A traditional Chinese medicine composition for treating pain and discomfort caused by cervical and lumbar intervertebral disc herniation
By using traditional Chinese medicine compositions composed of drugs such as Shengma and Chaihu, the Qi and the Du meridian are unblocked, and the "Chaoqi Jigong Decoction" is formed, which solves the problem of pain and discomfort in the cervical and lumbar disc herniation, and effectively relieves pain and improves the quality of life.
Patent Information
- Application Number
- CN202311463297.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-11-06
- Publication Date
- 2025-06-17
- Estimated Expiration
- 2043-11-06
AI Technical Summary
The pain and discomfort caused by cervical and lumbar disc herniation, the existing treatment methods have problems such as high trauma, high risk, long recovery period, and high cost, and lack effective conservative treatment methods.
A traditional Chinese medicine composition is proposed, including Shengma, Bupleurum, Chicken Blood Vine, Honeysuckle Vine, Atractylodes, White Peony, Oyster, Chicken Neijin, Achyranthes pungent, Eucommia ulmoides, Dog Ridge and Rehmannia glutinosa. Through the treatment method of regulating the qi and opening the Du meridian, "Cheqi Jigong Decoction" is formed to treat pain and discomfort caused by herniated cervical and lumbar discs.
This traditional Chinese medicine composition can effectively improve the pain and discomfort symptoms of patients with cervical and lumbar disc herniation. After about one week, it will be effective and significantly improved about four weeks. After one month of conservative treatment every six months, it can greatly alleviate the pain of the patient, improve the quality of life, enable the patient to return to society, and restore the normal lifestyle.
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Figure CN117257875B_ABST
Abstract
Description
Technical Field
[0001] The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating pain and discomfort caused by cervical and lumbar disc herniation. Background Art
[0002] Cervical and lumbar disc herniation is a syndrome characterized by pain in the neck, waist, and neck and lower back regions as the main symptoms clinically. After the cervical and lumbar intervertebral discs undergo degenerative changes, part or all of the annulus fibrosus ruptures, and the nucleus pulposus protrudes outward alone or together with the annulus fibrosus and the cartilaginous endplate, resulting in irritation or compression of the sinuvertebral nerve and nerve roots. With the development of science and the improvement of living standards, people's work patterns have changed and electronic products have been widely used, resulting in an increasing incidence of neck and low back pain, and the onset age is getting younger. Approximately 70% of people will experience this pain in their lifetime.
[0003] Globally, neck and low back pain has become one of the four main causes of physical disability. Low back pain is more related to the potential loss of functional status in the workforce, making the persistent existence of low back pain worrying. Due to the long course and repeated attacks of this disease, the work and quality of life of patients are severely affected. However, its etiology and pathogenesis have not been fully understood yet, and there is no specific treatment method. Clinically, the treatment methods for neck and low back pain can be roughly divided into surgical treatment and conservative treatment. Surgical treatment has large trauma, high risk, many contraindications, a long postoperative recovery period, and high costs. Most patients are not easily willing to accept it immediately. Research also shows that the lumbar function limitation and pain degree of patients with social and economic disadvantages are worse than those of patients with better economic conditions. Kim et al. found that although the short-term effect of conservative treatment is not as obvious as that of surgical treatment, the symptom relief is enhanced in the medium and long term. The guideline level 1 recommends that conservative treatment should be the first choice for patients with lumbar disc herniation without significant nerve damage. The protruding intervertebral disc usually shows varying degrees of atrophy over time, and the clinical function is improved. The success rate of conservative treatment is about 80-90%. Therefore, it is particularly urgent and important to seek a conservative treatment method with high efficacy, few side effects, little damage, and low cost.
[0004] Conservative treatment is recommended at level 1 in the guidelines for cervical and lumbar disc herniation, and traditional Chinese medicine treatment of LDH is one of the main methods in conservative treatment. Traditional Chinese medicine treatment has shown good clinical efficacy in clinical practice and has long-term efficacy. Currently, the main traditional Chinese medicine therapies applied clinically include: oral administration of traditional Chinese medicine, acupuncture, massage, traditional Chinese medicine pack application, acupoint application, etc. Although traditional Chinese medicine treatment cannot significantly affect the MRI morphology change of LDH, it can effectively relieve the clinical symptoms of LDH and has obvious effects on aspects such as the regression of edema, the release of adhesions, and the absorption of inflammatory exudates after nerve compression in the spinal canal. The results of systematic reviews show that traditional Chinese medicine treatment has high safety, and the comprehensive traditional Chinese medicine treatment effect is relatively better than that of single treatment.
[0005] Through more than 20 years of clinical practice, the concept of comprehensive consideration has been put forward in the conservative treatment of pain and discomfort caused by cervical and lumbar disc herniation, that is, "one should not simply relieve pain but also address the root cause". The formation of pain and discomfort caused by cervical and lumbar disc herniation is related to various factors such as muscles, ligaments, discs, and joint nutrition. In the syndrome differentiation and treatment of traditional Chinese medicine, innovative concepts are emphasized, with focus on the treatment of the liver, kidney, spleen, and stomach, forming a treatment plan with distinct traditional Chinese medicine characteristics. Based on the holistic concept of traditional Chinese medicine, attention is paid to the smooth flow of qi in the Governor Vessel and the cultivation of the functions of internal organs.
[0006] In view of this, in the clinical diagnosis and treatment process, the present invention breaks new ground and proposes a new traditional Chinese medicine composition for treating pain and discomfort caused by cervical and lumbar disc herniation. By applying the treatment method of "regulating qi and dredging the Governor Vessel" and formulating the "Qi-Regulating and Pain-Relieving Decoction" by itself, good clinical curative effects have been achieved in the treatment of pain and discomfort caused by cervical and lumbar disc herniation. Summary of the Invention
[0007] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating pain and discomfort caused by cervical and lumbar disc herniation. With regulating qi and relieving pain as the core, this composition can effectively improve the symptoms of pain and discomfort caused by cervical and lumbar disc herniation.
[0008] In order to achieve the above purpose, the technical solution adopted is as follows:
[0009] A traditional Chinese medicine composition for treating pain and discomfort caused by cervical and lumbar disc herniation, comprising: Cimicifuga foetida, Bupleurum chinense, Spatholobus suberectus, Lonicera japonica Thunb., Atractylodes macrocephala, Paeonia lactiflora, Oyster, Endothelium Corneum Gigeriae Galli, Achyranthes bidentata, Eucommia ulmoides, Cibotium barometz, Rehmannia glutinosa.
[0010] Furthermore, it comprises the following raw materials in parts by weight:
[0011] 5 - 9 parts of Cimicifuga foetida, 5 - 9 parts of Bupleurum chinense, 9 - 15 parts of Spatholobus suberectus, 9 - 15 parts of Lonicera japonica Thunb., 12 - 20 parts of Atractylodes macrocephala, 12 - 20 parts of Paeonia lactiflora, 20 - 30 parts of Oyster, 9 - 15 parts of Endothelium Corneum Gigeriae Galli, 15 - 20 parts of Achyranthes bidentata, 9 - 15 parts of Eucommia ulmoides, 9 - 12 parts of Cibotium barometz, 20 - 30 parts of Rehmannia glutinosa.
[0012] Still further, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 5 parts of Cimicifuga foetida, 5 parts of Bupleurum chinense, 9 - 12 parts of Spatholobus suberectus, 9 - 12 parts of Lonicera japonica Thunb., 12 - 20 parts of Atractylodes macrocephala, 12 - 20 parts of Paeonia lactiflora, 20 - 30 parts of Oyster, 9 - 12 parts of Endothelium Corneum Gigeriae Galli, 15 parts of Achyranthes bidentata, 9 - 12 parts of Eucommia ulmoides, 9 - 12 parts of Cibotium barometz, 20 - 30 parts of Rehmannia glutinosa.
[0013] Furthermore, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 5 parts of cimicifuga, 5 parts of bupleurum, 9 parts of suberect spatholobus stem, 9 parts of honeysuckle stem, 15 parts of atractylodes macrocephala, 15 parts of white peony root, 20 parts of oyster, 9 parts of chicken gizzard-membrane, 15 parts of achyranthes root, 9 parts of eucommia bark, 9 parts of cibot rhizome, and 20 parts of prepared rehmannia root.
[0014] Furthermore, the traditional Chinese medicine composition is a traditional Chinese medicine composition in the form of decoction.
[0015] Compared with the prior art, the beneficial effects of the present invention are as follows:
[0016] Cervical and lumbar disc herniation has a long course and recurs frequently, seriously affecting the work and quality of life of patients. However, there is still no effective treatment method for it. The guideline recommends at level 1 that conservative treatment should be the first choice for patients with cervical and lumbar disc herniation without significant nerve damage. And the traditional Chinese medicine listed in the present invention has distinct unique features in the treatment of this disease.
[0017] The traditional Chinese medicine composition of the present invention takes regulating qi and relieving pain as the core, and is an effective prescription used in the clinical treatment of lumbar disc herniation for more than twenty years. Among them, in the conservative treatment of cervical and lumbar diseases, the concept of "not being able to relieve pain only by treating the symptoms, but should consider comprehensively" is followed. In the present invention, through innovation in the syndrome differentiation and treatment of traditional Chinese medicine, attention is paid to the treatment of the liver, kidney and spleen and stomach, forming a treatment plan with distinct traditional Chinese medicine characteristics. Based on the overall concept of traditional Chinese medicine, attention is paid to the smooth flow of qi in the governor vessel, and at the same time, the cultivation of zang-fu organ functions is taken into account, thus forming the core drugs of the qi-regulating and pain-relieving decoction. This traditional Chinese medicine composition can effectively improve the pain and discomfort symptoms of patients with cervical and lumbar diseases. The effect can be seen after about one week, and it is significantly improved after about four weeks. Through conservative treatment for one month every six months, it can well relieve the pain of patients, improve and enhance the quality of life of patients, enable patients to return to society and resume a normal lifestyle. Description of the Drawings
[0018] Figure 1 The syndrome type composition of patients using the decoction of the traditional Chinese medicine composition of the present invention during hospitalization;
[0019] Figure 2 The gender composition of LDH patients treated with the decoction of the traditional Chinese medicine composition of the present invention;
[0020] Figure 3 The age and gender composition of LDH patients using the decoction of the traditional Chinese medicine composition of the present invention. Detailed Embodiments
[0021] In order to further elaborate on a traditional Chinese medicine composition for treating pain and discomfort caused by cervical and lumbar intervertebral disc herniation of the present invention and achieve the expected invention purpose, the following, in combination with preferred embodiments, details the specific implementation manner, structure, characteristics and efficacy of a traditional Chinese medicine composition for treating cervical and lumbar diseases proposed according to the present invention. In the following description, different "one embodiment" or "embodiment" do not necessarily refer to the same embodiment. In addition, specific features, structures or characteristics in one or more embodiments can be combined in any suitable form.
[0022] Before elaborating in detail on a traditional Chinese medicine composition for treating pain and discomfort caused by cervical and lumbar intervertebral disc herniation of the present invention, it is necessary to further explain the related materials mentioned in the present invention to achieve better effects.
[0023] Rhizoma Cimicifugae, alias: Zhou Shengma (in "Shennong Ben Cao Jing"), Zhou Ma (in "Bie Lu"), Chicken Bone Shengma (by Tao Hongjing), Ghost Face Shengma (in "Compendium of Materia Medica"), is the dried rhizome of the Ranunculaceae plant Cimicifuga heracleifolia Kom., Cimicifuga dahurica (Turcz.) Maxim. or Cimicifuga foetida L. It is dug in autumn, the sediment is removed, and when the fibrous roots are dry after drying in the sun, the fibrous roots are singed off or removed, and then dried. Rhizoma Cimicifugae belongs to the lung, spleen, stomach and large intestine meridians, is pungent and slightly sweet in taste, and slightly cold in nature. Rhizoma Cimicifugae has the effects of inducing sweating and rash, clearing heat and detoxifying, and lifting yang qi, and is used for wind-heat headache, toothache, oral ulcer, sore throat, measles not showing, yang toxin macula, rectal prolapse, and uterine prolapse.
[0024] Radix Bupleuri, alias: Di Xun, Zi Hu (in "Shennong Ben Cao Jing"), Shan Cai, Ru Cao (in "Wu Pu Ben Cao"), Chai Cao (in "Pin Hui Jing Yao"), is the dried root of the Umbelliferae plant Bupleurum chinense DC. or Bupleurum scorzonerifolium Willd. Radix Bupleuri belongs to the liver and gallbladder meridians, is bitter in taste, and slightly cold in nature, and has the effects of reconciling shaoyang, soothing the liver and lifting yang, and is used for common cold with fever, alternating chills and fever, distending pain in the chest and hypochondrium, irregular menstruation, uterine prolapse, and rectal prolapse.
[0025] Caulis Spatholobi, alias: Xue Feng Teng (in "Chinese Pharmacopoeia"), is the dried vine stem of the Leguminosae plant Spatholobus suberectus Dunn. It is produced in various mountainous counties in our province, and is produced more in the northern and northwestern regions of Guangdong. Caulis Spatholobi is bitter and sweet in taste, warm in nature, and belongs to the liver and kidney meridians, and has the effects of promoting blood circulation and nourishing blood, regulating menstruation and relieving pain, and relaxing tendons and activating collaterals, and is used for irregular menstruation, dysmenorrhea, amenorrhea, rheumatic arthralgia, numbness and paralysis, and blood deficiency and sallow complexion.
[0026] Honeysuckle Stem, the stem and branch of Lonicera japonica Thunb., Lonicera confusa DC., Lonicera hypoglauca Miq., Lonicera fulvotomentosa Hsu et S. C. Cheng, etc. of the Caprifoliaceae family. Honeysuckle Stem, sweet in taste and cold in nature, belongs to the lung and stomach meridians, and has the effects of clearing heat and detoxifying, dispersing wind and dredging collaterals, and is used for febrile diseases, dysentery with heat-toxin, carbuncles and sores, rheumatic heat arthralgia, and red, swollen, hot and painful joints.
[0027] Atractylodes Macrocephala Koidz., alias: Mountain Thistle, Yangbao Thistle (in "Erya"), Atractylodes (in "Shennong Ben Cao Jing"), Tianji (in "Wu Pu Ben Cao"), Mountain Ginger (in "Guang Ya"), Qiligal (in "Southern Grass and Tree Records"), Mountain Essence (in "Shen Yao Jing"), Mountain Coptis (in "Bie Lu"), Winter Atractylodes Macrocephala (in "De Pei Ben Cao"), is the dried rhizome of the perennial herb Atractylodes macrocephala Koidz. of the Compositae family. It is mostly cultivated and there are also wild ones. It is dug when the lower leaves wither in winter and the upper leaves become brittle, remove the sediment, dry it by baking or in the sun, and then remove the fibrous roots. Atractylodes Macrocephala Koidz., sweet and bitter in taste, slightly warm in nature, belongs to the spleen and stomach meridians, and has the effects of replenishing middle qi, strengthening the spleen and stomach, drying dampness and promoting diuresis, stopping vomiting and diarrhea, stopping sweating, and preventing miscarriage, and is used for indigestion, edema and distension, vomiting, diarrhea, dysentery, fetal restlessness, spontaneous sweating due to physical weakness, etc. caused by deficiency of middle qi and poor spleen transportation.
[0028] White Peony Root, alias: Golden Peony Root (in "An Qisheng's Alchemy Method"), White Peony Root (in "Drug Transformation"), slightly cold in nature, bitter, sour and sweet in taste, belongs to the liver and spleen meridians, and has the effects of calming the liver and relieving pain, nourishing blood and regulating menstruation, astringing yin and stopping sweating, and is used for headache and dizziness, hypochondriac pain, abdominal pain, spasms and pain of the extremities, sallow complexion due to blood deficiency, irregular menstruation, spontaneous sweating, and night sweating.
[0029] Oyster, alias: Oyster Clam (in "Shennong Ben Cao Jing"), Ancient Ben (in Yang Fu's "Record of Strange Things"), Left-facing Oyster (in "Supplementary Elbow Prescription"), Oyster (in "Bie Lu"), Oyster Shell, Oyster Seedling (in "Illustrated Classic of Materia Medica"), Oyster Shell (in "Manual of Traditional Chinese Medicine in Zhejiang"), Left Shell (in "Chinese Materia Medica"), slightly cold in nature, salty in taste, belongs to the liver, gallbladder and kidney meridians, and has the effects of calming the mind with heavy substances, suppressing yang and nourishing yin, stopping sweating and astringing essence, softening hardness and dissipating nodules, and is used to treat epilepsy, dizziness, spontaneous sweating, night sweating, spermatorrhea, turbid urine, metrorrhagia and leukorrhea, scrofula, goiter, and is used for palpitation and insomnia, dizziness and tinnitus, scrofula and phlegm nodules, abdominal masses, spontaneous sweating and night sweating, spermatorrhea, metrorrhagia and leukorrhea, stomachache and acid regurgitation.
[0030] Endothelium Corneum Gigeriae Galli, alias: Inner Yellow Skin of Chicken Gizzard (in "Shennong Ben Cao Jing"), Chicken Gizzard Skin (in "Collected Annotations to the Classic of Materia Medica"), Inner Yellow Skin of Chicken Gizzard (in "Japanese Pharmacopoeia"), Chicken Gizzard Skin (in "Compendium of Materia Medica in Yunnan"), Chicken Yellow Skin (in "Modern Practical Chinese Medicine"), Chicken Food Skin (in "Handbook of Traditional Chinese Medicine in Henan"), Chicken Crop (in "Medicinal Materials in Xinjiang"), Chicken Comb (in "Traditional Chinese Medicine in Shandong"), Chicken Middle Gold, Stone Gallbladder for Resolving Stones, Bone-dissolving Gallbladder (in "Shanxi Traditional Chinese Medicine Annals"), is the dried inner wall cortex of the gizzard of various chickens of the Phasianidae family. Endothelium Corneum Gigeriae Galli, sweet in taste, neutral in nature, belongs to the spleen and stomach meridians, and has the effects of regulating the spleen and stomach, promoting digestion and removing accumulation, and is mainly used for indigestion, vomiting, diarrhea, infantile malnutrition, etc.
[0031] Achyranthes bidentata, also known as Huai Achyranthes bidentata, Ox Knee, Mountain Amaranth, Joint Grass, Red Achyranthes bidentata, Du Achyranthes bidentata, and Wild Achyranthes bidentata, is the dried root of the plant Achyranthes bidentata Blume of the Amaranthaceae family. It is dug up when the stems and leaves wither in winter, the fibrous roots and sediment are removed, bundled into small bundles, dried until wrinkled, then the top is cut even and dried in the sun. Achyranthes bidentata enters the liver and kidney meridians, is bitter and sour in taste, and neutral in nature. It has the effects of tonifying the liver and kidney, strengthening tendons and bones, removing blood stasis and dredging meridians, and guiding blood downward. It is used for soreness of the waist and knees, weakness of tendons and bones, amenorrhea and mass, and dizziness due to hyperactivity of liver yang.
[0032] Eucommia ulmoides, also known as Sizhong, Sixian, Silk-pulling Bark, Stone Sixian, Cotton Tree, Mian, Sixian, and Silk-connected Bark, is the dried bark of the plant Eucommia ulmoides of the Eucommiaceae family. Eucommia ulmoides is pungent and sweet in taste, enters the liver and kidney meridians, and has the effects of tonifying the liver and kidney, strengthening tendons and bones, and preventing miscarriage. It is used for deficiency of the liver and kidney, soreness of the waist and knees, weakness of tendons and bones, dizziness, vaginal bleeding during pregnancy, and threatened abortion.
[0033] Cibotium barometz, also known as Golden-haired Cibotium barometz, Golden-haired Dog, Golden Cibotium barometz, Golden-haired Lion, Monkey-haired Head, and Yellow Dog Head, is the dried rhizome of the plant Cibotium barometz of the Dicksoniaceae family. Cibotium barometz is bitter and sweet in taste, warm in nature, and enters the liver and kidney meridians. It has the effects of dispelling wind-dampness, tonifying the liver and kidney, and strengthening the waist and knees. It is mainly used for rheumatic arthralgia, weakness of the waist and knees, weakness of the lower limbs, frequent urination, enuresis, excessive leucorrhea, and external application for stopping bleeding from traumatic injuries.
[0034] Prepared Rehmannia Root, also known as Prepared Rehmannia Root and Large Prepared Rehmannia Root, is sweet in taste and slightly warm in nature, and enters the liver and kidney meridians. It is heavy. Prepared Rehmannia Root has the effects of tonifying, nourishing yin and blood, replenishing essence and marrow, and tonifying the kidney. It is used for yin deficiency of the liver and kidney, soreness of the waist and knees, steaming bone with fever, night sweats and spermatorrhea, internal heat and thirst, sallow complexion due to blood deficiency, palpitation, irregular menstruation, metrorrhagia and metrostaxis, dizziness, tinnitus, and premature whitening of hair.
[0035] After understanding the relevant materials mentioned in the present invention, the following will further introduce in detail a traditional Chinese medicine composition for treating pain and discomfort caused by cervical and lumbar disc herniation according to the present invention in combination with specific embodiments:
[0036] Through more than 20 years of clinical practice, the applicant has put forward the concept that in the treatment of cervical and lumbar diseases, "one should not just relieve pain symptomatically but also consider comprehensively". The formation of cervical and lumbar diseases is related to various factors such as muscles, ligaments, intervertebral discs and joint nutrition. Therefore, in the treatment based on syndrome differentiation of traditional Chinese medicine, innovative concepts are adopted, with emphasis on the treatment of the liver, kidney and spleen-stomach, thus forming a treatment plan with distinct characteristics of traditional Chinese medicine. The liver governs tendons, the kidney governs bones, and the spleen governs muscles. Pathogenic factors acting on the body can lead to deficiency of the spleen-qi, deficiency of the liver and kidney in the human body, resulting in the lack of postnatal biochemical source and the loss of nourishment for the muscles and bones, and thus diseases occur. The combination of internal and external factors leads to the occurrence of cervical and lumbar diseases. Therefore, in the clinical diagnosis and treatment process, a new approach is taken, fully emphasizing the role of qi movement in the treatment of cervical and lumbar diseases. The self-prescribed "Qi-Regulating and Pain-Relieving Decoction (i.e., the technical solution of the present invention)" has achieved good clinical efficacy in the treatment of cervical and lumbar diseases. For cervical and lumbar diseases mainly manifested by early symptoms such as simple pain and discomfort, good clinical treatment effects have been obtained, and pain can be well relieved. More than 1,000 patients have benefited in just the past decade.
[0037] The Governor Vessel runs through the spine and pertains to the kidney, being the sea of yang meridians, with the functions of promoting qi and blood circulation and transporting essence. The prosperity and decline of the qi of the Governor Vessel and the smoothness of its qi are crucial for the smooth flow of qi and blood in each meridian and the functions of the zang-fu organs. In the academic thought of "the circulation of qi in a cycle" put forward by Huang Yuanyu, a court physician in the Qing Dynasty, the ascending and descending of the liver and gallbladder are one of the keys to maintaining the up-and-down movement of yang qi. Therefore, Bupleurum and Rhizoma Cimicifugae are used as the monarch drugs in this formula. Bupleurum and Rhizoma Cimicifugae are from "Shennong's Classic of Materia Medica" and have a long history of medicinal use. They are also very important drugs in Buzhong Yiqi Decoction. Bupleurum has a pungent and bitter taste and a slightly cold nature, with the effects of relieving exterior syndrome and fever, soothing the liver and relieving depression, lifting yang and raising the sinking, etc., and is the essential drug for treating Shaoyang syndrome and stagnation of liver qi. And "Compendium of Materia Medica" states that it can "lead the clear qi of Shaoyang upward" and raise the qi of the liver yang. Rhizoma Cimicifugae has a pungent and slightly sweet taste and a slightly cold nature, with the effects of inducing eruption, clearing heat and detoxifying, lifting yang qi, etc. Bupleurum and Rhizoma Cimicifugae in this formula are taken in the sense of "wind drugs for lifting yang". Because of their ascending and dispersing properties, they can rise and float upward and arouse yang qi. Bupleurum mainly rises the clear qi of Shaoyang, and Rhizoma Cimicifugae mainly leads the clear qi of Yangming upward. The two are used in combination to jointly achieve the effects of rising and generating the clear yang and regulating qi movement. In terms of the dosage of the medicine, considering that wind drugs cannot rise and float without being light and clear, small doses of Bupleurum and Rhizoma Cimicifugae are given to conform to the nature of the rising and floating of yang qi and jointly perform the function of lifting yang qi. In the prescription application of Rhizoma Cimicifugae and Bupleurum, although the dosage is small, their great use in regulating qi movement in the prescription is considered. Without these two drugs, only the subsequent drugs for tonifying the liver and kidney and strengthening the spleen and muscles cannot complete the regulation of the qi movement of the Governor Vessel and improve the symptoms of pain and discomfort in the cervical and lumbar regions. Therefore, they are used as the monarch drugs.
[0038] Secondly, the waist is the organ of the kidney. The kidney stores essence and governs bones, the liver stores blood and governs tendons, and the spleen governs the limbs and muscles. Therefore, Eucommia ulmoides, Achyranthes bidentata, Rehmannia glutinosa, Paeonia lactiflora, Cibotium barometz, and Atractylodes macrocephala are used as ministerial drugs. In the formula, Eucommia ulmoides combined with Achyranthes bidentata enters the liver and kidney meridians and is a pair of drugs for tonifying the liver and kidney and strengthening the bones and muscles. Eucommia ulmoides mainly acts on the qi aspect and is good at tonifying the kidney qi. Achyranthes bidentata mainly acts on the blood aspect and is partial to promoting blood circulation and dredging meridians. The combination of the two can take into account both qi and blood, doubling the power of tonifying the liver and kidney and strengthening the bones and muscles. At the same time, Rehmannia glutinosa is added to enter the kidney to replenish essence and marrow, and Paeonia lactiflora is added to enter the liver to astringe yin and nourish blood. The combination of the two can achieve the effects of replenishing essence and blood, mutual generation of essence and blood, and simultaneous treatment of the liver and kidney. In addition, Cibotium barometz is added. This medicine is recorded in "Shennong Ben Cao Jing" and has the effects of tonifying the liver and kidney, strengthening the lumbar spine, dispelling wind-dampness, and promoting joint movement. It mainly treats lumbar and dorsal stiffness, joint relaxation, general arthralgia due to cold-dampness, and knee pain. It can not only assist Eucommia ulmoides and Achyranthes bidentata in tonifying the liver and kidney and strengthening the lumbar spine, but also assist Bupleurum chinense and Cimicifuga foetida in lifting the yang qi of the governor vessel. Another Atractylodes macrocephala enters the spleen and stomach meridians and has the effects of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis. It can tonify the spleen qi and assist the spleen in transportation, achieving the effect of strengthening the spleen and replenishing qi and increasing muscle mass. And, it is mentioned in "Tang Ye Ben Cao" that "Atractylodes macrocephala enters the shaoyin meridian" and "promotes blood in the waist and umbilical region and dredges the water passages"; there is also a saying in "Medical Congregation Record" that "Atractylodes macrocephala can promote the dead blood in the lumbar muscles. For low back pain ineffective with other drugs, the effect is miraculous when using Atractylodes macrocephala"; therefore, Atractylodes macrocephala can also promote qi and blood in the waist and umbilical region, making the qi and blood circulate smoothly, and smooth circulation leads to pain relief.
[0039] In addition, the adjuvant drugs are combined with Endothelium Corneum Gigeriae Galli, Oyster, Spatholobus suberectus, and Lonicera japonica. Endothelium Corneum Gigeriae Galli is good at strengthening the stomach and promoting digestion, and can assist Atractylodes macrocephala to enhance the effect of strengthening the spleen and replenishing qi; and because it is mentioned in "Medical Compendium of the Golden Chamber and Western Medicine" that Endothelium Corneum Gigeriae Galli "is good at removing stasis and blood", it can assist Achyranthes bidentata to enhance the effect of promoting blood circulation and removing blood stasis. Oyster is salty and slightly cold, and has the effects of calming the mind with heavy substances, suppressing yang and nourishing yin, softening hardness and dissipating nodules, astringing and consolidating, etc. In the formula, the effect of suppressing yang and nourishing yin of Oyster is taken. On the one hand, it can assist Rehmannia glutinosa and Paeonia lactiflora to nourish yin and blood, on the other hand, it can assist Achyranthes bidentata and Endothelium Corneum Gigeriae Galli to promote blood circulation and disperse stasis, and thirdly, it can suppress yang and calm the mind to prevent excessive ascending of Bupleurum chinense and Cimicifuga foetida.
[0040] Finally, according to the traditional Chinese medicine theory, "liana enters the collaterals", so by analogy, liana drugs are combined to soothe the muscles and tendons, dredge the collaterals and relieve pain. Among them, Spatholobus suberectus is warm and flat in nature. It can not only soothe the muscles and tendons and dredge the collaterals, but also promote blood circulation and nourish blood, and has obvious effects on pain caused by blood stasis in the blood vessels and obstruction of the collaterals by arthralgia. Lonicera japonica, sweet and cold in taste, has the effects of clearing heat and detoxifying, dispelling wind and dredging collaterals. "Compendium of Materia Medica" records that Lonicera japonica "treats all rheumatism and various swelling and pain". Therefore, the combination of the two can promote blood circulation, soothe the muscles and tendons, dredge the collaterals and relieve pain.
[0041] This prescription is composed of Bupleurum chinense, Cimicifuga foetida, Spatholobus suberectus, Lonicera japonica, Atractylodes macrocephala, Paeonia lactiflora, Oyster, Endothelium Corneum Gigeriae Galli, Achyranthes bidentata, Eucommia ulmoides, Cibotium barometz, Rehmannia glutinosa and other drugs. Looking at the whole prescription, there is both ascending and descending, can defend and attack, regulates qi and blood, treats the liver, spleen and kidney simultaneously. The combination of various drugs enables the qi movement of the governor vessel to be smooth, the liver and kidney to be nourished, and the spleen and stomach to be strengthened and transported. The whole prescription together achieves the effects of lifting yang and dredging the governor vessel, strengthening the spleen and tonifying the kidney. Thus, the Qi-Regulating and Pain-Relieving Decoction has achieved good clinical treatment effects for early symptoms such as simple pain and discomfort in cervical and lumbar spine diseases.
[0042] The technical solution of the present invention is as follows:
[0043] A traditional Chinese medicine composition for treating pain and discomfort caused by cervical and lumbar intervertebral disc herniation, comprising: rhizoma cimicifugae, bupleurum root, millettia reticulata benth, honeysuckle stem, atractylodes macrocephala, white peony root, oyster, chicken gizzard-membrane, achyranthes bidentata, eucommia ulmoides, cibotium barometz, and rehmannia glutinosa.
[0044] Preferably, it comprises the following raw materials in parts by weight:
[0045] 5-9 parts of rhizoma cimicifugae, 5-9 parts of bupleurum root, 9-15 parts of millettia reticulata benth, 9-15 parts of honeysuckle stem, 12-20 parts of atractylodes macrocephala, 12-20 parts of white peony root, 20-30 parts of oyster, 9-15 parts of chicken gizzard-membrane, 15-20 parts of achyranthes bidentata, 9-15 parts of eucommia ulmoides, 9-12 parts of cibotium barometz, and 20-30 parts of rehmannia glutinosa.
[0046] More preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 5 parts of rhizoma cimicifugae, 5 parts of bupleurum root, 9-12 parts of millettia reticulata benth, 9-12 parts of honeysuckle stem, 12-20 parts of atractylodes macrocephala, 12-20 parts of white peony root, 20-30 parts of oyster, 9-12 parts of chicken gizzard-membrane, 15 parts of achyranthes bidentata, 9-12 parts of eucommia ulmoides, 9-12 parts of cibotium barometz, and 20-30 parts of rehmannia glutinosa.
[0047] More preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 5 parts of rhizoma cimicifugae, 5 parts of bupleurum root, 9 parts of millettia reticulata benth, 9 parts of honeysuckle stem, 15 parts of atractylodes macrocephala, 15 parts of white peony root, 20 parts of oyster, 9 parts of chicken gizzard-membrane, 15 parts of achyranthes bidentata, 9 parts of eucommia ulmoides, 9 parts of cibotium barometz, and 20 parts of rehmannia glutinosa.
[0048] Preferably, the traditional Chinese medicine composition is a decoction.
[0049] Example 1.
[0050] Prescription: 8 g of rhizoma cimicifugae, 8 g of bupleurum root, 10 g of millettia reticulata benth, 10 g of honeysuckle stem, 12 g of atractylodes macrocephala, 12 g of white peony root, 25 g of oyster, 10 g of chicken gizzard-membrane, 18 g of achyranthes bidentata, 10 g of eucommia ulmoides, 10 g of cibotium barometz, and 25 g of rehmannia glutinosa.
[0051] Preparation and administration: Decoct with water to obtain 200 ml of juice, and take it in two divided doses, morning and evening.
[0052] Application:
[0053] Typical application case 1:
[0054] Patient information: Fang Moumou, male, 55 years old, a geographical information collector.
[0055] Symptoms: Lumbar disc herniation. In May 2015, due to the obvious pain during the onset of the disease, MRI showed disc herniation at L4-5 and L5-S1. Conservative treatment in many hospitals in Changji and other places did not work for more than two months. There was slight muscle atrophy in the lower limbs. Many hospitals recommended surgical treatment.
[0056] Treatment process: After being introduced to the outpatient clinic, the pain was relieved after three weeks of medication treatment, and the pain score dropped from 10 to 3 points. After two months of continued Chinese medicine treatment, the pain symptoms were significantly relieved, and normal life was restored. The mildly atrophied muscles were fully recovered. Conservative treatment was performed for one month every six months in the first 1-2 years. It has been more than 5 years and there is no obvious lumbar pain and discomfort. Daily activities are normal. No less than 10 people were introduced to come for treatment, and only one person underwent surgery, which was as effective as conservative treatment.
[0057] Typical application case 2:
[0058] Patient information: Niu, female, 43 years old.
[0059] Symptoms: Due to lumbar pain and discomfort, hospitalized, VAS score 6 points after admission, 2023 / 6 / 27 and magnetic examination showed that the lumbar physiological curvature existed, the lumbar sequence was neat, the posterior edge of the L3-4 and L4-5 intervertebral discs were bulging, the anterior dura mater sac at the corresponding level was compressed, the vertebral edge was rough, and the yellow ligament was not obviously thickened. There was no obvious abnormality in the morphological signal of the lower spinal cord and cauda equina.
[0060] Treatment process: After treatment with traditional Chinese medicine, the pain was relieved and the patient was discharged from the hospital with a VAS score of 2 points.
[0061] Example 2.
[0062] Prescription: Cimicifuga 9g, Bupleurum 9g, Millettia reticulata 15g, Lonicera japonica 15g, Atractylodes macrocephala 20g, White Peony 20g, Oyster 30g, Chicken Gizzard Stone 15g, Achyranthes bidentata 20g, Eucommia 15g, Cibotium barometz 12g, Rehmannia glutinosa 30g.
[0063] Preparation and use: Decoction in water to obtain 200 ml of juice, take in divided doses in the morning and evening.
[0064] application:
[0065] Typical application case 1:
[0066] Patient information: Mr. Guo, male, 61 years old, customs worker.
[0067] Symptoms: Lumbar pain and discomfort. MRI examination showed lumbar disc herniation. The pain and discomfort in the waist had a great impact on him, who was a photography enthusiast. He had to wear a waist belt for a long time.
[0068] Treatment process: After being introduced to Chinese medicine treatment, the symptoms improved significantly after one and a half months of treatment. After that, the treatment was consolidated for one month every six months. The waist belt is no longer used. It has been three years and the long-term effect is good.
[0069] Typical Application Case 2:
[0070] Patient Information: Sun XX, male, 73 years old.
[0071] Symptoms: Hospitalized due to low back pain discomfort, VAS score 4 points. MRI examination on October 4, 2021 showed: The cervical vertebrae were in regular alignment, the curvature was slightly straightened; Linear patchy fat-suppressed series long T2 signals were seen at the adjacent edges of cervical vertebrae 5 and 6; Hyperplasia was seen at the anterior and posterior edges of the remaining cervical vertebrae. The intervertebral discs showed low signals. The disc between cervical vertebrae 3 and 4 protruded posteriorly, secondarily compressing the right intervertebral foramen and causing it to narrow; The discs between cervical vertebrae 4 and 5, 5 and 6, and 6 and 7 bulged unevenly posteriorly, compressing the anterior edge of the dural sac at the corresponding levels, and the spinal canal diameter was not significantly narrowed, and no abnormal signals were seen in the cervical spinal cord. The lumbar physiological curvature existed, with hyperplasia and sharpness at the anterior and posterior edges of the vertebral bodies. The intervertebral disc signals were reduced, the intervertebral spaces were not significantly narrowed, and the discs between lumbar vertebrae 2 and 3, 3 and 4, 4 and 5, and between lumbar vertebra 5 and sacrum 1 bulged unevenly posteriorly, slightly compressing the anterior edge of the dural sac, and the ligamentum flavum was slightly thickened. The morphology and signals of the lumbar spinal cord were not significantly abnormal.
[0072] Treatment Process: After admission, the patient was treated with traditional Chinese medicine, and the pain was relieved by 2 points, then discharged.
[0073] Example 3.
[0074] Prescription: 5g of Cimicifuga foetida, 5g of Bupleurum chinense, 9g of Caulis Spatholobi, 9g of Caulis Lonicerae Japonicae, 15g of Atractylodes macrocephala, 15g of Paeonia lactiflora, 30g of Concha Ostreae, 15g of Endothelium Corneum Gigeriae Galli, 15g of Achyranthes bidentata, 9g of Eucommia ulmoides, 9g of Cibotium barometz, 20g of Rehmannia glutinosa.
[0075] Preparation and Administration: Decoct in water to obtain 200 ml of juice, and take it in divided doses morning and evening.
[0076] Application:
[0077] Typical Application Case 1:
[0078] Patient Information: Zhang XX, female, a teacher in a training institution.
[0079] Symptoms: Low back and leg pain discomfort, MRI examination showed lumbar degenerative disease, herniation of the disc between lumbar vertebrae 2 and 3, and herniation of the discs between lumbar vertebrae 3 and 4, 4 and 5, and between lumbar vertebra 5 and sacrum 1. Treated with acupuncture and extracorporeal shock wave for more than a month, with poor results. Could not sit for a long time, and could only walk less than 100 meters before needing to rest.
[0080] Treatment Process: Later, introduced by someone, the patient came to our department for treatment. After taking the medicine, the symptoms were significantly relieved after 2 weeks, the walking distance increased significantly, and could sit for a long time. After 2 months of consolidation treatment, the patient could take care of herself in daily life and had no obvious limitation in walking.
[0081] Typical Application Case 2:
[0082] Patient Information: Wang XX, male, 51 years old.
[0083] Symptoms: Admitted to the hospital in February 2023 due to low back pain discomfort. The VAS score was 6 points at the time of admission. Examination equipment: Siemens 1.5T MR, examination number: M132957, examination time: 2023 / 2 / 21. It was indicated that the physiological curvature of the lumbar spine was straightened, the lumbar spine sequence was regular, the posterior edges of the L4-L5 and L5-S1 intervertebral discs bulged, the anterior epidural sac was compressed at the corresponding level, the edges of the vertebral bodies were rough, and the ligamentum flavum was not significantly thickened. The morphology and signal of the lower segment of the spinal cord and cauda equina were not significantly abnormal.
[0084] Treatment process: After drug treatment, the pain score was 4 points, and the patient was discharged after remission.
[0085] Example 4.
[0086] Prescription: 5g of Cimicifuga foetida, 5g of Bupleurum chinense, 12g of Spatholobus suberectus, 12g of Lonicera japonica, 15g of Atractylodes macrocephala, 15g of Paeonia lactiflora, 20g of Oyster, 12g of Endothelium corneum gigeriae galli, 15g of Achyranthes bidentata, 12g of Eucommia ulmoides, 12g of Cibotium barometz, 20g of Rehmannia glutinosa.
[0087] Preparation and administration: Decoct in water to obtain 200 ml of juice, take it in divided doses morning and evening for at least 4 weeks.
[0088] Application:
[0089] Typical application case 1:
[0090] Patient information: A certain American, 53 years old, female.
[0091] Symptoms: In April 2023, due to low back pain discomfort and neck discomfort, the patient was hospitalized for treatment. Magnetic resonance imaging (MRI) examination at admission showed that the cervical curvature was present, the sequence was regular, no obvious abnormal signal was seen in the vertebral bodies, and the edges of the vertebral bodies were slightly rough and pointed; the signals of each cervical intervertebral disc decreased in the T2WI sequence, there was no obvious bulge or herniation of the intervertebral discs, the anteroposterior diameter of the spinal canal was not significantly reduced, and no obvious abnormal signal was seen in the cervical spinal canal. The lumbar curvature was normal, the sequence was regular, the edges of the vertebral bodies were slightly rough and pointed, the intervertebral spaces were not significantly narrowed; the signals of each lumbar intervertebral disc decreased in the T2VI sequence, the L4-L5 and L5-S1 intervertebral discs bulged slightly backward, the anterior edge of the epidural sac was slightly compressed, the local spinal canal was slightly narrowed, and no obvious abnormal signal was seen in the lumbar spinal canal.
[0092] Treatment process: Admitted to the hospital for treatment due to low back pain discomfort, discharged after 11 days of improvement, and currently working normally.
[0093] Typical application case 2:
[0094] Patient information: A certain Yu, male.
[0095] Symptoms: Hospitalization number: 504253, hospitalized due to low back pain accompanied by sciatica, with severe pain, VAS score of 10 points. MRI on September 22, 2022 showed: The physiological curvature of the cervical spine was straightened, the vertebral body sequence was continuous, the [structure] was significantly thickened, and no obvious abnormal signal was seen in the morphology of the cervical spinal cord. The anterior and posterior edges of the bones of each vertebral body were hyperplastic and pointed. The signals of multiple intervertebral discs were reduced on T2, the intervertebral space was slightly narrowed, and the discs at C3-C4, C4-C5, and C5-C6 protruded slightly backward, compressing the anterior edge of the dural sac at the corresponding level. The diameter of the spinal canal was not significantly narrowed, and the ligamentum flavum was not obvious. The physiological curvature of the lumbar spine was present, the vertebral body sequence was continuous, the signal was normal, and the edges of some vertebral bodies were hyperplastic and pointed. The T2 sequence showed uneven reduction of the signals of multiple intervertebral discs. The discs at L4-L5 and L5-S1 protruded backward, compressing the anterior side of the dural sac at the corresponding level. The ligamentum flavum was not significantly thickened, and the diameter of the spinal canal was not significantly narrowed.
[0096] Treatment process: After admission, traditional Chinese medicine treatment was given. When discharged, the pain score was 9 points. After discharge, outpatient follow-up with traditional Chinese medicine treatment for more than one month, and the pain was significantly relieved. Able to take care of oneself.
[0097] Example 5.
[0098] Prescription: 5g of Cimicifuga foetida, 5g of Bupleurum chinense, 9g of Spatholobus suberectus, 9g of Lonicera japonica Thunb., 15g of Atractylodes macrocephala, 15g of Paeonia lactiflora, 25g of Oyster, 9g of Endothelium corneum gigeriae galli, 15g of Achyranthes bidentata, 9g of Eucommia ulmoides, 9g of Cibotium barometz, 25g of Rehmannia glutinosa.
[0099] Preparation and administration: Decoct with water to obtain 200 ml of juice, take it in divided doses morning and evening, and take it for at least 4 weeks.
[0100] Application:
[0101] Typical application case 1:
[0102] Patient information: Li XX, 91 years old, male.
[0103] Symptoms: Admitted to the hospital for treatment on May 28, 2022 due to symptoms such as low back pain discomfort. MRI examination showed: The curvature of the cervical spine was straightened, the sequence was irregular, the C4 vertebral body was slightly displaced forward, the C5 and C6 vertebral bodies were displaced backward, the edges of the vertebral bodies were hyperplastic and pointed, some intervertebral spaces were narrowed, a slightly long T1 and slightly long T2 signal focus with a long diameter of about 4 mm was seen in the C6 vertebral body, high signal in the fat-suppression series, the signals of each intervertebral disc were reduced in the T2M1 sequence, and the discs at C2-C3, C3-C4, C4-C5, and C5-C6 bulged around and protruded backward, compressing the anterior edge of the dural sac, and the anteroposterior diameter of the local spinal canal was slightly narrowed. No obvious abnormal signal was seen in the cervical spinal canal.
[0104] The curvature of the lumbar spine was straightened, the sequence was regular, the edges of the vertebral bodies were rough and pointed, and the intervertebral space was not significantly narrowed. The signals of each lumbar intervertebral disc were reduced in the 120 sequence. The discs at L3-L4, L4-L5, and L5-S1 bulged around, slightly compressing the anterior edge of the dural sac, and the local spinal canal was slightly narrowed. No obvious abnormal signal was seen in the lumbar spinal canal.
[0105] Treatment process: After admission and treatment, the patient was discharged on June 5th after pain relief.
[0106] Typical application case 2:
[0107] Patient information: Li XX, hospital number: 532420, male, 60 years old.
[0108] Symptoms: Hospitalized due to lumbar discomfort. On May 20, 2023, the MRI diagnosis report showed that the cervical vertebrae were neatly arranged and the curvature was slightly straightened; the vertebral morphology was slightly hyperplastic and pointed. The intervertebral disc showed a low signal, and the cervical 3-4, 4-5, 5-6, and 6-7 intervertebral discs protruded backwards, and the anterior edge of the dura mater sac at the corresponding level was compressed. There was no obvious stenosis of the spinal canal diameter, and no abnormal signal was found in the cervical cord. The physiological curvature of the lumbar spine existed, and a linear long T2 signal was seen at the lower edge of the lumbar 2 vertebra; the edges of the remaining vertebrae were slightly pointed. The intervertebral disc signal was acceptable, and some signals were slightly reduced. There was no obvious narrowing of the intervertebral space. The lumbar 3-4 and 4-5 intervertebral discs bulged unevenly toward the posterior edge, and the anterior edge of the dura mater sac was compressed. There was no obvious abnormality in the morphology and signal of the lumbar cord.
[0109] Treatment process: After admission and treatment, the symptoms were relieved and the patient was discharged.
[0110] We conducted a retrospective study on the clinical application of Tiaoqi Zhitong Decoction, retrieved the archived medical records of inpatients who were diagnosed with lumbar disc herniation as the first diagnosis and treated with Tiaoqi Zhitong Decoction from January 2012 to June 2022 in the Fifth Affiliated Hospital of Xinjiang Medical University, and used SPSS21.0 statistical software to statistically analyze the results, and used rank sum test and chi-square test to test the results. The effect of the Chinese medicine composition of the present invention, i.e., Tiaoqi Zhitong Decoction, in the treatment of lumbar disc herniation and the distribution law of related syndrome types were explored.
[0111] The results showed that 1244 cases of LDH were treated with the Chinese medicine composition decoction of the present invention, namely, the Tiaoqi Zhitong Decoction, and all were discharged from the hospital with improvement. The following results were obtained by studying the syndrome type, age, gender, onset time and other related issues in the treatment.
[0112] (1) Syndrome composition of patients who used Tiaoqi Zhitong Decoction during hospitalization
[0113] The syndrome types in the past medical records are relatively scattered, so "liver and kidney yin deficiency", "liver and kidney deficiency with phlegm and dampness blocking the collaterals", "liver and kidney yin deficiency, blood stasis blocking the collaterals", "liver and kidney deficiency, qi stagnation and blood stasis", "liver and kidney yin deficiency, qi stagnation and blood stasis" can be classified as "liver and kidney yin deficiency and combined syndromes".
[0114] The results are as follows Figure 1 It can be seen that the Chinese medicine composition decoction of the present invention is applied to liver-kidney yin deficiency and its associated syndromes with a maximum composition ratio of 38.1%, followed by qi stagnation and blood stasis syndrome with 36.1%, and the composition ratio is the least for dampness syndrome and other associated syndromes.
[0115] (2) Gender ratio of patients
[0116] Analysis of the gender composition of 1244 LDH patients treated with the Qi-Regulating and Pain-Relieving Decoction found that there were 481 male patients, with a composition ratio of approximately 39.1%; there were 763 female patients, with a composition ratio of approximately 62.0%. The number of female patients was higher than that of male patients, as shown in Figure 2 .
[0117] (3) Age distribution of patients
[0118] ① Local distribution
[0119] Research on the local distribution of gender-age related patients among 1244 LDH patients treated with the Qi-Regulating and Pain-Relieving Decoction found that the largest number of male and female patients was concentrated between 50 and 60 years old, the smallest number was under 25 years old, and the number of male patients was generally higher than that of female patients before the age of 40; after the age of 40, the number of female patients was generally higher than that of male patients, as shown in Figure 3 .
[0120] ② Overall composition ratio
[0121] Analysis of the overall composition ratio of gender-age related 1244 LDH patients treated with the Qi-Regulating and Pain-Relieving Decoction showed that the composition ratio of patients in the 50-60 age group was relatively large, accounting for 36.2%, followed by the 60-70 age group, accounting for 19.0%, as shown in Table 1
[0122] Table 1 Gender and age segment composition of 1244 LDH patients treated with the Qi-Regulating and Pain-Relieving Decoction (%)
[0123]
[0124] Comparing the gender and age composition, after chi-square test, the difference was statistically significant
[0125] As described above, it is only the preferred embodiment of the embodiments of the present invention, and does not impose any form of limitation on the embodiments of the present invention. Any simple modification, equivalent change and modification made to the above embodiments based on the technical essence of the embodiments of the present invention still fall within the scope of the technical solutions of the embodiments of the present invention
Claims
1. A traditional Chinese medicine composition for treating pain and discomfort caused by cervical and lumbar disc herniation, characterized in that, It is made from the following raw materials in parts by weight: Cimicifugae Rhizoma 5 - 9 parts, Bupleuri Radix 5 - 9 parts, Spatholobi Caulis 9 - 15 parts, Lonicerae Japonicae Caulis 9 - 15 parts, Atractylodis Macrocephalae Rhizoma 12 - 20 parts, Paeoniae Radix Alba 12 - 20 parts, Ostreae Concha 20 - 30 parts, Galli Gigeriae Endothelium Corneum 9 - 15 parts, Achyranthis Bidentatae Radix 15 - 20 parts, Eucommiae Cortex 9 - 15 parts, Cibotii Rhizoma 9 - 12 parts, Rehmanniae Radix Preparata 20 - 30 parts.
2. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition is made from the following raw materials in parts by weight: Cimicifugae Rhizoma 5 parts, Bupleuri Radix 5 parts, Spatholobi Caulis 9 - 12 parts, Lonicerae Japonicae Caulis 9 - 12 parts, Atractylodis Macrocephalae Rhizoma 12 - 20 parts, Paeoniae Radix Alba 12 - 20 parts, Ostreae Concha 20 - 30 parts, Galli Gigeriae Endothelium Corneum 9 - 12 parts, Achyranthis Bidentatae Radix 15 parts, Eucommiae Cortex 9 - 12 parts, Cibotii Rhizoma 9 - 12 parts, Rehmanniae Radix Preparata 20 - 30 parts.
3. The traditional Chinese medicine composition according to claim 2, characterized in that, The traditional Chinese medicine composition is made from the following raw materials in parts by weight: Cimicifugae Rhizoma 5 parts, Bupleuri Radix 5 parts, Spatholobi Caulis 9 parts, Lonicerae Japonicae Caulis 9 parts, Atractylodis Macrocephalae Rhizoma 15 parts, Paeoniae Radix Alba 15 parts, Ostreae Concha 20 parts, Galli Gigeriae Endothelium Corneum 9 parts, Achyranthis Bidentatae Radix 15 parts, Eucommiae Cortex 9 parts, Cibotii Rhizoma 9 parts, Rehmanniae Radix Preparata 20 parts.
4. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition is the traditional Chinese medicine composition in decoction form.
Citation Information
Patent Citations
Chinese proprietary for treating protrusion of lumber interverterbral disc and its prepn.
CN1375308A