A Chinese medicine composition for treating chronic atrophic gastritis

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials: 15-25 parts of astragalus, 6-10 parts of coptis root, 10-14 parts of ganoderma lucidum, 6-10 parts of kelp seeds, 15-25 parts of safflower seed, 10-14 parts of curcuma, 6-10 parts of notoginseng, 6-10 parts of processed arisaema, 10-14 parts of raw oyster, 6-10 parts of fructus aurantii and 4-8 parts of liquorice. The syndrome type of chronic atrophic gastritis is spleen and stomach damp-heat type. The invention also discloses a preparation method and application of the traditional Chinese medicine composition.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating chronic atrophic gastritis, and a preparation method and application thereof. Background Art

[0002] Chronic atrophic gastritis (CAG) is a chronic inflammatory pathological process in which the main pathological changes are atrophy, decrease in number, thickening of the muscularis membrane, and thinning of the mucosal layer of the gastric mucosa caused by various causes. The clinical manifestations of this disease are complex and varied, with a lingering course and repeated procrastination. Most patients may experience symptoms such as burning pain, dull pain or fullness, distension, loss of appetite, heating, nausea and vomiting, constipation or diarrhea in the upper abdomen. Severe cases are accompanied by weight loss, anemia, glossitis, brittle nails or atrophy of the tongue papillae. This disease has no obvious specific signs, and there may be mild tenderness in the upper abdomen. The diagnosis and treatment of CAG with intestinal metaplasia and dysplasia has always been a hot topic in the medical community. Foreign literature reports that the incidence of gastric cancer in chronic atrophic gastritis (CAG), especially those with intestinal metaplasia / or dysplasia, can be as high as 9-10%. It is reported that the detection rate of CAG by gastroscopy in my country is about 7.5% to 13.8%, and the incidence rate is high. It has become a common clinical disease of the digestive system. As people age, it is a very common digestive system disease among the middle-aged and elderly. Therefore, early identification and control of the development of CAG into gastric cancer is an important way and effective means to prevent and treat gastric cancer.

[0003] At present, scholars at home and abroad have mainly discussed the etiology and pathogenesis of chronic atrophic gastritis from the aspects of Helicobacter pylori infection, diet and environmental factors, autoimmunity, and other factors. The exact prevalence of this disease is still unclear. Western medicine mainly treats HP, protects and promotes the repair of gastric mucosa, and treats symptoms. There is no specific treatment at present. It is often only symptomatic treatment and cause treatment, which takes a long time to treat, relieves symptoms slowly, has great side effects, and is protracted. There is no effective treatment for CAG and PLGC. According to the clinical manifestations of CAG, Chinese medicine can be classified into the categories of "stomach pain", "fullness", "noise", etc. Its location is in the stomach and is related to the liver and spleen. Chinese medicine believes that the spleen rises and the stomach descends, the liver qi is dredged, the middle jiao is unblocked, and all diseases are relieved. If one of its functions is damaged, external evil, diet, emotions and other factors will invade the body, causing the middle jiao qi to be blocked, and the spleen and stomach to fail to rise and fall, so the disease will occur. Treatment emphasizes syndrome differentiation and treatment, and individualized treatment. The causes of this disease are mostly spleen and stomach weakness, internal injuries, improper diet, emotional disorders, etc. Its disease location is mainly in the stomach, which is closely related to the liver and spleen. Spleen and stomach weakness, qi deficiency and blood stasis, and damp-heat accumulation are the main pathogenesis of CAG. It is currently believed that gastric cells do not directly change from normal cells to cancer cells. This is an accumulation process from quantitative change to qualitative change. The development sequence of the multi-step cancer process is: chronic gastritis, chronic atrophic gastritis, intestinal metaplasia or hyperplasia of gastric cells, and finally gastric cancer. A large number of studies have confirmed that traditional Chinese medicine has its unique advantages in treating CAG. It can not only improve the symptoms of patients, but also reverse glandular atrophy, and even reverse incomplete intestinal metaplasia and dysplasia, thereby blocking its further development and evolution to gastric cancer. As a chronic disease, chronic atrophic gastritis has the characteristics of a long course of disease and repeated symptoms, which seriously reduces the quality of life of patients.

[0004] Traditional Chinese medicine is an empirical medicine. In the process of clinical diagnosis and treatment, the understanding of the etiology and pathogenesis of CAG is "different people have different opinions" based on experience. Chronic gastritis is usually divided into superficial gastritis and atrophic gastritis. The diagnosis and treatment of chronic gastritis in traditional Chinese medicine include the classification and treatment of chronic atrophic gastritis syndrome. In the clinical treatment of CAG, six symptom types of CAG are liver-stomach disharmony, stomach yin deficiency, spleen deficiency and cold, spleen and stomach, damp heat, phlegm obstruction and blood stasis blocking the gastric collaterals. According to the summary of clinical practice, from the classification and clinical observation, it is found that liver-stomach disharmony type, qi stagnation and blood stasis type and liver-stomach wind-cold type are the most common clinical main symptoms. When gastritis is active or symptomatic, the dosage is adjusted according to the different patient conditions. At present, there is no product with definite efficacy for the treatment of chronic atrophic gastritis of spleen and stomach damp heat type. Summary of the invention

[0005] In view of the defects in the prior art, the present invention proposes a Chinese medicine composition for treating chronic atrophic gastritis of spleen and stomach damp-heat type, as well as a preparation method and application thereof. The present invention is guided by the innovative Chinese medicine theory of "clearing away heat and removing dampness, strengthening the spleen and harmonizing the stomach" combined with the theory of "removing depression and removing phlegm, removing blood and removing blood stasis, removing turbidity and softening hard masses", and clinical trial results prove that the Chinese medicine composition has a clear therapeutic effect on chronic atrophic gastritis of spleen and stomach damp-heat type.

[0006] A traditional Chinese medicine composition for treating chronic atrophic gastritis is prepared from the following traditional Chinese medicine raw materials: 15-25 parts of astragalus, 6-10 parts of coptis root, 10-14 parts of ganoderma lucidum, 6-10 parts of kelp seeds, 15-25 parts of safflower seed, 10-14 parts of zedoaria, 6-10 parts of panax notoginseng, 6-10 parts of processed arisaema, 10-14 parts of raw oyster, 6-10 parts of fructus aurantii and 4-8 parts of liquorice.

[0007] The Chinese medicine composition for treating chronic atrophic gastritis is prepared from the following Chinese medicinal materials: 15 parts of astragalus, 10 parts of coptis, 10 parts of ganoderma, 10 parts of kelp seeds, 15 parts of safflower, 14 parts of curcuma, 6 parts of notoginseng, 10 parts of processed arisaema, 10 parts of raw oyster, 10 parts of fructus aurantii, and 4 parts of liquorice.

[0008] The Chinese medicine composition for treating chronic atrophic gastritis is prepared from the following Chinese medicinal materials: 25 parts of astragalus, 6 parts of coptis, 14 parts of ganoderma lucidum, 6 parts of kelp seeds, 25 parts of safflower, 10 parts of curcuma, 10 parts of notoginseng, 6 parts of processed arisaema, 14 parts of raw oyster, 6 parts of fructus aurantii, and 8 parts of liquorice.

[0009] The Chinese medicine composition for treating chronic atrophic gastritis is prepared from the following Chinese medicinal materials: 20 parts of astragalus, 8 parts of coptis, 12 parts of ganoderma, 8 parts of kelp seeds, 20 parts of safflower, 12 parts of curcuma, 8 parts of notoginseng, 8 parts of processed arisaema, 12 parts of raw oyster, 8 parts of fructus aurantii, and 6 parts of liquorice.

[0010] The preparation method of the Chinese medicine composition for treating chronic atrophic gastritis comprises the following steps: taking each Chinese medicine raw material according to weight proportion, adding water and boiling twice, the first time for 2 hours and the second time for 1 hour, combining the decoctions, filtering, adding auxiliary materials, and preparing a liquid preparation.

[0011] The preparation method of the Chinese medicine composition for treating chronic atrophic gastritis comprises the following steps: taking each Chinese medicinal material raw material according to weight proportion, adding water and decocting twice, the first time for 2 hours and the second time for 1 hour, combining the decoctions, filtering, concentrating the filtrate to a thick paste with a relative density of 1.30-1.35, spray drying, adding auxiliary materials, and preparing a solid preparation.

[0012] The Chinese medicine composition for treating chronic atrophic gastritis comprises one or more of sodium starch glycolate, sodium carboxymethyl cellulose, calcium carboxymethyl cellulose, cross-linked sodium carboxymethyl cellulose, cross-linked polyvinylpyrrolidone, chitosan, agar, alginic acid, calcium alginate, methyl cellulose, powdered cellulose, low-alkyl-substituted hydroxypropyl cellulose, hydroxypropyl starch, low-substituted hydroxypropyl cellulose, dextrin, pregelatinized starch, rice starch, wheat starch, corn starch, potato starch and sucrose as auxiliary materials.

[0013] The Chinese medicine composition for treating chronic atrophic gastritis is a liquid preparation which is an oral liquid or a mixture.

[0014] The solid preparation of the Chinese medicine composition for treating chronic atrophic gastritis is one of pills, powders, tablets, granules and capsules.

[0015] The Chinese medicine composition for treating chronic atrophic gastritis is of the spleen and stomach damp-heat type.

[0016] Beneficial effects:

[0017] 1. Weak spleen and stomach are the internal cause of chronic atrophic gastritis and the origin of mild atypical hyperplasia of gastric mucosa. Pathological products such as phlegm, dampness, blood stasis and toxins gradually generated by long-term spleen and stomach weakness, namely microscopic accumulation, are the key to the formation of atypical hyperplasia of gastric mucosa. We believe that accumulation is caused by the entanglement of phlegm, qi, and turbidity. Although dysplasia and intestinal metaplasia do not appear abnormal to the naked eye, they have accumulated microscopically, so we believe that they are also caused by the entanglement of phlegm, qi and blood stasis in the stomach. Moreover, in patients with gastric mucosal dysplasia, most of them can be seen under gastroscopy with lesions such as rough mucosa, hyperplasia, congestion, and edema. When the exogenous dampness, improper diet, and frequent consumption of fatty and greasy food, atrophic gastritis of spleen and stomach damp-heat type occurs, with the main symptoms of: discomfort or burning pain in the stomach, noisy belching, bitter and sticky mouth, thirst without desire to drink, or abdominal distension and loose stools, red tongue, thick or greasy yellow fur, stringy or slippery pulse. Modern scientific research shows that dysplasia is a clear epithelial tumor growth, representing the initial stage of tumor growth, indicating the consensus of Chinese and Western medicine on this disease. Therefore, according to the idea of ​​treating cancer, it is treated with "clearing heat and removing dampness, strengthening the spleen and stomach" combined with "removing depression and resolving phlegm, breaking blood and removing blood stasis, and removing turbidity and softening hard masses". In the prescription of the present invention, Astragalus is the "king of qi tonic", especially good at tonic the qi of the middle jiao; Coptis chinensis is bitter and cold, belongs to the spleen and stomach meridian, especially good at clearing away dampness and heat in the middle jiao, aiming to clear away heat and dampness, and its pharmacological effects show that it also has the effects of anti-HP, anti-gastric ulcer, and protection of gastric mucosa; the two medicines are used together to invigorate qi and strengthen the spleen, clear away heat and dampness, and are the main medicine. Long-term spleen deficiency, maternal disease and child, lung qi deficiency, adding Ganoderma lucidum to invigorate qi and nourish the lung, combined with Astragalus, can regulate the body's immunity, improve the body's disease resistance, and promote the recovery of the disease. Asparagus corylifolia, clearing heat and removing dampness, make the dampness and heat in the middle jiao go out through urination, and help Coptis chinensis to remove the evil of dampness and heat in the middle jiao. "Long-term illness enters the collaterals, and long-term illness must be stagnant", with the help of Sargentophyllum sphaerocephalum, Curcuma zedoaria, and Panax notoginseng to promote blood circulation and remove blood stasis, reduce swelling and disperse knots, and the pharmacological effects of these three medicines show that they all have the effects of anti-platelet aggregation, improving microcirculation, promoting the recovery of gastric mucosal blood flow and anti-tumor. The above five medicines are ministerial medicines. CAG patients often have decreased digestive function and food stagnation. Adding Citrus aurantium and Liushenqu can promote qi and relieve fullness, digestion and stomach. Processed Arisaema is pungent and warm, can resolve phlegm, dissipate stagnation and relieve abdominal distension. When used together with Coptis chinensis, it can open up the spleen and stomach in a pungent and bitter way, and restore the qi of the middle jiao spleen and stomach. The D-mannitol crystals contained in it can also inhibit tumor activity. Adding raw oyster can reduce acid and relieve pain, and protect the gastric mucosa. The above four herbs are adjuvants. Raw licorice is sweet and warm in nature. It can help Qi nourish the spleen and harmonize the other herbs. It is a guiding herb. The whole formula is used together to expel evil spirits and consolidate the foundation, and treat both the symptoms and the root causes. It can strengthen the spleen and stomach, clear away heat and dampness, promote blood circulation and remove blood stasis, and reduce swelling and resolve stagnation.

[0018] 2. Clinical results showed that among 60 patients with chronic atrophic gastritis, 32 were clinically cured, 15 were markedly effective, 9 were effective, and 4 were ineffective, with a total efficacy of 93.3%. After treatment, the total score of TCM symptoms decreased compared with that before treatment, with P values ​​less than 0.05, and the differences were statistically significant, indicating that the present invention can effectively improve the clinical symptoms of chronic atrophic gastritis of spleen and stomach damp-heat type. DETAILED DESCRIPTION

[0019] The present invention will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the content of the present invention, those skilled in the art can make various changes or modifications to the present invention, but these equivalent forms fall within the scope limited by the appended claims of the application equally.

[0020] Embodiment 1:

[0021] Take 2000g of astragalus, 800g of coptis, 1200g of ganoderma lucidum, 800g of amaranth, 2000g of spatholobi, 1200g of curcuma, 800g of notoginseng, 800g of processed arisaema, 1200g of raw oyster, 800g of fructus aurantii and 600g of liquorice. The preparation method comprises the following steps: taking each Chinese medicinal material according to weight proportion, adding water and decocting twice, the first time for 2 hours and the second time for 1 hour, combining the decoctions, filtering, concentrating the filtrate to a thick paste with a relative density of 1.30-1.35, spray drying, adding appropriate amount of corn starch to make granules.

[0022] Embodiment 2:

[0023] Take 1500g of astragalus, 1000g of coptis, 1000g of ganoderma lucidum, 1000g of amaranth, 1500g of safflower, 1400g of curcuma, 600g of panax notoginseng, 1000g of processed arisaema, 1000g of raw oyster, 1000g of fructus aurantii and 400g of liquorice. The preparation method comprises the following steps: taking each Chinese medicinal material according to weight proportion, adding water and decocting twice, the first time for 2 hours and the second time for 1 hour, combining the decoctions, filtering, concentrating the filtrate to a thick paste with a relative density of 1.30-1.35, spray drying, adding appropriate amount of methyl cellulose, and making tablets.

[0024] Embodiment 3:

[0025] Take 2500g of astragalus, 600g of coptis, 1400g of ganoderma lucidum, 600g of amaranth, 2500g of safflower, 1000g of curcuma, 1000g of panax notoginseng, 600g of processed arisaema, 1400g of raw oyster, 600g of fructus aurantii and 800g of liquorice. The preparation method comprises the following steps: taking each Chinese medicinal material according to weight proportion, adding water and decocting twice, the first time for 2 hours and the second time for 1 hour, combining the decoctions, filtering, concentrating the filtrate to a thick paste with a relative density of 1.30-1.35, spray drying, adding appropriate amount of sodium carboxymethyl cellulose, and making capsules.

[0026] Embodiment 4:

[0027] Take 2000g of Astragalus, 800g of Coptis chinensis, 1200g of Ganoderma lucidum, 800g of Achyranthes bidentata, 2000g of Sargentodoxae, 1200g of Curcuma, 800g of Notoginseng, 800g of processed Arisaema, 1200g of raw oyster, 800g of Citrus aurantium, and 600g of Licorice. The preparation method comprises the following steps: taking each Chinese medicinal material according to weight proportion, adding water and decocting twice, the first time for 2 hours and the second time for 1 hour, combining the decoctions, filtering, adding sucrose, and making an oral solution.

[0028] Embodiment 5:

[0029] Take 2000g of Astragalus, 800g of Coptis chinensis, 1200g of Ganoderma lucidum, 800g of Achyranthes bidentata, 2000g of Sargentodoxae, 1200g of Curcuma, 800g of Notoginseng, 800g of processed Arisaema, 1200g of raw oyster, 800g of Citrus aurantium, and 600g of Licorice. The preparation method comprises the following steps: take each Chinese medicinal material according to weight proportion, add water and boil twice, the first time for 2 hours and the second time for 1 hour, combine the decoctions, filter, add sucrose, and make a mixture.

[0030] Example 6: Clinical Experimental Study of the Present Invention

[0031] 1. Materials and methods

[0032] 1.1 General Information

[0033] Case source: 60 patients with chronic atrophic gastritis of spleen and stomach damp-heat type were selected from the outpatient medical record system of the Department of Gastroenterology of Jiangsu Provincial Hospital of Integrated Traditional Chinese and Western Medicine. Symptoms: discomfort or burning pain in the stomach, noisy belching, bitter and sticky mouth, thirst without desire to drink, or abdominal distension and loose stools, red tongue, thick or greasy yellow fur, and stringy or slippery pulse. The time was from September 2021 to February 2023. The patients were aged 30-79 years old, with an average of (56.3±5.8) years old, and half were male and half were female. There was no statistical difference in gender and age between the two groups (P>0.05).

[0034] 1.2 Treatment

[0035] The granules prepared in Example 1 were used, and the daily dosage per person was 20g of Astragalus, 8g of Coptis, 12g of Ganoderma Lucidum, 8g of Achyranthes, 20g of Sargentodoxae, 12g of Curcuma, 8g of Notoginseng, 8g of Arisaema, 12g of Oyster, 8g of Citrus Aurantium, and 6g of Licorice. The course of treatment was 4 weeks, during which other drugs for treating stomach-related diseases were discontinued, and a light diet was adopted, avoiding spicy, cold, greasy and other foods.

[0036] 1.3 Observation indicators

[0037] Adverse reactions, changes in the total score of TCM symptoms before and after treatment, and the overall efficacy were observed (see Table 1 for the quantitative scoring table of TCM symptoms). TCM syndrome efficacy evaluation: The efficacy evaluation standard was formulated according to the "Guidelines for Clinical Research of New Chinese Medicines", and the nimodipine method was used for calculation: efficacy index = [(pre-treatment score - post-treatment score) / pre-treatment score] × 100%. ① Clinical cure: the main symptoms and signs disappeared or basically disappeared, and the efficacy index was ≥ 95%; ② Significant effect: the main symptoms and signs were significantly improved, 70% ≤ efficacy index < 95%; ③ Effective: the main symptoms and signs were significantly improved, 30% ≤ efficacy index < 70%; ④ Ineffective: the main symptoms and signs were not significantly improved, or even aggravated, and the efficacy index was < 30%.

[0038] Table 1 Quantitative scoring table for TCM symptoms

[0039]

[0040] 1.4 Statistical analysis

[0041] The quantitative data were expressed as (X±S) and the t test was used; the enumeration data were expressed as percentage (%) and the chi-square test was used. P<0.05 indicated that the difference was statistically significant.

[0042] 2. Results

[0043] 2.1 Overall efficacy

[0044] The overall efficacy was 93%, as shown in Table 2.

[0045] Table 2 Effectiveness of patients

[0046] Number of cases invalid efficient Significant effect get well Total effective rate% 60 4 9 15 32 93.3

[0047] 2.2 TCM symptom score

[0048] After treatment, the total score of TCM symptoms decreased compared with that before treatment, and P was less than 0.05, and the differences were statistically significant, indicating that the present invention can effectively improve the clinical symptoms of chronic atrophic gastritis of spleen and stomach damp-heat type. See Table 3 for details.

[0049] Table 3 Changes in the total score of TCM symptoms before and after treatment

[0050]

[0051] 2.3 Safety Observation

[0052] No adverse reactions occurred.

[0053] 3. Conclusion

[0054] The present invention has a definite therapeutic effect in treating chronic atrophic gastritis of the spleen and stomach damp-heat type, and can significantly improve the clinical symptoms of patients with chronic atrophic gastritis of the spleen and stomach damp-heat type.

[0055] 4. Typical Cases

[0056] 4.1 Cai, male, 48 years old, came to the hospital for treatment in May 2019 and was diagnosed with chronic atrophic gastritis of spleen and stomach damp-heat type. Symptoms: stomach discomfort, noisy belching, bitter and sticky mouth, thirst without desire to drink, abdominal distension and loose stools, red tongue, thick yellow fur, and stringy pulse. After taking 20g of Astragalus, 8g of Coptis chinensis, 12g of Ganoderma lucidum, 8g of Asparagus cochinchinensis, 20g of Sarcandra chinensis, 12g of Curcuma zedoaria, 8g of Panax notoginseng, 8g of processed Arisaema, 12g of Raw Oyster, 8g of Citrus aurantium, and 6g of Licorice (daily dosage) for three months, the symptoms were significantly improved, and there was no recurrence during the six-month follow-up.

[0057] 4.2 Chen, female, 65 years old, came to the hospital for treatment in August 2020 and was diagnosed with chronic atrophic gastritis of spleen and stomach damp-heat type. Symptoms: constant burning pain in the stomach, noisy belching, bitter and sticky mouth, thirst without desire to drink, abdominal distension and loose stools, red tongue, yellow and greasy fur, and slippery and rapid pulse. After taking 20g of Astragalus, 8g of Coptis chinensis, 12g of Ganoderma lucidum, 8g of Asparagus cochinchinensis, 20g of Sarcandra chinensis, 12g of Curcuma zedoaria, 8g of Panax notoginseng, 8g of processed Arisaema, 12g of Raw Oyster, 8g of Citrus aurantium, and 6g of Licorice (daily dosage) for four months, the symptoms were significantly alleviated, and there was no recurrence during the six-month follow-up.

[0058] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for treating chronic atrophic gastritis, characterized in that: The Chinese medicine composition is prepared from the following Chinese medicinal materials: 15-25 parts of astragalus, 6-10 parts of coptis, 10-14 parts of ganoderma, 6-10 parts of kelp seeds, 15-25 parts of safflower, 10-14 parts of zedoaria, 6-10 parts of panax notoginseng, 6-10 parts of processed arisaema, 10-14 parts of raw oyster, 6-10 parts of fructus aurantii and 4-8 parts of liquorice.

2. The Chinese medicine composition for treating chronic atrophic gastritis according to claim 1, characterized in that: The Chinese medicine composition is prepared from the following Chinese medicinal materials: 15 parts of astragalus, 10 parts of coptis, 10 parts of ganoderma, 10 parts of kelp seeds, 15 parts of safflower, 14 parts of curcuma, 6 parts of notoginseng, 10 parts of processed arisaema, 10 parts of raw oyster, 10 parts of fructus aurantii and 4 parts of liquorice.

3. The Chinese medicine composition for treating chronic atrophic gastritis according to claim 1, characterized in that: The Chinese medicine composition is prepared from the following Chinese medicinal materials: 25 parts of astragalus, 6 parts of coptis, 14 parts of ganoderma lucidum, 6 parts of kelp seeds, 25 parts of safflower, 10 parts of curcuma, 10 parts of notoginseng, 6 parts of processed arisaema, 14 parts of raw oyster, 6 parts of fructus aurantii, and 8 parts of liquorice.

4. The Chinese medicine composition for treating chronic atrophic gastritis according to claim 1, characterized in that: The Chinese medicine composition is prepared from the following Chinese medicinal materials: 20 parts of astragalus, 8 parts of coptis, 12 parts of ganoderma, 8 parts of kelp seeds, 20 parts of safflower, 12 parts of curcuma, 8 parts of notoginseng, 8 parts of processed arisaema, 12 parts of raw oyster, 8 parts of fructus aurantii and 6 parts of liquorice.

5. The Chinese medicine composition for treating chronic atrophic gastritis according to claim 1, characterized in that: The preparation method comprises the following steps: taking each Chinese medicinal material raw material according to weight proportion, adding water and boiling twice, the first time for 2 hours and the second time for 1 hour, combining the decoctions, filtering, adding auxiliary materials, and preparing a liquid preparation.

6. The Chinese medicine composition for treating chronic atrophic gastritis according to claim 1, characterized in that: The preparation method comprises the following steps: taking each Chinese medicinal material raw material according to weight proportion, adding water and decocting twice, the first time for 2 hours and the second time for 1 hour, combining the decoctions, filtering, concentrating the filtrate to a thick paste with a relative density of 1.30-1.35, spray drying, adding auxiliary materials, and preparing a solid preparation.

7. The Chinese medicine composition for treating chronic atrophic gastritis according to claim 5, characterized in that: Liquid preparations are a type of oral solution or mixture.

8. The Chinese medicine composition for treating chronic atrophic gastritis according to claim 6, characterized in that: The solid preparation is one of pills, powders, tablets, granules and capsules.

9. The Chinese medicine composition for treating chronic atrophic gastritis according to claim 5 or 6, characterized in that: The excipients are one or more of sodium starch glycolate, sodium carboxymethyl cellulose, calcium carboxymethyl cellulose, cross-linked sodium carboxymethyl cellulose, cross-linked polyvinylpyrrolidone, chitosan, agar, alginic acid, calcium alginate, methylcellulose, powdered cellulose, lower alkyl-substituted hydroxypropyl cellulose, hydroxypropyl starch, low-substituted hydroxypropyl cellulose, dextrin, pregelatinized starch, rice starch, wheat starch, corn starch, potato starch, and sucrose.

10. The Chinese medicine composition for treating chronic atrophic gastritis according to claim 1, characterized in that: The syndrome type of chronic atrophic gastritis is spleen and stomach damp-heat type.

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