Nanopharmaceutical production apparatus based on microfluidic technology

Abstract

The application relates to the microfluidic technology field and discloses a nanometer drug production device based on microfluidic technology, which comprises a host and a syringe, the surface of the host is rotationally connected with a turnover door, a closed cavity is formed between the host and the turnover door, and a through groove is arranged in the inner wall of the closed cavity. The nanometer drug production device based on microfluidic technology is provided with the host, the syringe, a microfluidic chip box, a chip clamp module, a heating module and a syringe advancing module, the syringe is connected to the liquid inlet of the microfluidic chip box, the host is internally provided with the chip clamp module, the heating module and the syringe advancing module, the chip clamp module clamps the microfluidic chip box, the syringe is installed on the microfluidic chip box and is connected to the syringe advancing module, the syringe advancing module controls the pushing speed of the syringe, and the heating module heats raw material liquid in the syringe, so as to control the flow rate of the raw material liquid into the microfluidic chip box and keep the temperature of the raw material liquid.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of microfluidic technology, and particularly to a nanopharmaceutical production device based on microfluidic technology. BACKGROUND

[0002] Microfluidic technology is a technology for precisely controlling and manipulating microfluids, which is mainly realized by controlling microfluids through micron to sub-millimeter channels in a microfluidic chip box. The chip is an operation platform, and is based on analytical chemistry, relies on micro-electro-mechanical processing technology, has a micro-pipe network as a structural feature, and takes life science as a current main application object. It is the focus of the current development of micro-total analysis systems. The goal is to integrate the functions of the entire laboratory, including sampling, dilution, reagent addition, reaction, synthesis, detection, and other basic operation units, into a micron-scale chip.

[0003] When using a microfluidic chip box, sample preparation, reaction, synthesis, and detection of the analysis process all require precise control of the flow rate of the raw material liquid injected into the microfluidic chip box, and the temperature of the raw material liquid needs to be maintained during the injection process. Currently, manual operation is usually used for injection, which is relatively cumbersome and difficult to control the flow rate and maintain the temperature of the raw material liquid. SUMMARY

[0004] In view of the deficiencies of the prior art, the present application provides a nanopharmaceutical production device based on microfluidic technology, which solves the problems mentioned in the background.

[0005] The present application provides the following technical solution: a nanopharmaceutical production device based on microfluidic technology, comprising: a host computer, a chip clamp module, a microfluidic chip box, a heating module, a liquid receiving module, a syringe advancing module, and a syringe.

[0006] The microfluidic chip box is installed in the chip card slot of the chip clamp module, the chip clamp module is installed on the side wall of the host computer, and the heating module is installed below the chip clamp module and cooperates with the chip clamp module to form a syringe channel.

[0007] The moving end of the syringe advancing module can move back and forth in the vertical direction, the lower end of the syringe is arranged on the moving end of the syringe advancing module, and the upper end of the syringe penetrates through the syringe channel and is connected to the liquid inlet of the microfluidic chip box.

[0008] The moving end of the liquid receiving module can move back and forth in the horizontal direction, the moving end of the liquid receiving module is provided with a liquid receiving pipe, and the pipe opening of the liquid receiving pipe is connected to the liquid outlet of the microfluidic chip box.

[0009] Preferably, the chip clamp module comprises an upper plate, a lower plate, a left mounting block, a right mounting block and a spring damping structure, the upper plate is mounted on the top of the lower plate, a chip card slot is formed between the upper plate and the lower plate, the left mounting block and the right mounting block are respectively located on the left and right sides of the upper plate and are connected with the upper plate through corresponding spring damping structures.

[0010] Preferably, a chip identification hole is formed on the upper plate, and pin shaft holes are arranged on the left and right sides of the upper plate.

[0011] Preferably, the microfluidic chip box comprises a shell and a microfluidic chip arranged in the shell, the liquid inlet and the liquid outlet are arranged on the lower surface of the shell, a luer joint is arranged on the liquid inlet, and the liquid inlet is connected with the syringe through the luer joint.

[0012] Preferably, a microfluidic channel is arranged in the microfluidic chip, the starting end of the microfluidic channel is communicated with the liquid inlet, and the end of the microfluidic channel is communicated with the liquid outlet.

[0013] The upper surface of the shell of the microfluidic chip box is provided with a mounting groove for mounting a magnet, the upper plate of the chip clamp module is provided with a chip suction piece, the chip suction piece is arranged one-to-one corresponding to the magnet in the mounting groove and constitutes a first magnetic suction assembly, and the microfluidic chip box is connected with the chip card slot of the chip clamp module through the first magnetic suction assembly.

[0014] Preferably, the heating module comprises a heating seat, a heating rod and a temperature sensor.

[0015] A heating groove vertically penetrating from the upper end surface to the lower end surface is formed on one side of the heating seat, and the heating rod and the temperature sensor are respectively arranged on the other side of the heating seat.

[0016] Preferably, the lower plate of the chip clamp module and the heating seat are provided with a matched second magnetic suction assembly, and the second magnetic suction assembly can keep the syringe channel formed by the cooperation of the chip clamp module and the heating seat in a folded state.

[0017] Preferably, the heating module further comprises a heating sleeve, the heating sleeve is embedded in the heating groove, and the syringe is inserted into the heating sleeve.

[0018] Preferably, the liquid receiving module comprises a liquid receiving pipe clamp, a rack, a mounting block, a gear and a first driving motor.

[0019] The installation block is installed in the interior of the main machine, the first driving motor is installed at the bottom of the installation block, the gears are respectively installed in the interior of the installation block, and the central shafts of the gears are connected with the output shaft of the first driving motor, the rack is installed in the strip-shaped recess of the installation block and is engaged with the gears, the two ends of the rack respectively extend out of the installation block, the liquid receiving pipe clamp is installed at one end of the rack, and the liquid receiving pipe is clamped on the liquid receiving pipe clamp.

[0020] Preferably, the injector advancing module comprises a first mounting plate, a second mounting plate, a third mounting plate, a ball screw base, a ball screw, a sliding block, an injector push piece and a second driving motor.

[0021] The first mounting plate, the second mounting plate and the third mounting plate are sequentially arranged from bottom to top and are parallel to each other, the ball screw base is installed on the second mounting plate, the second driving motor is installed on the third mounting plate, the surface of the first mounting plate is inlaid with a bearing, the lower end of the ball screw is installed on the first mounting plate through the bearing, the upper end of the ball screw passes through the second mounting plate and is connected with the ball screw base, and the output shaft of the second driving motor is connected with the top end of the ball screw through a shaft coupling.

[0022] The sliding block is sleeved on the ball screw, and the injector push piece is coaxially arranged with the injector and is connected with the front end of the sliding block.

[0023] Preferably, the injector advancing module further comprises a pressure sensor, a contact sensor, a drag chain and a sensor sensing sheet.

[0024] The pressure sensor is installed on the injector push piece and is used for monitoring the pressure of the injector push piece when the injector push piece pushes the injector, one end of the drag chain is connected with the rear end of the sliding block, the sensor sensing sheet is installed on the side surface of the sliding block, and the contact sensor is installed on the surface of the second mounting plate and corresponds to the position of the sensor sensing sheet.

[0025] Preferably, a turnover door is further included, the turnover door is rotationally connected with the outer side wall of the main machine, and a containing cavity is defined between the main machine and the turnover door.

[0026] The chip clamp module, the microfluidic chip box, the heating module, the injector, the liquid receiving pipe of the liquid receiving module and the injector push piece of the injector advancing module are all located in the containing cavity.

[0027] Preferably, the side wall of the containing cavity is composed of a first side wall, a second side wall and the arc-shaped side wall of the turnover door, a long strip-shaped through groove is formed in the first side wall, and a through hole is formed in the second side wall.

[0028] The chip clamp module and the heating module are mounted on the first sidewall, the moving end of the injector advancing module extends into the inside of the accommodating cavity through the through slot, and the moving end of the liquid receiving module extends into the inside of the accommodating cavity through the through hole.

[0029] Preferably, the main machine further comprises a human-computer interaction module, the human-computer interaction module comprises a touch screen, a power-on / off button, an indicator light and a mounting rack, the mounting rack is mounted on the main machine, the mounting rack is provided with a mounting window, the touch screen is mounted in the mounting window of the mounting rack, and the power-on / off button and the indicator light are mounted on the mounting rack.

[0030] Preferably, the touch screen is rotationally connected with the mounting rack.

[0031] Preferably, the main machine comprises a control unit, and the micro-fluidic chip box, the heating module, the liquid receiving module, the injector advancing module, the touch screen, the power-on / off button and the indicator light are electrically connected with the control unit.

[0032] Compared with the prior art, the application has the following beneficial effects:

[0033] 1. The nanometer drug production equipment based on micro-fluidic technology, by setting the main machine, the injector, the micro-fluidic chip box, the chip clamp module, the heating module and the injector advancing module, the injector is connected to the liquid inlet of the micro-fluidic chip box, the chip clamp module, the heating module and the injector advancing module are arranged in the main machine, the chip clamp module clamps the micro-fluidic chip box, the injector is mounted on the injector advancing module, the injector advancing module controls the speed of the injector, and the heating module heats the raw material liquid in the injector, thereby controlling the flow rate of the raw material liquid entering the micro-fluidic chip box and maintaining the temperature of the raw material liquid.

[0034] 2. The nanometer drug production equipment based on micro-fluidic technology, when the chip clamp module and the heating module are buckled, a closed through hole is formed between the two, the injector is located in the inside of the closed through hole, which can prevent the injector from deviating during injection and avoid liquid leakage at the connection between the injector and the micro-fluidic chip box.

[0035] 3. The nanometer drug production equipment based on micro-fluidic technology, the heating module can tightly adhere to the pipe wall of the injector through different specifications and sizes of sleeves, and directly heats the raw material liquid through heat conduction, which can not only more accurately control the heating temperature, heating time and heating object, but also can meet the experimental requirements under different working conditions.

[0036] 4. The nanometer medicine production equipment based on microfluidic technology, which adopts a motor screw module direct connection mode to push the syringe, so as to ensure the pushing precision of the syringe, and the syringe pushing module contains a sensor array, which can accurately sense the positions of the pushing piece and the syringe, so as to realize accurate automatic pushing and improve the pushing precision of the raw material liquid.

[0037] 5. The nanometer medicine production equipment based on microfluidic technology, which is provided with a liquid receiving module, and the liquid receiving pipe clamp of the liquid receiving module can clamp two liquid receiving pipes at the same time, one of which is used for receiving waste liquid, and the other is used for receiving a synthesized sample, and the purpose of receiving waste liquid is to obtain a more pure target sample. BRIEF DESCRIPTION OF DRAWINGS

[0038] Figure 1 It is a structural schematic diagram of the present application;

[0039] Figure 2 It is a structural schematic diagram of the chip clamp module of the present application;

[0040] Figure 3 It is a partial structural schematic diagram of the chip clamp module of the present application;

[0041] Figure 4 It is a structural schematic diagram of the microfluidic chip box of the present application;

[0042] Figure 5 It is a structural schematic diagram of the liquid outlet and liquid inlet of the present application;

[0043] Figure 6 It is a structural schematic diagram of the chip clamp module, the microfluidic chip box and the heating module of the present application after assembly;

[0044] Figure 7 It is a structural schematic diagram of the heating module of the present application;

[0045] Figure 8 It is a structural schematic diagram of the heating module of the present application;

[0046] Figure 9 It is a structural schematic diagram of the liquid receiving module of the present application;

[0047] Figure 10 It is a structural schematic diagram of the syringe pushing module of the present application;

[0048] Figure 11 It is a structural schematic diagram of the man-machine interaction module of the present application.

[0049] In the figure: 1, host; 2, turnover door; 3, chip clamp module; 31, upper plate; 311, chip identification hole; 312, pin shaft hole; 32, lower plate; 321, vertical hole; 33, chip card slot; 34, left mounting block; 35, right mounting block; 36, spring damping structure; 4, microfluidic chip box; 41, liquid outlet; 42, liquid inlet; 43, luer connector; 44, mounting groove; 5, heating module; 51, heating seat; 52, heating groove; 53, heating rod; 54, temperature sensor; 55, heating sleeve; 6, liquid receiving module; 61, liquid receiving tube clamp; 62, rack; 63, mounting block; 64, gear; 65, first drive motor; 7, syringe advancing module; 70, bearing; 71, shaft coupling; 72, contact sensor; 73, screw base; 74, drag chain; 75, ball screw; 76, sensor sensing sheet; 77, sliding block; 78, syringe push piece; 791, first mounting plate; 792, second mounting plate; 793, third mounting plate; 710, second drive motor; 8, human-computer interaction module; 81, touch screen; 82, on-off button; 83, indicator light; 84, mounting bracket; 9, syringe; 10, liquid receiving tube. DETAILED DESCRIPTION

[0050] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0051] Please refer to Figures 1-5 The nano drug production equipment based on microfluidic technology comprises a host 1, a chip clamp module 3, a microfluidic chip box 4, a heating module 5, a liquid receiving module 6, a syringe advancing module 7, and a syringe 9. The microfluidic chip box 4 is installed in the chip card slot 33 of the chip clamp module 3. The chip clamp module 3 is installed on the side wall of the host 1. The heating module 5 is installed below the chip clamp module 3 and cooperates with the chip clamp module 3 to form a syringe channel. The moving end of the syringe advancing module 7 can move back and forth in the vertical direction. The lower end of the syringe 9 is arranged on the moving end of the syringe advancing module 7. The upper end of the syringe 9 penetrates through the syringe channel and is connected to the liquid inlet 42 of the microfluidic chip box 4.

[0052] The moving end of the liquid receiving module 6 can move back and forth in the horizontal direction. The moving end of the liquid receiving module 6 is provided with a liquid receiving tube 10. The tube opening of the liquid receiving tube 10 is connected to the liquid outlet 41 of the microfluidic chip box 4.

[0053] Please refer to Figures 2-3The chip clamp module 3 comprises an upper plate 31, a lower plate 32, a left mounting block 34, a right mounting block 35 and a spring damping structure 36, the upper plate 31 is mounted on the top of the lower plate 32, a chip card slot 33 is formed between the upper plate 31 and the lower plate 32, the left mounting block 34 and the right mounting block 35 are respectively located on the left and right sides of the upper plate 31 and are connected with the upper plate 31 through corresponding spring damping structures 36, a chip identification hole 311 is formed on the upper plate 31, pin shaft holes 312 are formed on the left and right sides of the upper plate 31, a plurality of vertical holes 321 are formed on the lower plate 32, the spring damping structure 36 is mounted on the inner wall of the pin shaft hole 312, and the left mounting block 34 and the right mounting block 35 are connected with the upper plate 31 through the spring damping structure 36, so that the chip clamp module 3 can be controlled to flip and stay at any position within the movable range.

[0054] Referring to Figures 4-5 The microfluidic chip box 4 comprises a shell and a microfluidic chip arranged in the shell, an inlet 42 and an outlet 41 are arranged on the lower surface of the shell, a luer joint 43 is arranged on the inlet 42, the inlet 42 is connected with the syringe 9 through the luer joint 43, a microfluidic channel is arranged in the microfluidic chip, the starting end of the microfluidic channel is communicated with the inlet 42, and the end of the microfluidic channel is communicated with the outlet 41.

[0055] Referring to Figures 5-6 An installation groove 44 is arranged on the upper surface of the shell of the microfluidic chip box 4, the installation groove 44 is used for mounting a magnet, an adsorbing piece (not shown in the figure) is arranged on the upper plate 31 of the chip clamp module 3, the adsorbing piece and the magnet in the installation groove 44 are arranged one by one and form a first magnetic adsorption assembly, and the microfluidic chip box 4 is adsorbed and connected in the chip card slot 33 of the chip clamp module 3 through the first magnetic adsorption assembly.

[0056] Referring to Figure 7 The heating module 5 comprises a heating seat 51, a heating rod 53 and a temperature sensor 54, the heating seat 51 is provided with a heating groove 52 vertically penetrating from the upper end surface to the lower end surface, the heating rod 53 and the temperature sensor 54 are arranged on the other side of the heating seat 51, the temperature sensor 54 adopts an existing device, for example, a temperature sensor 54 of ZIM91-D5-L30-W50-V24 type,

[0057] Specifically, in the embodiment, the upper end surface of the heating seat 51 comprises a plane and an arc-shaped inclined surface connected in sequence from back to front, the arc-shaped inclined surface gradually inclines downward along the direction from back to front, the lower plate 32 is in an L-shaped structure as a whole, a vertical hole 321 is arranged on the vertical part of the lower plate 32, the horizontal part of the lower plate 32 comprises two oppositely arranged connecting ends, the upper end surface of the connecting end is connected with the upper plate 31, and the lower end surface of the connecting end is arranged in an arc-shaped inclined surface and used for matching the arc-shaped inclined surface of the heating seat 51.

[0058] The lower plate 32 of the chip clamp module 3 is provided with a second magnetic assembly matched with the heating seat 51, which can keep the injector channel formed by the chip clamp module 3 and the heating seat 51 in a folded state, at this time, the injector 9 can only move up and down along the injector channel. By turning over the chip clamp module 3 by external force, the injector channel can be changed from the folded state to the open state.

[0059] Please refer to Figure 8 In a specific embodiment, the heating module 5 further comprises a heating sleeve 55, which is embedded in the heating groove 52 and used to wrap the wall of the injector 9 to improve the heating effect. Different specifications of the heating sleeve 55 can be matched with different specifications of the injector 9, and the operator can see the model mark (for example, 5ml) on the heating sleeve 55 through the vertical hole 321 of the chip clamp module 3, thereby confirming the corresponding injector 9 model of the heating sleeve 55.

[0060] Please refer to Figure 9 The liquid receiving module 6 comprises a liquid receiving tube clamp 61, a rack 62, a mounting block 63, a gear 64 and a first driving motor 65. The mounting block 63 is installed in the interior of the main machine 1, the first driving motor 65 is installed at the bottom of the mounting block 63, the gear 64 is installed in the interior of the mounting block 63 respectively, the central shaft of the gear 64 is connected with the output shaft of the first driving motor 65, the rack 62 is installed in the strip-shaped groove of the mounting block 63 and engaged with the gear 64, the two ends of the rack 62 respectively extend out of the mounting block 63, the liquid receiving tube clamp 61 is installed at one end of the rack 62, and the liquid receiving tube 10 is clamped on the liquid receiving tube clamp 61.

[0061] Preferably, the liquid receiving tube clamp 61 is fixed in the groove of the rack 62 by magnetic adsorption. In this way, it is convenient to replace different specifications and sizes of reagent tube clamps.

[0062] Please refer to Figure 10The injector pushing module 7 comprises a first mounting plate 791, a second mounting plate 792, a third mounting plate 793, a screw rod base 73, a ball screw 75, a sliding block 77, an injector pushing piece 78 and a second driving motor 710. The first mounting plate 791, the second mounting plate 792 and the third mounting plate 793 are sequentially arranged from bottom to top and are parallel to each other. The screw rod base 73 is mounted on the second mounting plate 792. The second driving motor 710 is mounted on the third mounting plate 793. A bearing 70 is embedded on the surface of the first mounting plate 791. The lower end of the ball screw 75 is mounted on the first mounting plate 791 through the bearing 70. The upper end of the ball screw 75 penetrates through the second mounting plate 792 and is connected with the screw rod base 73. The output shaft of the second driving motor 710 is connected with the top end of the ball screw 75 through a shaft coupling 71. The sliding block 77 is sleeved on the ball screw 75. The injector pushing piece 78 is coaxially arranged with the injector 9 and is mounted and connected with the front end of the sliding block 77.

[0063] The injector pushing module 7 further comprises a pressure sensor, a contact sensor 72, a drag chain 74 and a sensor sensing sheet 76. The pressure sensor is mounted on the injector pushing piece 78 and is used for monitoring the pressure of the injector pushing piece 78 when pushing the injector 9. The pressure sensor adopts an existing device, for example, a pressure sensor of ZKV01-1-A-N model. One end of the drag chain 74 is mounted and connected with the rear end of the sliding block 77. The sensor sensing sheet 76 is mounted on the side surface of the sliding block 77. The contact sensor 72 is mounted on the surface of the second mounting plate 792 corresponding to the position of the sensor sensing sheet 76. The contact sensor 72 is used for sensing the close contact of the sensor sensing sheet 76, thereby positioning the initial position of the injector pushing piece 78. The contact sensor 72 adopts an existing device, for example, a contact sensor 72 of 72ZJF49-U25-N model.

[0064] The device further comprises a turnover door 2 which is rotationally connected with the outer side wall of the main machine 1. A containing cavity is defined between the main machine 1 and the turnover door 2. The first mounting plate 791, the second mounting plate 792, the third mounting plate 793, the screw rod base 73, the ball screw 75, the second driving motor 710 of the injector pushing module 7 and the mounting block 63, the gear 64 and the first driving motor 65 of the liquid receiving module 6 are located outside the containing cavity. The chip clamp module 3, the microfluidic chip box 4, the heating module 5, the injector 9, the liquid receiving pipe 10 of the liquid receiving module 6 and the injector pushing piece 78 of the injector pushing module 7 are located in the containing cavity.

[0065] The side wall of the accommodating cavity is composed of the first side wall, the second side wall and the arc-shaped side wall of the turnover door 2, the first side wall is provided with a long slot, the second side wall is provided with a through hole, the chip clamp module 3 and the heating module 5 are installed on the first side wall, the moving end of the injector advancing module 7 extends into the interior of the accommodating cavity through the slot, the moving end of the liquid receiving module 6 extends into the interior of the accommodating cavity through the through hole, most components of the injector advancing module 7 and the liquid receiving module 6 are shielded outside the accommodating cavity, and the user experience can be improved.

[0066] In the embodiment, the first side wall and the second side wall are both planar structures and have a preset included angle (for example, 90°) between the two side walls. In other embodiments, the first side wall and the second side wall can also be arc surfaces, and the first side wall and the second side wall are integrated to form an arc-shaped side wall.

[0067] Please refer to Figure 11 The host 1 further includes a human-computer interaction module 8, which includes a touch screen 81, a power-on / off button 82, an indicator light 83 and a mounting bracket 84. The mounting bracket 84 is mounted on the host 1 and is provided with a mounting window. The touch screen 81 is mounted in the mounting window of the mounting bracket 84, and the power-on / off button 82 and the indicator light 83 are both mounted on the mounting bracket 84.

[0068] In the embodiment, the human-computer interaction module 8 and the turnover door 2 are both located on the front side of the host 1. When the turnover door 2 is opened, the operator can see the touch screen 81 and the components in the accommodating cavity at the same time, so as to facilitate operation.

[0069] Preferably, the touch screen 81 is rotationally connected with the mounting bracket 84. In this way, the screen can be flipped up by a certain angle, which conforms to the ergonomic design and greatly enhances the interaction experience between people and equipment.

[0070] The host 1 includes a control unit, and the microfluidic chip box 4, the heating module 5, the liquid receiving module 6 and the injector advancing module 7 are all electrically connected with the control unit. The touch screen 81, the power-on / off button 82 and the indicator light 83 are all electrically connected with the control unit.

[0071] Two injectors 9 are respectively connected to the liquid inlet 42 of the microfluidic chip box 4 through the luer joint 43, and the injectors 9 are located in the closed through hole formed between the lower plate 32 and the heating seat 51, the surface of the injector 9 is attached to the inner wall of the heating groove 52, the heating rod 53 is started, the temperature of the raw material liquid of the injector 9 is controlled, the bottom of the injector 9 is connected with the injector 9 push piece 78, the liquid receiving tube 10 is placed in the liquid receiving tube clamp 61, the first driving motor 65 is started, the output shaft of the first driving motor 65 drives the gear 64 to rotate, the gear 64 drives the rack 62 to move, the rack 62 drives the liquid receiving tube clamp 61 to move, so that one of the liquid receiving tubes 10 moves to the liquid outlet 41 of the microfluidic chip box 4, the second driving motor 710 is started, the second driving motor 710 drives the ball screw 75 to rotate, the sliding block 77 sleeved on the ball screw 75 also moves, and one end of the injector 9 is driven to move, so that the raw material liquid is injected into the microfluidic chip box 4.

[0072] Although the embodiments of the present application have been shown and described, it is to be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present application, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A nanodrug production apparatus based on microfluidic technology, characterized by, The application relates to a microfluidic chip box and a chip clamp module. The microfluidic chip box (4) is installed in a chip card slot (33) of the chip clamp module (3), the chip clamp module (3) is rotationally installed on the side wall of the main machine (1), the heating module (5) is installed below the chip clamp module (3) and cooperates with the chip clamp module (3) to form a syringe channel, and the syringe channel is opened or closed through the overturning movement of the chip clamp module (3). The moving end of the syringe propelling module (7) can move back and forth in the vertical direction, the lower end of the syringe (9) is arranged on the moving end of the syringe propelling module (7), and the upper end of the syringe (9) penetrates through the syringe channel and is connected with the liquid inlet (42) of the microfluidic chip box (4). The moving end of the liquid receiving module (6) can move back and forth in the horizontal direction, the moving end of the liquid receiving module (6) is provided with a liquid receiving pipe (10), and the pipe opening of the liquid receiving pipe (10) is connected with the liquid outlet (41) of the microfluidic chip box (4). The microfluidic chip box (4) comprises a microfluidic chip, the microfluidic chip is internally provided with a microfluidic channel, the starting end of the microfluidic channel is communicated with the liquid inlet (42), and the tail end of the microfluidic channel is communicated with the liquid outlet (41). The upper surface of the microfluidic chip box (4) is provided with a mounting groove (44), the mounting groove (44) is used for mounting a magnet, the upper plate (31) of the chip clamp module (3) is provided with a chip suction piece, the chip suction piece is arranged in one-to-one correspondence with the magnets in the mounting grooves (44) and forms a first magnetic suction assembly, and the microfluidic chip box (4) is connected in the chip card slot (33) of the chip clamp module (3) through the first magnetic suction assembly. The lower plate (32) of the chip clamp module (3) and the heating seat (51) of the heating module (5) are provided with a matched second magnetic suction assembly, and the second magnetic suction assembly can keep the syringe channel formed by the cooperation of the chip clamp module (3) and the heating seat (51) in a closed state. The chip clamp module (3) comprises an upper plate (31), a lower plate (32), a left mounting block (34), a right mounting block (35) and a spring damping structure (36), the upper plate (31) is installed on the top of the lower plate (32), a chip card slot (33) is formed between the upper plate (31) and the lower plate (32), the left mounting block (34) and the right mounting block (35) are respectively arranged on the left side and the right side of the upper plate (31) and are connected with the upper plate (31) through corresponding spring damping structures (36).

2. The microfluidic technology-based nanodrug production apparatus according to claim 1, characterized by, A chip identification hole (311) is formed in the upper plate (31), pin shaft holes (312) are formed in the left side and the right side of the upper plate (31), and a plurality of vertical holes (321) are formed in the lower plate (32).

3. The microfluidic technology-based nanodrug production apparatus according to claim 2, characterized by, ​ 4. The microfluidic technology-based nanodrug production apparatus according to claim 1, wherein, The microfluidic chip box (4) comprises a shell and a microfluidic chip arranged in the shell, the liquid inlet (42) and the liquid outlet (41) are arranged on the lower surface of the shell, and the liquid inlet (42) is provided with a luer joint (43), and the liquid inlet (42) is connected with the syringe (9) through the luer joint (43).

5. The microfluidic technology-based nanodrug production apparatus according to claim 1, wherein, The heating module (5) comprises a heating seat (51), a heating rod (53) and a temperature sensor (54); One side of the heating seat (51) is provided with a heating groove (52) vertically penetrating from the upper end surface to the lower end surface, and the heating rod (53) and the temperature sensor (54) are respectively installed on the other side of the heating seat (51).

6. The microfluidic technology-based nanomedicine production apparatus according to claim 5, wherein, The heating module (5) further comprises a heating sleeve (55), the heating sleeve (55) is embedded in the heating groove (52), and the syringe (9) is inserted into the heating sleeve (55).

7. The microfluidic technology-based nanodrug production apparatus according to claim 1, wherein, The liquid receiving module (6) comprises a liquid receiving pipe clamp (61), a rack (62), a mounting block (63), a gear (64) and a first driving motor (65). The mounting block (63) is installed in the interior of the main machine (1), the first driving motor (65) is installed on the bottom of the mounting block (63), the gear (64) is installed in the interior of the mounting block (63), the central shaft of the gear (64) is connected with the output shaft of the first driving motor (65), the rack (62) is installed in the strip-shaped groove of the mounting block (63) and is engaged with the gear (64), the two ends of the rack (62) respectively extend out of the mounting block (63), the liquid receiving pipe clamp (61) is installed on one end of the rack (62), and the liquid receiving pipe (10) is clamped on the liquid receiving pipe clamp (61).

8. The microfluidic technology-based nanodrug production apparatus according to claim 1, wherein, The syringe advancing module (7) comprises a first mounting plate (791), a second mounting plate (792), a third mounting plate (793), a screw rod base (73), a ball screw (75), a sliding block (77), a syringe push piece (78) and a second driving motor (710). The first mounting plate (791), the second mounting plate (792) and the third mounting plate (793) are arranged in sequence from bottom to top and are parallel to each other, the screw rod base (73) is installed on the second mounting plate (792), the second driving motor (710) is installed on the third mounting plate (793), the surface of the first mounting plate (791) is embedded with a bearing (70), the lower end of the ball screw (75) is installed on the first mounting plate (791) through the bearing (70), the upper end of the ball screw (75) penetrates through the second mounting plate (792) and is connected with the screw rod base (73), and the output shaft of the second driving motor (710) is connected with the top end of the ball screw (75) through a shaft coupling (71). The sliding block (77) is sleeved on the ball screw (75), and the syringe push piece (78) is coaxially arranged with the syringe (9) and is installed and connected with the front end of the sliding block (77).

9. The microfluidic technology-based nanomedicine production apparatus according to claim 8, wherein, The injector propelling module (7) further comprises a pressure sensor, a contact sensor (72), a drag chain (74) and a sensor sensing sheet (76); The pressure sensor is installed on the injector pusher (78) and used for monitoring the pressure of the injector pusher (78) when pushing the injector (9), one end of the drag chain (74) is connected with the rear end of the slider (77), the sensor sensing sheet (76) is installed on the side of the slider (77), and the contact sensor (72) is installed on the surface of the second mounting plate (792) corresponding to the position of the sensor sensing sheet (76).

10. The microfluidic technology-based nanodrug production apparatus according to claim 1, wherein, The main machine (1) further comprises a turnover door (2), the turnover door (2) is rotationally connected with the outer side wall of the main machine (1), and a containing cavity is defined between the main machine (1) and the turnover door (2). The chip clamp module (3), the micro-fluidic chip box (4), the heating module (5), the injector (9), the liquid receiving pipe (10) of the liquid receiving module (6) and the injector pusher (78) of the injector propelling module (7) are all located in the containing cavity.

11. The microfluidic technology-based nanomedicine production apparatus according to claim 10, wherein, The side wall of the containing cavity is composed of a first side wall, a second side wall and the arc-shaped side wall of the turnover door (2), a long strip-shaped through slot is formed in the first side wall, and a through hole is formed in the second side wall. The chip clamp module (3) and the heating module (5) are both installed on the first side wall, the moving end of the injector propelling module (7) extends into the interior of the containing cavity through the through slot, and the moving end of the liquid receiving module (6) extends into the interior of the containing cavity through the through hole.

12. The microfluidic technology-based nanomedicine production apparatus according to claim 1, wherein, The main machine (1) further comprises a man-machine interaction module (8), the man-machine interaction module (8) comprises a touch screen (81), a power-on / off button (82), an indicator light (83) and a mounting rack (84), the mounting rack (84) is installed on the main machine (1), the mounting rack (84) is provided with a mounting window, the touch screen (81) is installed in the mounting window of the mounting rack (84), and the power-on / off button (82) and the indicator light (83) are both installed on the mounting rack (84).

13. The microfluidic technology based nanomedicine production device according to claim 12, wherein, The touch screen (81) is rotationally connected with the mounting rack (84).

14. The microfluidic technology-based nanomedicine production device according to claim 12 or 13, characterized in that, The main machine (1) comprises a control unit, and the micro-fluidic chip box (4), the heating module (5), the liquid receiving module (6), the injector propelling module (7), the touch screen (81), the power-on / off button (82) and the indicator light (83) are all electrically connected with the control unit.

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