A Chinese medicine composition for treating insomnia caused by liver depression and fire syndrome and its application

Abstract

The present invention provides a Chinese medicine composition for treating insomnia caused by liver depression and fire syndrome. The present invention enriches, purifies and compates Chinese medicine prescriptions according to the compatibility principle of traditional Chinese medicine to effectively treat insomnia caused by liver depression and fire syndrome. The results of animal experiments show that the effect of the Chinese medicine composition provided by the present invention on treating insomnia caused by liver depression and fire syndrome is significantly better than that of the original prescription.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating insomnia caused by liver depression and fire syndrome and an application thereof. Background Art

[0002] With the continuous acceleration of modern life, modern people are under great hidden pressure in life, diet, work, etc. Various reasons can easily cause us to consume body fluids, resulting in yin deficiency and hyperactivity of fire in the body, emotional frustration, liver depression and qi stagnation, which will generate fire over time, disturb the meridians and cause insomnia.

[0003] At present, people often use chemical drugs such as estazolam and melatonin, but do not fundamentally treat this syndrome from the perspective of traditional Chinese medicine. However, when treating insomnia from the perspective of traditional Chinese medicine, most of the traditional Chinese medicine prescriptions are prepared by water extraction, with a large dosage and insignificant efficacy. Summary of the invention

[0004] In view of this, the technical problem to be solved by the present invention is to provide a traditional Chinese medicine composition for treating insomnia caused by liver depression and fire syndrome and its application. The effect of the traditional Chinese medicine composition provided by the present invention on treating insomnia caused by liver depression and fire syndrome is significantly better than that of the original prescription.

[0005] The present invention provides a traditional Chinese medicine composition for treating insomnia caused by liver depression and fire syndrome, which is composed of the following traditional Chinese medicine extracts in parts by weight:

[0006] 1-5 parts of Chinese herbal medicine extract A, 2-14 parts of Chinese herbal medicine extract B, 2-18 parts of Chinese herbal medicine extract C, 1-3 parts of Chinese herbal medicine extract D;

[0007] The preparation method of Chinese medicine extract A comprises the following steps:

[0008] Mixing the immature orange peel, dried orange peel and water, extracting by steam distillation, and collecting volatile oil;

[0009] The volatile oil is mixed with β-cyclodextrin and water, passed through a colloid mill, and dried to obtain a Chinese medicine extract A;

[0010] The preparation method of Chinese medicine extract B comprises the following steps:

[0011] Extract bamboo shavings and dried orange peel with ethanol and water solution combined with ultrasound to obtain Chinese medicine extract B;

[0012] The preparation method of Chinese medicine extract C comprises the following steps:

[0013] Mixing pinellia tuber, bamboo shavings, immature bitter orange, dried orange peel, liquorice and poria for water extraction to obtain Chinese medicine extract C;

[0014] The preparation method of Chinese medicine extract D comprises the following steps:

[0015] Tangerine peel, liquorice and Poria cocos are crushed to obtain Chinese medicine extract D.

[0016] Preferably, the Chinese medicine composition is composed of the following Chinese medicine extracts in parts by weight:

[0017] The Chinese herbal extract A comprises 5 parts, the Chinese herbal extract B comprises 2 parts, the Chinese herbal extract C comprises 18 parts, and the Chinese herbal extract D comprises 2 parts.

[0018] Preferably, in the preparation method of the Chinese medicine extract A, the mass ratio of Citrus aurantium to Citrus reticulatae is 1:0.5-1.5;

[0019] The mass ratio of the total mass of the immature orange and dried orange peel to water is 1:8-10;

[0020] The mass ratio of the volatile oil, beta-cyclodextrin and water is 1:4 to 8:1.

[0021] Preferably, in the method for preparing the Chinese herbal extract A, the extraction time by steam distillation is 3 to 7 hours.

[0022] Preferably, in the preparation method of the Chinese medicine extract B, the mass ratio of bamboo shavings to tangerine peel is 5:1-5;

[0023] The volume percentage of the ethanol aqueous solution is 50-90%.

[0024] Preferably, in the preparation method of the traditional Chinese medicine extract B, the ultrasonic extraction time is 20 to 40 minutes.

[0025] Preferably, in the preparation method of the traditional Chinese medicine extract C, the mass ratio of Pinellia tuber, Rhizoma Anemarrhenae, Immature Citrus aurantium, Citrus reticulatae, Radix Glycyrrhizae and Poria cocos is 2:1-5:1-5:4-8:1-5:1-5.

[0026] Preferably, in the preparation method of the Chinese medicine extract C, the water extraction is performed by reflux extraction twice, and in the first reflux extraction, the mass ratio of the total mass of Pinellia tuber, Rhizoma Anemarrhenae, Immature Citrus Aurantium, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Poria cocos to water is 1:8-12, and the extraction time is 2-4 hours;

[0027] During the second reflux extraction, the total mass ratio of Pinellia tuber, Rhizoma Anemarrhenae, Immature Citrus aurantium, Citrus reticulatae, Radix Glycyrrhizae and Poria to water is 1:6-10, and the extraction time is 1-3h.

[0028] Preferably, in the preparation method of the traditional Chinese medicine extract D, the mass ratio of dried tangerine peel, licorice and poria is 3:1-5:0.3-0.75.

[0029] The present invention also provides an application of the Chinese medicine composition in preparing a medicine for treating insomnia caused by liver depression and fire syndrome.

[0030] Compared with the prior art, the invention provides a Chinese medicine composition for treating insomnia caused by liver depression and fire syndrome, which is composed of the following Chinese medicine extracts in parts by weight: 1-5 parts of Chinese medicine extract A, 2-14 parts of Chinese medicine extract B, 2-18 parts of Chinese medicine extract C, and 1-3 parts of Chinese medicine extract D; the preparation method of Chinese medicine extract A comprises the following steps: mixing immature bitter orange, dried orange peel and water, extracting by steam distillation, and collecting volatile oil; mixing the volatile oil with beta-cyclodextrin and water, passing through a colloid mill, and drying to obtain Chinese medicine extract A; the preparation method of Chinese medicine extract B comprises the following steps: extracting bamboo shavings and dried orange peel by ethanol aqueous solution combined with ultrasound to obtain Chinese medicine extract B; the preparation method of Chinese medicine extract C comprises the following steps: mixing pinellia tuber, bamboo shavings, immature bitter orange, dried orange peel, liquorice and poria cocos, extracting by water to obtain Chinese medicine extract C; the preparation method of Chinese medicine extract D comprises the following steps: crushing dried orange peel, liquorice and poria cocos to obtain Chinese medicine extract D. The present invention enriches, purifies and compates the Chinese medicine formula according to the compatibility principle of traditional Chinese medicine to effectively treat insomnia caused by liver depression and fire syndrome. The results of animal experiments show that the effect of the Chinese medicine composition provided by the present invention on treating insomnia caused by liver depression and fire syndrome is significantly better than that of the original prescription. DETAILED DESCRIPTION

[0031] The present invention provides a traditional Chinese medicine composition for treating insomnia caused by liver depression and fire syndrome, which is composed of the following traditional Chinese medicine extracts in parts by weight:

[0032] 1-5 parts of Chinese herbal medicine extract A, 2-14 parts of Chinese herbal medicine extract B, 2-18 parts of Chinese herbal medicine extract C, 1-3 parts of Chinese herbal medicine extract D;

[0033] The preparation method of Chinese medicine extract A comprises the following steps:

[0034] Mixing the immature orange peel, dried orange peel and water, extracting by steam distillation, and collecting volatile oil;

[0035] The volatile oil is mixed with β-cyclodextrin and water, passed through a colloid mill, and dried to obtain a Chinese medicine extract A;

[0036] The preparation method of Chinese medicine extract B comprises the following steps:

[0037] Extract bamboo shavings and dried orange peel with ethanol and water solution combined with ultrasound to obtain Chinese medicine extract B;

[0038] The preparation method of Chinese medicine extract C comprises the following steps:

[0039] Mixing pinellia tuber, bamboo shavings, immature bitter orange, dried orange peel, liquorice and poria for water extraction to obtain Chinese medicine extract C;

[0040] The preparation method of Chinese medicine extract D comprises the following steps:

[0041] Tangerine peel, liquorice and Poria cocos are crushed to obtain Chinese medicine extract D.

[0042] The Chinese medicine composition for treating insomnia caused by liver depression and fire syndrome provided by the present invention comprises a Chinese medicine extract A. The preparation method of the Chinese medicine extract A comprises the following steps:

[0043] Mixing the immature orange peel, dried orange peel and water, extracting by steam distillation, and collecting volatile oil;

[0044] The volatile oil is mixed with β-cyclodextrin and water, passed through a colloid mill, and dried to obtain a traditional Chinese medicine extract A.

[0045] Specifically, the present invention firstly mixes the immature orange, the dried orange peel and water, extracts them by steam distillation, and collects the volatile oil.

[0046] Among them, the mass ratio of Citrus aurantium and dried orange peel is 1:0.5-1.5, preferably 1:0.5, 1:1, 1:1.5, or any value between 1:0.5 and 1.5; the mass ratio of the total mass of Citrus aurantium and dried orange peel to water is 1:8-10, preferably 1:8, 1:9, 1:10, or any value between 1:8 and 10; the time of steam distillation extraction is 3 to 7 hours, preferably 3, 5, 7, or any value between 3 and 7 hours.

[0047] After obtaining the volatile oil, β-cyclodextrin and water are added to the volatile oil and stirred at a constant speed with a magnetic stirrer, and the inclusion mixture is passed through a colloid mill for 3 times, and the liquid is evaporated to dryness to obtain a traditional Chinese medicine extract A. The mass ratio of the volatile oil, β-cyclodextrin and water is 1:4 to 8:1, preferably 1:4:1, 1:6:1, 1:8:1, or any value between 1:4 and 8:1.

[0048] The preparation method of Chinese medicine extract B comprises the following steps:

[0049] Extract bamboo shavings and dried orange peel with ethanol and water solution combined with ultrasound to obtain Chinese medicine extract B;

[0050] First, the bamboo shavings and tangerine peel are crushed and sieved, and then mixed with an ethanol aqueous solution and ultrasonically extracted. The mass ratio of the bamboo shavings to the tangerine peel is 5:1-5, preferably 5:1, 5:3, 5:5, or any value between 5:1-5; the volume percentage of the ethanol aqueous solution is 50%-90%, preferably 50%, 70%, 90%, or any value between 50%-90%. The ultrasonic extraction time is 20-40 minutes, preferably 20, 30, 40, or any value between 20-40 minutes.

[0051] After the ultrasonic extraction is completed, the extract is filtered, the ethanol is recovered, the extract is concentrated, and the concentrate is freeze-dried to obtain the Chinese medicine extract B.

[0052] The preparation method of Chinese medicine extract C comprises the following steps:

[0053] Mixing pinellia tuber, bamboo shavings, immature bitter orange, dried orange peel, liquorice and poria for water extraction to obtain Chinese medicine extract C;

[0054] The present invention firstly mixes pinellia tuber, bamboo shavings, immature bitter orange, tangerine peel, liquorice, tuckahoe and water to obtain a mixture. The mass ratio of pinellia tuber, bamboo shavings, immature bitter orange, tangerine peel, liquorice and tuckahoe is 2:1-5:1-5:4-8:1-5:1-5, preferably 2:3:3:6:3:3, or any value between 2:1-5:1-5:4-8:1-5:1-5.

[0055] The mixture is subjected to reflux extraction. In the present invention, it is preferred to perform reflux extraction twice. During the first reflux extraction, the mass ratio of the total mass of Pinellia, Rhizoma Anemarrhenae, Immature Citrus Aurantium, Tangerine Peel, Glycyrrhiza uralensis and Poria to water is 1:8-12, preferably 1:8, 1:10, 1:12, or any value between 1:8 and 12, and the extraction time is 2-4h, preferably 2, 3, 4, or any value between 2 and 4h; during the second reflux extraction, the mass ratio of the total mass of Pinellia, Rhizoma Anemarrhenae, Immature Citrus Aurantium, Tangerine Peel, Glycyrrhiza uralensis and Poria to water is 1:6-10, preferably 1:6, 1:8, 1:10, or any value between 1:6 and 10, and the extraction time is 1-3h, preferably 1, 2, 3, or any value between 1-3h.

[0056] The decoctions from the two reflux extractions were combined, concentrated to a 1.20% clear paste, dried under reduced pressure, and the dry paste was crushed to obtain the Chinese medicine extract C.

[0057] The preparation method of Chinese medicine extract D comprises the following steps:

[0058] Tangerine peel, liquorice and Poria cocos are crushed to obtain Chinese medicine extract D.

[0059] The mass ratio of dried tangerine peel, liquorice and poria is 3:1-5:0.3-0.75, preferably 3:1:0.3, 3:3:0.5, 3:5:0.75, or any value between 3:1-5:0.3-0.75. The pulverization is low temperature pulverization at a temperature of 10-15°C and then sieved through a 120-mesh sieve to obtain a Chinese medicine extract D.

[0060] The Chinese medicine composition provided by the present invention comprises 1 to 5 parts of Chinese medicine extract A, preferably 1, 2, 3, 4, 5, or any value between 1 and 5 parts;

[0061] The Chinese medicine composition provided by the present invention further comprises 2 to 14 parts of Chinese medicine composition B, preferably 2, 4, 5, 6, 8, 10, 12, 14, or any value between 2 and 14 parts;

[0062] The Chinese medicine composition provided by the present invention further comprises 2 to 18 parts of Chinese medicine composition C, preferably 2, 4, 5, 6, 8, 10, 12, 14, 16, 18, or any value between 2 and 18 parts;

[0063] The traditional Chinese medicine composition provided by the present invention further comprises 1 to 3 parts of a traditional Chinese medicine extract D, preferably 1, 2, 3, or any value between 1 and 3 parts.

[0064] In some preferred embodiments of the present invention, the Chinese medicine composition provided by the present invention is composed of the following Chinese medicine extracts in parts by weight:

[0065] The Chinese herbal extract A comprises 5 parts, the Chinese herbal extract B comprises 2 parts, the Chinese herbal extract C comprises 18 parts, and the Chinese herbal extract D comprises 2 parts.

[0066] The present invention also provides an application of the Chinese medicine composition in preparing a medicine for treating insomnia caused by liver depression and fire syndrome.

[0067] The present invention enriches, purifies and compates the Chinese medicine formula according to the compatibility principle of traditional Chinese medicine to effectively treat insomnia caused by liver depression and fire syndrome. The results of animal experiments show that the effect of the Chinese medicine composition provided by the present invention on treating insomnia caused by liver depression and fire syndrome is significantly better than that of the original prescription.

[0068] In order to further understand the present invention, the Chinese medicine composition for treating insomnia caused by liver depression and fire transformation provided by the present invention and the preparation method thereof are described below in conjunction with examples. The protection scope of the present invention is not limited by the following examples.

[0069] 1. A method for preparing a Chinese medicine extract A for treating insomnia caused by liver depression and fire syndrome:

[0070] Take 3 parts of Citrus aurantium and 3 parts of dried tangerine peel, add them into water with a solid-liquid ratio of 1:10, extract by steam distillation for 5 hours, collect the volatile oil, add 4 times the amount of β-cyclodextrin and 1 times the amount of water, stir at a constant speed with a magnetic stirrer for 1 hour, then pass the included mixture through a colloid mill 3 times, evaporate the liquid to dryness, and obtain extract A.

[0071] 2. A method for preparing a Chinese medicine extract B for treating insomnia caused by liver depression and fire syndrome:

[0072] Take 5 parts of bamboo shavings and 3 parts of dried tangerine peel, crush them, pass through a 40-mesh sieve, add 70% ethanol, and extract by ultrasonic for 30 minutes, filter, recover ethanol, concentrate the extract, and freeze-dry the concentrate to obtain extract B.

[0073] 3. A method for preparing a Chinese medicine extract C for treating insomnia caused by liver depression and fire syndrome:

[0074] Take 2 parts of Pinellia, 3 parts of Rhizoma Anemarrhenae, 3 parts of Immature Citrus aurantium, 6 parts of Pericarpium Citri Reticulatae, 3 parts of Radix Glycyrrhizae, and 3 parts of Poria, and reflux extract twice, the first time with 10 times the amount of water for 3 hours, the second time with 8 times the amount of water for 2 hours, combine the decoctions, concentrate to a clear paste of 1.20, dry under reduced pressure, and crush the dry paste to obtain Extract C.

[0075] 4. A method for preparing a Chinese medicine extract D for treating insomnia caused by liver depression and fire syndrome:

[0076] Take 3 parts of dried tangerine peel, 3 parts of licorice, and 0.5 parts of Poria cocos, grind them at low temperature, pass them through a 120-mesh sieve, and set aside to obtain extract D.

[0077] 5. Mix Chinese medicinal extract A for treating insomnia caused by liver depression transforming into fire syndrome, Chinese medicinal extract B, Chinese medicinal extract C and Chinese medicinal extract D, and obtain the product.

[0078] Examples 1 to 9

[0079] According to the formula in Table 1, Chinese medicinal extract A, Chinese medicinal extract B, Chinese medicinal extract C and Chinese medicinal extract D are mixed to obtain a Chinese medicinal composition for treating insomnia caused by liver depression and fire syndrome.

[0080] Table 1

[0081] Example Chinese medicine composition Chinese herbal medicine extract A Chinese herbal medicine extract B Chinese herbal medicine extract C Chinese herbal medicine extract D 1 Ⅰ 1 2 2 1 2 Ⅱ 1 8 10 2 3 Ⅲ 1 14 18 3 4 Ⅳ 3 2 10 3 5 Ⅴ 3 8 18 1 6 Ⅵ 3 14 2 2 7 Ⅶ 5 2 18 2 8 Ⅷ 5 8 2 3 9 Ⅸ 5 14 10 1

[0082] The specific method for conducting a comparative pharmacodynamics experiment on the Chinese medicine compositions I to IX prepared in the above Examples 1 to 9 is as follows:

[0083] 1. Experimental Materials

[0084] Anshen Wendan Pills: Jilin Hengjin Pharmaceutical Co., Ltd. (purchased from Jilin Pharmacy); Wendan Decoction preparation: prepared by Jilin Xiuzhen Pharmaceutical New Drug Development Co., Ltd.; melatonin: By-Health (purchased from Jishen Pharmacy); pentobarbital: packaged by Sigma; Chinese medicine compositions I, II, III, IV, V, VI, VII, VIII, IX Jilin Xiuzhen Pharmaceutical New Drug Development Co., Ltd.

[0085] Prescription for Wen Dan Tang preparation: 27.60g of Pinellia ternata, 27.60g of Rhizoma Anemarrhenae, 27.60g of Citrus aurantium stir-fried with bran, 41.40g of dried tangerine peel, 55.20g of ginger, and 13.80g of stir-fried licorice.

[0086] Add 8 times the amount of water to the above six ingredients and boil them once. Boil for 1 hour, filter and concentrate the filtrate to an extract with a relative density of 1.15-1.20. Add appropriate amount of auxiliary materials, mix and make granules. Mix well and make 1000g.

[0087] 2. Experimental Animals:

[0088] 140 healthy female Wistar rats, weighing 180-220 g, were purchased from Changchun Yisi Laboratory Animal Science and Technology Co., Ltd.

[0089] 3. Instruments:

[0090] AE-240 precision electronic balance (Mettler, Switzerland), Optima-MAX-XP desktop ultracentrifuge (Thermo, USA), AQT automatic fluorescent immunoassay analyzer (Radiomerter, Denmark).

[0091] 4. Grouping:

[0092] The rats were adaptively fed for 1 week, and then 140 rats were randomly divided into a blank group, a model group, and an Anshen Wendan pill group (0.5 g kg -1 ·d -1 ), Wendan decoction group (0.5 g·kg -1 ·d -1 ), melatonin group (0.1 g kg -1 ·d -1 ) and Chinese medicine composition groups I to IX (all 0.5 g·kg -1 ·d -1 ), 10 in each group.

[0093] 5. Modeling

[0094] The liver depression and fire syndrome was induced by tail clamp stimulation. Except for the blank group, the other groups were given tail clamp stimulation at 9 am on time, for 10 minutes each time, once every 2 hours, 4 times a day, and continued for one week. In the second week, tail clamp stimulation was given at 9 am on time, for 10 minutes each time, once every 1 hour, 8 times a day, and continued for one week.

[0095] 6. Administration

[0096] One week after modeling, the rats in the normal group and model group were given distilled water (5 ml kg -1 ·d -1 ); Anshenwendan pill group (0.5 g·kg -1 ·d -1 ), melatonin group (0.1 g kg -1 ·d -1 ) and Chinese medicine composition groups I to IX (all 0.5 g·kg -1 ·d -1 )Give the corresponding medicine once a day for 7 consecutive days.

[0097] 7. Effect of experimental methods on sleep time of mice exposed to threshold dose of sodium pentobarbital

[0098] The model mice were injected with a threshold dose of sodium pentobarbital (50 mg / kg) intraperitoneally 1 hour after the last administration, and the number of animals that fell asleep within 30 minutes (those whose righting reflex disappeared for more than 1 minute) was recorded. The experiment should be carried out in a quiet environment at 24-25℃. Compared with the control group, the inter-group t test was used to test the significance of the difference.

[0099] 8 Statistical analysis

[0100] The experimental data were statistically analyzed using SPSS19.0 software, and the results were expressed as mean ± standard deviation. P < 0.05 was considered statistically significant.

[0101] 9. Results

[0102] The sleep time of mice in each group was compared. Compared with the blank group, the sleep time of mice in the model group increased (P < 0.05); compared with the model group, the sleep time of mice in the Anshen Wendan Pills group, Wendan Decoction preparation group, melatonin group and Chinese medicine combination groups I to IX decreased (P < 0.05), and the sleep time of Chinese medicine combination VII was significantly reduced compared with the Anshen Wendan Pills group, Wendan Decoction preparation group and melatonin group (P < 0.01). See the table for details.

[0103] Table 2 Sleep schedule for mice

[0104]

[0105] Note: Compared with the model group # p<0.05, ## p<0.01, ### p<0.001; compared with Anshen Wendan Pills group and Wendan Decoction group Δ p<0.05, ΔΔ p<0.01, ΔΔΔ p<0.05

[0106] Based on the above information, group VII of the present invention has obvious advantages in treating the insomnia model caused by liver depression and fire syndrome compared with the model group, Anshen Wendan pills group, Wendan decoction preparation group and melatonin group.

[0107] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating insomnia caused by liver depression and fire syndrome, characterized in that: It is composed of the following Chinese herbal medicine extracts in parts by weight: 1 part of Chinese herbal medicine extract A, 2 parts of Chinese herbal medicine extract B, 2 parts of Chinese herbal medicine extract C, 1 part of Chinese herbal medicine extract D; Alternatively, 1 part of Chinese herbal medicine extract A, 8 parts of Chinese herbal medicine extract B, 10 parts of Chinese herbal medicine extract C, and 2 parts of Chinese herbal medicine extract D; Alternatively, 1 part of Chinese herbal medicine extract A, 14 parts of Chinese herbal medicine extract B, 18 parts of Chinese herbal medicine extract C, and 3 parts of Chinese herbal medicine extract D; Alternatively, 5 parts of the Chinese herbal extract A, 2 parts of the Chinese herbal extract B, 18 parts of the Chinese herbal extract C, and 2 parts of the Chinese herbal extract D; The preparation method of Chinese medicine extract A comprises the following steps: Mixing the immature bitter orange, dried orange peel and water, extracting by steam distillation, and collecting volatile oil; the mass ratio of the immature bitter orange to the dried orange peel is 1:0.5-1.5; The volatile oil is mixed with β-cyclodextrin and water, passed through a colloid mill, and dried to obtain a Chinese medicine extract A; The preparation method of Chinese medicine extract B comprises the following steps: Extracting bamboo shavings and dried tangerine peel with ethanol aqueous solution combined with ultrasonic wave to obtain Chinese medicine extract B; the mass ratio of bamboo shavings to dried tangerine peel is 5:1-5; The preparation method of Chinese medicine extract C comprises the following steps: Mixing pinellia tuber, bamboo shavings, immature bitter orange, dried orange peel, liquorice and poria for water extraction to obtain Chinese medicine extract C; the mass ratio of pinellia tuber, bamboo shavings, immature bitter orange, dried orange peel, liquorice and poria is 2:1~5: 1~5:4~8:1~5:1~5; The preparation method of the Chinese medicine extract D comprises the following steps: Tangerine peel, licorice and Poria cocos were crushed to obtain a traditional Chinese medicine extract D, wherein the mass ratio of tangerine peel, licorice and Poria cocos was 3:1-5:0.3-0.

75.

2. The Chinese medicine composition according to claim 1, characterized in that: It is composed of the following Chinese herbal medicine extracts in parts by weight: The Chinese herbal extract A comprises 5 parts, the Chinese herbal extract B comprises 2 parts, the Chinese herbal extract C comprises 18 parts, and the Chinese herbal extract D comprises 2 parts.

3. The Chinese medicine composition according to claim 1, characterized in that In the preparation method of the Chinese medicine extract A, the mass ratio of the total mass of the immature bitter orange and the dried orange peel to water is 1:8-10; The mass ratio of the volatile oil, beta-cyclodextrin and water is 1:4-8:

1.

4. The Chinese medicine composition according to claim 1, characterized in that: In the preparation method of the Chinese medicine extract A, the extraction time by steam distillation is 3 to 7 hours.

5. The Chinese medicine composition according to claim 1, characterized in that: In the preparation method of the traditional Chinese medicine extract B, the volume percentage of the ethanol aqueous solution is 50-90%.

6. The Chinese medicine composition according to claim 1, characterized in that: In the preparation method of the traditional Chinese medicine extract B, the ultrasonic extraction time is 20 to 40 minutes.

7. The Chinese medicine composition according to claim 1, characterized in that: In the preparation method of Chinese medicine extract C, the water extraction adopts reflux extraction twice, and in the first reflux extraction, the mass ratio of the total mass of Pinellia tuber, Rhizoma Anemarrhenae, Immature Citrus Aurantium, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Poria cocos to water is 1:8-12, and the extraction time is 2-4h; During the second reflux extraction, the total mass ratio of Pinellia, Rhizoma Anemarrhenae, Immature Citrus aurantium, Citrus reticulatae, Radix Glycyrrhizae and Poria to water is 1:6-10, and the extraction time is 1-3h.

8. Use of the Chinese medicine composition according to any one of claims 1 to 7 in the preparation of a medicament for treating insomnia caused by liver depression and fire syndrome.

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