A hypoallergenic exfoliating composition, an exfoliating cosmetic and its preparation method

Abstract

This application relates to the technical field of cosmetics, specifically disclosing a hypoallergenic exfoliating composition, an exfoliating cosmetic, and a method for preparing the same. The hypoallergenic exfoliating composition includes a core material and a wall material coating the outer surface of the core material; the core material is a fruit acid, and the raw materials for preparing the wall material include xanthan gum and layered silicate minerals. This hypoallergenic exfoliating composition can be added to aqueous solutions, emulsions, creams, and gels, and has advantages such as strong exfoliation effect, low irritation, and the ability to reduce allergic symptoms such as skin inflammation.

Description

Technical Field

[0001] This application relates to the technical field of cosmetics, and more specifically, to a hypoallergenic exfoliating composition, an exfoliating cosmetic, and a method for preparing the same. Background Technology

[0002] Body lotion is a skin care lotion applied to the body. It is usually applied to the skin after bathing and forms a film on the skin's surface to lock in moisture and reduce skin moisture loss, thus moisturizing the skin and reducing dryness and peeling.

[0003] The normal skin renewal cycle is generally 28 days. However, due to environmental factors or other factors, too many dead skin cells accumulate on the skin surface, which can burden the skin and cause roughness, dullness, or spots. Therefore, it is necessary to regularly remove dead skin cells, accelerate skin metabolism, promote the absorption of active ingredients, and increase the skin's radiance and elasticity.

[0004] Currently, there are two main methods for exfoliation: physical and chemical. Physical methods remove dead skin cells through physical friction, but they are highly irritating and can damage the skin's stratum corneum, ultimately causing adverse effects such as redness and inflammation. Chemical methods involve adding acids such as fruit acids to exfoliate, but fruit acids are also highly irritating, leading to problems such as burning, redness, and inflammation. Summary of the Invention

[0005] To reduce the irritation of fruit acids and thus gently remove excess keratin from the skin, reducing the burning, redness, and inflammation that easily occur with exfoliating body lotions, this application provides a hypoallergenic exfoliating composition, an exfoliating cosmetic, and a method for preparing the same.

[0006] In a first aspect, this application provides a hypoallergenic exfoliating composition, which adopts the following technical solution:

[0007] A hypoallergenic exfoliating composition includes a core material and a wall material covering the outer surface of the core material; the core material is fruit acid, and the raw materials for preparing the wall material include xanthan gum and layered silicate minerals.

[0008] By adopting the above technical solution, layered silicate minerals and xanthan gum form a special layered hydrogel that encapsulates fruit acid, fixing the fruit acid between the layers. This not only increases the contact time between the fruit acid and the skin, improving the skin's exfoliation properties and thus enhancing the exfoliation effect, but also reduces the direct stimulation of the fruit acid on the skin, alleviates long-term irritation, and reduces allergic symptoms such as skin inflammation.

[0009] An emulsion was prepared by adding the above exfoliating composition to cosmetics. The emulsion underwent performance testing, revealing a skin scaling index change rate of 86.19% and an erythema index of 15.11%. When the composition did not contain xanthan gum and layered silicate minerals, the skin scaling index change rate was 86.19% and the erythema index was 19.64%. When the composition did not contain sodium magnesium silicate, the skin scaling index change rate was 62.98% and the erythema index was 19.08%. A higher skin scaling index indicates a better exfoliating effect, while a lower erythema index indicates lower irritation. Therefore, the comparison shows that the exfoliating composition prepared by encapsulating lactic acid with xanthan gum and layered silicate minerals can be incorporated into the emulsion, resulting in a superior exfoliating effect and lower irritation.

[0010] Optionally, the layered silicate mineral is one or both of sodium magnesium silicate and aluminum magnesium silicate.

[0011] By employing the above technical solution: Sodium magnesium silicate is a layered silicate mineral formed by a periodic arrangement of silicon-oxygen tetrahedra and magnesium-oxygen octahedra along the Z-axis at a ratio of 2:1. Aluminum magnesium silicate is a silicate mineral formed by two layers of silicon-oxygen tetrahedra sandwiching one layer of aluminum-oxygen or magnesium-oxygen octahedra; both can be used to prepare layered hydrogels when compounded with xanthan gum. However, aluminum magnesium silicate is slightly less effective than sodium magnesium silicate, making sodium magnesium silicate more suitable for this composition.

[0012] Optionally, the weight ratio of xanthan gum to layered silicate minerals is (0.3-0.5):(2-3).

[0013] By adopting the above technical solution, when the weight ratio of xanthan gum to layered silicate minerals is within the above range, the resulting colloidal state is better, the coating effect on fruit acids is better, and it is beneficial to reduce the irritation of fruit acids.

[0014] Optionally, the fruit acid is composed of glycolic acid, gluconolactone, and lactobionic acid, wherein the weight ratio of glycolic acid, gluconolactone, and lactobionic acid is (2-4):(1-2):(1-2).

[0015] By employing the above-mentioned technical solution, glycolic acid, being the smallest molecular weight fruit acid, more easily penetrates the epidermis to reach the dermis, thus possessing extremely strong transdermal penetration. It can also disrupt the desmosomes of epidermal keratinocytes, weakening the connections between cells, promoting the loosening and shedding of epidermal keratinocytes, and encouraging new cells to replace old cells, achieving skin rejuvenation, fading of pigmentation, reduction of dullness, and overall beautifying effects. It is particularly effective at loosening and shedding keratinized cells around hair follicles.

[0016] Gluconolactone is a non-toxic, naturally occurring multihydroxy acid in the skin. Due to its large molecular weight, it penetrates the skin relatively slowly, allowing for a gentler exfoliating effect. Because of its multihydroxy structure, it also possesses some moisturizing properties.

[0017] Lactobionic acid is a multihydroxy acid containing a gluconic acid structure and a galactose structure. It has strong moisturizing properties and can effectively soften and remove dead skin cells, dissolving excess dirt and dead skin cells in the stratum corneum, making the skin more delicate and radiant.

[0018] This application has discovered a certain synergistic effect among the three components, resulting in an exfoliating composition that is significantly more effective than the combination of two fruit acids.

[0019] Optionally, the fruit acid is composed of glycolic acid, gluconolactone, and lactobionic acid, wherein the weight ratio of glycolic acid, gluconolactone, and lactobionic acid is 3:1.5:1.5.

[0020] Secondly, this application provides an exfoliating cosmetic product, which adopts the following technical solution:

[0021] An exfoliating cosmetic product includes the aforementioned hypoallergenic exfoliating composition and cosmetic excipients, wherein the amount of the hypoallergenic exfoliating composition added to the cosmetic product is 21.9-25.9%.

[0022] By adopting the above technical solution: a certain amount of water is used in the preparation process of the hypoallergenic exfoliating composition for dissolution and dilution, and the concentration of fruit acid is appropriately reduced. When the amount of hypoallergenic exfoliating composition added is within the above range, the cosmetic product has better exfoliating performance and lower irritation, and can achieve gentle and effective removal of dead skin cells. Optionally, the cosmetic product is one of water, lotion, cream, or gel.

[0023] By adopting the above technical solution, the hypoallergenic exfoliating composition, with its stable and gentle properties, can be used in mainstream products on the market, including water-based, lotion, cream, and gel products, and has a wide range of applications.

[0024] Optionally, the cosmetic is an emulsion, and the cosmetic excipients include: water, niacinamide, aloe vera leaf juice, caprylic / capric triglyceride, panthenol, glycerin, shea butter, glyceryl stearate se, sodium hydroxide, stearyl alcohol, p-hydroxyacetophenone, 1,2-hexanediol, polyethylene glycol / stearate, glyceryl stearate, allantoin, citrus fruit extract, dipotassium glycyrrhizate, and tocopheryl acetate.

[0025] By adopting the above technical solution, citrus fruit extract can inhibit the activation and expression of TRPV-1 in keratinocytes, thereby reducing the production of keratin.

[0026] Dipotassium glycyrrhizate can inhibit LPS-induced production of TNF-α, IL-1β and PGE2, and weaken LPS-induced TLR4 expression and NF-κB activation.

[0027] Panthenol can reduce PGE2 release induced by a combination of inflammatory factors by 30%, and promote epithelial cell formation and skin regeneration.

[0028] Niacinamide can increase the content of ceramides and free fatty acids on the skin surface and reduce transdermal water loss in TEWL (TEWL).

[0029] Aloe vera leaf juice contains abundant lignin and minerals, both of which have excellent permeability and moisturizing properties.

[0030] A synergistic effect was found between citrus fruit extract, dipotassium glycyrrhizate, panthenol, niacinamide, and aloe vera leaf juice, which can significantly reduce the irritation caused by fruit acids and improve the increase in TEWL caused by the removal of the stratum corneum, resulting in cosmetics with lower irritation and better moisturizing effect.

[0031] Shea butter can form a soft film on the surface of the skin after exfoliation, protecting the skin and further reducing the amount of TEWL.

[0032] Thirdly, this application provides a method for preparing an exfoliating cosmetic, which adopts the following technical solution:

[0033] A method for preparing an exfoliating cosmetic includes the following steps:

[0034] S1. Mix water, nicotinamide, aloe vera (ALOE BARBADENSIS) leaf juice, glycerin, p-hydroxyacetophenone, allantoin, and dipotassium glycyrrhizate to obtain mixture A; mix caprylic / capric triglyceride, Butyrospermum Parkii fruit oil, glyceryl stearate SE, stearyl alcohol, polyethylene glycol stearate, glyceryl stearate, and tocopheryl acetate to obtain mixture B;

[0035] S2. Heat mixture A to 70-80℃, stir and mix, then cool to 40-45℃, add the hypoallergenic exfoliating composition, panthenol, sodium hydroxide, 1,2-hexanediol, and citrus (CITRUS RETICULATA) fruit extract, stir and mix, and cool to obtain the final product.

[0036] By adopting the above technical solution: mixing aqueous phase substances to obtain mixture a, and mixing oil phase substances to obtain mixture b, the components in the aqueous phase are uniform and the components in the oil phase are uniform. Then, by blending and achieving full emulsification of the two, the resulting cosmetic has uniform components, high overall stability and is not prone to separation. Then, a low-allergenic exfoliating composition is added, so that the resulting cosmetic has a gentle and powerful exfoliating effect.

[0037] In summary, this application has the following beneficial effects:

[0038] 1. This application uses xanthan gum and layered silicate minerals to form a special layered hydrogel, which encapsulates fruit acid between the layers. This not only reduces the direct and long-term irritation of fruit acid to the skin, reducing skin redness and inflammation, but also extends the continuous contact time of fruit acid with the skin, improving the effect of removing excess keratin, thus achieving a gentle exfoliation effect.

[0039] 2. In this application, glycolic acid, gluconolactone, and lactobionic acid are used in combination. Due to the synergistic effect among the three, the ability to remove excess keratin is improved.

[0040] 3. In this application, the addition of citrus fruit extract, dipotassium glycyrrhizate, panthenol, nicotinamide, and aloe vera leaf juice provides synergistic effects and reduces acute irritation caused by fruit acids. Detailed Implementation

[0041] The present application will be further described in detail below with reference to the embodiments.

[0042] Preparation Examples 1-7

[0043] A hypoallergenic exfoliating composition comprises the components and their corresponding weights as shown in Table 1, and is obtained by adding the components into an emulsifying pot and stirring and mixing at 2000 rpm for 60 min.

[0044] Table 1. Components and their weights (kg) in Preparation Examples 1-7

[0045]

[0046]

[0047] Preparation Example 8

[0048] A hypoallergenic exfoliating composition differs from Preparation Example 1 in that an equal amount of magnesium aluminum silicate is used instead of sodium magnesium silicate.

[0049] Example 1

[0050] An exfoliating cosmetic, specifically a lotion, comprising a hypoallergenic exfoliating composition and cosmetic excipients;

[0051] The components and their corresponding weights of the exfoliating cosmetic are shown in Table 2, and the product was prepared by the following steps:

[0052] S1. Mix water, nicotinamide, glycerin, p-hydroxyacetophenone, and allantoin at 70°C and stir at 500 rpm for 2 hours to obtain mixture A; mix caprylic / capric triglyceride, Butyrospermum Parkii fruit oil, glyceryl stearate SE, stearyl alcohol, PEG-100 stearate, glyceryl stearate, and tocopheryl acetate at 70°C and stir at 500 rpm for 2 hours to obtain mixture B.

[0053] S2. Mixture A and mixture B are stirred and mixed at 70°C and 2500 rpm for 10 min. After naturally cooling to 40°C, add the hypoallergenic exfoliating composition (prepared from Preparation Example 1), sodium hydroxide, and 1,2-hexanediol. Stir and mix, and then naturally cool to 25°C. After degassing and filtration, the product is obtained.

[0054] Glycerin, density 1.263 g / cm³ 3 .

[0055] Table 2. Components and their weights (kg) in Examples 1-3 and Comparative Examples 1-2.

[0056]

[0057]

[0058] Comparative Example 3

[0059] An exfoliating cosmetic, specifically a lotion, differs from Example 1 in that xanthan gum and sodium magnesium silicate are not added during the preparation of the hypoallergenic exfoliating composition, but the amount of the hypoallergenic exfoliating composition used in the lotion remains unchanged.

[0060] Comparative Example 4

[0061] An exfoliating cosmetic, specifically a lotion, differs from Example 1 in that sodium magnesium silicate is not added during the preparation of the hypoallergenic exfoliating composition, but the amount of the hypoallergenic exfoliating composition used in the lotion remains unchanged.

[0062] Examples 4-6

[0063] An exfoliating cosmetic, specifically an emulsion, comprises a hypoallergenic exfoliating composition and cosmetic excipients; the components of the exfoliating cosmetic and their corresponding weights are shown in Table 3, and it is prepared by the following steps:

[0064] S1. Mix water, nicotinamide, aloe vera (ALOE BARBADENSIS) leaf juice, glycerin, p-hydroxyacetophenone, allantoin, and dipotassium glycyrrhizate at 80°C and stir at 500 rpm for 1 hour to obtain mixture A; Mix caprylic / capric triglyceride, Butyrospermum Parkii fruit oil, glyceryl stearate SE, stearyl alcohol, PEG-100 stearate, glyceryl stearate, and tocopheryl acetate at 80°C and stir at 500 rpm for 1 hour to obtain mixture B;

[0065] S2. Mixture A and mixture B at 80°C and 2500 rpm for 5 minutes. After naturally cooling to 45°C, add the hypoallergenic exfoliating composition (prepared from Preparation Example 1), panthenol, sodium hydroxide, 1,2-hexanediol, and citrus fruit extract. Stir and mix, and then naturally cool to 25°C. After degassing and filtration, the product is obtained.

[0066] The leaf juice of Aloe Barbadensis was collected from Wuhan Lvjing Fenghua Biotechnology Co., Ltd., model CB2311; the citrus fruit extract was collected from Baoji Liupanyun Biotechnology Co., Ltd., with a particle size of 100 mesh.

[0067] Table 3. Components and their weights (kg) in Examples 2, 4-6

[0068]

[0069] Examples 7-13

[0070] An exfoliating cosmetic product, which differs from Example 5 in that the use of the hypoallergenic exfoliating composition is detailed in Table 4.

[0071] Table 4. Usage of the hypoallergenic exfoliating compositions in Examples 5 and 7-13

[0072] Example 5 7 8 9 10 11 12 13 Preparation example of hypoallergenic exfoliating composition 1 2 3 4 5 6 7 8

[0073] Performance testing

[0074] The exfoliating cosmetic (lotion) prepared in the examples and comparative examples was used as the test product, and the following performance tests were conducted. The test results are recorded in Table 5.

[0075] Subject requirements: Subjects were selected according to QBT4256-2011.

[0076] Detection methods

[0077] 1. Exfoliation effect test: The subject cleaned the inner forearm of his arm and drew two 3*3cm marks on each side. 2 A square area was designated as the test area. Skin texture was detected within this area using a Visioscan (VC20) skin texture scanner, followed by visual analysis, and recorded as the initial skin scaling value A0. Subjects received (2.0±0.1) mg / cm² daily. 2 Apply the test product to the test area, leave it on for 8 hours, then wash it off. After 14 days, perform visual analysis and record the skin scaling value A1. Calculate the rate of change of skin scaling value between day 14 and day 0 using the following formula. The greater the rate of change, the better the exfoliation effect.

[0078] Calculation formula: A = (A1 - A0) / A0 × 100%.

[0079] 2. Skin irritation test: After the subject cleansed their face, the solution was applied at a concentration of (2.0±0.1) mg / cm³. 2 The test product was applied in a specific amount, and the erythema index of the cheek area was measured three times using a VISIA CR. The average value was taken. The lower the erythema index, the lower the irritation.

[0080] 3. Stratum corneum moisture content test: The subject cleaned the inner forearm of his arm and drew two 3*3cm areas. 2 A square area was designated as the test area. Under constant temperature and humidity conditions (temperature 21±1℃, relative humidity 50±10%), the patient sat still for 30 minutes with the forearm exposed. The stratum corneum moisture content of the test area was measured using a Corneometer CM825 and recorded as the initial moisture content value C1. The moisture content was then measured at (2.0±0.1) mg / cm³ in the test area. 2 Apply the test product to the test area, wash it off after 8 hours, and measure the stratum corneum moisture content of the test area again after 28 days. Record the initial moisture content value C1. Calculate the moisture content change rate C according to the following formula. The larger the change rate, the better the moisturizing effect.

[0081] Calculation formula: C = (C1 - C0) / C0 × 100%.

[0082] 4. Transepidermal water loss: After the subject cleansed their face, the transepidermal water loss (TEWL) value of the cheek area was measured three times in parallel using a transepidermal water loss meter. The average value was taken as the initial TEWL value D0. The dosage was (2.0±0.1) mg / cm³ daily. 2Apply the test product to the specified amount, wash it off after 8 hours, and measure the transepidermal water loss (TEWL) value of the cheek area three times after 14 days. Take the average value as the initial value D1 of TEWL. Calculate the TEWL change rate D according to the following formula. The smaller the change rate, the smaller the transepidermal water loss rate after 14 days and the better the moisturizing effect.

[0083] Calculation formula: D=(D1-D0) / D0×100%.

[0084] Table 5 Performance Test Results

[0085]

[0086] In Example 1, the hypoallergenic exfoliating composition prepared in Preparation Example 1 was used, resulting in a skin scaling index change rate of 86.19% and an erythema index of 15.11%. In Comparative Example 3, the hypoallergenic exfoliating composition did not contain xanthan gum and sodium magnesium silicate (i.e., it only contained fruit acid), resulting in a skin scaling index change rate of 86.19% and an erythema index of 19.64%. In Comparative Example 4, the hypoallergenic exfoliating composition did not contain sodium magnesium silicate, resulting in a skin scaling index change rate of 62.98% and an erythema index of 19.08%.

[0087] This indicates that the combination of sodium magnesium silicate and xanthan gum forms a special layered hydrogel that fixes the fruit acid between the layers. This not only significantly reduces the irritation of the exfoliating composition but also effectively prolongs the contact time between the fruit acid and the skin, resulting in a better exfoliating effect of the cosmetic. However, when sodium magnesium silicate is lacking, the inability to form a layered hydrogel leads to increased irritation and decreased exfoliating effect of the lotion.

[0088] The difference between Examples 2-3, Comparative Examples 1-2 and Example 1 lies in the amount of the hypoallergenic exfoliating composition used in the emulsion. As shown in Table 5, when the amount is within the range of Examples 2-3, the performance of the prepared emulsion is better.

[0089] The difference between Examples 4-6 and Example 2 is that Examples 4-6 use an equal amount of a mixture of citrus fruit extract, dipotassium glycyrrhizate, panthenol, niacinamide, and aloe vera leaf juice instead of niacinamide. Due to the synergistic effect among the citrus fruit extract, dipotassium glycyrrhizate, panthenol, niacinamide, and aloe vera leaf juice, the irritation of fruit acids is reduced. Thus, when combined with the hypoallergenic exfoliating composition, a gentler and more effective exfoliating lotion is obtained.

[0090] The difference between Examples 7-9 and Example 5 is that the ratio of xanthan gum to layered silicate minerals in the hypoallergenic exfoliating composition is different. When the amounts of both are as in Examples 7-9, the resulting emulsion is less irritating.

[0091] The difference between Examples 10-12 and Example 8 is that the fruit acids used in Example 8 are only glycolic acid and gluconolactone, while the fruit acids used in Examples 10-12 are glycolic acid, gluconolactone, and lactobionic acid. Due to the synergistic effect between the three, the exfoliation effect is significantly better than that of a combination of two of the three, and the irritation is not significantly increased, resulting in a better performance of the emulsion.

[0092] The difference between Example 13 and Example 5 is that an equal amount of magnesium aluminum silicate is used instead of sodium magnesium silicate. The exfoliating effect of the emulsion is reduced and the irritation is increased, but the change is not significant and still meets the requirements.

[0093] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. An exfoliating cosmetic product, characterized in that, The product includes a hypoallergenic exfoliating composition and cosmetic excipients, wherein the hypoallergenic exfoliating composition is added in an amount of 21.9-25.9% in the cosmetic. The hypoallergenic exfoliating composition includes a core material and a wall material covering the outer surface of the core material; The core material is fruit acid, which is composed of glycolic acid, gluconolactone, and lactobionic acid, and the weight ratio of glycolic acid, gluconolactone, and lactobionic acid is (2-4):(1-2):(1-2). The raw materials for preparing the wall material include xanthan gum and layered silicate minerals, wherein the weight ratio of xanthan gum to layered silicate minerals is (0.3-0.5):(2-3), and the layered silicate minerals are sodium magnesium silicate, or a mixture of sodium magnesium silicate and aluminum magnesium silicate; Cosmetic excipients include citrus fruit extract, dipotassium glycyrrhizate, panthenol, niacinamide, and aloe vera leaf juice.

2. The exfoliating cosmetic according to claim 1, characterized in that: The fruit acid is composed of glycolic acid, gluconolactone, and lactobionic acid, and the weight ratio of glycolic acid, gluconolactone, and lactobionic acid is 3:1.5:1.

5.

3. The exfoliating cosmetic according to claim 1, characterized in that: The cosmetic product is one of the following: aqueous solution, lotion, cream, or gel.

4. The exfoliating cosmetic according to claim 3, characterized in that: The cosmetic is an emulsion, and the cosmetic excipients include: water, niacinamide, aloe vera leaf juice, caprylic / capric triglyceride, panthenol, glycerin, shea butter, glyceryl stearate (Se), sodium hydroxide, stearyl alcohol, p-hydroxyacetophenone, 1,2-hexanediol, polyethylene glycol / stearate, glyceryl stearate, allantoin, citrus fruit extract, dipotassium glycyrrhizate, and tocopheryl acetate.

5. A method for preparing the exfoliating cosmetic according to claim 4, characterized in that, Includes the following steps: S1. Mix water, nicotinamide, aloe vera (ALOE BARBADENSIS) leaf juice, glycerin, p-hydroxyacetophenone, allantoin, and dipotassium glycyrrhizate to obtain mixture A; mix caprylic / capric triglyceride, Butyrospermum Parkii fruit oil, glyceryl stearate SE, stearyl alcohol, polyethylene glycol stearate, glyceryl stearate, and tocopheryl acetate to obtain mixture B; S2. Heat mixture A to 70-80℃, stir and mix, then cool to 40-45℃, add the hypoallergenic exfoliating composition, panthenol, sodium hydroxide, 1,2-hexanediol, and citrus (CITRUS RETICULATA) fruit extract, stir and mix, and cool to obtain the final product.

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