A pH detection device for digestive tract capsule

Abstract

The present invention discloses a digestive tract capsule pH detection device, including a capsule detector; a magnetic drive mechanism for driving and controlling the capsule detector; the magnetic drive mechanism includes a magnetic airbag, the magnetic airbag includes an airbag bag, and the inner circle of the airbag bag is provided with a pleated structure; a plurality of inner bags are provided in the inner cavity of the airbag bag; the other end of each inner bag is connected to the outer bag; the inner and outer bags are filled with magnetic slurry; the airbag bag is provided with an inflation hole, which is connected to the air pump through an inflation pipeline; an electromagnet rod is also provided inside the outer bag. The present invention also discloses a method for preparing magnetic slurry and magnetic fluid. The present invention does not rely on different pH values ​​of the digestive tract to locate the position, but uses the magnetic force generated by the magnetic drive mechanism to drive the movement and positioning of the capsule detector, and is equally applicable regardless of whether the pH value of the patient's digestive tract is normal. Similarly, for critically ill patients, the positioning and excretion problems of the capsule detector in the intestine can be solved.

Description

Technical Field

[0001] The present application belongs to the field of medical detection technology, and designs a pH detection device for the digestive system, specifically a magnetic driving mechanism for a digestive tract capsule pH detection device and a method for preparing the magnetic slurry and magnetic fluid thereof. Background Art

[0002] Monitoring the pH value of the digestive tract is of great value for the treatment effect of mucosal status, bacterial colonization, intestinal nutrient absorption, and enteral drug administration.

[0003] The number of capsule medical devices for the digestive tract is increasing day by day: "Capsule endoscopy" is the full name of "intelligent capsule digestive tract endoscopy system", which can be used to collect images of the surface features of the digestive tract; "remote control release capsule" can complete the targeted drug delivery in the digestive tract; there are also capsules that can take samples in the digestive tract; the "Smart Pill" developed by the American Diagnostics Company is specifically used to detect the pressure, pH value and other indicators inside the digestive tract. These data are very important for the diagnosis of gastrointestinal motility diseases such as "gastroesophageal reflux disease". Smart pill contains a pH detector and a pressure sensor device, and the pH detector is used to locate the position of the capsule according to the different pH values ​​of the digestive tract. Therefore, it is only suitable for patients with normal digestive tract pH values ​​to detect whether there are abnormalities in digestive tract motility. For long-term bedridden patients and patients with intestinal pH disorders, the problem of positioning and excretion of capsules in the body is still unsolved.

[0004] For this problem, an invention patent "A multifunctional capsule endoscope system suitable for the digestive tract" disclosed in the authorization announcement number CN103356154B of the Second Military Medical University of the Chinese People's Liberation Army can solve it; however, in actual use, after the subject takes the capsule, he lies on the medical electric bed, and the doctor's console controls the five-dimensional motion platform and the magnetic head. The magnetic field generated by the magnetic head controls the magnet in the capsule, thereby manipulating the capsule in the body to any position in the digestive tract for observation. At the same time, according to whether the actual detection is needed, the pH sensor is turned on to detect the pH value at this position. When the doctor determines that the pH detection capsule needs to stay at a certain position for timed pH value detection, the subject can be given a vest or belt, and the position and number of magnets in the vest or belt can be adjusted according to the observed part, so that the magnetic field generated by the portable magnet array of the vest or belt can achieve the best distribution. This magnetic field distribution should be able to maintain the position of the detection capsule in the body for a specific time, thereby realizing timed pH value detection of specific parts in the digestive tract. Research on the above technology found that since it only relies on the five-dimensional motion platform and the magnetic head to drive the capsule to move in the digestive tract through magnetic force, the magnetic head's control of the capsule's motion trajectory is not precise enough, especially the motion control in the intestine is very limited. In addition, there is a certain distance between the magnetic head and the patient, and the magnetic head's motion trajectory and flexibility are limited. On the one hand, the magnetic head must generate a very large magnetic field to drive the capsule to move. Once the operation is wrong, it may cause the capsule to squeeze and impact the intestine in an instant, which may cause very serious discomfort or even pain to the patient; finally, the position and number of magnets placed in the vest or belt must be adjusted according to the observed part to locate the capsule in the human body. The adjustment process is very dependent on experience and takes a long time. Once the capsule is displaced during the adjustment process, it is necessary to re-correct the position, and the magnets placed in the vest or belt must be removed and started all over again, which is time-consuming and labor-intensive, and the experience is poor. Summary of the invention

[0005] In view of the defects existing in the prior art, the present invention proposes a new digestive tract capsule pH value detection device, comprising a capsule detector; a magnetic drive mechanism for driving and controlling the capsule detector; the magnetic drive mechanism comprises a magnetic airbag, the magnetic airbag comprises an airbag bag, the inner circle of the airbag bag is provided with a pleated structure; a plurality of inner bags are provided in the inner cavity of the airbag bag; one end of each of the inner bags is connected to the inner wall of the airbag bag close to the pleated structure, and the other end of each of the inner bags is connected to the outer bag; the interiors of the inner bags and the outer bags are both filled with magnetic slurry; an inflation hole is provided on the airbag bag, and the inflation hole is connected to an air pump through an inflation pipeline; an electromagnet rod is also provided inside the outer bag.

[0006] Preferably, the magnetic airbag is a circular ring structure, and a lifting plate is correspondingly arranged below the inner ring of the magnetic airbag. Preferably, the inner bag is a semi-ellipsoidal structure, the long axis direction of the inner bag is arranged along the radial direction of the airbag, one end of the inner bag in the short axis direction is connected to the inner wall of the airbag close to the pleated structure; the other end of the inner bag in the short axis direction is connected to the outer bag; the outer bag is a rugby ball-shaped structure, and the long axis direction of the outer bag is coaxial with the long axis direction of the inner bag.

[0007] Preferably, the volume ratio of the outer bag to the inner bag is 3-3.5:1.

[0008] Preferably, a vibrating ball is further provided at the connection point between two adjacent inner bags and the outer bag, and the vibrating ball is fixedly connected to the inner wall of the airbag bag.

[0009] Preferably, a magnetic compensation ring is provided on the outer side of the magnetic airbag; the outer ring of the airbag bag is sealed and connected to the inner ring of the magnetic compensation ring; the magnetic compensation ring includes a shell, an iron medium is arranged in the shell, a magnetic fluid containing cavity is formed between the outer wall of the iron medium and the inner wall of the shell, and the magnetic fluid containing cavity is filled with magnetic fluid; an electromagnet block is arranged inside the iron medium.

[0010] Further preferably, the cross section of the iron medium is triangular.

[0011] Further preferably, the cross section of the ferroic medium is a right triangle, and two right-angled sides corresponding to the ferroic medium are in contact and connected with the inner wall of the shell.

[0012] Further preferably, a protrusion is provided on the oblique edge corresponding to the ferroic medium, and the protrusion and the inner wall of the shell form a magnetic fluid containing cavity.

[0013] Further preferably, the cross section of the raised portion is arc-shaped.

[0014] Further preferably, a drain valve is provided at the upper end of the shell, and the drain valve is connected to the magnetic fluid containing chamber; a magnetic fluid input valve and a magnetic fluid output valve are provided at the lower end of the shell, and the magnetic fluid input valve and the magnetic fluid output valve are both connected to the magnetic fluid containing chamber, and the magnetic fluid input valve and the magnetic fluid output valve are both externally connected to a peristaltic pump.

[0015] The invention also provides a method for preparing magnetic slurry, which comprises ball-milling manganese zinc ferrite, chitosan quaternary ammonium salt, butyl hydroxybenzoate and water, and defoaming after ball-milling to prepare magnetic slurry.

[0016] Further preferably, the rotation direction of the ball mill remains unchanged during ball milling.

[0017] More preferably, vacuum defoaming is used to perform defoaming, and magnetic slurry is obtained after defoaming.

[0018] Further preferably, the manganese zinc ferrite is in powder form, with a powder particle size D50=1.2 μm and a specific surface area of ​​13.6 m 2 / g.

[0019] The invention also provides a method for preparing a magnetic fluid, comprising ball-milling carbonyl iron oxide, diacetone acrylamide, glycerol and water, and defoaming the mixture after the ball-milling to prepare the magnetic fluid.

[0020] Further preferably, the rotation direction of the ball mill remains unchanged during ball milling.

[0021] More preferably, vacuum defoaming is used to perform defoaming, and magnetic slurry is obtained after defoaming.

[0022] More preferably, the carbonyl iron oxide is in powder form, with a powder particle size D50=0.8 μm and a specific surface area of ​​32.2 m 2 / g. Compared with the prior art, the present invention has the following beneficial effects:

[0023] 1. The digestive tract capsule pH detection device provided by the present invention, the capsule detector enters from the mouth and is discharged from the rectum, or is input into the capsule detector through a gastroscope and discharged from the rectum, and the entire detection process can be achieved by a magnetic drive mechanism. The capsule detector has a pH sensor, which can measure the pH value at different positions in the digestive tract under magnetic drive. The detection device of this application can also be considered to be combined with UWB positioning technology in the future.

[0024] 2. The present invention relies on external magnetic force to solve the problem of the capsule detector's forward power, and finally the capsule detector can be discharged very smoothly from the rectum. It does not rely on different pH values ​​of the digestive tract to locate the position, and is equally applicable regardless of whether the pH value of the patient's digestive tract is normal. Similarly, for critically ill patients, the problem of positioning and discharge of the capsule detector in the intestine can be solved.

[0025] 3. The annular magnetic airbag of the present invention can be adjusted according to the patient's body shape, so that the magnetic force regulation of the magnetic drive mechanism used to drive or control the capsule detector remotely is more effective and flexible, with good magnetic force regulation effect and good versatility. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a schematic diagram of the structure of the capsule detector of the present invention.

[0027] Figure 2 It is a structural schematic diagram of the magnetic drive mechanism of the present invention.

[0028] Figure 3It is a schematic structural diagram of the magnetic compensation ring of the present invention.

[0029] Figure 4 It is a schematic diagram of the structure of the magnetic airbag of the present invention. DETAILED DESCRIPTION

[0030] Example 1 See Figure 1 The magnetic driving mechanism of this embodiment is used in conjunction with the digestive tract capsule pH detection device.

[0031] The digestive tract capsule pH detection device includes a capsule detector, which includes a capsule shell 10. A transparent end 11 is provided at one end of the capsule shell 10. An image acquisition unit 14, a pH sensor 13 and a permanent magnet 12 are provided inside the capsule shell 10. The image acquisition unit 14 is opposite to the transparent end 11; the permanent magnet 12 is a spherical structure.

[0032] Although this embodiment describes the relevant content of the digestive tract capsule pH detection device, it also belongs to the prior art. The specific principles, structure and use can refer to and directly use the contents disclosed in the patent document "A multifunctional capsule endoscope system suitable for the digestive tract" (patent announcement number: CN103356154B).

[0033] See also Figure 2 and Figure 4 This embodiment mainly discloses a magnetic driving mechanism for a digestive tract capsule pH detection device. The magnetic driving mechanism includes a circular magnetic airbag 30 and a magnetic compensation ring 20 sleeved on the outside of the magnetic airbag 30.

[0034] The magnetic airbag 30 includes a circular airbag bag 31, the outer ring of the airbag bag 31 is sealed and connected to the inner ring of the shell 21, the inner ring of the airbag bag 31 is provided with a pleated structure 34, and the inner cavity of the airbag bag 31 is provided with a plurality of inner bags 33, the inner bags 33 are semi-ellipsoidal structures, the long axis direction of the inner bags 33 is arranged along the radial direction of the airbag bag 31, one end of the short axis direction of the inner bag 33 is connected to the inner wall of the airbag bag 31 close to the pleated structure as a whole, and the inner cavity of the airbag bag 31 is also provided with an outer bag connected to the inner bag 33 35, the other end of the inner bag 33 in the short axis direction is connected with the outer bag 35; the outer bag 35 is a rugby ball-shaped structure, and the long axis direction of the outer bag 35 is coaxial with the long axis direction of the inner bag 33; the interiors of the inner bag 33 and the outer bag 35 are both filled with magnetic slurry, and an electromagnet rod is also installed in the outer bag 35, and an inflation hole is provided on the air bag 31, and the inflation hole is connected with the air pump through an inflation pipeline, and the gas is filled in the air cavity 32, and the air cavity 32 is located between the outer walls of the inner bag 33 and the outer bag 35 and the inner wall of the air bag 35.

[0035] In this embodiment, the semi-ellipsoidal structure refers to a structure obtained by cutting an ellipsoid along the direction of its major axis or minor axis. In this embodiment, the inner capsule 33 is a semi-ellipsoidal structure obtained by cutting an ellipsoid along the direction of its minor axis.

[0036] In this embodiment, the magnetic field generated by the magnetic driving mechanism can generate magnetic force on the permanent magnet 12 in the capsule detector, thereby remotely driving or controlling the capsule detector to move or stay at a specific position.

[0037] When in use, a lifting plate 40 is correspondingly provided below the hollow in the center of the magnetic airbag 30. The patient stands on the electric lifting plate 40, and the electric lifting plate 40 is used to lift and lower the patient, thereby controlling the magnetic airbag 30 to be located at the patient's waist and abdomen, mainly flush with the patient's stomach. After the patient takes the capsule detector and the capsule detector enters the patient's stomach, the airbag bag 31 is inflated and pressurized, and the airbag bag 31 will gradually swell from being deflated. Since the outer periphery of the airbag bag 31 is restricted by the magnetic compensation ring 20, the inner circle of the airbag bag 31 has a pleated structure 34, which can expand or be squeezed and tightened by the airbag bag 31 during the inflation process, so that the inner circle of the airbag bag 31 can finally be close to the patient's chest and abdomen, thereby minimizing the distance between the outer bag 35, the inner bag 33 and the permanent magnet 12 in the capsule detector. Since the magnetic slurry in the outer bag 35 and the inner bag 33 becomes an electromagnet and generates magnetic force after the electromagnet rod is energized, it can exert an attractive or repulsive magnetic force on the permanent magnet 12 in the capsule detector. The outer bag 35 and the inner bag 33 are symmetrically distributed around the patient and can be arranged into 18 groups, 36 groups, 72 groups, etc., so as to more conveniently and flexibly control the permanent magnet 12 in the capsule detector, thereby adjusting the movement trajectory of the capsule detector. Because there needs to be a gap between two adjacent outer bags 35 (or inner bags 33), there is also a blank area. In addition, the air bag 31 will also be deformed when it is inflated, and a part of the outer bag 35 and the inner bag 33 may be twisted or deformed, so it is necessary to use a magnetic compensation ring 20 to compensate for the magnetic field.

[0038] Embodiment 2

[0039] This embodiment is a preferred solution of embodiment 1, see Figure 4 In the airbag bag 31, the volume ratio of the outer bag 35 to the inner bag 33 is 3.3:1. Such a volume ratio makes it easier to deform and retract inward, thereby clamping the patient, thereby shortening the distance between the inner bag 33 and the patient. Because the magnetic slurry in the inner bag 33 must have a large enough area to align with the patient, the minor axis of the ellipse must be aligned with the patient.

[0040] Since the magnetic slurry is similar to the shape of "toothpaste", if it is not in the shape of "toothpaste", a large amount of magnetic slurry may flow back from the inner bag 33 into the outer bag 35, and the inner bag 33 cannot have a stable and sufficient amount of magnetic slurry. In the present invention, due to the special structure of the inner bag 33 and the outer bag 35, the magnetic slurry in the outer bag 35 is easy to enter the inner bag 33 when it is squeezed by an external force (the squeezing force on the upper and lower sides of the outer bag 35), and when the inner bag 33 is squeezed by a force perpendicular to the surface where the minor axis of the ellipse is located, the magnetic slurry in the inner bag 33 is not easy to flow back into the outer bag 35. The specific test is:

[0041] If the outer bag 35 is ellipsoidal, rather than rugby-shaped, a weight is directly used to press the upper side of the outer bag 35; it is found that under the same pressure of 500g, the magnetic slurry in the rugby-shaped outer bag 35 is easier to squeeze into the inner bag 33, and the weight of the magnetic slurry squeezed into the inner bag 33 will increase by 32%. If the outer bag 35 is spherical, it is found that under the same pressure of 500g, the magnetic slurry in the rugby-shaped outer bag 35 is easier to squeeze into the inner bag 33, and the weight of the magnetic slurry squeezed into the inner bag 33 will increase by 71%.

[0042] If the inner bag 33 is hemispherical (obtained by cutting along the diameter of a sphere), use a cylinder to perform vertical extrusion on the surface where the diameter of the inner bag 33 is located, and the extrusion pressure of the cylinder is 0.1 bar. The inner bag 33 is filled with magnetic slurry, and there is no magnetic slurry in the outer bag 35; after extrusion, cut it along the connecting port, and measure the weight of the magnetic slurry squeezed into the outer bag 35. It is found that under the same extrusion pressure, compared with the hemispherical shape, the magnetic slurry in the semi-elliptical inner bag 33 is less likely to be squeezed into the outer bag 35, and the weight of the magnetic slurry squeezed into the outer bag 35 will be 53% less. Similarly, compared with the semi-rugby shape (obtained by cutting along the short axis direction of the rugby), the magnetic slurry in the semi-ellipsoidal inner bag 33 is less likely to be squeezed into the outer bag 35, and the weight of the magnetic slurry squeezed into the outer bag 35 will be 37% less.

[0043] If the volume of the outer bag 35 is too large, such as the ratio of the volume of the outer bag 35 to the inner bag 33 is 5:1, the air bag 31 will be slightly deformed, causing the magnetic slurry in many outer bags 35 to fill multiple inner bags 33; if the volume of the outer bag 35 is too small, such as the ratio of the volume of the outer bag 35 to the inner bag 33 is 1:1, the air bag 31 needs to be deformed more to fill the magnetic slurry in the outer bag 35 corresponding to the squeezed deformation into the corresponding inner bag 33. Both situations are not suitable for actual use.

[0044] Embodiment 3

[0045] This embodiment is a preferred solution of embodiment 1, see Figure 4Due to the large deformation degree of the outer bag 35 and the inner bag 33 for some patients who are too thin, in order to ensure the continuous and uniform distribution of the magnetic slurry therein, the connecting point between the outer bag 35 and the inner bag 33 is a connecting port, and a vibrating ball 36 is also provided at the two adjacent connecting ports, and the vibrating ball 36 is fixedly connected to the inner wall of the airbag bag 31.

[0046] The vibrating ball 36 will generate a small amplitude vibration when powered on, so that the magnetic slurry vibration in the outer bag 35 and the inner bag 33 nearby can be distributed more evenly, effectively maintaining continuity.

[0047] Embodiment 4

[0048] This embodiment is a preferred solution of embodiment 1, see Figure 2 and Figure 3 The magnetic compensation ring 20 includes a circular ring-shaped shell 21, and a circular ring-shaped ferroelectric medium 22 is arranged inside the shell 21. In this embodiment, the cross-section of the ferroelectric medium 22 is a right triangle and the two right-angled sides of the right triangle are in contact with and fixedly connected to the inner wall of the shell 21. A protrusion 221 is arranged at the hypotenuse of the ferroelectric medium 22. The cross-section of the outer periphery of the protrusion 221 is an arc. A gap is arranged between the upper end of the protrusion 221 and the upper end of the shell 21, and a gap is arranged between the lower end of the protrusion 221 and the inner ring of the shell 21. The inner ring of the shell 21 is made of ferromagnetic material, and the rest of the shell 21 can be made of non-magnetic material; a magnetic fluid containing chamber 23 is arranged inside the shell 21, and the magnetic fluid containing chamber 23 is filled with magnetic fluid, and an electromagnet block is embedded in the ferroelectric medium 22.

[0049] When used specifically, Figure 3 As shown, the inner circle of the airbag bag 31 is squeezed and restrained at the patient's waist and abdomen, and the electric lifting plate 40 moves downward, so that the airbag bag 31 is pulled into a basin shape, covering the entire abdomen, and the experience is better than direct squeezing and covering. At this time, the outer bag 35 and the inner bag 33 are no longer in the same plane with the magnetic compensation ring 20. The magnetic compensation ring 20 can quantitatively input or output magnetic fluid into the magnetic fluid containing chamber 23 through a peristaltic pump, thereby accurately controlling the amount of magnetic fluid in the magnetic fluid containing chamber 23. Through the height of the magnetic fluid in the magnetic fluid containing chamber 23, and the size and magnetic polarity of the magnetic force generated by the electromagnet block in the iron medium 22, during the actual adjustment process, the magnetic field generated in the magnetic fluid containing chamber 23 will generate corresponding magnetic force on the capsule detector. If there is a blind spot in the control of the capsule detector by the magnetic airbag 30, the magnetic field generated in the magnetic fluid containing chamber 23 can not only make the capsule detector stay at a certain position in the digestive tract, but also drive the capsule detector downward or upward, but the control accuracy is not as good as the magnetic airbag 30; the magnetic compensation ring 20 serves as an auxiliary compensation for the magnetic airbag 30, and the two can be used in combination to achieve better control effect and eliminate the control blind spot of the magnetic airbag 30.

[0050] Doctors can test and adjust the capsule detector by testing the magnetic airbag 30 in the patient's stomach to see whether it can reach the range of 0-360° (along the circumferential direction of the magnetic compensation ring 20) with an adjustment accuracy of 1°, 2°, 5°, 10°, etc., so as to facilitate the subsequent selection of whether to start the magnetic compensation ring 20 for further compensation adjustment. The magnetic slurry in the outer bag 35 and the inner bag 33 is similar to a "magnetic needle" after magnetization, and its axis can be horizontal, and is usually inclined in the later stage (the degree of inclination can be adjusted by adjusting the lifting height of the electric lifting plate 40, the degree of inflation in the airbag 31, etc.). Therefore, the movement trajectory of the capsule detector can be accurately controlled by controlling the magnetic force of the "magnetic needle" in different directions.

[0051] The arrangement of the raised portion 221 allows the volume of the magnetic fluid to change more when the liquid level of the magnetic fluid changes by the same amplitude. If the raised portion 221 is not provided, the volume of the magnetic fluid to change less when the liquid level of the magnetic fluid changes by the same amplitude. In addition, the arrangement of the cambered surface allows the magnetic fluid to flow more easily into the magnetic fluid containing chamber 23.

[0052] Embodiment 5

[0053] This embodiment is a preferred solution of the fourth embodiment. To facilitate exhaust, an exhaust valve 25 is provided at the upper end of the housing 21, and the exhaust valve 25 is connected to the magnetic fluid receiving chamber 23. A magnetic fluid input valve 24 and a magnetic fluid output valve 26 are provided at the lower end of the housing 21, and both the magnetic fluid input valve 24 and the magnetic fluid output valve 26 are connected to the magnetic fluid receiving chamber 23. Both the magnetic fluid input valve 24 and the magnetic fluid output valve 26 are externally connected to a peristaltic pump. The peristaltic pump can quantitatively transport magnetic fluid into the magnetic fluid receiving chamber 23 or pump magnetic fluid out of the magnetic fluid receiving chamber 23, thereby conveniently controlling the amount of magnetic fluid in the magnetic fluid receiving chamber 23.

[0054] Embodiment 6

[0055] This embodiment is a preferred embodiment of the first embodiment, and specifically discloses a method for preparing magnetic slurry, comprising the following steps: 2000g of manganese zinc ferrite, 690g of chitosan quaternary ammonium salt, 130g of butyl hydroxybenzoate, and 1160g of water are ball-milled in a ball mill, the rotation direction of the ball mill remains unchanged during the ball milling, the ball milling is performed for 12 hours, and the defoaming is performed by vacuum defoaming, and the magnetic slurry is obtained after the defoaming is completed. The manganese zinc ferrite is in powder form, the powder particle size D50=1.2μm, and the specific surface area is 13.6m 2 / g.

[0056] The magnetic slurry prepared as above can generate magnetic force as a whole after being magnetized, and it also has properties similar to "toothpaste".

[0057] The magnetic slurry was tested using a laboratory 150ml short-necked triangular funnel. 150ml of magnetic slurry was poured into the short-necked triangular funnel. After 30 minutes of observation, it was found that the magnetic slurry could not leak out of the short-necked triangular funnel. However, if a 500g weight was placed on the surface of the magnetic slurry in the short-necked triangular funnel, 63ml would flow out within 3 minutes.

[0058] Comparative Example 1

[0059] The amount of butyl hydroxybenzoate in this example is reduced to 20 g, and the rest is replaced by methylisothiazolinone, that is, the formula is: 2000 g manganese zinc ferrite, 690 g chitosan quaternary ammonium salt, 20 g butyl hydroxybenzoate, 110 g methylisothiazolinone, 1160 g water. The rest remains unchanged, and the final slurry 1 is prepared.

[0060] The magnetic properties of slurry 1 after magnetization are the same as those of the magnetic slurry prepared in this embodiment. A 150ml short-necked triangular funnel in the laboratory is used for testing. 150ml of slurry 1 is poured into the short-necked triangular funnel. After 10 minutes of observation, it is found that slurry 1 leaks out from the short-necked triangular funnel with an outflow of 21ml. If a 500g weight is placed on the surface of the slurry 1 in the short-necked triangular funnel, 98ml will flow out within 3 minutes.

[0061] Butylparaben itself has antibacterial and antiseptic effects. The purpose of adding it initially was to improve the antibacterial and antiseptic properties of the magnetic slurry, after all, it must be used in the hospital environment. However, it was found that when its addition amount was increased to a certain level (the ratio with manganese-zinc ferrite exceeded 5%), the magnetic slurry became similar to "toothpaste" and required a certain amount of extrusion force to be squeezed out.

[0062] Comparative Example 2

[0063] The butyl hydroxybenzoate in this example is completely replaced by methylisothiazolinone, and the rest remain unchanged, and the final product is slurry 2.

[0064] The magnetic properties of slurry 2 after magnetization are the same as those of the magnetic slurry prepared in this embodiment. A 150ml short-necked triangular funnel in the laboratory is used for testing. 150ml of slurry 2 is poured into the short-necked triangular funnel. After 10 minutes of observation, slurry 1 is found to leak out from the short-necked triangular funnel with an outflow of 24ml. If a 500g weight is placed on the surface of slurry 2 in the short-necked triangular funnel, 92ml will flow out within 3 minutes.

[0065] That is to say, when the addition amount is low, the use of butyl hydroxybenzoate or methylisothiazolinone will not make the magnetic slurry have the properties similar to "toothpaste". The magnetic slurry with such properties is not easy to settle and the magnetic force is evenly distributed.

[0066] Comparative Example 3

[0067] The butyl hydroxybenzoate in this example is completely replaced with chitosan quaternary ammonium salt of the same mass, that is, the formula is: 2000 g of manganese zinc ferrite, 820 g of chitosan quaternary ammonium salt, 1160 g of water, and the rest remains unchanged, and the final slurry 3 is prepared.

[0068] The magnetic properties of slurry 3 after magnetization are the same as those of the present embodiment. A 150ml short-necked triangular funnel in the laboratory is used for testing. 150ml of slurry 3 is poured into the short-necked triangular funnel. After 10 minutes of observation, it is found that slurry 1 leaks out from the short-necked triangular funnel with an outflow of 19ml. If a 500g weight is placed on the surface of the slurry 3 in the short-necked triangular funnel, 105ml will flow out within 3 minutes.

[0069]

[0070] It can be seen that when the addition amount of butyl hydroxybenzoate and methylisothiazolinone is reduced, the prepared magnetic slurry will not form a toothpaste-like state.

[0071] Embodiment 7

[0072] This embodiment is a preferred solution of the fourth embodiment, and specifically discloses a method for making a magnetic fluid, comprising the following steps:

[0073] 1000g carbonyl iron oxide, 70g diacetone acrylamide, 750g glycerol, and 880g water were ball-milled in a ball mill. The rotation direction of the ball mill remained unchanged during the ball milling. The ball milling was performed for 24 hours, and the defoaming was performed by vacuum defoaming. After the defoaming was completed, a magnetic fluid was obtained. The carbonyl iron oxide was in powder form, with a powder particle size of D50 = 0.8 μm and a specific surface area of ​​32.2 m 2 / g.

[0074] When the magnetic fluid is energized by the electromagnet to generate magnetic force, the magnetic fluid is easily magnetized.

[0075] In addition, it should be noted that the magnetic fluid is not easy to adhere to the inner wall of the shell 21. The specific test is: an aluminum alloy tank is used to hold the magnetic fluid, and the surface roughness of the inner wall of the aluminum alloy tank has an average value of 1.6μm. The aluminum alloy tank filled with magnetic fluid is allowed to stand for 5 minutes. A valve is installed at the bottom of the aluminum alloy tank. The valve is opened to drain the magnetic fluid in the aluminum alloy tank. The inner wall of the aluminum alloy tank is wiped with dry non-woven cloth until all possible attachments on the surface are wiped clean. The adhesion rate = (m1-m2) / S, m1 is the mass of the non-woven cloth after wiping, m2 is the mass of the non-woven cloth before wiping, and S is the total area of ​​the inner wall of the aluminum alloy tank.

[0076] The adhesion rate of the magnetic fluid in this embodiment is less than or equal to 88 mg / cm 2This is because part of the mixture of glycerol and water will adhere to the inner wall of the aluminum alloy tank. As a reference, the reference agent is made by mixing 750g glycerol and 880g water. The reference agent is used to replace the magnetic fluid. The final adhesion rate of the reference agent is 37mg / cm 2 .

[0077] Comparative Example 4

[0078] The diacetone acrylamide in this example is completely replaced by glycerol, and the final formula is: 1000g carbonyl iron oxide, 820g glycerol, 880g water, and the rest remains unchanged, and finally the fluid 1 is obtained. The fluid 1 is tested with reference to the test method of the adhesion rate in this example, and the adhesion rate of the fluid 1 is 1975mg / cm 2 .

[0079] Comparative Example 5

[0080] The diacetone acrylamide in this embodiment is completely replaced by water, and the final formula is: 1000g carbonyl iron oxide, 750g glycerol, 950g water, and the rest remains unchanged, and finally the fluid 2 is obtained. The fluid 2 is tested with reference to the test method of the adhesion rate in this embodiment, and the adhesion rate of the fluid 2 is 1032mg / cm 2 .

[0081] Comparative Example 6

[0082] The amount of diacetone acrylamide in this example was increased, and the final formula was: 1000g carbonyl iron oxide, 110g diacetone acrylamide, 750g glycerol, 880g water, and the rest remained unchanged, and finally fluid object 3 was obtained. Fluid object 3 was tested with reference to the test method of adhesion rate in this example, and the adhesion rate of fluid object 3 was 93mg / cm 2 .

[0083] Comparative Example 7

[0084] The amount of diacetone acrylamide in this embodiment was reduced, and the final formula was: 1000g carbonyl iron oxide, 50g diacetone acrylamide, 750g glycerol, 880g water, and the rest remained unchanged, and finally the fluid 4 was obtained. The fluid 4 was tested with reference to the test method of the adhesion rate in this embodiment, and the adhesion rate of the fluid 4 was 252mg / cm 2 .

[0085]

[0086]

[0087] The addition of diacetone acrylamide can significantly reduce the adhesion rate of the magnetic fluid on the inner wall of the shell 21, making it difficult for the magnetic fluid to adhere to the inner wall of the shell 21, thereby making the magnetic field in the shell 21 evenly distributed and concentrated, which is more conducive to the magnetic compensation ring 20 to perform the magnetic compensation function.

[0088] It should be noted that even if the magnetic fluid settles slightly in the shell 21, it will not affect the magnetic compensation function, because in actual use, the permanent magnet 12 is located below the shell 21, and the sedimentation can concentrate the magnetic force to control the magnetic force of the permanent magnet 12.

[0089] The matters not described in detail in the present invention are all known technologies to those skilled in the art.

[0090] The preferred specific embodiments of the present invention are described in detail above. It should be understood that a person skilled in the art can make many modifications and changes based on the concept of the present invention without creative work. Therefore, any technical solution that can be obtained by a person skilled in the art through logical analysis, reasoning or limited experiments based on the concept of the present invention on the basis of the prior art should be within the scope of protection determined by the claims.

Claims

1. A digestive tract capsule pH detection device, characterized in that: Includes capsule detector; A magnetic driving mechanism for driving and controlling the capsule detector; The magnetic driving mechanism comprises a magnetic airbag, the magnetic airbag comprises an airbag bag, the inner circle of the airbag bag is provided with a pleated structure; a plurality of inner bags are provided in the inner cavity of the airbag bag; one end of each of the inner bags is connected to the inner wall of the airbag bag close to the pleated structure, and the other end of each of the inner bags is connected to the outer bag; the interiors of the inner bags and the outer bags are both filled with magnetic slurry; an inflation hole is provided on the airbag bag, and the inflation hole is connected to the air pump through an inflation pipeline; An electromagnet rod is also provided inside the outer bag; The inner bag is a semi-ellipsoidal structure, the long axis direction of the inner bag is arranged along the radial direction of the air bag, one end of the inner bag in the short axis direction is connected to the inner wall of the air bag close to the pleated structure; the other end of the inner bag in the short axis direction is connected to the outer bag; The outer bag is a rugby ball-shaped structure, and the long axis direction of the outer bag is coaxial with the long axis direction of the inner bag.

2. The digestive tract capsule pH detection device according to claim 1, characterized in that: The volume ratio of the outer bag to the inner bag is 3-3.5:

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3. The digestive tract capsule pH detection device according to claim 1, characterized in that: A vibrating ball is also provided at the connection point between two adjacent inner bags and the outer bag, and the vibrating ball is fixedly connected to the inner wall of the airbag bag.

4. The digestive tract capsule pH detection device according to claim 1, characterized in that: The outer side of the magnetic airbag is provided with a magnetic compensation ring; the outer ring of the airbag bag is sealed and connected with the inner ring of the magnetic compensation ring; The magnetic compensation ring comprises a shell, in which a ferroelectric medium is arranged, a magnetic fluid containing cavity is formed between the outer wall of the ferroelectric medium and the inner wall of the shell, and the magnetic fluid containing cavity is filled with magnetic fluid; an electromagnet block is arranged inside the ferroelectric medium.

5. The digestive tract capsule pH detection device according to claim 4, characterized in that: The cross section of the ferroic medium is a right triangle, and two right-angled sides corresponding to the ferroic medium are in contact and connected with the inner wall of the shell.

6. The digestive tract capsule pH detection device according to claim 5, characterized in that: A convex portion is arranged on the oblique side corresponding to the ferroelectric medium, and the convex portion and the inner wall of the shell form a magnetic fluid containing cavity.

7. The digestive tract capsule pH detection device according to claim 6, characterized in that: The cross section of the raised portion is arc-shaped.

8. The digestive tract capsule pH detection device according to claim 4, characterized in that: The upper end of the shell is provided with a drain valve, which is connected to the magnetic fluid containing chamber; the lower end of the shell is provided with a magnetic fluid input valve and a magnetic fluid output valve, which are both connected to the magnetic fluid containing chamber, and the magnetic fluid input valve and the magnetic fluid output valve are both externally connected to a peristaltic pump.

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