Bactericidal compositions and their use

Abstract

The present application belongs to the field of agricultural fungicides, and particularly relates to a fungicidal composition and application thereof.The composition comprises two active components A and B, the weight ratio of the active component A to the active component B is 1:99-99:1; the active component A is one or more of substituted pyrazole compounds containing pyrimidine or salts thereof, and the active component B is selected from one fungicide.The fungicidal composition is particularly suitable for preventing and treating various plant pathogenic fungi and bacterial diseases.

Description

[0001] The present application is a further divisional application of 202210553242.8 of Chinese invention patent 202011314120.0; the application date of Chinese invention patent 202011314120.0 is November 20, 2020, the invention name is: fungicidal composition and its application, the publication number is: CN112825859A, the publication number of Chinese invention patent 202210553242.8 is: CN114903046A; due to the single problem pointed out by the examiner in the application of Chinese invention patent 202210553242.8, the applicant further proposes a divisional application for Chinese invention patent 202210553242.8. TECHNICAL FIELD

[0002] The present application belongs to the field of agricultural fungicides, and specifically relates to a fungicidal composition of a substituted pyrazole compound containing pyrimidine and a fungicide and its application. BACKGROUND

[0003] Patent WO2016184378 discloses a substituted pyrazole compound containing pyrimidine and its use, wherein the compounds represented by general formula I-A and I-B are reported to have good activity against various diseases.

[0004]

[0005] Respiratory inhibitor fungicides, nucleic acid metabolism inhibitor fungicides, cell wall synthesis inhibitor fungicides, signal transduction inhibitor fungicides, cell skeleton and motor protein inhibitor fungicides, sterol biosynthesis inhibitor fungicides, phospholipid synthesis inhibitor fungicides, cell wall synthesis inhibitor fungicides, methionine biosynthesis inhibitor fungicides are widely used and have outstanding control effect in agricultural production. Due to the single action site, the field efficacy of some varieties is significantly reduced after long-term repeated use. Multi-site inhibitor fungicides are a class of broad-spectrum protective fungicides, but this class of fungicides has poor therapeutic activity and requires a large field dosage.

[0006] In the practice of fungicide application, it is often found that a fungicide has good disease prevention effect at the initial stage, but as the number of uses increases, the dosage also gradually increases, and the efficacy improves little, sometimes even completely loses the disease prevention effect. The main reason is that the pathogen population has changed, that is, some pathogenic bacteria have acquired resistance plasmids through mutation and developed into dominant populations through natural selection, leading to the decrease of fungicide efficacy. At the same time, it is also recognized that after the application of pesticides, a part of them will be scattered on the soil or dispersed into the air, or flow into rivers and lakes with rainwater and farmland drainage, causing environmental pollution. Therefore, there is an urgent need for a pesticide product with high efficacy, small dosage, less environmental pollution, and the ability to delay the resistance of pathogenic bacteria.

[0007] Pesticide combination application is an important means to delay the development of drug resistance of pathogenic bacteria, and is also an effective method to reduce the amount of pesticides. The scientificity of fungicide combination application depends not only on the control object and the mechanism of action, but also on the nature of the combined effect after the mixed use of pesticides. Therefore, there are many restrictive factors for developing a high-efficiency fungicide composition with complementary action and significant synergistic effect, and the success rate is extremely low. SUMMARY

[0008] The present application aims to provide a synergistic fungicide composition containing a pyrimidine-containing substituted pyrazole compound and a fungicide and the use thereof.

[0009] To achieve the above-mentioned object, the technical scheme adopted by the present application is as follows:

[0010] A fungicide composition, the composition is two active components A and B, the weight ratio between the active component A and the active component B is 1:99-99:1.

[0011] Among them, the active component A is one or several of a pyrimidine-containing substituted pyrazole compound or its salt; the active component B is selected from a fungicide.

[0012] The active component A is a compound or its salt represented by general formula I-A or I-B:

[0013]

[0014] In the formula:

[0015] R1 is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C1-C4 alkylthio, halogenated C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C2-C4 alkenyl, halogenated C2-C4 alkenyl, C2-C4 alkynyl, halogenated C2-C4 alkynyl, C3-C4 alkenyloxy, halogenated C3-C4 alkenyloxy, C3-C4 alkynyloxy, halogenated C3-C4 alkynyloxy, C1-C4 alkylamino, di(C1-C4 alkyl)amino, C1-C4 alkylaminocarbonyl, halogenated C1-C4 alkylaminocarbonyl, C1-C4 alkoxycarbonyl, halogenated C1-C4 alkoxycarbonyl, C1-C4 alkoxyC1-C4 alkyl or C1-C4 alkylthioC1-C4 alkyl;

[0016] R2 is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy or halogenated C1-C4 alkoxy;

[0017] R3is selected from the group consisting of hydrogen, hydroxyl, formyl, C1-C4alkyl, haloC1-C4alkyl, C1-C4alkoxy, haloC1-C4alkoxy, C3-C4cycloalkyl, C1-C4alkylthio, C2-C4alkenylthio, C2-C4alkenyl, C2-C4alkinyl, haloC2-C4alkenyl, haloC2-C4alkinyl, C1-C4alkoxyC1-C4alkyl, haloC1-C4alkoxyC1-C4alkyl, C1-C4alkylthioC1-C4alkyl, haloC1-C4alkylthioC1-C4alkyl, C1-C4alkylsulfinyl, haloC1-C4alkylsulfinyl, C1-C4alkylsulfonyl, haloC1-C4alkylsulfonyl, C1-C4alkylaminosulfonyl, di(C1-C4alkyl)aminosulfonyl, C1-C4alkylsulfonylaminocarbonyl, C1-C4alkylcarbonylaminosulfonyl, C3-C4cycloalkyloxycarbonyl, C1-C4alkylcarbonyl, haloC1-C4alkylcarbonyl, C1-C4alkoxycarbonyl, haloC1-C4alkoxycarbonyl, C1-C4alkylcarbonylC1-C4alkyl, C1-C4alkoxycarbonylC1-C4alkyl, C1-C4alkylaminocarbonyl, di(C1-C4alkyl)aminocarbonyl, C2-C4alkenyloxycarbonyl, C2-C4alkynyloxycarbonyl, C1-C4alkoxyC1-C4alkoxycarbonyl, C1-C4alkylaminothio, di(C1-C4alkyl)aminothio, arylcarbonylC1-C4alkyl, arylcarbonyl, aryloxycarbonyl, arylC1-C4alkyloxycarbonyl, arylC1-C4alkyl, heteroarylcarbonylC1-C4alkyl, heteroarylcarbonyl, heteroaryloxycarbonyl, heteroarylC1-C4alkyloxycarbonyl, or heteroarylC1-C4alkyl;

[0018] R4, R5, which can be identical or different, are each selected from the group consisting of hydrogen, halogen, C1-C4alkyl, haloC1-C4alkyl, C1-C4alkoxy, or haloC1-C4alkoxy; wherein R4, R5, together with the C to which they are attached, can also form a C3-C4ring;

[0019] R6, R7, which can be identical or different, are each selected from the group consisting of hydrogen, halogen, C1-C4alkyl, haloC1-C4alkyl, C1-C4alkoxy, or haloC1-C4alkoxy; wherein R6, R7, together with the C to which they are attached, can also form a C3-C4ring;

[0020] R8, R9, which can be identical or different, are each selected from the group consisting of hydrogen, cyano, halogen, C1-C4alkyl, haloC1-C4alkyl, C1-C4alkoxycarbonyl, haloC1-C4alkoxycarbonyl, unsubstituted or mono- to penta-substituted aryl, arylmethyl, arylcarbonyl, arylmethylcarbonyl, aryloxycarbonyl, heteroaryl, heteroarylmethyl, heteroarylcarbonyl, heteroarylmethylcarbonyl, or heteroaryloxycarbonyl; 11 R8, R9, which can be identical or different, are each selected from the group consisting of hydrogen, cyano, halogen, C1-C4alkyl, haloC1-C4alkyl, C1-C4alkoxycarbonyl, haloC1-C4alkoxycarbonyl, unsubstituted or mono- to penta-substituted aryl, arylmethyl, arylcarbonyl, arylmethylcarbonyl, aryloxycarbonyl, heteroaryl, heteroarylmethyl, heteroarylcarbonyl, heteroarylmethylcarbonyl, or heteroaryloxycarbonyl;

[0021] R11 selected from halogen, hydroxy, amino, cyano, nitro, C1-C4alkyl, haloC1-C4alkyl, C1-C4alkoxy, haloC1-C4alkoxy, C3-C4cycloalkyl, C1-C4alkylamino, haloC1-C4alkylamino, di(C1-C4alkyl)amino, halo di(C1-C4alkyl)amino, C1-C4alkylthio, haloC1-C4alkylthio, C2-C4alkenyl, C2-C4alkynyl, C2-C4alkenyloxy, haloC2-C4alkenyloxy, C2-C4alkynyloxy, haloC2-C4alkynyloxy, C1-C4alkylsulfonyl, haloC1-C4alkylsulfonyl, C1-C4alkylcarbonyl, haloC1-C4alkylcarbonyl, C1-C4alkoxycarbonyl, haloC1-C4alkoxycarbonyl, C1-C4alkoxyC1-C4alkyl, haloC1-C4alkoxyC1-C4alkyl, C1-C4alkylthioC1-C4alkyl, haloC1-C4alkylthioC1-C4alkyl, C1-C4alkoxycarbonylC1-C4alkyl, haloC1-C4alkoxycarbonylC1-C4alkyl, C1-C4alkylthiocarbonylC1-C4alkyl, haloC1-C4alkylthiocarbonylC1-C4alkyl, C1-C4alkylcarbonyloxy, haloC1-C4alkylcarbonyloxy, C1-C4alkoxycarbonyloxy, haloC1-C4alkoxycarbonyloxy, C1-C4alkylsulfonyloxy, haloC1-C4alkylsulfonyloxy, C1-C4alkoxyC1-C4alkoxy or haloC1-C4alkoxyC1-C4alkoxy; n is an integer selected from 0 to 5, when n is greater than 1, the R 11 may be the same or different;

[0022] R 14 , R 15 , R 16 or R 17 may be the same or different, and are each selected from hydrogen, halogen, hydroxy, amino, cyano, nitro, C1-C4alkyl, haloC1-C4alkyl, C1-C4alkoxy, haloC1-C4alkoxy or C3-C4cycloalkyl;

[0023] W is selected from hydrogen, halogen, C1-C4alkyl, haloC1-C4alkyl, C3-C4cycloalkyl, C1-C4alkoxy, C1-C4alkylthio or C1-C4alkylsulfonyl;

[0024] The salt of the imidazole-containing substituted pyrazole compound is a salt of a compound of general formula I-A or I-B with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid, maleic acid, fumaric acid, sorbic acid, malic acid or citric acid;

[0025] The active component B is selected from one or more of respiratory inhibitor fungicides, nucleic acid metabolism inhibitor fungicides, cell wall synthesis inhibitor fungicides, signal transduction inhibitor fungicides, cytoskeleton and motor protein inhibitor fungicides, sterol biosynthesis inhibitor fungicides, phospholipid synthesis inhibitor fungicides, methionine biosynthesis inhibitor fungicides, multi-site inhibitor fungicides, and fungicides with unknown mechanisms of action.

[0026] When the active component A is a compound of formula IA or a salt thereof, preferably, the composition comprises the active component A and the active component B in a weight ratio of 1:50 to 50:1;

[0027] Wherein, the active component A is selected from one or more of the compounds of formula IA or their salts;

[0028] wherein: R3 is selected from hydrogen, hydroxy, formyl, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkoxy, C3-C4 cycloalkyl, C1-C4 alkylthio, C2-C4 alkenylthio, C2-C4 alkenyl, C2-C4 alkynyl, halo-C2-C4 alkenyl or halo-C2-C4 alkynyl;

[0029] R4 and R5 may be the same or different and are independently selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy or halo-C1-C4 alkoxy; R6 and R7 may be the same or different and are independently selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy or halo-C1-C4 alkoxy; R8 and R9 may be the same or different and are independently selected from hydrogen, cyano, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxycarbonyl or halo-C1-C4 alkoxycarbonyl; R 11 is selected from halogen, hydroxy, amino, cyano, nitro, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C3-C4 cycloalkyl, C1-C4 alkylamino, halogenated C1-C4 alkylamino, di(C1-C4 alkyl)amino, halogenated di(C1-C4 alkyl)amino or C1-C4 alkylthio; n is an integer selected from 0 to 5, when n is 0, there is no substituent on the phenyl ring; when n is greater than 1, R 11 Can be the same or different; R 14 、R 15 、R 16 or R 17 may be the same or different and are independently selected from hydrogen, halogen, hydroxy, amino, cyano, nitro, C1-C4 alkyl, halo-C1-C4 alkyl or C1-C4 alkoxy; W is selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 alkoxy or C1-C4 alkylthio;

[0030] The salt of the compound of Formula I-A is a salt of the compound of Formula I-A with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid, or maleic acid;

[0031] The active component B is selected from flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl B45, metalaxyl-M B46, iprovalicarb B47, cymoxanil B48, benalaxyl-M B49, flusulfamide B50, tiadinil B51, ethaboxam B52, cyflufenamid B53, fenhexamid B54, diclocymet B55, bupirimate B56, dimethirimol B57, ethirimol B58, hymexazol B59, octhilinone B60, ofurace B61, chinomethionat B62, metidaxyl B63, furalaxyl B64, fludioxonil B65, fenpicloni B66, iprodione B67, procymidone B68, meclozolin B69, chlozolinate B70, dimethachlon B71, vinclozolin B72, diethofencarb B73, metrafenone B74, pyriofenone B75, ferimzone B76, acibenzolar-S-methyl B77, probenazole B78, isotianil B79, tiadinil B80, proquinazid B81, zoletil B82, pyraclostrobin B83, carpropamid B84, guazatin-acetate B85, spiroxamine B86, triclopyr B87, tricyclazole B88, cyprodinil B89, anilazin B90, pyrimethanil B91, ferbam B92, benthival B93, captan B94, dithianon B95, tolylfluanid B96, topron B97, nitrothal-isopropyl B98, diclomezni B99, nitrothal B100, phthalide B101, chlorothalonil B102, dichlofluanid B103, flusulfamide B104, tolylfluanid B105, flutolanil B106, zoxamide B107, metrafenone B108, metominostrobin B109, tebufloquin B110, pyrifenox B111, pyrisoxazole B112, zoxamide B113, metrafenone B114, metominostrobin B115, tebufloquin B116, pyrifenox B117, pyrisoxazole B118, zoxamide B119, metrafenone B120, metominostrobin B121, tebufloquin B122, pyrifenox B123, pyrisoxazole B124, zoxamide B125, metrafenone B126, metominostrobin B127, tebufloquin B128, pyrifenox B129, pyrisoxazole B130, zoxamide B131, metrafenone B132, metominostrobin B133, tebufloquin B134, pyrifenox B135, pyrisoxazole B136, zoxamide B137, metrafenone B138, metominostrobin B139, tebufloquin B140, pyrifenox B141, pyrisoxazole B142, zoxamide B143, metrafenone B144, metominostrobin B145, tebufloquin B146, pyrifenox B147, pyrisoxazole B148, zoxamide B149, metrafenone B150, metominostrobin B151, tebufloquin B152, pyrifenox B153, pyrisoxazole B154, zoxamide B155, metrafenone B156, metominostrobin B157, tebufloquin B158, pyrifenox B159, pyrisoxazole B160, zoxamide B161, metrafenone B162, metominostrobin B163, tebufloquin B164, pyrifenox B165, pyrisoxazole B166, zoxamide B167, metrafenone B168, metominostrobin B169, tebufloquin B170, pyrifenox B171, pyrisoxazole B172, zoxamide B173, metrafenone B174, metominostrobin B175, tebufloquin B176, pyrifenox B177, pyrisoxazole BB75 carbendazim B76 thiophanate-methyl B77 phenamacril B78 benomyl B79 fuberidazole B80 thiabendazole B81 thiophanate B82 pencycuron B83 etaconazole B84 ethanone B85 fenarimol B86 fenbuconazole B87 fenpropidine B88 fenpropimorph B89 fenpyrazamine B90 mefentrifluconazole B91 nuarimol B92 oxpoconazole B93 perfurazoate B94 prochloraz B95 spiroxamine B96 pyrisoxazole B97 tridemorph B98 triforine B99 dodemorph B100 bromuconazole B101 triapenthenol B102 naftifine B103 simeconazole B104 triflumizole B105 ipfentrifluconazole B106 tecnazene B107 chloroneb B108 dicloran B109 biphenyl B110 edifenphos B111 etridiazole B112 iodocarb B113 iprobenfos B114 isoprothiolane B115 oxathiapiprolin B116 fluoxapiprolineB117 propamocarb B118 prothiocarb B119 pyrazophos B120 quintozene B121 tolclofos-methyl B122 benthiavalicarb-isopropyl B123 polyoxin B124 valifenalate B125 pyrimorph B126 blasticidin-s B127 cyprodinil B128 kasugamycin B129 mepanipyrim B130 pyrimethanil B131 streptomycin B132 oxytetracycline B133 zineb B134 mancozeb B135 metiram B136 propineb B137 maneb B138 amobam B139 nabam B140 etem B141 milneb B142 mancopper B143 cufraneb B144 sulphur B145 anilazine B146 captan B147 chinomethionat B148 chlorothalonil B149 dichlofluanid B150 tolylfluanid B151 dithianon B152 fluoroimide B153 methasulfocarb B154 captafol B155 folpet B156 iminoctadine B157 guazatine B158 zinc thiazole B159 oxine-copper B160 thiodiazole-copper B161 cuppric nonyl phenolsulfonate B162 picarbutrazox B163 aminopyrifenB164, metyltetraprole B165, dodine B166, pyridachlometyl B167, diclomezine B168, validamycin B169, ferimzone B170, tebufloquin B171, triazoxide B172, quinofumelin B173, ipflufenoquin B174, dipymetitrone B175, teclofthalam B176, or several of these.

[0032] It is further preferred that the composition comprises active ingredient A and active ingredient B in a weight ratio of 1 :20 to 20:1 ;

[0033] wherein active ingredient A is one or several of the compounds of the general formula I-A or salts thereof;

[0034] wherein R3is selected from the group consisting of hydrogen, hydroxyl, formyl, C1-C4alkyl, halogenated C1-C4alkyl, C1-C4alkoxy, halogenated C1-C4alkoxy, C3-C4cycloalkyl, C1-C4alkylthio, C2-C4alkenylthio, C2-C4alkenyl, C2-C4alkynyl, halogenated C2-C4alkenyl or halogenated C2-C4alkynyl; R4, R5may be the same or different and are independently selected from the group consisting of hydrogen, halogen, C1-C4alkyl, halogenated C1-C4alkyl, C1-C4alkoxy or halogenated C1-C4alkoxy; R6, R7may be the same or different and are independently selected from the group consisting of hydrogen, halogen, C1-C4alkyl, halogenated C1-C4alkyl, C1-C4alkoxy or halogenated C1-C4alkoxy; R8, R9may be the same or different and are independently selected from the group consisting of hydrogen, cyano, halogen, C1-C4alkyl, halogenated C1-C4alkyl, C1-C4alkoxycarbonyl or halogenated C1-C4alkoxycarbonyl; R 11 selected from the group consisting of halogen, hydroxyl, amino, cyano, nitro, C1-C4alkyl, halogenated C1-C4alkyl, C1-C4alkoxy, halogenated C1-C4alkoxy, C3-C4cycloalkyl, C1-C4alkylamino or halogenated C1-C4alkylamino; n is an integer selected from 0 to 5, wherein when n is 0, the phenyl ring is unsubstituted; when n is greater than 1, the R 11 may be the same or different; R 14 , R 15 , R 16 or R 17which can be the same or different, are each selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro, C1-C4alkyl, haloC1-C4alkyl, C1-C4alkoxy or haloC1-C4alkoxy; W is selected from hydrogen, halogen, C1-C4alkyl, haloC1-C4alkyl, C3-C4cycloalkyl, C1-C4alkoxy or C1-C4alkylthio;

[0035] The salts of the compounds of the general formula I-A are salts of the general compounds with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid or methanesulfonic acid;

[0036] The active component B is selected from flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl-M B46, iprovalicarb B47, cymoxanil B48, benalaxyl-M B49, tiadinil B51, ethaboxam B52, bupirimate B56, dimethirimol B57, ethirimol B58, hymexazol B59, octhilinone B60, ofurace B61, chinomethionat B62, fludioxonil B65, fenpicloni B66, iprodione B67, procymidone B68, dimethachlon B71, vinclozolin B72, diethofencarb B73, metrafenone B74, pyriofenone B75, carbendazim B76, thiophanate-methyl B77, phenamacril B78, benomyl B79, ethanone B85, fenarimol B86, fenbuconazole B87, fenpropidine B88, fenpyrazamine B90, mefentrifluconazole B91, nuarimol B92, oxpoconazole B93, perfurazoate B94, prochloraz B95, spiroxamine B96, pyrisoxazole B97, simeconazole B104, ipfentrifluconazoleB106, edifenphos B111, iprobenfos B114, isoprothiolane B115, oxathiapiprolin B116, fluoxapiproline B117, propamocarb B118, prothiocarb B119, pyrazophos B120, quintozene B121, tolclofos-methyl B122, benthiavalicarb-isopropyl B123, polyoxin B124, valifenalate B125, pyrimorph B126, cyprodinil B128, kasugamycin B129, mepanipyrim B130, pyrimethanil B131, streptomycin B132, zineb B134, mancozeb B135, metiram B136, propineb B137, maneb B138, amobam B139, milneb B142, mancopper B143, sulphur B145, anilazine B146, captan B147, chlorothalonil B149, dichlofluanid B150, tolylfluanid B151, methasulfocarb B154, captafol B155, folpet B156, zinc thiazole B159, oxine-copper B160, thiodiazole-copper B161, cuppric nonylphenolsulfonate B162, picarbutrazox B163, aminopyrifen B164, metyltetraprole B165, pyridachlometyl B167, validamycin B169, ferimzone B170, tebufloquinB171, quinofumelin B173, ipflufenoquin B174, dipymetitrone B175, teclofthalam B176, or several of these.

[0037] It is further preferred that the composition is active component A and active component B in a ratio of 1 : 10 to 10: 1 by weight;

[0038] wherein active component A is selected from one or several of the compounds of the general formula I-A or salts thereof;

[0039] wherein R3is selected from hydrogen, hydroxyl, formyl or C1-C4alkyl; R4, R5may be the same or different and are selected from hydrogen, halogen or C1-C4alkyl; R6, R7may be the same or different and are selected from hydrogen, halogen or C1-C4alkyl; R8, R9may be the same or different and are selected from hydrogen, cyano, halogen or C1-C4alkyl; R 11 selected from halogen, hydroxyl, amino, cyano, nitro or C1-C4alkyl; n is selected from an integer from 0 to 5, when n is 0, the phenyl ring is unsubstituted; when n is greater than 1, R 11 may be the same or different; R 14 , R 15 , R 16 or R 17 may be the same or different and are selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro or C1-C4alkyl; W is selected from hydrogen, halogen or C1-C4alkyl;

[0040] The salts of the compounds of the general formula I-A are salts of the general compounds with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;

[0041] active component B is selected from flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl-M B46, iprovalicarb B47, cymoxanil B48, tiadinil B51, ethaboxam B52, bupirimate B56, ethirimol B58, hymexazol B59, octhilinone B60, chinomethionat B62, fludioxonil B65, iprodione B67, procymidone B68, diethofencarb B73, metrafenone B74, pyriofenone B75, carbendazim B76, thiophanate-methyl B77, phenamacril B78, fenbuconazole B87, mefentrifluconazole B91, nuarimol B92, prochloraz B95, spiroxamine B96, pyrisoxazole B97, simeconazole B104, ipfentrifluconazoleB106, iprobenfos B114, isoprothiolane B115, oxathiapiprolin B116, fluoxapiproline B117, propamocarb B118, quintozene B121, tolclofos-methyl B122, benthiavalicarb-isopropyl B123, polyoxin B124, valifenalate B125, pyrimorph B126, cyprodinil B128, kasugamycin B129, pyrimethanil B131, streptomycin B132, zineb B134, mancozeb B135, metiram B136, propineb B137, sulphur B145, captan B147, chlorothalonil B149, dichlofluanid B150, captafol B155, folpet B156, zine thiazole B159, oxine-copper B160, thiodiazole-copper B161, cuppric nonyl phenolsulfonate B162, picarbutrazox B163, aminopyrifen B164, metyltetraprole B165, pyridachlometyl B167, validamycin B169, tebufloquin B171, quinofumelin B173, ipflufenoquin B174, dipymetitrone B175, teclofthalam B176.

[0042] When the active component A is a compound according to general formula I-B or a salt thereof, preferably the composition is active component A and active component B in a ratio of 1 :50 to 50:1 by weight;

[0043] wherein the active component A is selected from one or more of the compounds according to general formula I-B or a salt thereof;

[0044] wherein R1is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4alkyl, haloC1-C4alkyl, C3-C4cycloalkyl, C1-C4alkoxy, haloC1-C4alkoxy, C1-C4alkylthio, haloC1-C4alkylthio, C1-C4alkylsulfinyl, C1-C4alkylsulfonyl, C2-C4alkenyl, haloC2-C4alkenyl, C2-C4alkynyl or haloC2-C4alkynyl; R2is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C1-C4alkyl or haloC1-C4alkyl; R3is selected from hydrogen, hydroxyl, formyl, C1-C4alkyl, haloC1-C4alkyl, C1-C4alkoxy, haloC1-C4alkoxy, C3-C4cycloalkyl, C1-C4alkylthio, C2-C4alkenylthio, C2-C4alkenyl, C2-C4alkynyl, haloC2-C4alkenyl or haloC2-C4alkynyl; R4, R5, which can be the same or different, are independently selected from hydrogen, halogen, C1-C4alkyl, haloC1-C4alkyl, C1-C4alkoxy or haloC1-C4alkoxy; R6, R7, which can be the same or different, are independently selected from hydrogen, halogen, C1-C4alkyl, haloC1-C4alkyl, C1-C4alkoxy or haloC1-C4alkoxy; R8, R9, which can be the same or different, are independently selected from hydrogen, cyano, halogen, C1-C4alkyl, haloC1-C4alkyl, C1-C4alkoxycarbonyl or haloC1-C4alkoxycarbonyl; R 11 selected from halogen, hydroxyl, amino, cyano, nitro, C1-C4alkyl, haloC1-C4alkyl, C1-C4alkoxy, haloC1-C4alkoxy, C3-C4cycloalkyl, C1-C4alkylamino, haloC1-C4alkylamino, di(C1-C4alkyl)amino, halo-di(C1-C4alkyl)amino or C1-C4alkylthio; n is selected from an integer from 0 to 5, when n is 0, the phenyl ring is unsubstituted; when n is greater than 1, R 11 which can be the same or different; W is selected from hydrogen, halogen, C1-C4alkyl, haloC1-C4alkyl, C3-C4cycloalkyl, C1-C4alkoxy or C1-C4alkylthio;

[0045] The salt of the compound of the general formula l-B is a salt of the compound of the general formula with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid;

[0046] Active ingredient B is selected from dinocap B40, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl B45, metalaxyl-M B46, iprovalicarb B47, cymoxanil ) B48, benalaxyl-M B49, flusulfamide B50, tiadinil B51, ethaboxam B52, cyflufenamid B53, fenhexamid B54, diclocymet B55, bupirimate B56, dimethicone thirimol B57, ethirimol B58, hymexazol B59, octhilinone B60, ofurace B61, chinomethionat B62, metidaxyl B63, furaxyl B64, fludioxonil B65, fenpicloni B66, iprodione B67, procymidone B68, meclozolin B69, chlozolinate B70, dimethachlon B71, vinclozolin B72, diethofencarb B73, metrafenone B74, pyriofenoneB75 carbendazim B76 thiophanate-methyl B77 phenamacril B78 benomyl B79 fuberidazole B80 thiabendazole B81 thiophanate B82 pencycuron B83 etaconazole B84 ethanone B85 fenarimol B86 fenbuconazole B87 fenpropidine B88 fenpropimorph B89 fenpyrazamine B90 mefentrifluconazole B91 nuarimol B92 oxpoconazole B93 perfurazoate B94 prochloraz B95 spiroxamine B96 pyrisoxazole B97 tridemorph B98 triforine B99 dodemorph B100 bromuconazole B101 triapenthenol B102 naftifine B103 simeconazole B104 triflumizole B105 ipfentrifluconazole B106 tecnazene B107 chloroneb B108 dicloran B109 biphenyl B110 edifenphos B111 etridiazole B112 iodocarb B113 iprobenfos B114 isoprothiolane B115 oxathiapiprolin B116 fluoxapiprolineB117 propamocarb B118 prothiocarb B119 pyrazophos B120 quintozene B121 tolclofos-methyl B122 benthiavalicarb-isopropyl B123 polyoxin B124 valifenalate B125 pyrimorph B126 blasticidin-s B127 cyprodinil B128 kasugamycin B129 mepanipyrim B130 pyrimethanil B131 streptomycin B132 oxytetracycline B133 zineb B134 mancozeb B135 metiram B136 propineb B137 maneb B138 amobam B139 nabam B140 etem B141 milneb B142 mancopper B143 cufraneb B144 sulphur B145 anilazine B146 captan B147 chinomethionat B148 chlorothalonil B149 dichlofluanid B150 tolylfluanid B151 dithianon B152 fluoroimide B153 methasulfocarb B154 captafol B155 folpet B156 iminoctadine B157 guazatine B158 zinc thiazole B159 oxine-copper B160 thiodiazole-copper B161 cuppric nonyl phenolsulfonate B162 picarbutrazox B163 aminopyrifenB164, metyltetraprole B165, dodine B166, pyridachlometyl B167, diclomezine B168, validamycin B169, ferimzone B170, tebufloquin B171, triazoxide B172, quinofumelin B173, ipflufenoquin B174, dipymetitrone B175, teclofthalam B176.

[0047] Further preferred, the composition is active component A and active component B in a ratio of 1 :20 to 20:1 by weight;

[0048] wherein active component A is selected from one or more of the compounds of the general formula I-B or salts thereof;

[0049] wherein R1is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4alkyl or halogenated C1-C4alkyl; R2is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C1-C4alkyl or halogenated C1-C4alkyl; R3is selected from hydrogen, hydroxyl, formyl, C1-C4alkyl, halogenated C1-C4alkyl, C1-C4alkoxy, halogenated C1-C4alkoxy, C3-C4cycloalkyl, C1-C4alkylthio, C2-C4alkenylthio, C2-C4alkenyl, C2-C4alkynyl, halogenated C2-C4alkenyl or halogenated C2-C4alkynyl; R4, R5may be the same or different and are each selected from hydrogen, halogen, C1-C4alkyl, halogenated C1-C4alkyl, C1-C4alkoxy or halogenated C1-C4alkoxy; R6, R7may be the same or different and are each selected from hydrogen, halogen, C1-C4alkyl, halogenated C1-C4alkyl, C1-C4alkoxy or halogenated C1-C4alkoxy; R8, R9may be the same or different and are each selected from hydrogen, cyano, halogen, C1-C4alkyl, halogenated C1-C4alkyl, C1-C4alkoxycarbonyl or halogenated C1-C4alkoxycarbonyl; R 11 selected from halogen, hydroxyl, amino, cyano, nitro, C1-C4alkyl, halogenated C1-C4alkyl, C1-C4alkoxy, halogenated C1-C4alkoxy, C3-C4cycloalkyl, C1-C4alkylamino or halogenated C1-C4alkylamino; n is selected from an integer from 0 to 5, when n is 0, the phenyl ring is unsubstituted; when n is greater than 1, R 11 may be the same or different; W is selected from hydrogen, halogen, C1-C4alkyl, halogenated C1-C4alkyl, C3-C4cycloalkyl, C1-C4alkoxy or C1-C4alkylthio;

[0050] The salt of the compound represented by the general formula I-B is a salt of the general compound with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, or methanesulfonic acid;

[0051] The active component B is selected from the group consisting of benzovindiflupyr B1, penflufen B2, isopyrazam B3, fluxapyroxad B4, fluopyram B5, flubeneteram B6, sedaxane B7, penthiopyrad B8, boscalid B9, bixafen B10, flutolanil B11, furametpyr B12, thifluzamide B13, pydiflumetofen B14, fluindapyr B15, fluopimomide B16, isofetamid B17, inpyrfluxam B18, isoflucypram B19, pyraziflumid B20, pyrapropoyne B21, benodanil B26, fluopicolide B27, fenamidone B28, famoxadone B29, cyazofamid B30, ametoctradin B31, fluazinam B32, fenpicoxamid B33, florylpicoxamid B34, pyridinitrile B35, pyridinyl-oxime B36, pyridinyl-oxime B37, pyridinyl-oxime B38, pyridinyl-oxime B39, pyridinyl-oxime B40, pyridinyl-oxime B41, pyridinyl-oxime B42, pyridinyl-oxime B43, pyridinyl-oxime B44, pyridinyl-oxime B45, pyridinyl-oxime B46, pyridinyl-oxime B47, pyridinyl-oxime B48, pyridinyl-oxime B49, pyridinyl-oxime B50, pyridinyl-oxime B51, pyridinyl-oxime B52, pyridinyl-oxime B53, pyridinyl-oxime B54, pyridinyl-oxime B55, pyridinyl-oxime B56, pyridinyl-oxime B57, pyridinyl-oxime B58, pyridinyl-oxime B59, pyridinyl-oxime B60, pyridinyl-oxime B61, pyridinyl-oxime B62, pyridinyl-oxime B63, pyridinyl-oxime B64, pyridinyl-oxime B65, pyridinyl-oxime B66, pyridinyl-oxime B67, pyridinyl-oxime B68, pyridinyl-oxime B69, pyridinyl-oxime B70, pyridinyl-oxime B71, pyridinyl-oxime B72, pyridinyl-oxime B73, pyridinyl-oxime B74, pyridinyl-oxime B75, pyridinyl-oxime B76, pyridinyl-oxime B77, pyridinyl-oxime B78, pyridinyl-oxime B79, pyridinyl-oxime B80, pyridinyl-oxime B81, pyridinyl-oxime B82, pyridinyl-oxime B83, pyridinyl-oxime B84, pyridinyl-oxime B85, pyridinyl-oxime B86, pyridinyl-oxime B87, pyridinyl-oxime B88, pyridinyl-oxime B89, pyridinyl-oxime B90, pyridinyl-oxime B91, pyridinyl-oxime B92, pyridinyl-oxime B93, pyridinyl-oxime B94, pyridinyl-oxime B95, pyridinyl-oxime B96, pyridinyl-oxime B97, pyridinyl-oxime B98, pyridinyl-oxime B99, pyridinyl-oxime B100, pyridinyl-oxime B101, pyridinyl-oxime B102, pyridinyl-oxB34, amisulbrom B35, silthiopham B36, pyribencarb B37, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl-M B46, iprovalicarb B47, cymoxanil B48, benalaxyl-M B49, tiadinil B51, ethaboxam B52, bupirimate B56, dimethirimol B57, ethirimol B58, hymexazol B59, octhilinone B60, ofurace B61, chinomethionat B62, fludioxonil B65, fenpicloni B66, iprodione B67, procymidone B68, dimethachlon B71, vinclozolin B72, diethofencarb B73, metrafenone B74, pyriofenone B75, carbendazim B76, thiophanate-methyl B77, phenamacril B78, benomyl B79, ethanone B85, fenarimol B86, fenbuconazole B87, fenpropidine B88, fenpyrazamine B90, mefentrifluconazole B91, nuarimol B92, oxpoconazole B93, perfurazoate B94, prochloraz B95, spiroxamine B96, pyrisoxazole B97, simeconazole B104, ipfentrifluconazoleB106, edifenphos B111, iprobenfos B114, isoprothiolane B115, oxathiapiprolin B116, fluoxapiproline B117, propamocarb B118, prothiocarb B119, pyrazophos B120, quintozene B121, tolclofos-methyl B122, benthiavalicarb-isopropyl B123, polyoxin B124, valifenalate B125, pyrimorph B126, cyprodinil B128, kasugamycin B129, mepanipyrim B130, pyrimethanil B131, streptomycin B132, zineb B134, mancozeb B135, metiram B136, propineb B137, maneb B138, amobam B139, milneb B142, mancopper B143, sulphur B145, anilazine B146, captan B147, chlorothalonil B149, dichlofluanid B150, tolylfluanid B151, methasulfocarb B154, captafol B155, folpet B156, zinc thiazole B159, oxine-copper B160, thiodiazole-copper B161, cuppric nonyl phenolsulfonate B162, picarbutrazox B163, aminopyrifen B164, metyltetraprole B165, pyridachlometyl B167, validamycin B169, ferimzone B170, tebufloquinB171, quinofumelin B173, ipflufenoquin B174, dipymetitrone B175, teclofthalam B176, or several of these.

[0052] It is further preferred that the composition is active component A and active component B in a ratio of 1 : 10 to 10: 1 by weight;

[0053] wherein active component A is selected from one or several of the compounds of the general formula l-B or salts thereof;

[0054] wherein R1is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl or C1-C4alkyl; R2is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl or C1-C4alkyl; R3is selected from hydrogen, hydroxyl, formyl or C1-C4alkyl; R4, R5may be the same or different and are selected from hydrogen, halogen or C1-C4alkyl; R6, R7may be the same or different and are selected from hydrogen, halogen or C1-C4alkyl; R8, R9may be the same or different and are selected from hydrogen, cyano, halogen or C1-C4alkyl; R10is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl or C1-C4alkyl; and n is an integer from 0 to 5, wherein when n is 0, the phenyl ring is unsubstituted; and when n is greater than 1, R 11 selected from halogen, hydroxyl, amino, cyano, nitro or C1-C4alkyl; n is an integer from 0 to 5, wherein when n is 0, the phenyl ring is unsubstituted; and when n is greater than 1, R 11 may be the same or different; and W is selected from hydrogen, halogen or C1-C4alkyl;

[0055] The salts of the compounds of the general formula l-B are salts of the general compounds with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;

[0056] The active ingredient B is selected from benzovindiflupyr B1, penflufen B2, isopyrazam B3, fluxapyroxad B4, fluopyram B5, flubeneteram B6, sedaxane B7, penthiopyrad B8, boscalid B9, bixafen B10, thifluzamide B13, pydiflumetofen B14, fluindapyr B15, fluopimomide B16, inpyrfluxam B18, isoflurane B19, pyraziflumid B20, pyrapropoyne B21, benodanil B26, fluopicolide B27, fenamidone B28, famoxadone B29, cyazofamid B30, ametoctradin B31, fluazinam B32, fenpicoxamid B33, florylpicoxamid B34, silthiopham B36, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl-M B46, iprovalicarb B47, cymoxanil B48, tiadinil B51, ethaboxam B52, pyrimidine sulfonate Bupirimate B56, ethirimol B58, hymexazol B59, octhilinone B60, chinomethionat B62, fludioxonil B65, iprodione B67, procymidone B68, diethofencarb B73, metrafenone B74, pyriofenoneB75, carbendazim B76, thiophanate-methyl B77, phenamacril B78, fenbuconazole B87, mefentrifluconazole B91, nuarimol B92, prochloraz B95, spiroxamine B96, pyrisoxazole B97, simeconazole B104, ipfentrifluconazole B106, iprobenfos B114, isoprothiolane B115, oxathiapiprolin B116, fluoxapiproline B117, propamocarb B118, quintozene B121, tolclofos-methyl B122, benthiavalicarb-isopropyl B123, polyoxin B124, valifenalate B125, pyrimorph B126, cyprodinil B128, kasugamycin B129, pyrimethanil B131, streptomycin B132, zineb B134, mancozeb B135, metiram B136, propineb B137, sulphur B145, captan B147, chlorothalonil B149, dichlofluanid B150, captafol B155, folpet B156, zine thiazole B159, oxine-copper B160, thiodiazole-copper B161, cuppric nonyl phenolsulfonate B162, picarbutrazox B163, aminopyrifen B164, metyltetraprole B165, pyridachlometylB167, validamycin B169, tebufloquin B171, quinofumelin B173, ipflufenoquin B174, dipymetitrone B175, teclofthalam B176, or one or more of them.

[0057] Use of a fungicidal composition for the preparation of a medicament for controlling plant pathogenic fungi, bacterial diseases

[0058] The plant pathogenic fungi, bacterial diseases are plant powdery mildew, rust, black spot, leaf mildew, thread blight, stand blight, black nodule disease, black smut, smut, downy mildew, late blight, blight, downy blight, black leg, downy disease, wilt disease, downy disease, white rust, black spot, leaf spot, early blight, anthracnose, brown spot, wilt disease, gray mold, sclerotinia, rot disease, root rot, sclerotinia, soft rot, white leaf wilt, leaf wilt, angular spot, round spot, white leaf wilt, bacterial wilt, or yellow dragon disease.

[0059] A fungicidal preparation, the effective component of the preparation is the fungicidal composition, and the weight percentage of the fungicidal composition is 0.1-95%.

[0060] According to the occurrence degree of crop diseases, the use concentration of the composition of the present application in the crop planting area is 5-500 mg / L (effective component content, the same below), preferably 50-200 mg / L.

[0061] The active component A and at least one active component B in the composition of the present application are prepared according to the suitable ratio provided by the present application, or prepared on site or used separately.

[0062] The composition of the present application is suitable for the prevention and treatment of fungal and bacterial diseases of trees (apple, rubber, pear, citrus, hawthorn, chestnut, prickly ash, medlar, mango, papaya, lychee, banana, peach tree, etc.), vines (grapes, etc.), melons and vegetables (tomato, eggplant, pepper, cucumber, melon, winter melon, watermelon, pumpkin, bitter gourd, loofah, chayote, gourd, zucchini, lettuce, potato, carrot), legumes (peas, beans, cowpea), cereals (wheat, rice, corn, sorghum, etc.), oil crops (rape, soybean, peanut, sesame, etc.), alliums (onion, garlic, onion), economic crops (tobacco, etc.), flowers and turf, as well as seed treatment, fruit preservation and other applications.

[0063] The fungicidal composition of the present application is particularly suitable for preventing and treating the following plant diseases: apple tree powdery mildew, rubber tree powdery mildew, citrus powdery mildew, hawthorn powdery mildew, chestnut powdery mildew, prickly ash powdery mildew, wolfberry powdery mildew, mango powdery mildew, papaya powdery mildew, rod powdery mildew, grape powdery mildew, tomato powdery mildew, eggplant powdery mildew, pepper powdery mildew, cucumber powdery mildew, melon powdery mildew, winter melon powdery mildew, watermelon powdery mildew, pumpkin powdery mildew, bitter gourd powdery mildew, loofah powdery mildew, calabash powdery mildew, zucchini powdery mildew, lettuce powdery mildew, pea powdery mildew, bean powdery mildew, wheat powdery mildew, barley powdery mildew, rose powdery mildew, rose powdery mildew, chrysanthemum powdery mildew, turf grass powdery mildew, carrot powdery mildew, apple tree rust, pear tree rust, soybean rust, pea rust, bean rust, cowpea rust, wheat rust, barley rust, corn rust, onion rust, garlic rust, onion rust, turf grass rust, apple tree anthracnose, rubber tree anthracnose, pear tree anthracnose, citrus anthracnose, hawthorn anthracnose, chestnut anthracnose, prickly ash anthracnose, wolfberry anthracnose, mango anthracnose, papaya anthracnose, hazel anthracnose, grape anthracnose, tomato anthracnose, eggplant anthracnose, pepper anthracnose, melon anthracnose, winter melon anthracnose, watermelon anthracnose, pumpkin anthracnose, bitter gourd anthracnose, loofah anthracnose, calabash anthracnose, zucchini anthracnose, lettuce anthracnose, cucumber downy mildew, grape downy mildew, melon downy mildew, bitter gourd downy mildew, loofah downy mildew, tomato late blight, potato late blight, pepper late blight, cucumber sudden collapse disease, eggplant sudden collapse disease, pepper sudden collapse disease, pear tree brown spot disease, cucumber brown spot disease, pear tree black spot disease, rose black spot disease, chrysanthemum black spot disease, soybean brown spot disease, cowpea red spot disease, apple spot and defoliation disease, bean wheel spot disease, eggplant rod spot disease, potato black scab disease, wheat leaf spot disease, rice leaf spot disease, rice bacterial leaf spot disease, tomato bacterial wilt disease, cucumber bacterial angular spot disease, and crop gray mold caused by Botrytis and Sclerotinia pathogenic bacteria, and sclerotinia disease.

[0064] The present application has the following advantages:

[0065] The present application combines active component A and fungicide active component B in different proportions, and the "observed efficacy" is greater than the "calculated efficacy", and the synergistic effect is very obvious, which can reduce the dosage of the pesticide and reduce environmental pollution. The present application mixes fungicides with different mechanisms of action, which helps to delay the development of drug resistance of pathogenic bacteria, provides an effective solution to the problem of fungicide resistance faced by agricultural production and the pesticide industry, and prolongs the service life of the pesticide. DETAILED DESCRIPTION

[0066] The synergistic effect of the composition of the present application on harmful fungi and bacterial diseases can be further illustrated by the following examples, but the present application is by no means limited to this. The active components described herein are the compounds A and bactericides B in the bactericidal composition of the present application;

[0067] The preparation of compound A is described in WO2016184378, and the bactericide B is selected from one or more of the following: respiratory inhibitor bactericides, nucleic acid metabolism inhibitor bactericides, cell wall synthesis inhibitor bactericides, signal transduction inhibitor bactericides, cell skeleton and motor protein inhibitor bactericides, sterol biosynthesis inhibitor bactericides, phospholipid synthesis inhibitor bactericides, cell wall synthesis inhibitor bactericides, methionine biosynthesis inhibitor bactericides, multi-site inhibitor bactericides, and bactericides with unknown mechanism of action.

[0068] The test method and evaluation method are as follows:

[0069] The active samples to be tested are active component A, active component B, and the combination of active component A and active component B.

[0070] The active component A is one or more of active component A1, active component A2, active component A3, and active component A4;

[0071] The active component A1 is a compound A1 represented by general formula l-A;

[0072] The active component A2 is a salt formed by compound A1 and sulfuric acid;

[0073] The compound A1 is

[0074]

[0075] In the formula, R3 is selected from hydrogen, R4 and R5 are each selected from hydrogen, R6 and R7 are each selected from hydrogen, R8 and R9 are each selected from hydrogen, R 11 selected from 4-chloro, n = 1, R 14 , R 15 , R 16 or R 17 are each selected from hydrogen, and W is selected from hydrogen, i.e. compound A1;

[0076] The active component A3 is a compound A3 represented by general formula l-B;

[0077] The active component A4 is a salt formed by compound A3 and sulfuric acid:

[0078] The compound A3 is

[0079]

[0080] In the formula:

[0081] R3is selected from hydrogen, R4, R5are each selected from hydrogen, R6, R7are each selected from hydrogen, R8, R9are each selected from hydrogen, R 11 selected from 4-chloro, n = 1, R 14 , R 15 , R 16 or R 17 are each selected from hydrogen, W is selected from hydrogen, i.e. compound A3.

[0082] active ingredient B is benzovindiflucarb B1, fluazinam B4, fluopyram B5, boscalid B9, thifluzamide B13, fluaz- amide B14, fluopicolide B27, zoxamide B31, fluazinam B32, fenpicoxamid B33, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamid B44, mefenoxam B46, ethaboxam B56, ethirim S8, fludioxonil B65, di- chlorflurenol B73, metrafenone B74, acypetacs B78, chlo- rofluazuron B91, cyazofamid B95, flutianil B116, fluoxa- propyline B117, polyoxins B124, kasugamycin B129, zineb B134, mancozeb B135, metiram B136, propineb B137, captan B147, chlorothalonil B149, zineb B159, oxine-copper B160, picarbutrazox B163, aminopyrifen B164, metyl- tetraprole B165.

[0083] The test composition is active ingredient A1, each active ingredient B, active ingredient A1 and each active ingredient B respectively; wherein active ingredient B is a composition consisting of benzene enfluazolin B1, fluazinam B4, pyriflocam B5, boscalid B9, thifluzamide B13, fluazinam B14, fluopicolide B27, metiram B31, fluazinam B32, fenpicoxamid B33, flumorph B41, dimoxystrobin B42, dualiy B43, zoxamid B44, mefenoxam B46, ethirim S6, ethirim B58, fludioxonil B65, diethofencarb B73, metrafenone B74, aurobin B78, chlorothalonil B91, prochloraz B95, fluazinam B116, fluoxapiproline B117, polyoxin B124, kasugamycin B129, zineb B134, mancozeb B135, metiram B136, propineb B137, captan B147, chlorothalonil B149, zineb B159, oxine-copper B160, picarbutrazox B163, aminopyrifen B164, metyltetraprole B165.

[0084] The test composition is active ingredient A2 and / or with benzene enfluazolin B1, fluazinam B4, pyriflocam B5, boscalid B9, thifluzamide B13, fluazinam B14, fluopicolide B27, metiram B31, fluazinam B32, fenpicoxamid B33, flumorph B41, dimoxystrobin B42, dualiy B43, zoxamid B44, mefenoxam B46, ethirim S6, ethirim B58, fludioxonil B65, diethofencarb B73, metrafenone B74, aurobin B78, chlorothalonil B91, prochloraz B95, fluazinam B116, fluoxapiproline B117, polyoxin B124, kasugamycin B129, zineb B134, mancozeb B135, metiram B136, propineb B137, captan B147, chlorothalonil B149, zineb B159, oxine-copper B160, picarbutrazox B163, aminopyrifen B164, metyltetraprole B165 composition.

[0085] The test composition is a composition consisting of active ingredient A3, respectively, and / or with benzene enestroburin B1, fluazinam B4, pyrifluquinazon B5, boscalid B9, thifluzamide B13, fluazula B14, fluopicolide B27, zoxamide B31, fluazinam B32, fenpicoxamid B33, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, mefenoxam B46, ethaboxam B56, ethaboxam B58, fludioxonil B65, diethofencarb B73, metrafenone B74, aurobin B78, chlorothalonil B91, prothioconazole B95, fluazinam B116, fluoxapiproline B117, polyoxin B124, kasugamycin B129, zineb B134, mancozeb B135, metiram B136, propineb B137, captan B147, chlorothalonil B149, zineb B159, oxine-copper B160, picarbutrazox B163, aminopyrifen B164, metyltetraprole B165.

[0086] The test composition is a composition consisting of active ingredient A4, respectively, and / or with benzene enestroburin B1, fluazinam B4, pyrifluquinazon B5, boscalid B9, thifluzamide B13, fluazula B14, fluopicolide B27, zoxamide B31, fluazinam B32, fenpicoxamid B33, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, mefenoxam B46, ethaboxam B56, ethaboxam B58, fludioxonil B65, diethofencarb B73, metrafenone B74, aurobin B78, chlorothalonil B91, prothioconazole B95, fluazinam B116, fluoxapiproline B117, polyoxin B124, kasugamycin B129, zineb B134, mancozeb B135, metiram B136, propineb B137, captan B147, chlorothalonil B149, zineb B159, oxine-copper B160, picarbutrazox B163, aminopyrifen B164, metyltetraprole B165.

[0087] Particular way:

[0088] The active ingredient or composition is dissolved in acetone (the volume ratio of acetone to spray liquid is equal to or less than 0.05), diluted with water containing 0.1% Tween 80 to the desired concentration, and another test solution of the composition is prepared according to the set ratio. The test solution is sprayed on the uniform host plants (not inoculated and not treated with other drugs before spraying) in the greenhouse on a crop spraying machine, and inoculation is performed 24 hours later. According to the characteristics of the disease, the disease plants that need to be cultured in a controlled temperature and humidity environment are inoculated and placed in a climate chamber for culture after the disease has completed the infection, and then moved to the greenhouse for culture; the disease plants that do not need to be cultured in a humidity environment are inoculated and directly moved to the greenhouse for culture. After the control is fully diseased, the disease investigation is carried out, and the total leaf number, diseased leaf number and disease level number are recorded.

[0089] Disease grading method:

[0090] 0 level: no disease on the whole plant;

[0091] 1 level: the area of disease spots is less than 5% of the whole leaf area;

[0092] 3 level: the area of disease spots is 6-10% of the whole leaf area;

[0093] 5 level: the area of disease spots is 11-20% of the whole leaf area;

[0094] 7 level: the area of disease spots is 21-50% of the whole leaf area;

[0095] 9 level: the area of disease spots is more than 51% of the whole leaf area.

[0096] Observed efficacy of active ingredient or composition (C obs ) is calculated using the commonly used formula for pesticide efficacy evaluation (correction formula for calculating control effect):

[0097]

[0098] The efficacy is "0" when the infection level of the treated crop is the same as that of the untreated control; the efficacy is "100" when the treated crop is not infected.

[0099] Expected efficacy of composition (C exp ) is determined using the Abbott method (see Liu Xue-min et al., Synergistic effect of fungicide mixtures, Pesticide Science and Management, 2002, 23(5), 12-15).

[0100] C exp = X + Y - XY / 100

[0101] In the formula:

[0102] X: the efficacy of active ingredient A at a concentration of a;

[0103] Y: the efficacy of active ingredient B at the concentration of b.

[0104] The synergism of the composition is evaluated by the ratio of observed efficacy (C obs ) and expected efficacy (C exp ). When the ratio (synergistic ratio) > 1, the composition shows synergistic effect; when the ratio (synergistic ratio) = 1, the composition shows additive effect; when the ratio (synergistic ratio) < 1, the composition shows antagonistic effect.

[0105] Example 1 Test 1 for controlling cucumber powdery mildew

[0106] The two-leaf stage cucumber seedlings of variety "Jinren-4" were treated with the aqueous solution of each active ingredient or the composition (the effective ingredient concentration is described in the following table) by spraying, 24 hours later, the powdery mildew spores were sprayed on the leaves by a sprayer, and cultured in a greenhouse, after 10 days when the control was fully diseased, the disease investigation was carried out.

[0107] The activity data and synergism of each single active ingredient and the composition of the present application for controlling cucumber powdery mildew are shown in Table 1 and Table 2.

[0108] The results of Table 2 below show that the ratio of observed efficacy (C obs ) and expected efficacy (C exp ) of the composition are all > 1, which indicates that the composition shows synergistic effect on cucumber powdery mildew within the test ratio range.

[0109] Table 1 Activity of single active ingredient

[0110]

[0111] Table 2 Activity and synergism of the composition of the present application

[0112]

[0113]

[0114] Example 2 Test 2 for controlling cucumber powdery mildew

[0115] The two-leaf stage cucumber seedlings of variety "Xintai Mici" were treated with the aqueous solution of each active ingredient or the composition (the effective ingredient concentration is described in the following table) by spraying, 24 hours later, the powdery mildew spores were sprayed on the leaves by a sprayer, and cultured in a greenhouse, after 10 days when the control was fully diseased, the disease investigation was carried out.

[0116] The activity data and synergism of each single active ingredient and the composition of the present application for controlling cucumber powdery mildew are shown in Table 3 and Table 4.

[0117] The results of Table 4 below show that the ratio of observed efficacy (C obsthe ratio of observed efficacy (C exp ) and expected efficacy (C obs ) is >1, which indicates that the composition has a synergistic effect on cucumber powdery mildew within the test ratio range.

[0118] Activity of individual active ingredients

[0119]

[0120]

[0121] Activity and synergistic effect of the composition of the present application

[0122]

[0123]

[0124] Prevention and treatment of muskmelon powdery mildew

[0125] The potted four-leaf muskmelon seedlings (1-2 leaves were removed before the test, and only 3-4 leaves were reserved) of the variety "Honey Sweet Melon" were treated with an aqueous solution (concentration as described in the following table) of each active ingredient or composition, and 24 hours later, the muskmelon powdery mildew spore suspension was inoculated on the leaves, and cultured in a greenhouse, and after 15 days of full disease of the control, the disease investigation was carried out.

[0126] The activity data of each individual active ingredient of the present application for preventing and treating muskmelon powdery mildew are shown in Table 5.

[0127] The activity data and synergistic effect of the composition of the present application for preventing and treating muskmelon powdery mildew are shown in Table 6.

[0128] The results of the following Table 6 show that the ratio of observed efficacy (C obs ) and expected efficacy (C exp ) is >1, which indicates that the composition has a synergistic effect on muskmelon powdery mildew within the test ratio range.

[0129] Activity of individual active ingredients

[0130]

[0131]

[0132] Activity and synergistic effect of the composition of the present application

[0133]

[0134] Prevention and treatment of muskmelon powdery mildew

[0135] The pepper seedlings of six-leaf stage of variety "Qing Yuanjiao" were treated with the water solution of each active component or composition (the effective component concentration was described in the following table) by spraying, 24 hours later, the pepper powdery mildew spores were inoculated on the back of the leaves, and were cultured in a climate room, after the disease completed the infection, were moved into a greenhouse for culture, after 20-25 days, the disease investigation was carried out after the control was fully diseased.

[0136] The activity data of each single active component of the present application for preventing and treating pepper powdery mildew were shown in table 7 and table 8.

[0137] The activity data and synergistic effect of the composition of the present application for preventing and treating pepper powdery mildew were shown in table 9 and table 10.

[0138] The results of the following table 9 and table 10 showed that the ratio of the observed efficacy (C obs ) and the expected efficacy (C exp ) of the composition was >1, which indicated that the composition showed synergistic effect on the pepper powdery mildew in the test ratio range.

[0139] Table 7 activity of single active component

[0140]

[0141] Table 8 activity of single active component

[0142]

[0143] Table 9 activity and synergistic effect of the composition of the present application

[0144]

[0145] Table 10 activity and synergistic effect of the composition of the present application

[0146]

[0147] Example 5 test for preventing and treating bean powdery mildew

[0148] The bean seedlings of two-leaf stage of variety "Fengshou No.1" were treated with the water solution of each active component or composition (the effective component concentration was described in the following table) by spraying, after the spraying, were naturally dried, 24 hours later, the bean powdery mildew pathogen spore water suspension (5×10 6 / m1) was inoculated on the bean leaves, after natural drying, were moved into a greenhouse for culture, the culture condition (temperature: day 23-28℃, night 18-20℃), the disease investigation was carried out after the control was fully diseased.

[0149] The activity data of each single active component of the present application for preventing and treating bean powdery mildew were shown in table 11.

[0150] The activity data and synergistic effect of the composition of the present application on controlling white powdery disease of kidney bean are shown in Table 12.

[0151] The results shown in Table 12 below show that the ratio of observed efficacy (C obs ) and expected efficacy (C exp ) of the composition is >1, indicating that the composition has a synergistic effect on white powdery disease of kidney bean within the test ratio range.

[0152] Activity of individual active ingredient

[0153]

[0154] Activity and synergistic effect of the composition of the present application

[0155]

[0156] Example 6 Test for controlling white powdery disease of tobacco

[0157] Pot-grown tobacco seedlings of variety "CN89" at six-leaf stage were treated with an aqueous solution of each active ingredient or composition (concentration as shown in the table below) by spraying, and 24 hours later, a spore suspension of tobacco powdery mildew was inoculated on the leaves of the tobacco seedlings, which were then moved into a greenhouse for cultivation. After 20 days, the disease condition was investigated after the control was fully infected.

[0158] The activity data of each individual active ingredient of the present application on controlling white powdery disease of tobacco are shown in Table 13.

[0159] The activity data and synergistic effect of the composition of the present application on controlling white powdery disease of tobacco are shown in Table 14.

[0160] The results shown in Table 14 below show that the ratio of observed efficacy (C obs ) and expected efficacy (C exp ) of the composition is >1, indicating that the composition has a synergistic effect on white powdery disease of tobacco within the test ratio range.

[0161] Activity of individual active ingredient

[0162]

[0163]

[0164] Activity and synergistic effect of the composition of the present application

[0165]

[0166] Example 7 Test for controlling rust of corn

[0167] The two-leaf stage corn seedlings of variety "Jin Huang Nu" were treated with the active components or the aqueous solution of the composition (the effective component concentration is described in the following table) by spraying, 24 hours later, the corn rust spore suspension was inoculated on the corn leaves, and was cultured in a climate chamber, after the disease completed infection, was moved into a greenhouse for culture, after 7 days, the control was fully diseased, and the disease investigation was carried out.

[0168] The activity data of the individual active components of the present application for preventing and treating corn rust are shown in Table 15.

[0169] The activity data and synergistic effect of the composition of the present application for preventing and treating corn rust are shown in Table 16.

[0170] The results of the following Table 16 show that the ratio of the observed efficacy (C obs ) and the expected efficacy (C exp ) of the composition is greater than 1, which indicates that the composition shows a synergistic effect on corn rust within the test ratio range.

[0171] Activity of individual active components in Table 15

[0172]

[0173] Activity and synergistic effect of the composition of the present application in Table 16

[0174]

[0175]

[0176] Example 8 Test 1 for preventing and treating cucumber downy mildew

[0177] The two-leaf stage cucumber seedlings of variety "Xin Tai Mi Ci" were treated with the active components or the aqueous solution of the composition (the effective component concentration is described in the following table) by spraying, 24 hours later, the cucumber downy mildew spore cyst suspension was inoculated on the cucumber leaves, and was cultured in a climate chamber, after the disease completed infection, was moved into a greenhouse for culture, after 7 days, the control was fully diseased, and the disease investigation was carried out.

[0178] The activity data of the individual active components of the present application for preventing and treating cucumber downy mildew are shown in Table 17.

[0179] The activity data and synergistic effect of the composition of the present application for preventing and treating cucumber downy mildew are shown in Table 18.

[0180] The results of the following Table 18 show that the ratio of the observed efficacy (C

[0181] Activity of individual active components in Table 17

[0182]

[0183]

[0184] Table 18 Activity and synergism of the composition of the present application

[0185]

[0186]

[0187]

[0188] Example 9 Test 2 for controlling cucumber downy mildew

[0189] The two-leaf stage cucumber seedlings of the variety "Xintai Moci" were treated by spraying with the aqueous solutions of the active ingredients or the compositions (the effective ingredient concentrations are described in the following table), 24 hours later, the cucumber downy mildew pathogen spore suspension was inoculated on the cucumber leaves, and was cultured in a climate chamber, after the disease completed the infection, it was moved into a greenhouse for culture, after 7 days, the disease investigation was carried out after the control was fully diseased.

[0190] The activity data of the individual active ingredients of the present application for controlling cucumber downy mildew are shown in Table 19.

[0191] The activity data and synergism of the composition of the present application for controlling cucumber downy mildew are shown in Table 20.

[0192] The results of the following Table 20 show that the ratio of the observed efficacy (Cobs) and the expected efficacy (Cexp) of the composition is greater than 1, which indicates that the composition shows a synergistic effect on cucumber downy mildew within the test ratio range.

[0193] Table 19 Activity of the individual active ingredients

[0194]

[0195] Table 20 Activity and synergism of the composition of the present application

[0196]

[0197]

[0198]

[0199] Example 10 Test 3 for controlling cucumber downy mildew

[0200] The experiment was performed according to the related content of national standard GB / T 17980.26-2000: Pesticide Field Efficacy Test Guidelines (I)-fungicide control of cucumber downy mildew. The test site was set in the protected field of Baying Town, Sujiatun District, Shenyang City, and the cucumber variety was Xintai Mici. The cucumber was in the fruiting stage, and the downy mildew occurred slightly. The area of each plot was about 25m 2 ; the cucumber was sprayed with the active ingredient according to the test dosage; the test was performed for 2 times, and the interval was 7 days. Ten days after the second spraying, the downy mildew of cucumber in each plot was investigated. Eight plants were selected from each plot, and the disease of the whole plant was investigated from top to bottom.

[0201] The activity data of each single active ingredient of the present application for controlling cucumber downy mildew are shown in Table 21.

[0202] The activity data and synergistic effect of the composition of the present application for controlling cucumber downy mildew are shown in Table 22.

[0203] The results of Table 22 show that the ratio of observed efficacy (Cobs) and expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on cucumber downy mildew within the test ratio range.

[0204] Activity of single active ingredient

[0205]

[0206] Activity and synergistic effect of the composition of the present application

[0207] Example 11 Test 4 for controlling cucumber downy mildew

[0208] The pot-cultured two-leaf cucumber seedlings of the variety "Xintai Mici" were sprayed with the aqueous solution of each active ingredient or composition (the effective ingredient concentration is shown in the following table), and 24 hours later, the cucumber downy mildew pathogen spore suspension was inoculated on the cucumber leaves, and then cultured in a climate room. After the disease completed the infection, it was moved to a greenhouse for culture. After 7 days, the disease investigation was performed after the control was fully diseased.

[0209] The activity data of each single active ingredient of the present application for controlling cucumber downy mildew are shown in Table 23.

[0210] The activity data and synergistic effect of the composition of the present application for controlling cucumber downy mildew are shown in Table 24.

[0211] The results of Table 24 show that the ratio of observed efficacy (Cobs) and expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on cucumber downy mildew within the test ratio range.

[0212] Activity of single active ingredient

[0213]

[0214] Activity and synergism of the compositions of the present application

[0215]

[0216]

[0217] Example 12 Test 1 for controlling grape downy mildew

[0218] The potted grape seedlings of variety "White Heart" at five-leaf stage were treated with the aqueous solutions of each active ingredient or composition (the effective ingredient concentration was described in the following table), 24 hours later, the grape downy mildew pathogenic spore suspension was inoculated on the grape leaves, and the grape seedlings were placed in a climate chamber for culture, after the disease completed infection, they were moved into a greenhouse for culture, and after 7 days, the disease investigation was carried out after the control was fully diseased.

[0219] The activity data of each single active ingredient of the present application for controlling grape downy mildew were shown in Table 25.

[0220] The activity data and synergism of the compositions of the present application for controlling grape downy mildew were shown in Table 26.

[0221] The results of the following Table 26 showed that the ratio of observed efficacy (Cobs) and expected efficacy (Cexp) of the composition were both greater than 1, which indicated that the composition showed synergistic effect on grape downy mildew within the test ratio range.

[0222] Activity of the single active ingredient

[0223]

[0224]

[0225] Activity and synergism of the compositions of the present application

[0226]

[0227]

[0228] Example 13 Test 2 for controlling grape downy mildew

[0229] The potted grape seedlings of variety "White Heart" at five-leaf stage were treated with the aqueous solutions of each active ingredient or composition (the effective ingredient concentration was described in the following table), 24 hours later, the grape downy mildew pathogenic spore suspension was inoculated on the grape leaves, and the grape seedlings were placed in a climate chamber for culture, after the disease completed infection, they were moved into a greenhouse for culture, and after 7 days, the disease investigation was carried out after the control was fully diseased.

[0230] The activity data of each individual active ingredient of the present application against grape downy mildew are shown in Table 27.

[0231] The activity data and synergism of the composition of the present application against grape downy mildew are shown in Table 28.

[0232] The results shown in Table 28 below show that the ratio of observed efficacy (Cobs) to expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition exhibits a synergistic effect against grape downy mildew within the range of the tested ratios.

[0233] Activity of individual active ingredients

[0234]

[0235] Activity and synergism of the composition of the present application

[0236]

[0237]

[0238] Example 14 Test 3 for controlling grape downy mildew

[0239] Potted grape seedlings of the variety "White Heart" at the five-leaf stage were treated with an aqueous solution of each active ingredient or composition (the concentration of the active ingredient is described in the table below) by spraying, and 24 hours later, the grape downy mildew pathogen spore suspension was inoculated on the grape leaves, and the grape seedlings were placed in a climate chamber for cultivation, and after the disease completed the infection, they were moved to a greenhouse for cultivation, and after 7 days, the disease investigation was carried out after the control was fully diseased.

[0240] The activity data of each individual active ingredient of the present application against grape downy mildew are shown in Table 29.

[0241] The activity data and synergism of the composition of the present application against grape downy mildew are shown in Table 30.

[0242] The results shown in Table 30 below show that the ratio of observed efficacy (Cobs) to expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition exhibits a synergistic effect against grape downy mildew within the range of the tested ratios.

[0243] Activity of individual active ingredients

[0244]

[0245] Activity and synergism of the composition of the present application

[0246]

[0247]

[0248] Example 15 Test 4 for controlling grape downy mildew

[0249] The potted grape seedlings of variety "White Heart" at five-leaf stage were sprayed with the aqueous solutions of each active ingredient or composition (the effective ingredient concentration was described in the following table), 24 hours later, the grape downy mildew pathogen spore suspension was inoculated on the grape leaves, and the grape seedlings were placed in a climate chamber for cultivation, after the disease completed infection, they were moved into a greenhouse for cultivation, and after 7 days when the control was fully diseased, the disease investigation was carried out.

[0250] The activity data of each individual active ingredient of the present application for controlling grape downy mildew are shown in Table 31.

[0251] The activity data and synergistic effect of the composition of the present application for controlling grape downy mildew are shown in Table 32.

[0252] The results of the following Table 32 show that the ratio of observed efficacy (Cobs) and expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition shows a synergistic effect on grape downy mildew within the test ratio range.

[0253] Table 31 Activity of individual active ingredient

[0254]

[0255]

[0256] Table 32 Activity and synergistic effect of the composition of the present application

[0257]

[0258]

[0259] Example 16 Test for controlling cabbage downy mildew

[0260] The potted cabbage seedlings of variety "Four Seasons Small Cabbage" at five-leaf stage were sprayed with the aqueous solutions of each active ingredient or composition (the effective ingredient concentration was described in the following table), 24 hours later, the cabbage downy mildew spore suspension was inoculated on the leaf back, and cultivated in a climate chamber, after the disease completed infection, they were moved into a greenhouse for cultivation, and after 5-7 days when the control was fully diseased, the disease investigation was carried out.

[0261] The activity data of each individual active ingredient of the present application for controlling cabbage downy mildew are shown in Table 33.

[0262] The activity data and synergistic effect of the composition of the present application for controlling cabbage downy mildew are shown in Table 34.

[0263] The results of the following Table 34 show that the ratio of observed efficacy (C obs ) and expected efficacy (Cexp The ratio of the observed efficacy (C obs ) to the expected efficacy (C exp ) of each composition is greater than 1, indicating that the composition has a synergistic effect on the control of cucumber downy mildew within the test ratio range.

[0264] Activity of individual active ingredients

[0265]

[0266]

[0267] Activity and synergistic effect of the composition of the present application

[0268]

[0269] Example 17 Test for controlling sunflower downy mildew

[0270] Sunflower seedlings of variety "Sandow" at six-leaf stage (1-4 leaves were removed before the test, and only 5-6 leaves were reserved) were treated with an aqueous solution of each active ingredient or composition (the concentration of active ingredient is shown in the table below) by spraying, 24 hours later, the sunflower downy mildew spore suspension was inoculated on the leaves, and was cultured in a climate chamber, and then was moved into a greenhouse after the disease completed the infection, and the disease investigation was carried out after 12 days when the control was fully diseased.

[0271] The activity data of each individual active ingredient of the present application for controlling sunflower downy mildew are shown in Table 35.

[0272] The activity data and synergistic effect of the composition of the present application for controlling sunflower downy mildew are shown in Table 36.

[0273] The results of Table 36 below show that the ratio of the observed efficacy (C obs ) to the expected efficacy (C exp ) of each composition is greater than 1, indicating that the composition has a synergistic effect on the control of sunflower downy mildew within the test ratio range.

[0274] Activity of individual active ingredients

[0275]

[0276] Activity and synergistic effect of the composition of the present application

[0277]

[0278]

[0279] Example 18 Test for controlling tomato late blight 1

[0280] Tomato seedlings of cultivar "Fentaro" at five-leaf stage were sprayed with each active ingredient or the aqueous solution of the composition (the concentration of active ingredient was shown in the following table), 24 hours later, the sporangia suspension of the pathogen of tomato late blight was inoculated on the leaves of the tomato seedlings, and the tomato seedlings were placed in a climate chamber for culture, after the disease completed infection, they were moved into a greenhouse for culture, and after 7 days when the control was fully diseased, the disease investigation was carried out.

[0281] The activity data of each single active ingredient of the present application for preventing and treating tomato late blight were shown in Table 37.

[0282] The activity data and synergistic effect of the composition of the present application for preventing and treating tomato late blight were shown in Table 38.

[0283] The results of Table 38 showed that the ratio of observed efficacy (Cobs) and expected efficacy (Cexp) of the composition was greater than 1, which indicated that the composition showed synergistic effect on tomato late blight within the test ratio range.

[0284] Activity of single active ingredient

[0285]

[0286] Activity and synergistic effect of the composition of the present application

[0287]

[0288] Example 19 Test 2 for preventing and treating tomato late blight

[0289] Tomato seedlings of cultivar "Fentaro" at five-leaf stage were sprayed with each active ingredient or the aqueous solution of the composition (the concentration of active ingredient was shown in the following table), 24 hours later, the sporangia suspension of the pathogen of tomato late blight was inoculated on the leaves of the tomato seedlings, and the tomato seedlings were placed in a climate chamber for culture, after the disease completed infection, they were moved into a greenhouse for culture, and after 7 days when the control was fully diseased, the disease investigation was carried out.

[0290] The activity data of each single active ingredient of the present application for preventing and treating tomato late blight were shown in Table 39.

[0291] The activity data and synergistic effect of the composition of the present application for preventing and treating tomato late blight were shown in Table 40.

[0292] The results of Table 40 showed that the ratio of observed efficacy (Cobs) and expected efficacy (Cexp) of the composition was greater than 1, which indicated that the composition showed synergistic effect on tomato late blight within the test ratio range.

[0293] Activity of single active ingredient

[0294]

[0295] Table 40 Activity and synergism of the composition of the present application

[0296]

[0297]

[0298] Example 20 Test 1 for controlling cucumber anthracnose

[0299] The potted two-leaf stage cucumber seedlings of the variety "Xintai Moci" were treated with the aqueous solution of each active ingredient or composition, and naturally air-dried after spraying. After 24 hours, the cucumber anthracnose pathogen spore suspension was inoculated on the cucumber leaves, and cultured in a climate room. After the disease completed infection, it was moved into a greenhouse for culture. After 7 days, the disease investigation was carried out. The leaves were classified according to the development degree of the pathogen infection on the leaves, and the total number of leaves, the number of diseased leaves and the number of disease grades were recorded. The efficacy of the agent was calculated according to the formula.

[0300] The activity data of each individual active ingredient of the present application for controlling cucumber anthracnose are shown in Table 41.

[0301] The activity data and synergism of the composition of the present application for controlling cucumber anthracnose are shown in Table 42.

[0302] The results of the following Table 42 show that the ratio of the observed efficacy (Cobs) and the expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on cucumber anthracnose within the test ratio range.

[0303] Table 41 Activity of individual active ingredient

[0304]

[0305] Table 42 Activity and synergism of the composition of the present application

[0306]

[0307] Example 21 Test 2 for controlling cucumber anthracnose

[0308] The potted two-leaf stage cucumber seedlings of the variety "Xintai Moci" were treated with the aqueous solution of each active ingredient or composition, and naturally air-dried after spraying. After 24 hours, the cucumber anthracnose pathogen spore suspension was inoculated on the cucumber leaves, and cultured in a climate room. After the disease completed infection, it was moved into a greenhouse for culture. After 7 days, the disease investigation was carried out. The leaves were classified according to the development degree of the pathogen infection on the leaves, and the total number of leaves, the number of diseased leaves and the number of disease grades were recorded. The efficacy of the agent was calculated according to the formula.

[0309] The activity data of each individual active ingredient of the present application for controlling cucumber anthracnose are shown in Table 43.

[0310] The activity data and synergistic effect of the composition of the present application on cucumber anthracnose are shown in Table 44.

[0311] The results shown in Table 44 below show that the ratio of observed efficacy (Cobs) and expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on cucumber anthracnose within the test ratio range.

[0312] Activity of individual active ingredients

[0313]

[0314] Activity and synergistic effect of the composition of the present application

[0315]

[0316] Example 22 Test for controlling pepper anthracnose

[0317] Potted pepper seedlings of variety "Qingyuanjiao" at six-leaf stage were treated with an aqueous solution of each active ingredient or composition (the effective ingredient concentration is described in the table below), and 24 hours later, pepper anthracnose spore suspension was inoculated on the back of the leaves, and cultured in a climate chamber, and then moved to a greenhouse for culture after the disease completed infection. After 5-7 days, the disease investigation was carried out after the control was fully diseased.

[0318] The activity data of each individual active ingredient of the present application for controlling pepper anthracnose are shown in Table 45.

[0319] The activity data and synergistic effect of the composition of the present application on cucumber anthracnose are shown in Table 44.

[0320] The results shown in Table 46 below show that the ratio of observed efficacy (C obs ) and expected efficacy (C exp ) of the composition is greater than 1, indicating that the composition has a synergistic effect on cucumber anthracnose within the test ratio range.

[0321] Activity of individual active ingredients

[0322]

[0323] Activity and synergistic effect of the composition of the present application

[0324]

[0325]

[0326] Example 23 Test for controlling eggplant brown spot

[0327] The eggplant seedlings of "Liaoqie No. 1" at five-leaf stage were treated with the water solution of each active component or composition (concentration as shown in the following table) by spraying, 24 hours later, the spore suspension of Alternaria solani was inoculated on the leaves of eggplant, and cultured in a climate room, after the disease completed infection, it was moved into a greenhouse for culture, after 10 days, the disease investigation was carried out after the control was fully diseased.

[0328] The activity data of each single active component of the present application for preventing and treating eggplant brown spot are shown in table 47.

[0329] The activity data and synergistic effect of the composition of the present application for preventing and treating eggplant brown spot are shown in table 48.

[0330] The results of the following table 48 show that the ratio of observed efficacy (C obs ) and expected efficacy (C exp ) of the composition is greater than 1, which indicates that the composition shows synergistic effect on eggplant brown spot within the test ratio range.

[0331] Activity of single active component

[0332]

[0333]

[0334] Activity and synergistic effect of the composition of the present application

[0335]

[0336]

[0337] Example 24 Test for preventing and treating eggplant Alternaria leaf spot

[0338] The eggplant seedlings of "Liaoqie No. 1" at five-leaf stage were treated with the water solution of each active component or composition (concentration as shown in the following table) by spraying, 24 hours later, the spore suspension of Alternaria solani was inoculated on the leaves of eggplant, and cultured in a climate room, after the disease completed infection, it was moved into a greenhouse for culture, after 10 days, the disease investigation was carried out after the control was fully diseased.

[0339] The activity data of each single active component of the present application for preventing and treating eggplant brown spot are shown in table 47.

[0340] The activity data and synergistic effect of the composition of the present application for preventing and treating eggplant brown spot are shown in table 48.

[0341] The results of the following table 48 show that the ratio of observed efficacy (C obs ) and expected efficacy (C exp ) of the composition is greater than 1, which indicates that the composition shows synergistic effect on eggplant brown spot within the test ratio range.

[0342] Activity of individual active ingredients

[0343]

[0344] Activity and synergism of the compositions of the present application

[0345]

[0346]

[0347]

[0348] Example 25 Test for controlling Alternaria black spot of pear

[0349] The tender leaves of potted seedlings of the variety "Shangli" were surface sterilized, washed with sterile water and dried in the shade. The leaves were treated by immersion in an aqueous solution of the active ingredient or composition (concentrations as indicated in the tables below) and, after 24 hours, inoculated with a spore suspension of Alternaria alternata and incubated in Petri dishes containing 2% water agar under constant temperature and light. After 14 days, when the control plants were fully diseased, the disease was assessed.

[0350] The activity of the individual active ingredients of the present application for controlling Alternaria black spot of pear is shown in Table 51.

[0351] The activity and synergism of the compositions of the present application for controlling Alternaria black spot of pear is shown in Table 52.

[0352] The results shown in Table 52 below show that the ratio of observed efficacy (C obs ) to expected efficacy (C exp ) for the compositions is >1, indicating that the compositions exhibit a synergistic effect for controlling Alternaria black spot of pear in the range of concentrations tested.

[0353] Activity of individual active ingredients

[0354]

[0355]

[0356] Activity and synergism of the compositions of the present application

[0357]

[0358] Example 26 Test for controlling leaf spot of peanuts 1

[0359] The two pairs of potted peanut seedlings of variety "Baisha" at flat-leaf stage were treated with the aqueous solution of each active component or composition (the concentration is described in the following table) by spraying, 24 hours later, peanut brown blight spore suspension was inoculated on the leaves, and was cultured in a climate chamber, after the disease completed infection, was moved into a greenhouse for culture, after 10-12 days, the disease investigation was carried out after the control was fully diseased.

[0360] The activity data of each single active component of the present application for preventing and treating peanut leaf spot are shown in Table 53.

[0361] The activity data and synergistic effect of the composition of the present application for preventing and treating peanut leaf spot are shown in Table 54.

[0362] The results of the following Table 54 show that the ratio of observed efficacy (C obs ) and expected efficacy (C exp ) of the composition is >1, which indicates that the composition shows a synergistic effect on peanut leaf spot within the test ratio range.

[0363] Activity of single active component

[0364]

[0365]

[0366] Activity and synergistic effect of the composition of the present application

[0367]

[0368] Example 27 Test 2 for preventing and treating peanut leaf spot

[0369] The two pairs of potted peanut seedlings of variety "Baisha" at flat-leaf stage were treated with the aqueous solution of each active component or composition (the concentration is described in the following table) by spraying, 24 hours later, peanut brown blight spore suspension was inoculated on the leaves, and was cultured in a climate chamber, after the disease completed infection, was moved into a greenhouse for culture, after 10-12 days, the disease investigation was carried out after the control was fully diseased.

[0370] The activity data of each single active component of the present application for preventing and treating peanut leaf spot are shown in Table 55.

[0371] The activity data and synergistic effect of the composition of the present application for preventing and treating peanut leaf spot are shown in Table 56.

[0372] The results of the following Table 56 show that the ratio of observed efficacy (C obs ) and expected efficacy (C exp ) of the composition is >1, which indicates that the composition shows a synergistic effect on peanut leaf spot within the test ratio range.

[0373] Activity of single active component

[0374]

[0375] Activity and synergism of the compositions of the present application

[0376]

[0377] Example 28 Test for controlling wheat scab

[0378] The potted two-leaf stage wheat seedlings of the variety "Liaochun 18" were sprayed with the aqueous solutions of the active ingredients or the compositions (concentrations as described in the following table), and after 24 hours, the spore suspension of the wheat scab fungus was inoculated on the leaves and cultured in a greenhouse. After 5 days, the disease investigation was carried out after the control was fully diseased.

[0379] The activity data of the individual active ingredients of the present application for controlling wheat scab are shown in Table 57.

[0380] The activity data and synergism of the compositions of the present application for controlling wheat scab are shown in Table 58.

[0381] The results shown in the following Table 58 show that the ratio of the observed efficacy (C obs ) and the expected efficacy (C exp ) of the compositions is > 1, indicating that the compositions show a synergistic effect on wheat scab within the test ratio range.

[0382] Activity of the individual active ingredients

[0383]

[0384] Activity and synergism of the compositions of the present application

[0385]

[0386]

[0387] Example 29 Test 1 for controlling rice sheath blight

[0388] The potted two-leaf stage rice seedlings of the variety "Longdao 18" were sprayed with the aqueous solutions of the active ingredients or the compositions (concentrations as described in the following table), and after 24 hours, the mycelial suspension of the rice sheath blight fungus was inoculated on the rice leaves and cultured in a greenhouse. After 5 days, the disease investigation was carried out after the control was fully diseased.

[0389] The activity data of the individual active ingredients of the present application for controlling rice sheath blight are shown in Table 59.

[0390] The activity data and synergism of the compositions of the present application for controlling rice sheath blight are shown in Table 60.

[0391] The results in Table 60 below show that the ratio of observed efficacy (C obs ) to expected efficacy (C exp ) of the compositions are both >1, indicating that the compositions exhibit a synergistic effect on rice sheath blight within the test ratio range.

[0392] Activity of individual active ingredients

[0393]

[0394] Activity and synergism of the compositions of the present application

[0395]

[0396]

[0397] Example 30 Test 2 for controlling rice sheath blight

[0398] Potted rice seedlings of variety "Longdao 18" at the two-leaf stage were treated with an aqueous solution (concentration as described in the table below) of each active ingredient or composition, and 24 hours later, a mycelial suspension of the rice sheath blight fungus was inoculated on the rice leaves and incubated in a greenhouse. After 5 days, when the controls were fully diseased, the disease was investigated.

[0399] The activity data of each individual active ingredient of the present application for controlling rice sheath blight are shown in Table 61.

[0400] The activity data and synergism of the compositions of the present application for controlling rice sheath blight are shown in Table 62.

[0401] The results in Table 62 below show that the ratio of observed efficacy (C obs ) to expected efficacy (C exp ) of the compositions are both >1, indicating that the compositions exhibit a synergistic effect on rice sheath blight within the test ratio range.

[0402] Activity of individual active ingredients

[0403]

[0404]

[0405] Activity and synergism of the compositions of the present application

[0406]

[0407] Example 31 Test for controlling rice bacterial leaf blight

[0408] Rice (variety: Koshihikari) was planted in the same pots in a greenhouse at 8 plants per pot, and when grown to the four-leaf stage, was sprayed with an aqueous solution of each active ingredient or composition, and after 24 hours, the activated Xanthomonas oryzae pv. oryzae strain was uniformly sprayed on the rice leaves, and after artificial air preservation for 24 hours, was moved to a greenhouse for further cultivation. After the water control had fully developed the disease, the length of the leaf lesion of each treatment was measured, and the disease inhibition rate, i.e., the observed efficacy, was calculated by the following formula.

[0409]

[0410] The activity data of each individual active ingredient of the present application for controlling rice bacterial leaf blight are shown in Table 63.

[0411] The activity data and synergistic effect of the composition of the present application for controlling rice bacterial leaf blight are shown in Table 64.

[0412] The results of Table 64 below show that the ratio of the observed efficacy (C obs ) to the expected efficacy (C exp ) of the composition is >1, indicating that the composition has a synergistic effect on rice bacterial leaf blight within the range of the tested ratios.

[0413] Activity of individual active ingredients

[0414]

[0415] Activity and synergistic effect of the composition of the present application

[0416]

[0417]

[0418] Example 32 Treatment test for pepper anthracnose

[0419] Potted pepper seedlings of the variety "Aoyumianjo" at the six-leaf stage were inoculated with a pepper anthracnose spore suspension, and were cultivated in a climate chamber, and after 24 hours, were sprayed with an aqueous solution of each active ingredient or composition (the effective ingredient concentration is described in the following table), and were then moved to a greenhouse for cultivation, and after 5-7 days, when the control had fully developed the disease, the disease condition was investigated.

[0420] The treatment activity data of each individual active ingredient and composition of the present application for pepper anthracnose are shown in Tables 65 and 66.

[0421] The results of Tables 65 and 66 below show that the ratio of the observed efficacy (C obs ) to the expected efficacy (C exp ) of the composition is >1, indicating that the composition has a synergistic effect on pepper anthracnose within the range of the tested ratios.

[0422] Table 65 Therapeutic effects of active ingredients and synergistic effects of compositions

[0423]

[0424] Table 66 Therapeutic effects of active ingredients and synergistic effects of compositions

[0425]

[0426]

[0427] Example 33 Persistence test for preventing and treating pepper powdery mildew

[0428] The potted pepper seedlings of the variety "Qingyuanjiao" were treated with an aqueous solution of each active ingredient or composition (the effective ingredient concentration is described in the following table) by spraying, and after 1 day, 3 days, 5 days, 7 days and 10 days, the pepper powdery mildew spores were sprayed on the back of the leaves by an inoculator, and cultured in a greenhouse. After 20-25 days when the control was fully diseased, the disease investigation was carried out.

[0429] The activity data of each single active ingredient and the composition of the present application for preventing and treating pepper powdery mildew are shown in Table 67.

[0430] The results of the following Table 67 show that the observed efficacy of the single components and the composition of the present application for pepper powdery mildew gradually decreases with the extension of the inoculation time after treatment. At the same concentration, the observed efficacy of the single components is 50% lower when inoculated 5 days after treatment, and the observed efficacy of the composition is higher than 60%. When inoculated 10 days after treatment, the observed efficacy of the single components is not obvious, and the observed efficacy of the composition is about 30%, showing obvious control effect. It is shown that the single components of the present application used in the form of composition enhance the persistent activity of the agents for pepper powdery mildew.

[0431] Table 67 Persistent activity of active ingredients and synergistic effects

[0432]

[0433]

[0434] Example 34 Field test for preventing and treating cucumber powdery mildew

[0435] In the sunlight greenhouse, the cucumber (variety "Shuiguohuanggu") was treated with an aqueous solution of each active ingredient or composition (the concentration is described in the following table) by spraying at the medium stage of powdery mildew, and after 15 days, the disease investigation was carried out.

[0436] The activity data of each single active ingredient of the present application for preventing and treating cucumber powdery mildew are shown in Table 68.

[0437] The activity data and synergistic effects of the composition of the present application for preventing and treating cucumber powdery mildew are shown in Table 69.

[0438] The results of Table 69 show that the ratio of observed efficacy (C obs ) to expected efficacy (C exp ) of the compositions is >1, which means that the compositions show a synergistic effect on cucumber powdery mildew in the test ratio range.

[0439] Activity of the individual active ingredients

[0440]

[0441] Activity and synergism of the compositions according to the application

[0442]

Claims

1. A bactericidal composition, characterized in that: The composition comprises two active components, A and B, wherein the weight ratio between active component A and active component B is 1:50-50:1; Wherein, the active component A is a compound represented by the general formula IA or its sulfate; ； Where: R3 is selected from hydrogen; R4 and R5 are each selected from hydrogen; R6 and R7 are each selected from hydrogen; R8 and R9 are each selected from hydrogen; R 11 Selected from 4-chloro; R 14 、R 15 、R 16 or R 17 are respectively selected from hydrogen; W is selected from hydrogen; n is 1; The active component B is selected from ethidol sulfonate B56 or ethidol B58.

2. The bactericidal composition according to claim 1, wherein: The composition comprises active component A and active component B in a weight ratio of 1:20-20:

1.

3. The bactericidal composition according to claim 2, characterized in that: The composition comprises active component A and active component B in a weight ratio of 1:10-10:

1.

4. A use of the bactericidal composition according to claim 1, characterized in that: The fungicidal composition is used to prepare a medicament for preventing and treating plant pathogenic fungal diseases; The plant pathogenic fungal disease is plant powdery mildew.

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