117] A partition wall 220 is formed in the central region of the support plate 210. The partition wall 220 is an annular shape with an outer diameter corresponding to the opening 111 of the base film 110, and is disposed at a predetermined height from a surface of the support plate 210. The internal space of the partition wall 220 is configured as a receiving space 221 capable of accommodating the second material 20. The bottom surface of the receiving space 221 may be configured as a concave curved surface. When the microstructure 100 is placed on a surface of the support plate 210, the partition wall 220 is inserted into the opening 111 of the base film 110. Furthermore, the upper end of the partition wall 220 is higher than a surface of the base film 110 and has a height lower than the height of the end of the microneedle 120.

[0118] The skin isolation wall 230 is positioned at a predetermined height along the edge region of the support plate 210. The upper end of the skin isolation wall 230 is above a surface of the base membrane 110, and its height is below the height of the end of the microneedle 120. The skin isolation wall 230 may have various widths in the radial direction of the support plate 210. Furthermore, one side surface of the skin isolation wall 230 facing the separator 220 may be configured as a curved surface.

[0119] Figure 13 It shows the use according to Figure 12 An illustration of the process by which a multi-material delivery microsystem of an embodiment inserts microneedles into the skin.

[0120] First, refer to Figure 12 The second material 20 is stored in a state where its contact with the microstructure 100 is blocked by the partition wall 220 of the material receiving portion 200. Therefore, during storage, the microstructure 100 can maintain its initial appearance without being dissolved.

[0121] Reference Figure 13 When a user wants to insert the microneedle 120 into the skin 50, the microneedle 120 is penetrated into the skin by pressing the rear surface of the support plate 210 while the microstructure 100 is in contact with the skin 50. During this process, the second material 20 flows out through the gap between the skin 50 and the septum 220 and diffuses toward the microneedle 120. Furthermore, leakage is prevented by squeezing the skin septum 230 in the surrounding area. The second material 20 contacts the microneedle 120 to promote its disintegration. Therefore, the first material can penetrate the skin 50 in a short time.

[0122] Figure 14 This is a cross-sectional view illustrating a partition wall structure according to another embodiment of the present invention, and Figure 15 It is shown Figure 14 A diagram showing the appearance of the deformed partition wall structure.

[0123] Reference Figure 14The partition wall 220 may have a thin thickness and may have corrugations formed in the height direction. In the corrugated expanded state, the upper end of the partition wall 220 is located at a first height and accommodates the second material in the internal accommodating space 221.

[0124] Reference Figure 15 During the insertion of the microneedle 120 into the skin 50, the septum 220 presses against the skin 50 and contracts. Therefore, the upper end of the septum 220 is located at a second height below the first height, and the second material can easily diffuse through the gap between the skin 50 and the septum 220.

[0125] Figure 16 This is a cross-sectional view illustrating a partition wall structure according to another embodiment of the present invention, and Figure 17 It is shown Figure 16 A diagram showing the appearance of the deformed partition wall structure.

[0126] Reference Figure 16 The partition wall 220 has multiple annular partition wall layers 225, 226, and 227 in a multi-level stacked structure. At least two partition wall layers 225 to 227 may be provided. In this embodiment, three partition wall layers 225 to 227 are described as an example.

[0127] The first partition wall layer 225 has an annular shape and is located at the upper end of the partition wall 220.

[0128] The second partition wall layer 226 is located below the first partition wall layer 225 and forms a space therein that can accommodate the first partition wall layer 225.

[0129] The third partition wall layer 227 is located below the second partition wall layer 226 and forms a space therein capable of accommodating the second partition wall layer 226. The third partition wall layer 227 is attached to one surface of the support plate 210.

[0130] The partition wall 220 can switch between a first state and a second state. The first state is a state where the first partition wall layer 225 to the third partition wall layer 227 are stacked sequentially, and the upper end of the first partition wall layer 225 is located at a first height. In the second state, the first partition wall layer 225 is located within the internal space of the second partition wall layer 226, and the second partition wall layer 226 is located within the internal space of the third partition wall layer 227. Therefore, the upper end of the partition wall 220 has a second height lower than the first height, that is, the same height as the upper end of the third partition wall layer 227.

[0131] In its first state, the septum 220 contains the second material 20. Furthermore, during the insertion of the microneedle 120 into the skin 50, the microneedle 120 is pressed against the skin 50 and transitions to the second state. In the second state, the second material 20 can readily diffuse through the gap between the skin 50 and the septum 220.

[0132] Figure 18 This is a cross-sectional view illustrating a partition wall structure according to another embodiment of the present invention, and Figure 19 It is shown Figure 18 A diagram showing the appearance of the deformed partition wall structure.

[0133] Reference Figure 18 and Figure 19 The diameter and thickness of the partition wall 220 gradually decrease from its lower end to its upper end adjacent to the support plate 210. The lower end of the partition wall 220 has a first diameter, and the upper end has a second diameter smaller than the first diameter. Typically, the partition wall 220 has a dome structure. The second material 20 is accommodated inside the partition wall 220.

[0134] During the insertion of the microneedle 120 into the skin 50, the septum 220 is continuously pressed against the skin 50 from the top. As a result, the septum 220 bends toward the receiving space 221. Because the upper end of the septum 220 is set to a thin thickness, it can be easily pressed with a small force. During this process, the second material 20 can easily diffuse through the gap between the skin 50 and the septum 220.

[0135] Figure 20 This is a cross-sectional view illustrating a partition wall structure according to another embodiment of the present invention, and Figure 21 It is shown Figure 20 A diagram showing the appearance of the deformed partition wall structure.

[0136] Reference Figure 20 and Figure 21 The diameter of the partition wall 220 gradually increases from its lower end to its upper end adjacent to the support plate 210, while its thickness gradually decreases. The lower end of the partition wall 220 has a first diameter, and its upper end has a second diameter larger than the first diameter. The second material 20 is accommodated inside the partition wall 220.

[0137] During the insertion of the microneedle 120 into the skin 50, the skin 50 is continuously pressed from the upper end of the septum 220. The septum 220 bends outward from the receiving space 221, making its upper diameter larger. Because the upper end of the septum 220 is set to a thin thickness, it can be easily pressed with a small force. During this process, the second material 20 can easily diffuse through the gap between the skin 50 and the septum 220.

[0138] Figure 22This is a diagram displayed on the XY plane, illustrating a partition wall structure according to another embodiment of the invention, and Figure 23 It is shown Figure 22 A diagram showing the appearance of the deformed partition wall structure.

[0139] Reference Figure 22 and Figure 23 The partition wall 220 is provided by combining the support portion 228 and the connecting portion 229.

[0140] The support portion 228 is an arc-shaped plate with a predetermined length, and multiple arc-shaped plates are arranged sequentially at intervals from each other along the outer periphery of the receiving space 221.

[0141] Connecting portion 229 connects two sides of adjacent support portions 228 between support portions 228. The thickness of connecting portion 229 is thinner than the thickness of support portion 228 (specifically, along the outer periphery of receiving space 221, the thickness of connecting portion 229 is thinner than the thickness of support portion 228). Connecting portion 229 has a thickness sufficient to be easily torn apart when an external force is applied.

[0142] As described above, the partition wall 220 is configured as a combination of the support portion 228 and the connecting portion 229, and the second material 20 is accommodated in the accommodating space 221.

[0143] During the insertion of the microneedle 120 into the skin 50, the upper end of the support portion 228 is compressed by the skin 50 and bends outward toward the receiving space 221. During this process, the connecting portion 229 is torn open, and the second material 20 is introduced toward the microneedle 120 through the space between the supports 228.

[0144] Figure 24 This is a cross-sectional view illustrating a multi-material delivery microsystem according to another embodiment of the present invention, and Figure 25 It is shown Figure 24 A diagram illustrating the usage status of a multi-material delivery microsystem.

[0145] Reference Figure 24 A storage space 211 capable of storing the second material 20 is formed inside the support plate 210. The bottom surface of the storage space 211 may be flat. The storage capacity of the second material 20 can be increased by forming a separate storage space 211 inside the support plate 210. Furthermore, an opening 212 is formed in the central region of the support plate 210, and a partition wall 220 is formed in the central region of the support plate 210. The opening 212 connects the storage space 211 and the receiving space 221 inside the partition wall 220, and provides a channel through which the second material 20 stored in the storage space 211 can flow out.

[0146] Reference Figure 25Since the support plate 210 is made of a flexible material, when the user presses the bottom surface of the support plate 210, the bottom surface deforms toward the opening 211. This facilitates the outflow of the second material 20 stored in the storage space 211 through the opening 212.

[0147] Figure 26 This is a cross-sectional view illustrating a multi-material delivery microsystem according to another embodiment of the present invention.

[0148] Reference Figure 26 ,and Figure 24 In different embodiments, the bottom surface of the storage space 211 may be configured as a concave curved surface. The concave curved surface facilitates the flow of the second material 20 toward the opening 212.

[0149] Figure 27 This is a cross-sectional view illustrating a multi-material delivery microsystem according to another embodiment of the present invention.

[0150] Reference Figure 27 The support plate 210 is configured as a curved surface, wherein the bottom surface 210a of the area where the partition wall 220 is located protrudes downward. The bottom surface 210a can be set at various depths depending on the storage capacity of the second material 20. The user can press the bottom surface 210a to supply the second material 20 toward the microneedle 120.

[0151] Figure 28 This is a cross-sectional view illustrating a multi-material delivery microsystem according to another embodiment of the present invention, and Figure 29 It is shown Figure 28 A diagram illustrating the operation of a multi-material delivery microsystem.

[0152] Reference Figure 28 and Figure 29 In the support plate 210, the bottom surface of the region forming the storage space is set as a membrane with a thin thickness.

[0153] The multi-material delivery microsystem 10 also includes a pusher 240. The pusher 240 can be inserted into the storage space 211. When the user pushes the tip of the pusher 240 against the bottom surface of the storage space 211, the bottom surface, which is configured as a film, is torn open, and the pusher 240 is inserted into the storage space 211. The second material 20 stored in the storage space 211 can be pushed by the pusher 240 and supplied toward the microneedle 120.

[0154] Figures 30 to 32 This is a plan view showing the microstructure according to various embodiments.

[0155] First, refer to Figure 30As described in the above embodiments, the opening 111 is formed in the central region of the base film 110, but multiple openings 111 may be formed in various regions. In addition, microneedles 120 may be formed in the peripheral regions where no openings 111 are formed.

[0156] Reference Figure 31 The base film 110 can be configured in a rectangular or circular shape. According to an embodiment, the base film 110 can be configured in a rectangular shape. Furthermore, a plurality of openings 111 can be formed to be spaced apart from each other along the longitudinal direction of the base film 110.

[0157] Reference Figure 32 The opening 111 can be formed as a slit shape in the longitudinal direction of the base film 110.

[0158] The invention has been described in detail above using preferred embodiments, but the scope of the invention is not limited to the specific embodiments and should be interpreted in accordance with the appended claims. Furthermore, those skilled in the art will understand that many modifications and variations are possible without departing from the scope of the invention.

[0159] Industrial applicability

[0160] The microstructures according to the present invention can be used for medical treatment and skin care.

Claims

1. A multi-material delivery microsystem, comprising: A microstructure in which microneedles are formed on one surface of a base film, and the microstructure is made of a first material; as well as A material receiving portion, located in a region of the microstructure, and having a receiving space for a second material different from the first material. The material receiving portion further includes an annular partition wall that surrounds the receiving space and is positioned such that the upper end of the partition wall is lower than the tip of the microneedle.

2. The multi-material delivery microsystem according to claim 1, wherein, The base film has a surface, the surface comprising: Central region; and A peripheral region, the peripheral region surrounding the central region and in which the microneedles are formed, and The material receiving portion is located in the central region of the base film.

3. The multi-material delivery microsystem according to claim 2, wherein, The accommodating space is positioned such that the center of the bottom surface of the accommodating space is lower than one surface of the base film.

4. The multi-material delivery microsystem according to claim 1, wherein, The partition wall is configured as a corrugated wall, the corrugated wall having an upper end, the upper end being located at a first height in an expanded state and at a second height below the first height in a contracted state.

5. The multi-material delivery microsystem according to claim 1, wherein, The partition wall includes: The first partition wall layer is in the shape of an annular ring; and A second partition wall layer is located below the first partition wall layer, and a space is formed within the second partition wall layer that can accommodate the first partition wall layer. The first partition wall layer and the second partition wall layer can switch between a first state and a second state. In the first state, the first partition wall layer and the second partition wall layer are stacked in multiple levels. In the second state, the first partition wall layer is located inside the second partition wall layer.

6. The multi-material delivery microsystem according to claim 1, wherein, The partition wall includes: The support portions are positioned sequentially and spaced apart from each other along the outer periphery of the receiving space; and A connecting portion, which is located between the supporting portions and has a thickness thinner than that of the supporting portions.

7. The multi-material delivery microsystem according to claim 1, wherein, The diameter and thickness of the partition wall gradually decrease from the lower end of the partition wall to the upper end of the partition wall.

8. The multi-material delivery microsystem according to claim 1, wherein, As the partition wall extends from its lower end to its upper end, the diameter of the partition wall gradually increases and the thickness of the partition wall gradually decreases.

9. The multi-material delivery microsystem according to claim 1, wherein, The material receiving portion further includes a support plate located on the bottom of the base film, and the material receiving portion also has a partition wall integrally formed in its central region.

10. The multi-material delivery microsystem according to claim 9, wherein, The support plate has an internal portion in which a storage space for storing the second material is formed, and an opening is formed connecting the storage space and the receiving space.

11. The multi-material delivery microsystem according to claim 9, wherein, The support plate has a storage space connected to and formed therein with the receiving space, the bottom surface of the storage space being configured as a film of thin thickness, and the material receiving portion further includes a pushing portion that presses against the bottom surface of the storage space and is inserted into the storage space to push the second material stored in the storage space.

12. The multi-material delivery microsystem according to claim 9, wherein, The support plate has a storage space connected to and formed therein, the bottom surface of the storage space being configured to bulge downward and have a thin membrane, and when the bottom surface of the storage space is pressed from the outside, the bottom surface of the storage space is pressed against the receiving space.

13. The multi-material delivery microsystem according to claim 1, further comprising: A diaphragm forms a plurality of storage spaces separated by partition walls in the material receiving portion, and the diaphragm is located in the opening of the base membrane; An outflow prevention membrane blocks the opening formed in the base membrane and is located between the storage space and the diaphragm; as well as A stamping rod, with multiple ends respectively located in each of the storage spaces, and the stamping rod capable of impacting the outflow prevention membrane. Different materials are stored in each of the storage spaces, and the various materials are introduced into the diaphragm and mixed with each other through pores formed in the outflow prevention membrane by the impact of the stamping rod.

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