Blood purification apparatus and storage medium

Abstract

The application discloses a blood purification device and a storage medium. The device comprises a memory and a processor. The memory stores a computer program. The processor executes the computer program and implements the following method: in a blood purification treatment stage, the blood circuit is connected to blood, a first temperature sensor is used to periodically sample the temperature of the replacement fluid at the outlet of the heating cavity to obtain a first sampling temperature; when the absolute value of the difference between the first sampling temperature and a standard temperature is greater than or equal to a first preset temperature and less than a second preset temperature, the heating power of the heating cavity is feedback adjusted according to the standard temperature and the first sampling temperature, and whether the liquid supplement branch has a pipe folding is determined according to the first sampling temperature after the feedback adjustment. The first preset temperature and the second preset temperature are determined according to the standard temperature. In this way, whether the liquid supplement branch has a pipe folding fault can be automatically identified, and the safety of the blood purification device in the liquid supplement step is improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of blood purification, and in particular to a blood purification device and a storage medium. BACKGROUND

[0002] In clinical applications, medical staff needs to realize the blood purification treatment function of a patient through a blood purification device. In the blood purification process, the pre-stored replacement fluid in the replacement fluid bag is output to the blood circuit, which is a liquid supplementing step. The replacement fluid stored in the replacement fluid bag includes substances required by the human body (such as sodium ions, potassium ions, etc.), substances with disease treatment functions, etc. The replacement fluid needs to be heated in the liquid supplementing step. The heated replacement fluid can ensure that the patient is in a safe blood purification treatment environment and has good comfort.

[0003] Therefore, the physical safety of the liquid supplementing branch has an important influence on the liquid supplementing step. The related technology cannot detect the folded tube fault of the liquid supplementing branch, and it is difficult to discover the folded tube fault of the liquid supplementing branch in time by relying on manual detection, thereby reducing the safety of the blood purification device in the liquid supplementing step. SUMMARY

[0004] Therefore, the physical safety of the liquid supplementing branch has an important influence on the liquid supplementing step. The related technology cannot detect the folded tube fault of the liquid supplementing branch, and it is difficult to discover the folded tube fault of the liquid supplementing branch in time by relying on manual detection, thereby reducing the safety of the blood purification device in the liquid supplementing step.

[0005] In a first aspect, the present application provides a blood purification device, which comprises a blood circuit, a liquid supplementing branch, a replacement fluid bag, a heating cavity, and a first temperature sensor. The first end of the liquid supplementing branch is connected to the replacement fluid bag, the second end of the liquid supplementing branch is connected to the blood circuit, the heating cavity is arranged on the liquid supplementing branch, and the first temperature sensor is arranged at the outlet of the heating cavity. The blood purification device further comprises a memory and a processor. The memory is used to store a computer program, and the processor is used to execute the computer program and implement the following control method of the blood purification device when executing the computer program.

[0006] In the blood purification treatment stage of the blood purification device, the blood circuit is connected to blood, the first temperature sensor is used to periodically sample the temperature of the replacement fluid at the outlet of the heating cavity to obtain a first sampling temperature.

[0007] When the absolute value of the difference between the first sampling temperature and the preset standard temperature is greater than or equal to a first preset temperature and less than a second preset temperature, the heating power of the heating cavity is feedback adjusted according to the standard temperature and the first sampling temperature, and whether the pipe folding of the liquid supplement branch occurs is determined according to the feedback adjusted first sampling temperature, and the first preset temperature and the second preset temperature are determined according to the standard temperature.

[0008] In a second aspect, the present application also provides a computer readable storage medium, which stores a computer program, and the computer program, when executed by a processor, causes the processor to implement the control method of the blood purification apparatus.

[0009] In the process of heating the replacement fluid, the embodiments of the present application identify the pipe folding scenario of the liquid supplement branch according to the flow state of the pipeline liquid in the heating cavity and the feedback signal of the temperature sensor, and in the process of adjusting the heating power of the heating cavity, the temperature of the heated replacement fluid can reach the user's expected safe temperature range, and the flow state abnormal phenomenon of the replacement fluid can be quickly identified according to the change rule of the replacement fluid temperature in the liquid supplement branch, so as to automatically identify whether the pipe folding fault of the liquid supplement branch occurs, greatly improving the judgment accuracy and sensitivity of the pipe folding fault of the liquid supplement branch, reducing the risk of the replacement fluid during the liquid supplement process, ensuring that the replacement fluid temperature can efficiently and stably reach the user's set standard temperature during the liquid supplement process, and the blood purification apparatus has higher control stability and reliability. BRIEF DESCRIPTION OF DRAWINGS

[0010] Figure 1 is the overall structure schematic diagram of an embodiment of the blood purification apparatus of the present application;

[0011] Figure 2 is the basic working principle schematic diagram of blood purification in an embodiment of the blood purification apparatus of the present application;

[0012] Figure 3 is the detailed schematic diagram of the liquid supplement step in an embodiment of the blood purification apparatus of the present application;

[0013] Figure 4 is the flow schematic diagram of an embodiment of the control method of the blood purification apparatus of the present application;

[0014] Figure 5 is the relationship curve schematic diagram of the standard temperature, the first preset temperature and the second preset temperature in an embodiment of the control method of the blood purification apparatus of the present application;

[0015] Figure 6 is the change curve schematic diagram of the replacement fluid temperature under different working conditions in an embodiment of the control method of the blood purification apparatus of the present application;

[0016] Figure 7 is a schematic diagram of the variation of the substitution fluid temperature and the heating power of the heating chamber with time when the a tube is folded at 25ml / min in an embodiment of the control method of the blood purification apparatus of the present application;

[0017] Figure 8 is a schematic diagram of the variation of the substitution fluid temperature and the heating power of the heating chamber with time when the a tube is folded at 50ml / min in an embodiment of the control method of the blood purification apparatus of the present application.

[0018] Main elements and symbol description:

[0019] 1, blood circuit; 2, blood pump; 3, arterial clamp; 4, heparin pump; 5, blood purification device; 6, heating chamber; 7, substitution fluid branch; 8, peristaltic pump; 9, substitution fluid bag; 10, venous bottle; 11, liquid level detector; 12, bubble detector; 13, blood detector; 14, venous clamp; 15, first temperature sensor; 16, second temperature sensor; 17, third temperature sensor. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are some of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the scope of protection of the present application.

[0021] The flowchart shown in the drawings is only an example and does not necessarily include all the contents and operations / steps, nor does it necessarily be executed in the described order. For example, some operations / steps can be further decomposed, combined or partially merged, so the actual execution order can be changed according to the actual situation.

[0022] The blood purification mode is used to support the function of human organs. The principle of blood purification is that the blood of a patient is led out of the patient's body to a pipeline, passes through a blood purification device, removes specific substances in the blood, adds substances required by the human body to the blood in the pipeline, forms purified blood, and returns the purified blood to the patient's body through the pipeline. According to the specific type of the blood purification device, the blood purification treatment mode can be divided into hemodialysis, hemofiltration, hemoperfusion, plasma exchange, immunoadsorption, etc. The blood purification mode has been widely applied to the clinical treatment process of various diseases, such as acute and chronic renal failure, poisoning and other types of critical patients.

[0023] In clinical application, medical staff needs to realize the blood purification treatment function of a patient through a blood purification apparatus, Figure 1The overall structure of the blood purification device is shown; the blood purification treatment process of the patient can be controlled through the blood purification device; Figure 2 The basic working principle of blood purification is shown, and the pipeline includes: blood circuit 1, blood pump 2, arterial clamp 3, heparin pump 4, blood purifier 5, heating cavity 6, liquid supplement branch 7, peristaltic pump 8, replacement fluid bag 9, venous bottle 10, liquid level detector 11, bubble detector 12, blood detector 13, venous clamp 14. Figure 1 and Figure 2 The blood circuit 1 is used to transport blood, and the blood purifier 5 is connected in series in the blood circuit 1. The blood of the patient is purified through the blood purifier 5, and the blood of the patient circulates in the blood circuit 1. At the same time, during the blood purification process, the replacement fluid in the replacement fluid bag 9 is output to the blood circuit 1, which is a liquid supplement step. The replacement fluid stored in the replacement fluid bag 9 includes substances required by the human body (such as sodium ions, potassium ions, etc.), substances with disease treatment function, etc., and the liquid supplement step is an essential step for the patient to perform blood purification process.

[0024] The replacement fluid bag is usually purchased by medical staff from the external market. Since the replacement fluid needs to be refrigerated to achieve long-term storage and maintain the physiological activity of various substances in the replacement fluid, such as the optimal storage temperature of the replacement fluid bag being 3℃-10℃, when the replacement fluid bag is used to perform the liquid supplement step, the replacement fluid output by the replacement fluid bag is in a low-temperature state. If the replacement fluid is not heated directly and output to the blood circuit, then the low-temperature replacement fluid in the blood circuit will be returned to the patient's body together with the blood, which will cause the patient's body temperature to drop, cause chills, and in severe cases, cause the patient's platelet to decrease, widespread intravascular coagulation, etc. Therefore, heating the replacement fluid in the liquid supplement step is an essential and important step. The heated replacement fluid can ensure that the patient is in a safe blood purification treatment environment and has good comfort.

[0025] In the liquid supplement step, the replacement fluid flows in the liquid supplement branch, and the physical safety of the liquid supplement branch has an important influence on the liquid supplement step. If the liquid supplement branch is bent, it will block the flow of the replacement fluid in the liquid supplement branch. If the bent pipe fault of the liquid supplement branch cannot be handled in time, the heating cavity will continue to heat the replacement fluid in the pipeline. Due to the principle of thermal expansion and contraction, the replacement fluid will continuously expand under heat until the heating cavity will be broken due to excessive expansion.

[0026] The related art can detect the venous pressure through the pressure sensor arranged in the venous bottle, and determine whether the blood circuit is folded according to the venous pressure. However, the folding failure of the replacement liquid branch will not cause a large fluctuation of the venous pressure of the venous bottle, and the folding failure of the replacement liquid branch cannot be identified according to the fluctuation state of the venous pressure of the venous bottle. It is difficult to find the folding failure of the replacement liquid branch in time by relying on manual detection. Once the replacement liquid branch is in a folded state for a long time, the heating cavity will be easily expanded and broken, thereby reducing the safety and stability of the blood purification equipment in the replacement step.

[0027] To solve the above problems, in the process of heating the replacement liquid, the folding scenario of the replacement liquid branch is identified according to the flow state of the pipeline liquid in the heating cavity and the feedback signal of the temperature sensor. In the process of adjusting the heating power of the heating cavity, the temperature of the replacement liquid after heating can reach the user's expected safe temperature range, and the flow state abnormal phenomenon of the replacement liquid can be quickly identified according to the change rule of the replacement liquid temperature in the replacement liquid branch. Therefore, whether the folding failure of the replacement liquid branch is automatically identified, which greatly improves the judgment accuracy and sensitivity of the folding failure of the replacement liquid branch, reduces the risk of the replacement liquid during the replacement, ensures that the temperature of the replacement liquid can efficiently and stably reach the standard temperature set by the user during the replacement process, and the blood purification equipment has higher control stability and reliability.

[0028] To better illustrate the embodiments of the present application, Figure 3 A detailed schematic diagram of the blood purification equipment in the replacement step is shown. In the blood purification process, the replacement liquid branch 7 outputs the replacement liquid to the blood circuit 1, and the heating cavity 6 heats the replacement liquid in the replacement liquid branch 7. The heating of the replacement liquid in the blood purification equipment is an important link, which can ensure that the patient is in a good temperature comfort for blood purification treatment. When the related art adjusts the heating power of the heating cavity, the temperature control process when adjusting the temperature of the replacement liquid, the heating power is gradually increased or a fixed power is directly given for temperature coarse adjustment. This temperature control method is relatively rough, time-consuming and inaccurate, and there is a large error in the heating process of the replacement liquid in the replacement liquid branch.

[0029] It should be noted that, Figure 2 and Figure 3 The shown is only the basic working principle of blood purification, but when the blood purification equipment is applied to different blood purification treatment modes, the blood purification principle diagram of the blood purification equipment will also change; for example, when the blood purification equipment is applied to the hemodialysis treatment mode, the type of the blood purification device will change, and accordingly, the blood purification principle diagram of the blood purification equipment will also change; but no matter what changes the blood purification principle diagram of the blood purification equipment will occur, Figure 2 and Figure 3The blood purification device can be changed on the basis of the above; and since the embodiment of the application mainly lies in the replenishment step of the blood purification device, the specific principle of blood purification treatment of the patient is not described in detail.

[0030] The blood purification device of the embodiment of the application is described in detail below with reference to the drawings.

[0031] In combination with Figures 1 to 3 The blood purification device comprises a blood circuit 1, a replenishment branch 7, a replacement fluid bag 9, a heating cavity 6, and a first temperature sensor 15; the first end of the replenishment branch 7 is connected to the replacement fluid bag 9, the second end of the replenishment branch 7 is connected to the blood circuit 1, the heating cavity 6 is arranged on the replenishment branch 7, and the first temperature sensor 15 is arranged at the outlet of the heating cavity 6.

[0032] The heating cavity has an inlet and an outlet, the replacement fluid connected to the inlet of the heating cavity is unheated replacement fluid, and the replacement fluid output from the outlet of the heating cavity is heated replacement fluid; when the heating cavity is heated, the heat emitted by the heating cavity is transferred to the replacement fluid in the replenishment branch, the first temperature sensor is arranged at the outlet of the heating cavity, and the temperature of the replacement fluid detected by the first temperature sensor is the temperature of the heated replacement fluid.

[0033] When the patient is treated by blood purification, if the replenishment branch does not have a pipe folding failure, the replacement fluid in the replenishment branch is flowing, the unheated replacement fluid is connected to the inlet of the heating cavity, the replacement fluid is heated in the heating cavity, and the heat exchange of the replacement fluid can be calculated according to the heat exchange formula:

[0034] Q=m*Cp*(Tout-Tin)

[0035] Wherein Q is the heat transfer efficiency, that is, the heat flow, m is the mass flow rate of the replacement fluid m=ρ*q (ρ is the density of the replacement fluid, and q is the flow rate of the replacement fluid), Cp is the specific heat capacity of the replacement fluid, Tout is the temperature of the replacement fluid at the outlet of the heating cavity, and Tin is the temperature of the replacement fluid at the inlet of the heating cavity; it should be noted that in clinical application, in the above heat exchange formula, the density of the replacement fluid ρ can be approximated by the density of water, and the specific heat capacity of the replacement fluid Cp can be approximated by the specific heat capacity of water.

[0036] According to the heat exchange formula, under constant power, there is a certain change rule between the flow rate of the liquid supplement branch and the temperature of the displacement liquid at the outlet of the heating cavity, that is, the greater the flow rate of the liquid supplement branch, the smaller the temperature of the displacement liquid at the outlet of the heating cavity. According to the heat exchange formula, when the temperature of the displacement liquid at the inlet of the heating cavity and the temperature of the displacement liquid at the outlet of the heating cavity are known, and the mass flow rate is known, the required heat flow rate can be obtained, and the heat flow rate is in a proportional relationship with the heating power of the heating cavity, that is, P=kQ, P is the heating power of the heating cavity, and k is a preset coefficient between the heat flow rate and the heating power (k is strongly related to the surface area of the heating cavity in contact with the displacement liquid, k is a constant, and k can be obtained in advance after calibration before the blood purification equipment is shipped).

[0037] According to the principle of the above heat exchange formula, the heating power of the heating cavity can be controlled to quickly and accurately make the temperature of the displacement liquid reach the temperature expected by the user.

[0038] It should be particularly pointed out that the heating cavity in the embodiment of the present application only has heating power (the heating principle of the heating cavity is the heating principle of the resistance wire), and once the heating cavity is powered on and operates, the heating cavity will transfer heat to the displacement liquid in the liquid supplement branch. Moreover, during the blood purification treatment stage, the heating cavity is always operating, and the heating cavity will always heat the displacement liquid in the liquid supplement branch. Only when the heating power of the heating cavity changes, the heating temperature of the heating cavity will also change, for example, when the heating power of the heating cavity increases, the heating temperature of the heating cavity will also increase; when the heating power of the heating cavity decreases, the heating temperature of the heating cavity will also decrease.

[0039] The blood purification equipment further comprises a memory and a processor; the memory is used to store a computer program, and the processor is used to execute the computer program and realize the control method of the blood purification equipment as any one of the following.

[0040] As shown in Figure 4 The control method of the blood purification equipment of the embodiment of the present application comprises the following steps:

[0041] Step S101: During the blood purification treatment stage of the blood purification equipment, the blood circuit is connected to blood, the first temperature sensor is used to periodically sample the temperature of the displacement liquid at the outlet of the heating cavity to obtain a first sampling temperature.

[0042] Specifically, the blood purification device is controlled to enter a blood purification treatment phase, the blood circuit is controlled to access blood in the blood purification treatment phase, and blood purification treatment is performed on the blood of the patient, the replacement fluid output branch outputs replacement fluid to the blood circuit, the replacement fluid in the replacement fluid output branch is heated by the heating cavity, and the temperature of the replacement fluid at the outlet of the heating cavity is periodically sampled by the first temperature sensor during the heating process. For example, the sampling period of the first temperature sensor is 1S, and the first temperature sensor samples the temperature of the replacement fluid at the outlet of the heating cavity every 1S to obtain a first sampling temperature, and the first sampling temperature represents the temperature of the replacement fluid output to the blood circuit.

[0043] Step S102: When the absolute value of the difference between the first sampling temperature and the standard temperature is greater than or equal to a first preset temperature and less than a second preset temperature, the heating power of the heating cavity is feedback adjusted according to the standard temperature and the first sampling temperature, and whether the replacement fluid output branch has a pipe folding is determined according to the first sampling temperature after feedback adjustment. The first preset temperature and the second preset temperature are determined according to the standard temperature.

[0044] The standard temperature represents the user's desired temperature of the replacement fluid at the outlet of the heating cavity, wherein the standard temperature belongs to a safe temperature. If the temperature of the replacement fluid after heating is equal to the standard temperature, it indicates that the replacement fluid after heating can meet the safe physiological temperature condition of the patient. For example, the standard temperature is 36.5°C.

[0045] The first preset temperature and the second preset temperature are used to evaluate the deviation from the standard temperature respectively. Once the standard temperature set by the user is determined, the first preset temperature and the second preset temperature can be directly obtained. The standard temperature, the first preset temperature, and the second preset temperature have a corresponding relationship, Figure 5 The corresponding relationship curve between the three is shown in the figure, wherein Figure 5 The corresponding relationship curve in the figure can be obtained by summarizing multiple technical tests, and therefore the specific principle of the corresponding relationship curve in the figure will not be described in detail. Figure 5

[0046] ​When the first preset temperature ≤ |the first sampling temperature - the standard temperature| < the second preset temperature, the temperature of the heated replacement fluid deviates from the user's expected replacement fluid temperature range, but the temperature of the heated replacement fluid is still in a safe state, so the heating power of the heating cavity needs to be adjusted, either reduced or increased. After the replacement fluid in the replacement fluid branch is heated by the heating cavity, the variation law of the first sampling temperature can be used to determine whether the replacement fluid branch has a pipe folding, so that the feedback adjustment of the heating power of the heating cavity can also be used to determine whether the replacement fluid branch has a pipe folding, thereby simplifying the pipe folding fault determination steps of the replacement fluid branch, and facilitating fine adjustment of the temperature of the replacement fluid in the replacement fluid branch to accurately and quickly reach the user's expected replacement fluid temperature range.

[0047] It should be particularly noted that in S101 and S102, the blood circuit is controlled to flow at a preset flow rate.

[0048] In some embodiments, the method can further include the following steps:

[0049] Step S103: When the absolute value of the difference between the first sampling temperature and the pre-set standard temperature is less than the first preset temperature, the blood circuit is controlled to flow at a preset flow rate.

[0050] When |the first sampling temperature - the standard temperature| < the first preset temperature, it indicates that the temperature of the heated replacement fluid meets the patient's safe physiological temperature fluctuation range, the replacement fluid step is in a normal state, the blood circuit continuously flows at a preset flow rate, and the patient receives normal blood purification treatment. The user can also be prompted by issuing a normal state indication signal that the replacement fluid branch is in a normal replacement fluid step.

[0051] Step S104: When the absolute value of the difference between the first sampling temperature and the standard temperature is greater than or equal to the second preset temperature, it is determined that the heating cavity has a heating fault, and a first fault prompt signal is issued.

[0052] When |the first sampling temperature - the standard temperature| ≥ the second preset temperature, the temperature of the heated replacement fluid has exceeded the patient's physiological safe temperature, the temperature of the heated replacement fluid is in an unsafe state, and the temperature of the heated replacement fluid is too high or too low, so feedback adjustment of the heating power of the heating cavity has no practical significance in this case, and a first fault prompt signal (such as an audible and visual fault prompt signal) needs to be issued immediately to prompt the user to handle the heating fault of the heating cavity, so as to promptly eliminate the heating fault of the blood purification device, and the patient can always be in a safe blood purification treatment state.

[0053] In some embodiments, before the blood purification treatment phase of the blood purification device, the step S101 of controlling the blood circuit to access blood can further include the following steps:

[0054] Step S105: pre-flushing the liquid supplement branch, performing a self-check for faults on the heating cavity and the first temperature sensor during the pre-flushing phase, and determining whether the heating cavity and the first temperature sensor have faults; when it is determined that neither the heating cavity nor the first temperature sensor has a fault, controlling the blood purification device to enter the blood purification treatment phase.

[0055] The entire treatment process of the blood purification device can be sequentially divided into a pipe installation phase, a pre-flushing phase, a blood purification treatment phase, and a blood return phase. The pipe installation phase refers to installing all the pipelines (here, the pipelines include the blood circuit, the liquid supplement branch, etc.) of the blood purification device on the shell, and connecting all the pipelines according to a pre-set pipeline connection diagram. The pre-flushing phase refers to flushing the pipelines and the blood purifier of the blood purification device with a pre-flushing liquid to remove impurities and air in the pipelines and the blood purifier, where the pre-flushing liquid can be physiological saline. The blood purification treatment phase refers to performing blood purification treatment on the blood of a patient using the blood purifier. The blood return phase refers to returning all the residual blood in the pipelines and the blood purifier to the patient's body when the patient finishes the blood purification.

[0056] Controlling the blood purification device to enter the pre-flushing phase and flushing the liquid supplement branch with physiological saline, and performing a self-check for faults on the heating cavity and the first temperature sensor during the pre-flushing phase to remove fault states of the heating cavity and the first temperature sensor. For example, the fault states of the heating cavity and the first temperature sensor include physical damage of the heating cavity and temperature detection faults of the first temperature sensor. If it is determined that neither the heating cavity nor the first temperature sensor has a fault during the pre-flushing phase, the heating cavity and the first temperature sensor can be in a normal operating state during the blood purification treatment phase.

[0057] On the contrary, if it is determined that the heating cavity and / or the first temperature sensor has a fault, the heating cavity and the first temperature sensor are checked for faults respectively.

[0058] The embodiment of the application just completes the fault self-checking of the heating cavity and the first temperature sensor in the preflushing stage, so as to exclude the possible faults of the pipeline and the blood purifier in advance, and guarantee the normal heating process of the replacement fluid in the blood purification treatment stage. Moreover, the heating process of the preflushing fluid in the preflushing stage does not have very strict temperature conditions, so the heating process of the heating cavity is controlled just in the preflushing stage to complete the fault detection process of the heating cavity and the first temperature sensor. The embodiment of the application specially sets the fault self-checking step in the preflushing stage of the blood purification device, because the fault self-checking of the heating cavity and the first temperature sensor can be realized in the preflushing stage without interfering with the normal blood purification treatment of the patient, and the safety and convenience of the replacement fluid heating control of the blood purification device are improved.

[0059] In order to better illustrate the above complete steps S101-S105, the specific principle will be illustrated by a specific application scenario.

[0060] The standard temperature set by the user is 35.0℃, and according to the corresponding relationship in the above table, the first preset temperature is 0.5℃ and the second preset temperature is 3℃. Figure 5

[0061] In the blood purification treatment stage, the first temperature sensor samples the temperature of the replacement fluid at the outlet of the heating cavity every 1S to obtain the first sampling temperature. It should be noted that the first sampling temperature in the embodiment of the application is the temperature obtained by the first temperature sensor every 1S, so the first sampling temperature will change in real time with the heating process of the heating cavity, and the first sampling temperature will change with time. For example, when the first temperature sensor regularly samples the temperature of the replacement fluid at the outlet of the heating cavity, the obtained first sampling temperature is 35.1℃, and |35.1℃-35.0℃|=0.1℃<0.5℃, so the temperature of the heated replacement fluid meets the safe physiological temperature fluctuation range of the patient, and an indication signal of the normal state is sent.

[0062] ​For example, when the first temperature sensor regularly samples the temperature of the replacement fluid at the outlet of the heating cavity, the first sampling temperature is 36.0℃, |36.0℃-35.0℃|=1.0℃, 3℃>1.0℃>0.5℃, the temperature of the heated replacement fluid is too high, so the heating power of the heating cavity needs to be reduced. During the process of reducing the heating power of the heating cavity, the first temperature sensor samples the temperature of the replacement fluid at the outlet of the heating cavity every 1S to obtain the first sampling temperature after feedback adjustment. According to the change rule of the first sampling temperature after feedback adjustment, it can be judged whether the replacement fluid branch has a pipe folding. If the replacement fluid branch has a pipe folding or the replacement fluid branch does not have a pipe folding, the change rule of the first sampling temperature will be different. Therefore, the embodiment of the application can finely adjust the temperature of the replacement fluid, so that the temperature of the replacement fluid after feedback adjustment can return to the safe physiological temperature fluctuation range, and whether the replacement fluid branch has a pipe folding can be judged at the same time, thereby improving the replacement safety of the blood purification equipment.

[0063] For example, when the first temperature sensor regularly samples the temperature of the replacement fluid at the outlet of the heating cavity, the first sampling temperature is 31.0℃, |31.0℃-35.0℃|=4.0℃>3℃, the temperature of the heated replacement fluid is too low, and the heated replacement fluid is in an unsafe state. When the heating process of the heating cavity has a heating failure (usually, the heating failure may be that the voltage driving process of the heating cavity is abnormal, or the replacement fluid branch falls off on the heating cavity, etc.), an audible and visual fault prompt signal is immediately sent out to prompt the user.

[0064] In summary, the embodiment of the application finely adjusts the temperature of the replacement fluid in the replacement fluid branch, and simultaneously judges whether the replacement fluid branch has a pipe folding according to the change rule of the first sampling temperature in a timely manner, thereby improving the judgment accuracy and sensitivity of the pipe folding failure of the replacement fluid branch.

[0065] Please refer to Figure 2 and Figure 3 In some embodiments, the blood purification equipment further comprises a peristaltic pump 8 arranged on the replacement fluid branch 7 between the heating cavity 6 and the replacement fluid bag 9. The peristaltic pump 8 provides driving force to the replacement fluid branch 7 by rotating, so that the replacement fluid branch 7 outputs the liquid stored in the replacement fluid bag 9 to the blood circuit 1. The peristaltic pump is a common electronic component in the art, and the control principle of the peristaltic pump is equivalent to the control principle of the motor. The specific control principle of the peristaltic pump will not be described in detail here.

[0066] It should be noted that the liquid stored in the replacement fluid bag is not the same in the pre-flushing stage and the blood purification treatment stage. In the pre-flushing stage, the liquid stored in the replacement fluid bag is pre-flushing fluid; in the blood purification treatment stage, the liquid stored in the replacement fluid bag is replacement fluid.

[0067] At this time, step S105, the pre-flushing of the replacement fluid branch is performed, and the self-failure detection of the heating cavity and the first temperature sensor in the pre-flushing stage is performed to determine whether the heating cavity and the first temperature sensor have failures; when it is determined that the heating cavity and the first temperature sensor do not have failures, the blood purification device is controlled to enter the blood purification treatment stage, and the blood purification device can further include the following sub-steps:

[0068] Sub-step S1051: The peristaltic pump is controlled to operate, so that the replacement fluid branch outputs the pre-flushing fluid to the blood circuit.

[0069] Specifically, when the peristaltic pump operates, the driving force is provided to the replacement fluid branch, and the replacement fluid branch outputs the pre-flushing fluid to the blood circuit at a certain flow rate. The pre-flushing fluid is used to flush the replacement fluid branch, so as to realize the pre-flushing stage of the replacement fluid branch.

[0070] Sub-step S1052: The initial power is determined according to the standard temperature and the preset correspondence relationship, and the heating cavity is controlled to heat the pre-flushing fluid in the replacement fluid branch at the initial power.

[0071] Specifically, the blood purification device includes a display screen. In the pre-flushing stage, the user inputs the standard temperature on the display screen. The preset correspondence relationship represents the correspondence between the temperature and the power. When the initial power of the heating cavity is obtained, the heating cavity is controlled to continuously heat the replacement fluid branch at the initial power in the pre-flushing stage. It should be noted that the initial power of the heating cavity corresponding to the standard temperature according to the preset correspondence relationship is a fixed value. When the heating cavity is controlled to heat the pre-flushing fluid in the replacement fluid branch at the initial power, the self-failure detection of the heating cavity and the first temperature sensor can be completed.

[0072] Sub-step S1053: When the continuous operation time of the peristaltic pump is greater than a first preset time, the first temperature sensor is used to periodically sample the pre-flushing fluid temperature at the outlet of the heating cavity to obtain a second sampling temperature.

[0073] Specifically, when the continuous running time of the peristaltic pump is greater than the first preset time, it is indicated that the pre-liquid has been pre-flushed to the liquid supplement branch for a period of time, and the heating temperature of the heating cavity is in a constant state; because when the peristaltic pump just starts to run (that is, the continuous running time of the peristaltic pump is less than or equal to the first preset time), the heating cavity will go through a preheating stage, and the heating temperature of the heating cavity will gradually rise and then be maintained at a stable state, and the pre-liquid temperature at the outlet of the heating cavity in the preheating stage will also show an upward state; therefore, if the heating cavity and the first temperature sensor are both in a normal state, the second sampling temperature is obtained when the continuous running time of the peristaltic pump is greater than the first preset time, and the second sampling temperature is the pre-liquid temperature after heating and in a stable state.

[0074] Sub-step S1054: When the duration that the second sampling temperature is located in the preset constant temperature range is greater than or equal to the second preset time, determine the temperature difference between the standard temperature and the second sampling temperature.

[0075] Sub-step S1055: When the temperature difference satisfies a first condition, control the blood purification equipment to enter a blood purification treatment stage, and the first condition is that the absolute value of the temperature difference is less than or equal to a third preset temperature.

[0076] The first condition: |standard temperature-second sampling temperature|≤third preset temperature, for example, the third preset temperature is 0.5℃.

[0077] Specifically, the preset constant temperature range is used to judge whether the pre-liquid temperature at the outlet of the heating cavity after heating is in a stable state, when the duration that the second sampling temperature is located in the preset constant temperature range is greater than or equal to the second preset time, it is determined that the pre-liquid temperature at the outlet of the heating cavity after heating is in a stable state, at this time, the temperature difference between the standard temperature and the second sampling temperature is calculated, which represents the deviation degree between the pre-liquid temperature at the outlet of the heating cavity and the standard temperature set by the user. For example, the preset constant temperature range is 16℃-40℃, and the second preset time is 1min, when it is judged that the duration that the second sampling temperature is located in 16℃-40℃ is greater than or equal to 1min, it is determined that the pre-liquid temperature at the outlet of the heating cavity after heating is in a stable state, at this time, the temperature difference between the standard temperature and the second sampling temperature is calculated.

[0078] When the first condition is met, it indicates that the heating cavity heats the preflush liquid in the replacement liquid branch to the user's desired safe physiological temperature fluctuation range within the second preset time, and the first temperature sensor can also detect that the preflush liquid temperature after heating by the heating cavity is in the safe physiological temperature fluctuation range. Therefore, neither the heating cavity nor the first temperature sensor has a fault, and self-checking of the two is successful. Then, the blood purification device is controlled to enter a blood purification treatment stage.

[0079] In some embodiments, the method can further include the following steps:

[0080] Step S106: When the temperature difference meets a second condition, a modified heating power is determined according to the temperature difference, and the heating cavity is controlled to heat the preflush liquid in the replacement liquid branch according to the modified heating power. The second condition is that the absolute value of the temperature difference is greater than the third preset temperature and less than or equal to a fourth preset temperature.

[0081] The second condition is: third preset temperature < | standard temperature-second sampling temperature | ≤ fourth preset temperature. For example, the third preset temperature is 0.5°C, and the fourth preset temperature is 3°C.

[0082] When the second condition is met, it indicates that the heating cavity has not heated the replacement liquid in the replacement liquid branch to the user's desired safe physiological temperature fluctuation range within the standard time. Therefore, the heating power of the heating cavity needs to be adjusted in feedback, and the heating cavity is controlled to continue heating according to the heating power after feedback adjustment, such as increasing or reducing the heating power of the heating cavity, so that the preflush liquid after feedback adjustment can return to the safe physiological temperature fluctuation range.

[0083] Step S107: When the temperature difference meets a third condition, it is determined that the heating cavity and / or the first temperature sensor has a fault. The third condition is that the absolute value of the temperature difference is greater than the fourth preset temperature.

[0084] The third condition is: fourth preset temperature < | standard temperature-second sampling temperature |.

[0085] When the third condition is met, it indicates that the preflush liquid temperature in the replacement liquid branch is too high or too low after the heating cavity heats the preflush liquid within the first preset time, and the temperature of the preflush liquid at this time exceeds the physiological safety temperature of the patient. This indicates that the heating cavity has a fault and / or the first temperature sensor has a fault, such as heating failure of the heating cavity (such as open circuit of the heating wire in the heating cavity) that causes the heating cavity to fail to heat normally, resulting in too low temperature of the preflush liquid after heating, etc. In this case, it is impossible to continue to enter the blood purification treatment stage, and the fault state of the heating cavity and / or the first temperature sensor needs to be investigated and repaired.

[0086] It should be noted that when the second condition is met, although the displacement fluid temperature in the replacement fluid branch does not reach the user's desired safe physiological temperature fluctuation range, this does not exceed the physiological safe temperature of the patient, and after adjusting the heating power of the heating cavity to change the displacement fluid temperature in the replacement fluid branch, this case does not necessarily mean that the heating cavity and / or the first temperature sensor are malfunctioning. Unlike when the third condition is met, the pre-flush fluid temperature at this time exceeds the physiological safe temperature of the patient, and in this case, it can be determined that the heating cavity and / or the first temperature sensor are malfunctioning, which in turn causes the second sampling temperature to deviate significantly from the standard temperature set by the user. Therefore, it is necessary to distinguish between the second condition and the third condition.

[0087] In some embodiments, in step S106, when the temperature difference meets the second condition, the modified heating power is determined according to the temperature difference, which can further include the following steps: obtaining the specific heat capacity of the pre-flush fluid, the density of the pre-flush fluid, the pre-set pre-flush fluid flow rate, and determining the modified heating power according to a first formula, wherein the first formula is: modified heating power = pre-set coefficient * density of pre-flush fluid * specific heat capacity of pre-flush fluid * pre-flush fluid flow rate * (standard temperature - second sampling temperature) + unmodified heating power; wherein the pre-set coefficient is a pre-set value.

[0088] It should be noted that the above-mentioned first formula is derived based on the heat exchange formula in the above, wherein in the clinical application process, the density of the pre-flush fluid can be approximately replaced by the density of water, and the specific heat capacity of the pre-flush fluid can be approximately replaced by the specific heat capacity of water, and the replacement fluid branch will output the pre-flush fluid to the blood circuit according to the pre-flush fluid flow rate set by the user.

[0089] In the first formula, the heating power of the heating cavity before modification refers to the heating power of the heating cavity in the current sampling period of the first temperature sensor; for example, the sampling period of the first temperature sensor is 1S, when it is judged that the duration that the second sampling temperature is in the preset constant temperature range is greater than or equal to the second preset time, at this time, the heating cavity is controlled to heat the preflush liquid in the liquid supplement branch according to the initial power, if the temperature difference between the standard temperature and the second sampling temperature satisfies the second condition, then the heating power of the heating cavity before modification in the first formula is the initial power, for example, the initial power is 100W, after the calculation of the first formula, the modified heating power of the heating cavity is 120W, then the heating cavity is controlled to heat the preflush liquid in the liquid supplement branch according to 120W in the next 1S, after 1S, the first temperature sensor is used again to sample the preflush liquid temperature at the outlet of the heating cavity to obtain the second sampling temperature, if the temperature difference between the standard temperature and the second sampling temperature still satisfies the second condition, the heating power of the heating cavity before modification in the first formula is 120W, after the calculation of the first formula, the modified heating power of the heating cavity is 130W, then the heating cavity is controlled to heat the preflush liquid in the liquid supplement branch according to 130W in the next 1S, and so on.

[0090] It should be noted that when the modified heating power of the heating cavity is calculated according to the first formula, the modified heating power of the heating cavity may be reduced or increased, for example, when the standard temperature is greater than the second sampling temperature, the "standard temperature-second sampling temperature" is a positive value, and then the modified heating power of the heating cavity is increased; for example, when the standard temperature is less than the second sampling temperature, the "standard temperature-second sampling temperature" is a negative value, and then the modified heating power of the heating cavity is reduced.

[0091] In some embodiments, the method can further include the following steps:

[0092] Step S108: When the duration that the second sampling temperature is in the preset constant temperature range is greater than or equal to the second preset time, and it is determined that the actual rotating speed of the peristaltic pump is in a fluctuation state, it is determined that the peristaltic pump is faulty.

[0093] Specifically, when the duration that the second sampling temperature is within the preset constant temperature range is greater than or equal to the second preset time, it indicates that the temperature of the pre-infusion fluid after heating has reached a stable state. In this condition, the pre-infusion fluid flow rate in the liquid supplementing branch needs to be maintained in a stable state in theory. The change state of the pre-infusion fluid flow rate in the liquid supplementing branch is controlled by the peristaltic pump, and the rotational speed of the peristaltic pump is positively correlated with the pre-infusion fluid flow rate in the liquid supplementing branch. Therefore, if the pre-infusion fluid flow rate in the liquid supplementing branch is maintained in a stable state, the actual rotational speed of the peristaltic pump is also necessarily maintained in a stable state. The pre-infusion fluid temperature after heating, the pre-infusion fluid flow rate, and the actual rotational speed of the peristaltic pump have a specific corresponding relationship. When it is determined that the second sampling temperature of the liquid supplementing branch is in a stable state, the actual rotational speed of the peristaltic pump is in a stable state, and it can be determined that the peristaltic pump does not have a fault. Because once the second sampling temperature is in a stable state, the pre-infusion fluid flow rate in the liquid supplementing branch is in a stable state (because only when the pre-infusion fluid flow rate is in a stable state, the pre-infusion fluid temperature in the liquid supplementing branch detected by the first temperature sensor is in a stable state, because flow fluctuation will cause the detection value of the first temperature sensor to fluctuate). Therefore, when it is determined that the pre-infusion fluid flow rate in the liquid supplementing branch is maintained in a stable state, but the actual rotational speed of the peristaltic pump is in a fluctuating state, it indicates that the peristaltic pump has a fault, and the peristaltic pump has lost control over the pre-infusion fluid flow rate in the liquid supplementing branch. This may be that the liquid supplementing branch is not correctly installed on the peristaltic pump, or the liquid supplementing branch falls off the peristaltic pump, etc. Therefore, according to whether the actual rotational speed of the peristaltic pump is in a fluctuating state, the application embodiment can determine whether the peristaltic pump has a fault, which is equivalent to completing a fault self-checking process of the peristaltic pump in the pre-infusion stage. When it is determined that the peristaltic pump has a fault, a third fault indication signal can be sent to prompt the user that the peristaltic pump has a fault, so that the user can immediately deal with the fault state of the peristaltic pump, thereby reducing the risk of the peristaltic pump having a fault in the blood purification treatment stage.

[0094] Referring to Figure 3 In some embodiments, the blood purification apparatus further comprises a second temperature sensor 16, wherein the second temperature sensor 16 is arranged at the inlet of the heating cavity 6.

[0095] At this time, in the substep S1052, the initial power is determined according to the standard temperature and the preset reference relationship, which can further include the following substeps:

[0096] In the substep S10521, the pre-infusion fluid temperature at the inlet of the heating cavity is periodically sampled by the second temperature sensor to obtain a third sampling temperature.

[0097] Sub-step S10522: acquiring the specific heat capacity of the pre-priming liquid, the density of the pre-priming liquid, the pre-priming liquid flow rate, and determining the initial power according to a second formula; wherein the second formula is: initial power = preset coefficient * density of pre-priming liquid * specific heat capacity of pre-priming liquid * pre-priming liquid flow rate * (standard temperature - third sampling temperature).

[0098] In the embodiments of the present application, at the most initial time node in the pre-priming phase, the third sampling temperature represents the pre-priming liquid temperature before heating, so the initial power can be quickly located based on the heat exchange formula. Since the third sampling temperature is equivalent to the pre-priming liquid temperature at the outlet of the heating cavity when the heating power is 0, in the above initial power calculation formula of the heating cavity, the modified heating power of the heating cavity is directly set to 0 by default.

[0099] In some embodiments, the blood purification apparatus further comprises a peristaltic pump arranged on the replacement liquid branch between the heating cavity and the replacement liquid bag; and the method can further comprise the following steps:

[0100] Step S108: in the blood purification treatment phase, using the heating cavity to heat the replacement liquid in the replacement liquid branch, and controlling the peristaltic pump to operate.

[0101] Controlling the peristaltic pump to operate can provide driving force to the replacement liquid branch. In the blood purification treatment phase, blood is transmitted through the blood circuit, the heated replacement liquid is output to the blood circuit through the replacement liquid branch, and the purified blood is returned to the patient's body through the blood circuit, so as to ensure the safety of the patient's blood purification treatment.

[0102] In some embodiments, in step S102, the feedback adjustment of the heating power of the heating cavity according to the standard temperature and the first sampling temperature can further comprise the following sub-steps:

[0103] Sub-step S102A1: acquiring the specific heat capacity of the replacement liquid, the density of the replacement liquid, and the pre-set replacement liquid flow rate, and determining the feedback-adjusted heating power according to a third formula; wherein the third formula is: feedback-adjusted heating power = preset coefficient * density of replacement liquid * specific heat capacity of replacement liquid * replacement liquid flow rate * (standard temperature - first sampling temperature) + heating power before feedback adjustment.

[0104] Sub-step S102A2: controlling the heating cavity to heat the replacement liquid in the replacement liquid branch according to the feedback-adjusted heating power.

[0105] Specifically, in the third formula, the density of the replacement fluid can be approximated by the density of water, and the specific heat capacity of the replacement fluid can be approximated by the specific heat capacity of water. The replacement fluid is output to the blood circuit according to the replacement fluid flow rate set by the user. The specific implementation of the third formula can refer to the specific implementation of the first formula, and the specific implementation of the third formula will not be repeated here.

[0106] It should be particularly pointed out that in the third formula, both the first sampling temperature and the heating power of the heating cavity before feedback adjustment are real-time changing values. For example, the first sampling temperature refers to the replacement fluid temperature at the outlet of the heating cavity detected by the first temperature sensor in each sampling period. The first sampling temperature and the heating power of the heating cavity before feedback adjustment refer to the values at the same time.

[0107] During the blood purification treatment stage, the heating power of the heating cavity can be feedback adjusted so that the replacement fluid temperature after feedback adjustment can reach the user's expected replacement fluid temperature range.

[0108] In some embodiments, in step S102, determining whether the replacement fluid branch has a kink according to the feedback-adjusted first sampling temperature can further include the following sub-step:

[0109] Sub-step S102B1: When the heating cavity is controlled to heat the replacement fluid in the replacement fluid branch according to the feedback-adjusted heating power, and the feedback-adjusted first sampling temperature satisfies a fourth condition, it is determined that the replacement fluid branch has a kink. The fourth condition is that the absolute value of the temperature difference between the standard temperature and the feedback-adjusted first sampling temperature is greater than a sixth preset temperature.

[0110] The fourth condition is that |standard temperature-feedback-adjusted first sampling temperature|> sixth preset temperature, for example, the sixth preset temperature is 3°C.

[0111] When the liquid supplement branch appears a kink, the displacement liquid flow in the liquid supplement branch is sharply reduced or directly 0, but since the artificial cannot find the kink fault of the liquid supplement branch in time, the embodiment of the application will still calculate the feedback adjusted heating power of the heating cavity according to the above-mentioned third formula, and in the above-mentioned third formula, the feedback adjusted heating power of the heating cavity will still be calculated according to the "user set displacement liquid flow" to obtain the feedback adjusted heating power of the heating cavity, but the liquid supplement branch appears a kink, and the power of the heating cavity for heat transfer to the displacement liquid in the liquid supplement branch will be greater, if the feedback adjusted heating power is still calculated according to the "user set displacement liquid flow", and the heating cavity is controlled to heat according to the feedback adjusted heating power, the heating power of the heating cavity rises too fast or falls too fast, which leads to that the temperature of the displacement liquid in the feedback adjusted liquid supplement branch exceeds the physiological safe temperature of the patient, that is, the fourth condition 4 is met.

[0112] The following will be described in detail through a specific example. If the user set standard temperature is 36.0℃, the first sampling temperature at the current time is 34.0℃, and the user sets the displacement liquid flow of the blood purification equipment on the display screen as 10ml / min when the liquid supplement branch does not appear a kink, the liquid supplement branch will output the displacement liquid to the blood circuit at 10ml / min, and the feedback adjusted heating power of the heating cavity is calculated according to the above-mentioned third formula as 100W, so that the heating cavity is controlled to heat the displacement liquid in the liquid supplement branch at 100W, and the temperature of the displacement liquid at the outlet of the heating cavity after heating reaches the user set standard temperature (36.0℃).

[0113] However, if the liquid supplement branch appears a kink, the displacement liquid flow in the liquid supplement branch after the kink is reduced to 0 under the same conditions, this condition does not apply to the above-mentioned third formula, the heating process of the heating cavity to the displacement liquid in the liquid supplement branch is mainly heat conduction, the heating efficiency of the displacement liquid is very high, and the heating power of the heating cavity only needs to be modified as 60W, the heating cavity is controlled to heat the displacement liquid in the liquid supplement branch at 60W, and the temperature of the displacement liquid at the outlet of the heating cavity after heating reaches the user set standard temperature (36.0℃); however, since the artificial does not find that the liquid supplement branch does not appear a kink, the feedback adjusted heating power (100W) of the heating cavity is still calculated according to the user set displacement liquid flow (10ml / min), the heating cavity heats the displacement liquid in the liquid supplement branch at 100W, and the temperature of the displacement liquid at the outlet of the heating cavity after heating will be much higher than the user set standard temperature, that is, the fourth condition is met.

[0114] Therefore, the embodiment of the application can quantitatively judge whether the liquid supplement branch appears a kink by judging whether the first sampling temperature meets the fourth condition.

[0115] Sub-step S102B2: when the first sampling temperature after feedback adjustment satisfies the fifth condition, and the continuous time that the first sampling temperature after feedback adjustment satisfies the fifth condition is greater than or equal to the third preset time, it is determined that the liquid supplementing branch has a pipe folding; wherein the fifth condition is that the absolute value of the temperature difference between the standard temperature and the first sampling temperature after feedback adjustment is greater than a fifth preset temperature and less than or equal to a sixth preset temperature, and the third preset time is n*the sampling period of the first temperature sensor, wherein n is a positive integer greater than 0.

[0116] Sub-step S102B3: when the first sampling temperature after feedback adjustment satisfies the fifth condition, and the continuous time that the first sampling temperature after feedback adjustment satisfies the fifth condition is less than the third preset time, it is determined that the liquid supplementing branch does not have a pipe folding.

[0117] The fifth condition is that the sixth preset temperature is greater than the absolute value of the difference between the standard temperature and the first sampling temperature after feedback adjustment, and is greater than the fifth preset temperature, for example, the sixth preset temperature is 3℃, and the fifth preset temperature is 0.5℃.

[0118] When the first sampling temperature does not satisfy the fourth condition, and the second preset temperature is greater than the absolute value of the difference between the first sampling temperature and the standard temperature and is greater than the first preset temperature, feedback adjustment needs to be performed on the heating power of the heating cavity; the third preset time represents the normal adjustment time of the displacement liquid temperature. If the continuous time of feedback adjustment on the displacement liquid temperature is greater than or equal to the third preset time, the displacement liquid temperature in the liquid supplementing branch still does not return to the safe physiological temperature fluctuation range, which indicates that the efficiency of the displacement liquid temperature adjustment process in the liquid supplementing branch is too low. The cause of the too low efficiency is that the liquid supplementing branch has a pipe folding, which causes a heating failure of the heating cavity. Therefore, the continuous time of feedback adjustment on the displacement liquid temperature can be used to determine whether the liquid supplementing branch has a pipe folding.

[0119] The above feedback adjustment and determination of the liquid supplementing branch are relatively accurate, and a relatively rough method can also be used, for example, the heating power is feedback adjusted, the first sampling temperature after feedback adjustment is detected, and if the first sampling temperature after feedback adjustment cannot be adjusted to a safe temperature range within a certain time, it is determined that the liquid supplementing branch has a pipe folding.

[0120] The following will be described in detail through a specific application scenario. In the blood purification treatment stage, if the sampling period of the heating cavity is 1S, the standard temperature set by the user is: 36.5℃, the first preset temperature is: 0.5℃, the second preset temperature is: 3.0℃; the fifth preset temperature is: 0.5℃, the sixth preset temperature is: 3.0℃; after the first temperature sensor is used to sample the replacement fluid temperature in the replacement fluid branch, the first sampling temperature obtained is: 38.0℃. Then |standard temperature-first sampling temperature| = |36.5℃-38.0℃| = 1.5℃, and the heating power of the heating cavity needs to be feedback adjusted; the following is discussed in two cases:

[0121] 1. If there is no pipe folding in the replacement fluid branch, the feedback adjusted heating power of the heating cavity is calculated according to the third formula, and then the heating cavity is controlled to heat the replacement fluid in the replacement fluid branch according to the feedback adjusted heating power. The temperature of the heated replacement fluid after adjustment will return to the user's expected safe physiological temperature fluctuation range (|standard temperature-first sampling temperature| ≤ 0.5℃) within the third preset time. Once the temperature of the replacement fluid at the outlet of the heating cavity on the replacement fluid branch is adjusted to the safe physiological temperature fluctuation range, the feedback adjustment process of the heating power of the heating cavity will be stopped. The continuous time of feedback adjustment of the heating power of the heating cavity will be less than the third preset time.

[0122] 2. If there is pipe folding in the replacement fluid branch, the feedback adjusted heating power of the heating cavity is calculated according to the third formula. As described above, due to the pipe folding in the replacement fluid branch, the replacement fluid flow in the replacement fluid branch rapidly decreases. Then, based on the third formula, the change range of the heating temperature after adjusting the heating temperature of the heating cavity will be greater than the actual temperature change range required by the replacement fluid. Although the heating power of the heating cavity is feedback adjusted according to the third formula for multiple times, the replacement fluid temperature in the replacement fluid branch still cannot reach the user's expected safe physiological temperature fluctuation range after feedback adjustment of the heating power of the heating cavity. There is a judgment standard for this situation: if the continuous time of feedback adjustment of the replacement fluid temperature is greater than or equal to the third preset time, it is determined that there is pipe folding in the replacement fluid branch. If the continuous time of feedback adjustment of the replacement fluid temperature is less than the third preset time, it is determined that the replacement fluid temperature has returned to the safe physiological temperature fluctuation range within the user's allowable time range after continuous feedback adjustment of the heating power of the heating cavity. It is determined that there is no pipe folding in the replacement fluid branch. However, the continuous time of feedback adjustment of the heating power of the heating cavity is relatively long in this case, but it is still within the third preset time (the third preset time represents the user's allowable time range). This case is that there is no pipe folding.

[0123] It should be noted that the third preset time = n * the sampling period of the first temperature sensor, n is set by the user, for example, n = 5, that is, in 5 sampling periods, the heating cavity is calculated according to the third formula after the feedback adjustment of the heating power, and then the heating cavity is controlled to heat the displacement liquid in the liquid supplement branch, and then in 5 sampling periods, whether the first sampling temperature meets the fourth condition is judged to determine whether the liquid supplement branch appears a folded pipe. It should be noted that in the 5 sampling periods, the first temperature sensor samples the displacement liquid temperature at the outlet of the heating cavity 5 times, and the first sampling temperature is obtained after each sampling, and then the first sampling temperature is substituted into the third formula, and then the heating cavity heats the displacement liquid in the liquid supplement branch according to the recalculated heating power, that is, the first sampling temperature actually changes with the sampling period in the 5 sampling periods. Further, if the liquid supplement branch appears a folded pipe, combined with the analysis process of the third formula above, the heating power change amount of the heating cavity calculated by the third formula will be greater than the actual required heating power of the heating cavity, so that after the heating cavity heats the displacement liquid in the liquid supplement branch according to the calculated heating power, the displacement liquid temperature will rise too fast or fall too fast, and then the adjusted displacement liquid temperature cannot reach the user's expected safe physiological temperature fluctuation range in 5 sampling periods, which is the specific reason why the continuous time of the displacement liquid temperature feedback adjustment can determine whether the liquid supplement branch appears a folded pipe.

[0124] It is explained here that there is a case that "if the feedback adjusted first sampling temperature does not meet the fourth condition, and the continuous time of the feedback adjusted first sampling temperature meeting the fifth condition is less than the third preset time, it is determined that the liquid supplement branch does not appear a folded pipe", here there is a limitation condition: the feedback adjusted first sampling temperature does not meet the fourth condition, which is because once the feedback adjusted first sampling temperature meets the fourth condition in the continuous feedback adjustment process of the displacement liquid temperature, it is actually directly determined that the liquid supplement branch appears a folded pipe.

[0125] In some embodiments, the method can further include the following steps:

[0126] Step S109: detecting the length of the liquid supplement branch.

[0127] Step S110: setting the sampling period of the first temperature sensor according to the length of the liquid supplement branch and the displacement liquid flow.

[0128] Specifically, the sampling period of the first temperature sensor represents the sampling frequency of the first temperature sensor on the displacement fluid temperature. The shorter the sampling period of the first temperature sensor, the higher the sampling frequency of the first temperature sensor on the displacement fluid temperature, and the higher the heating accuracy of the user on the displacement fluid in the liquid supplement branch. According to the length of the liquid supplement branch and the displacement fluid flow rate set by the user, the sampling period of the first temperature sensor is set. Generally, the longer the length of the liquid supplement branch, the longer the time it takes for the pre-flush fluid flow rate in the liquid supplement branch to decrease when the liquid supplement branch is bent, and the smaller the sampling period of the first temperature sensor. The displacement fluid temperature in the liquid supplement branch is sampled more frequently by the first temperature sensor, and the first sampling temperature obtained by the first temperature sensor can accurately determine whether the liquid supplement branch is bent. Similarly, the liquid supplement branch is controlled to flow according to the displacement fluid flow rate set by the user. The larger the displacement fluid flow rate set by the user, the larger the error of the displacement fluid temperature sampling value caused by the displacement fluid flow rate, and the smaller the sampling period of the first temperature sensor. The displacement fluid temperature at the outlet of the heating cavity is sampled more frequently, thereby reducing the error in determining whether the liquid supplement branch is bent.

[0129] Further, after multiple clinical technical tests, it is concluded that the length of the liquid supplement branch, the displacement fluid flow rate set by the user, and the sampling period of the first temperature sensor have a corresponding relationship between the values, which can be referred to Table 1 below.

[0130] Table 1

[0131]

[0132] It should be noted that the corresponding relationship between the values in Table 1 above is a value summarized from multiple clinical technical tests, and therefore the specific source of the corresponding relationship between the values in Table 1 above is not described in detail. For example, when it is detected that the length of the liquid supplement branch is 0.6 m, the displacement fluid flow rate set by the user is 2.0 ml / min, and the corresponding sampling period of the first temperature sensor is 3S according to the corresponding relationship in Table 1 above, the first temperature sensor samples the displacement fluid temperature at the outlet of the heating cavity every 3S to obtain the first sampling temperature. In this way, the sampling period of the first temperature sensor can be set scientifically and reasonably, and the temperature sampling error of the first temperature sensor is reduced.

[0133] For better illustration of the embodiments of the present application, specific experiments are used to illustrate the embodiments of the present application.

[0134] The test data in the experimental verification are as follows: the ambient temperature is 25°C, the actual replacement fluid temperature of the liquid supplement branch at the initial time point of the blood purification treatment stage is 25°C, the user-set standard temperature is 35°C, the replacement fluid in the liquid supplement branch needs to be heated by the heating cavity, and the verification comparison data under the conditions of replacement fluid flow rates of 25 ml / min and 50 ml / min are obtained. In order to simplify the test conditions, the densities of the preflush fluid and the replacement fluid are both set to be 1000 kg / m 3 , the specific heat capacities of the preflush fluid and the replacement fluid are both set to be 4.2*10^3 J / (kg·℃), when the blood purification device enters the initial time point of the blood purification treatment stage, the initial heating power of the heating cavity is 8.75 W at a flow rate of 25 ml / min and 17.5 W at a flow rate of 50 ml / min, the sampling period of the first temperature sensor is 1 s, and n=300; the test results are shown in Table 2.

[0135] Table 2

[0136]

[0137]

[0138] In Table 2, the normal working condition represents that the liquid supplement branch does not have a folded tube, the working condition of “a tube is folded before feedback regulation” represents that the a tube is folded before the blood purification treatment stage, that is, the a tube is folded before continuous feedback regulation of the replacement fluid temperature, and the working condition of “a tube is folded during feedback regulation” represents that the a tube is suddenly folded during the blood purification treatment stage, that is, the a tube is suddenly folded during the continuous feedback regulation of the replacement fluid temperature. The following three conclusions can be drawn from Table 2.

[0139] (1) When the a tube is folded, the replacement fluid temperature deviates from the user's desired temperature change, for example, when the a tube is folded before feedback regulation, the continuous feedback regulation of the replacement fluid temperature of the liquid supplement branch deviates from the user-set standard temperature, and therefore, whether the liquid supplement branch is folded can be identified according to the replacement fluid temperature change of the liquid supplement branch during feedback regulation.

[0140] (2) The working condition of "a tube appears to be folded during feedback regulation" is more likely to cause feedback regulation error of the displacement liquid temperature than the working condition of "a tube appears to be folded before feedback regulation", and the amplitude of the regulation error is also larger, because the change amplitude of the heating power of the heating cavity caused by the a tube appearing to be folded during feedback regulation is larger, and the change amplitude of the displacement liquid temperature after the displacement liquid in the displacement branch is heated by the heating cavity is also larger, and the amplitude of the displacement liquid temperature deviating from the standard temperature set by the user after heating is also larger. On the contrary, if the a tube appears to be folded before feedback regulation, the continuous time of feedback regulation of the heating power of the heating cavity in the folded state is also longer, and the change amplitude of the displacement liquid temperature after heating is also smaller. In the above Table 2, it can be directly seen from the data that after 5 minutes of feedback regulation of the heating power of the heating cavity, 62.3°C (the a tube appears to be folded during feedback regulation) is larger than 56.8°C (the a tube appears to be folded before feedback regulation).

[0141] (3) When the displacement branch does not appear to be folded, after continuous feedback regulation of the heating power of the heating cavity, the temperature of the heated displacement liquid can be quickly close to the edge of the standard temperature, and then fine adjustment is performed to ensure that the temperature of the heated displacement liquid is within the user's expected safe physiological temperature fluctuation range. The feedback regulation process of the displacement liquid temperature has the characteristics of high efficiency, accuracy and stability.

[0142] In order to better reflect the change of the heating power of the heating cavity during the feedback regulation process, the following Table 3 shows the numerical change of the heating power of the heating cavity in the folded state and the normal state.

[0143] Table 3

[0144]

[0145]

[0146] It needs to be particularly pointed out that in Table 3, the first sampling temperature and the heating power of the heating cavity are respectively obtained in the feedback adjustment process at "1S", "2S", "3S", "4S" and "5S". This numerical recording method can more intuitively reflect the change of the heating power of the heating cavity with time. Based on Table 3, it can be concluded that under normal conditions, after the heating cavity heats the replacement fluid in the replacement fluid branch, the temperature of the heated replacement fluid quickly reaches the standard temperature, and after the feedback adjustment of the heating power of the heating cavity, the feedback-adjusted heating power can be maintained in a constant state (8.75). When the a tube appears a tube fold before the feedback adjustment, the feedback-adjusted heating power of the heating cavity is calculated based on the above-mentioned third formula, but due to the existence of the tube fold, the calculated heating power will be much larger than the actual heating power required by the heating cavity. Taking the working condition of "the a tube appears a tube fold before the feedback adjustment" under "25 / 8.75" as an example, during "1S", the feedback-adjusted heating power of the heating cavity calculated based on the above-mentioned third formula is 8.75W, but in fact, since the heating cavity only needs 3.81W to heat the replacement fluid to the standard temperature, the heating cavity heats the replacement fluid branch at 8.75W, and the temperature of the heated replacement fluid is 35.3℃ (since the time of 1S is too short, the difference in the change of the temperature of the replacement fluid will not be too obvious). During "2S", since 35.3℃ is greater than the standard temperature (35.0), the modified heating power of the heating cavity will be 8.225W according to the above-mentioned third formula. The modified heating power is actually decreased, although it is decreased, but 8.225W is still greater than 3.81W, which means that the heating cavity is still transferring heat to the replacement fluid branch. The temperature of the heated replacement fluid will still rise (35.6℃>35.3℃), and according to this process, during "3S", during "4S", and during "5S", the temperature of the heated replacement fluid will show an upward trend, and the feedback-adjusted heating power will show a downward trend. Based on Table 3, it can be explained why the replacement fluid temperature change during the feedback adjustment process can accurately identify whether the replacement fluid branch has a tube fold.

[0147] Figure 6 The change curve of the replacement fluid temperature under different working conditions (including the a tube appears a tube fold at 50ml / min, the a tube appears a tube fold at 25ml / min, the a tube does not appear a tube fold at 25ml / min, and the a tube does not appear a tube fold at 50ml / min) is shown. The a tube represents the replacement fluid pipeline between the heating cavity and the blood circuit. 50ml / min and 25ml / min are respectively the replacement fluid flow. It can be concluded that when the replacement fluid branch has a tube fold, the temperature of the replacement fluid will continuously rise and gradually deviate from the standard temperature with time.

[0148] Figure 7 Fig. 3 shows the curves of the changes of the temperature of the displacement fluid and the heating power of the heating cavity with time when the a tube is kinked at 25 ml / min; Figure 8 Fig. 4 shows the curves of the changes of the temperature of the displacement fluid and the heating power of the heating cavity with time when the a tube is kinked at 50 ml / min; Figure 7 and Figure 8 It can be concluded from the summary that when the displacement fluid branch is kinked, the temperature of the displacement fluid will rise sharply, and since the greater the displacement fluid flow rate, the greater the heating power required, the heating power when the displacement fluid branch is kinked will be greater than the heating power when the displacement fluid flow rate is smaller, so the greater the displacement fluid flow rate, the higher the temperature of the displacement fluid will increase. At the same time, when the displacement fluid branch is kinked, even if the heating power is continuously reduced in the feedback adjustment process, the temperature of the displacement fluid will still rise, and the temperature of the displacement fluid after heating will gradually deviate from the standard temperature set by the user.

[0149] Please refer to Figure 3 In some embodiments, the blood purification apparatus further comprises a peristaltic pump 8 arranged on the displacement fluid branch 7 between the heating cavity 6 and the displacement fluid bag 9; the displacement fluid branch 7 comprises a first branch (i.e. the c tube), a second branch (i.e. the b tube) and a third branch (i.e. the a tube); the first branch (i.e. the c tube) is a pipeline between the displacement fluid bag 9 and the peristaltic pump 8, the second branch (i.e. the b tube) is a pipeline between the peristaltic pump 8 and the heating cavity 6, and the third branch (i.e. the a tube) is a pipeline between the heating cavity 6 and the blood circuit 1. Figure 3 In the above description, the "a tube" refers to the third branch, the "b tube" refers to the second branch, and the "c tube" refers to the first branch.

[0150] At this time, the method can further comprise the following steps:

[0151] Step S111: When it is determined that the displacement fluid branch is kinked, detecting whether the temperature of the displacement fluid in the displacement fluid branch fluctuates; when it is detected that the temperature of the displacement fluid in the displacement fluid branch does not fluctuate, determining that the third branch is kinked; when it is detected that the temperature of the displacement fluid in the displacement fluid branch fluctuates, determining that the first branch and / or the second branch is kinked.

[0152] Specifically, when it is determined that the liquid supplementing branch has a kink, the embodiment of the present application can further distinguish whether the a tube has a kink or the "c tube and / or b tube" has a kink. When the a tube has a kink, the replacement liquid bag will continue to output the replacement liquid to the pipeline in the heating cavity through the c tube and the b tube in the short term. Due to the time delay, the fluctuation of the replacement liquid temperature in the liquid supplementing branch caused by the kink needs a certain time delay, and the replacement liquid temperature in the liquid supplementing branch will remain stable in the short term. Therefore, once the replacement liquid temperature does not fluctuate under the condition of the kink, it can be determined that the a tube has a kink. When the c tube and / or the b tube has a kink, the replacement liquid flow connected to the heating cavity will immediately decrease to 0 or rapidly decrease to a very small value. The replacement liquid flow connected to the heating cavity immediately decreases to 0 or rapidly decreases to a very small value in the short term, the heating efficiency of the heating cavity changes rapidly, and the replacement liquid temperature in the liquid supplementing branch fluctuates in the short term. Therefore, it can be directly determined that the "c tube and / or b tube" has a kink. Therefore, according to whether the replacement liquid temperature fluctuates, the embodiment of the present application directly distinguishes whether the a tube has a kink or the "c tube and / or b tube" has a kink, thereby improving the accuracy of the kink judgment of the liquid supplementing branch.

[0153] It should be noted that the embodiment of the present application determines whether the liquid supplementing branch has a kink, and then detects whether the replacement liquid temperature in the liquid supplementing branch fluctuates. The kink judgment of the liquid supplementing branch is specifically judged by whether the first sampling temperature is in a specific numerical range, and the specific position of the kink of the liquid supplementing branch is judged by whether the replacement liquid temperature fluctuates to determine which part of the liquid supplementing branch has a kink. These are two different judgment methods.

[0154] Specifically, the replacement liquid temperature in the liquid supplementing branch does not fluctuate, specifically: the difference between the maximum value and the minimum value of the replacement liquid temperature in the liquid supplementing branch within a preset time is less than a preset temperature value, then it is determined that the replacement liquid temperature in the liquid supplementing branch does not fluctuate. For example, when the first sampling temperature satisfies the fourth condition, and the temperature difference of the replacement liquid in the liquid supplementing branch within 3s is greater than 2℃ (the preset temperature value is 2℃), it is determined that the first branch and / or the second branch have a kink. When the first sampling temperature satisfies the fourth condition, and the temperature difference of the replacement liquid in the liquid supplementing branch within 3s is less than 2℃ (the preset temperature value is 2℃), it is determined that the third branch has a kink.

[0155] In some embodiments, the method can further include the following steps:

[0156] Step S112: controlling the heating cavity to heat the replacement liquid in the liquid supplementing branch according to the feedback-adjusted heating power. When the feedback-adjusted first sampling temperature satisfies the fourth condition, it is determined that the liquid supplementing branch is completely blocked.

[0157] Step S113: determining that the supplement liquid branch is partially blocked when the first sampling temperature after feedback adjustment satisfies the fifth condition for a continuous time greater than or equal to the third preset time.

[0158] Specifically, the "folding pipe in the supplement liquid branch" can be specifically divided into: complete blockage of the supplement liquid branch and partial blockage of the supplement liquid branch. When the first sampling temperature after feedback adjustment directly exceeds the physiological safety temperature of the patient, it indicates that the folding pipe causes a sharp change in the flow rate of the replacement liquid, and the flow rate of the replacement liquid is directly 0 (i.e., complete blockage of the supplement liquid branch). Then, heating the replacement liquid in the supplement liquid branch by the heating cavity will directly cause a sharp change in the temperature of the replacement liquid. In this case, it is directly determined that the supplement liquid branch is completely blocked.

[0159] After continuous feedback adjustment of the temperature of the replacement liquid in the supplement liquid branch, the temperature of the replacement liquid still cannot return to the safe physiological temperature fluctuation range, which indicates that the folding pipe in the supplement liquid branch causes a change in the flow rate of the replacement liquid. In this case, the replacement liquid in the supplement liquid branch is still in a flowing state, but the heating process of the replacement liquid in the supplement liquid branch by the heating cavity is in a fault state, which causes the change amplitude of the replacement liquid temperature after heating to be unable to meet the actual heating demand of the replacement liquid, and further causes the replacement liquid temperature at the outlet of the heating cavity on the supplement liquid branch to be unable to return to the user's desired safe physiological temperature fluctuation range after continuous feedback adjustment. In this case, it is directly determined that the supplement liquid branch is partially blocked.

[0160] Because the folding pipe in the supplement liquid branch is determined to be "completely blocked" or "partially blocked" according to the change rule of the temperature of the replacement liquid in the supplement liquid branch during feedback adjustment, the folding pipe in the supplement liquid branch can be more accurately determined, the safety of the supplement liquid step of the supplement liquid branch is ensured, and the user has higher processing accuracy and processing rate for the folding pipe fault of the supplement liquid branch.

[0161] Referring to Figure 3 In some embodiments, the blood purification apparatus further includes a third temperature sensor 17 arranged on the blood circuit 1. The third temperature sensor 17 can be arranged on the pipeline between the blood input end of the blood circuit 1 and the connection point between the supplement liquid branch 7 and the blood circuit 1. The blood temperature in the blood circuit 1 is detected by the third temperature sensor 17, and whether the blood flow state in the blood circuit 1 is in a fault state can be identified according to the blood temperature.

[0162] At this time, step S103, when the absolute value of the difference between the first sampling temperature and the pre-set standard temperature is less than the first preset temperature, the blood circuit is controlled to flow at a pre-set flow rate, which can further include the following sub-steps:

[0163] Sub-step S1031: when the absolute value of the difference between the first sampling temperature and the standard temperature is less than the first preset temperature, periodically sampling the blood temperature in the blood circuit by using the third temperature sensor to obtain a fourth sampling temperature.

[0164] Sub-step S1032: when the absolute value of the temperature difference between the first sampling temperature and the fourth sampling temperature is less than a seventh preset temperature, controlling the blood circuit to flow at the preset flow rate, and issuing an indication signal of a normal state.

[0165] Specifically, during the blood purification treatment stage, when the replacement fluid temperature in the fluid supplement branch meets the safe physiological temperature fluctuation range of the patient, it is further needed to judge whether the temperature difference between the replacement fluid temperature in the fluid supplement branch and the blood temperature in the blood circuit is too large. When |first sampling temperature-fourth sampling temperature|<seventh preset temperature, it indicates that the temperature difference between the replacement fluid temperature and the blood temperature is within the temperature error range allowed by the user, and the fluid supplement branch can output the replacement fluid to the blood circuit, the blood in the blood circuit is in a safe flow state, and an indication signal of a normal state is issued. On the contrary, when |first sampling temperature-fourth sampling temperature|≥seventh preset temperature, the temperature difference between the replacement fluid temperature and the blood temperature is too large. If the fluid supplement branch outputs the replacement fluid to the blood circuit in this case, the replacement fluid temperature and the blood temperature differ too much, and the addition of the replacement fluid will cause the blood temperature in the blood circuit to suddenly increase or suddenly decrease, which will lead to abnormal changes in the blood temperature in the blood circuit, the blood temperature in the blood circuit being too high or too low, and even the blood temperature in the blood circuit exceeding the safe temperature range of the blood of the user. In this case, an indication signal of a normal state is not issued.

[0166] Therefore, the embodiments of the present application not only sample the replacement fluid temperature by using the first temperature sensor to judge whether the replacement fluid temperature in the fluid supplement branch is in a safe state, but also sample the blood temperature by using the third temperature sensor to further judge whether the difference between the replacement fluid temperature and the blood temperature is too large, and issue an indication to the user based on the indication signal of a normal state whether the difference between the replacement fluid temperature and the blood temperature is too large. The embodiments of the present application improve the safety of blood purification treatment of the patient by using the first temperature sensor and the third temperature sensor.

[0167] Referring to Figure 3 Figure 3 In some embodiments, the blood purification apparatus further comprises a second temperature sensor 16, and the second temperature sensor 16 is arranged at the inlet of the heating cavity 6.

[0168] At this time, the method can further comprise the following steps:

[0169] Step S114: During the blood purification treatment stage, periodically sampling the temperature of the replacement fluid at the inlet of the heating cavity using the second temperature sensor to obtain a fifth sampling temperature.

[0170] Step S115: When the difference between the first sampling temperature after feedback adjustment and the fifth sampling temperature is less than or equal to a first preset safety value, issuing a second fault prompt information.

[0171] Specifically, the fifth sampling temperature represents the temperature of the replacement fluid before heating, and the actual difference between the first sampling temperature after feedback adjustment and the fifth sampling temperature represents the temperature variation amplitude of the replacement fluid caused by the heating process of the heating cavity. When the actual difference is less than or equal to the first preset safety value, it indicates that the heating efficiency of the heating cavity is too low, or the heating cavity itself is in an invalid heating state, and then a second fault prompt signal is issued to indicate to the user that the heating cavity is in a fault state. The user will immediately deal with the fault state of the heating cavity when noticing the second fault prompt signal, effectively eliminating the risk of heating cavity failure during the blood purification treatment stage.

[0172] It should be noted that the first preset safety value is a value set by the user in advance, for example, the first preset safety value is 1℃, and when the first sampling temperature - the fifth sampling temperature ≤ 1℃, the second fault prompt information of the heating cavity is issued.

[0173] It should be noted that the first preset safety value is a value set by the user in advance, for example, the first preset safety value is 1℃, and when the first sampling temperature - the fifth sampling temperature ≤ 1℃, the second fault prompt information of the heating cavity is issued.

[0174] It should be noted that the sequence numbers (such as S101, S102, …) of the above steps are only used to refer to the steps, and do not mean that the steps in the embodiments of the present application will be executed in the order of the sequence numbers. The steps in the embodiments of the present application will be executed according to the logical order of the technical solutions.

[0175] The application also provides a computer readable storage medium, which stores a computer program. When the computer program is executed by a processor, the processor implements the control method of the blood purification apparatus according to any one of the above. For details, please refer to the related content of the above method, which will not be repeated here.

[0176] The computer readable storage medium can be an internal storage unit of the blood purification apparatus, such as a hard disk or a memory. The computer readable storage medium can also be an external storage device, such as a plug-in hard disk, a smart memory card, a secure digital card, a flash memory card, etc.

[0177] It should be understood that the terms used in the present application are only for the purpose of describing specific embodiments and are not intended to limit the present application.

[0178] It should also be understood that the term "and / or" used in the present application specification and the appended claims means any combination of one or more of the associated listed terms and all possible combinations, and includes these combinations.

[0179] The above is only a specific embodiment of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art can easily think of various equivalent modifications or replacements within the technical scope disclosed by the present application, and these modifications or replacements should be covered within the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A blood purification apparatus characterized by comprising: The blood purification device comprises a blood circuit, a liquid supplement branch, a replacement fluid bag, a heating cavity, and a first temperature sensor; a first end of the liquid supplement branch is connected to the replacement fluid bag, a second end of the liquid supplement branch is connected to the blood circuit, the heating cavity is arranged on the liquid supplement branch, and the first temperature sensor is arranged at an outlet of the heating cavity; the blood purification device further comprises a memory and a processor; the memory is used to store a computer program; the processor is used to execute the computer program and, when the computer program is executed, implement the following control method of the blood purification device: During a blood purification treatment stage of the blood purification device, the blood circuit is connected to blood, the first temperature sensor is used to periodically sample the temperature of the replacement fluid at the outlet of the heating cavity to obtain a first sampling temperature; When the absolute value of the difference between the first sampling temperature and a preset standard temperature is greater than or equal to a first preset temperature and less than a second preset temperature, the heating power of the heating cavity is feedback adjusted according to the standard temperature and the first sampling temperature, and whether the liquid supplement branch is folded is determined according to the feedback-adjusted first sampling temperature; the first preset temperature and the second preset temperature are determined according to the standard temperature.

2. The blood purification device according to claim 1, characterized by, The processor is used to execute the computer program and, when the computer program is executed, implement the following control method of the blood purification device: The liquid supplement branch is pre-flushed, the heating cavity and the first temperature sensor are self-checked for faults during the pre-flushing stage, and it is determined whether the heating cavity and the first temperature sensor have faults; when it is determined that the heating cavity and the first temperature sensor do not have faults, the blood purification device is controlled to enter a blood purification treatment stage.

3. The blood purification device of claim 2, wherein, The blood purification device further comprises a peristaltic pump arranged on the liquid supplement branch between the heating cavity and the replacement fluid bag. The processor is used to execute the computer program and, when the computer program is executed, implement the following control method of the blood purification device: The peristaltic pump is controlled to operate, and the liquid supplement branch is controlled to output pre-flushing liquid to the blood circuit; An initial power is determined according to the standard temperature and a preset comparison relationship, and the heating cavity is controlled to heat the pre-flushing liquid in the liquid supplement branch according to the initial power; When the continuous operation time of the peristaltic pump is greater than a first preset time, the first temperature sensor is used to periodically sample the temperature of the pre-flushing liquid at the outlet of the heating cavity to obtain a second sampling temperature; When the duration for which the second sampling temperature is located within a preset constant temperature range is greater than or equal to a second preset time, a temperature difference between the standard temperature and the second sampling temperature is determined; When the temperature difference satisfies a first condition, the blood purification device is controlled to enter a blood purification treatment stage; the first condition is that the absolute value of the temperature difference is less than or equal to a third preset temperature. When the temperature difference meets a second condition, a modified heating power is determined according to the temperature difference, and the heating cavity is controlled to heat the priming liquid in the liquid supplement branch according to the modified heating power, the second condition being that an absolute value of the temperature difference is greater than the third preset temperature and less than or equal to a fourth preset temperature; When the temperature difference meets a third condition, it is determined that the heating cavity and / or the first temperature sensor has a fault, the third condition being that an absolute value of the temperature difference is greater than the fourth preset temperature.

4. The blood purification device of claim 3, wherein, The blood purification apparatus further comprises a second temperature sensor arranged at the inlet of the heating cavity; The processor is configured to execute the computer program and implement the following control method of the blood purification apparatus when executing the computer program: The second temperature sensor is used to periodically sample the temperature of the priming liquid at the inlet of the heating cavity to obtain a third sampling temperature; The specific heat capacity of the priming liquid, the density of the priming liquid, the flow rate of the priming liquid are obtained, and the initial power is determined according to a second formula, wherein the second formula is: Initial power = preset coefficient * density of priming liquid * specific heat capacity of priming liquid * flow rate of priming liquid * (standard temperature - third sampling temperature), wherein the preset coefficient is a preset value.

5. The blood purification device of claim 1, wherein, The processor is configured to execute the computer program and implement the following control method of the blood purification apparatus when executing the computer program: The specific heat capacity of the replacement liquid, the density of the replacement liquid, and the pre-set flow rate of the replacement liquid are obtained, and the feedback-adjusted heating power is determined according to a third formula, wherein the third formula is: feedback-adjusted heating power = preset coefficient * density of replacement liquid * specific heat capacity of replacement liquid * flow rate of replacement liquid * (standard temperature - first sampling temperature) + feedback-adjusted heating power before feedback adjustment; wherein the preset coefficient is a preset value; The heating cavity is controlled to heat the replacement liquid in the liquid supplement branch according to the feedback-adjusted heating power.

6. The blood purification device of claim 5, wherein, The processor is configured to execute the computer program and implement the following control method of the blood purification apparatus when executing the computer program: When the feedback-adjusted first sampling temperature meets a fourth condition, it is determined that the liquid supplement branch has a pipe folding; The fourth condition is that an absolute value of a temperature difference between the standard temperature and the feedback-adjusted first sampling temperature is greater than a sixth preset temperature; When the feedback-adjusted first sampling temperature meets a fifth condition, and a continuous time during which the feedback-adjusted first sampling temperature meets the fifth condition is greater than or equal to a third preset time, it is determined that the liquid supplement branch has a pipe folding; The fifth condition is that an absolute value of a temperature difference between the standard temperature and the feedback-adjusted first sampling temperature is greater than a fifth preset temperature and less than or equal to the sixth preset temperature, and the third preset time is n * sampling period of the first temperature sensor, wherein n is a positive integer greater than 0. When the first sampling temperature after feedback adjustment satisfies the fifth condition, and the continuous time when the first sampling temperature after feedback adjustment satisfies the fifth condition is less than the third preset time, it is determined that the liquid supplement branch does not have a pipe folding.

7. The blood purification device of claim 6, wherein, The blood purification apparatus further comprises a peristaltic pump arranged on the liquid supplement branch between the heating cavity and the replacement fluid bag; the liquid supplement branch comprises a first branch, a second branch and a third branch; the first branch is a pipeline between the replacement fluid bag and the peristaltic pump, the second branch is a pipeline between the peristaltic pump and the heating cavity, and the third branch is a pipeline between the heating cavity and the blood circuit; The processor is configured to execute the computer program and implement the following control method of the blood purification apparatus when executing the computer program: When it is determined that the liquid supplement branch has a pipe folding, it is detected whether the temperature of the replacement fluid in the liquid supplement branch fluctuates; when it is detected that the temperature of the replacement fluid in the liquid supplement branch does not fluctuate, it is determined that the third branch has a pipe folding; and when it is detected that the temperature of the replacement fluid in the liquid supplement branch fluctuates, it is determined that the first branch and / or the second branch has a pipe folding.

8. The blood purification device of claim 6, wherein, The processor is configured to execute the computer program and implement the following control method of the blood purification apparatus when executing the computer program: When the heating cavity is controlled to heat the replacement fluid in the liquid supplement branch according to the heating power after feedback adjustment, and the first sampling temperature after feedback adjustment satisfies the fourth condition, it is determined that the liquid supplement branch is completely blocked; When the continuous time when the first sampling temperature after feedback adjustment satisfies the fifth condition is greater than or equal to the third preset time, it is determined that the liquid supplement branch is partially blocked.

9. The blood purification device of claim 1, wherein, The processor is configured to execute the computer program and implement the following control method of the blood purification apparatus when executing the computer program: When the absolute value of the difference between the first sampling temperature and the standard temperature is less than a first preset temperature, the blood circuit is controlled to flow at a preset flow rate; When the absolute value of the difference between the first sampling temperature and the standard temperature is greater than or equal to a second preset temperature, it is determined that the heating cavity has a heating fault, and a first fault prompt signal is sent out; The blood purification apparatus further comprises a third temperature sensor arranged on the blood circuit. The processor is configured to execute the computer program and implement the following control method of the blood purification apparatus when executing the computer program: When the absolute value of the difference between the first sampling temperature and the standard temperature is less than the first preset temperature, the blood temperature in the blood circuit is periodically sampled by the third temperature sensor to obtain a fourth sampling temperature; When the absolute value of the temperature difference between the first sampling temperature and the fourth sampling temperature is less than a seventh preset temperature, the blood circuit is controlled to flow at the preset flow rate, and an indication signal of a normal state is sent out.

10. A computer-readable storage medium, characterized in that, The computer readable storage medium stores a computer program, and the computer program, when executed by a processor, causes the processor to implement the control method of the blood purification apparatus according to any one of claims 1-9.

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