A thrombelastograph based on magnetic induction

Abstract

The application relates to the technical field of blood coagulation detection, in particular to a thromboelastograph based on magnetic induction. The application discloses a thromboelastograph based on magnetic induction, which comprises a blood storage device, a squeezing device and a measuring device. The application is based on cooperation of a magnetic sensor and a permanent magnet containing a coil, reciprocating squeezing of the blood to be measured is carried out through the squeezing device, the blood to be measured acts on the magnetic sensor, an induced current is generated in the coil and the size of thromboelasticity is reflected in real time, so that the whole process of blood coagulation and fibrinolysis is reflected. The application has the advantages of simple structure, convenient processing, reusable parts, and avoidance of unnecessary waste. The application utilizes the induced current generated by the magnetic sensor and the permanent magnet containing the coil, is active sensing, has small energy consumption, has low manufacturing difficulty and low cost. The application solves the problems of complex structure and large energy consumption of the existing thromboelastograph.

Description

Technical Field

[0001] This invention relates to the field of coagulation detection technology, and more specifically, to a thromboelastography instrument based on magnetic induction. Background Technology

[0002] Thromboelastography is an effective measurement instrument for assessing coagulation mechanisms in clinical patients.

[0003] Traditional thromboelastography (TEG) systems are generally based on capacitive sensors, optical sensors, and magnetic bead sensors. However, TEG systems based on these principles are complex in construction, expensive, and not easily adopted in small and medium-sized hospitals. In addition, these sensors consume a lot of energy. Summary of the Invention

[0004] Therefore, it is necessary to provide a thromboelastography instrument based on magnetic induction to address the problems of complex structure and high energy consumption of existing thromboelastography instruments.

[0005] This invention is achieved using the following technical solution:

[0006] This invention discloses a thromboelastography instrument based on magnetic induction, comprising: a blood storage device, a squeezing device, and a measuring device.

[0007] The blood storage device includes a base, a housing, and a connecting assembly. The connecting assembly detachably connects the housing to the base. A permanent magnet containing a coil is housed inside the base. The housing includes a cup and a magnetic sensor; one end of the cup has an opening for adding blood to be tested; the other end of the cup has a magnetic sensor that senses the pressure from the blood and, in conjunction with the permanent magnet, induces a current in the coil. A squeezing device extends into the cup through the opening. The squeezing device reciprocates by squeezing the blood, which then acts on the magnetic sensor. A measuring device is connected to the magnetic sensor to acquire the generated induced current and process it into a thromboelastography map.

[0008] As a further embodiment of the present invention, the base includes: a base and a positioning plate. A first groove is provided on the side of the base facing the housing. The positioning plate is provided on the side of the base facing the housing. A second groove is provided on the side of the positioning plate facing the base. The base and the positioning plate are integrated, so that the first groove and the second groove form a cavity for accommodating the permanent magnet.

[0009] As a further embodiment of the present invention, the positioning plate and the base are provided with corresponding positioning holes and are connected as one unit by locking screws.

[0010] As a further embodiment of the present invention, the connecting assembly includes a male buckle and a female buckle. The male buckle is located at the other end of the cup body and supports the magnetic sensor from its outer edge. The female buckle is located on the side of the positioning piece facing the housing. The female buckle has a connecting hole, into which the male buckle snaps and is detachably connected to the female buckle.

[0011] As a further aspect of the present invention, the male buckle is provided with a slot on its side, and the connecting hole is provided with a retractable locking block. The female buckle is provided with a spring switch to control the extension and retraction of the locking block, and thus cooperate with the slot to realize the detachable connection between the male and female buckles.

[0012] As a further aspect of the invention, a mounting groove is provided on the side of the buckle facing the housing for placing the magnetic sensor. The other end of the cup body presses the magnetic sensor into the mounting groove via a washer; a through hole is provided in the center of the mounting groove to provide space for the deformation of the magnetic sensor.

[0013] As a further embodiment of the present invention, a second through hole is provided on the side of the positioning piece facing the housing, and the second through hole communicates with the second groove.

[0014] As a further aspect of the present invention, the distance between the magnetic sensor and the base is 5-8 mm.

[0015] As a further embodiment of the present invention, one end of the extrusion device extending into the cup body is convex spherical, and the gap between its maximum diameter and the inner wall of the cup body is 1 to 1.5 mm.

[0016] As a further aspect of the present invention, the blood storage device is also provided with a temperature control device, which is used to maintain the temperature of the blood storage device stable.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] 1. This invention is based on the combination of a magnetic sensor and a permanent magnet containing a coil. The blood to be tested is reciprocated by a squeezing device, and the blood to be tested acts on the magnetic sensor, generating an induced current in the coil and reflecting the magnitude of the thrombus elasticity in real time, thereby reflecting the entire process of blood coagulation and fibrinolysis.

[0019] 2. The present invention has a simple structure and is easy to process. By cooperating with a magnetic sensor and a permanent magnet containing a coil, the magnitude of thromboelastography is converted into the magnitude of induced current amplitude in real time, thereby simplifying circuit processing and reducing the manufacturing cost of the entire thromboelastography instrument. Furthermore, some components of the present invention can be reused, avoiding unnecessary waste.

[0020] 3. This invention utilizes a magnetic sensor to generate an induced current with a permanent magnet containing a coil, which is an active sensing method with low energy consumption; moreover, the magnetic sensor is easy to manufacture and has low cost. Attached Figure Description

[0021] Figure 1 This is a structural diagram of the thromboelastography instrument based on magnetic induction in this invention;

[0022] Figure 2 for Figure 1 Exploded view;

[0023] Figure 3 for Figure 1 Structural diagram after removing the extrusion device;

[0024] Figure 4 for Figure 3 Side view of the middle shell separated from the base;

[0025] Figure 5 for Figure 3 Exploded view;

[0026] Figure 6 for Figure 1 A cross-sectional view of the cup opening when the limiting plate of the middle extrusion device is stuck in the cup body opening;

[0027] Figure 7 for Figure 1 The process of coagulation testing using a thromboelastography instrument.

[0028] The attached diagram lists the components represented by each number as follows:

[0029] 10. Extrusion device; 20. Housing; 21. Cup body; 22. Washer; 23. Magnetic sensor; 24. Female buckle; 30. Base; 31. Female buckle; 311. Spring switch; 32. Positioning piece; 33. Permanent magnet; 34. Base. Detailed Implementation

[0030] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0031] It should be noted that when a component is said to be "installed on" another component, it can be directly on the other component or it may be in a component that is centered on it. When a component is said to be "set on" another component, it can be directly set on the other component or it may also be in a component that is centered on it. When a component is said to be "fixed to" another component, it can be directly fixed to the other component or it may also be in a component that is centered on it.

[0032] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein in the specification of this invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "or / and" as used herein includes any and all combinations of one or more of the associated listed items.

[0033] Example 1

[0034] Please see Figure 1 , Figure 1 This is a structural diagram of a thromboelastography instrument based on magnetic induction. See also... Figure 2 ,for Figure 1 Exploded view. The thromboelastography instrument based on magnetic induction includes: a blood storage device, a compression device 10, and a measuring device (not shown).

[0035] The blood storage device is the core of this invention. See also... Figure 3 , Figure 4 , Figure 5 The blood storage device includes a base 30, a housing 20, and a connecting component.

[0036] First, consider the base 30. The base 30 contains a permanent magnet 33 with a coil. Generally, the base 30 is designed as a hollow structure with an internal cavity for storing the permanent magnet 33. In this embodiment 1, for ease of assembly, the base 30 is processed into two parts: a base 34 and a positioning plate 32. The side of the base 34 facing the housing 20 has a groove. The positioning plate 32 is located on the side of the base 34 facing the housing 20. The side of the positioning plate 32 facing the base 34 has a second groove. Positioning holes are machined on the positioning plate 32 and the base 34, and they are connected as one unit by locking screws. Thus, the base 34 and the positioning plate 32 fit together as one unit, with grooves one and two forming a cavity for accommodating the permanent magnet 33. The permanent magnet 33 can be made of AlNiCo, permanent magnet ferrite, SmCo5, or Sm2Co. 17 ), sintered Nd2Fe 14 B) Bonded NdFeB (Nd2Fe) 14 B) One of the following: rubber magnets. The thickness of the permanent magnet 33 is 3-5 mm, or may be appropriately increased or decreased depending on the actual situation. Several coils (not shown) are provided on one side or inside the permanent magnet 33 to generate induced current. See also Figure 5 The coil can be installed in the groove and held in place by the permanent magnet 33. The coil can be wound in a manner similar to that of a magnetic levitation coil.

[0037] Next, let's look at the housing 20. The housing 20 includes a cup body 21 and a magnetic sensor 23. One end of the cup body 21 has an opening for adding the blood to be tested into the cup body 21. The other end of the cup body 21 has a magnetic sensor 23, which is used to sense the pressure from the blood to be tested and cooperates with the permanent magnet 33 to generate an induced current in the coil.

[0038] The cup body 21 is recommended to be made of a rigid material that is blood-reactive—it will neither promote nor hinder blood clotting.

[0039] The other end of the cup body 21 also has an opening, but it is sealed by the magnetic sensor 23. The magnetic sensor 23 is a flexible magnetic thin-film sensor, made of a blood-reactive material, with a thickness of 100-300 μm. Specifically, the magnetic sensor 23 is made of a flexible and magnetic thin-film material, obtained by adding magnetic materials to the thin-film sensor material. The thin-film sensor material can be one of silicone, polydimethylsiloxane, or thermoplastic polyurethane elastomer. The magnetic material can be an alloy permanent magnet material, such as rare earth permanent magnet material (neodymium iron boron Nd2Fe). 14 B) Samarium cobalt (SmCo, SmCo5 and Sm2Co) 17 It can be one of the following: AlNiCo powder, or one of silicon steel, permalloy, iron-based, iron-nickel-based, cobalt-based amorphous alloys, and iron-based nanocrystalline alloys.

[0040] Continuing with the connecting assembly, this assembly detachably connects the housing 20 to the base 30. This allows the base 30 to serve as a long-term fixture. The housing 20 can be chosen as a single-use device depending on its intended use: if single-use, simply remove the used housing 20 and replace it with a new one after each use; if you wish to reuse the housing 20, remove the used housing 20, clean it using ultrasonic or rapid rinsing, allow it to dry, and then reinstall it.

[0041] In this embodiment 1, the connecting assembly adopts a snap-fit ​​design, including a male snap 24 and a female snap 31. The male snap 24 is fixed to the other end of the cup body 21 and supports the magnetic sensor 23 from its outer edge. The side of the male snap 24 facing the housing 20 has a mounting groove for placing the magnetic sensor 23. The other end of the cup body 21 is pressed into the mounting groove by a washer 22. (See reference...) Figure 3A clip is machined at the other end of the cup body 21. The clip engages with the mounting groove and presses down on the magnetic sensor 23 via the washer 22. This achieves both the fixation of the magnetic sensor 23 and the sealing of the other end of the cup body 21. Furthermore, a through hole is machined in the center of the mounting groove to provide space for the magnetic sensor 23 to deform; that is, the magnetic sensor 23 can deform through the through hole under the pressure of incoming blood. A female buckle 31 is fixed to the side of the positioning piece 32 facing the housing 20. The female buckle 31 has a connecting hole, into which a male buckle 24 engages and is detachably connected to the female buckle 31.

[0042] In addition, the side of the positioning piece 32 facing the housing 20 is machined with a through hole 2, which is connected to the groove 2, thus providing more space for the magnetic sensor 23 to deform.

[0043] In general, there is a certain gap between the magnetic sensor 23 and the base 30, with the distance controlled at 5-8mm, to ensure that the deformation of the magnetic sensor 23 is not hindered.

[0044] To improve the reliability of the connection between the male and female buckles 31, a slot can be machined on the side of the female buckle 24, and a retractable locking block is provided on the inner ring of the connection hole. A spring-loaded switch 311 is provided on the female buckle 31 to control the extension and retraction of the locking block, which then engages with the slot to achieve a detachable connection between the female buckle 24 and the female buckle 31. Specifically, pressing the spring-loaded switch 311 causes the locking block to retract into the inner ring of the connection hole, disengaging the female buckle 24 and the female buckle 31; releasing the spring-loaded switch 311 causes the locking block to automatically pop out, engaging the slot and locking the female buckle 24 within the connection hole.

[0045] For the squeezing device 10: The squeezing device 10 extends into the cup body 21 from the opening of the cup body 21. The squeezing device 10 is used to reciprocate to squeeze the blood to be tested, and the blood to be tested acts on the magnetic sensor 23.

[0046] The squeezing device 10 can be controlled by an adjustable telescopic device, such as an electric push rod or an electric telescopic rod, which can be set to a constant pressure and a constant squeezing distance, and then repeatedly squeeze the blood in the cup up and down. It should be noted that the squeezing depth of the squeezing device 10 must not exceed a threshold value to avoid excessive squeezing that could damage the magnetic sensor 23 or cause blood to overflow from the cup 21. Of course, see [link to other documentation] Figure 6 Alternatively, a limiting plate can be provided on the extrusion device 10. When the extrusion device 10 extends downward into the cup body 21, the limiting plate can lock the opening of the cup body 21 to restrict it and prevent the extrusion device 10 from moving downward excessively.

[0047] The end of the squeezing device 10 that extends into the cup body 21 is convex spherical, with a gap of 1–1.5 mm between its maximum diameter and the inner wall of the cup body 21. It should be noted that the material used for the end of the squeezing device 10 that extends into the cup body 21 is also blood-reactive—it neither promotes nor hinders blood clotting. When the convex spherical end squeezes the blood, if the blood is liquid, it can easily rise through this gap; however, if the blood is solid, it becomes more difficult to rise through this gap.

[0048] Therefore, by using the squeezing device 10 to act on the blood, the process of the blood changing from a liquid state to a solid state and then back to a liquid state will in turn affect the change in distance between the magnetic sensor 23 and the permanent magnet 33. The magnetic sensor 23 itself also has a magnetic field, and the deformation of the magnetic sensor 23 will affect the magnetic field of the permanent magnet 33, causing a change in the magnetic field of the permanent magnet 33, which in turn induces a current in the coil. Based on this characteristic, the state of the blood can be reflected.

[0049] For details, please refer to Figure 7 It shows the four states of the coagulation test over time:

[0050] After the blood to be tested is added to the cup 21, the squeezing device 10 is still in the high position and has not squeezed the blood. Set this as the initial state, that is, the position shown in (i).

[0051] The squeezing device 10 reciprocates to squeeze the blood according to the set parameters, and captures one state point, which is shown in position (ii). The convex spherical end contacts the blood, and the blood is squeezed; however, since the blood is still in a liquid state at this time, it can rise through the gap between the convex spherical end and the inner wall of the cup 21. Therefore, although the bottom magnetic sensor 23 has a deformation, the deformation is not large, that is, the distance between the magnetic sensor 23 and the permanent magnet 33 is not large, and the induced current generated is also not large.

[0052] As time progresses, the blood gradually coagulates from a liquid state to a solid state. The squeezing device 10 continues to squeeze the blood repeatedly according to the same set parameters, capturing one state point, as shown in position (iii). Similar to (ii), the convex spherical end contacts the blood, and the blood is squeezed. Unlike (ii), because the blood is solid, it can no longer rise through the gap; although the pressure on the magnetic sensor 23 remains unchanged, the inability of the blood to rise causes the deformation of the magnetic sensor 23 to increase, and the distance between the magnetic sensor 23 and the permanent magnet 33 gradually decreases. Thus, as the degree of blood solidification reaches its maximum, the distance between the magnetic sensor 23 and the permanent magnet 33 reaches its minimum, causing the induced current to reach its peak.

[0053] As time progresses, the blood begins to fibrinoly dissolve and changes from a solid to a liquid state. The squeezing device 10 continues to squeeze the blood repeatedly according to the same set parameters, capturing one state point, as shown in position (vi). Similar to (ii), the blood can rise through the gap between the convex spherical end and the inner wall of the cup 21; therefore, compared to (iii), the magnetic sensor 23 retracts, its deformation decreases, the distance between the magnetic sensor 23 and the permanent magnet 33 increases, and the induced current decreases.

[0054] Then, the extrusion device 10 is returned to the high position, that is, back to the initial state.

[0055] Thus, the blood undergoes the entire process of changing from a liquid state to a solid state and then fibrinoly back to a liquid state. The induced current generated corresponds to this process, and the magnitude of the induced current reflects the magnitude of the thrombus elasticity in real time, which can be used to diagnose the patient's blood condition.

[0056] For the measuring device: The measuring device is connected to the coil to acquire the generated induced current and process it into a thromboelastography map. The measuring device includes a data acquisition module and a processing module. The data acquisition module is used to acquire the induced current generated by the coil and transmit the induced current to the processing module. The processing module can be a host computer such as an industrial control computer to process the induced current into a thromboelastography map.

[0057] In addition, the blood needs to be kept at a constant temperature during coagulation testing: for example, by placing the thromboelastography instrument in a constant temperature environment; or by adding a heat preservation device to the outside of the blood storage device; or by applying a heat preservation coating to the outer wall of the cup 21, so as to ensure that the temperature is kept at 37°C during the thromboelastography test.

[0058] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0059] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this invention patent should be determined by the appended claims.

Claims

1. A thromboelastography instrument based on magnetic induction, characterized in that, include: A blood storage device includes a base, a housing, and a connecting assembly; the connecting assembly is used to detachably connect the housing and the base; a permanent magnet containing a coil is disposed inside the base; the housing includes a cup and a magnetic sensor; one end of the cup is provided with an opening for adding blood to be tested into the cup; the other end of the cup is provided with a magnetic sensor for sensing the pressure from the blood to be tested, causing deformation, and cooperating with the permanent magnet to induce a current in the coil; A squeezing device extends into the cup body from the opening of the cup body; there is a gap between the end of the squeezing device extending into the cup body and the inner wall of the cup body; the squeezing device is used to reciprocate to squeeze the blood to be tested, and the blood to be tested acts on the magnetic sensor. as well as A measuring device, connected to a coil, is used to acquire the generated induced current and process it into a thromboelastogram.

2. The thromboelastography instrument based on magnetic induction according to claim 1, characterized in that, The base includes: The base has a groove on the side facing the shell; as well as A positioning piece is provided on the side of the base facing the housing; the side of the positioning piece facing the base is provided with a groove. The base and the positioning plate are integrated into one piece, so that groove one and groove two form a storage cavity to accommodate the permanent magnet.

3. The thromboelastography instrument based on magnetic induction according to claim 2, characterized in that, The positioning plate and the base are provided with corresponding positioning holes and are connected as one unit by locking screws.

4. The thromboelastography instrument based on magnetic induction according to claim 1, characterized in that, The connection component includes: The buckle is located at the other end of the cup body and supports the magnetic sensor from the outer edge; as well as The female buckle is located on the side of the positioning piece facing the housing; the female buckle is provided with a connecting hole, and the male buckle is inserted into the connecting hole and detachably connected to the female buckle.

5. The thromboelastography instrument based on magnetic induction according to claim 4, characterized in that, The male buckle has a slot on its side, and a retractable locking block is provided on the inner ring of the connecting hole; the female buckle has a spring switch to control the extension and retraction of the locking block, and thus cooperate with the slot to realize the detachable connection between the male buckle and the female buckle.

6. The thromboelastography instrument based on magnetic induction according to claim 4 or 5, characterized in that, The side of the buckle facing the housing has a mounting groove for placing the magnetic sensor; the other end of the cup body presses the magnetic sensor into the mounting groove through a gasket; the center of the mounting groove has a through hole to provide space for the deformation of the magnetic sensor.

7. The thromboelastography instrument based on magnetic induction according to claim 2, characterized in that, The side of the positioning piece facing the housing has a second through hole, which communicates with the second groove.

8. The thromboelastography instrument based on magnetic induction according to claim 1, characterized in that, The distance between the magnetic sensor and the base is 5~8mm.

9. The thromboelastography instrument based on magnetic induction according to claim 1, characterized in that, The end of the extrusion device that extends into the cup is convex spherical, and the gap between its maximum diameter and the inner wall of the cup is 1~1.5mm.

10. The thromboelastography instrument based on magnetic induction according to claim 1, characterized in that, The blood storage device is also equipped with a temperature control device to maintain a stable temperature in the blood storage device.

Images