A composition for whitening and lightening spots and its use

Abstract

This invention belongs to the field of cosmetic technology and discloses a whitening and spot-fading composition and its application. The composition includes the following components: peony root bark extract, ethoxydiethylene glycol, sucrose dilaurate, carnosine, pea extract, nonapeptide-1, and niacinamide tetrapeptide-30. This invention combines these components, which have different mechanisms of action, to achieve synergistic effects through multi-pathway action, working together to target the skin from multiple dimensions and achieve effective and safe whitening and spot-fading effects.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, and specifically relates to a whitening and spot-fading composition and its application. Background Technology

[0002] With the improvement of living standards and the pursuit of beauty, more and more people desire to have fair and radiant skin, so the market demand for whitening and spot-fading products is growing.

[0003] Skin color is primarily determined by the amount of melanin in the skin. Melanin is a ubiquitous biological pigment, and its synthesis, transport, and metabolism within melanocytes are complex biochemical processes involving multiple enzymes. Sun exposure and aging often lead to brown spots on the skin, often due to overactive melanocytes secreting excessive melanin. The alpha-melanocyte-stimulating hormone (α-MSH) has a physiological effect on skin pigmentation. The binding of α-MSH to the specific receptor MC1-R on melanocytes activates tyrosinase, thereby stimulating the melanin synthesis pathway. Therefore, skin whitening requires addressing multiple aspects, including melanin synthesis, melanosome transport, metabolism, oxidative stress, and UV stimulation, to achieve the desired effect. The skin whitening mechanism mainly involves three aspects: inhibiting melanin synthesis, regulating melanin metabolic pathways, and promoting melanin metabolism, with the key being the inhibition of melanin synthesis and secretion.

[0004] There are many methods for skin whitening and fading dark spots, including using whitening products, undergoing cosmetic surgery, and using traditional Chinese medicine for beauty purposes. Clinically used whitening ingredients such as hydroquinone, kojic acid, etc., all have good ability to inhibit melanin production; however, these substances are irritating and cytotoxic, leading to adverse reactions such as allergies, pigmentation, and depigmentation. Therefore, developing gentler, safer, and more effective whitening and fading dark spots products is a technical challenge that urgently needs to be solved by those skilled in the art. Summary of the Invention

[0005] The present invention aims to at least solve one of the technical problems existing in the prior art. To this end, the present invention provides a whitening and spot-fading composition and its application. The composition, through the synergistic effect of multiple components, works on the skin from multiple dimensions, and has good whitening, spot-fading, and skin-brightening effects, while being gentle and safe.

[0006] A first aspect of the present invention provides a composition comprising the following components: peony root bark extract, ethoxydiethylene glycol, sucrose dilaurate, carnosine, pea extract, nonapeptide-1, and nicotinic tetrapeptide-30.

[0007] During their long-term production and research, the inventors delved into the active ingredients in cosmetic raw materials that have whitening and spot-fading effects. They unexpectedly discovered that a reasonable combination of peony root bark extract, ethoxydiethylene glycol, sucrose dilaurate, carnosine, pea extract, nonapeptide-1, and nicotinyl tetrapeptide-30 can exert a synergistic effect, resulting in good whitening, spot-fading, and skin-brightening effects. At the same time, the composition of this invention is mild and highly safe.

[0008] Specifically, in the composition of the present invention, the effects of each component are as follows:

[0009] Peony root bark mainly contains active ingredients such as paeonol, paeonol glycoside, volatile oil, and phytosterols. Among them, paeonol has sedative, soothing, and anti-inflammatory effects. Peony root bark can lower blood pressure; it also has analgesic, sedative, anti-inflammatory, and antipyretic effects; it has a strong inhibitory effect on various pathogenic bacteria; and it has a good effect on increasing skin smoothness, improving skin whitening, and shrinking pores.

[0010] Ethoxydiethylene glycol is a good moisturizer and solvent. Because it can cause temporary disarray in the arrangement of skin surface cells, it has good permeability and can promote the absorption of active ingredients.

[0011] Sucrose dilaurate can inhibit tyrosinase activity and reduce AGEs, thus achieving an anti-glycation effect. Pea extract can restore skin activity and elasticity, purify skin tone, repair scars, and has high moisturizing properties. The synergistic effect of sucrose dilaurate and pea extract effectively targets B16 melanocytes, significantly reducing melanin formation and lowering tyrosinase activity.

[0012] Carnosine has strong antioxidant and anti-glycation capabilities. It can scavenge reactive oxygen species (ROS) and α-β-unsaturated aldehydes generated during oxidative stress, and reduce the formation of advanced glycation end products (AGEs).

[0013] Nonapeptide-1 is a biomimetic peptide of natural α-MSH that competitively prevents the binding of the natural ligand α-MSH to the receptor MC1-R, thereby blocking the activity of tyrosinase, reducing melanin production, and preventing excessive melanin production.

[0014] Nicotinyl tetrapeptide-30, as a novel raw material, derives its amino acid series from short peptides in cephalosporin protein fragments. It promotes the production of type I collagen, and its activity is further enhanced after modification with nicotinic acid. Furthermore, nicotinic acid can be converted into nicotinamide in vivo. Type I collagen is a structural protein found in animals, a component of collagen fibers, accounting for 80% of collagen in adult dermis, and has moisturizing, spot-removing, and anti-aging effects. Enhanced amino acid activity signifies enhanced moisturizing, anti-wrinkle, and whitening effects. Nicotinamide, on the other hand, has antioxidant, whitening, and spot-removing effects on the skin, and inhibits the transfer of melanin to keratinocytes.

[0015] According to some embodiments of the present invention, the composition comprises the following components in parts by weight: 50-80 parts of peony root bark extract, 10-30 parts of ethoxydiethylene glycol, 1-20 parts of sucrose dilaurate, 0.1-5 parts of carnosine, 0.1-2 parts of pea extract, 0.01-1 part of nonapeptide-1, and 0.01-0.5 parts of nicotinic tetrapeptide-30.

[0016] According to some embodiments of the present invention, the composition comprises the following components in parts by weight: 70-80 parts of peony root bark extract, 10-15 parts of ethoxydiethylene glycol, 1-10 parts of sucrose dilaurate, 3-5 parts of carnosine, 0.1-1 parts of pea extract, 0.01-0.1 parts of nonapeptide-1, and 0.01-0.1 parts of nicotinic tetrapeptide-30.

[0017] According to some embodiments of the present invention, the composition comprises the following components in parts by weight: 50-60 parts of peony root bark extract, 20-30 parts of ethoxydiethylene glycol, 15-20 parts of sucrose dilaurate, 0.1-1 parts of carnosine, 1.5-2 parts of pea extract, 0.3-1 parts of nonapeptide-1, and 0.1-0.2 parts of nicotinic tetrapeptide-30.

[0018] According to some embodiments of the present invention, the composition comprises the following components in parts by weight: 60-70 parts of peony root bark extract, 15-20 parts of ethoxydiethylene glycol, 10-15 parts of sucrose dilaurate, 1-3 parts of carnosine, 1-1.5 parts of pea extract, 0.1-0.3 parts of nonapeptide-1, and 0.2-0.5 parts of nicotinic tetrapeptide-30.

[0019] According to some embodiments of the present invention, the peony root bark extract is peony (PAEONIA SUFFRUTICOSA) root water.

[0020] It is understood that the preparation method of the composition of the present invention is simply to mix the components evenly.

[0021] A second aspect of the invention provides the use of the compositions described herein in the preparation of cosmetics or topical skin preparations.

[0022] A third aspect of the present invention provides a cosmetic product comprising the composition described herein.

[0023] According to some embodiments of the present invention, the cosmetic also includes cosmetic-acceptable excipients.

[0024] According to some embodiments of the present invention, the excipients include at least one of oils, emulsifiers, polyols, thickeners, preservatives, and fragrances.

[0025] According to some embodiments of the present invention, the amount of the composition added to the cosmetic is 1 to 20 wt%.

[0026] According to some embodiments of the present invention, the composition is added to the cosmetic in an amount of 5 to 10 wt%.

[0027] According to some embodiments of the present invention, the cosmetic includes essence water, essence lotion, sheet mask or essence cream.

[0028] According to some embodiments of the present invention, the essence water comprises the following components: the composition described in this invention, 1,3-propanediol, butylene glycol, methylparaben, propylparaben, PEG-40 hydrogenated castor oil, fragrance, disodium EDTA, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, methyl gluceth-10, panthenol, allantoin, phenoxyethanol, and deionized water.

[0029] According to some embodiments of the present invention, the essence lotion comprises the following components: the composition described in this invention, glycerin, disodium EDTA, butylene glycol, sodium hyaluronate, betaine, carbomer, dimethicone, cetearyl alcohol, caprylic / capric triglyceride, shea butter, polysorbate-20, methylparaben, ethylparaben, phenoxyethanol, aminomethylpropanol, and deionized water.

[0030] According to some embodiments of the present invention, the face mask comprises the following components: the composition described in this invention, glycerin, allantoin, panthenol, sodium hyaluronate, hydroxyethyl cellulose, xanthan gum, carbomer, butylene glycol, p-hydroxyacetophenone, phenoxyethanol, aminomethylpropanol, and deionized oil.

[0031] According to some embodiments of the present invention, the essence cream comprises the following components: the composition described in this invention, glycerin, butylene glycol, sodium hyaluronate, panthenol, carbomer, glyceryl stearate / PEG-100 stearate, cetearyl alcohol, cyclopentamethoxysiloxane, caprylic / capric triglyceride, squalane, shea butter, cetyl ethylhexanoate, tocopheryl acetate, phenoxyethanol, aminomethylpropanol, and deionized water.

[0032] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0033] This invention combines peony root bark extract, ethoxydiethylene glycol, sucrose dilaurate, carnosine, pea extract, nonapeptide-1, and nicotinyl tetrapeptide-30, which have different mechanisms of action. Through the multi-pathway action of each component, they complement each other and synergistically enhance the effect, acting on the skin from multiple dimensions to achieve effective and safe whitening and spot-fading effects. Detailed Implementation

[0034] To enable those skilled in the art to more clearly understand the technical solutions described in this invention, the following embodiments are provided for illustration. It should be noted that the following embodiments do not constitute a limitation on the scope of protection claimed by this invention.

[0035] Unless otherwise specified, the raw materials, reagents or devices used in the following examples are available from conventional commercial sources or can be obtained by existing known methods.

[0036] Example 1

[0037] This embodiment provides a whitening and spot-fading composition, which consists of the following components in parts by weight: 62.98 parts of peony (PAEONIA SUFFRUTICOSA) root water, 10 parts of ethoxydiethylene glycol, 20 parts of sucrose dilaurate, 5 parts of carnosine, 2 parts of pea extract, 0.01 parts of nonapeptide-1, and 0.01 parts of nicotinic acid tetrapeptide-30.

[0038] Example 2

[0039] This embodiment provides a whitening and spot-fading composition, which consists of the following components in parts by weight: 57.8 parts of peony (PAEONIA SUFFRUTICOSA) root water, 30 parts of ethoxydiethylene glycol, 10 parts of sucrose dilaurate, 0.1 parts of carnosine, 1 part of pea extract, 1 part of nonapeptide-1, and 0.1 parts of nicotinic tetrapeptide-30.

[0040] Example 3

[0041] This embodiment provides a whitening and spot-fading composition, which consists of the following components in parts by weight: 75.3 parts of peony (PAEONIA SUFFRUTICOSA) root water, 20 parts of ethoxydiethylene glycol, 1 part of sucrose dilaurate, 3 parts of carnosine, 0.1 parts of pea extract, 0.1 parts of nonapeptide-1, and 0.5 parts of nicotinic tetrapeptide-30.

[0042] Example 4

[0043] This embodiment provides a whitening and spot-fading composition, which consists of the following components in parts by weight: 80 parts of peony (PAEONIA SUFFRUTICOSA) root water, 10 parts of ethoxydiethylene glycol, 7 parts of sucrose dilaurate, 2 parts of carnosine, 0.7 parts of pea extract, 0.2 parts of nonapeptide-1, and 0.1 parts of nicotinic tetrapeptide-30.

[0044] Example 5

[0045] This embodiment provides a whitening and spot-fading composition, which consists of the following components in parts by weight: 50 parts of peony (PAEONIA SUFFRUTICOSA) root water, 30 parts of ethoxydiethylene glycol, 15 parts of sucrose dilaurate, 3 parts of carnosine, 1.5 parts of pea extract, 0.3 parts of nonapeptide-1, and 0.2 parts of nicotinic acid tetrapeptide-30.

[0046] Example 6

[0047] This embodiment provides a whitening and spot-fading composition, which consists of the following components in parts by weight: 58.2 parts of peony (PAEONIA SUFFRUTICOSA) root water, 25 parts of ethoxydiethylene glycol, 10 parts of sucrose dilaurate, 5 parts of carnosine, 1 part of pea extract, 0.5 parts of nonapeptide-1, and 0.3 parts of nicotinic tetrapeptide-30.

[0048] Comparative Example 1

[0049] Compared to Example 6, in Comparative Example 1, the root water of peony (PAEONIA SUFFRUTICOSA) was replaced with deionized water, while other conditions were the same as in Example 6.

[0050] Comparative Example 2

[0051] Compared to Example 6, in Comparative Example 2, ethoxydiethylene glycol was replaced with deionized water, while other conditions were the same as in Example 6.

[0052] Comparative Example 3

[0053] Compared to Example 6, in Comparative Example 3, sucrose dilaurate was replaced with deionized water, while other conditions were the same as in Example 6.

[0054] Comparative Example 4

[0055] Compared to Example 6, in Comparative Example 4, carnosine was replaced with deionized water, and other conditions were the same as in Example 6.

[0056] Comparative Example 5

[0057] Compared to Example 6, in Comparative Example 5, the pea extract was replaced with deionized water, while other conditions were the same as in Example 6.

[0058] Comparative Example 6

[0059] Compared with Example 6, in Comparative Example 6, nonapeptide-1 was replaced with deionized water, and other conditions were the same as in Example 6.

[0060] Comparative Example 7

[0061] Compared to Example 6, in Comparative Example 7, nicotinic tetrapeptide-30 was replaced with deionized water, while other conditions were the same as in Example 6.

[0062] Comparative Example 8

[0063] Compared with Example 6, in Comparative Example 8, the root water of peony (PAEONIA SUFFRUTICOSA) and sucrose dilaurate were replaced with deionized water, and other conditions were the same as in Example 6.

[0064] Comparative Example 9

[0065] Compared with Example 6, in Comparative Example 9, the root water of peony (PAEONIA SUFFRUTICOSA) and carnosine were replaced with deionized water, and other conditions were the same as in Example 6.

[0066] Comparative Example 10

[0067] Compared with Example 6, in Comparative Example 10, the root water of peony (PAEONIA SUFFRUTICOSA) and pea extract were replaced with deionized water, and other conditions were the same as in Example 6.

[0068] Comparative Example 11

[0069] Compared with Example 6, in Comparative Example 11, the root water of peony (PAEONIA SUFFRUTICOSA) and nonapeptide-1 were replaced with deionized water, and other conditions were the same as in Example 6.

[0070] Comparative Example 12

[0071] Compared with Example 6, in Comparative Example 12, the root water of peony (PAEONIA SUFFRUTICOSA) and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0072] Comparative Example 13

[0073] Compared with Example 6, in Comparative Example 13, sucrose dilaurate and carnosine were replaced with deionized water, and other conditions were the same as in Example 6.

[0074] Comparative Example 14

[0075] Compared with Example 6, in Comparative Example 14, sucrose dilaurate and pea extract were replaced with deionized water, while other conditions were the same as in Example 6.

[0076] Comparative Example 15

[0077] Compared with Example 6, in Comparative Example 15, sucrose dilaurate and nonapeptide-1 were replaced with deionized water, and other conditions were the same as in Example 6.

[0078] Comparative Example 16

[0079] Compared with Example 6, in Comparative Example 16, sucrose dilaurate and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0080] Comparative Example 17

[0081] Compared with Example 6, in Comparative Example 17, carnosine and pea extract were replaced with deionized water, and other conditions were the same as in Example 6.

[0082] Comparative Example 18

[0083] Compared with Example 6, in Comparative Example 18, carnosine and nonapeptide-1 were replaced with deionized water, and other conditions were the same as in Example 6.

[0084] Comparative Example 19

[0085] Compared with Example 6, in Comparative Example 19, carnosine and nicotinic tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0086] Comparative Example 20

[0087] Compared with Example 6, in Comparative Example 20, pea extract and nonapeptide-1 were replaced with deionized water, and other conditions were the same as in Example 6.

[0088] Comparative Example 21

[0089] Compared with Example 6, in Comparative Example 21, pea extract peptides and nicotinic tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0090] Comparative Example 22

[0091] Compared with Example 6, in Comparative Example 22, nonapeptide-1 and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0092] Comparative Example 23

[0093] Compared with Example 6, in Comparative Example 23, the root water of peony (PAEONIA SUFFRUTICOSA), sucrose dilaurate, and carnosine were replaced with deionized water, while other conditions were the same as in Example 6.

[0094] Comparative Example 24

[0095] Compared to Example 6, in Comparative Example 24, peony root water, sucrose dilaurate, and pea extract were replaced with deionized water, while other conditions were the same as in Example 6.

[0096] Comparative Example 25

[0097] Compared with Example 6, in Comparative Example 25, the root water of peony (PAEONIA SUFFRUTICOSA), sucrose dilaurate, and nonapeptide-1 were replaced with deionized water, and other conditions were the same as in Example 6.

[0098] Comparative Example 26

[0099] Compared with Example 6, in Comparative Example 26, the root water of peony (PAEONIA SUFFRUTICOSA), sucrose dilaurate, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0100] Comparative Example 27

[0101] Compared with Example 6, in Comparative Example 27, the root water of peony (PAEONIA SUFFRUTICOSA), carnosine, and pea extract were replaced with deionized water, while other conditions were the same as in Example 6.

[0102] Comparative Example 28

[0103] Compared with Example 6, in Comparative Example 28, the root water of peony (PAEONIA SUFFRUTICOSA), carnosine, and nonapeptide-1 were replaced with deionized water, and other conditions were the same as in Example 6.

[0104] Comparative Example 29

[0105] Compared with Example 6, in Comparative Example 29, the root water of peony (PAEONIA SUFFRUTICOSA), carnosine, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0106] Comparative Example 30

[0107] Compared with Example 6, in Comparative Example 30, the root water of peony (PAEONIA SUFFRUTICOSA), pea extract, and nonapeptide-1 were replaced with deionized water, while other conditions were the same as in Example 6.

[0108] Comparative Example 31

[0109] Compared with Example 6, in Comparative Example 31, the root water of peony (PAEONIA SUFFRUTICOSA), pea extract, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0110] Comparative Example 32

[0111] Compared with Example 6, in Comparative Example 32, the root water of peony (PAEONIA SUFFRUTICOSA), nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0112] Comparative Example 33

[0113] Compared with Example 6, in Comparative Example 33, sucrose dilaurate, carnosine, and pea extract were replaced with deionized water, while other conditions were the same as in Example 6.

[0114] Comparative Example 34

[0115] Compared with Example 6, in Comparative Example 34, sucrose dilaurate, carnosine, and nonapeptide-1 were replaced with deionized water, and other conditions were the same as in Example 6.

[0116] Comparative Example 35

[0117] Compared with Example 6, in Comparative Example 35, sucrose dilaurate, carnosine, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0118] Comparative Example 36

[0119] Compared with Example 6, in Comparative Example 36, sucrose dilaurate, pea extract, and nonapeptide-1 were replaced with deionized water, while other conditions were the same as in Example 6.

[0120] Comparative Example 37

[0121] Compared with Example 6, in Comparative Example 37, sucrose dilaurate, pea extract, and nicotinyl tetrapeptide-30 were replaced with deionized water, while other conditions were the same as in Example 6.

[0122] Comparative Example 38

[0123] Compared with Example 6, in Comparative Example 38, sucrose dilaurate, nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0124] Comparative Example 39

[0125] Compared with Example 6, in Comparative Example 39, carnosine, pea extract, and nonapeptide-1 were replaced with deionized water, while other conditions were the same as in Example 6.

[0126] Comparative Example 40

[0127] Compared with Example 6, in Comparative Example 40, carnosine, pea extract, and nicotinyl tetrapeptide-30 were replaced with deionized water, while other conditions were the same as in Example 6.

[0128] Comparative Example 41

[0129] Compared with Example 6, in Comparative Example 41, carnosine, nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0130] Comparative Example 42

[0131] Compared with Example 6, in Comparative Example 42, pea extract, nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0132] Comparative Example 43

[0133] Compared with Example 6, in Comparative Example 43, the root water of peony (PAEONIA SUFFRUTICOSA), sucrose dilaurate, carnosine, and pea extract were replaced with deionized water, while other conditions were the same as in Example 6.

[0134] Comparative Example 44

[0135] Compared with Example 6, in Comparative Example 44, the root water of peony (PAEONIA SUFFRUTICOSA), sucrose dilaurate, carnosine, and nonapeptide-1 were replaced with deionized water, and other conditions were the same as in Example 6.

[0136] Comparative Example 45

[0137] Compared with Example 6, in Comparative Example 45, the root water of peony (PAEONIA SUFFRUTICOSA), sucrose dilaurate, carnosine, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0138] Comparative Example 46

[0139] Compared with Example 6, in Comparative Example 46, the root water of peony (PAEONIA SUFFRUTICOSA), sucrose dilaurate, pea extract, and nonapeptide-1 were replaced with deionized water, and other conditions were the same as in Example 6.

[0140] Comparative Example 47

[0141] Compared to Example 6, in Comparative Example 47, peony root water, sucrose dilaurate, pea extract, and nicotinyl tetrapeptide-30 were replaced with deionized water, while other conditions were the same as in Example 6.

[0142] Comparative Example 48

[0143] Compared with Example 6, in Comparative Example 48, the root water of peony (PAEONIA SUFFRUTICOSA), sucrose dilaurate, nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0144] Comparative Example 49

[0145] Compared with Example 6, in Comparative Example 49, the root water of peony (PAEONIA SUFFRUTICOSA), carnosine, pea extract, and nonapeptide-10 were replaced with deionized water, and other conditions were the same as in Example 6.

[0146] Comparative Example 50

[0147] Compared with Example 6, in Comparative Example 50, the root water of peony (PAEONIA SUFFRUTICOSA), carnosine, pea extract, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0148] Comparative Example 51

[0149] Compared with Example 6, in Comparative Example 51, the root water of peony (PAEONIA SUFFRUTICOSA), carnosine, nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0150] Comparative Example 52

[0151] Compared with Example 6, in Comparative Example 52, the root water of peony (PAEONIA SUFFRUTICOSA), pea extract, nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0152] Comparative Example 53

[0153] Compared with Example 6, in Comparative Example 53, sucrose dilaurate, carnosine, pea extract, and nonapeptide-1 were replaced with deionized water, while other conditions were the same as in Example 6.

[0154] Comparative Example 54

[0155] Compared with Example 6, in Comparative Example 54, sucrose dilaurate, carnosine, pea extract, and nicotinyl tetrapeptide-30 were replaced with deionized water, while other conditions were the same as in Example 6.

[0156] Comparative Example 55

[0157] Compared with Example 6, in Comparative Example 55, sucrose dilaurate, carnosine, nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0158] Comparative Example 56

[0159] Compared with Example 6, in Comparative Example 56, sucrose dilaurate, pea extract, nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0160] Comparative Example 57

[0161] Compared with Example 6, in Comparative Example 57, carnosine, pea extract, nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0162] Comparative Example 58

[0163] Compared with Example 6, in Comparative Example 58, peony root water, sucrose dilaurate, carnosine, pea extract, and nonapeptide-1 were replaced with deionized water, while other conditions were the same as in Example 6.

[0164] Comparative Example 59

[0165] Compared with Example 6, in Comparative Example 59, peony root water, sucrose dilaurate, carnosine, pea extract, and nicotinyl tetrapeptide-30 were replaced with deionized water, while other conditions were the same as in Example 6.

[0166] Comparative Example 60

[0167] Compared with Example 6, in Comparative Example 60, the root water of peony (PAEONIA SUFFRUTICOSA), sucrose dilaurate, carnosine, nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0168] Comparative Example 61

[0169] Compared with Example 6, in Comparative Example 61, the root water of peony (PAEONIA SUFFRUTICOSA), sucrose dilaurate, pea extract, nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0170] Comparative Example 62

[0171] Compared with Example 6, in Comparative Example 62, the root water of peony (PAEONIA SUFFRUTICOSA), carnosine, pea extract, nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0172] Comparative Example 63

[0173] Compared with Example 6, in Comparative Example 63, sucrose dilaurate, carnosine, pea extract, nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, and other conditions were the same as in Example 6.

[0174] Comparative Example 64

[0175] Compared with Example 6, in Comparative Example 64, peony root water, sucrose dilaurate, carnosine, pea extract, nonapeptide-1, and nicotinyl tetrapeptide-30 were replaced with deionized water, while other conditions were the same as in Example 6.

[0176] Comparative Example 65

[0177] Compared to Example 6, in Comparative Example 65, the root water of peony (PAEONIA SUFFRUTICOSA) was replaced with peony flower water, and other conditions were the same as in Example 6.

[0178] Comparative Example 66

[0179] Compared to Example 6, in Comparative Example 66, ethoxydiethylene glycol was replaced with glycerol, and all other conditions were the same as in Example 6.

[0180] Comparative Example 67

[0181] Compared to Example 6, in Comparative Example 67, sucrose dilaurate was replaced with sucrose distearate, and all other conditions were the same as in Example 6.

[0182] Comparative Example 68

[0183] Compared to Example 6, in Comparative Example 68, carnosine was replaced with bosine, and other conditions were the same as in Example 6.

[0184] Comparative Example 69

[0185] Compared to Example 6, in Comparative Example 69, the pea extract was replaced with hydrolyzed pea protein, and all other conditions were the same as in Example 6.

[0186] Comparative Example 70

[0187] Compared to Example 6, in Comparative Example 70, nonapeptide-1 was replaced with hexapeptide-2, and other conditions were the same as in Example 6.

[0188] Comparative Example 71

[0189] Compared to Example 6, in Comparative Example 71, nicotinic acid tetrapeptide-30 was replaced with tetrapeptide-30, and other conditions were the same as in Example 6.

[0190] Comparative Example 72

[0191] Compared to Example 6, in Comparative Example 72, nicotinic acid tetrapeptide-30 was replaced with nicotinamide, and other conditions were the same as in Example 6.

[0192] Application Example 1

[0193] A whitening and spot-fading essence water, the specific formula of which is shown in Table 1.

[0194] Table 1 Formula Table

[0195]

[0196]

[0197] The preparation method of this whitening and spot-fading essence water includes the following steps:

[0198] (1) Dissolve the A phase raw material at 65°C until it becomes transparent, and then cool it down to below 40°C;

[0199] (2) Pre-disperse the B phase raw material evenly and completely;

[0200] (3) Mix and stir the C phase raw material evenly, and then add the A phase raw material treated in step (1) and the B phase raw material treated in step (2) into the C phase raw material and stir until evenly dispersed;

[0201] (4) After passing the inspection, filter the material through a 300-mesh filter.

[0202] Application Example 2

[0203] A whitening and spot-fading essence lotion, the specific formula of which is shown in Table 2.

[0204] Table 2 Formula Table

[0205]

[0206] The preparation method of this whitening and spot-fading essence includes the following steps:

[0207] (1) Add phase A raw material into the emulsifying pot, stir and disperse it evenly, and heat it to 80℃;

[0208] (2) Add the B phase raw material to the oil phase pot, heat it to 80°C to dissolve and disperse it evenly, and then slowly pump the B phase raw material into the emulsification pot of step (1) and homogenize and emulsify for 15 minutes.

[0209] (3) After the mixture in the emulsifying pot of step (2) has cooled down to 45°C, add the C phase raw material into the emulsifying pot and stir to disperse it evenly.

[0210] (4) After passing the inspection, filter the material through a 300-mesh filter.

[0211] Application Example 3

[0212] A whitening and spot-fading facial mask, the specific formula of which is shown in Table 3.

[0213] Table 3 Formula Table

[0214]

[0215] The preparation method of this whitening and spot-fading facial mask includes the following steps:

[0216] (1) Add phase A raw material into the emulsifying pot, stir and disperse it evenly, and heat it to 80℃;

[0217] (2) Preheat and dissolve the B phase raw material;

[0218] (3) After the emulsifying pot of step (1) is cooled to 45°C, the B phase raw material and C phase raw material after step (2) are put into the emulsifying pot and stirred and dispersed evenly.

[0219] (4) After passing the inspection, filter the material through a 300-mesh filter.

[0220] Application Example 4

[0221] A whitening and spot-fading essence face cream, the specific formula of which is shown in Table 4.

[0222] Table 4 Formula Table

[0223]

[0224]

[0225] Application Example 5

[0226] Compared to Application Example 1, in Application Example 5, the composition prepared in Example 6 was replaced with the composition prepared in Example 1, and all other conditions were the same as in Application Example 1.

[0227] Application Example 6

[0228] Compared to Application Example 1, in Application Example 6 the composition prepared in Example 6 was replaced with the composition prepared in Example 2, and all other conditions were the same as in Application Example 1.

[0229] Application Example 7

[0230] Compared to Application Example 1, in Application Example 7, the composition prepared in Example 6 was replaced with the composition prepared in Example 3, and all other conditions were the same as in Application Example 1.

[0231] Application Example 8

[0232] Compared to Application Example 1, in Application Example 8, the composition prepared in Example 6 was replaced with the composition prepared in Example 4, and all other conditions were the same as in Application Example 1.

[0233] Application Example 9

[0234] Compared to Application Example 1, in Application Example 9 the composition prepared in Example 6 was replaced with the composition prepared in Example 5, and all other conditions were the same as in Application Example 1.

[0235] Comparative Application Example 1

[0236] Compared to Application Example 1, in Comparative Application Example 1, the composition prepared in Example 6 was replaced with the composition prepared in Comparative Example 1, and all other conditions were the same as in Application Example 1.

[0237] Comparative Application Example 2

[0238] Compared to Application Example 1, in Comparative Application Example 2, the composition prepared in Example 6 was replaced with the composition prepared in Comparative Example 2, and all other conditions were the same as in Application Example 1.

[0239] Comparative Application Example 3

[0240] Compared to Application Example 1, in Comparative Application Example 3, the composition prepared in Example 6 was replaced with the composition prepared in Comparative Example 3, and all other conditions were the same as in Application Example 1.

[0241] Comparative Application Example 4

[0242] Compared to Application Example 1, in Comparative Application Example 4, the composition prepared in Example 6 was replaced with the composition prepared in Comparative Example 4, and all other conditions were the same as in Application Example 1.

[0243] Comparative Application Example 5

[0244] Compared to Application Example 1, in Comparative Application Example 5, the composition prepared in Example 6 was replaced with the composition prepared in Comparative Example 5, and all other conditions were the same as in Application Example 1.

[0245] Comparative Application Example 6

[0246] Compared to Application Example 1, in Comparative Application Example 6, the composition prepared in Example 6 was replaced with the composition prepared in Comparative Example 6, and all other conditions were the same as in Application Example 1.

[0247] Comparative Application Example 7

[0248] Compared to Application Example 1, in Comparative Application Example 7, the composition prepared in Example 6 was replaced with the composition prepared in Comparative Example 7, and all other conditions were the same as in Application Example 1.

[0249] Comparative Application Example 8

[0250] Compared to Application Example 1, in Comparative Application Example 8, the composition prepared in Example 6 was replaced with deionized water, while other conditions were the same as in Application Example 1.

[0251] Experimental Example 1: Free Radical Scavenging Test

[0252] The compositions prepared in Examples 1-6 and Comparative Examples 1-72 were respectively formulated into sample solutions and subjected to the following tests:

[0253] (1) Evaluation test of superoxide anion free radical scavenging ability

[0254] Take 4.5 mL of 0.05 mol / L Tris-HCl buffer solution (pH 8.2) and preheat it in a 25°C water bath for 30 min. Then add 1 mL of the sample solution and 0.4 mL of 25 mol / L pyrogallol solution, mix well, and react in a 25°C water bath for 5 min. Stop the reaction by adding 1 mL of 8 mol / L HCl. Measure the absorbance at 299 nm using the Tris-HCl buffer solution as a reference. The blank control group uses 1 mL of the sample solution as the solvent, and 120 μM Trolox is used as a positive control.

[0255] The formula for calculating the superoxide anion radical scavenging rate is shown below:

[0256] Superoxide anion radical scavenging rate (%) = [1 - (A2 / A1)] × 100%;

[0257] In the formula, A1 is the absorbance value of the blank control group, and A2 is the absorbance value of the sample group. The experimental results are shown in Table 5.

[0258] (2) Evaluation test of hydroxyl radical scavenging ability

[0259] Add 3 mL of 2 mmol / L FeSO4 and 3 mL of 1 mmol / L H2O2 to a 25 mL cuvette, shake well, then add 3 mL of 6 mmol / L salicylic acid, shake well, heat in a 37 °C water bath for 15 min, and measure the absorbance. Add a certain concentration of sample solution, shake well, continue heating in a water bath for 15 min, and measure the absorbance. Use 120 μM Trolox as a positive control.

[0260] The formula for calculating the hydroxyl radical scavenging rate is shown below:

[0261] Hydroxyl radical scavenging rate (%) = [A0 - A x -(A0-A x0 )] / A0×100%;

[0262] In the formula, A0, A x A x0 The absorbance values ​​are shown in Table 5: absorbance of the reaction system before adding the sample, absorbance of the system after the sample has scavenged hydroxyl radicals, and absorbance of the system after the sample solvent has scavenged hydroxyl radicals. The experimental results are shown in Table 5.

[0263] (3) ABTS method for detecting the antioxidant activity of active components

[0264] The method for detecting antioxidant activity using the ABTS assay, as described in the reference, is briefly outlined below: Dilute the ABTS solution with deionized water to achieve an absorbance of 0.7 ± 0.02 at 734 nm, obtaining the ABTS working solution. Add 10 μL of the sample and 190 μL of the ABTS working solution to each well of a 96-well plate, and react at room temperature for 15 min. Repeat the reaction three times for each sample. Measure the absorbance at 734 nm using a microplate reader. Use 120 μM Trolox as a positive control. The scavenging rate is calculated using the following formula:

[0265] Sweep rate = (1-A) 样品 / 0.7)×100%;

[0266] In the formula, A 样品 The absorbance of the sample group is shown in Table 5. The experimental results are shown in Table 5.

[0267] Table 5 Results of Free Radical Scavenging Test

[0268]

[0269]

[0270]

[0271] In vitro evaluation of the antioxidant activity of whitening ingredients is an important method for studying whitening ingredients. Superoxide anion radical scavenging rate, hydroxyl radical scavenging rate, and ABTS radical scavenging rate are commonly used in vitro methods for evaluating antioxidant capacity. Higher scavenging rates indicate better antioxidant properties and a relatively better whitening effect. Therefore, the anti-aging effect can be judged by studying the composition's ability to scavenge free radicals. As shown in Table 5, compared with the comparative examples, the superoxide anion radical scavenging rate and hydroxyl radical scavenging rate of the examples are higher. Comparison of Example 6 with Comparative Examples 58-64 shows that the composition has better antioxidant capacity than a single component and is higher than the simple sum of the antioxidant capacities of several components, indicating a synergistic effect among the components and a reasonable compositional combination. This further demonstrates that the composition of the present invention has excellent antioxidant capacity. The comparison of Example 6 with Comparative Examples 65-72 shows that the components in the composition of the present invention have a synergistic effect; none can be omitted, and replacing them with similar active ingredients cannot achieve the effect of the composition of the present invention.

[0272] Experimental Example 2: Inhibition of Tyrosinase Activity and Inhibition of Intracellular Melanin Synthesis

[0273] 2.1 Inhibition of tyrosinase activity

[0274] 2.1.1 Experimental Objective

[0275] By comparing the whitening ingredient arbutin, commonly used in skincare products, the inhibitory effect of different concentrations of the composition on tyrosinase activity was tested, thereby examining the whitening effect of the composition of the present invention.

[0276] 2.1.2 Preparation of Reference Standard

[0277] Prepare a 1% (w / w) arbutin solution.

[0278] The compositions prepared in Examples 1-6 and Comparative Examples 1-72 were diluted to three concentrations of 5%, 1%, and 0.05%, respectively.

[0279] 2.1.3 Experimental Methods

[0280] Human epidermal melanocytes in the logarithmic growth phase were digested with trypsin / EDTA solution using an in vitro DOPA oxidation reaction method, and the reaction was terminated with trypsin neutralization solution. After centrifugation, the melanocytes were diluted to 1×10⁶ cells / mL with MelM medium. 5 The diluted liquid was inoculated at a density of 100 μL / well in a 96-well plate, with a seeding density of 10-1. 4 Cells / well. Incubate overnight until cells adhere, aspirate the culture medium, and add 100 μL of three gradient combination solutions to each well of a 96-well plate, with three replicates for each concentration. Establish a positive control group (melanocytes + melanocyte culture medium + 1% arbutin, 100 μL), a negative control group (melanocytes + melanocyte culture medium), and a blank control group (melanocyte culture medium only), with three replicates for each group. Incubate the 24-well plate at 37°C in a 5% CO2 incubator for 72 h. After drug treatment, discard the supernatant and wash the melanocytes 2-3 times with PBS. Add 100 μL of 1% Triton X-100 (prepared with PBS) to each well, and shake at low speed for 30 min. Place the 96-well plate at -20°C for 1 h, then allow it to thaw at room temperature to ensure complete melanin lysis. Add 100 μL of 0.1% L-DOPA (prepared with PBS) solution to each well and incubate at 37°C for 2 hours. Measure the absorbance of the sample using a microplate reader at a wavelength of 490 nm.

[0281] The relative inhibition rate of tyrosinase activity = (1 - [(average absorbance of the drug group - average absorbance of the blank group) / (average absorbance of the negative control group - average absorbance of the blank group)]) × 100%.

[0282] 2.2 Intracellular melanin production inhibition assay

[0283] B16 melanocytes were divided into 10×10 4Cells were seeded at a density of 3 mL / mL in 6-well plates. After incubation for 24 h, the supernatant was discarded, and the test samples were added at concentrations of 5%, 1%, and 0.05%. After 3 days of incubation, the supernatant was discarded, and the cells were washed with PBS. 0.5 mL of trypsin was added to each well to digest the cells, and 2 mL of culture medium was added to stop the digestion. The cells in each group were counted. The cell suspension was centrifuged and the supernatant was discarded to obtain the precipitate. Then, 1 mol / L NaOH solution containing 10% DMSO was added, and the mixture was shaken for 5 min. The absorbance of each sample was measured at 490 nm using a microplate reader. The formula for calculating the melanin synthesis inhibition rate is as follows:

[0284] Melanin synthesis inhibition rate (%) = [1 – (absorbance value of sample well / number of cells in sample well) / (absorbance value of control well / number of cells in control well)] × 100%.

[0285] 2.3 Experimental Results

[0286] The results of the tyrosinase activity inhibition test and the melanin production inhibition test are shown in Table 6.

[0287] Table 6 Results of Tyrosinase Activity Inhibition Test and Melanin Production Inhibition Test

[0288]

[0289]

[0290]

[0291] As can be seen from the data in Table 6, compared with the negative control group, the positive control group, the examples, and the comparative examples all showed inhibitory effects on tyrosinase activity and melanin production. Comparing the experimental results of the examples and the comparative examples, the compositions prepared in the examples showed higher relative inhibition rates of tyrosinase activity and melanin production. Comparing Example 6 with Comparative Examples 58-63, the inhibitory effect of the composition of the present invention on tyrosinase activity and melanin production is significantly better than that of a single component, indicating that the components in the composition of the present invention can have a synergistic effect. Comparing Example 6 with Comparative Examples 65-72, it can be seen that the inhibitory effect of Example 6 on tyrosinase activity and melanin production is significantly better than that of Comparative Examples 65-72, indicating that the components in the composition of the present invention have a synergistic effect, and none can be omitted; replacing them with similar active ingredients would not achieve the effect of the composition of the present invention.

[0292] Experimental Example 3: Red Blood Cell Hemolysis Test

[0293] The red blood cell hemolysis test (RBC) is an alternative to the rabbit eye irritation test (Draize test). Its basic principle is to evaluate the damage of chemicals to eye tissue cells by measuring the amount of hemoglobin dissolved and the degree of denaturation. Internationally, the RBC test is mainly used to evaluate the eye irritation of chemicals in cosmetics and raw materials.

[0294] Table 7 ECVAM Cosmetic Product RBC Irritation Grading Standards

[0295] L / D Classification L / D > 100 Non-irritating 10<L / D≤100 Mild irritation 1<L / D≤10 Mild irritation 0.1<L / D≤1 moderate irritation L / D≤0.1 Severe irritation

[0296] The results of the hemolysis test of the composition are shown in Table 8, where HD50 is the sample concentration when 50% of red blood cells are hemolyzed, DI is the protein denaturation index, and L / D is the ratio of HD50 to DI.

[0297] Table 8 Results of the Red Blood Cell Hemolysis Test

[0298] Experimental Project HD50 (mg / L) DI (%) L / D Example 1 244000 0.47 ﹥100 Example 2 218000 0.53 ﹥100 Example 3 193000 0.72 ﹥100 Example 4 330000 0.49 ﹥100 Example 5 267000 0.67 ﹥100 Example 6 235000 0.46 ﹥100 Comparative Example 1 186000 0.58 ﹥100 Comparative Example 2 357000 0.54 ﹥100 Comparative Example 3 207000 0.69 ﹥100 Comparative Example 4 198000 0.65 ﹥100 Comparative Example 5 218000 0.71 ﹥100 Comparative Example 6 247000 0.68 ﹥100 Comparative Example 7 264000 0.79 ﹥100

[0299] As can be seen from the test results in Table 8, the L / D values ​​of the compositions in both the examples and the comparative examples are greater than 100, indicating that the irritation level of the compositions is non-irritating. Furthermore, the compositions only cause hemolysis of red blood cells at higher concentrations, indicating that the compositions have mild and non-irritating characteristics.

[0300] Test Example 4: Stimulation Test

[0301] The irritation level of the product was further confirmed by analyzing the mildness sample data of different application examples and the main control application examples through irritation rating analysis. 390 consumers were selected and divided into 13 groups. Irritation ratings were given for products prepared in application examples 1-6 and control application examples 1-7 at the start of use and 3 days after use, respectively. The irritation rating rule was a 5-point scale: 1 point - mild irritation, 2 points - mild to moderate irritation, 3 points - moderate irritation, 4 points - moderate to severe irritation, and 5 points - severe irritation. Detailed statistical results are shown in Table 9.

[0302] Table 9. Results of Product Mildness Test

[0303]

[0304]

[0305] As can be seen from the irritation test data in Table 9, the products prepared in the application examples and the control application examples have lower irritation and better overall mildness, and can be used for subsequent human efficacy testing.

[0306] Experiment Example 5: Human Trial Evaluation of Whitening and Spot-Fading Products

[0307] Samples: Products prepared for Application Examples 1-9 and Comparative Application Examples 1-8.

[0308] Five hundred and ten subjects (healthy, with normal skin, no history of cosmetic allergies, aged 35-45 years) were selected and randomly divided into 17 groups. Each subject used the sample twice daily (one tablet per night, as in Example 3, due to the special dosage form), with a dosage of 0.5g each time, for 28 consecutive days. On days 14, 21, and 28, the subjects sat still for 30 minutes in a test environment of 20±2℃ and 50±10% humidity, and their facial skin ITA° color and melanin MI value were measured. Increased ITA° color indicated increased skin brightness; decreased melanin MI value indicated reduced skin darkening and whitening. Specific statistical results are shown in Table 10. The data in the table are averages.

[0309] Table 10 Results of Human Trial Evaluation

[0310]

[0311]

[0312] *P<0.05

[0313] As can be seen from the test results in Table 10, after 28 days of testing, the subjects using the application examples showed better improvement in melanin MI value and ITA° color than the control application examples. Application examples 1-4 all showed significant whitening effects compared to control application example 8, indicating that the base of the cosmetic does not affect the effect of the composition of the present invention, demonstrating that the composition of the present invention has a whitening and spot-fading effect. Among them, the melanin MI value of application example 1 decreased by 15.62% and the skin ITA° color increased by 7.32% after 28 days, while the corresponding values ​​of the control application example only increased by a maximum of 8.46% and 4.23% respectively, which further verifies that the composition of the present invention has good whitening and spot-fading ability.

[0314] The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the embodiments described. Those skilled in the art can make various equivalent modifications or substitutions without departing from the spirit of the present invention, and these equivalent modifications or substitutions are all included within the scope defined by the claims of this application.

Claims

1. A composition, characterized in that, The composition comprises the following components in parts by weight: 50-80 parts of peony root bark extract, 10-30 parts of ethoxydiethylene glycol, 1-20 parts of sucrose dilaurate, 0.1-5 parts of carnosine, 0.1-2 parts of pea extract, 0.01-1 part of nonapeptide-1, and 0.01-0.5 parts of nicotinic tetrapeptide-30.

2. The composition according to claim 1, characterized in that, The composition comprises the following components in parts by weight: 70-80 parts of peony root bark extract, 10-15 parts of ethoxydiethylene glycol, 1-10 parts of sucrose dilaurate, 3-5 parts of carnosine, 0.1-1 parts of pea extract, 0.01-0.1 parts of nonapeptide-1, and 0.01-0.1 parts of nicotinic tetrapeptide-30.

3. The composition according to claim 1, characterized in that, The composition comprises the following components in parts by weight: 50-60 parts of peony root bark extract, 20-30 parts of ethoxydiethylene glycol, 15-20 parts of sucrose dilaurate, 0.1-1 parts of carnosine, 1.5-2 parts of pea extract, 0.3-1 parts of nonapeptide-1, and 0.1-0.2 parts of nicotinic tetrapeptide-30.

4. The composition according to claim 1, characterized in that, The composition comprises the following components in parts by weight: 60-70 parts of peony root bark extract, 15-20 parts of ethoxydiethylene glycol, 10-15 parts of sucrose dilaurate, 1-3 parts of carnosine, 1-1.5 parts of pea extract, 0.1-0.3 parts of nonapeptide-1, and 0.2-0.5 parts of nicotinic tetrapeptide-30.

5. Use of the composition according to any one of claims 1 to 4 in the preparation of cosmetics or topical skin preparations.

6. A cosmetic product, characterized in that, Includes the composition according to any one of claims 1 to 4.

7. The cosmetic product according to claim 6, characterized in that, The composition is added to the cosmetic at an amount of 1-20 wt%.

8. The cosmetic product according to claim 7, characterized in that, The composition is added to the cosmetic at an amount of 5-10 wt%.

9. The cosmetic product according to claim 6, characterized in that, The cosmetics include essence water, essence lotion, sheet mask or essence cream.

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