A soothing serum comprising transparent microbeads and a method of making the same

Abstract

The application discloses a soothing serum containing transparent microbeads, and preparation raw materials include 80-85 parts of phase A, 3-5 parts of phase B, 0.5-1 part of phase C, 10-12 parts of phase D and 3-5 parts of phase E in terms of weight percentage; the phase A includes water, the phase B includes an alcohol solution, the phase C is a pigment solution, the phase D includes an oil phase rheological modifier, and the phase E includes plant extracts. By introducing an acrylate crosslinked copolymer and an oil phase rheological modifier, small oil bead can be uniformly dispersed in the serum system, the small oil bead can be uniformly dispersed in the water phase, has a burst bead skin feeling when used, and the active components are wrapped in the oil bead, the activity of the active components is maintained for a long time, and the effect is long-lasting. The active components are visualized, high color value and strong effect coexist, the active components are wrapped by the lipid oil bead, are more moisturizing and fresh-keeping, the active components are slowly released, the effect is more long-lasting, and the activity, color and size of the oil bead can be adjusted, and the application range is wide.

Description

Technical Field

[0001] This invention relates to a soothing serum containing transparent microbeads and its preparation method, and relates to A61K, specifically to the field of cosmetic products. Background Technology

[0002] Using oils for skincare has been a common practice throughout history. However, the plant and animal oils used in ancient times were purely naturally extracted, had a short shelf life, and were not suitable for long-distance transportation. Later, skincare oils were extracted from mineral oils, increasing their shelf life and reducing costs. However, mineral oils did not provide a pleasant user experience. With advancements in technology, mixing skincare oils with water-based products can overcome the shortcomings of pure oils. However, the stability of the oil-water mixture is not high, and separation is common. Therefore, improving the stability of skincare oils while maintaining their moisturizing properties and the absorbency of water-based serums is a problem that needs to be solved in this field.

[0003] Chinese invention patent CN202210753043.1 discloses a cosmetic composition with suspended oil droplets and its preparation method, containing 5-10 parts by weight of an oil phase and 90-95 parts by weight of an aqueous phase. Water is used as the main solvent in the aqueous phase, and the oil phase appears as suspended oil droplets. Specific aqueous and oil phase components are compounded to prepare a cosmetic composition with high transparency and good fluidity, achieving excellent moisturizing and skin-softening effects while reducing skin irritation, giving the product a refreshing, easily absorbed, and non-greasy feel. However, the proportion of the oil phase is relatively low, failing to achieve the effect of nourishing the skin with oil. Chinese invention patent CN201710115741.8 discloses a stock solution formula and process with suspended oil droplets. By directly changing the physical properties of the fluid, the density of the aqueous phase is increased, bringing the oil and aqueous phases to approximately the same density, allowing the oil phase to exist within the aqueous phase. However, the stability of the oil phase in the aqueous phase is poor; after one month of storage, only 70% of the oil phase remains suspended, indicating poor storage performance. Summary of the Invention

[0004] To improve the dispersion of high-percentage skincare oils in an aqueous phase, enhance storage stability, and simultaneously provide moisturizing and easily absorbed effects, the first aspect of this invention provides a soothing essence containing transparent microbeads. The raw materials for preparation, by weight, include: 80-85 parts of phase A, 3-5 parts of phase B, 0.5-1 parts of phase C, 10-12 parts of phase D, and 3-5 parts of phase E; wherein phase A comprises water, phase B comprises an alcohol solution, phase C is a pigment solution, phase D comprises an oil-phase rheology modifier, and phase E comprises plant extracts.

[0005] In a preferred embodiment, the raw materials for preparing phase A further include, by weight: 5-10 parts of polyol, 0.2-0.5 parts of thickener, 0.1-0.3 parts of chelating agent, 1-3 parts of betaine, and 1-3 parts of moisturizing composition.

[0006] In a preferred embodiment, the polyol is a combination of glycerol and propylene glycol, wherein the weight ratio of glycerol to propylene glycol is (5-10):1, and more preferably, the weight ratio of glycerol to propylene glycol is 8:1.

[0007] In a preferred embodiment, the thickener is selected from one or a combination of xanthan gum, gum arabic, seaweed gum, acrylate copolymer, guar gum, pectin, and carrageenan.

[0008] In a preferred embodiment, the acrylate copolymer is a crosslinked copolymer of acrylates and alkanoic acid acrylates, wherein the alkanoic acid acrylate contains C14-244-3 ... 10 -C 30 Alkyl alcohols.

[0009] In a preferred embodiment, the thickener is an acrylate / C 10-30 The combination of alkanol acrylate cross-linked copolymer and xanthan gum in a weight ratio of (0.4-0.7):1.

[0010] In a preferred embodiment, the chelating agent is disodium EDTA.

[0011] In a preferred embodiment, the moisturizing composition is a combination of dextran and an alcohol-based moisturizer, wherein the alcohol-based moisturizer is a combination of butylene glycol and hexanediol.

[0012] In a preferred embodiment, the moisturizing composition is a combination of water, butylene glycol, β-glucan, and 1,2-hexanediol.

[0013] In a preferred embodiment, the raw materials for preparing phase B include, by weight, 0.1-0.5 parts of p-hydroxyacetophenone, 0.5-1 parts of 1,2-hexanediol, and 2-5 parts of 1,3-butanediol.

[0014] In a preferred embodiment, the raw materials for preparing the soothing essence also include 0.1-1 parts of F phase, wherein the F phase is a pH adjustment phase.

[0015] In a preferred embodiment, the pH adjusting phase is selected from one of sodium hydroxide solution, potassium hydroxide solution, and triethanolamine solution, wherein the sodium hydroxide solution is an aqueous solution of sodium hydroxide with a mass fraction of 8-15%. Preferably, the sodium hydroxide solution is an aqueous solution of sodium hydroxide with a mass fraction of 10%.

[0016] In a preferred embodiment, the solvent of the pigment solution is propylene glycol or glycerol, and the mass concentration of the pigment solution is 1-3‰.

[0017] In a preferred embodiment, the pigment solution is a carmine propylene glycol solution and a sunset yellow propylene glycol solution in a weight ratio of 1:3.

[0018] In a preferred embodiment, the raw materials for preparing the D phase include, by weight, 0.03-0.05 parts of fragrance and 5-15 parts of oil phase rheology modifier.

[0019] In a preferred embodiment, the raw materials for preparing the D phase include 0.04 parts of fragrance and 10 parts of oil phase rheology modifier by weight.

[0020] In a preferred embodiment, the oil phase rheology modifier comprises squalane, castor oil / IPDI copolymer, caprylic / capric triglyceride, and triheptyl alcohol, in a weight ratio of (3-5):(2-5):(1-3):1.

[0021] In a preferred embodiment, the squalane, castor oil / IPDI copolymer, caprylic / capric triglyceride, and triheptyl alcohol are present in a weight ratio of 4:3:2:1.

[0022] During the experiment, the applicant discovered that introducing acrylate crosslinking copolymers into the aqueous phase and oil-phase rheology modifiers into the oil phase could create uniformly dispersed small oil droplets in the serum system. These droplets could be uniformly dispersed in the aqueous phase, providing a bursting sensation on the skin upon application. Furthermore, the active ingredients were encapsulated within these droplets, resulting in longer-lasting activity and sustained effects. The likely reason for this is the use of acrylates / C... 10-30 The alkanol acrylate crosslinking copolymer and the oil phase rheology modifier used in the oil phase can widen the surface tension difference between the aqueous and oil phases, thereby dispersing small oil droplets in the aqueous phase without dissolving them. Furthermore, by introducing alcohol components into the aqueous phase, the density of the small oil droplets and the continuous phase is made closer, thus ensuring uniform dispersion of the small oil droplets in the aqueous phase without stratification. The applicant's addition of xanthan gum to the aqueous phase increases the viscosity of the aqueous phase, increasing the resistance to the polymerization and buoyancy of the small oil droplets, further ensuring uniform dispersion and maintaining long-term storage stability even under thermal cycling conditions.

[0023] In a preferred embodiment, the raw materials for preparing the E phase also include a binder, which comprises butanediol, water, acrylic acid, and a copolymer salt of maleic anhydride.

[0024] In a preferred embodiment, the binder in the E phase is 1-5 parts by weight, and the plant extract is 1-3 parts by weight.

[0025] In a preferred embodiment, the plant extract comprises water, butylene glycol, 1,2-hexanediol, and peony root extract.

[0026] A second aspect of the present invention provides a method for preparing a soothing serum containing transparent microbeads, comprising the following steps:

[0027] (1) Accurately weigh all the ingredients in the formula and store them in sterilized clean containers;

[0028] (2) Heat phase B to 60°C until it dissolves and becomes transparent for later use;

[0029] (3) Add phase A to the water pot and stir at 20-50 r / min to heat to 80-90℃; stir at 20-50 r / min to dissolve for 0.5-1 h, then homogenize for 5-10 min to ensure all raw materials are dissolved, and keep the temperature at 85-90℃ while stirring at 20-50 r / min to defoam; after defoaming, turn on the cooling water and stir at 10-30 r / min to cool down;

[0030] (4) Cool down to 60-70℃, add phase B, phase C, and dissolve the transparent phase D. Stir for 10-30 r / min to adjust the size of the oil droplets.

[0031] (5) Stir and cool to 30-40℃, add phase E and phase F, and stir until homogeneous;

[0032] (6) Cool down to below 30°C and filter the material through a 10-mesh filter.

[0033] In step 2 of the preparation process of this invention, phase B is heated to 60°C and phase D is heated to 90°C. Only at the preferred temperature can the transparency of the microspheres be maintained. Below the preferred temperature, the solubility is poor, which will cause the microspheres to be opaque. Above the preferred temperature, the components are prone to oxidation and produce an odor.

[0034] Compared with the prior art, the present invention has the following beneficial effects:

[0035] (1) The soothing essence containing transparent microbeads of the present invention can form uniformly dispersed small oil beads in the essence system by introducing acrylate cross-linked copolymer in the aqueous phase and oil phase rheology modifier in the oil phase. The small oil beads can be uniformly dispersed in the aqueous phase, and have a bursting skin feel when used. The effective components are encapsulated in the oil beads, and the activity of the effective components is maintained for a longer time, resulting in a long-lasting effect.

[0036] (2) The soothing essence containing transparent microbeads described in this invention, through the use of acrylates / C in the aqueous phase... 10-30The combination of alkanol acrylate cross-linked copolymer and xanthan gum increases the resistance to the polymerization and floating of small oil droplets, thereby further dispersing the small oil droplets evenly and maintaining long-term storage stability in hot and cold cycling environments.

[0037] (3) The soothing essence containing transparent microbeads described in this invention has visible active ingredients, high appearance and strong efficacy. The lipid oil beads encapsulate the active ingredients, making them more moisturizing and fresher. The active ingredients are released slowly, resulting in a longer-lasting effect. Furthermore, the active ingredients, color and size of the oil beads can be adjusted, making it suitable for a wide range of applications. Attached Figure Description

[0038] Figure 1 The soothing essence prepared in Example 1;

[0039] Figure 2 The soothing essence prepared in Example 2;

[0040] Figure 3 The soothing essence prepared in Example 3;

[0041] Figure 4 The soothing essence prepared in Example 4. Detailed Implementation

[0042] Example 1

[0043] A soothing essence containing transparent microbeads, the raw materials for preparation include, by weight: 80.56 parts of phase A, 4.1 parts of phase B, 0.8 parts of phase C, 10.04 parts of phase D, 4 parts of phase E, and 0.5 parts of phase F. Phase A includes water, phase B includes an alcohol solution, phase C is a pigment solution, phase D includes an oil-based rheology modifier, and phase E includes plant extracts.

[0044] The raw materials for preparing phase A include, by weight: 9 parts polyol, 0.3 parts thickener, 0.1 parts chelating agent, 2 parts betaine, 2 parts moisturizing composition, and 67.16 parts water.

[0045] The polyol is a combination of glycerol and propylene glycol in a weight ratio of 8:1.

[0046] The thickener is an acrylate / C 10 -C 30 The combination of alkyl acrylate crosslinked copolymer and xanthan gum, in a weight ratio of 0.5:1. The acrylate / C 10 -C 30 The alkanol acrylate crosslinked copolymer was purchased from Lubrizol Specialty Chemicals Manufacturing (Shanghai) Co., Ltd.

[0047] The chelating agent is disodium EDTA.

[0048] The moisturizing composition is a combination of water, butylene glycol, β-glucan and 1,2-hexanediol, purchased from Naibo Guangzhou Panhai Fine Chemical Co., Ltd.

[0049] The raw materials for preparing phase B include, by weight, 0.3 parts of p-hydroxyacetophenone, 0.8 parts of 1,2-hexanediol, and 3 parts of 1,3-butanediol.

[0050] The pigment solution is a carmine propylene glycol solution and a sunset yellow propylene glycol solution in a weight ratio of 1:3. The mass concentration of the carmine propylene glycol solution is 1‰ and the mass concentration of the sunset yellow propylene glycol solution is 1‰.

[0051] The raw materials for preparing the D phase include 0.04 parts of fragrance and 10 parts of oil phase rheology modifier by weight. The oil phase rheology modifier includes squalane, castor oil / IPDI copolymer, caprylic / capric triglyceride, and triheptyl alcohol, in a weight ratio of 4:3:2:1, and was purchased from Guangzhou Panhai Fine Chemical Co., Ltd.

[0052] The raw materials for preparing phase E include, by weight, 3 parts of binder and 1 part of plant extract; the plant extract comprises water, butylene glycol, 1,2-hexanediol, and peony root extract, purchased from Naibo Guangzhou Panhai Fine Chemical Co., Ltd.; the binder comprises butylene glycol, water, acrylic acid, and maleic anhydride copolymer sodium, purchased from Naibo Guangzhou Panhai Fine Chemical Co., Ltd.

[0053] The F phase is a 10% sodium hydroxide aqueous solution by mass.

[0054] A method for preparing a soothing serum containing transparent microbeads includes the following steps:

[0055] (1) Accurately weigh all the ingredients in the formula and store them in sterilized clean containers;

[0056] (2) Heat phase B to 60°C to dissolve and make it transparent for later use; heat phase D to 90°C to dissolve and make it for later use.

[0057] (3) Add phase A to the water pot and stir at 30 r / min to heat to 85℃; stir at 30 r / min to dissolve for 0.5 h, then homogenize for 5 min to ensure that all raw materials are dissolved well, and keep the temperature at 85℃ and stir at 20 r / min to defoam; after defoaming, turn on the cooling water and stir at 20 r / min to cool down;

[0058] (4) Cool down to 65℃ and add phase B, phase C and phase D at 90℃, and start stirring at 60r / min to adjust the size of the oil droplets;

[0059] (5) Stir and cool to 35℃, add phase E and phase F, and stir until homogeneous;

[0060] (6) Cool down to below 30°C and filter the material through a 10-mesh filter.

[0061] Example 2

[0062] A soothing serum containing transparent microbeads and its preparation method are described. The specific preparation steps are the same as in Example 1, except that the thickener is an acrylate / C 10-30 A crosslinked copolymer of alkyl acrylates, xanthan gum, and carbomer, in a weight ratio of 0.5:0.2:20. Phase C: 0.4 parts, wherein the pigment solution in Phase C is a carmine propylene glycol solution and a sunset yellow propylene glycol solution in a weight ratio of 1:1, with the carmine propylene glycol solution having a mass concentration of 1‰ and the sunset yellow propylene glycol solution having a mass concentration of 1‰. Phase F: 0.9 parts. The acrylate / C... 10 -C 30 The alkanol acrylate crosslinked copolymer was purchased from Lubrizol Specialty Chemicals Manufacturing (Shanghai) Co., Ltd.

[0063] Example 3

[0064] A soothing essence containing transparent microbeads and its preparation method are disclosed. The specific preparation steps are the same as in Example 1, except that the raw materials for the D phase preparation include 0.04 parts by weight of fragrance and 8 parts by weight of oil phase rheology modifier. The pigment solution is oil-soluble blue and oil-soluble blue in a weight ratio of 0.03:0.1, with the oil-soluble blue having a mass concentration of 1‰.

[0065] Example 4

[0066] A soothing essence containing transparent microbeads and its preparation method are disclosed. The specific preparation steps are the same as in Example 1, except that the raw materials for the D phase preparation include 0.04 parts by weight of fragrance and 20 parts by weight of oil phase rheology modifier. The pigment solution is a carmine propylene glycol solution and a sunset yellow propylene glycol solution in a weight ratio of 1:1. The mass concentration of the carmine propylene glycol solution is 1‰, and the mass concentration of the sunset yellow propylene glycol solution is 1‰.

[0067] Example 5

[0068] A soothing essence containing transparent microbeads and its preparation method are disclosed. The specific preparation steps are the same as in Example 1, except that the temperature of phase D in step 2 is 80°C.

[0069] Example 6

[0070] A soothing essence containing transparent microbeads and its preparation method are disclosed. The specific preparation steps are the same as in Example 1, except that the temperature of phase D in step 2 is 95°C.

[0071] Performance testing

[0072] 1. Appearance: Visually inspect the appearance of the products prepared in Examples 1-4;

[0073] 2. pH: The pH value was measured using a pH meter;

[0074] 3. Viscosity: The viscosity of Examples 1-6 was tested using a viscometer.

[0075] 4. Centrifugation stability: Centrifuge the products prepared in Examples 1-3 at 3000 r / min for 30 minutes and observe whether stratification occurs.

[0076] 5. High and low temperature cycling performance: The products prepared in Examples 1-3 were cycled in an environment of 2℃ to 45℃ for 30 days to test their high and low temperature cycling performance.

[0077] The test results are shown in Table 1.

[0078] Table 1

[0079]

[0080]

[0081] 6. Soothing Test: The soothing effect of the soothing essence prepared in Example 1 was tested. Thirty volunteers were selected and used the soothing essence of Example 1 continuously for 28 days. The skin color (red-green) value a* value was measured using an instrument probe, and a lactic acid stinging test was performed. The smaller the a* value, the less red the skin color.

[0082] 6.1 Lactic acid stinging test:

[0083] The application method was used for testing. 10% lactic acid was applied to the nasolabial folds and one cheek at room temperature. The sensitivity response of the subjects was rated on a 4-point scale at 0.5, 2.5, and 5 minutes. The three scores were then added together. The lower the score, the lower the degree of lactic acid stimulation.

[0084] Testing time points: before using the sample and 28 days after using the sample.

[0085] The test results are shown in Table 2.

[0086] Table 2

[0087]

[0088] 6.2 Analysis of differences in skin color a* values:

[0089] Before using the sample

[0090] Two days prior to the test, participants discontinued the use of cosmetics or topical medications. On the evening of the test, participants washed their face at home and did not apply any skincare products. On the morning of the test, participants washed their face with water at home and did not apply any skincare products.

[0091] Lactic acid stinging test is used to screen subjects with sensitive skin; those with a score >4 are included.

[0092] Qualified participants completed the informed consent form.

[0093] Subjects were included in the laboratory who used laboratory-provided facial cleansing products to clean their faces.

[0094] Subjects rested for 30 minutes in an environment with a temperature of 21±1℃ and a relative humidity of 50±10%RH.

[0095] A dermatologist conducts a clinical evaluation:

[0096] The experimenter used the KONICA MINOLTA CM-700d spectrophotometer to detect skin color:

[0097] The lab technician distributed test samples and instructions for use.

[0098] 14 days after using the sample

[0099] Subjects cleansed their faces in the laboratory using laboratory-provided facial cleansing products:

[0100] Subjects rested for 30 minutes in an environment with a temperature of 21±1℃ and a relative humidity of 50±10%RH.

[0101] The experimenter used the KONICA MINOLTA CM-700d spectrophotometer to detect skin color:

[0102] Subject self-assessment.

[0103] 28 days after using the sample

[0104] Subjects cleansed their faces in the laboratory using laboratory-provided facial cleansing products:

[0105] Subjects rested for 30 minutes in an environment with a temperature of 21±1℃ and a relative humidity of 50±10%RH.

[0106] The experimenter used the KONICA MINOLTA CM-700d spectrophotometer to detect skin color:

[0107] Lactic acid stinging test:

[0108] Subject self-assessment:

[0109] Laboratory recovery of test samples.

[0110] Change rate = (After using sample - Before using sample) / Before using sample × 100%

[0111] The test results are shown in Table 3.

[0112] Table 3

[0113] Before using the sample After 14 days of use After 28 days of use 13.24 13.04 12.39 Change rate / % / -1.51 -6.42

[0114] 7. Skin Moisture and Oil Content Test: To test the nourishing effect of the soothing essence prepared in Example 1, 30 volunteers were selected and used the soothing essence of Example 1 continuously for 28 days. The moisture content of the stratum corneum and the oil content of the skin were measured using an instrument probe to evaluate the nourishing efficacy.

[0115]

[0116] Before using the sample

[0117] Two days before the test begins, participants should discontinue the use of cosmetics or topical medications.

[0118] The night before the test, the participants washed their faces at home and did not apply any skincare products.

[0119] On the morning of the test, the participants did not apply any skincare products at home:

[0120] Qualified participants completed the informed consent form.

[0121] Subjects rested for 30 minutes in an environment with a temperature of 21±1℃ and a relative humidity of 50±10%RH.

[0122] The experimenter used a skin oil testing probe SM815 was used to detect skin oil content; skin oil content ≤90μg / cm³ 2 Those included:

[0123] Subjects were included in the laboratory who used laboratory-provided facial cleansing products to clean their faces.

[0124] Subjects rested for 30 minutes in an environment with a temperature of 21±1℃ and a relative humidity of 50±10%RH.

[0125] The experimenter used a skin moisture meter CM825 tests the moisture content of the skin's stratum corneum:

[0126] The lab technician distributed test samples and instructions for use.

[0127] 14 days after using the sample

[0128] On the morning of the test, I washed my face with water at home and did not apply any skincare products.

[0129] Subjects rested for 30 minutes in an environment with a temperature of 21±1℃ and a relative humidity of 50±10%RH.

[0130] The experimenter used a skin oil testing probe SM815 tests skin oil content:

[0131] Subjects cleansed their faces in the laboratory using laboratory-provided facial cleansing products:

[0132] Subjects rested for 30 minutes in an environment with a temperature of 21±1℃ and a relative humidity of 50±10%RH.

[0133] The experimenter used a skin moisture meter CM825 tests the moisture content of the skin's stratum corneum:

[0134] Subject self-assessment.

[0135] 28 days after using the sample

[0136] On the morning of the test, I washed my face with water at home and did not apply any skincare products.

[0137] Subjects rested for 30 minutes in an environment with a temperature of 21±1℃ and a relative humidity of 50±10%RH.

[0138] The experimenter used a skin oil testing probe SM815 tests skin oil content:

[0139] Subjects cleansed their faces in the laboratory using laboratory-provided facial cleansing products:

[0140] Subjects rested for 30 minutes in an environment with a temperature of 21±1℃ and a relative humidity of 50±10%RH.

[0141] The experimenter used a skin moisture meter CM825 tests the moisture content of the skin's stratum corneum:

[0142] The lab technician retrieved the test samples:

[0143] Subject self-assessment.

[0144] Change rate = (After using sample - Before using sample) / Before using sample × 100%

[0145] The results of the moisture content test are shown in Table 4, and the results of the oil content test are shown in Table 5.

[0146] Table 4

[0147]

[0148]

[0149] Table 5

[0150] Before using the sample After 14 days of use After 28 days of use 51 67 70 Change rate / % / 31.37 37.25

[0151] After using the product, the moisture content of the stratum corneum and the oil content of the skin were significantly improved, indicating that this product has a good moisturizing effect.

Claims

1. A soothing serum containing transparent microbeads, characterized in that, The raw materials for preparation include, by weight: 80-85 parts of phase A, 3-5 parts of phase B, 0.5-1 parts of phase C, 10-12 parts of phase D, 3-5 parts of phase E, and 0.1-1 parts of phase F; wherein phase A includes water, phase B includes an alcohol solution, phase C is a pigment solution, phase D includes an oil-based rheology modifier, phase E includes plant extracts, and phase F is a pH adjusting phase; The raw materials for preparing phase A also include, by weight: 5-10 parts of polyol, 0.2-0.5 parts of thickener, 0.1-0.3 parts of chelating agent, 1-3 parts of betaine, and 1-3 parts of moisturizing composition; The oil phase rheology modifier includes squalane, castor oil / IPDI copolymer, caprylic / capric triglyceride, and triheptane, in a weight ratio of (3-5):(2-5):(1-3):1; The thickener includes an acrylate copolymer; The acrylate copolymer is a crosslinked copolymer of acrylates and alkanoyl acrylates, wherein the alkanoyl acrylate contains C10 acrylates. 10 -C 30 Alkyl alcohols; The method for preparing the soothing serum containing transparent microbeads includes the following steps: (1) Accurately weigh all the ingredients in the formula and place them in sterilized clean containers; (2) Heat phase B to 60℃ to dissolve and make it transparent for later use; heat phase D to 88-92℃ to dissolve and make it for later use. (3) Add phase A to the water pot and stir at 20-50 r / min to heat to 80-85℃; dissolve for 0.5-1 h, then homogenize for 5-10 min to ensure all raw materials are dissolved, keep the temperature at 80-85℃, stir at 20-30 r / min, and defoam for 20-30 min; after defoaming, turn on the cooling water and stir at 10-30 r / min to cool down; (4) Cool down to 60-70℃ and add phase B, phase C and phase D at 88-92℃, and start stirring at 50-70r / min to adjust the size of the oil droplets; (5) Stir and cool to 30-40℃, add phase E and phase F, and stir until homogeneous; (6) Cool down to below 30°C and filter the material through a 10-mesh filter.

2. The soothing essence containing transparent microbeads according to claim 1, characterized in that, The thickener also includes one or a combination of xanthan gum, gum arabic, seaweed gum, guar gum, pectin, and carrageenan.

3. The soothing essence containing transparent microbeads according to claim 1, characterized in that, The moisturizing composition is a combination of dextran and alcohol moisturizers, wherein the alcohol moisturizers are a combination of butylene glycol and hexanediol.

4. The soothing essence containing transparent microbeads according to claim 1, characterized in that, The pH adjusting phase is selected from one of sodium hydroxide solution, potassium hydroxide solution, and triethanolamine solution, wherein the sodium hydroxide solution is an aqueous sodium hydroxide solution with a mass fraction of 8-15%.

5. The soothing essence containing transparent microbeads according to claim 1, characterized in that, The solvent of the pigment solution is propylene glycol or glycerol, and the mass concentration of the pigment solution is 1-3‰.

6. The soothing essence containing transparent microbeads according to claim 1, characterized in that, The raw materials for preparing the E phase also include a binder, which comprises butanediol, water, acrylic acid, and a copolymer salt of maleic anhydride.

7. A method for preparing a soothing serum containing transparent microbeads according to any one of claims 1-6, comprising the following steps: (1) Accurately weigh all the ingredients in the formula and place them in sterilized clean containers; (2) Heat phase B to 60℃ to dissolve and make it transparent for later use; heat phase D to 88-92℃ to dissolve and make it for later use. (3) Add phase A to the water pot and stir at 20-50 r / min to heat to 80-85℃; dissolve for 0.5-1 h, then homogenize for 5-10 min to ensure all raw materials are dissolved, keep the temperature at 80-85℃, stir at 20-30 r / min, and defoam for 20-30 min; after defoaming, turn on the cooling water and stir at 10-30 r / min to cool down; (4) Cool down to 60-70℃ and add phase B, phase C and phase D at 88-92℃, and start stirring at 50-70r / min to adjust the size of the oil droplets; (5) Stir and cool to 30-40℃, add phase E and phase F, and stir until homogeneous; (6) Cool down to below 30°C and filter the material through a 10-mesh filter.

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