Vacuum freeze-drying equipment for sodium tiopronin and drying method thereof

Abstract

The present application relates to the technical field of drying equipment, and particularly relates to a vacuum freeze-drying equipment for sodium tiopronin and a drying method thereof, which comprises a box assembly, a plate layer adjusting assembly, a placing assembly, a height adjusting assembly, a connecting assembly, a condenser and a rack; the plate layer adjusting assembly comprises a support, and hydraulic columns are arranged on both sides of the support; the device is simple to operate, has strong regulation and control performance, can meet the clamping and fixing of different models of the penicillin bottles, has high vacuum freeze-drying efficiency for the sodium tiopronin, has good effect and can meet the mass production demand; meanwhile, the inner wall of the placing frame can be scraped in advance, so that the condensation of external water vapor on the inner wall of the placing frame is avoided, the height adjustment accuracy, cleanliness and smoothness of the placing plate are higher, and the adjustment is more convenient and efficient; and the clamping height of the penicillin bottle can be adjusted according to the content of the sodium tiopronin in the penicillin bottle, the elastic clamping effect is better, and the anti-vibration and buffering effect is stronger.

Description

Technical Field

[0001] This invention relates to the field of drying equipment technology, and in particular to a vacuum freeze-drying device and drying method for sodium thiopronine. Background Technology

[0002] Vacuum freeze dryers are suitable for drying high-grade raw materials, Chinese herbal medicine slices, vegetables, food, fruits, chemicals, pharmaceutical intermediates, and other materials. They are also widely used in industrial manufacturing. During the freeze drying process, the growth of microorganisms and the action of enzymes cannot occur, thus maintaining the original properties. Therefore, vacuum freeze dryers are widely used in the pharmaceutical and food industries, and are particularly suitable for the production of large-scale pharmaceuticals and blood products.

[0003] Chinese invention patent 2020114315021 provides an atmospheric pressure freeze-drying device, comprising: a chamber, wherein the chamber defines a receiving cavity and has an opening on one side, and the chamber has an inlet and an outlet; a door, the door being openable / closable and connected to the opening side of the chamber; and a transmission device, at least a portion of which is disposed within the receiving cavity for transmitting the material to be dried from the inlet to the outlet. This freeze-drying device has low freezing efficiency and poor freezing effect.

[0004] Chinese invention patent 2021800360698 provides a vacuum freeze-drying apparatus and method capable of continuous vacuum freeze-drying in a short time; the vacuum freeze-drying apparatus of the present invention has an exhaust channel for performing vacuum suction, and the drying apparatus includes a tubular part, which is tubular and has an inlet and an outlet; the freeze-drying apparatus has poor controllability and is difficult to operate.

[0005] Vacuum freeze dryers used in pharmaceutical production are generally large in size. Multiple material trays are arranged at equal intervals on racks within the drying chamber, allowing for the processing of large quantities of material at once. However, when using a vacuum freeze dryer, the fixed material trays and their fixed spacing, coupled with the small distance between them, make it cumbersome to handle vials. Due to the varying sizes of vials, they are not easily placed evenly, and are prone to tipping over when moved, potentially causing spillage of the sodium thiopronine raw material or collisions with surrounding vials. This results in poor stability and makes handling vials difficult.

[0006] When clamping and fixing vials in practice, the center of gravity of the vial will be different depending on the content of sodium thioproline inside the vial. However, the existing technology lacks the function of adaptively adjusting the clamping height for vials with different center of gravity positions, thereby reducing the shock absorption and cushioning effect on the vial.

[0007] When using a refrigerant to freeze vials inside a drying chamber, the amount of refrigerant around the vials at different locations varies, resulting in different freezing temperatures. Consequently, the vacuum freeze-drying efficiency of sodium thiopronine inside the vials differs, ultimately reducing the freeze-drying effect.

[0008] Because the vials inside the drying chamber need to be replaced, water vapor from the outside will enter the drying chamber. After subsequent freezing, it will form ice and condense on the inner wall of the placement frame, which will hinder the subsequent adjustment of the clamping position, reduce the cleanliness and smoothness of the device, and reduce the vacuum freeze-drying effect of sodium thiopronine. Summary of the Invention

[0009] The purpose of this invention is to provide a vacuum freeze-drying apparatus and drying method for sodium thiopronine to solve the problems mentioned in the background art.

[0010] To achieve the above objectives, the present invention provides the following technical solution: a vacuum freeze-drying device for sodium thiopronine, comprising a housing assembly, a plate adjustment assembly, a placement assembly, a height adjustment assembly, a connecting assembly, a condenser, and a frame;

[0011] The plate adjustment assembly includes a bracket, with hydraulic columns on both sides of the bracket, and a first plate, a second plate, and a temperature compensation plate are spaced apart in the vertical direction inside the plate adjustment assembly.

[0012] The placement assembly includes a placement frame, inside which a placement plate is assembled. Multiple clamping seats are positioned above the placement plate. Electromagnetic blocks are provided on the inner walls of the clamping seats. A compression airbag is positioned at the other end of each electromagnetic block. A magnetic clamping plate is positioned at the end of the compression airbag away from the clamping seat. Pressure sensors are positioned on the opposite ends of the magnetic clamping plates. The other end of the compression airbag passes through the clamping seat and is connected to a transmission pipe. A top groove is formed on the top periphery of the placement plate. A scraper is slidably connected inside the top groove. A transfer pipe is provided inside the placement plate. One end of the transfer pipe is connected to the inner bottom of the top groove, and the other end is connected to the transmission pipe.

[0013] The height adjustment assembly includes an electric push rod, the top of which is provided with a mounting base, which is fixed to the bottom of the placement plate by bolts.

[0014] This device can not only adjust the clamping position according to the sodium thioproline inside the vial, but also adjust the gap according to the different positions of each placement plate, thereby adjusting the freezing efficiency. In addition, it can also scrape the inner wall of the placement frame to improve the cleanliness and smoothness of the inner wall.

[0015] Preferably, the plate adjustment assembly and the placement assembly are both disposed inside the housing assembly, the height adjustment assembly is disposed inside the placement assembly, the connecting assembly is disposed between the housing assembly and the condenser, and the housing assembly and the condenser are both disposed above the frame; the various structures cooperate with each other to achieve vacuum freeze-drying of sodium thiopronine.

[0016] Preferably, the first plate is fixedly disposed above the bracket, there are two second plates, and both second plates are disposed between the first plate and the temperature compensation plate. Protective strips are provided on both sides of the first and second plates, and protective plates are provided at the rear ends of the first and second plates. Slide rails are provided above the protective strips, and there are two slide rails. The placement frame is movably disposed between two adjacent slide rails, and a limit groove is provided at the position where the placement frame connects to the slide rail. This arrangement effectively improves the sliding stability of the plate adjustment assembly.

[0017] Preferably, the bracket is fixedly installed inside the housing assembly, and guide rods are provided at the four corners of the bracket surface. A fixed seat is provided at the top of the guide rod, and multiple slides are movably installed on the surface of the guide rod. A support seat is provided at the top of the hydraulic column. The slides and support seats are fixedly installed on one side of the second plate and the temperature compensation plate. The guide rods movably pass through the slides and extend into the interior of the fixed seat; this arrangement improves the limiting effect.

[0018] Preferably, the placement frame is located inside the plate adjustment assembly, the bottom of the placement frame is provided with a placement tray, the placement tray is provided with a placement rack, there are two magnetic clamps, and a vial is movably disposed between the two magnetic clamps, the surface of the placement rack is provided with multiple placement holes, and a weight sensor is provided inside the placement holes; thus, the clamping stability of the vial is effectively improved.

[0019] Preferably, a connecting spring is provided at the bottom of the top groove, the top of the connecting spring is fixedly connected to the bottom of the scraper, a return spring is provided on one side of the magnetic clamp, the other end of the return spring is fixedly connected to the side wall of the clamping seat, the return spring is located inside the compression air bladder, the pressure sensor is used to detect the pressure value between the magnetic clamp and the vial, and the side wall of the scraper matches the inner wall of the placement frame; to ensure the elastic clamping effect of each mechanism.

[0020] Preferably, the chamber assembly includes a drying chamber, which is disposed above the frame. A hinge is provided on one side of the drying chamber, and a door is provided at one end of the hinge. The surface of the door is provided with O-ring silicone rubber, and a sealing groove is provided at the position where the O-ring silicone rubber connects with the drying chamber to improve the sealing performance of the drying chamber.

[0021] Preferably, the connecting assembly includes a partition valve, one end of which is fixedly disposed above the condenser, and a delivery pipe is disposed at the end of the partition valve away from the condenser. The end of the delivery pipe away from the partition valve passes through the interior of the drying chamber, thereby improving the gas guiding effect.

[0022] Preferably, there are four electric push rods, and each of the four electric push rods is respectively located at the four corners of the surface of the placement plate. One end of the mounting base is provided with a lifting slider, and a groove is opened at the position where the lifting slider connects with the placement frame. The lifting slider matches the groove, thereby realizing the height adjustment of the placement plate.

[0023] A drying method for sodium thiopronine using a vacuum freeze-drying apparatus, wherein the specific steps are as follows:

[0024] S1. First, place the vials containing the filled sodium thioproline liquid evenly on the placement assembly;

[0025] S2. Next, open the box assembly and place the placement assembly containing the vial inside the plate adjustment assembly;

[0026] S3. Then close the chamber assembly, turn on the operating program of the vacuum freeze-drying equipment to perform timed pre-freezing, and after the pre-freezing is completed, turn on the vacuum system according to the set freeze-drying process.

[0027] S4. Then, through the cooperation between the box assembly, the connecting assembly and the condenser, the sodium thiopronine liquid inside the vial is sublimated.

[0028] S5. After sublimation is completed, the chamber assembly is opened again, and the distance between two adjacent placement components is adjusted by the plate adjustment assembly to facilitate the removal of the freeze-dried vial.

[0029] By further defining the drying method, the effect of vacuum freeze drying can be improved.

[0030] The technical effects and advantages of this invention are as follows:

[0031] 1. This invention allows for the manual insertion of multiple vials into placement holes on the surface of a placement rack, thereby evenly arranging the vials, clamping and fixing vials of different sizes, improving the stability of the vials during use, facilitating the installation and disassembly of the placement frame, and making it easier to place and retrieve the vials as a whole during use. The distance between the first plate, the second plate, and the temperature compensation plate can be adjusted, and the distance between two adjacent placement frames can also be adjusted, facilitating the placement and retrieval of vials.

[0032] 2. This invention controls the electric push rod on the height adjustment component, causing the electric push rod to drive the mounting base and the placement plate to move up and down together. This causes the mounting base to drive the lifting slider to slide up and down in the groove opened in the inner wall of the placement frame, thereby adjusting the clamping height of the clamping base to meet the purpose of clamping vials of different heights. Through the cooperation between the height adjustment component and the placement component, it is easy to adjust the height of the clamping base according to the different heights of the vials.

[0033] 3. This invention, through the use of a compressed air bladder and a scraper, features a simple operation, strong controllability, and the ability to clamp and fix different types of vials. It also achieves high efficiency and effectiveness in the vacuum freeze-drying of sodium thiopronine, meeting the needs of mass production. Furthermore, it pre-scrapes the inner wall of the placement frame, preventing external water vapor condensation and ensuring the accuracy of subsequent plate height adjustments. This results in improved cleanliness and smoothness, and more convenient and efficient adjustment. The clamping height of the vial can also be adjusted according to its sodium thiopronine content, providing better elastic clamping and stronger shock absorption. Most importantly, the gap between the two placement frames can be adjusted according to the temperature of the placement plates at different heights, thereby regulating the amount of refrigerant entering and ensuring the optimal vacuum freeze-drying effect on the vials. Attached Figure Description

[0034] Figure 1 This is a first-view schematic diagram of the overall structure of the present invention.

[0035] Figure 2 This is a second-view schematic diagram of the overall structure of the present invention.

[0036] Figure 3 This is a schematic diagram of the assembly structure of the plate adjustment component, the placement component, and the height adjustment component of the present invention.

[0037] Figure 4 This is a schematic diagram of the structure of the plate layer adjustment component of the present invention.

[0038] Figure 5 This is a schematic diagram of the assembly structure of the placement component and the height adjustment component of the present invention.

[0039] Figure 6 In this invention Figure 5 Enlarged view of point A.

[0040] Figure 7 This is a schematic diagram of the clamping base structure of the present invention.

[0041] Figure 8 This is a schematic diagram of the assembly structure of the plate adjustment component and the placement component of the present invention.

[0042] Figure 9 This is an exploded view of the component structure for the present invention.

[0043] Figure 10 In this invention Figure 9 Enlarged view of point B.

[0044] Figure 11 This is a front sectional view of the placement plate portion according to the second embodiment of the present invention.

[0045] In the diagram: 1. Chamber assembly; 101. Drying oven; 102. Door; 103. O-ring silicone rubber; 104. Hinge; 2. Sheet adjustment assembly; 201. Bracket; 202. First shelf; 203. Second shelf; 204. Temperature compensation plate; 205. Protective strip; 206. Protective plate; 207. Guide rod; 208. Slide; 209. Fixed seat; 210. Support seat; 211. Hydraulic column; 212. Slide rail; 3. Placement assembly; 301. Placement frame; 302. Placement tray; 303. Placement rack; 304. 305. Placement plate; 306. Clamping seat; 307. Compressed air bag; 308. Magnetic clamp; 309. Vial; 3010. Top groove; 3011. Scraper; 3012. Connecting spring; 3013. Transfer pipe; 3014. Return spring; 3015. Transfer pipe; 3016. Pressure sensor; 3017. Electromagnetic block; 4. Height adjustment assembly; 401. Electric push rod; 402. Mounting base; 403. Lifting slider; 5. Connecting assembly; 501. Diaphragm valve; 502. Delivery pipe; 6. Condenser; 7. Frame. Detailed Implementation

[0046] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0047] First Embodiment

[0048] like Figure 1 , Figure 2As shown, a vacuum freeze-drying apparatus for sodium thiopronine according to the present invention includes a housing assembly 1, a plate adjustment assembly 2, a placement assembly 3, a height adjustment assembly 4, a connecting assembly 5, a condenser 6, and a frame 7. The plate adjustment assembly 2 and the placement assembly 3 are both disposed inside the housing assembly 1, the height adjustment assembly 4 is disposed inside the placement assembly 3, and the connecting assembly 5 is disposed between the housing assembly 1 and the condenser 6. The housing assembly 1 and the condenser 6 are both disposed above the frame 7. The sublimation of the sodium thiopronine liquid inside the vial 308 is achieved through the cooperation of the housing assembly 1, the connecting assembly 5, and the condenser 6. This is achieved by using a clamping seat 305, a compression airbag 306, and a magnetic clamping plate 3. The components 307 and 308 work together. During the clamping process of the magnetic clamp 307 on the vial 308, the compression airbag 306 is compressed, thereby clamping and fixing vials 308 of different sizes. This facilitates the picking, placing and fixing of vials 308 during use, preventing the vials 308 from shaking or even being damaged during movement, and improving the stability of vials 308 during use. The placement component 3 and the plate adjustment component 2 work together, that is, the placement frame 301 and the slide rail 212 work together, which facilitates the picking and placing of vials 308 during use. The plate adjustment component 2 adjusts the distance between adjacent placement components 3, which facilitates the picking and placing of vials 308.

[0049] like Figure 3 , Figure 4 As shown, the plate adjustment assembly 2 includes a bracket 201, which is fixedly installed inside the housing assembly 1. Guide rods 207 are provided at the four corners of the surface of the bracket 201, and a fixed seat 209 is provided at the top of the guide rod 207. Multiple slides 208 are movably arranged on the surface of the guide rod 207. Hydraulic columns 211 are provided on both sides of the bracket 201, and a support seat 210 is provided at the top of the hydraulic column 211. Through the cooperation between the hydraulic column 211, the support seat 210, the guide rods 207 and the slides 208, the second plate 203 or the temperature compensation plate 204 are driven to move up and down, thereby adjusting the distance between the first plate 202, the second plate 203 and the temperature compensation plate 204, which facilitates the subsequent handling of vials 308.

[0050] like Figure 5 As shown, the placement component 3 includes a placement frame 301, which is disposed inside the plate adjustment component 2. A placement tray 302 is disposed at the bottom of the placement frame 301. A placement rack 303 is disposed inside the placement tray 302. A placement plate 304 is assembled inside the placement frame 301. Multiple clamping seats 305 are disposed above the placement plate 304. The placement tray 302, placement rack 303, placement plate 304 and clamping seats 305 cooperate with each other to facilitate the even placement of multiple vials 308. The placement frame 301 facilitates the movement and collection of multiple vials 308.

[0051] like Figure 4 As shown, the plate adjustment assembly 2 is provided with a first plate 202, a second plate 203 and a temperature compensation plate 204 at intervals in the vertical direction inside. The first plate 202 is fixedly installed above the bracket 201, and the slide 208 and the support 210 are both fixedly installed on one side of the second plate 203 and the temperature compensation plate 204. The sodium thioproline liquid inside the vial 308 is heated by setting the first plate 202 and the second plate 203, and the temperature compensation plate 204 is set to ensure that the space inside the drying oven 101 is in the same temperature environment.

[0052] like Figure 4 As shown, there are two second plates 203, and both second plates 203 are disposed between the first plate 202 and the temperature compensation plate 204. Protective strips 205 are provided on both sides of the first plate 202 and the second plate 203, and protective plates 206 are provided at the rear ends of the first plate 202 and the second plate 203. A slide rail 212 is provided above the protective strips 205. By providing protective strips 205 and protective plates 206 on both sides and at the rear ends of the first plate 202 and the second plate 203 respectively, the placement tray 302 is prevented from exceeding the surface of the first plate 202 and the second plate 203.

[0053] like Figure 4 As shown, the guide rod 207 moves through the slide 208 and extends into the interior of the fixed seat 209. There are six hydraulic columns 211, and three of them are located on one side of the bracket 201. The slide 208 moves along the guide rod 207 through the hydraulic columns 211, thereby adjusting the distance between the first plate layer 202, the second plate layer 203, and the temperature compensation plate 204.

[0054] like Figure 6 , Figure 7 As shown, the inner walls of both sides of the clamping seat 305 are provided with compression airbags 306. A magnetic clamping plate 307 is provided at the end of the compression airbag 306 away from the clamping seat 305. There are two magnetic clamping plates 307, and a vial 308 is movably disposed between the two magnetic clamping plates 307. The vial 308 is movably inserted into the interior of the placement rack 303. The surface of the placement rack 303 has multiple placement holes. By setting the clamping seat 305, compression airbags 306 and magnetic clamping plates 307 to cooperate with each other, the compression airbags 306 are compressed during the clamping process of the magnetic clamping plates 307 on the vial 308, thereby clamping and fixing vials 308 of different sizes, preventing the vials 308 from shaking or even being damaged during movement, and improving the stability of the vials 308 during use.

[0055] like Figure 8As shown, there are two slide rails 212, and the placement frame 301 is movably disposed between two adjacent slide rails 212. A limiting groove is provided at the position where the placement frame 301 connects with the slide rail 212. The placement frame 301 and the slide rail 212 cooperate with each other to facilitate the installation and disassembly of the placement frame 301.

[0056] like Figure 2 As shown, the chamber assembly 1 includes a drying chamber 101, which is located above the frame 7. A hinge 104 is provided on the left side of the drying chamber 101, and a door 102 is provided at one end of the hinge 104. The surface of the door 102 is provided with O-ring silicone rubber 103, and a sealing groove is provided at the position where the O-ring silicone rubber 103 connects with the drying chamber 101. By providing O-ring silicone rubber 103, the drying chamber 101 can be tightly fitted with the O-ring silicone rubber 103 during the process of closing the door 102, thereby improving the sealing performance of the chamber assembly 1 under vacuum.

[0057] like Figure 1 As shown, the connecting component 5 includes a diaphragm valve 501. One end of the diaphragm valve 501 is fixedly installed above the condenser 6. A delivery pipe 502 is provided at the end of the diaphragm valve 501 away from the condenser 6. The end of the delivery pipe 502 away from the diaphragm valve 501 passes through the interior of the drying chamber 101. By using the diaphragm valve 501 to isolate the drying chamber 101 from the condenser 6, it has the characteristics of good sealing, strong corrosion resistance, and long service life.

[0058] like Figure 9 , Figure 10 As shown, the height adjustment component 4 includes an electric push rod 401, a mounting base 402 at the top of the electric push rod 401, and a lifting slider 403 at one end of the mounting base 402. There are four electric push rods 401, and each of the four electric push rods 401 is respectively located at one of the four corners of the surface of the placement plate 302. The mounting base 402 is fixed to the bottom of the placement plate 304 by bolts. A groove is provided at the position where the lifting slider 403 connects to the placement frame 301, and the lifting slider 403 matches the groove. The electric push rod 401 drives the mounting base 402 and the lifting slider 403 to move up and down together, thereby adjusting the height of the lifting slider 403. The mounting base 402 fixes the electric push rod 401 to the placement plate 304, so that the placement plate 304 can slide up and down in the groove on the placement frame 301 together with the lifting slider 403, thereby adjusting the height of the clamping seat 305.

[0059] In use, multiple vials 308 are manually inserted into the placement holes on the surface of the placement rack 303 to evenly distribute the vials 308. To prevent the vials 308 from shaking or even being damaged during movement, a clamping seat 305, a compression airbag 306, and a magnetic clamping plate 307 are designed to work together. During the clamping process of the magnetic clamping plate 307 on the vials 308, the compression airbag 306 is compressed, thereby clamping and fixing vials 308 of different sizes, improving the stability of the vials 308 during use, and facilitating the picking, placing, and fixing of the vials 308 during use.

[0060] Manually open the box door 102. When installing the placement component 3, manually install the placement frame 301 on the surface of the slide rail 212, thereby placing the placement component 3 inside the plate adjustment component 2. The placement frame 301 and the slide rail 212 cooperate with each other, making it easy to install and remove the placement frame 301, thus facilitating the overall handling of the vial 308.

[0061] According to the different specifications of the vial 308, observe the height of the vial 308. By controlling the electric push rod 401 on the height adjustment component 4, the electric push rod 401 drives the mounting base 402 and the placement plate 304 to move up and down together. This causes the mounting base 402 to drive the lifting slider 403 to slide up and down in the groove opened in the inner wall of the placement frame 301, thereby adjusting the clamping height of the clamping seat 305. Through the cooperation between the height adjustment component 4 and the placement component 3, it is convenient to adjust the height of the clamping seat 305 according to the different heights of the vial 308.

[0062] Manually apply a push to the door 102 to close it with the drying chamber 101. By setting the O-ring silicone rubber 103, the drying chamber 101 can be tightly fitted with the O-ring silicone rubber 103 during the closing process of the door 102, improving the sealing performance of the chamber assembly 1 under vacuum. Then, start the operation program of the vacuum freeze dryer to perform timed pre-freezing. Pre-freezing is to fix the product so that it can be vacuum sublimated under vacuum conditions. After the pre-freezing is completed, according to the set freeze-drying process, start the vacuum system to put the condenser 6 into the pre-cooling stage. When the condenser 6 drops to -45°C, the vacuum can be drawn.

[0063] A diaphragm valve 501 is used to isolate the drying oven 101 from the condenser 6, providing excellent sealing, strong corrosion resistance, and long service life. When the pressure inside the drying oven 101 drops below 10 Pa, the sodium thioproline liquid inside the vial 308 can be heated through the first plate 202 and the second plate 203. A temperature compensation plate 204 ensures that the entire space inside the drying oven 101 is at the same temperature. The first plate 202 and the second plate 203 are made of special hollow plates, offering high strength and excellent sealing. The heat-conducting fluid circulation pipes inside the first plate 202 and the second plate 203 are of equal length, ensuring temperature uniformity and preventing deformation under long-term thermal expansion and contraction conditions. To ensure leak-proof performance and achieve optimal heat transfer area, the first plate 202 and the second plate 203 are highly flat and smooth, resulting in optimal heat transfer efficiency. Protective strips 205 and protective plates 206 are installed on the sides and rear ends of the first plate 202 and the second plate 203, respectively, to prevent the placement tray 302 from extending beyond the surfaces of the first plate 202 and the second plate 203. While the first plate 202 and the second plate 203 are being heated, the sodium thiopronine liquid in the vial 308 sublimates into water vapor. The condenser 6 then condenses and adsorbs the water vapor inside the drying chamber 101 onto its metal surface. This utilizes the water vapor pressure difference between the drying chamber 101 and the condenser 6 to freeze-dry the sodium thiopronine liquid inside the vial 308, achieving sublimation.

[0064] Open the cabinet door 102, and then raise the hydraulic column 211. The hydraulic column 211 drives the support seat 210 and causes the slide 208 to move upward along the guide rod 207, thereby driving the second plate 203 or the temperature compensation plate 204 to move upward together, increasing the distance between the two adjacent placement frames 301. Then, manually pull the placement frame 301 to slide it along the slide rail 212, thereby separating the placement component 3 from the plate adjustment component 2. Take out the placement component 3 to facilitate the removal of the freeze-dried vials 308. Through the cooperation of the hydraulic column 211, support seat 210, guide rod 207 and slide 208, the second plate 203 or the temperature compensation plate 204 are driven up and down respectively, thereby adjusting the distance between the first plate 202, the second plate 203 and the temperature compensation plate 204, and thus adjusting the distance between the two adjacent placement frames 301, making it easier to put in and take out the vials 308.

[0065] Second Embodiment

[0066] like Figure 1-11As shown, when clamping and fixing vials 308, the center of gravity of vials 308 varies due to the different contents of sodium thiopronine inside them, requiring the magnetic clamp 307 to clamp and fix them at different positions. Furthermore, when the condenser 6 delivers coolant to the housing assembly 1 along the connecting component 5 for freezing, the temperature of the multi-layer placement plates 304 at different positions varies, resulting in different vacuum freeze-drying effects inside the vials 308. If the gap at these positions is not adjusted in time, the vacuum freeze-drying effect on the vials 308 within the multi-layer placement plates 304 will be inconsistent, further affecting the processing effect of sodium thiopronine. Simultaneously, since the housing assembly 1 needs to be opened to remove and place vials 308, external water vapor can easily enter the drying chamber 101 when the door 102 is opened, and condense into ice blocks inside the placement frame 301 under vacuum freezing conditions. This hinders subsequent height adjustment of the placement plates 304, reducing the adjustment effect and the dryness and smoothness of the device.

[0067] To address the aforementioned issues, the vacuum freeze-drying equipment for sodium thiopronin further includes a pressure sensor 3015 positioned on the facing end surfaces of the magnetic clamp 307. The pressure sensor 3015 detects the pressure value between the magnetic clamp 307 and the vial 308. When the magnetic clamp 307 and its side wall are pressed against the vial 308, the pressure sensor 3015 detects the pressure value. When the temperature of the placement plate 304 at that position decreases, the volume of the gas inside the compression bladder 306 decreases due to thermal expansion and contraction, thus reducing the pressure applied by the magnetic clamp 307 to the vial 308 and consequently reducing the pressure value detected by the pressure sensor 3015.

[0068] The compression airbag 306 contains thermally expanding gas. The other end of the compression airbag 306 passes through the clamping seat 305 and is connected to a transmission pipe 3012. The transmission pipe 3012 is used for gas transmission. A top groove 309 is formed on the top periphery of the placement plate 304. A scraper 3010 is slidably connected inside the top groove 309. A transfer pipe 3014 is provided inside the placement plate 304. One end of the transfer pipe 3014 is connected to the inner bottom of the top groove 309, and the other end of the transfer pipe 3014 is connected to the transmission pipe 3012. When the air bladder 306 is compressed, the gas inside the air bladder 306 is transmitted to the top trough 309 along the transmission pipe 3012 and the transfer pipe 3014. The air pressure inside the top trough 309 increases and drives the scraper 3010 to move upward with the help of the air pressure. The scraper 3010 pre-scrapes the inner wall of the placement frame 301 to avoid the water vapor attached to the inner wall of the placement frame 301 freezing and forming ice blocks when the height of the placement plate 304 is adjusted later, which would hinder the movement of the placement plate 304.

[0069] An electromagnetic block 3016 is provided on the inner wall of the clamping base 305. The side wall of the electromagnetic block 3016 is fixedly connected to the side wall of the compressed air bag 306. The magnetic properties of the electromagnetic block 3016 and the magnetic clamping plate 307 facing each other are different. When the electromagnetic block 3016 is energized and becomes magnetic, the magnetic attraction force of the electromagnetic block 3016 on the magnetic clamping plate 307 causes the magnetic clamping plate 307 to move to the maximum distance closer to the electromagnetic block 3016. A weight sensor is provided inside the placement hole to detect the weight of the vial 308 and the sodium thiopronine inside. The top groove 309 has a connecting spring 3011 at its inner bottom. The top of the connecting spring 3011 is fixedly connected to the bottom of the scraper 3010. The connecting spring 3011 enables the scraper 3010 inside the top groove 309 to reset. The magnetic clamp 307 has a reset spring 3013 on one side. The other end of the reset spring 3013 is fixedly connected to the side wall of the clamping seat 305. The reset spring 3013 is located inside the compression airbag 306. The reset spring 3013 improves the reset performance of the magnetic clamp 307.

[0070] In use, first open the box door 102 as described in the first embodiment and pull out the placement frame 301. At this time, the electromagnetic block 3016 is energized and has magnetism. With the magnetic attraction of the electromagnetic block 3016 to the magnetic clamp 307, the magnetic clamp 307 is driven to squeeze the compression airbag 306 and move it to the maximum distance from the end closest to the electromagnetic block 3016. Then the two magnetic clamps 307 move away from each other and open. When the compression airbag 306 is compressed, the gas inside the compression airbag 306 enters the transmission pipe 3012 and flows along the transmission pipe. 3012 further reaches the transfer pipe 3014 and finally reaches the top trough 309. The air pressure at the bottom of the top trough 309 continuously increases, and the scraper 3010 moves upward with the help of the air pressure inside the top trough 309. When the scraper 3010 moves upward, it scrapes and cleans the inner wall of the placement frame 301, effectively removing the frozen water vapor from the inner wall of the placement frame 301 in advance, improving the cleanliness and smoothness of the inner wall of the placement frame 301, and avoiding the impact and obstruction when adjusting the height of the placement plate 304 later.

[0071] The vial 308 is then placed between two sets of magnetic clamps 307 and passed through the placement plate 304 into the placement hole inside the placement rack 303. The weight sensor inside the placement hole detects the weight value and indirectly obtains the weight of sodium thioproline inside the vial 308 based on this weight value and the weight value of the vial 308. In particular, the amount of sodium thioproline inside the vials 308 in the same set of placement plates 304 is the same, which facilitates the subsequent adjustment of the clamping position and freezing efficiency of the vial 308.

[0072] Once the center of gravity height of sodium thioproline inside vial 308 is obtained, the electric push rod 401 is activated, causing the top mounting base 402 to move upward. Simultaneously, the mounting base 402 moves upward, causing the top placement plate 304 to move upward. The placement plate 304 then moves upward, simultaneously causing the clamping seat 305 to move upward. The clamping seat 305 then moves upward, simultaneously causing the magnetic clamping plate 307 to move upward. When the magnetic clamping plate 307 reaches the appropriate height, the electromagnetic block 3016 is de-energized, and the system resets. Under the elastic force of the spring 3013, the magnetic clamp 307 moves closer to the end of the vial 308 and presses against the side wall of the vial 308. The pressure sensor 3015 detects that the pressure value has reached the maximum pressure value. This process effectively adjusts the clamping position of the magnetic clamp 307 on the vial 308. Furthermore, the compression airbag 306 and the return spring 3013 enhance the shock absorption and buffering effect when the vial 308 shakes, ensuring the safety and stability of the vial 308.

[0073] After clamping and securing vial 308, push the placement frame 301 back and close the door 102. The condenser 6 starts and introduces refrigerant into the drying chamber 101 along the connecting assembly 5. The refrigerant then performs vacuum freeze-drying of the sodium thiopronine inside the drying chamber 101. Simultaneously, as the temperature inside the drying chamber 101 decreases, the volume of the gas inside the compression bladder 306 continuously decreases due to thermal expansion and contraction. Therefore, the volume of the compression bladder 306 continuously decreases, and the force exerted by the compression bladder 306 on the magnetic clamp 307 continuously decreases. As the magnetic clamp 307 exerts less pressure on the vial 308, the pressure value detected by the pressure sensor 3015 decreases continuously. The hydraulic column 211 is activated and drives the support seat 210 to move downward. The support seat 210 drives the corresponding placement frame 301 to move downward continuously. The gap between adjacent placement frames 301 decreases continuously, and the freezing effect of the refrigerant on the vial 308 inside the placement frame 301 at that position continuously recovers to the initial value, thereby improving the vacuum freeze-drying effect of sodium thiopronine inside the vial 308.

[0074] Specifically, if the freezing effect inside the placement frame 301 at a certain height does not meet the requirements, the temperature value at the end of the placement plate 304 will be greater than the required freezing temperature value. The thermal expansion gas inside the compression bladder 306 will increase in volume due to the principle of thermal expansion and contraction. Consequently, the volume of the compression bladder 306 will increase accordingly. The compression bladder 306 will drive the magnetic clamp 307 at the end to move closer to the vial 308. The pressure value detected by the pressure sensor 3015 will increase and exceed the preset pressure value. This indicates that the temperature value at that position has increased and cannot meet the vacuum freeze-drying effect of sodium thiopronine inside the vial 308 at the corresponding position.

[0075] The hydraulic column 211 at the corresponding height is activated, driving the top support 210 to move upward. The upward movement of the support 210 drives the top placement frame 301 to move upward, increasing the gap between the placement frame 301 at this position and the top placement frame 301. This increases the amount of refrigerant inside the drying chamber 101 entering the placement plate 304 through the gap between the two, thus increasing the vacuum freeze-drying efficiency of the refrigerant on the sodium thiopronine inside the vial 308 at this position. This effectively improves adaptability and spot freezing effect, making operation simpler and controllable. When the temperature of the placement plate 304 at this position decreases, the volume of the thermally expanding gas inside the compression bladder 306 decreases due to thermal expansion and contraction. This reduces the squeezing force of the magnetic clamp 307 on the vial 308 caused by the compression bladder 306. The pressure value detected by the pressure sensor 3015 decreases to the preset pressure value, and the hydraulic column 211 moves downward to a suitable height, thereby ensuring the freezing temperature and freezing effect at this position.

[0076] After the vacuum freeze-drying of sodium thioproline inside vial 308 is completed, open the chamber door 102, remove the placement frame 301, and the electromagnetic block 3016 is energized and becomes magnetic. The magnetic attraction of the electromagnetic block 3016 to the magnetic clamp 307 causes the magnetic clamp 307 to move relative to it and detach from the clamping and fixing of vial 308. Remove vial 308 to complete the vacuum freeze-drying of sodium thioproline inside vial 308. Replace with a new vial 308 and repeat the above process to complete the subsequent processing.

[0077] This device is simple to operate and highly adjustable, capable of clamping and fixing different types of vials 308. It also offers high efficiency and effectiveness in the vacuum freeze-drying of sodium thiopronine, meeting the needs of mass production. Furthermore, it can pre-scrape the inner wall of the placement frame 301 to prevent external water vapor condensation, which could reduce the height adjustment accuracy of the subsequent placement plate 304. This results in better cleanliness and smoothness, and more convenient and efficient adjustment. The device can also adjust the clamping height of the vial 308 according to its sodium thiopronine content, providing better elastic clamping and stronger shock absorption. Most importantly, it can adjust the gap between the two placement frames 301 according to the temperature of the placement plates 304 at different heights, thereby regulating the amount of refrigerant entering and ensuring the optimal vacuum freeze-drying effect on the vial 308.

[0078] Third Embodiment

[0079] A drying method for sodium thiopronine using a vacuum freeze-drying apparatus, wherein the specific steps are as follows:

[0080] S1. First, evenly place the vials 308 filled with sodium thioproline liquid on the placement component 3.

[0081] S2. Next, open the box assembly 1 and place the placement assembly 3 containing the vial 308 inside the shelf adjustment assembly 2.

[0082] S3. Then close the chamber assembly 1, turn on the operation program of the vacuum freeze dryer to perform timed pre-freezing, and after the pre-freezing is completed, turn on the vacuum system according to the set freeze-drying process.

[0083] S4. Then, through the cooperation between the housing assembly 1, the connecting assembly 5 and the condenser 6, the sodium thiopronine liquid inside the vial 308 is sublimated.

[0084] S5. After sublimation is completed, open the chamber assembly 1 again and adjust the distance between the two adjacent placement assemblies 3 through the plate adjustment assembly 2 to facilitate the removal of the freeze-dried vials 308.

[0085] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A vacuum freeze-drying apparatus for sodium thiopronine, characterized in that: Includes housing assembly, shelf adjustment assembly, placement assembly, height adjustment assembly, connection assembly, condenser, and rack; The plate adjustment assembly includes a bracket, with hydraulic columns on both sides of the bracket, and a first plate, a second plate, and a temperature compensation plate are spaced apart in the vertical direction inside the plate adjustment assembly. The placement assembly includes a placement frame, inside which a placement plate is assembled. Multiple clamping seats are positioned above the placement plate. Electromagnetic blocks are provided on the inner walls of the clamping seats. A compression airbag is positioned at the other end of each electromagnetic block. A magnetic clamping plate is positioned at the end of the compression airbag away from the clamping seat. Pressure sensors are positioned on the opposite ends of the magnetic clamping plates. The other end of the compression airbag passes through the clamping seat and is connected to a transmission pipe. A top groove is formed on the top periphery of the placement plate. A scraper is slidably connected inside the top groove. A transfer pipe is provided inside the placement plate. One end of the transfer pipe is connected to the inner bottom of the top groove, and the other end is connected to the transmission pipe. The height adjustment assembly includes an electric push rod, the top of which is provided with a mounting base, which is fixedly mounted to the bottom of the placement plate by bolts; The bottom of the top groove is provided with a connecting spring, the top of which is fixedly connected to the bottom of the scraper. A return spring is provided on one side of the magnetic clamp, and the other end of which is fixedly connected to the side wall of the clamping seat. The return spring is located inside the compression bladder. The pressure sensor is used to detect the pressure value between the magnetic clamp and the vial. The side wall of the scraper matches the inner wall of the placement frame.

2. The vacuum freeze-drying equipment for sodium thiopronine according to claim 1, characterized in that: The plate adjustment assembly and the placement assembly are both located inside the housing assembly. The height adjustment assembly is located inside the placement assembly. The connecting assembly is located between the housing assembly and the condenser. The housing assembly and the condenser are both located above the frame.

3. The vacuum freeze-drying equipment for sodium thiopronine according to claim 1, characterized in that: The first plate is fixedly installed above the bracket. There are two second plates, and both second plates are installed between the first plate and the temperature compensation plate. Protective strips are installed on both sides of the first and second plates. Protective plates are installed at the rear ends of the first and second plates. There are two slide rails installed above the protective strips. The placement frame is movably installed between two adjacent slide rails. A limit groove is provided at the position where the placement frame connects to the slide rail.

4. The vacuum freeze-drying equipment for sodium thiopronine according to claim 1, characterized in that: The bracket is fixedly installed inside the housing assembly. Guide rods are provided at the four corners of the bracket surface. A fixed seat is provided at the top of the guide rod. Multiple slides are movably installed on the surface of the guide rod. A support seat is provided at the top of the hydraulic column. The slides and support seats are fixedly installed on one side of the second plate and the temperature compensation plate. The guide rods movably pass through the slides and extend into the interior of the fixed seat.

5. The vacuum freeze-drying equipment for sodium thiopronine according to claim 1, characterized in that: The placement frame is located inside the plate adjustment assembly. The bottom of the placement frame is provided with a placement tray. The placement tray is provided with a placement rack. There are two magnetic clamps, and a vial is movably arranged between the two magnetic clamps. The surface of the placement rack is provided with multiple placement holes, and a weight sensor is provided inside each placement hole.

6. The vacuum freeze-drying equipment for sodium thiopronine according to claim 1, characterized in that: The chamber assembly includes a drying chamber, which is located above the frame. A hinge is provided on one side of the drying chamber, and a door is provided at one end of the hinge. The surface of the door is covered with O-ring silicone rubber, and a sealing groove is provided at the position where the O-ring silicone rubber connects to the drying chamber.

7. The vacuum freeze-drying equipment for sodium thiopronine according to claim 1, characterized in that: The connecting assembly includes a diaphragm valve, one end of which is fixedly disposed above the condenser, and a delivery pipe is disposed at the end of the diaphragm valve away from the condenser. The end of the delivery pipe away from the diaphragm valve passes through the interior of the drying oven.

8. The vacuum freeze-drying equipment for sodium thiopronine according to claim 1, characterized in that: There are four electric push rods, and each of the four electric push rods is respectively set at the four corners of the surface of the placement plate. One end of the mounting base is provided with a lifting slider. A groove is opened at the position where the lifting slider connects with the placement frame, and the lifting slider matches the groove.

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