A composition containing fluorine-containing chrysanthemic acid diester or KII-9396 and use thereof

Abstract

The present application relates to the composition containing the biologically effective amount of compound I and fluensulfamide or KII-9396, and the method for preventing and treating pests in agronomic and non-agronomic environment. The compound I has synergistic effect with fluensulfamide or KII-9396, can improve the pest control effect, reduce the application amount, reduce the use frequency, and reduce the use cost.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of pesticide combination, and relates to a composition containing a biologically effective amount of compound I and fluensulfamide or KII-9396, and a method thereof for controlling pests in agronomic and non-agronomic environments. BACKGROUND

[0002] In recent years, the occurrence of various crop pests shows a trend of increasing year by year, and the occurrence area increases year by year, which brings great harm to crops, thereby causing problems such as crop yield reduction and agricultural production cost increase. In order to improve the control effect on pests, farmers increase the amount of pesticide or randomly mix pesticides. Such unscientific use of pesticides not only fails to achieve the synergistic effect, but also leads to problems such as waste of pesticides, excessive pesticide residues, pollution of the environment, and resistance of pests to pesticides. Therefore, it is urgent to develop a synergistic composition for pests, which can achieve the effects of expanding the range of control objects, reducing the amount of pesticide, and delaying the generation of resistance.

[0003] In the actual process of agricultural production, long-term continuous use of the same pesticide will quickly lead to pesticide resistance of pests, resulting in reduced control effect and increased pesticide use, which aggravates the damage to the ecological environment and the pesticide residues in agricultural products. By compounding with insecticides of completely different action mechanisms, the pesticide resistance of pests is delayed, the insecticidal spectrum is expanded, the service life is prolonged, and the amount of pesticide used is reduced. However, how to compound the pesticides to produce synergistic rather than antagonistic effects between the pesticides is a difficult problem.

[0004] Patent document CN 111909143 A discloses compound I, which has broad-spectrum insecticidal activity, especially good control effect on pests such as Lepidoptera, Hemiptera, Coleoptera, Thysanoptera, Diptera, and mites. However, how to compound it with other pesticides to achieve the purpose of synergism is not disclosed.

[0005] The structural formula of compound I is as follows,

[0006] SUMMARY

[0007] In order to improve the deficiencies of the prior art, the present application first provides a composition containing compound I and compound II, wherein the compound II is fluensulfamide, KII-9396 or a combination thereof,

[0008] The structural formula of compound I is as follows,

[0009]

[0010] The KII-9396 is (RS)-[5-[4-chloro-2-fluoro-5-[(2,2,2-trifluoroethyl)sulfinyl]phenoxy]pentyl] trifluoromethylsulfide (CAS: 1472050-04-6).

[0011] According to an embodiment of the present application, the compound I is prepared by the method of Example 1 in the patent document CN 111909143 A, the whole of which is incorporated herein by reference.

[0012] According to an embodiment of the present application, the mass ratio of the compound I and the compound II is 80-1:1-80, preferably the mass ratio is 50-1:1-50, more preferably the mass ratio is 10-1:1-10, for example 50:1, 40:1, 30:1, 20:1, 10:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:10, 1:20, 1:30, 1:40 or 1:50.

[0013] According to an embodiment of the present application, the composition can be prepared into a liquid preparation or a solid preparation.

[0014] According to an embodiment of the present application, the content of the effective active ingredient in the preparation varies according to different preparation types, generally, the liquid preparation contains 1-60% of the effective active ingredient by weight, preferably 5-50%; the solid preparation contains 5-80% of the effective active ingredient by weight, preferably 10-70%.

[0015] According to an embodiment of the present application, the composition further comprises at least one of deionized water, an organic solvent, an emulsifier, a dispersant, a wetting agent, a thickening agent, an antifoaming agent, a stabilizer, a binder, a disintegrant, an antifreezing agent, an anticaking agent, a suspending agent, a film-forming agent, a preservative, a coloring agent, a high molecular capsule wall material, a pH adjuster or a filler.

[0016] According to an embodiment of the present application, the total mass of the compound I and the compound II in the composition is 1-80%, preferably 2-70%, or 5-65%; 10-60%, for example 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45% or 50%, based on the total weight of the composition being 100%.

[0017] According to the embodiments of the present application, the composition can be diluted by the user before use or used directly. Its formulation can be prepared by the processing method known to those skilled in the art, i.e. mixing the effective active ingredients (i.e. Compound I and Compound II) with one or more of deionized water, organic solvents, emulsifiers, dispersants, wetting agents, thickeners, antifoaming agents, stabilizers, binders, disintegrants, anti-freezing agents, anti-caking agents, suspending agents, film-forming agents, preservatives, colorants, high molecular capsule wall materials, pH regulators or fillers, etc. to obtain the composition.

[0018] According to the embodiments of the present application, the composition can be prepared into various dosage forms, preferably, the dosage forms include wettable powder, water dispersible granule, suspension, aqueous emulsion, suspension seed coating, microcapsule suspension, microcapsule suspension-suspension, emulsifiable concentrate, microemulsion, dispersible liquid, or granule.

[0019] According to the embodiments of the present application, when the composition is prepared into wettable powder, it comprises the following components and contents: Compound I 1%~80%, Compound II 1%~80%, dispersant 0%~10%, wetting agent 0%~8%, and the rest is filler.

[0020] Preferably, Compound I in the composition is 2%~70%, 5%~65%, 10%~60%, 15%~50%, etc.

[0021] Compound II is 2%~70%, 5%~65%, 10%~60%, 15%~50%, etc.

[0022] The dispersant is 1%~8%, 2%~7%, 3-6% or 4%~5%.

[0023] The wetting agent is 1%~8%, 2%~7%, 3-6% or 4%~5%. According to the embodiments of the present application, when the composition is prepared into water dispersible granule, it comprises the following components and contents: Compound I 1%~80%, Compound II 1%~80%, dispersant 0%~10%, wetting agent 0%~16%, disintegrant 0%~20%, and the rest is filler.

[0024] Preferably, Compound I in the composition is 2%~70%, 5%~65%, 10%~60%, 15%~50%, etc.

[0025] Compound II is 2%~70%, 5%~65%, 10%~60%, 15%~50%, etc.

[0026] The dispersant is 1%~8%, 2%~7%, 3-6% or 4%~5%.

[0027] The wetting agent is 1%~8%, 2%~7%, 3-6% or 4%~5%.

[0028] Disintegrants are 1-18%, 2-16%, 3-15%, 4-12%, 5-10% or 6-8%.

[0029] According to an embodiment of the present application, the composition when formulated as a flowable concentrate includes the following components and amounts: Compound I 1-50%, Compound II 1-50%, dispersing agent 0-5%, wetting agent 0-8%, thickening agent 0-0.3%, anti-freeze agent 0-5%, and the balance deionized water.

[0030] Preferably, Compound I in the composition is 2-45%, 5-40%, 10-35%, 15-30%, 20-25%, etc.

[0031] Compound II is 2-45%, 5-40%, 10-35%, 15-30%; 20-25%, etc.

[0032] The dispersing agent is 1-4% or 2-3%.

[0033] The wetting agent is 1-8%, 2-7%, 3-6% or 4-5%.

[0034] The thickening agent is 0.1-0.25%.

[0035] The anti-freeze agent is 1-4% or 2-3%. According to an embodiment of the present application, the composition when formulated as an emulsifiable concentrate includes the following components and amounts: Compound I 1-50%, Compound II 1-50%, organic solvent 0-95%, emulsifying agent 0-10%, anti-freeze agent 0-5%, anti-foaming agent 0-0.2%, thickening agent 0-0.5%, and the balance deionized water.

[0036] Preferably, Compound I in the composition is 2-45%, 5-40%, 10-35%, 15-30%, 20-25%, etc.

[0037] Compound II is 2-45%, 5-40%, 10-35%, 15-30%; 20-25%, etc.

[0038] The organic solvent is 1-90%, 2-80%, 5-70%, 10-60%, 15-50%; 20-50%, 30-40%, etc.

[0039] The emulsifying agent is 1-8%, 2-7%, 3-6% or 4-5%.

[0040] The anti-freeze agent is 1-4% or 2-3%.

[0041] Antifoam 0.05% to 0.1%, or

[0042] Thickening agent is 0.1% to 0.4%, 0.2% to 0.3%. According to the embodiments of the present application, the composition made into a suspension seed coating includes the following components and contents: Compound I 1% to 50%, Compound II 1% to 50%, dispersing agent 1% to 12%, wetting agent 1% to 10%, anti-freezing agent 1 to 10%, anti-blocking agent 0.1 to 10%, suspending agent 0.1 to 5%, film forming agent 1 to 10%, preservative 0.1 to 5%, colorant 1 to 30%, pH regulator 0.1% to 5%, thickening agent 0.1% to 8%, and the balance is deionized water.

[0043] Preferably, Compound I in the composition is 2% to 45%, 5% to 40%, 10% to 35%, 15% to 30%, 20% to 25%, etc.;

[0044] Compound II is 2% to 45%, 5% to 40%, 10% to 35%, 15% to 30%; 20% to 25%, etc.;

[0045] The dispersing agent is 2% to 10%, 3% to 8%, 4% to 7%, or 5% to 6%;

[0046] The wetting agent is 1% to 8%, 2% to 7%, 3-6% or 4% to 5%;

[0047] The anti-freezing agent is 1% to 8%, 2% to 7%, 3-6% or 4% to 5%;

[0048] The anti-blocking agent is 0.5% to 9%, 1% to 8%, 2% to 7%, 3-6% or 4% to 5%;

[0049] The suspending agent is 0.2 to 4%, 0.5% to 3.5%, 1% to 3%, 1.5% to 2.5%, or 1.8% to 2%;

[0050] The film forming agent is 2% to 9%, 3% to 8%, 4% to 7%, or 5% to 6%;

[0051] The preservative is 0.2 to 4%, 0.5% to 3.5%, 1% to 3%, 1.5% to 2.5%, or 1.8% to 2%;

[0052] The colorant is 2 to 25%, 3% to 20%, 5% to 15%, 8% to 12%, or 9% to 10%;

[0053] The pH regulator is 0.1% to 5%, 0.2 to 4%, 0.5% to 3.5%, 1% to 3%, 1.5% to 2.5%, or 1.8% to 2%;

[0054] The thickening agent is 0.2% to 7%, 0.5% to 6%, 1% to 5%, 1.5% to 4%, or 2% to 3%.

[0055] According to an embodiment of the present application, the composition, when made into a microcapsule suspension, comprises the following components and amounts: Compound I 1% to 50%, Compound II 1% to 50%, high molecular capsule wall material 1 to 30%, dispersing agent 2% to 10%, organic solvent 1 to 50%, emulsifier 1% to 7%, pH adjuster 0.1% to 5%, antifoaming agent 0.01% to 2%, thickening agent 0.1% to 8%, antifreezing agent 0.1% to 8%, and the balance is deionized water.

[0056] Preferably, Compound I in the composition is 2% to 45%, 5% to 40%, 10% to 35%, 15% to 30%, 20% to 25%, etc.

[0057] Compound II is 2% to 45%, 5% to 40%, 10% to 35%, 15% to 30%, 20% to 25%, etc.

[0058] The high molecular capsule wall material is 2% to 25%, 5% to 20%, 6% to 18%, or 10% to 15%, etc.

[0059] The dispersing agent is 3% to 8%, 4% to 7%, or 5% to 6%.

[0060] The organic solvent is 2% to 45%, 5% to 40%, 10% to 35%, 15% to 30%, or 20% to 25%, etc.

[0061] The emulsifier is 2% to 6% or 4% to 5%.

[0062] The pH adjuster is 0.2% to 4%, 0.5% to 3.5%, 1% to 3%, 1.5% to 2.5%, or 1.8% to 2%.

[0063] The antifoaming agent is 0.05% to 1.8%, 0.1% to 1.5%, 0.5% to 1.3%, or 0.8% to 1.0%.

[0064] The thickening agent is 0.2% to 7%, 0.5% to 6%, 1% to 5%, 1.5% to 4%, or 2% to 3%.

[0065] The antifreezing agent is 0.5% to 7%, 1% to 6%, 2% to 5%, or 3% to 4%.

[0066] According to the embodiment of the present application, the composition is made into a microcapsule suspension-suspension agent, and comprises the following components and contents: compound I 1% to 50%, compound II 1% to 50%, high molecular capsule wall material 1% to 12%, dispersant 1% to 12%, wetting agent 1% to 8%, organic solvent 1 to 50%, emulsifier 1% to 8%, antifoaming agent 0.01% to 2%, thickening agent 0.1% to 8%, pH regulator 0.1% to 5%, anti-freezing agent 0.1% to 8%, and the rest is deionized water.

[0067] According to the embodiment of the present application, the composition is made into an emulsifiable concentrate, and comprises the following components and contents: compound I 1% to 50%, compound II 1% to 50%, emulsifier 0 to 10%, anti-freezing agent 0% to 5%, stabilizer 0% to 0.5%, and the rest is organic solvent.

[0068] Alternatively, compound I 1% to 50%, compound II 1% to 50%, emulsifier 0 to 12%, stabilizer 0% to 0.5%, and the rest is organic solvent.

[0069] According to the embodiment of the present application, the composition is made into a microemulsion, and comprises the following components and contents: compound I 1% to 50%, compound II 1% to 50%, organic solvent 1 to 50%, emulsifier 1 to 30%, anti-freezing agent 1% to 10%, stabilizer 0.1% to 5%, and the rest is deionized water.

[0070] According to the embodiment of the present application, the composition is made into a dispersible liquid, and comprises the following components and contents: compound I 1% to 50%, compound II 1% to 50%, emulsifier 1 to 30%, anti-freezing agent 1% to 10%, stabilizer 0.1% to 5%, and the rest is organic solvent.

[0071] According to the embodiment of the present application, the composition is made into a granule, and comprises the following components and contents: compound I 0.1% to 10%, compound II 0.1% to 10%, dispersant 0% to 5%, wetting agent 0% to 5%, binder 0% to 3%, and the rest is filler.

[0072] According to the embodiment of the present application, the emulsifier can be selected from at least one of the following: sodium lignosulfonate, agricultural emulsifier, phenyl phenol polyoxyethyl ether phosphate, triphenyl styryl phenol polyoxyethylene ether phosphate triethanolamine salt, benzyl dimethyl phenol polyoxyethyl ether, sorbitan fatty acid ester polyoxyethylene ether, sorbitan oleate (Span-80), fatty alcohol polyoxyethylene ether, sodium alkyl naphthalene sulfonate, isooctanol succinate sodium sulfonate, nonyl phenol polyoxyethylene ether phosphate, and castor oil polyoxyethylene ether phosphate.

[0073] According to an embodiment of the present application, the dispersing agent can be selected from at least one of glycerin fatty acid polyoxyethylene ether, polyoxyethylene alkyl aryl ether, sodium lignin sulfonate, naphthalene sulfonate formaldehyde condensate, fatty alcohol polyoxyethylene ether sulfate, naphthalene sulfonate formaldehyde condensate, sodium naphthalene sulfonate formaldehyde condensate, nonylphenol polyoxyethylene ether, polyoxyethylene lanolin alcohol, alkylphenol polyoxyethylene ether formaldehyde condensate, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, polyoxyethylene sorbitan fatty acid ester, phosphate ester.

[0074] According to an embodiment of the present application, the wetting agent can be selected from at least one of trisiloxane polyoxyethylene ether, sodium N-lauroyl glutamate, sodium dodecyl sulfate, sodium lauroyl sarcosinate, sodium methyl naphthalene sulfonate formaldehyde condensate, castor oil polyoxyethylene ether, triphenyl ethyl phenol polyoxyethylene ether, sodium dodecyl benzene sulfonate, sodium alkyl naphthalene sulfonate, sodium isooctanol succinate sulfonate, polyoxyethylene alkyl aryl ether, fatty alcohol polyether glycerin fatty acid polyoxyethylene ether, fatty alcohol polyoxyethylene ether.

[0075] According to an embodiment of the present application, the binder can be selected from at least one of xanthan gum, starch, urea formaldehyde resin, gelatin, gum arabic, carboxymethyl cellulose, carboxyethyl cellulose, polyvinyl alcohol.

[0076] According to an embodiment of the present application, the disintegrant can be selected from at least one of sodium bicarbonate, ammonium sulfate, sodium sulfate, calcium sulfate, magnesium chloride.

[0077] According to an embodiment of the present application, the thickening agent can be selected from at least one of magnesium aluminum silicate, polyvinyl acetate, xanthan gum, gelatin, gum arabic, polyvinyl alcohol.

[0078] According to an embodiment of the present application, the antifoaming agent can be selected from at least one of silicone oil, n-octanol, silicone, butyl phosphate, isobutyl phosphate.

[0079] According to an embodiment of the present application, the antifreeze agent can be selected from at least one of propylene glycol, ethylene glycol, glycerol.

[0080] According to an embodiment of the present application, the stabilizer can be selected from at least one of triethanolamine, epichlorohydrin, butyl glycidyl ether, triphenyl phosphite, N-soybean oil-based triethylene diamine, dialkyl succinate acid sulfonate.

[0081] According to an embodiment of the present application, the filler includes a solid filler and a liquid filler, wherein the solid filler can be selected from at least one of kaolin, attapulgite, diatomite, white carbon, bentonite, montmorillonite, calcium carbonate, talc powder. The liquid filler can be selected from one or more of soybean oil, castor oil, mineral oil.

[0082] According to embodiments of the present application, the organic solvent can be selected from at least one of ethyl acetate, acetone, isopropyl alcohol, 2,2,2-trifluoroethanol, propylene carbonate, benzene, toluene, xylene, dimethylformamide, dimethyl sulfoxide, dichloromethane, cyclohexane, cyclohexanone, N-methyl pyrrolidone, solvent oil (e.g., 150# solvent oil).

[0083] The present application also provides use of the above composition for controlling pests in agriculture or non-agriculture.

[0084] According to embodiments of the present application, the pests are selected from Lepidoptera, Hemiptera, Coleoptera, Thysanoptera, Diptera, mites and the like.

[0085] As an embodiment, the pests are selected from Tetranychus urticae.

[0086] The present application also provides a method for controlling pests in agriculture or non-agriculture, comprising applying the above composition to plants where pests exist.

[0087] The composition of the present application can be provided in the form of a finished formulation, or in the form of a single agent, which is mixed directly before use, and then diluted with water to the desired concentration, and can be applied to crops or plants in any manner, such as spraying, root irrigation, smearing, etc. In specific applications, it can also be mixed with other agents, such as growth regulators, soil conditioners, herbicides, nematicides, etc.

[0088] The present application also provides a composition for controlling invertebrate pests, comprising a biologically effective amount of Compound I, Compound II and at least one other component selected from the group consisting of surfactants, solid diluents and liquid diluents, said composition optionally further containing an effective amount of at least one other biologically active compound or agent, said Compound II being selected from the group consisting of spirodiclofen, KII-9396 or combinations thereof.

[0089] The present application also provides a method for controlling invertebrate pests, comprising contacting said invertebrate pests or their environment with a biologically effective amount of the composition of the present application as described above.

[0090] The present application also provides a spray composition comprising the composition of the present application as described above and a propellant.

[0091] The present application also provides a bait composition comprising the composition of the present application as described above; one or more food materials; optionally an attractant; and optionally a humectant.

[0092] The beneficial effects of the present application are:

[0093] The composition of the present application has the following advantages:

[0094] 1) synergistic effect, can improve the effect of pest control; 2) expand the insecticidal spectrum, mixed occurrence of field insect pests, stronger effect on pests; 3) the mechanism of action of the two active ingredients is different, and the mixed use can delay the development of pest resistance; 4) reduce the amount of application, reduce the use frequency, and reduce the use cost. DETAILED DESCRIPTION

[0095] The technical solutions of the present application will be further described in detail below in combination with specific examples. It should be understood that the following examples are only illustrative and explanatory of the present application, and should not be interpreted as limiting the scope of protection of the present application. Any technology realized based on the above description of the present application is included in the scope intended to be protected by the present application.

[0096] Unless otherwise specified, the raw materials and reagents used in the following examples are commercially available or can be prepared by known methods.

[0097] The compound I used in the following examples was prepared according to the method of Example 1 in the patent document CN 111909143 A.

[0098] The % of each component in the formulations of the following examples, if not specifically stated, refers to the mass percentage content.

[0099] The present application uses the method of combining indoor biological assay and field test to test the insecticidal effect of the composition. It should be pointed out that any modification, equivalent replacement and improvement within the spirit and principles of the present application should be included in the scope of protection of the present application.

[0100] I. Preparation Example of Formulation:

[0101] Preparation Example 1: Wettable powder

[0102]

[0103] The above materials are roughly crushed in proportion and then mixed uniformly in a mixer, and then the finished product is obtained after air flow crushing.

[0104] Preparation Example 2: Water dispersible granule

[0105]

[0106] The active ingredients and various adjuvants are mixed uniformly according to the proportions of the formula, and then the powder is obtained after air flow crushing, and then a certain amount of water is mixed and extruded to form granules, and then the finished product is obtained after drying and screening.

[0107] Preparation Example 3: Suspension concentrate

[0108]

[0109]

[0110] The active ingredient and various adjuvants are mixed uniformly in the proportions of the formula, and after high-speed shearing and sand milling, the finished product is obtained.

[0111] Preparation Example 4: Emulsifiable concentrate

[0112]

[0113] The above raw materials are mixed in the required proportions to dissolve into a uniform oil phase; after passing the inspection, metering and packaging are carried out to obtain the finished product.

[0114] Preparation Example 5: Water emulsion

[0115]

[0116] The above raw materials are added to the batching kettle according to the requirements of the formula, mixed uniformly by high-speed shearing machine to prepare water emulsion, and after passing the inspection, metering and packaging are carried out to obtain the finished product.

[0117] Preparation Example 6: Emulsifiable concentrate

[0118]

[0119]

[0120] The above raw materials are mixed in the required proportions to dissolve into a uniform oil phase; after passing the inspection, metering and packaging are carried out to obtain the finished product.

[0121] Preparation Example 7: Granules

[0122]

[0123] The components are mixed in the required proportions, crushed, wetted with water, and then stirred uniformly, and then granulated by screw extrusion granulator, dried and sieved to obtain the finished product.

[0124] In the above preparation example, compound II is flumite or KII-9396.

[0125] II. Indoor toxicity determination example

[0126] (1) Test insect: Tetranychus urticae Koch.

[0127] (2) Determination method:

[0128] Insect toxicity determination method

[0129] The toxicity of the compounds I, compound II and the mixed preparation thereof was determined by using T. urticae as the test material.

[0130] According to the "Guidelines of Pesticide Indoor Biological Test" (NY / T 1154.12-2008) of the People's Republic of China, the test agent (including compound I and compound II) was prepared into five concentration gradients (according to the LC 50 values of the compounds for different pests, the concentration gradients were set according to the equal ratio or equal difference) with a suitable solvent (the types of the solvent were acetone, methanol, N, N dimethyl formamide and dimethyl sulfoxide, etc., and were selected according to the solubility of the sample). 50 The compound I and compound II for mixing were set into a series of proportions according to the mass ratio according to the LC 50 values, and were prepared into the final mass concentration (referring to the total mass of the compound I and compound II) according to the different proportions.

[0131] The double-sided tape was cut into 2 cm long and was pasted on one end of the glass slide, then healthy female adult mites were selected and were pasted on the back of the double-sided tape (attention should be paid to not paste the mite legs, antennae and mouthparts), 30 mites per piece, were placed in the container with wet sponge, were covered with the cover, and were placed under the condition of (25±1) ℃. After 2 h, the mirror was examined, the dead and injured individuals were removed, and 30 mites per piece were supplemented. After the glass slide was immersed in the drug solution and was shaken gently for 5 s, the excess drug solution was absorbed by the water absorption paper, the glass slide was placed in the white porcelain plate with wet sponge, and the plastic film with good light transmission was covered. Each treatment was repeated 4 times, and the treatment without the drug (containing organic solvent and emulsifier) was set as the blank control.

[0132] The synergistic coefficient (CTC value) of the two drugs in different proportions was calculated according to the method of Sun Yunpei. The synergistic coefficient (CTC) of the mixed agent was greater than or equal to 120, which showed the synergistic effect, the synergistic coefficient (CTC) of the mixed agent was less than or equal to 80, which showed the antagonistic effect, and the synergistic coefficient (CTC) of the mixed agent was greater than 80 and less than 120, which showed the additive effect. The synergistic coefficient (CTC) of the mixed agent was calculated according to the formula (1), formula (2) and formula (3):

[0133]

[0134] In the formula:

[0135] ATI - the measured toxicity index of the mixed agent;

[0136] S - the LC 50 of the standard insecticide, unit: milligrams per liter (mg / L);

[0137] M - the LC 50 of the mixed agent, unit: milligrams per liter (mg / L)

[0138] TTI = TI A × PA +TI B ×P B (2)

[0139] wherein:

[0140] TTI - theoretical toxicity index of the mixture;

[0141] TI A - toxicity index of the A agent;

[0142] P A - percentage content of the A agent in the mixture, in percentage (%);

[0143] TI B - toxicity index of the B agent;

[0144] P B - percentage content of the B agent in the mixture, in percentage (%).

[0145]

[0146] wherein:

[0147] CTC - coefficient of toxicity;

[0148] ATI - actual toxicity index of the mixture;

[0149] TTI - theoretical toxicity index of the mixture.

[0150] When different pesticides are mixed, they usually exhibit three types of action, i.e. additive action, synergistic action and antagonistic action, but it is impossible to predict which type of action will occur. The composition described in the present application uses compound I and compound II as effective active ingredients, and is illustrated by the following biological test examples.

[0151] Insecticidal activity determination test of compound on T. urticae in laboratory

[0152] The test was carried out by using the mite slide immersion method to determine the activity of the insecticidal composition of Examples 1-2 on T. urticae.

[0153] Example 1: To verify the effect of different proportions of compound I and flumite on T. urticae, the indoor toxicity determination of different proportions of compound I and flumite on T. urticae was carried out. The corresponding concentrations were prepared according to the mass proportions in the table, and the indoor insecticidal test was carried out, and the test results are as follows:

[0154] Table 1 Toxicity determination results of compound I and flumite single agent and their mixture on T. urticae

[0155] Active ingredient Ratio Regression equation LC 50 ]]> Co-toxicity coefficient Evaluation Compound I — y = 3.8749 + 2.0618x 3.5131 — — Fluensulfone — y = 5.4543 + 1.9871x 0.5907 — — Compound I: Fluensulfone 50：1 y = 4.5113 + 1.7684x 1.8896 169.4832 Synergism Compound I: Fluensulfone 10：1 y = 5.1056 + 1.9491x 0.8827 274.5333 Synergism Compound I: Fluensulfone 1：1 y = 5.8633 + 1.8421x 0.3399 297.5433 Synergism Compound I: Fluensulfone 1：10 y = 5.9871 + 1.7382x 0.2704 236.3240 Synergism Compound I: Fluensulfone 1：50 y = 5.7528 + 1.8988x 0.4014 149.5991 Synergism

[0156] From the results of Table 1, it can be seen that the mixture of compound I and fluencarnifate at different proportions and dosages has obvious synergistic effect on T. urticae.

[0157] Example 2: To verify the effect of compound I and KII-9396 at different proportions and dosages on T. urticae, indoor toxicity determination of compound I and KII-9396 at different proportions and dosages on T. urticae was carried out. The corresponding concentrations were prepared according to the mass proportions in the table, and indoor insecticidal test was carried out. The test results are as follows:

[0158] Table 2 Toxicity determination results of compound I and KII-9396 single agent and their mixture on T. urticae

[0159] Active ingredient Ratio Regression equation LC 50 ]] Co-toxicity coefficient Evaluation Compound I — y = 3.8749 + 2.0618x 3.5131 — — KII-9396 — y = 5.0877 + 1.6033x 0.8817 — — Compound I: KII-9396 50：1 y = 4.4661 + 1.6635x 2.0939 158.5060 Synergism Compound I: KII-9396 10：1 y = 4.9666 + 1.3831x 1.0572 261.3904 Synergism Compound I: KII-9396 1：1 y = 5.5187 + 1.7244x 0.5003 281.7551 Synergism Compound I: KII-9396 1：10 y = 5.5105 + 1.6542x 0.4914 192.5352 Synergism Compound I: KII-9396 1：50 y = 5.4310 + 1.8889x 0.5913 151.3338 Synergism

[0160] From the results of Table 2, it can be seen that the mixture of compound I and KII-9396 at different proportions and dosages has obvious synergistic effect on T. urticae.

[0161] The above describes the embodiments of the present application. However, the present application is not limited to the above embodiments. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A composition comprising a compound I and a compound II, characterized in that, said compound II is spirodiclofen, said compound I has the following structure, I， a mass ratio of said compound I and said compound II is 50-1:1-50.

2. The composition of claim 1, wherein a mass ratio of said compound I and said compound II is 50:1, 40:1, 30:1, 20:1, 10:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:10, 1:20, 1:30, 1:40, or 1:

50.

3. The composition according to claim 1 or 2, characterized in that, at least one of deionized water, an organic solvent, an emulsifier, a dispersant, a wetting agent, a thickening agent, an antifoaming agent, a stabilizer, a binder, a disintegrant, an antifreezing agent, an anticaking agent, a suspending agent, a film forming agent, a preservative, a coloring agent, a high molecular capsule wall material, a pH adjustor, or a filler.

4. The composition of claim 1, wherein, said composition is prepared into a pesticide dosage form, which includes a wettable powder, a water dispersible granule, a suspension concentrate, an emulsion in water, a suspension seed coating, a microcapsule suspension concentrate, a microcapsule suspension-suspension concentrate, an emulsion in oil, a microemulsion, a dispersible liquid, or a granule.

5. Use of the composition according to any one of claims 1-4 for controlling pests in agriculture or non-agriculture.

6. Use according to claim 5, characterized in that, said pests are selected from Lepidoptera, Hemiptera, Coleoptera, Thysanoptera, Diptera, and mite pests.

7. A method of controlling pests in agriculture or non-agriculture, characterized by, comprising applying the composition according to any one of claims 1-4 to a plant where pests are present.

8. A composition for controlling an invertebrate pest, characterized by, which comprises a biologically effective amount of compound I, compound II selected from spirodiclofen, and at least one other component selected from a surfactant, a solid diluent, and a liquid diluent, and a mass ratio of said compound I and said compound II is 50-1:1-50; said compound I has the following structure, I。 9. A method for controlling an invertebrate pest, comprising contacting the pest with a composition comprising a compound of Formula (I) or a stereoisomer or a tautomer or a salt or a N-oxide thereof. comprising contacting an invertebrate pest or its environment with a biologically effective amount of the composition according to any one of claims 1-4.

10. A spray composition comprising the composition according to any one of claims 1-4 and a propellant.

11. A bait composition comprising the composition according to any one of claims 1-4 and one or more food materials.

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