Liquid crystal cream with high penetration ability, preparation method and application

Abstract

This invention discloses a liquid crystal cream with high penetration capability, its preparation method, and its application. The liquid crystal cream comprises: an oleophilic emulsifier, a hydrophilic emulsifier, long-chain fatty alcohols and esters, and the remainder being humectants, thickeners, chelating agents, emollients, preservatives, active ingredients, and deionized water. This invention's small liquid crystal moisturizing cream has an excellent skin feel, good absorption, is breathable and non-comedogenic, and can form a biomimetic moisturizing film with good skin affinity on the skin, enhancing skin hydration and moisturizing ability, effectively improving skin condition, and achieving the effect of protecting and repairing the skin barrier. The system exhibits good long-term stability and a complete liquid crystal structure. Furthermore, tests show that this small liquid crystal cream has a significant penetration effect on both oil-soluble and water-soluble active ingredients. It is expected to achieve better skincare effects by incorporating different active ingredients in the field of functional skincare cosmetics.

Description

Technical Field

[0001] This invention relates to the field of creams, and in particular to a liquid crystal cream with highly efficient penetration, its preparation method, and its application. Background Technology

[0002] Because liquid crystal structures are similar to the internal structure of human skin, they possess excellent moisturizing and water-locking functions. Therefore, liquid crystal creams can provide superior moisturizing and skincare effects. However, existing technologies for preparing liquid crystal creams, such as patent application number 202310718591.5 entitled "A Liquid Crystal Cream and Its Preparation Method and Application," disclose that "by mass percentage, the liquid crystal cream comprises 5%–20% D phase, 5%–40% oil phase, and 40%–90% water phase; the D phase comprises emulsifier, co-emulsifier, polyol, and deionized water, and the mass ratio of the emulsifier, co-emulsifier, polyol, and deionized water is (3–5):(3–8):(2–6):(1–3). In this invention, using D…" The method for preparing liquid crystal creams using phase emulsification can effectively improve the utilization rate of emulsifiers, making the liquid crystal structure of the resulting product more stable and providing better moisturizing effects. It also provides a wider selection of raw materials. Furthermore, the cream prepared using this method has uniform particle size and good stability, exhibiting excellent moisturizing effects when applied to cosmetics and possessing broad market prospects. While the existing technology can produce creams with uniform particle size, the resulting liquid crystal particles are relatively large, exhibiting poor long-term stability, unpleasant skin feel, and poor actual penetration of water-soluble and oil-soluble active ingredients. Summary of the Invention

[0003] The purpose of this invention is to provide a liquid crystal cream with highly efficient penetration, its preparation method, and its application. This invention can obtain stable small-particle-size liquid crystals (below 5 μm). When used in cosmetics, these crystals not only possess an excellent biomimetic sebum-like liquid crystal structure but also have a light, non-sticky feel, rapid absorption, and, in particular, significantly improve the transdermal absorption of both water-soluble and oil-soluble active ingredients.

[0004] The technical solution of the present invention: a liquid crystal cream with high penetration ability, comprising the following components: lipophilic emulsifier, hydrophilic emulsifier, and long-chain fatty alcohols and esters; further comprising one or more of moisturizers, thickeners, emollients, preservatives, active ingredients, oils, chelating agents, and deionized water;

[0005] The hydrophilic emulsifier is composed of lecithin emulsifier, anionic emulsifier and polyglycerol emulsifier in a mass ratio of 1-20:8-40:2-60;

[0006] The lipophilic emulsifier includes one of the following: SPAN-type emulsifiers, polyether emulsifiers, or glyceryl ester emulsifiers.

[0007] In the aforementioned liquid crystal cream with high penetration ability, the mass fraction of the lecithin emulsifier is 0.05%-1%.

[0008] In the aforementioned liquid crystal cream with high penetration capability, the mass fraction of the anionic emulsifier is 0.4%-2%.

[0009] In the aforementioned liquid crystal cream with high penetration ability, the mass fraction of the polyglycerol emulsifier is 0.1%-3%.

[0010] In the aforementioned liquid crystal cream with high penetration ability, the mass fraction of the long-chain fatty alcohol and its ester is 1%-6%.

[0011] In the aforementioned liquid crystal cream with high penetration ability, the long carbon chain fatty alcohol and ester are fatty alcohols and esters with C16 or higher.

[0012] The long-chain fatty alcohols and esters include one or more of cetyl alcohol, stearyl alcohol, arachidyl alcohol, behenyl alcohol, squalene, cetearyl alcohol, myristyl myristate and / or pentaerythritol distearate.

[0013] In the aforementioned liquid crystal cream with high penetration ability, the lecithin emulsifiers include hydrogenated lecithin and / or lysophosphatidylcholine.

[0014] In the aforementioned liquid crystal cream with high penetration ability, the anionic emulsifier includes one or more of the following: glyceryl stearate citrate, potassium cetyl phosphate, sodium stearoyl glutamate, sodium methylstearoyl taurate, sodium di(lauramide glutamine) lysine and / or C20-22 alcohol phosphate.

[0015] In the aforementioned liquid crystal cream with high penetration ability, the polyglycerol emulsifiers include one or more of the following: polyglycerol-2 stearate, polyglycerol-10 stearate, polyglycerol-10 myristate, polyglycerol-3 methyl glucoside distearate, polyglycerol-4 laurate, polyglycerol-6 distearate, polyglycerol-6 octastearate, and / or polyglycerol-10 dioleate.

[0016] In the aforementioned liquid crystal cream with high penetration capability, the lipophilic emulsifier includes one or more of the following: sorbitan sesquioleate, sorbitan stearate, sorbitan sesquistearate, sorbitan olive oil ester, glyceryl stearate, or stearyl alcohol polyether-2.

[0017] A method for preparing a liquid crystal cream with high penetration ability includes the following steps:

[0018] 1) Stir and disperse deionized water, thickener, chelating agent, humectant, lecithin emulsifier, and preservative evenly, and heat to 75℃-85℃ to obtain the aqueous phase;

[0019] 2) Heat and stir anionic emulsifiers, polyglycerol emulsifiers, lipophilic emulsifiers, long-chain fatty alcohols and esters, and oils until completely dissolved, and heat to 75℃-85℃ to obtain the oil phase;

[0020] 3) Add the oil phase to the aqueous phase and homogenize it for 3-8 minutes at 4000rpm-8000rpm using a homogenizer, then slowly stir and cool it in a water bath.

[0021] 4) Cool down to below 50℃, add the active ingredient, and stir to disperse evenly;

[0022] 5) Continue stirring in the water bath and slowly cool down to below 32°C to obtain liquid crystal cream.

[0023] Application of liquid crystal creams with high penetration ability in cosmetics.

[0024] Compared with existing technologies, this invention uses a combination of four specific emulsifiers (lecithin emulsifiers, anionic emulsifiers, polyglycerol emulsifiers, one of SPAN emulsifiers, polyether emulsifiers, or glyceryl ester emulsifiers) and long-chain fatty alcohols and their esters to obtain stable small-particle-size liquid crystals below 5 μm. When used in cosmetics, it not only has an excellent biomimetic sebum liquid crystal structure, but also has a light and non-sticky feel, is quickly absorbed, and can significantly improve the transdermal absorption of water-soluble and oil-soluble active ingredients.

[0025] The micro-liquid crystal moisturizing cream of this invention has an excellent skin feel, good absorption, is breathable and non-comedogenic. It forms a biomimetic moisturizing film with good skin affinity on the skin, enhancing skin hydration and moisturizing ability, effectively improving skin condition, and achieving the effect of protecting and repairing the skin barrier. The system exhibits good long-term stability and a complete liquid crystal structure. Furthermore, tests show that this micro-liquid crystal cream has a significant penetration effect on both oil-soluble and water-soluble active ingredients, and holds promise for achieving better skincare effects by incorporating different active ingredients in the field of functional skincare cosmetics. Attached Figure Description

[0026] Figure 1 This is a polarized photograph of Embodiment 1 of the present invention;

[0027] Figure 2 This is a polarized photograph of Embodiment 2 of the present invention;

[0028] Figure 3 This is a polarized photograph of Embodiment 3 of the present invention;

[0029] Figure 4 This is a polarized photograph of Embodiment 4 of the present invention;

[0030] Figure 5 This is a polarized photograph of Embodiment 5 of the present invention;

[0031] Figure 6 This is a polarized photograph of Embodiment 6 of the present invention;

[0032] Figure 7 This is a polarized photograph of Embodiment 7 of the present invention;

[0033] Figure 8 This is a polarized photograph of Embodiment 8 of the present invention;

[0034] Figure 9 This is a polarized photograph of Embodiment 9 of the present invention;

[0035] Figure 10 This is a polarized photograph of Embodiment 10 of the present invention;

[0036] Figure 11 This is a polarized photograph of Embodiment 11 of the present invention;

[0037] Figure 12 This is a polarized photograph of Embodiment 12 of the present invention;

[0038] Figure 13 This is a polarized photograph of Comparative Example 13 of the present invention;

[0039] Figure 14 This is a polarized photograph of Comparative Example 14 of the present invention;

[0040] Figure 15 This is a polarized photograph of Comparative Example 15 of the present invention;

[0041] Figure 16 This is a polarized photograph of Comparative Example 16 of the present invention;

[0042] Figure 17 This is a polarized photograph of Comparative Example 17 of the present invention;

[0043] Figure 18 This is a polarized photograph of Comparative Example 18 of the present invention;

[0044] Figure 19 This is a distribution diagram of tocopherol acetate content at different depths in the skin over time, as shown in Example 1.

[0045] Figure 20 This is a distribution diagram of niacinamide content at different depths of the skin over time, as shown in Example 12.

[0046] Note: The bottom right corner of the attached image shows a 10µm scale. Detailed Implementation

[0047] The present invention will be further described below with reference to the accompanying drawings and embodiments, but this should not be construed as limiting the present invention.

[0048] Example. A liquid crystal cream with high penetration ability comprises the following components: lipophilic emulsifier, hydrophilic emulsifier, and long-chain fatty alcohols and esters; it also includes one or more of moisturizers, thickeners, emollients, preservatives, active ingredients, oils, chelating agents, and deionized water;

[0049] The hydrophilic emulsifiers include lecithin emulsifiers, anionic emulsifiers, and polyglycerol emulsifiers;

[0050] The lipophilic emulsifier includes one of the following: SPAN-type emulsifiers, polyether emulsifiers, or glyceryl ester emulsifiers.

[0051] The mass fraction of the lecithin emulsifier is 0.05%-1%.

[0052] The mass fraction of the anionic emulsifier is 0.4%-2%.

[0053] The mass fraction of the polyglycerol emulsifier is 0.1%-3%.

[0054] The mass fraction of the long-chain fatty alcohols and their esters is 1%-6%.

[0055] The specific components are shown in Table 1.

[0056] Table 1: Liquid Crystal Cream Formulation

[0057]

[0058]

[0059] The long-chain fatty alcohols and esters are fatty alcohols and esters with C16 or more;

[0060] The long-chain fatty alcohols and esters include one or more of cetyl alcohol, stearyl alcohol, arachidyl alcohol, behenyl alcohol, squalene, cetearyl alcohol, myristyl myristate and / or pentaerythritol distearate.

[0061] Lecithin emulsifiers include hydrogenated lecithin and / or lysophosphatidylcholine.

[0062] The anionic emulsifiers include one or more of the following: glyceryl stearate citrate, potassium cetyl phosphate, sodium stearoyl glutamate, sodium methylstearoyl taurate, sodium di(lauramide glutamine) lysine, and / or C20-22 alcohol phosphate.

[0063] Polyglycerol emulsifiers include one or more of the following: polyglycerol-2 stearate, polyglycerol-10 stearate, polyglycerol-10 myristate, polyglycerol-3 methyl glucoside distearate, polyglycerol-4 laurate, polyglycerol-6 distearate, polyglycerol-6 octastearate, and / or polyglycerol-10 dioleate.

[0064] The lipophilic emulsifier includes one or more of the following: sorbitan sesquioleate, sorbitan stearate, sorbitan sesquistearate, sorbitan olive oil ester, glyceryl stearate, or stearyl alcohol polyether-2.

[0065] Examples of thickeners include, but are not limited to, hydroxypropyl methylcellulose, sodium polyacrylate grafted starch, acrylate copolymers, ammonium acryloyldimethyl taurate / VP copolymers, polyacrylate crosspolymer-6, acrylate / C10-30 alkanol acrylate crosspolymers, polyacryloyldimethyl taurate, sodium polyacrylate, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymers, xanthan gum, dehydroxanthan gum, and carbomers.

[0066] Examples of moisturizers include, but are not limited to, glycerin, dipropylene glycol, diglycerin, 1,3-butanediol, 1,3-propanediol, pentanediol, isopentanediol, hexanediol, erythritol, xylitol, sorbitol, mannitol, caprylyl glycol, ethylhexylglycerin, polyethylene glycol, polybutylene glycol, sodium polyglutamate, betaine, allantoin, trehalose, sodium hyaluronate, sodium pyrrolidone hydroxy acid, lactate, glyceryl polyethers, and polysaccharides.

[0067] Examples of chelating agents include, but are not limited to, EDTA-2Na and sodium phytate.

[0068] Examples of preservatives include, but are not limited to, sodium benzoate, phenoxyethanol, methylparaben, propylparaben, chlorphenesin, potassium sorbate, dehydroacetic acid, and capryloyl hydroxamic acid.

[0069] Examples of oils include, but are not limited to, caprylic / capric triglyceride, isononyl isononanoate, pentaerythritol tetra(ethylhexanoate), phytosterol isostearyl dioleate, squalane, polydimethylsiloxane, cetyl ethylhexanoate, hexyldecyl alcohol, propylene glycol didecyl ester, and hydrogenated polydecene.

[0070] Active ingredients include water-soluble active ingredients and oil-soluble active ingredients.

[0071] As water-soluble active ingredients, including but not limited to nicotinamide, D-panthenol, 3-o-ethyl ascorbic acid, ergothioneine, ascorbic acid, sodium ascorbate phosphate, and ascorbate glucoside.

[0072] As oil-soluble active ingredients, they include, but are not limited to, tocopheryl acetate, bisabolol, and ascorbate tetraisopalmitate.

[0073] A method for preparing a liquid crystal cream with high penetration ability includes the following steps:

[0074] 1) Stir and disperse deionized water, thickener, chelating agent, humectant, lecithin emulsifier, and preservative evenly, and heat to 75-85℃ (preferably 78℃) to obtain an aqueous phase;

[0075] 2) Anionic emulsifiers, polyglycerol emulsifiers, lipophilic emulsifiers, long-chain fatty alcohols and esters, and oils are heated and stirred until completely dissolved, and then heated to 75-85℃ (preferably 78℃) to obtain the oil phase;

[0076] 3) Add the oil phase to the aqueous phase and homogenize it at 4000rpm-8000rpm for 3-8 minutes (preferably 3 minutes) using a homogenizer, then slowly stir and cool it in a water bath.

[0077] 4) Cool down to below 50℃, add the active ingredient, and stir to disperse evenly;

[0078] 5) Continue stirring in the water bath and slowly cool down to below 32°C to obtain liquid crystal cream.

[0079] Application of liquid crystal creams with high penetration ability in cosmetics.

[0080] To fully understand the content of this invention, the technical solution of this invention will be further described and explained below with reference to specific embodiments. Without departing from the principle of this invention, several modifications and improvements can be made to the preparation method, and these should also be considered to fall within the protection scope of this invention.

[0081] Examples 1-12 describe the specific components of skincare products containing liquid crystal creams. Skincare products containing liquid crystal creams were prepared according to the formulations shown in Table 2. The emulsion particles, number of liquid crystals, and morphology were observed under an RH 2000 microscope. The average emulsion particle size was automatically counted using microscope software. The relative permeability of the active ingredients at different time points was measured using Raman spectroscopy. The relative permeability of human skin at 8 hours and the maximum penetration depth at 8 hours are shown in Table 2. Polarized light images are attached. Figure 1-12 .

[0082] The specific principle of Raman testing is as follows: Raman spectral imaging data processing includes spectral preprocessing and data analysis. Spectral preprocessing includes several steps such as cosmic ray removal, spectral smoothing, background noise removal, baseline calibration, and spectral normalization. Univariate data analysis primarily focuses on Raman spectral data analysis of biochemical substances corresponding to a specific peak position, revealing the distribution of that substance within human skin. Data analysis uses Labspec5 software to perform baseline calibration and confirm characteristic peak positions in the Raman spectrum, calculating peak intensity, peak shift, peak area, and full width at half maximum (FWHM). Simultaneously, Labspec6 software is used to perform numerical analysis of peak intensities at different depths and to plot their spatial distribution.

[0083] The product's penetration behavior was determined by using Raman signals, which distinguish the product from the intrinsic signals of the skin, to confirm its distribution at different skin depths.

[0084] Use Excel software to perform descriptive statistics on each measured value, including quantity, mean, standard deviation, minimum value, maximum value, etc.

[0085] Relative penetration rate % = Normalized (change in Raman characteristic peaks caused by product use) * 100%

[0086] Table 2: Formulations and Results of Examples 1-12

[0087]

[0088]

[0089] In Examples 1-12, the following thickeners were selected: ammonium acryloyl dimethyl taurate / VP copolymer; chelating agent: EDTA-2NA; humectants: glycerin, 1,2-hexanediol, 1,2-pentanediol; lecithin emulsifier: hydrogenated lecithin; anionic emulsifiers: glyceryl stearate citrate, sodium methylstearoyl taurate, C20-22 hydroxyphosphate; polyglycerol emulsifiers: polyglycerol-3-methylglucose distearate, polyglycerol-10 stearate; lipophilic emulsifiers: sorbitan stearate, glyceryl stearate; long-chain fatty alcohols and esters: cetearyl alcohol, behenyl alcohol, myristyl myristate; oils: caprylic / capric triglyceride; water-soluble active ingredient: nicotinamide; and oil-soluble active ingredient: tocopheryl acetate.

[0090] Phase A raw materials are one or more of the following: deionized water, ammonium acryloyldimethyl taurate / VP copolymer, EDTA-2NA, glycerol, 1,2-hexanediol, 1,2-pentanediol, p-hydroxyacetophenone, hydrogenated lecithin, and nicotinamide; the appropriate Phase A raw materials can be selected according to the specific embodiments.

[0091] Phase B raw materials are one or more of the following: glyceryl stearate citrate (or sodium methylstearoyl taurate or C20-22 hydroxyphosphate), polyglycerol-3-methylglucose distearate (or polyglycerol-10 stearate), sorbitan stearate (or glyceryl stearate), cetearyl alcohol (or behenyl alcohol or myristyl myristate), caprylic / capric triglyceride, and tocopheryl acetate; the appropriate Phase B raw materials can be selected according to the specific embodiments.

[0092] Preparation method: According to the components of each embodiment, the corresponding A phase raw materials are added to beakers in sequence, stirred and dispersed evenly, and heated to 78°C to obtain an aqueous phase; the corresponding B phase raw materials are added to another beaker in sequence, heated and stirred until completely dissolved, and heated to 78°C to obtain an oil phase; the oil phase is poured into the aqueous phase and homogenized for 3 minutes using an IKA device at 4000rpm-8000rpm; then the mixture is slowly stirred and cooled in a water bath; the temperature is lowered to below 32°C to obtain a liquid crystal cream.

[0093] The results of Examples 1-12 show that the average particle size of the prepared microcrystalline liquid crystal cream is below 5 μm, and it has a good penetration-enhancing effect on niacinamide and tocopheryl acetate. The relative penetration rate can reach more than 16% after 8 hours. The maximum skin penetration depth of the oil-soluble active ingredient tocopheryl acetate reaches 120 μm after 8 hours, and the maximum skin penetration depth of the water-soluble active ingredient niacinamide reaches 110 μm after 8 hours.

[0094] Stability results show that Examples 1-12 maintained a good liquid crystal structure after one month at 50℃, -10℃, and under light exposure, and after three months at 25℃, 45℃, and 5℃. This demonstrates excellent stability.

[0095] Comparative Example

[0096] Table 3: Formulations and Results of Comparative Examples 13-18

[0097]

[0098] In Comparative Examples 13-18, Comparative Examples 13-15 were combinations of emulsifier hydrogenated lecithin, glyceryl stearate citrate, and polyglycerol-3-methylglucose distearate with sorbitan stearate, respectively.

[0099] Comparative Example 16 was a combination of three emulsifiers: hydrogenated lecithin, polyglycerol-3-methylglucose distearate, and sorbitan stearate.

[0100] Comparative Example 17 was a combination of three emulsifiers: hydrogenated lecithin, glyceryl stearate citrate, and sorbitan stearate.

[0101] Comparative Example 18 was a combination of three emulsifiers: glyceryl stearate citrate, polyglycerol-3-methyl glucoside distearate, and sorbitan stearate.

[0102] Phase A raw materials include one or more of the following: deionized water, ammonium acryloyl dimethyl taurate / VP copolymer, EDTA-2NA, glycerol, 1,2-hexanediol, 1,2-pentanediol, p-hydroxyacetophenone, and hydrogenated lecithin. The appropriate components can be selected according to the specific comparative ratio.

[0103] Phase B raw materials are one or more of the following: glyceryl stearate citrate, polyglycerol-3-methyl glucoside distearate, sorbitan stearate, cetearyl alcohol, caprylic / capric triglyceride, and tocopheryl acetate. The appropriate selection can be made according to the specific comparative ratio components.

[0104] Preparation process: Phase A raw material is added to a beaker in sequence, stirred and dispersed evenly, and heated to 78°C to obtain an aqueous phase; Phase B raw material is added to another beaker in sequence, heated and stirred until completely dissolved, and heated to 78°C to obtain an oil phase; the oil phase is poured into the aqueous phase and homogenized for 3 minutes at 4000-8000 rpm using an IKA apparatus; then the mixture is slowly stirred and cooled in a water bath; the temperature is lowered to below 32°C to obtain a liquid crystal cream.

[0105] Compared with Example 1 of the Comparative Examples, the results of Comparative Examples 13-18 show that the single or combination of three hydrophilic emulsifiers is significantly weaker than the combination of all three. This is mainly reflected in three aspects: First, the average particle size of the prepared liquid crystal creams is between 7-9 μm, which is larger than the 3.22 μm of Example 1; second, the penetration-enhancing effect of the comparative examples on tocopheryl acetate is relatively weaker than that of Example 1, with a relative penetration rate of less than 10% after 8 hours, while the relative penetration rate of Example 1 can reach 16.73% after 8 hours; finally, the maximum skin penetration depth of the comparative examples after 8 hours is 90 μm, which is weaker than the 120 μm depth of Example 1.

[0106] It is evident that the combination of this patented solution can prepare liquid crystal creams smaller than 5µm, which have a good penetration-enhancing effect on both oil-soluble and water-soluble active ingredients. It is expected to achieve better skincare results by incorporating different active ingredients in the field of cosmetic skincare.

Claims

1. A liquid crystal cream with highly efficient penetration ability, characterized in that, Includes the following components by weight percentage: 0.15-3% lipophilic emulsifier, 1-6% long-chain fatty alcohols and esters, 0-20% humectant, 0-2% thickener, emollient, 0.1-1% preservative, 0-5% active ingredient, 0-15% oil, 0-0.5% chelating agent, 0.05-1% lecithin emulsifier, 0.4-2% anionic emulsifier, 0.1-3% polyglycerol emulsifier, and the remainder is deionized water; The lipophilic emulsifier is sorbitan stearate or glyceryl stearate; The long-chain fatty alcohols and esters are cetearyl alcohol, behenyl alcohol, or myristyl myristate. The lecithin emulsifier is hydrogenated lecithin and / or lysophosphatidylcholine; The anionic emulsifiers include one or more of the following: glyceryl stearate citrate, potassium cetyl phosphate, sodium stearoyl glutamate, sodium methylstearoyl taurate, sodium di(lauramide glutamine) lysine, and / or C20-22 alcohol phosphate. Polyglycerol emulsifiers include one or more of the following: polyglycerol-2 stearate, polyglycerol-10 stearate, polyglycerol-10 myristate, polyglycerol-3 methyl glucoside distearate, polyglycerol-4 laurate, polyglycerol-6 distearate, polyglycerol-6 octastearate, and / or polyglycerol-10 dioleate.

2. The method for preparing a liquid crystal cream with high penetration ability according to claim 1, characterized in that: Includes the following steps: 1) Stir and disperse deionized water, thickener, chelating agent, humectant, lecithin emulsifier, and preservative evenly, and heat to 75℃-85℃ to obtain the aqueous phase; 2) Heat and stir anionic emulsifiers, polyglycerol emulsifiers, lipophilic emulsifiers, long-chain fatty alcohols and esters, and oils until completely dissolved, and heat to 75℃-85℃ to obtain the oil phase; 3) Add the oil phase to the aqueous phase and homogenize it for 3-8 minutes at 4000rpm-8000rpm using a homogenizer, then slowly stir and cool it in a water bath. 4) Cool down to below 50℃, add the active ingredient, and stir to disperse evenly; 5) Continue stirring in the water bath and slowly cool down to below 32°C to obtain liquid crystal cream.

3. The application of the liquid crystal cream with high penetration ability as described in claim 1 in the preparation of cosmetics.

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