Sample analyzer and electrolyte detection module

Abstract

The application discloses a sample analyzer and an electrolyte detection module. The sample analyzer comprises the electrolyte detection module, a sample module and a sample adding module. The electrolyte detection module comprises a detection electrode, a containing device, a power device, a detection device and a pressure adjusting device. The detection electrode comprises a shell and a selective membrane. The shell has an electrode cavity and a detection flow channel. The electrode cavity contains an electrolyte solution. The selective membrane is connected to the shell and is arranged between the electrode cavity and the detection flow channel. The containing device is used for containing a to-be-detected liquid. The power device is used for providing a driving force for the to-be-detected liquid in the containing device to flow through the detection flow channel. The detection device is used for acquiring an electric potential when the liquid flowing through the detection flow channel. The pressure adjusting device is used for adjusting the air pressure value in the electrode cavity. When there is an air pressure difference on both sides of the selective membrane, the pressure adjusting device can adjust the air pressure value in the electrode cavity, thereby reducing the deformation of the selective membrane.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a sample analyzer and an electrolyte detection module. BACKGROUND

[0002] An electrolyte analyzer is a device for measuring the content of electrolytes in a sample such as serum or urine. An ion selective electrode (hereinafter referred to as "ISE electrode") is widely used as a core sensor of the electrolyte analyzer. The ISE electrode mainly consists of a shell, an ion selective membrane (hereinafter referred to as "selective membrane"), an internal electrolyte solution, and an electrode silver rod composed of silver or silver chloride. The shell has a detection channel. When the liquid to be measured passes through the detection channel, the selective membrane can respond selectively to specific ions. However, when the ion selective electrode operates in a low pressure environment, the selective membrane will invade the space in the flow channel due to the pressure difference, resulting in a decrease in the cross-sectional area of the flow channel and an increase in the flow resistance. This further leads to poor fluid flow in the detection channel, causing problems such as dilution liquid residue and sample residue, which affect the final detection results. SUMMARY

[0003] The present application aims to at least solve one of the technical problems existing in the prior art. To this end, the present application proposes a sample analyzer which can reduce the deformation of the selective membrane in a low pressure environment and improve the problem of liquid discharge obstruction.

[0004] The present application also proposes an electrolyte detection module.

[0005] According to the sample analyzer of the first embodiment of the present application, the sample analyzer comprises:

[0006] The electrolyte detection module comprises a detection electrode, a containing device, a power device, a detection device, and a pressure adjusting device. The detection electrode comprises a shell and a selective membrane. The shell has an electrode cavity and a detection flow channel. The electrode cavity contains an electrolyte solution. The selective membrane is connected to the shell and is arranged between the electrode cavity and the detection flow channel. The containing device is used to contain the liquid to be measured. The power device is used to provide a driving force for the liquid to be measured in the containing device to flow through the detection flow channel. The detection device is used to obtain the electric potential when the liquid flows through the detection flow channel. The pressure adjusting device is used to adjust the air pressure value in the electrode cavity.

[0007] The sample module is provided with at least one sample site for placing a sample container for containing the liquid to be measured.

[0008] The sample adding module comprises a moving device and a sample needle arranged on the moving device, the moving device is used to drive the sample needle to move between the sample site and the accommodating device, so as to draw the liquid to be tested at the sample site by the sample needle and discharge the liquid to be tested to the accommodating device.

[0009] According to the sample analyzer provided by the embodiment of the present application, at least the following beneficial effects are achieved:

[0010] The electrolyte detection module comprises a pressure adjusting device, when there is a pressure difference between two sides of the selective membrane, the pressure adjusting device can adjust the pressure value in the electrode cavity, so as to balance the pressure on both sides of the selective membrane, reduce or eliminate the deformation of the selective membrane, improve the problems of residual diluent and sample caused by the blockage of liquid discharge, and ensure the accuracy of the detection result.

[0011] In other embodiments of the present application, the pressure adjusting device comprises a volume adjusting assembly, the volume adjusting assembly adjusts the pressure value in the electrode cavity by adjusting the volume of the electrode cavity.

[0012] In other embodiments of the present application, the volume adjusting assembly comprises an adjusting component, the adjusting component is connected to the shell, at least partially extends into the electrode cavity, and can move relative to the shell to adjust the volume of the extending part.

[0013] In other embodiments of the present application, the volume adjusting assembly further comprises a sealing ring, the electrode cavity comprises a mounting hole arranged through the shell, a hole wall of the mounting hole comprises a connecting section and a sealing section arranged in the axial direction, the adjusting component comprises a connecting part and a sealing part arranged in the axial direction, the connecting part is threadedly connected with the connecting section, and the sealing ring is located between the sealing part and the sealing section.

[0014] In other embodiments of the present application, the volume adjusting assembly comprises an elastic membrane, the elastic membrane is connected to the shell and is used to separate the electrode cavity from the external environment, and the elastic modulus of the elastic membrane is smaller than the elastic modulus of the selective membrane.

[0015] In other embodiments of the present application, the pressure adjusting device comprises a gas-permeable membrane, the gas-permeable membrane is connected to the shell and is used to separate the electrode cavity from the external environment, and the gas-permeable membrane can make the gas flow from the high-pressure side to the low-pressure side.

[0016] In other embodiments of the present application, the shell has a vent hole, the pressure adjusting device comprises a plugging component, the plugging component is connected to the shell and closes the vent hole, and the plugging component can move relative to the shell to make the electrode cavity and the external environment communicate through the vent hole.

[0017] In other embodiments of the present application, the sample analyzer further comprises a controller configured to control the pressure adjusting device to adjust the air pressure value in the electrode cavity when the accommodation device has an abnormal liquid discharge.

[0018] In other embodiments of the present application, the electrolyte detection module further comprises a sensor assembly configured to detect a liquid level and / or a liquid discharge pressure in the accommodation device; and the abnormal liquid discharge of the accommodation device comprises at least one of:

[0019] the liquid level in the accommodation device is greater than or equal to a preset threshold after the liquid discharge of the accommodation device is completed;

[0020] the liquid discharge pressure is greater than or equal to a preset threshold during the liquid discharge of the accommodation device.

[0021] In other embodiments of the present application, the sample analyzer further comprises an air pressure detection device, and the controller is further configured to control the pressure adjusting device to adjust the air pressure value in the electrode cavity when the air pressure detection device detects that the ambient air pressure is less than a preset threshold.

[0022] According to the sample analyzer of the second embodiment of the present application, the sample analyzer comprises:

[0023] The electrolyte detection module comprises a detection electrode, an accommodation device, a power device, and a detection device. The detection electrode comprises a shell and a selective membrane. The shell has an electrode cavity and a detection flow channel. The electrode cavity contains an electrolyte solution. The detection flow channel comprises a first flow channel section and a second flow channel section. The selective membrane is connected to the shell and is arranged between the electrode cavity and the first flow channel section. The selective membrane is an elastic membrane. The initial cross-sectional area of the first flow channel section is greater than the cross-sectional area of the second flow channel section. The accommodation device is configured to accommodate a liquid to be tested. The power device is configured to provide a driving force for the liquid to be tested in the accommodation device to flow through the detection flow channel. The detection device is configured to obtain an electric potential when a liquid flows through the detection flow channel.

[0024] The sample module is provided with at least one sample site for placing a sample container for accommodating a liquid to be tested.

[0025] The sample module is provided with at least one sample site for placing a sample container for accommodating a liquid to be tested.

[0026] According to the sample analyzer of the embodiments of the present application, at least the following beneficial effects are achieved:

[0027] The cross-sectional area of the partial region of the detection flow channel is increased, and when the sample analyzer operates in a low-pressure environment, even if the selective membrane deforms into the detection flow channel, the first flow channel section can still maintain a certain cross-sectional area to ensure that the liquid can pass smoothly, thereby improving problems such as residual diluent and sample caused by blocked liquid discharge, and ensuring the accuracy of the detection result.

[0028] In other embodiments of the present application, the pipe wall of the first flow channel section is provided with a recess, and the recess is arranged on the opposite side of the selective membrane.

[0029] According to the sample analyzer of the third embodiment of the present application, comprising:

[0030] The electrolyte detection module comprises a detection electrode, a containing device, a power device, a detection device, and a limiting device. The detection electrode comprises a shell and a selective membrane. The shell has an electrode cavity and a detection flow channel. The electrode cavity contains an electrolyte solution. The selective membrane is connected to the shell and is arranged between the electrode cavity and the detection flow channel. The containing device is used to contain the liquid to be tested. The power device is used to provide a driving force for the liquid to be tested in the containing device to flow through the detection flow channel. The detection device is used to obtain the electric potential when the liquid flows through the detection flow channel. The limiting device can resist the selective membrane to limit the deformation of the selective membrane towards the detection flow channel. The limiting device has a liquid passing hole for the liquid to be tested to pass through.

[0031] The sample module is provided with at least one sample site for placing a sample container for containing the liquid to be tested.

[0032] The sample module is provided with at least one sample site for placing a sample container for containing the liquid to be tested.

[0033] According to the sample analyzer of the embodiment of the present application, at least the following beneficial effects are achieved:

[0034] The diameter of the entire detection flow channel is increased, and when the sample analyzer operates in a low-pressure environment, even if the selective membrane deforms into the detection flow channel, the detection flow channel can still maintain a certain cross-sectional area to ensure that the liquid can pass smoothly, thereby improving problems such as residual diluent and sample caused by blocked liquid discharge, and ensuring the accuracy of the detection result.

[0035] According to the sample analyzer of the fourth embodiment of the present application, comprising:

[0036] The electrolyte detection module comprises a detection electrode, a containing device, a power device and a detection device, the detection electrode comprises a shell and a selective membrane, the shell has an electrode cavity and a detection flow channel, the electrode cavity contains an electrolyte solution, the selective membrane is connected to the shell and is arranged between the electrode cavity and the detection flow channel, the diameter of the detection flow channel is 1.5mm to 2mm, the containing device is used for containing a to-be-tested liquid, the power device is used for providing a driving force for the to-be-tested liquid in the containing device to flow through the detection flow channel, and the detection device is used for acquiring an electric potential when the to-be-tested liquid flows through the detection flow channel.

[0037] The sample module is provided with at least one sample site used for placing a sample container used for containing a to-be-tested liquid.

[0038] The sample adding module comprises a moving device and a sample needle arranged on the moving device, the moving device is used for driving the sample needle to move between the sample site and the containing device, so as to suck the to-be-tested liquid at the sample site and discharge the to-be-tested liquid to the containing device through the sample needle.

[0039] The sample analyzer according to the embodiment of the present application has at least the following beneficial effects:

[0040] The electrolyte detection module comprises a limiting device, when there is a pressure difference on both sides of the selective membrane, the limiting device can resist the selective membrane to limit the deformation of the selective membrane towards the detection flow channel, thereby improving the problems of residual dilution liquid and sample caused by the blocked liquid discharge, and ensuring the accuracy of the detection result.

[0041] The electrolyte detection module according to the fifth embodiment of the present application comprises:

[0042] The detection electrode comprises a shell and a selective membrane, the shell has an electrode cavity and a detection flow channel, the electrode cavity contains an electrolyte solution, and the selective membrane is connected to the shell and arranged between the electrode cavity and the detection flow channel.

[0043] The containing device is used for containing a to-be-tested liquid.

[0044] The power device is used for providing a driving force for the to-be-tested liquid in the containing device to flow through the detection flow channel.

[0045] The detection device is used for acquiring an electric potential when the to-be-tested liquid flows through the detection flow channel.

[0046] The pressure adjusting device is used for adjusting the air pressure value in the electrode cavity.

[0047] Additional aspects and advantages of the present application will be given, partially in the following description, partially become obvious from the following description, or be understood by practice of the present application. BRIEF DESCRIPTION OF DRAWINGS

[0048] The present application will be further described with reference to the drawings and examples, wherein:

[0049] Figure 1 is a schematic diagram of a sample analyzer in a first embodiment of the present application;

[0050] Figure 2 is a schematic diagram of cooperation between a sample adding module and an electrolyte detecting module in the first embodiment of the present application;

[0051] Figure 3 is a perspective view of a detecting electrode when the sample analyzer in the first embodiment of the present application operates in a normal pressure environment;

[0052] Figure 4 is a schematic diagram of a detecting electrode when a sample analyzer in the related art operates in a normal pressure environment;

[0053] Figure 5 is a schematic diagram of a detecting electrode when a sample analyzer in the related art operates in a low pressure environment;

[0054] Figure 6 is a perspective view of a detecting electrode when a sample analyzer in another embodiment of the present application operates in a low pressure environment;

[0055] Figure 7 is a perspective view of a detecting electrode in yet another embodiment of the present application;

[0056] Figure 8 is a perspective view of a detecting electrode in yet another embodiment of the present application;

[0057] Figure 9 is a perspective view of a detecting electrode when a sample analyzer in yet another embodiment of the present application operates in a normal pressure environment;

[0058] Figure 10 is an exploded view of Figure 9

[0059] is a perspective view of a detecting electrode in yet another embodiment of the present application; Figure 11

[0060] is a perspective view of a detecting electrode in a second embodiment of the present application; Figure 12

[0061] is a perspective view of another detecting electrode in the second embodiment of the present application; Figure 13

[0062] ​Figure 14 A perspective view of the detection electrode in the fourth embodiment of the present application.

[0063] Reference signs:

[0064] Sample module 10;

[0065] Sample adding module 20, sample needle 21, moving device 22;

[0066] Electrolyte detection module 30, detection electrode 31, shell 311, electrode cavity 3111, detection flow channel 3112, connecting section 3113, sealing section 3114, air vent 3115, first sleeve 3116, second sleeve 3117, first flow channel section 3118, second flow channel section 3119, selective membrane 312, electrode stick 313, containing device 32, first power device 33, pressure adjusting device 34, adjusting component 341, connecting part 3411, sealing part 3412, sealing ring 342, elastic membrane 343, air permeable membrane 344, plugging component 345, sealing gasket 346, diluent container 35, second power device 36, control valve 37, degassing device 38, thermal stabilizing device 39, limiting device 310;

[0067] Sample container 40. DETAILED DESCRIPTION

[0068] Embodiments of the present application are described in detail below with reference to examples thereof illustrated in the accompanying drawings, wherein the same or like reference numerals represent the same or like elements throughout the drawings. The embodiments described below by reference to the drawings are exemplary only, and are merely intended to explain the present application, and should not be construed as limiting the present application.

[0069] In the description of the present application, it should be understood that the orientation description, such as the orientation or position relationship indicated by up, down, front, back, left, right, etc. is based on the orientation or position relationship shown in the drawings, and is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the present application.

[0070] In the description of the present application, if the meaning of several is more than one, the meaning of multiple is more than two, greater than, less than, more than, etc. is understood as not including the number, above, below, etc. is understood as including the number. If it is described as first, second, it is only for the purpose of distinguishing technical features, and should not be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated or the order of technical features indicated.

[0071] In the description of the present application, the words such as arrangement, installation, connection, etc. should be understood in a broad sense, and the specific meanings of the words in the present application can be determined by the person skilled in the art in combination with the specific content of the technical solutions.

[0072] In the description of the present application, the description of the terms "one embodiment", "some embodiments", "exemplary embodiment", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in combination with the embodiment or example are included in at least one embodiment or example of the present application. In the present specification, the exemplary description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0073] Referring to Figure 1 , Figure 2 , a plan view of a sample analyzer in a first embodiment of the present application is shown, and the arc-shaped dashed line in the figure represents the rotation trajectory of the rotating part. The sample analyzer in the embodiment of the present application includes a sample module 10, a sample adding module 20 and an electrolyte detection module 30, which will be described in detail in combination with the accompanying drawings.

[0074] The sample module 10 is used to carry the sample to be added. For example, the sample module 10 can be realized by a sample delivery module (SDM) and a front-end track. In some other embodiments, it can also be a rotary sample disc, and the sample disc is provided with at least one sample site for placing a sample container 40 such as a sample tube. The rotation of the sample disc can dispatch the sample to the corresponding position, for example, the position for the sample adding module 20 to suck the sample.

[0075] The sample adding module 20 includes a sample needle 21 and a moving device 22. The moving device 22 can drive the sample needle 21 to move to suck the sample and discharge it into the accommodating device 32 of the electrolyte detection module 30. In some embodiments, the number of sample needles 21 can be one or more. In some embodiments, when the sample needle 21 is multiple, the moving device 22 can drive these sample needles 21 to move independently. The moving device 22 can be a two-dimensional or three-dimensional driving mechanism, which can be designed according to specific needs.

[0076] Referring to Figure 2 , Figure 3The electrolyte detecting module 30 comprises a detecting electrode 31, a containing device 32, a first power device 33, a detecting device (not shown), a pressure adjusting device 34, a diluent container 35 and a second power device 36. The detecting electrode 31 is used for selectively responding to specific ions in the passing sample. The containing device 32 is used for buffering the sample and diluting the sample when the indirect method is used for detection. The first power device 33 and the second power device 36 can be selected as syringes for driving the liquid to flow in the pipeline. Of course, the first power device 33 and the second power device 36 can also use pumps or other components. The diluent container 35 is used for storing diluent. In the flowing direction of the liquid, the diluent container 35, the containing device 32 and the detecting electrode 31 are sequentially communicated with the main pipeline. The second power device 36 is connected to the main pipeline between the diluent container 35 and the containing device 32 through a control valve 37. The first power device 33 is connected to the main pipeline after the detecting electrode 31 through the control valve 37. In addition, the main pipeline between the containing device 32 and the diluent container 35 can also be connected with a degassing device 38, a thermal stabilizing device 39 and other components.

[0077] With reference to Figure 3 , Figure 4 , Figure 3 The detecting flow channel 3112 and the selective membrane 312 are hidden in the shell 311. The detecting electrode 31 comprises the shell 311, the selective membrane 312 and an electrode rod 313. The shell 311 has an electrode cavity 3111 and a detecting flow channel 3112. In the normal use state, the electrode cavity 3111 is isolated from the external environment, and the internal pressure is equal to the environmental pressure when the detecting electrode 31 is manufactured, which is usually 101 Kpa. The detecting flow channel 3112 is communicated with the external environment, and the electrode cavity 3111 contains an electrolyte solution. The selective membrane 312 is arranged between the electrode cavity 3111 and the detecting flow channel 3112. Specifically, an opening is arranged on the flow channel wall of the detecting flow channel 3112. The selective membrane 312 is installed at the opening and seals the opening, so that one side of the selective membrane 312 is in contact with the electrolyte solution in the electrode cavity 3111, and the other side is in contact with the sample in the detecting flow channel 3112. The electrolyte solution and the sample are isolated by the selective membrane 312. The electrode rod 313 is inserted into the electrode cavity 3111 and is in contact with the electrolyte solution in the electrode cavity 3111.

[0078] Currently, the detection methods of electrolyte content mainly include direct detection method and indirect detection method. The direct detection method refers to that the sample directly flows through the detection electrode 31 without dilution, and the indirect detection method refers to that the sample flows through the detection electrode 31 after dilution. The typical working process based on the direct detection method is as follows: the second power device 36 injects the diluent in the diluent container 35 into the containing device 32, and then the first power device 33 drives the diluent in the containing device 32 to flow through the detection electrode 31 and discharge, and the detection device detects the potential of the diluent. Then the moving device 22 drives the sample needle 21 to obtain the sample from the sample container 40, and then transfers the sample to the containing device 32, and the first power device 33 drives the sample in the containing device 32 to flow through the detection electrode 31 and discharge, and the detection device detects the potential of the sample. The content of the electrolyte can be judged by the potential difference between the diluent and the sample. In addition, in order to avoid pollution between samples, the pipeline and the container need to be flushed by the diluent before and / or after each detection.

[0079] The typical working process based on the indirect detection method is as follows: the second power device 36 injects the diluent in the diluent container 35 into the containing device 32, and then the first power device 33 drives the diluent in the containing device 32 to flow through the detection electrode 31 and discharge, and the detection device detects the potential of the diluent. Then the second power device 36 injects the diluent in the diluent container 35 into the containing device 32 again, the moving device 22 drives the sample needle 21 to obtain the sample from the sample container 40, and then transfers the sample to the containing device 32, and the sample and the diluent are uniformly mixed to form a mixed liquid by the stirring device. Finally, the first power device 33 drives the mixed liquid in the containing device 32 to flow through the detection electrode 31 and discharge, and the detection device detects the potential of the mixed liquid. The content of the electrolyte can be judged by the potential difference between the diluent and the mixed liquid. In addition, in order to avoid pollution between samples, the pipeline and the container need to be flushed by the diluent before and / or after each detection.

[0080] When the sample analyzer operates in a normal atmospheric pressure environment, the gas pressure in the electrode cavity 3111 can be balanced with the gas pressure in the detection flow channel 3112. However, when the sample analyzer operates in a low pressure environment (for example, operates in a plateau area), the gas pressure in the detection flow channel 3112 decreases (for example, below 70Kpa) with the decrease of the environmental gas pressure, while the gas pressure in the electrode cavity 3111 still maintains at 101Kpa, causing the selective membrane 312 to protrude to the detection flow channel 3112 due to the imbalance of the pressure on both sides (as shown in FIG. 13B). Figure 5As shown in FIG. 6, when the sample analysis instrument is operated in a low pressure environment, the pressure difference between the two sides of the selective membrane 312 will cause the deformation of the selective membrane 312, thereby causing the cross-sectional area of the detection flow channel 3112 to decrease, the flow resistance of the liquid to increase, and the discharge of the liquid (including but not limited to the sample liquid, the dilution liquid, and the mixture of the sample liquid and the dilution liquid) to be blocked. The discharge of the liquid being blocked will cause a series of problems, for example, when the direct detection method is used for detection, the discharge of the dilution liquid for washing will be blocked, which will affect the washing effect and cause the sample to be left (the sample without dilution has a high concentration, and if the washing is not complete, the sample will be left, which will pollute the subsequent sample). When the indirect detection method is used for detection, the discharge of the dilution liquid for detecting the electric potential will be blocked, which will cause the dilution liquid in the accommodation device 32 to not be completely discharged, and the residual dilution liquid in the accommodation device 32 will be mixed into the subsequent sample, which will cause the actual dilution multiple of the sample to increase, and the detection result to be lower than the actual concentration. In addition, when the indirect detection method is used for detection, the deformation of the selective membrane 312 will also cause the dilution liquid for washing to not be completely discharged, which will further increase the amount of residual dilution liquid, and the detection result will deviate from the actual concentration.

[0081] Based on the above, the electrolyte detection module 30 in the embodiments of the present application further includes a pressure adjusting device 34. When there is a pressure difference between the two sides of the selective membrane 312, the pressure adjusting device 34 can adjust the pressure value in the electrode cavity 3111, thereby balancing the pressure on the two sides of the selective membrane 312, reducing or eliminating the deformation of the selective membrane 312, and improving a series of problems caused by the discharge of the liquid being blocked.

[0082] As an embodiment of the pressure adjusting device 34, the pressure adjusting device 34 includes a volume adjusting assembly. The volume adjusting assembly adjusts the volume of the electrode cavity 3111 to adjust the pressure value in the electrode cavity 3111. Specifically, when the sample analysis instrument is operated in a low pressure environment, the volume adjusting assembly can increase the volume of the electrode cavity 3111, thereby reducing the pressure of the electrode cavity 3111, to maintain the pressure balance on the two sides of the selective membrane 312.

[0083] Referring to Figure 3 In some embodiments, the volume adjusting assembly includes an adjusting component 341 connected to the shell 311, at least partially inserted into the electrode cavity 3111, and capable of moving relative to the shell 311 to adjust the volume of the inserted part. Referring to Figure 6 When it is necessary to reduce the pressure of the electrode cavity 3111, reducing the volume of the adjusting component 341 inserted into the electrode cavity 3111 can increase the volume of the electrode cavity 3111.

[0084] In some embodiments, the adjusting component 341 is connected with the shell 311 through threads, and as the adjusting component 341 rotates, the adjusting component 341 can move axially relative to the shell 311, so as to adjust the volume of the electrode cavity 3111 into which the adjusting component 341 extends, and the adjustment is simple and can be completed by an operator with the aid of a simple tool or without the aid of a tool. Figure 3 As shown in the drawings, the electrode cavity 3111 extends through the shell 311, thereby forming a mounting hole, i.e., the mounting hole belongs to a part of the electrode cavity 3111. The inner wall of the mounting hole is provided with internal threads, and the outer wall of the adjusting component 341 is provided with external threads, and the adjusting component 341 is arranged in the mounting hole. When the adjusting component 341 moves from the state shown in the drawings to the state shown in the drawings, the volume of the electrode cavity 3111 increases, and the gas pressure decreases. Figure 3 As shown in the drawings, the electrode cavity 3111 extends through the shell 311, thereby forming a mounting hole, i.e., the mounting hole belongs to a part of the electrode cavity 3111. The inner wall of the mounting hole is provided with internal threads, and the outer wall of the adjusting component 341 is provided with external threads, and the adjusting component 341 is arranged in the mounting hole. When the adjusting component 341 moves from the state shown in the drawings to the state shown in the drawings, the volume of the electrode cavity 3111 increases, and the gas pressure decreases. Figure 6 As shown in the drawings, the electrode cavity 3111 extends through the shell 311, thereby forming a mounting hole, i.e., the mounting hole belongs to a part of the electrode cavity 3111. The inner wall of the mounting hole is provided with internal threads, and the outer wall of the adjusting component 341 is provided with external threads, and the adjusting component 341 is arranged in the mounting hole. When the adjusting component 341 moves from the state shown in the drawings to the state shown in the drawings, the volume of the electrode cavity 3111 increases, and the gas pressure decreases.

[0085] In order to realize the sealing of the electrode cavity 3111, the pressure adjusting device 34 further comprises a sealing ring 342, so as to Figure 3 As shown in the drawings, the hole wall of the mounting hole comprises a connecting section 3113 and a sealing section 3114 arranged axially, wherein the connecting section 3113 is located on the outer side, and the sealing section 3114 is located on the inner side, the connecting section 3113 is provided with internal threads, and the inner surface of the sealing section 3114 is smooth, and correspondingly, the adjusting component 341 comprises a connecting part 3411 and a sealing part 3412 arranged axially, the connecting part 3411 is provided with external threads, and the sealing part 3412 is provided with an annular groove, the sealing ring 342 is sleeved on the sealing part 3412 and located in the annular groove, and the outer side of the sealing ring 342 is in close abutment with the sealing section 3114, so that the sealing ring 342 can maintain sealed contact with the sealing section 3114 during the process of moving up and down with the adjusting component 341.

[0086] The sealing ring 342 can be provided as one or more, and when the sealing ring 342 is provided as multiple, the multiple sealing rings 342 are distributed along the axial direction of the adjusting component 341, so as to improve the sealing performance.

[0087] One end of the adjusting component 341 is located on the outer side of the shell 311 to form an operating part, so as to facilitate the operator to drive the adjusting component 341. When the electrolyte detection module 30 is installed into the shell of the sample analyzer, the operating part of the adjusting component 341 should be in a position convenient to contact, for example, an operating hole is arranged on the shell, the operating hole is sealed by a cover, and the operating part is arranged towards the operating hole, and when the gas pressure needs to be adjusted, the operator only needs to remove the cover to contact the adjusting component 341. Of course, the adjusting component 341 can also be driven mechanically, for example, the pressure adjusting device 34 further comprises a power device not shown, which can drive the adjusting component 341 to move for gas pressure adjustment, and the power device can be started based on user operation or automatically started based on the parameters detected by the detection sensor, thereby realizing automatic control.

[0088] It should be noted that, with reference to Figure 3 The shell 311 further comprises a first sleeve 3116, which defines the connecting section 3113. By providing the first sleeve 3116, the length of the thread on the connecting section 3113 can be extended, and the stability of the connection between the adjusting component 341 and the connecting section 3113 can be increased.

[0089] It should be noted that the shell 311 further comprises a second sleeve 3117, which defines the sealing section 3114. By providing the second sleeve 3117, the length of the sealing section 3114 can be increased, and the moving distance of the adjusting component 341 can be increased while ensuring sealing.

[0090] The first sleeve 3116 and the second sleeve 3117 can be independent parts or part of the shell 311.

[0091] In alternative embodiments, the connecting section 3113 is located on the inner side, and the sealing section 3114 is located on the outer side. In alternative embodiments, the sealing ring 342 can also be fixed on the sealing section 3114 and sleeved on the outer side of the sealing portion 3412. The adjusting component 341 can move relative to the sealing ring 342 and maintain sealing contact.

[0092] With reference to Figure 7 In some other embodiments of the volume adjusting assembly, the volume adjusting assembly comprises an elastic film 343 connected to the shell 311 for separating the electrode cavity 3111 from the external environment. Specifically, the shell 311 is provided with an opening, and the elastic film 343 is fixedly connected to the shell 311 by adhesion or the like and closes the opening. The elastic modulus of the elastic film 343 is smaller than the elastic modulus of the selective film 312. For example, the elastic film 343 can be made of PVC, silicone rubber or other materials that are elastic and non-polluting. When the sample analyzer operates in a low-pressure environment, the elastic film 343 is more likely to deform than the selective film 312. Therefore, the elastic film 343 will protrude outward before the selective film 312. With the protrusion of the elastic film 343, the volume of the electrode cavity 3111 increases, and the air pressure decreases. In this way, the deformation of the selective film 312 can be reduced or eliminated.

[0093] With reference to Figure 8In some other embodiments of the volume adjusting assembly, the pressure adjusting device 34 comprises a gas permeable membrane 344 connected to the housing 311 for separating the electrode cavity 3111 from the external environment. Specifically, an opening is provided on the housing 311, and the gas permeable membrane 344 is fixedly connected to the housing 311 by adhesion or the like and seals the opening. The gas permeable membrane 344 allows gas to flow from the high pressure side to the low pressure side and blocks liquid from passing through. For example, the gas permeable membrane 344 can be made of PET, PE, PES or other polymer materials. When the sample analyzer is operated in a low pressure environment, the gas pressure inside and outside the sample analyzer becomes inconsistent. In this case, the gas can spontaneously flow from the high pressure side to the low pressure side, i.e. from the electrode cavity 3111 to the detection flow channel 3112, under the action of the pressure difference, until the gas pressure on both sides of the gas permeable membrane 344 is balanced.

[0094] It should be noted that, Figure 7 With Figure 8 The elastic membrane 343 and the gas permeable membrane 344 in the embodiments shown in the drawings automatically balance the pressure without human intervention, which can simplify the operation.

[0095] In addition to adjusting the gas pressure by changing the volume, the present application also proposes other ways to adjust the gas pressure. Referring to Figure 9 、 Figure 10 As another embodiment of the pressure adjusting device 34, the housing 311 has a vent hole 3115, and the pressure adjusting device 34 comprises a plugging member 345 connected to the housing 311 and sealing the vent hole 3115. When the sample analyzer is operated in a low pressure environment, the plugging member 345 can move relative to the housing 311 to make the electrode cavity 3111 communicate with the external environment, so that the pressure on both sides of the selective membrane 312 is balanced. After the pressure is balanced, the plugging member 345 can seal the vent hole 3115 again.

[0096] The plugging member 345 can be a threaded plug as shown in the drawings. Correspondingly, a threaded hole is provided on the housing 311, the vent hole 3115 communicates with the threaded hole, and the plugging member 345 is threadedly connected to the housing 311 through the threaded hole. When the plugging member 345 is installed in place, the plugging member 345 will seal the vent hole 3115. When the plugging member 345 is screwed outwards, the vent hole 3115 communicates with the external environment. In order to enhance the sealing capacity, the plugging member 345 can seal the vent hole 3115 through a sealing gasket 346 when the plugging member 345 is installed in place.

[0097] In alternative embodiments, the plugging member 345 can be a rubber plug which is inserted into the vent hole 3115 to seal the vent hole 3115.

[0098] In alternative embodiments, referring to Figure 11The plugging component 345 can be a cured gel. In addition to being used for ventilation, the vent hole 3115 can also be used as a liquid injection hole. That is, during preparation, the detection electrode 31 is first injected with electrolyte through the vent hole 3115, and then the vent hole 3115 is sealed with the sealing gel. When it is necessary to balance the air pressure inside and outside the electrode cavity 3111, the plugging component 345 can be moved relative to the shell 311 by removing the gel, so that the vent hole 3115 is in an open state. The gel can be completely removed, or it can be partially removed, for example, by forming a puncture hole in the gel with a puncture needle. It should be noted that after the air pressure inside and outside the electrode cavity 3111 is balanced, the vent hole 3115 can be sealed again with the sealing gel.

[0099] The sample analyzer in the embodiment further includes a controller that is not shown. The controller can control the pressure adjusting device 34 to adjust the air pressure value in the electrode cavity 3111 when the liquid discharge of the containing device 32 is abnormal, so as to realize automatic adjustment of the air pressure. In an alternative embodiment, the controller can issue a prompt signal to remind the operator to adjust the air pressure when the liquid discharge of the containing device 32 is abnormal.

[0100] In a specific embodiment, the electrolyte detection module 30 detects relevant parameters to determine whether liquid discharge is abnormal. The electrolyte detection module 30 further includes a sensor assembly that is not shown. The sensor assembly can detect the liquid discharge pressure of the containing device 32. In this case, the sensor assembly includes a pressure sensor connected to the pipeline downstream of the containing device 32. When the pressure sensor detects that the liquid discharge pressure is greater than or equal to a preset threshold value, it means that the liquid flow is blocked, and there is a problem of abnormal liquid discharge. The sensor assembly can also detect the liquid level of the containing device 32. In this case, the sensor assembly includes a liquid level sensor connected to the containing device 32. When the liquid discharge of the containing device 32 is completed, if the liquid level in the containing device 32 is greater than or equal to a preset threshold value, it means that there is residual liquid in the containing device 32, and there is a problem of abnormal liquid discharge.

[0101] In addition, the sample analyzer further includes an air pressure detection device. When the air pressure detection device detects that the ambient air pressure is less than a preset threshold value, the controller controls the pressure adjusting device 34 to adjust the air pressure value in the electrode cavity 3111. In an alternative embodiment, the controller can issue a prompt signal to remind the operator to adjust the air pressure when the air pressure detection device detects that the ambient air pressure is less than a preset threshold value.

[0102] It should be noted that a single parameter anomaly has the possibility of false positives, for example, when the pressure sensor detects the liquid discharge pressure greater than or equal to the preset threshold value, and the liquid level is normal, it may also be that the pressure sensor itself fails; when the liquid level sensor detects the liquid level height greater than or equal to the preset threshold value, and the pressure is normal, it may also be that the pipeline joint has a gas leak. Therefore, the combination of multiple parameters can be used for judgment, for example, when the pressure sensor detects the liquid discharge pressure greater than or equal to the preset threshold value, and the liquid level sensor detects the liquid level height greater than or equal to the preset threshold value, the controller controls the pressure adjusting device 34 to adjust the gas pressure value in the electrode cavity 3111, or sends a prompt signal. For example, when the pressure sensor detects the liquid discharge pressure greater than or equal to the preset threshold value, the liquid level sensor detects the liquid level height greater than or equal to the preset threshold value, and the gas pressure detection device detects the ambient gas pressure less than the preset threshold value, the controller controls the pressure adjusting device 34 to adjust the gas pressure value in the electrode cavity 3111, or sends a prompt signal, which can exclude the situation that the liquid level and the liquid discharge pressure are both abnormal due to the accumulation of pollutants in the pipeline.

[0103] The second embodiment of the present application also provides a sample analyzer, which comprises a sample module 10, a sample adding module 20 and an electrolyte detection module 30. The sample module 10 and the sample adding module 20 can adopt the corresponding modules in the first embodiment. The detection electrode 31, the accommodating device 32, the first power device 33, the detection device (not shown), the diluent container 35 and the second power device 36 in the electrolyte detection module 30 can adopt the corresponding devices in the first embodiment. The difference between the second embodiment and the first embodiment is that the second embodiment does not provide the pressure adjusting device 34, but improves the problem of liquid flow obstruction by increasing the detection flow channel 3112 local area cross-sectional area.

[0104] Referring to Figure 12 , Figure 13 , the detection flow channel 3112 comprises a first flow channel segment 3118 and a second flow channel segment 3119. The selective membrane 312 is connected to the shell 311 and is arranged between the electrode cavity 3111 and the first flow channel segment 3118. The initial cross-sectional area of the first flow channel segment 3118 is greater than that of the second flow channel segment 3119. The selective membrane 312 is an elastic membrane 343. When the sample analyzer operates in a low-pressure environment, even if the selective membrane 312 deforms into the detection flow channel 3112, the first flow channel segment 3118 can still maintain a certain cross-sectional area to ensure that the liquid can flow smoothly.

[0105] In some embodiments, referring to Figure 12 , the pipe wall of the first flow channel segment 3118 is provided with a recess, and the recess is arranged on the opposite side of the selective membrane 312, and Figure 13In comparison, the selective membrane 312 does not need to be concave, which facilitates the selective membrane 312 to contact the sample and reduces the use amount of the sample.

[0106] In addition, in order to avoid the cross-sectional area difference of the first flow channel section 3118 at different positions being too large after the deformation of the selective membrane 312, and reduce the flow resistance, the two sides of the concave part are further provided with flow guide surfaces.

[0107] The third embodiment of the present application further provides a sample analyzer, which comprises a sample module 10, a sample adding module 20 and an electrolyte detection module 30. The sample module 10 and the sample adding module 20 can adopt the corresponding modules in the first embodiment. The detection electrode 31, the accommodating device 32, the first power device 33, the detection device (not shown), the diluent container 35 and the second power device 36 in the electrolyte detection module 30 can adopt the corresponding devices in the first embodiment. The difference between the third embodiment and the first embodiment is that the third embodiment does not provide the pressure adjusting device 34, but improves the problem of liquid flow obstruction by increasing the overall cross-sectional area of the detection flow channel 3112.

[0108] In the third embodiment, the diameter of the detection flow channel 3112 is 1.5 mm to 2 mm, and the protrusion height of the deformed selective membrane 312 is usually not more than 0.8 mm. Therefore, by increasing the diameter of the detection flow channel 3112 to the above range, the problem of liquid flow obstruction can be improved. It should be noted that increasing the diameter of the detection flow channel 3112 will increase the surface area of the selective membrane 312, thereby increasing the cleaning difficulty and the use amount of the sample. Therefore, the skilled in the art usually does not expand the diameter of the detection flow channel 3112. In the third embodiment, the diameter of the detection flow channel 3112 is set to the above range, which can improve the problem of liquid flow obstruction, and also does not excessively increase the cleaning difficulty and the use amount of the sample.

[0109] The fourth embodiment of the present application further provides a sample analyzer, which comprises a sample module 10, a sample adding module 20 and an electrolyte detection module 30. The sample module 10 and the sample adding module 20 can adopt the corresponding modules in the first embodiment. The detection electrode 31, the accommodating device 32, the first power device 33, the detection device (not shown), the diluent container 35 and the second power device 36 in the electrolyte detection module 30 can adopt the corresponding devices in the first embodiment. The difference between the fourth embodiment and the first embodiment is that the fourth embodiment does not provide the pressure adjusting device 34, but improves the problem of liquid flow obstruction by limiting the deformation of the selective membrane 312.

[0110] Reference Figure 14The limiting device 310 covers one side of the selective membrane 312 facing the detection flow channel 3112, and can resist the selective membrane 312 to limit the deformation of the selective membrane 312 towards the detection flow channel 3112 when there is a pressure difference between the two sides of the selective membrane 312. It should be noted that the limiting device 310 can be attached to the selective membrane 312 so that the selective membrane 312 cannot be deformed substantially, or the limiting device 310 can be spaced apart from the selective membrane 312 by a small distance to constrain the deformation of the selective membrane 312 within a small range.

[0111] The limiting device 310 can be a hard filter screen provided with liquid passing holes, and the to-be-measured liquid can pass in and out of the limiting device 310 through the liquid passing holes, so as to ensure that the selective membrane 312 can be in contact with the to-be-measured liquid.

[0112] The fifth embodiment of the present application also proposes an electrolyte detection module 30, which comprises a detection electrode 31, a containing device 32, a first power device 33, a detection device (not shown), a pressure adjusting device 34, a diluent container 35 and a second power device 36, and all the above-mentioned devices can adopt the corresponding devices in the first embodiment, so as to also improve the problem of liquid flow obstruction.

[0113] The embodiments of the present application are described in detail above in combination with the drawings, but the present application is not limited to the above-mentioned embodiments, and various changes can be made within the knowledge range possessed by those skilled in the art without departing from the purpose of the present application. In addition, the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

Claims

1. A sample analyzer characterized by, The electrolyte detection module comprises a detection electrode, a containing device, a power device, a detection device and a pressure adjusting device, the detection electrode comprises a shell and a selective membrane, the shell has an electrode cavity and a detection flow channel, the electrode cavity contains an electrolyte solution, the selective membrane is connected to the shell and is arranged between the electrode cavity and the detection flow channel, the containing device is used for containing a to-be-tested liquid, the power device is used for providing a driving force for the to-be-tested liquid in the containing device to flow through the detection flow channel, the detection device is used for acquiring an electric potential when the liquid flowing through the detection flow channel, and the pressure adjusting device is used for adjusting the air pressure value in the electrode cavity. The sample module is provided with at least one sample site for placing a sample container for containing a to-be-tested liquid. The sample adding module comprises a moving device and a sample needle arranged on the moving device, the moving device is used for driving the sample needle to move between the sample site and the containing device, so as to suck the to-be-tested liquid at the sample site and discharge the to-be-tested liquid to the containing device. The pressure adjusting device comprises a volume adjusting assembly, and the volume adjusting assembly adjusts the air pressure value in the electrode cavity by adjusting the volume of the electrode cavity.

2. The sample analyzer of claim 1, wherein, The volume adjusting assembly comprises an adjusting component connected to the shell, at least partially inserted into the electrode cavity and capable of moving relative to the shell to adjust the volume of the inserted part.

3. The sample analyzer of claim 2, wherein, The volume adjusting assembly further comprises a sealing ring, the electrode cavity comprises a mounting hole arranged through the shell, the hole wall of the mounting hole comprises an axial connecting section and a sealing section, the adjusting component comprises an axial connecting part and a sealing part, the connecting part is threadedly connected with the connecting section, and the sealing ring is located between the sealing part and the sealing section.

4. The sample analyzer of claim 3, wherein, The volume adjusting assembly comprises an elastic membrane connected to the shell and used for separating the electrode cavity from the external environment, and the elastic modulus of the elastic membrane is smaller than the elastic modulus of the selective membrane.

5. The sample analyzer of claim 2, wherein, The pressure adjusting device comprises a gas-permeable membrane connected to the shell and used for separating the electrode cavity from the external environment, and the gas-permeable membrane can make gas flow from a high-pressure side to a low-pressure side.

6. The sample analyzer of claim 1, wherein, The shell has a vent hole, the pressure adjusting device comprises a plugging component connected to the shell and closing the vent hole, and the plugging component can move relative to the shell to make the electrode cavity and the external environment communicate through the vent hole.

7. The sample analyzer of claim 1, wherein, The sample analyzer further comprises a controller, and the controller is used for controlling the pressure adjusting device to adjust the air pressure value in the electrode cavity when the containing device abnormally discharges liquid.

8. The sample analyzer of claim 1, wherein, The electrolyte detection module further comprises a sensor assembly for detecting the liquid level and / or the discharge pressure in the containing device; and the abnormal discharge of the containing device comprises at least one of the following:

9. The sample analyzer of claim 8, wherein, After the containing device completes the liquid discharge, the liquid level in the containing device is greater than or equal to a preset threshold value; During the liquid discharge of the containing device, the discharge pressure is greater than or equal to a preset threshold value. ​ 10. The sample analyzer of claim 9, wherein, The sample analyzer further comprises an air pressure detection device, and the controller is further configured to control the pressure adjusting device to adjust the air pressure value in the electrode cavity when the ambient air pressure detected by the air pressure detection device is less than a preset threshold.

11. A sample analyzer characterized by, The sample analyzer comprises: The electrolyte detection module comprises a detection electrode, a containing device, a power device, and a detection device. The detection electrode comprises a shell and a selective membrane. The shell has an electrode cavity and a detection flow channel. The electrode cavity contains an electrolyte solution. The detection flow channel comprises a first flow channel section and a second flow channel section. The selective membrane is connected to the shell and is arranged between the electrode cavity and the first flow channel section. The selective membrane is an elastic membrane. The initial cross-sectional area of the first flow channel section is greater than that of the second flow channel section. The containing device is used to contain a liquid to be tested. The power device is used to provide a driving force for the liquid to be tested in the containing device to flow through the detection flow channel. The detection device is used to obtain the electric potential when the liquid flows through the detection flow channel. The sample module is provided with at least one sample site for placing a sample container containing a liquid to be tested. The sample module is provided with at least one sample site for placing a sample container containing a liquid to be tested.

12. The sample analyzer of claim 11, wherein, The sample module is provided with at least one sample site for placing a sample container containing a liquid to be tested.

13. A sample analyzer characterized by, The tube wall of the first flow channel section is provided with a recess, which is arranged on the opposite side of the selective membrane. The sample analyzer comprises: The electrolyte detection module comprises a detection electrode, a containing device, a power device, and a detection device. The detection electrode comprises a shell and a selective membrane. The shell has an electrode cavity and a detection flow channel. The electrode cavity contains an electrolyte solution. The selective membrane is connected to the shell and is arranged between the electrode cavity and the detection flow channel. The containing device is used to contain a liquid to be tested. The power device is used to provide a driving force for the liquid to be tested in the containing device to flow through the detection flow channel. The detection device is used to obtain the electric potential when the liquid flows through the detection flow channel. The limiting device can resist the selective membrane to limit the deformation of the selective membrane towards the detection flow channel. The limiting device has a liquid passing hole for the liquid to be tested to pass through. The sample module is provided with at least one sample site for placing a sample container containing a liquid to be tested.

14. A sample analyzer characterized by, The sample module is provided with at least one sample site for placing a sample container containing a liquid to be tested. The sample module is provided with at least one sample site for placing a sample container containing a liquid to be tested. The sample module is provided with at least one sample site for placing a sample container containing a liquid to be tested. An electrolyte detection module comprises a detection electrode, a containing device, a power device and a detection device. The detection electrode comprises a shell and a selective membrane. The shell has an electrode cavity and a detection flow channel. The electrode cavity contains an electrolyte solution. The selective membrane is connected to the shell and is arranged between the electrode cavity and the detection flow channel. The diameter of the detection flow channel is 1.5-2 mm. The containing device is used for containing a liquid to be detected. The power device is used for providing a driving force for the liquid to be detected in the containing device to flow through the detection flow channel. The detection device is used for acquiring an electric potential when the liquid flows through the detection flow channel. A sample module is provided with at least one sample site for placing a sample container containing a liquid to be detected. A sample adding module comprises a moving device and a sample needle arranged on the moving device. The moving device is used for driving the sample needle to move between the sample site and the containing device, so as to draw the liquid to be detected by the sample needle at the sample site and discharge the liquid to be detected to the containing device.

15. An electrolyte detection module characterized by, The detection electrode comprises a shell and a selective membrane. The shell has an electrode cavity and a detection flow channel. The electrode cavity contains an electrolyte solution. The selective membrane is connected to the shell and is arranged between the electrode cavity and the detection flow channel. The containing device is used for containing a liquid to be detected. The power device is used for providing a driving force for the liquid to be detected in the containing device to flow through the detection flow channel. The detection device is used for acquiring an electric potential when the liquid to be detected flows through the detection flow channel. The pressure adjusting device is used for adjusting the air pressure value in the electrode cavity. ​

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