A method for purifying zirconium-89 to reduce the amount of ionizing radiation exposure to personnel

Abstract

The present application relates to the field of ionizing radiation, in particular to a method for purifying Zr-89 for reducing the ionizing radiation exposure of personnel, which comprises the following steps: preparing materials, preparing instruments, pretreating materials, dissolving the materials, and performing secondary treatment on the product after reaction to achieve the effect of purification. Meanwhile, the process can be performed by mechanical equipment and a computer connected to the equipment for control, so as to reduce the ionizing radiation exposure of the operator, achieve sufficient shielding, ensure the safety of the personnel, efficiently complete the purification of Zr-89, and effectively control the extraction and addition of reagents by using a syringe with precise control, so as to ensure the success of the test and provide an isolation effect.

Description

Technical Field

[0001] This invention relates to the field of ionizing radiation, and more specifically to a purification method for reducing the amount of ionizing radiation exposure to personnel using Zr-89. Background Technology

[0002] Zirconium-89 (Zr-89) is a positron-emitting nuclide commonly used in the development of positron emission tomography (PET) radiopharmaceuticals. Zr-89 possesses favorable physical properties (T... 1 / 2 Zr-89 (78.4h) is commonly used for labeling monoclonal antibodies. It decays into the intermediate isotope Y-89m through 22.3% positron emission and 76.6% electron capture, followed by immediate decay into the stable isotope Y-89. Zr-89 is typically prepared by irradiating a Y-89 target sheet and then purifying and isolating it from the target sheet. With Zr-89-labeled immunoPET imaging probes becoming increasingly popular, the demand for this isotope is also gradually rising.

[0003] However, Zr-89 emits high-energy gamma photons (511 keV and 909 keV), which could expose personnel to high radiation doses. From a radiation safety perspective, direct operation during purification has a low safety factor and is prone to radioactive contamination, making it difficult to implement.

[0004] Therefore, there is a need to develop a method that can isolate the Zr-89 purification process to reduce the amount of ionizing radiation exposure to operators. Summary of the Invention

[0005] The purpose of this invention is to overcome the above-mentioned defects and provide a purification method for Zr-89 that reduces the amount of ionizing radiation exposure to personnel.

[0006] The objective of this invention is achieved through the following method: a purification method for Zr-89 that reduces ionizing radiation exposure to personnel, the method comprising the following steps:

[0007] A: Prepare the following materials: 12.0M hydrochloric acid, 2.0M hydrochloric acid, 0.05M oxalic acid, a target sheet containing Zr-89 after irradiation, and distilled water.

[0008] B: Prepare the instruments, namely purification device, sterile bottle, polytetrafluoroethylene tube, syringe, reactor, dissolution tank, purification column, peristaltic pump I, peristaltic pump II, six-way valve, waste liquid bottle and product bottle;

[0009] C: Connect the syringe, reactor, dissolution tank, purification column, peristaltic pump I, and peristaltic pump II to the purification device; add 12.0M hydrochloric acid, 2.0M hydrochloric acid, 0.05M oxalic acid, and distilled water to sterile bottles respectively, and connect them to the syringes via PTFE tubing and six-way valves; connect the waste bottle and product bottle to the purification column outlet via PTFE tubing and six-way valves respectively.

[0010] D: Use a syringe to draw 10 ml of distilled water and 3 ml of 2.0 M hydrochloric acid to pretreat the purification column;

[0011] E: Place the target in the dissolution tank, draw 6 ml of 12M hydrochloric acid into the reactor using a syringe, and use peristaltic pump I to circulate it between the reactor and the dissolution tank to dissolve the target in the dissolution tank for 20 minutes. Then draw 4 ml of 2M hydrochloric acid into the reactor using a syringe and continue to circulate and dissolve for 20 minutes.

[0012] F: After dissolution, the mixture of 12M hydrochloric acid and 2M hydrochloric acid obtained in step E is pumped back into the reactor using peristaltic pump I, and then added to the purification column using peristaltic pump II, so that it passes through the purification column and is discharged into the waste bottle at the same time.

[0013] G: Draw 10 ml of 2M hydrochloric acid into the reactor using a syringe, and use peristaltic pump I to circulate the 2M hydrochloric acid between the reactor and the dissolution tank for 3 minutes to clean the reactor and the dissolution tank.

[0014] H: After the cycle cleaning is completed, the cleaned 2M hydrochloric acid is pumped back into the reactor using peristaltic pump I, and then added to the purification column using peristaltic pump II, so that it passes through the purification column and is discharged into the waste bottle at the same time.

[0015] I: Draw 30 ml of water into a syringe to rinse the purification column, allowing it to pass through the purification column and be discharged into the waste bottle at the same time;

[0016] J: Draw 4 ml of 0.05 M oxalic acid into the purification column using a syringe, and rinse Zr-89 into the product bottle.

[0017] Furthermore, the main component of the target in A is yttrium, and the target contains approximately 1800 mg.

[0018] Furthermore, the type of reagent drawn by the syringe in B is controlled by a six-way valve.

[0019] Furthermore, the destination of the liquid flowing out of the purification column in B is controlled by a six-way valve.

[0020] Furthermore, the purification device in B is a computer-controlled device, and all processes are controlled by the computer connected to the purification device.

[0021] The beneficial effects of this invention are as follows: Different metal ions have different adsorption capacities on the purification column under different acidity conditions. The addition of hydrochloric acid and oxalic acid achieves the purification effect. At the same time, the process can be carried out by mechanical equipment and a computer connected to the control equipment, achieving sufficient shielding, reducing the amount of ionizing radiation exposure to the operators, ensuring personnel safety, and efficiently completing the purification of Zr-89. Attached Figure Description

[0022] Figure 1 This is a schematic diagram illustrating the connection of a purification method for Zr-89 to reduce ionizing radiation exposure to personnel according to the present invention.

[0023] In the diagram: 1-Waste liquid bottle, 2-Reaction reagents (hydrochloric acid, oxalic acid, distilled water), 3-Instrument, 4-Reactor, 5-Dissolving tank, 6-Purification column, 7-Product bottle, 8-Target plate, 9-Peristaltic pump I, 10-Peristaltic pump II, 11-Six-way valve. Detailed Implementation

[0024] To facilitate understanding by those skilled in the art, the present invention will be further described below with reference to embodiments. The content mentioned in the embodiments is not intended to limit the present invention.

[0025] The specific implementation of this method is a purification method for Zr-89 that reduces ionizing radiation exposure to personnel. This method includes the following steps:

[0026] A: Prepare the following materials: 12.0M hydrochloric acid, 2.0M hydrochloric acid, 0.05M oxalic acid, a target sheet containing Zr-89 after irradiation, and distilled water.

[0027] B: Prepare the instruments, namely purification device, sterile bottle, polytetrafluoroethylene tube, syringe, reactor, dissolution tank, purification column, peristaltic pump I, peristaltic pump II, six-way valve, waste liquid bottle and product bottle;

[0028] C: Connect the syringe, reactor, dissolution tank, purification column, peristaltic pump I, and peristaltic pump II to the purification device; add 12.0M hydrochloric acid, 2.0M hydrochloric acid, 0.05M oxalic acid, and distilled water to sterile bottles respectively, and connect them to the syringes via PTFE tubing and six-way valves; connect the waste bottle and product bottle to the purification column outlet via PTFE tubing and six-way valves respectively.

[0029] D: Use a syringe to draw 10 ml of distilled water and 3 ml of 2.0 M hydrochloric acid to pretreat the purification column;

[0030] E: Place the target in the dissolution tank, draw 6 ml of 12M hydrochloric acid into the reactor using a syringe, and use peristaltic pump I to circulate it between the reactor and the dissolution tank to dissolve the target in the dissolution tank for 20 minutes. Then draw 4 ml of 2M hydrochloric acid into the reactor using a syringe and continue to circulate and dissolve for 20 minutes.

[0031] F: After dissolution, the mixture of 12M hydrochloric acid and 2M hydrochloric acid obtained in step E is pumped back into the reactor using peristaltic pump I, and then added to the purification column using peristaltic pump II, so that it passes through the purification column and is discharged into the waste bottle at the same time.

[0032] G: Draw 10 ml of 2M hydrochloric acid into the reactor using a syringe, and use peristaltic pump I to circulate the 2M hydrochloric acid between the reactor and the dissolution tank for 3 minutes to clean the reactor and the dissolution tank.

[0033] H: After the cycle cleaning is completed, the cleaned 2M hydrochloric acid is pumped back into the reactor using peristaltic pump I, and then added to the purification column using peristaltic pump II, so that it passes through the purification column and is discharged into the waste bottle at the same time.

[0034] I: Draw 30 ml of water into a syringe to rinse the purification column, allowing it to pass through the purification column and be discharged into the waste bottle at the same time;

[0035] J: Draw 4 ml of 0.05 M oxalic acid into the purification column using a syringe, and rinse Zr-89 into the product bottle.

[0036] The main component of the target tablet in A is yttrium, and the tablet contains approximately 1800 mg.

[0037] The type of reagent drawn by the syringe in section B is controlled by a six-way valve.

[0038] The destination of the liquid flowing out of the purification column in section B is controlled by a six-way valve.

[0039] The purification device in section B is a computer-controlled device, and all processes are controlled by the computer connected to the purification device.

[0040] The beneficial effects of this invention are as follows: Different metal ions have different adsorption capacities on the purification column under different acidity conditions. The addition of hydrochloric acid and oxalic acid achieves the purification effect. At the same time, the process can be carried out by mechanical equipment and a computer connected to the control equipment, achieving sufficient shielding, reducing the amount of ionizing radiation exposure to the operators, ensuring personnel safety, and efficiently completing the purification of Zr-89.

[0041] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some changes or modifications to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes, and modifications made to the above embodiments based on the present invention without departing from the scope of the present invention are within the scope of the present invention.

Claims

1. A purification method for Zr-89 to reduce the ionizing radiation exposure of personnel, the method comprising the following steps: A: Prepare the following materials: 12.0M hydrochloric acid, 2.0M hydrochloric acid, 0.05M oxalic acid, a target sheet containing Zr-89 after irradiation, and distilled water. The target tablet contains yttrium metal and has a dosage of 1800 mg. B: Prepare the instruments, namely purification device, sterile bottle, polytetrafluoroethylene tube, syringe, reactor, dissolution tank, purification column, peristaltic pump I, peristaltic pump II, six-way valve, waste liquid bottle and product bottle; C: Connect the syringe, reactor, dissolution tank, purification column, peristaltic pump I, and peristaltic pump II to the purification device; add 12.0M hydrochloric acid, 2.0M hydrochloric acid, 0.05M oxalic acid, and distilled water to sterile bottles respectively, and connect them to the syringes via PTFE tubing and six-way valves; connect the waste bottle and product bottle to the purification column outlet via PTFE tubing and six-way valves respectively. D: Use a syringe to draw 10 ml of distilled water and 3 ml of 2.0 M hydrochloric acid to pretreat the purification column; E: Place the target in the dissolution tank, draw 6 ml of 12M hydrochloric acid into the reactor using a syringe, and use peristaltic pump I to circulate it between the reactor and the dissolution tank to dissolve the target in the dissolution tank for 20 minutes. Then draw 4 ml of 2M hydrochloric acid into the reactor using a syringe and continue to circulate and dissolve for 20 minutes. F: After dissolution, the mixture of 12M hydrochloric acid and 2M hydrochloric acid obtained in step E is pumped back into the reactor using peristaltic pump I, and then added to the purification column using peristaltic pump II, so that it passes through the purification column and is discharged into the waste bottle at the same time. G: Draw 10 ml of 2M hydrochloric acid into the reactor using a syringe, and use peristaltic pump I to circulate the 2M hydrochloric acid between the reactor and the dissolution tank for 3 minutes to clean the reactor and the dissolution tank. H: After the cycle cleaning is completed, the cleaned 2M hydrochloric acid is pumped back into the reactor using peristaltic pump I, and then added to the purification column using peristaltic pump II, so that it passes through the purification column and is discharged into the waste bottle at the same time. I: Draw 30 ml of water into a syringe to rinse the purification column, allowing it to pass through the purification column and be discharged into the waste bottle at the same time; J: Draw 4 ml of 0.05 M oxalic acid into the purification column using a syringe, and rinse Zr-89 into the product bottle.

2. The purification method for Zr-89 to reduce the ionizing radiation exposure of personnel according to claim 1, characterized in that: The type of reagent drawn by the syringe in section B is controlled by a six-way valve.

3. The purification method for Zr-89 to reduce the ionizing radiation exposure of personnel according to claim 1, characterized in that: The destination of the liquid flowing out of the purification column in section B is controlled by a six-way valve.

4. The Zr-89 purification method for reducing the ionizing radiation exposure of personnel according to claim 1, characterized in that: The purification device in B is a computer-controlled device, and all processes are controlled by operating the computer.

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