Pharmaceutical packaging composite film and preparation method thereof

Abstract

The present invention discloses a composite film for pharmaceutical packaging and a method for preparing the same. The composite film comprises a main body film, which comprises, from bottom to top, an inner layer, an intermediate layer, and an outer layer, which are bonded together. The intermediate layer is provided with chitosan microcapsules, and the surface of the intermediate layer is provided with an isolation layer and an antibacterial layer. The composite film can achieve a long-lasting antibacterial effect, providing antibacterial protection for a longer period of time, thereby extending the shelf life of the product.

Description

Technical Field

[0001] The invention belongs to the technical field of packaging films, and particularly relates to a pharmaceutical packaging composite film and a preparation method thereof. Background Art

[0002] Pharmaceutical packaging composite film is a multi-layer film, usually composed of layers of different materials to meet the special needs of pharmaceutical packaging. This composite structure can provide protection, barrier, waterproof, moisture-proof, anti-oxidation and other functions to ensure the stability and safety of drugs.

[0003] Chinese patent application number 2015210105368 discloses a composite film for pharmaceutical packaging. From the inside out, it comprises an EVA layer, an EVOH layer, an EVA layer, a sterilizing layer, an EVA layer, a PTFE layer, an EVA layer, a PVC layer, an EVA layer, and an EVOH layer. The EVA layer exhibits excellent adhesive properties and, being solvent-free, is environmentally friendly and highly safe. The EVOH layer offers excellent gas barrier properties and excellent processability, limiting and increasing the isolation of oxygen and water vapor from the air, enhancing the protection of the contents within the film. The PTFE layer is also heat-resistant and flame-retardant, enhancing its fire resistance. The sterilizing layer exhibits excellent sterilization properties. The PVC layer is non-flammable, high-strength, weather-resistant, and possesses excellent geometric stability, protecting the inner film layers.

[0004] The pharmaceutical packaging composite film in the above solution has a sterilization effect through the sterilization layer during sterilization. However, the sterilization layer in the above solution is a coating made of nanosilver, which will age after a period of time and the sterilization effect does not last long. Summary of the Invention

[0005] To solve the above problems, the present invention provides a pharmaceutical packaging composite film, including a main film, wherein the main film includes an inner layer, an intermediate layer and an outer layer from bottom to top, the inner layer, the intermediate layer and the outer layer are bonded together from top to bottom, chitosan microcapsules are provided in the intermediate layer, and an isolation layer and an antibacterial layer are provided on the surface of the intermediate layer.

[0006] Preferably, the isolation layer is an aluminum foil layer, and the antibacterial layer is a silicon dioxide coating.

[0007] A method for preparing a composite film for pharmaceutical packaging comprises the following steps:

[0008] S1, prepare materials, prepare 100 parts by mass of polypropylene polymer as inner layer raw material, 80 parts by mass of polypropylene copolymer and 20 parts by mass of chitosan microcapsules as middle layer raw materials, and 100 parts by mass of polypropylene as outer layer raw material;

[0009] S2, melt extrusion, adding the above materials into the extruder in order, and extruding them after melting to obtain the inner layer, the middle layer and the outer layer;

[0010] S3 adds a functional layer, coating an aluminum foil layer on the surface of the middle layer, and then coating a silicon dioxide layer on the aluminum foil layer

[0011] S4, main film lamination, using a film laminating machine to laminate the inner layer, middle layer and outer layer together by hot pressing;

[0012] S5, roll cutting, roll the treated film into a roll and cut it into required sizes.

[0013] Preferably, the preparation method of chitosan microcapsules in step S1 is:

[0014] A. Prepare an antibacterial solution by adding 20 parts by mass of an antibacterial agent and 5 parts by mass of an organic solvent, stirring until fully dissolved;

[0015] B. Prepare chitosan solution by adding 50 parts by mass of chitosan and 10 parts by mass of organic solvent, and stir until a uniform chitosan solution is formed;

[0016] C. Emulsification: drop the antibacterial solution into the chitosan solution while stirring continuously to form an emulsion. While stirring, add 5 parts by mass of emulsifier to maintain uniform dispersion;

[0017] D. Curing: Add 10 parts by mass of a hardener to the formed microcapsule emulsion to promote chitosan cross-linking, and then stir evenly to ensure sufficient cross-linking reaction;

[0018] E. Precipitation and washing: placing the formed microcapsule emulsion into water to precipitate the microcapsules, and washing the microcapsules with water several times to remove unreacted solvent and other impurities;

[0019] F. Drying: Dry the washed microcapsules under appropriate conditions to obtain the final chitosan microcapsules.

[0020] Preferably, the film laminating machine described in step S3 includes a feeding device, a laminating device and a scraping device arranged along the production line, the feeding device includes a support frame, a driving support and a driven support are respectively connected to both sides of the support frame, a feeding roller shaft is rotatably provided between the driving support and the driven support, the driving support is connected to a driving device, and the driving device drives the feeding roller to rotate, the driven support includes a fixed part, a flipping part and a flipping part, one end of the fixed part is fixedly connected to the side wall of the support frame, the other end of the fixed part is hinged with a flipping part, the end of the flipping part away from the fixed part is hinged with a flipping part, the flipping part can be flipped horizontally, and the flipping part can be flipped vertically, the end of the flipping part close to one end of the flipping part is provided with a first shaft groove, the flipping part is provided with a second shaft groove, a bearing is provided between the first shaft groove and the second shaft groove, and a locking device is provided at the top of the first shaft groove and the second shaft groove.

[0021] Preferably, the locking device includes a locking bolt, a locking plug-in, a first bolt hole provided on the folding part, and a second bolt hole provided in the flipping part. The flipping part is also provided with a locking cavity connected to the second bolt hole. A socket through the outside is provided above the locking cavity. The locking bolt passes through the first bolt hole and the second bolt in sequence and enters the locking cavity. The locking plug-in is inserted into the locking cavity from the socket.

[0022] Preferably, the diameter of the locking plug gradually decreases from the head to the tail.

[0023] Preferably, the composite device comprises a first composite roller and a second composite roller which are sequentially arranged up and down, and the distance between the first composite roller and the second composite roller is smaller than the total thickness of the inner layer, the middle layer and the outer layer.

[0024] Preferably, the scraping device includes a first bracket and a second bracket which are symmetrically arranged on the left and right, the bottom of the first bracket and the second bracket are rotatably connected to guide rollers, the top of the first bracket is connected to a first lifting cylinder, the top of the second bracket is connected to a second lifting cylinder, the output end of the first lifting cylinder is connected to a first sliding block, a scraping roller is rotatably connected between the first sliding block and the second sliding block, a scraping groove is provided in the axial direction of the scraping roller, and a rotation limiting mechanism is connected to the side of the scraping roller.

[0025] Preferably, the rotation limiting mechanism includes a connecting plate arranged on the second sliding block, a first connecting block and a second connecting block are provided on both sides of the top of the connecting plate, a worm is provided for rotation between the first connecting block and the second connecting block, the end of the worm passes through the second connecting block and is connected to a turntable, the neck of the scraping roller is connected to a worm wheel, and the worm wheel is engaged with the worm.

[0026] The advantages of the present invention are:

[0027] 1. This solution incorporates chitosan microcapsules within the main membrane, using microencapsulation technology to encapsulate the antimicrobial agent. The enclosed structure of the microcapsules controls the release rate of the antimicrobial agent, allowing for a slow release. This slow release method achieves a long-lasting antimicrobial effect. Compared to directly adding an antimicrobial membrane, this slower release rate provides longer-term antimicrobial protection, helping to extend the product's shelf life.

[0028] 2. In this solution, the main film is also equipped with an isolation layer and an antibacterial layer. The isolation layer isolates light, oxygen, and moisture, protecting the drug from the external environment, while the antibacterial layer helps absorb and retain moisture, thereby reducing humidity on the film surface. Under low humidity conditions, the growth rate of bacteria and fungi is slowed, enhancing the antibacterial effect.

[0029] 3. The driven support in this solution can be quickly disassembled, which can reduce installation time and improve convenience when adding new membranes to be composited.

[0030] 4. The locking device in this solution can improve the tightness of the bolt connection, prevent loosening, and ensure the stability of the feed roller shaft during rotation.

[0031] 5. The scraping roller in this solution can adjust the height according to the needs, and scrape the surface of the composite rollers of different diameters to ensure the cleanliness of the composite roller surface. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 This is a structural diagram of the composite membrane of the present invention.

[0033] Figure 2 Flow chart of the method of the present invention.

[0034] Figure 3 This is a structural diagram of the film laminating machine of the present invention.

[0035] Figure 4 It is the structural diagram of the feeding device of the present invention.

[0036] Figure 5 This is a structural diagram of the driven support of the present invention.

[0037] Figure 6 This is a structural diagram of the locking device of the present invention without a locking plug-in.

[0038] Figure 7 This is a diagram of the locking plug-in of the present invention.

[0039] Figure 8 It is a structural diagram of the scraping device of the present invention.

[0040] Figure 9 This is a structural diagram of the rotation limiting mechanism of the present invention.

[0041] In the figure: 1 inner layer, 2 middle layer, 3 outer layer, 4 isolation layer, 5 antibacterial layer, 6 support frame, 7 driving support, 8 driven support, 9 feed roller, 10 fixing part, 11 turning part, 12 turning part, 13 first shaft groove, 14 second shaft groove, 15 bearing, 16 locking bolt, 17 locking plug-in, 18 first bolt hole, 19 second bolt hole, 20 locking cavity, 21 jack, 22 first composite roller, 23 second composite roller, 24 first bracket, 25 second bracket, 26 first lifting cylinder, 27 second lifting cylinder, 28 first sliding block, 29 second sliding block, 30 connecting plate, 31 first connecting block, 32 second connecting block, 33 worm, 34 turntable, 35 worm gear, 36 scraping roller. DETAILED DESCRIPTION

[0042] The technical solutions in the embodiments of the present invention will be described clearly and completely below with reference to the accompanying drawings in the embodiments of the present invention. Example 1

[0043] like Figure 1 As shown, a composite film for pharmaceutical packaging comprises a main body film and functional layers. The main body film comprises, from bottom to top, an inner layer 1, an intermediate layer 2, and an outer layer 3. The inner layer 1, intermediate layer 2, and outer layer 3 are bonded together vertically, and the intermediate layer 2 is provided with chitosan microcapsules. In this embodiment, both the inner layer 1 and the outer layer 3 are composed of polypropylene. This material has the advantages of being transparent, wear-resistant, and chemically stable. Polypropylene is also harmless to pharmaceuticals and odorless, and has good sealing and processability. The intermediate layer 2 is primarily made of a polypropylene copolymer, which is produced by copolymerizing propylene with other monomers introduced during the polymerization process. These other monomers can be acrylic acid, acrylic esters, etc. The introduction of the copolymer can modify the properties of the polymer, improving its flexibility and impact resistance. Chitosan microcapsules are provided in the middle layer 2. The chitosan microcapsules are microcapsule structures formed with chitosan as the wall material and thymol as the antibacterial agent. After the chitosan microcapsules are embedded in the middle layer 2, during the packaging process, the microcapsules will gradually release the antibacterial agent over time to achieve a lasting antibacterial effect, which can provide antibacterial protection for a longer period of time and help extend the shelf life of the product.

[0044] The surface of the intermediate layer 2 is provided with an isolation layer 4 and an antibacterial layer 5. The isolation layer 4 is an aluminum foil layer, and the antibacterial layer 5 is a silica coating. The aluminum foil layer isolates light, oxygen, and moisture, protecting the drug from the external environment, while the silica coating helps absorb and retain moisture, thereby reducing humidity on the film surface. Under low humidity conditions, the growth rate of bacteria and fungi is slowed, enhancing the antibacterial effect. Example 2

[0045] Combine Figure 2, a method for preparing a composite film for pharmaceutical packaging, comprising the following steps;

[0046] S1, prepare materials, prepare 100 parts by mass of polypropylene polymer as the raw material of inner layer 1, 80 parts by mass of polypropylene copolymer and 20 parts by mass of chitosan microcapsules as the raw material of middle layer 2, and 100 parts by mass of polypropylene as the raw material of outer layer 3;

[0047] S2, melt extrusion, adding the above materials into the extruder in order, and extruding after melting to obtain inner layer 1, middle layer 2 and outer layer 3;

[0048] S3 adds a functional layer, coating an aluminum foil layer on the surface of the intermediate layer 2, and then coating a silicon dioxide layer on the aluminum foil layer

[0049] S4, main film lamination, using a film laminating machine to laminate the inner layer 1, the middle layer 2 and the outer layer 3 together by hot pressing;

[0050] S5, roll cutting, roll the treated film into a roll and cut it into required sizes.

[0051] The preparation method of chitosan microcapsules in step S1 is:

[0052] A. Prepare an antibacterial solution by adding 20 parts by mass of an antibacterial agent and 5 parts by mass of an organic solvent, stirring until fully dissolved;

[0053] B. Prepare chitosan solution by adding 50 parts by mass of chitosan and 10 parts by mass of organic solvent, and stir until a uniform chitosan solution is formed;

[0054] C. Emulsification: drop the antibacterial solution into the chitosan solution while stirring continuously to form an emulsion. While stirring, add 5 parts by mass of emulsifier to maintain uniform dispersion;

[0055] D. Curing: Add 10 parts by mass of a hardener to the formed microcapsule emulsion to promote chitosan cross-linking, and then stir evenly to ensure sufficient cross-linking reaction;

[0056] E. Precipitation and washing: placing the formed microcapsule emulsion into water to precipitate the microcapsules, and washing the microcapsules with water several times to remove unreacted solvent and other impurities;

[0057] F. Drying: Dry the washed microcapsules under appropriate conditions to obtain the final chitosan microcapsules.

[0058] The final chitosan microcapsules are gradually added to the middle layer 2, ensuring that they are evenly dispersed throughout the raw materials of the middle layer 2. The middle layer 2 is then extruded and composited with the outer layer 3 and inner layer 1. The enclosed structure of the microcapsules allows for controlled, slow release of the antimicrobial agent. This slow release method provides a long-lasting antimicrobial effect, providing a slower release rate than directly adding an antimicrobial film, and thus providing antimicrobial protection for a longer period of time.

[0059] The bacterial inhibition rates of the pharmaceutical packaging composite film produced in this embodiment and the traditional packaging film are shown in Table 1.

[0060] The microbial contamination of the pharmaceutical packaging composite film produced in this example and the traditional packaging film products are shown in Table 2.

[0061] It can be seen from Table 1 and Table 2 that the antibacterial effect of this embodiment is far superior to that of traditional packaging films. Example 3

[0062] like Figure 3-9 As shown, during compounding, the film compounding machine in this embodiment includes a feeding device, a compounding device and a scraping device arranged along the production line, combined with Figure 4 The feeding device includes a support frame 6, and the two sides of the support frame 6 are respectively connected to a driving support 7 and a driven support 8. A feeding roller shaft 9 is provided between the driving support 7 and the driven support 8. A driving device is connected to the driving support 7, and the driving device drives the feeding roller to rotate. Figure 5 The driven support 8 includes a fixed portion 10, a flip portion 11 and a closing portion 12. One end of the fixed portion 10 is fixedly connected to the side wall of the support frame 6, and the other end of the fixed portion 10 is hinged with the flip portion 11. The end of the flip portion 11 away from the fixed portion 10 is hinged with the closing portion 12. The flip portion 11 can be flipped horizontally, and the closing portion 12 can be flipped vertically. A first axis groove 13 is provided at the end of the flip portion 11 close to one end of the closing portion 12, and a second axis groove 14 is provided on the closing portion 12. A locking device is connected between the first axis groove 13 and the second axis groove 14.

[0063] Combine Figure 3 The extruded outer layer 3, middle layer 2 and inner layer 1 are wound into a cylindrical shape and placed on three feeding devices respectively. Then, the outer layer 3, middle layer 2 and inner layer 1 are continuously transported to the compounding device by the feeding device for compounding. Finally, the surface of the compounded main film is kept flat by the scraping device before cutting. In this embodiment, the feeding roller 9 is responsible for supporting the corresponding wound outer layer 3, middle layer 2 and inner layer 1 and assisting their rotation and transportation. Figure 5In order to facilitate the installation of the corresponding outer layer 3, the middle layer 2 and the inner layer 1, the driven support 8 in this embodiment can be flipped. When a new wound outer layer 3 needs to be installed, the locking device is first opened to separate the flap 12 from the flip part 11. At this time, the flap 12 is flipped in the vertical direction to separate the first shaft groove 13 and the second shaft groove 14. At this time, the bearing 15 between the first shaft groove 13 and the second shaft groove 14 can be removed along the end of the feed roller 9. At this time, the second shaft groove 14 on the flap 12 will be at a large distance from the feed roller 9, which can facilitate the horizontal rotation of the flap 12. After the flap 12 rotates horizontally, the end space of the feed roller 9 will no longer be restricted. At this time, the newly wound outer layer 3 can be placed on the feed roller 9, so that the outer layer 3 can be installed quickly, accelerating the composite rate of the new main body film.

[0064] Combine Figure 6-7The locking device includes a locking bolt 16, a locking plug-in 17, a first bolt hole 18 provided on the flip portion 12, and a second bolt hole 19 provided in the flip portion 11. The flip portion 11 is also provided with a locking cavity 20 connected to the second bolt hole 19. A socket 21 that passes through the outside is provided above the locking cavity 20. The locking bolt 16 passes through the first bolt hole 18 and the second bolt in sequence and enters the locking cavity 20. The locking plug-in 17 is inserted into the locking cavity 20 from the socket 21. In this embodiment, the folding portion 12 and the flipping portion 11 are fixed by a locking bolt 16. After the newly wound outer layer 3 is installed, the bearing 15 is first sleeved on the end of the feed roller shaft 9, and then the flipping portion 11 and the folding portion 12 are rotated again to recombine the first shaft groove 13 and the second shaft groove 14 to support the bearing 15. Then, the locking bolt 16 is inserted into the first bolt hole 18 and the second bolt hole 19 to complete the preliminary fixation. After that, the locking plug-in 17 is inserted into the socket 21. The locking plug-in 17 can be made of a metal material such as iron or copper to form a rod with a smaller diameter, similar to a thicker iron wire or copper wire. This rod is not easy to break and is easy to deform. When locking insert 17 is inserted into locking cavity 20, the surface of locking cavity 20 is unthreaded, unlike second bolt hole 19. Instead, the space between the sidewalls of locking cavity 20 and the threads on the surface of locking bolt 16 forms a threaded space. Inserted into locking cavity 20, locking insert 17 contacts the thread groove on the surface of locking bolt 16 and then moves along the groove, forming a spiral. The diameter of locking insert 17 gradually decreases from head to tail, and from the tail, locking insert 17 gradually inserts into the threaded space. Its head is shaped like a handle, facilitating removal and insertion. Because the diameter of locking insert 17 gradually increases from tail to head, it gradually becomes stuck. Once stuck, locking bolt 16 is locked by locking insert 17, preventing it from moving. Therefore, even if the equipment vibrates, locking bolt 16 will not loosen. This locking device effectively ensures the stability of the connection of locking bolt 16.

[0065] Combine Figure 8-9 The composite device includes a first composite roller 22 and a second composite roller 23 arranged in sequence up and down. The distance between the first composite roller 22 and the second composite roller 23 is less than the sum of the thicknesses of the inner layer 1, the middle layer 2 and the outer layer 3. When the inner layer 1, the middle layer 2 and the outer layer 3 pass through the first composite roller 22 and the second composite roller 23 together, they are formed into a composite film by rolling.

[0066] Scraping devices are installed on both the upper and lower sides of the composite device to remove or scrape excess material from the surface of the composite roller, such as liquids, pastes, or other materials coated on the roller shaft. The scraping device includes a first bracket 24 and a second bracket 25, which are symmetrically arranged on both sides. The bottoms of the first bracket 24 and the second bracket 25 are rotatably connected to guide rollers. The top of the first bracket 24 is connected to a first lifting cylinder 26, and the top of the second bracket 25 is connected to a second lifting cylinder 27. The output end of the first lifting cylinder 26 is connected to a first sliding block 28. A scraping roller 36 is rotatably connected between the first sliding block 28 and the second sliding block 29. The scraping roller 36 has a scraping groove on its axial direction, and a rotation limit mechanism is connected to the side of the scraping roller 36. After the composite roller completes the composite, its surface needs to be cleaned. In this embodiment, taking the first composite roller 22 above as an example, the first lifting cylinder 26 and the second lifting cylinder 27 are used to drive the scraping roller 36 to gradually approach the first composite roller 22, and the scraping groove directly contacts the surface of the first composite roller 22. Then, the composite roller is driven to rotate by the driving device, and the scraping groove on the scraping roller 36 continuously scrapes the rubber material on the surface of the first composite roller 22 to ensure the cleanliness of the surface of the first composite roller 22.

[0067] The rotation limiting mechanism includes a connecting plate 30 mounted on the second sliding block 29. A first connecting block 31 and a second connecting block 32 are located on either side of the connecting plate 30. A worm 33 rotates between the first connecting block 31 and the second connecting block 32. The end of the worm 33 passes through the second connecting block 32 and is connected to a turntable 34. A worm gear 35 is connected to the neck of a scraping roller 36, which meshes with the worm 33. Each scraping roller 36 has at least two scraping grooves. When enough scraper material accumulates in the first scraping groove, the turntable 34 rotates, driving the worm gear 35 and worm 33, causing the scraping roller 36 to rotate. The scraping groove on the other side of the scraping roller 36 moves to the surface of the first composite roller 22, cleaning the surface of the first composite roller 22 and simultaneously cleaning the scraping grooves where waste material has accumulated. This allows for rapid and continuous cleaning of the surface of the first composite roller 22, improving the cleaning rate. The worm gear 35 and worm 33 prevent the scraping roller 36 from rotating on its own; it rotates only when the worm 33 is engaged.

[0068] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A method for preparing a composite film for pharmaceutical packaging, characterized in that: The following steps are included: S1, prepare materials, prepare 100 parts by mass of polypropylene polymer as the raw material of the inner layer (1), 80 parts by mass of polypropylene copolymer and 20 parts by mass of chitosan microcapsules as the raw materials of the middle layer (2), and 100 parts by mass of polypropylene as the raw material of the outer layer (3); S2, melt extrusion, adding the above materials into the extruder in order, and extruding them after melting to obtain the inner layer (1), the middle layer (2) and the outer layer (3); S3 adds a functional layer, coating an aluminum foil layer on the surface of the middle layer (2), and then coating a silicon dioxide layer on the aluminum foil layer S4, main film lamination, using a film laminating machine to laminate the inner layer (1), the middle layer (2) and the outer layer (3) together by hot pressing; S5, roll cutting, roll the treated film into a roll and cut it into the required size; The film laminating machine described in step S3 includes a feeding device and a laminating device arranged along the production line, the feeding device includes a support frame (6), the two sides of the support frame (6) are respectively connected to a driving support (7) and a driven support (8), a feeding roller shaft (9) is rotatably provided between the driving support (7) and the driven support (8), the driving support (7) is connected to the driving device, the driving device drives the feeding roller to rotate, the driven support (8) includes a fixing part (10), a turning part (11) and a folding part (12), one end of the fixing part (10) is fixedly connected to the side wall of the support frame (6), and the The other end of the fixed portion (10) is hingedly connected to a flip portion (11), and the flip portion (11) is hingedly connected to a folding portion (12) at one end away from the fixed portion (10). The flip portion (11) can be flipped in a horizontal state, and the folding portion (12) can be flipped in a vertical state. A first shaft groove (13) is provided at an end of the flip portion (11) close to one end of the folding portion (12), and a second shaft groove (14) is provided on the folding portion (12). A bearing (15) is provided between the first shaft groove (13) and the second shaft groove (14), and a locking device is provided at the top of the first shaft groove (13) and the second shaft groove (14).

2. The method for preparing the pharmaceutical packaging composite film according to claim 1, wherein: The locking device comprises a locking bolt (16), a locking plug-in (17), a first bolt hole (18) provided on the folding portion (12), and a second bolt hole (19) provided in the flipping portion (11); the flipping portion (11) is further provided with a locking cavity (20) communicating with the second bolt hole (19); an insertion hole (21) penetrating the outside is provided above the locking cavity (20); the locking bolt (16) passes through the first bolt hole (18) and the second bolt hole (18) in sequence and enters the locking cavity (20); and the locking plug-in (17) is inserted into the locking cavity (20) from the insertion hole (21).

3. The method for preparing the pharmaceutical packaging composite film according to claim 2, wherein: The diameter of the locking plug-in (17) gradually decreases from the head to the tail.

4. The method for preparing the pharmaceutical packaging composite film according to claim 3, wherein: The composite device comprises a first composite roller (22) and a second composite roller (23) which are arranged in sequence above and below each other, wherein the distance between the first composite roller (22) and the second composite roller (23) is smaller than the total thickness of the inner layer (1), the middle layer (2) and the outer layer (3).

5. The method for preparing the pharmaceutical packaging composite film according to claim 4, wherein: A scraping device is provided on both the upper and lower sides of the composite device, and the scraping device includes a first bracket (24) and a second bracket (25) which are symmetrically arranged on the left and right sides. The top of the first bracket (24) is connected to a first lifting cylinder (26), and the top of the second bracket (25) is connected to a second lifting cylinder (27). The output end of the first lifting cylinder (26) is connected to a first sliding block (28). A scraping roller (36) is rotatably connected between the first sliding block (28) and the second sliding block (29). A scraping groove is provided in the axial direction of the scraping roller (36), and a rotation limiting mechanism is connected to the side of the scraping roller (36).

6. The method for preparing the pharmaceutical packaging composite film according to claim 5, wherein: The rotation limiting mechanism includes a connecting plate (30) provided on the second sliding block (29), a first connecting block (31) and a second connecting block (32) are provided on both sides of the top of the connecting plate (30), a worm (33) is provided between the first connecting block (31) and the second connecting block (32), the end of the worm (33) passes through the second connecting block (32) and is connected to a turntable (34), the neck of the scraping roller (36) is connected to a worm wheel (35), and the worm wheel (35) is engaged with the worm (33).

Images