Artificial cerebrospinal fluid proportioning device and container

Abstract

The present invention belongs to the technical field of artificial cerebrospinal fluid proportioning, and specifically relates to an artificial cerebrospinal fluid proportioning device and a container, comprising an installation box and a mixed gas supply device, wherein the lower end of the installation box is rotatably connected to a mounting column, a solution mixer is symmetrically installed inside the installation column, a circular plate is fixedly connected inside the protective cylinder, the circular plate is fixedly connected to a cylinder, a first spring is fixedly installed at the lower end of the circular plate, an abutment ring is fixedly installed at the lower end of the first spring, an outer gear ring is sleeved on the outer side of the cylinder, the cylinder is threadedly connected to the container, a gear ring cylinder is fixedly connected to the outer side of the installation column, a threaded rod is slidably connected to the middle part of the installation column, a sealing cylinder is fixedly connected inside the installation box, a torsion spring box is installed on the upper side of the inner side of the sealing cylinder, a rotating rod is fixedly connected to the output end of the torsion spring box, and a piston is fixedly connected to the upper end of the threaded rod; the present invention can clean the unused solution mixer during the process of connecting the container to the solution mixer, so as to avoid affecting the subsequent mixing of artificial cerebrospinal fluid after the raw materials are mixed.

Description

Technical Field

[0001] The invention belongs to the technical field of sampling devices, and in particular relates to an artificial cerebrospinal fluid proportioning device and a container. Background Art

[0002] Artificial cerebrospinal fluid (ACSF) is a colorless, transparent liquid that simulates the human cerebrospinal fluid environment and is also known as CSF simulant. It is a sterile solution sterilized using a 0.22μm sterile filter and can be used directly. Its ion concentration, pH, and osmotic pressure are similar to those of human CSF, avoiding many of the side effects of saline perfusion. This makes it a safer irrigation or lavage solution in clinical practice, or a supplement for CSF loss. It is commonly used as a CSF substitute to protect interneurons during brain slice perfusion. In research, ACSF is often used to maintain pH balance and tissue oxygen delivery, conduct microdialysis experiments in rat brains, and culture hippocampal tissue slices. It has also been used to locally irrigate traumatic brain lesions in rats to study their therapeutic effects.

[0003] However, since some components in artificial cerebrospinal fluid (such as calcium, glucose, sodium bicarbonate, etc.) are easily precipitated and hydrolyzed with each other and cannot be preserved for a long time, and the use of artificial cerebrospinal fluid has very high requirements for pH, electrolyte concentration, blood gas status and sterile conditions, most of the time when artificial cerebrospinal fluid is needed, the raw materials in corresponding proportions are manually extracted and mixed. However, some components in artificial cerebrospinal fluid (such as calcium, glucose, sodium bicarbonate, etc.) are easily precipitated and hydrolyzed after mixing and cannot be preserved for a long time. Therefore, the mixer needs to be cleaned each time the raw materials are mixed, which increases the operating steps in the user's mixing process and causes inconvenience to the user. Therefore, there is room for improvement. Summary of the Invention

[0004] The purpose of the present invention is to provide an artificial cerebrospinal fluid proportioning device and container, which can aspirate cleaning fluid to clean the solution mixer without using external equipment during the connection process of the solution mixer, thereby preventing the cerebrospinal fluid raw material mixture from remaining inside the solution mixer and affecting subsequent preparation. At the same time, when artificial cerebrospinal fluid needs to be prepared, there is no need to manually mix multiple raw materials together, thus saving mixing time, and being easy to operate and saving resources.

[0005] In order to achieve the above technical objectives, the technical solutions adopted by the present invention are as follows:

[0006] An artificial cerebrospinal fluid proportioning device comprises a mounting box and a mixed gas supply device, wherein two raw material storage boxes are installed inside the mounting box, and discharge pipes are installed at the lower ends of the two raw material storage boxes, the mixed gas supply device is installed outside the mounting box, and an air outlet pipe is installed at the output end of the mixed gas supply device, the lower end of the mounting box is rotatably connected to a mounting column, a solution mixer is symmetrically installed inside the mounting column, an inlet matching two discharge pipes and one air outlet pipe is opened at the upper end of the solution mixer, a protective cylinder located outside the mounting column is installed at the lower end of the mounting box, a circular plate is fixedly connected to the inside of the protective cylinder by a connecting rod, the circular plate is fixedly connected to a cylinder matching the solution mixer, a first spring is fixedly installed at the lower end of the circular plate, and an abutment ring is fixedly installed at the lower end of the first spring;

[0007] The outer side of the cylinder is provided with an outer gear ring, and the cylinder is threadedly connected to a container matching the solution mixer, and the outer side of the mounting column is fixedly connected to a gear ring cylinder meshing with the outer gear ring, and a limiting assembly is provided between the outer gear ring and the protective cylinder, and the limiting assembly is provided with a limit groove matching the container, the middle of the mounting column is connected to a threaded rod for sliding up and down, and a one-way rotation assembly is provided between the threaded rod and the mounting column, a sealing cylinder threadedly connected to the threaded rod is fixedly connected to the interior of the mounting box, and a torsion spring box is installed on the upper side of the sealing cylinder, and the output end of the torsion spring box is fixedly connected to a rotating rod connected to the threaded rod for sliding up and down, the upper end of the threaded rod is fixedly connected to a piston that is sealingly and slidingly connected to the rotating rod and the sealing cylinder, and the lower end of the piston is connected to a one-way output pipe connected to the solution mixer, a cleaning liquid storage tank is installed inside the mounting box, and the upper side of the sealing cylinder is connected to a one-way inlet pipe connected to the cleaning liquid storage tank, a one-way air release assembly is installed on the upper side of the sealing cylinder, and a waste collection assembly is provided at the lower end of the protective cylinder.

[0008] The solution mixer includes a mixing column installed inside a mounting column, wherein the upper end of the mixing column is symmetrically provided with spiral grooves, and the two spiral grooves rotate in opposite directions, an annular groove connected to the two spiral grooves is provided in the center of the mixing column, an air inlet groove connected to the two spiral grooves is provided at the upper end of the mixing column, and a liquid outlet groove connected to the annular groove is provided at the lower end of the mixing column.

[0009] There are three air inlet grooves, which are respectively connected to the three connection points of the two spiral grooves. There are several liquid outlet grooves, which are inclined from the annular groove to the lower center, and the middle parts of the several liquid outlet grooves are connected to each other.

[0010] The limiting assembly includes a ratchet fixedly connected to the lower end of the outer gear ring, a travel groove matching the ratchet is opened on the lower side of the inner part of the protective tube, a pawl is elastically hinged on the bottom side of the inner part of the travel groove through a torsion spring, and the limit groove is opened at the lower end of the ratchet.

[0011] The one-way air release assembly includes a one-way exhaust pipe connected to the upper side of the sealing cylinder, the lower end of the one-way exhaust pipe is fixedly connected to an air bag, and the lower end of the air bag is connected to a blowing pipe.

[0012] The waste collection assembly includes two waste pipes, one of which matches the one-way air release assembly, and the other waste pipe is symmetrically arranged with the container. A waste box is installed on the lower side of the installation box body, and the two waste pipes are connected to the waste box through a connecting pipe.

[0013] The one-way rotation assembly includes a rotating block fixedly connected to the threaded rod, a plurality of mounting slots are opened inside the mounting column, a third spring is installed inside a plurality of the mounting slots, and a trapezoidal block fixedly connected to the third spring is slidably connected inside a plurality of the mounting slots.

[0014] The container includes a storage bag, the upper end of the storage bag is fixedly connected to a feed pipe, a sliding groove is provided inside the feed pipe, a ring plate is slidably connected inside the sliding groove, a second spring is fixedly installed on the upper end of the ring plate, a threaded cylinder threadedly connected to the cylinder is slidably connected inside the sliding groove, a slider matching the limiting groove is fixedly connected to the upper end of the feed pipe, a liquid outlet pipe is provided at the lower end of the storage bag, and a sealing cover is threadedly connected to the threaded cylinder.

[0015] The present invention can aspirate the cleaning liquid to clean the solution mixer without using external equipment during the connection process of the solution mixer, thereby preventing the cerebrospinal fluid raw material mixture from remaining inside the solution mixer and affecting subsequent preparation. At the same time, when artificial cerebrospinal fluid needs to be prepared, there is no need to manually configure multiple raw materials to mix together, thus saving mixing time, and also being easy to operate and saving resources. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The present invention is further illustrated by means of the following non-limiting examples.

[0017] Figure 1 This is a schematic structural diagram of an artificial cerebrospinal fluid proportioning device according to the present invention;

[0018] Figure 2 This is a schematic diagram of a first cross-sectional structure of an artificial cerebrospinal fluid proportioning device according to the present invention;

[0019] Figure 3 This is a schematic diagram of a second cross-sectional structure of an artificial cerebrospinal fluid proportioning device according to the present invention;

[0020] Figure 4 for Figure 3 Schematic diagram of the enlarged structure at A in the middle;

[0021] Figure 5This is a schematic diagram of the third cross-sectional structure of an artificial cerebrospinal fluid proportioning device of the present invention;

[0022] Figure 6 for Figure 5 Schematic diagram of the enlarged structure at B in the middle;

[0023] Figure 7 This is a schematic diagram of the fourth cross-sectional structure of an artificial cerebrospinal fluid proportioning device of the present invention;

[0024] Figure 8 for Figure 7 Schematic diagram of the enlarged structure at C in the middle;

[0025] Figure 9 It is a schematic diagram of the cross-sectional structure of the container of the present invention.

[0026] The main component symbols are described as follows:

[0027] Installation box 1, mixed gas supply equipment 11, raw material storage box 12, discharge pipe 13, outlet pipe 14, installation column 15, solution mixer 16, protective cylinder 17, circular plate 18, cylinder 19, first spring 20, abutment ring 21, outer gear ring 22, container 23, gear ring cylinder 24, threaded rod 25, rotating block 251, third spring 252, trapezoidal block 253, sealing cylinder 26, torsion spring box 27, rotating rod 28, piston 29, single To the output pipe 30, the cleaning liquid storage tank 31, the one-way inlet pipe 32, the mixing column 40, the spiral groove 41, the annular groove 42, the air inlet groove 43, the liquid outlet groove 44, the ratchet 45, the stroke groove 46, the pawl 47, the one-way exhaust pipe 48, the air bag 49, the blowing pipe 50, the waste pipe 51, the waste box 52, the storage bag 60, the feed pipe 61, the ring plate 62, the second spring 63, the threaded cylinder 64, the slider 65, the liquid outlet pipe 66, and the sealing cover 67. DETAILED DESCRIPTION

[0028] In order to enable those skilled in the art to better understand the present invention, the technical solution of the present invention is further described below with reference to the accompanying drawings and embodiments.

[0029] Example 1:

[0030] like Figure 1-9As shown, an artificial cerebrospinal fluid proportioning device of the present invention includes a mounting box 1 and a mixed gas supply device 11, two raw material storage boxes 12 are installed inside the mounting box 1, and the lower ends of the two raw material storage boxes 12 are installed with a discharge pipe 13, the mixed gas supply device 11 is installed on the outside of the mounting box 1, and the output end of the mixed gas supply device 11 is installed with an outlet pipe 14, the lower end of the mounting box 1 is rotatably connected to a mounting column 15, and a solution mixer 16 is symmetrically installed inside the mounting column 15, and an inlet matching the two discharge pipes 13 and the one outlet pipe 14 is opened at the upper end of the solution mixer 16, a protective cylinder 17 located outside the mounting column 15 is installed at the lower end of the mounting box 1, and a circular plate 18 is fixedly connected to the inside of the protective cylinder 17 through a connecting rod, and the circular plate 18 is fixedly connected to a cylinder 19 matching the solution mixer 16, and a first spring 20 is fixedly installed at the lower end of the circular plate 18, and an abutment ring 21 is fixedly installed at the lower end of the first spring 20;

[0031] The outer side of the cylinder 19 is provided with an outer gear ring 22, and the cylinder 19 is threadedly connected to a container 23 that matches the solution mixer 16. The outer side of the mounting column 15 is fixedly connected to a gear ring cylinder 24 that meshes with the outer gear ring 22. A limiting component is provided between the outer gear ring 22 and the protective cylinder 17. The limiting component is provided with a limiting groove that matches the container 23. A threaded rod 25 is connected to the middle part of the mounting column 15 for sliding up and down. A one-way rotation component is provided between the threaded rod 25 and the mounting column 15. A sealing cylinder 26 that is threadedly connected to the threaded rod 25 is fixedly connected to the inside of the mounting box 1. The sealing cylinder 26 is provided on the inside. A torsion spring box 27 is installed on the side, and the output end of the torsion spring box 27 is fixedly connected to a rotating rod 28 that is slidably connected to the threaded rod 25 up and down, and the upper end of the threaded rod 25 is fixedly connected to a piston 29 that is sealed and slidably connected to the rotating rod 28 and the sealing cylinder 26. The lower end of the piston 29 is connected to a one-way output pipe 30 connected to the solution mixer 16, and a cleaning liquid storage tank 31 is installed inside the installation box 1. The upper side of the sealing cylinder 26 is connected to a one-way inlet pipe 32 that is connected to the cleaning liquid storage tank 31, a one-way air release component is installed on the upper side of the sealing cylinder 26, and a waste collection component is provided at the lower end of the protective cylinder 17.

[0032] The proportioning device is equipped with a controller. At the same time, the discharge pipes 13 of the two raw material storage boxes 12 and the mixed gas supply device 11 are electrically connected to the controller. At the same time, the controller can control the discharge amount of the discharge pipe 13 and the gas outlet pipe 14, so that the raw materials of appropriate proportions enter the solution mixer 16 for mixing. The mixed gas supply device 11 can output 95% oxygen and 5% carbon dioxide required for the preparation of artificial cerebrospinal fluid from the output end and mix them with the raw materials. The two raw material storage boxes 12 respectively store alkaline electrolyte solutions containing sodium bicarbonate, and storing an acidic electrolyte solution containing glucose, so that a variety of mixed raw materials can be stored inside the two raw material storage boxes 12 without being easily deteriorated. In the initial state, the elastic force of the first spring 20 drives the abutment ring 21 to move downward, thereby causing the outer gear ring 22 abutting against the abutment ring 21 to move downward until it abuts against the limiting component, thereby making the outer gear ring 22 only able to rotate in one direction. At this time, the cylinder 19 is located below the solution mixer 16 and is not abutting against it. At the same time, the piston 29 is located on the upper side of the sealing cylinder 26, and the torsion spring inside the torsion spring box 27 is in a natural state.

[0033] When artificial cerebrospinal fluid needs to be mixed and proportioned, a container 23 of appropriate capacity is selected according to the required volume of artificial cerebrospinal fluid and is moved toward the connection point between the protective cylinder 17 and the solution mixer 16, so that the inlet of the container 23 matches the limiting groove of the limiting component, and then the elastic force of the first spring 20 is overcome to push the container 23 upward to release the limiting component from one-way rotation, and the outer gear ring 22 moves upward on the outside of the cylinder 19, and then drives the container 23 to rotate. Since the container 23 matches the limiting groove, when the container 23 rotates, it will drive the outer gear ring 22 and the one-way rotating The outer gear ring 22 drives the gear ring cylinder 24 meshing with it to rotate. Since the cylinder 19 is fixedly connected, the container 23 will be threadedly connected with it when it rotates until the container 23 completes the threaded connection with the cylinder 19. At this time, the outer gear ring 22 drives the gear ring cylinder 24 to rotate 180 degrees, thereby rotating the other solution mixer 16 to match the container 23, so that the container 23 can be connected to the solution mixer 16. At this time, the controller starts the two discharge pipes 13 and the air outlet pipe 14 to flow out the corresponding proportion of raw materials into the solution mixer 16 for mixing, and then flows into the container 23 from its output end until the mixing ratio is completed. When the force is removed after the container 23 is threadedly connected to the cylinder 19, the rebound force of the first spring 20 will drive the outer gear ring 22 to move downward, thereby connecting it to the limiting component, and then drive the container 23 to rotate in the opposite direction to release the threaded connection with the cylinder 19.

[0034] When the threaded rod 25 is rotated and moves downward, the one-way rotating component plays a limiting role, thereby causing the threaded rod 25 and the rotating rod 28 to rotate when the mounting post 15 rotates. When the threaded rod 25 is rotated and moves upward, the one-way rotating component releases the abutment, and there are magnets that attract each other between the lower side of the mounting post 15 and the container 23, thereby causing the mounting post 15 to be magnetically attracted by the container 23 and not rotate. At this time, since the threaded rod 25 is threadedly connected to the sealing cylinder 26, the threaded rod 25 will drive the piston 29 to move downward when it rotates, and the rotating rod 28 will store force inside the torsion spring box 27 when it rotates. Since the one-way degassing component can only exhaust and the one-way output pipe 3 can only output to the outside from the sealing cylinder 26, a negative pressure is formed inside the sealing cylinder 26 during the downward movement of the piston 29, thereby releasing the cleaning liquid inside the one-way inlet pipe 32 connected to it. The suction enters the interior of the sealing cylinder 26, and during the rotation of the mounting post 15, the mounting box 1 will close the input end of the solution mixer 16, thereby causing the one-way output pipe 30 to also form a closed state, until the mounting post 15 rotates 180°, the threaded rod 25 and the piston 29 stop moving, and at this time the solution mixer 16 that is rotated to match the one-way output pipe 30 is connected to it, and at the same time, the torsion spring inside the torsion spring box 27 that has accumulated power will drive the rotating rod 28 and the threaded rod 25 to rotate and move upward under the action of the rebound force, while when the one-way rotating component is rotated, the threaded rod 25 rotates by itself and cannot drive the mounting post 15 to rotate, so the mounting post 15 remains stationary, and during the upward movement of the piston 29, the cleaning liquid inside the sealing cylinder 26 will be transported to the unconnected solution mixer 16 for cleaning, and at the same time, the threaded rod 25 will return to its initial state for convenient next use.

[0035] The present invention can clean the solution mixer 16 by sucking out the cleaning liquid without using any external equipment during the process of connecting the solution mixer 16, thereby preventing the cerebrospinal fluid raw material mixture from remaining inside the solution mixer 16 and affecting the subsequent preparation. At the same time, when artificial cerebrospinal fluid needs to be prepared, there is no need to manually mix multiple raw materials together, thus saving the mixing time, and the operation is convenient and resource-saving.

[0036] The limiting component includes a ratchet 45 fixedly connected to the lower end of the outer toothed ring 22, and a travel groove 46 matching the ratchet 45 is provided on the lower side of the inner part of the protective tube 17. A pawl 47 is elastically hinged to the bottom side of the travel groove 46 through a torsion spring, and a limit groove is provided at the lower end of the ratchet 45; in the initial state, the ratchet 45 abuts against the travel groove 46, and the pawl 47 is inserted between the adjacent meshing teeth of the ratchet 45 in the natural state of the torsion spring. At this time, the outer toothed ring 22 is located on the lower side of the toothed ring tube 24 and is not meshed. When the container 23 moves upward, it will be inserted into the limit groove and drive the ratchet 45 and the outer toothed ring The upward movement of the ring 22 will cause the outer gear ring 22 to engage with the gear ring cylinder 24, thereby driving the gear ring cylinder 24 to rotate. After the connection is completed, the rebound force of the first spring 20 will drive the outer gear ring 22 to return to its initial state. At the same time, the container 23 is always in contact with the solution mixer 16 at this time. In this way, when the threaded connection of the container 23 is released, the outer gear ring 22 will not drive the gear ring cylinder 24 to rotate, and the characteristics of the ratchet 45 and the pawl 47 can rotate in one direction, so that the ratchet 45 can rotate in one direction under the restriction of the pawl 47, and at the same time, the threaded connection between the container 23 and the cylinder 19 is released.

[0037] The one-way rotating assembly includes a rotating block 251 fixedly connected to the threaded rod 25, a plurality of mounting grooves are opened inside the mounting column 15, a third spring 252 is installed inside the plurality of mounting grooves, and a trapezoidal block 253 fixedly connected to the third spring 252 is slidably connected inside the plurality of mounting grooves; in the initial state, the vertical surface of the rotating block 251 is parallel to the lower bottom surface of the trapezoidal block 253, so that when the rotating block 251 moves toward the lower bottom surface of the trapezoidal block 253, the rotating block 251 will abut against the lower bottom surface of the trapezoidal block 253 and thus rotate it, and similarly, the trapezoidal block 253 will drive the rotating block 251 to rotate, thereby causing The rotating block 251 drives the threaded rod 25 to rotate downward, and when the threaded rod 25 rotates upward, the rotating block 251 rotates in the opposite direction, so that the side surface of the rotating block 251 abuts against the inclined surface of the trapezoidal block 253, and the rotating block 251 abuts against the inclined surface, so that the inclined surface of the trapezoidal block 253 is forced to move toward the inside of the mounting groove and compress the third spring 252. Therefore, at this time, the self-rotation of the threaded rod 25 and the rotating block 251 will not drive the mounting column 15 to rotate. It is more preferred to install magnets that attract each other at the lower end of the solution mixer 16 and the upper end of the container 23, so as to increase the stability of the mounting column 15.

[0038] Example 2:

[0039] Further improvements are made on the basis of Example 1. The solution mixer 16 includes a mixing column 40 installed inside the mounting column 15. The upper end of the mixing column 40 is symmetrically provided with spiral grooves 41. The two spiral grooves 41 rotate in opposite directions. An annular groove 42 communicating with the two spiral grooves 41 is provided in the center of the mixing column 40. The upper end of the mixing column 40 is provided with an air inlet groove 43 communicating with the two spiral grooves 41. The lower end of the mixing column 40 is provided with a liquid outlet groove 44 communicating with the annular groove 42.

[0040] There are three air inlet grooves 43, which are respectively connected to the three connection points of the two spiral grooves 41. There are several liquid outlet grooves 44, which are inclined from the annular groove 42 to the lower center, and the middle parts of the several liquid outlet grooves 44 are connected to each other.

[0041] After entering the spiral groove 41, the two groups of liquid raw materials move in a spiral downward, and the two spiral grooves 41 will intersect during the downward flow, so that the two groups of liquid raw materials collide and mix, and then flow from the channels toward the two spiral grooves 41, and then collide at the next intersection of the two spiral grooves 41, until they flow out of the spiral groove 41 into the inside of the annular groove 42, and then flow out from the liquid outlet groove 44. The centers of several liquid outlet grooves 44 are staggered with each other, so that the mixed solutions entering from different liquid outlet grooves 44 are mixed and collided at the intersection, and then flow out from different liquid outlet grooves 44 into the inside of the container 23, and the air inlet groove 43 is connected to the intersection of the two spiral grooves 41, so that the mixed gas is mixed and collided at the intersection of the two spiral grooves 41, thereby increasing the mixing efficiency of the solution and the mixed gas.

[0042] Example 3:

[0043] Further improvements are made on the basis of Example 1. The one-way air release component includes a one-way exhaust pipe 48 connected to the upper side of the sealing cylinder 26. The lower end of the one-way exhaust pipe 48 is fixedly connected and installed with an air bag 49, and the lower end of the air bag 49 is connected and provided with an air blowing pipe 50. After the cleaning liquid enters the sealing cylinder 26, the interior of the sealing cylinder 26 is in a normal state, so that the cleaning liquid can also flow into the one-way output pipe 30 under the action of gravity. Therefore, when the threaded rod 25 drives the piston 29 to move upward, the air inside the sealing cylinder 26 will move to the one-way exhaust pipe 48 until the piston 29 returns to its initial state and the air will enter the air bag 49 from the one-way output pipe 30 and be stored, causing the air bag 49 to expand and unable to re-enter the sealing cylinder 26 from the one-way exhaust pipe 48. When the mounting column 15 rotates, the solution mixer 16 will be aligned with the air blowing pipe 50, so that the gas inside the air bag 49 is blown from the air blowing pipe 50 to the solution mixer 16, thereby blowing off the water stains inside the solution mixer 16.

[0044] The waste collection assembly includes two waste pipes 51, one of which is matched with the one-way air release assembly, and the other waste pipe 51 is symmetrically arranged with the container 23. A waste box 52 is installed on the lower side of the installation box body 1, and the two waste pipes 51 are connected to the waste box 52 through a connecting pipe; in this way, the waste when the cleaning liquid of the solution mixer 16 flows through and when the air pipe 50 is blown can be discharged into the waste pipe 51 and then stored in the waste box 52.

[0045] Example 3:

[0046] On the basis of Example 1, further improvements are made. The upper end of the storage bag 60 is fixedly connected to a feed pipe 61, a sliding groove is provided inside the feed pipe 61, a ring plate 62 is slidably connected inside the sliding groove, a second spring 63 is fixedly installed on the upper end of the ring plate 62, a threaded cylinder 64 threadedly connected to the cylinder 19 is slidably connected inside the sliding groove, a slider 65 matching the limit groove is fixedly connected to the upper end of the feed pipe 61, a liquid outlet pipe 66 is provided at the lower end of the storage bag 60, and a sealing cover 67 is threadedly connected to the threaded cylinder 64; in the initial state, the ring plate 62 abuts against the bottom of the sliding groove. At this time, the second spring 63 is in a natural state. When the container 23 is connected to the cylinder 19, the slider 65 is aligned with the limit groove and then moves upward, which will cause the feed pipe 61 to drive the limiting assembly and the outer gear ring 22 to move upward until the threaded cylinder 64 is threadedly connected to the cylinder 19. Since the elastic force of the first spring 20 is greater than the elastic force of the second spring 63, the rebound force of the first spring 20 will drive the feed pipe 61 to slide downward on the outside of the threaded cylinder 64, thereby restoring the outer gear ring 22 to its initial state.

[0047] The above embodiments are merely illustrative of the principles and effects of the present invention and are not intended to limit the present invention. Anyone skilled in the art may modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by one of ordinary skill in the art without departing from the spirit and technical principles disclosed herein are intended to be covered by the claims of the present invention.

Claims

1. An artificial cerebrospinal fluid proportioning device, comprising a mounting box and a mixed gas supply device, characterized in that: Two raw material storage boxes are installed inside the installation box, and discharge pipes are installed at the lower ends of the two raw material storage boxes. The mixed gas supply device is installed outside the installation box, and an outlet pipe is installed at the output end of the mixed gas supply device. The lower end of the installation box is rotatably connected to a mounting column, and a solution mixer is symmetrically installed inside the installation column. An inlet matching two discharge pipes and one outlet pipe is opened at the upper end of the solution mixer, and a protective cylinder located outside the installation column is installed at the lower end of the installation box. A circular plate is fixedly connected to the inside of the protective cylinder through a connecting rod, and the circular plate is fixedly connected to a cylinder matching the solution mixer. A first spring is fixedly installed at the lower end of the circular plate, and an abutment ring is fixedly installed at the lower end of the first spring; The outer surface of the cylinder is provided with an external gear ring, and the cylinder is threadedly connected to a container matching the solution mixer, and the outer side of the mounting post is fixedly connected to a gear ring cylinder meshing with the outer gear ring, and a limiting assembly is provided between the outer gear ring and the protective cylinder, and the limiting assembly is provided with a limiting groove matching the container, and the middle of the mounting post is connected to a threaded rod for sliding up and down, and a one-way rotation assembly is provided between the threaded rod and the mounting post, and the interior of the mounting box is fixedly connected to a sealing cylinder threadedly connected to the threaded rod, and a torsion spring box is installed on the upper side of the sealing cylinder, and the output end of the torsion spring box is fixedly connected to a rotating rod connected to the threaded rod for sliding up and down, the upper end of the threaded rod is fixedly connected to a piston that is sealingly and slidingly connected to the rotating rod and the sealing cylinder, and the lower end of the piston is connected to a one-way output pipe connected to the solution mixer, a cleaning liquid storage tank is installed inside the mounting box, and the upper side of the sealing cylinder is connected to a one-way inlet pipe connected to the cleaning liquid storage tank, a one-way air release assembly is installed on the upper side of the sealing cylinder, and the lower end of the protective cylinder is provided with a waste collection assembly; The solution mixer includes a mixing column installed inside the mounting column, wherein the upper end of the mixing column is symmetrically provided with spiral grooves, the two spiral grooves rotating in opposite directions, an annular groove communicating with the two spiral grooves is provided in the center of the mixing column, an air inlet groove communicating with the two spiral grooves is provided at the upper end of the mixing column, and a liquid outlet groove communicating with the annular groove is provided at the lower end of the mixing column; The limiting assembly includes a ratchet fixedly connected to the lower end of the outer gear ring, a travel groove matching the ratchet is opened on the lower side of the inner part of the protective tube, a pawl is elastically hinged to the bottom side of the inner part of the travel groove through a torsion spring, and the limiting groove is opened at the lower end of the ratchet; The one-way rotation assembly includes a rotation block fixedly connected to the threaded rod, a plurality of mounting slots are opened inside the mounting column, a third spring is installed in a plurality of the mounting slots, and a trapezoidal block fixedly connected to the third spring is slidably connected in a plurality of the mounting slots; The container includes a storage bag, the upper end of the storage bag is fixedly connected to a feed pipe, a sliding groove is provided inside the feed pipe, a ring plate is slidably connected inside the sliding groove, a second spring is fixedly installed on the upper end of the ring plate, a threaded cylinder threadedly connected to the cylinder is slidably connected inside the sliding groove, a slider matching the limiting groove is fixedly connected to the upper end of the feed pipe, a liquid outlet pipe is provided at the lower end of the storage bag, and a sealing cover is threadedly connected to the threaded cylinder.

2. The artificial cerebrospinal fluid mixing device according to claim 1, characterized in that: There are three air inlet grooves, which are respectively connected to the three connection points of the two spiral grooves. There are several liquid outlet grooves, which are inclined from the annular groove to the lower center, and the middle parts of the several liquid outlet grooves are connected to each other.

3. The artificial cerebrospinal fluid mixing device according to claim 1, characterized in that: The one-way air release assembly includes a one-way exhaust pipe connected to the upper side of the sealing cylinder, the lower end of the one-way exhaust pipe is fixedly connected to an air bag, and the lower end of the air bag is connected to a blowing pipe.

4. The artificial cerebrospinal fluid mixing device according to claim 3, characterized in that: The waste collection assembly includes two waste pipes, one of which matches the one-way air release assembly, and the other waste pipe is symmetrically arranged with the container. A waste box is installed on the lower side of the installation box body, and the two waste pipes are connected to the waste box through a connecting pipe.

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