A sample analysis device

Abstract

A sample analysis device includes: a liquid preparation unit configured to obtain a sample and a reagent to prepare a liquid to be measured; a measurement unit configured to measure the liquid to be measured; a liquid injection mechanism configured to inject the liquid; and a controller configured to control at least the liquid injection mechanism. The liquid injection mechanism includes a power component, a switching component, a liquid pipeline, and a pressure relief switch. The power component is configured to provide power for the liquid to flow in the liquid pipeline. The switching component includes a first port, a second port, and a third port. The liquid pipeline includes a first branch, a second branch, a third branch, and a pressure relief branch. The second branch has a shunt node at a first height. One end of the pressure relief branch is connected to the shunt node, and the other end is configured to communicate with the atmosphere. The second branch can be shunted to the pressure relief branch through the shunt node. The pressure relief switch is arranged on the pressure relief branch and can be opened and closed to open and close the pressure relief branch. The application can improve the liquid injection accuracy of the liquid injection mechanism.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of in vitro diagnosis, in particular to a sample analysis device. BACKGROUND

[0002] A sample analysis device, such as a biochemical analyzer and an immunoassay analyzer, is an instrument for analyzing and measuring a sample, which is generally connected to a liquid injection needle through a liquid pipeline to discharge a sample, a reagent, a substrate or a cleaning liquid and the like. The sample analysis device is generally connected to multiple pipelines through a switching device for sucking or discharging liquid. When the switching device switches the pipeline connection, some pipelines may be back-sucked and some pipelines may be liquid-discharged, which affects the accuracy of the liquid injection amount and causes the precision and reliability of the system to decrease.

[0003] Therefore, it is a problem to be solved. SUMMARY

[0004] In view of the above problems, the present application provides a sample analysis device, which is described in detail below.

[0005] According to a first aspect, a sample analysis device is provided in an embodiment, comprising:

[0006] a to-be-tested liquid preparation unit configured to obtain a sample and a reagent to prepare a to-be-tested liquid;

[0007] a measurement unit configured to measure the to-be-tested liquid;

[0008] a liquid injection mechanism configured to inject liquid; and

[0009] a controller configured to control at least the liquid injection mechanism; wherein:

[0010] The liquid injection mechanism comprises a power component, a switching component, a liquid pipeline and a pressure relief switch. The power component is configured to provide power for the flow of liquid in the liquid pipeline. The switching component comprises a first port, a second port and a third port. The liquid pipeline comprises a first branch, a second branch, a third branch and a pressure relief branch. One end of the first branch is connected to the first port of the switching component, and the other end of the first branch is capable of communicating with the atmosphere and is arranged at a first height. One end of the second branch is connected to the second port of the switching component, and the other end of the second branch is capable of communicating with the atmosphere and is arranged at a second height lower than the first height. One end of the third branch is connected to the third port of the switching component. The switching component is capable of switching the third port to communicate with one of the first port and the second port, so that the third branch communicates with the first branch or the second branch.

[0011] The second branch has a shunt node, and the shunt node is located at a first height; one end of the pressure relief branch is connected with the shunt node, and the other end is used for communicating with the atmosphere; the second branch can shunt to the pressure relief branch through the shunt node; a pressure relief switch is arranged on the pressure relief branch, and the pressure relief switch can be opened and closed to open and close the pressure relief branch;

[0012] In a case where the switching component is currently in communication between the third port and the second port, the controller controls the pressure relief switch to open before controlling the switching component to switch the third port to be in communication with the first port; and / or, in a case where the switching component is currently in communication between the third port and the first port, the controller controls the pressure relief switch to open before controlling the switching component to switch the third port to be in communication with the second port.

[0013] In an embodiment, the controller controls the pressure relief switch to open before controlling the switching component to switch, including: the controller controls the pressure relief switch to open within 50 ms to 1 s or 50 ms to 100 ms before controlling the switching component to switch.

[0014] In an embodiment, the controller controls the pressure relief switch to close within 0 s to 1 s or 0 s to 100 ms after controlling the switching component to switch.

[0015] In an embodiment, the switching component is a three-way electromagnetic valve.

[0016] In an embodiment, the pressure relief switch is a two-way electromagnetic valve.

[0017] In an embodiment, the liquid injection mechanism further comprises a shunt component, and the shunt component is arranged on the second branch and in communication with the second branch to form the shunt node.

[0018] In an embodiment, the shunt component is a three-way joint.

[0019] In an embodiment, the height of the pressure relief switch is higher than the height of the shunt node.

[0020] In an embodiment, the other end of the first branch is a liquid injection end for magnetic separation and cleaning.

[0021] In an embodiment, the liquid injection mechanism further comprises a preheating component; under the action of the power provided by the power component, the liquid pipeline can obtain cleaning liquid from a cleaning liquid providing component and transmit the cleaning liquid through the preheating component to heat the cleaning liquid, and the heated cleaning liquid reaches the third port of the switching component through the third branch:

[0022] In the first state, the third port of the switching component is in communication with the second port, and the cleaning liquid is transmitted to the second branch through the communicated third port and second port, and the second branch returns the cleaning liquid of the third branch to the first position, so that the cleaning liquid can pass through the preheating component again and enter the third branch;

[0023] The switching component is in the second state, and the third port of the switching component is in communication with the first port, and the cleaning liquid is transmitted to the first branch through the communicated third port and the first port, and is discharged through the first branch.

[0024] In an embodiment, the second branch is connected to the preheating component.

[0025] When the first branch is in the non-injection state, the controller controls the switching component to be in the first state, and controls the power component to provide power, so that the cleaning liquid is transmitted to the second branch through the third branch, and flows back to the first position through the second branch, and can pass through the preheating component again and enter the third branch;

[0026] When the first branch is in the injection state, the controller controls the switching component to be in the second state, and controls the power component to provide power, so that the cleaning liquid is transmitted to the first branch through the third branch, and is discharged through the first branch.

[0027] In an embodiment, the other end of the second branch is used to connect the cleaning liquid providing component, and the cleaning liquid providing component is in communication with the atmosphere.

[0028] In an embodiment, the liquid pipeline includes a plurality of first branches.

[0029] Each first branch corresponds to a switching component, a second branch, a third branch, and a pressure relief switch; or each first branch corresponds to a switching component and a third branch, and all the first branches share a second branch and a pressure relief switch.

[0030] According to the sample analysis device of the above-mentioned embodiment, when the third port of the switching component is in communication with the second port, the controller controls the pressure relief switch to be opened before controlling the switching component to switch the third port to be in communication with the first port; and / or when the third port of the switching component is in communication with the first port, the controller controls the pressure relief switch to be opened before controlling the switching component to switch the third port to be in communication with the second port. After the pressure relief through the pressure relief branch, the third branch is in communication with the first branch or the second branch, which prevents the pressure difference due to the difference between the first height and the second height, avoids the back suction after the first branch is in communication with the third branch, and avoids the liquid discharge after the second branch is in communication with the third branch, which is beneficial to improve the liquid discharge accuracy and reliability of the sample analysis device. BRIEF DESCRIPTION OF DRAWINGS

[0031] Figure 1 A structure diagram of an injection mechanism is provided for an embodiment;

[0032] Figure 2 A structure diagram of an injection mechanism is provided for an embodiment;

[0033] Figure 3A schematic diagram of the structure of a sample analysis device provided in one embodiment;

[0034] Figure 4 This is a schematic diagram of the structure of the liquid preparation unit provided in one embodiment;

[0035] Figure 5 A schematic diagram of the structure of a sample analysis device provided in one embodiment;

[0036] Figure 6 A schematic diagram of the structure of a sample analysis device provided in one embodiment;

[0037] Figure 7 A schematic diagram of the liquid injection mechanism provided in one embodiment;

[0038] Figure 8 A schematic diagram of the liquid injection mechanism provided in one embodiment;

[0039] Figure 9 A schematic diagram of the liquid injection mechanism provided in one embodiment;

[0040] Figure 10 A schematic diagram of the liquid injection mechanism provided in one embodiment;

[0041] Figure 11 A schematic diagram of the liquid injection mechanism provided in one embodiment;

[0042] Figure 12 A schematic diagram of the liquid injection mechanism provided in one embodiment;

[0043] Figure 13 This is a schematic diagram of the liquid injection mechanism provided in one embodiment. Detailed Implementation

[0044] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments. Similar elements in different embodiments are referred to by associated similar element reference numerals. In the following embodiments, many details are described to facilitate a better understanding of the present application. However, those skilled in the art will readily recognize that some features may be omitted in different situations, or may be replaced by other elements, materials, or methods. In some cases, certain operations related to the present application are not shown or described in the specification. This is to avoid obscuring the core parts of the present application with excessive description. For those skilled in the art, detailed description of these related operations is not necessary; they can fully understand the related operations based on the description in the specification and general technical knowledge in the art.

[0045] In addition, features described in the specification, operations or characteristics can be combined in any appropriate manner to form various embodiments. Meanwhile, the steps or actions in the method description can also be sequentially changed or adjusted in a manner obvious to those skilled in the art. Therefore, the various sequences in the specification and drawings are only for the purpose of clearly describing a certain embodiment, and do not mean that the sequence is necessary, unless otherwise stated that a certain sequence must be followed.

[0046] The serial numbers of components in the text, such as "first", "second", etc., are only used to distinguish the described objects, and do not have any sequence or technical meaning. The "connection" and "coupling" in the application include direct and indirect connection (coupling) unless otherwise specified.

[0047] For sample analysis devices, at least the sample and reagent are mixed to form a reaction liquid, and then the project detection is carried out, therefore, the sample analysis device at least includes a sample liquid injection mechanism 20 and a reagent liquid injection mechanism 30, and the sample analysis device involving magnetic separation and cleaning can further include a magnetic separation unit 60. The sample liquid injection mechanism 20, the reagent liquid injection mechanism 30 and the magnetic separation unit 60 respectively include their own liquid injection mechanisms for sucking and dispensing liquids such as samples, reagents and cleaning liquids. For each sample test, the liquid volume of the liquid discharged into the reaction cup needs to meet the preset accuracy requirement, otherwise it will affect the accuracy of the sample analysis device measurement.

[0048] The applicant found that the liquid injection mechanism of the sample analysis device is not accurate in some cases, and some liquid injection needles inject less liquid, and some liquid injection needles appear liquid spitting phenomenon. The applicant further found that, for example, when the first branch 6241 and the second branch 6242 of the liquid pipeline 624 of the liquid injection mechanism are connected to the ports of different heights, when the third branch 6243 is switched to be connected to the first branch 6241 and the second branch 6242 respectively, the port of the first branch 6241 at the high position will appear liquid back suction phenomenon, and the port of the second branch 6242 at the low position will appear liquid spitting phenomenon. Figure 1

[0049] The applicant analyzed that this is because the ports of the first branch 6241 and the second branch 6242 connected to the atmosphere are of different heights, and the height difference ΔH causes a pressure difference inside the pipeline. When the switching component 623 switches the third branch 6243 to be connected to the first branch 6241 and the second branch 6242 respectively, the pressure difference inside the pipeline causes the two branches to appear back suction and liquid spitting phenomenon. For this problem, for example, as shown in FIG. 6, the liquid injection mechanism 600 further includes a liquid level sensor 630, and the liquid level sensor 630 is connected to the switching component 623, and the switching component 623 is controlled by the liquid level sensor 630. Figure 2 ​As shown, the applicant can offset the problem of liquid spitting and back suction caused by the height difference between the first branch 6241 and the second branch 6242 by setting a buffer container 626 communicating with the atmosphere on the second branch 6242. However, if the capacity of the buffer container 626 is large, it will occupy a large space volume and is not easy to set in the sample analysis device; if the capacity is small, the risk of overflow is high.

[0050] In some embodiments of the present application, by setting a flow splitting node at a position where the port of the second branch 6242 and the port of the first branch 6241 communicating with the atmosphere are at the same height, setting a pressure relief branch 6244 on the flow splitting node, and controlling the pressure relief branch 6244 to open or close through the pressure relief switch 620, cooperating with the switching component 623 to switch the third branch 6243 to communicate with the first branch 6241 or the second branch 6242, controlling the pressure relief branch 6244 to open for pressure relief before the third branch 6243 communicates with the first branch 6241 or the second branch 6242, eliminating the pressure difference caused by the height difference between the first branch 6241 and the second branch 6242, and preventing the phenomenon of liquid spitting or back suction when the third branch 6243 communicates with the first branch 6241 or the second branch 6242, the accuracy of the liquid injection amount of the sample analysis device is improved, and the measurement accuracy of the sample analysis device is improved.

[0051] Next, the sample analysis device will be described.

[0052] Please refer to Figure 3 The sample analysis device of some embodiments can include a sample liquid preparation unit 100, a measurement unit 70, a liquid injection mechanism 200, and a controller 80, which will be described in detail below.

[0053] The sample liquid preparation unit 100 is used to obtain a sample and a reagent to prepare a sample liquid. As Figures 4 to 6 As shown, the sample liquid preparation unit 100 of some embodiments can include a sample carrying unit 10, a reagent carrying unit 40, and a reaction unit 50, which will be described in detail below.

[0054] The sample carrying unit 10 is used to carry a sample. In some examples, the sample carrying unit 10 can include a sample delivery module (SDM) and a front-end track; in other examples, the sample carrying unit 10 can also be a sample disc, which can hold multiple sample tubes. The sample disc can schedule samples to the corresponding positions, such as the position for the sample injection mechanism 20 to suck the sample, by rotating its disc structure.

[0055] The reagent carrying part 40 is used to carry reagents. In some embodiments, the reagent carrying part 40 can be a reagent disc arranged in a disc structure, having a plurality of positions for carrying reagent containers, and the reagent carrying part 40 can rotate and drive the reagent containers carried thereby to rotate, so as to rotate the reagent containers to a specific position, for example, a position for reagent suction by the reagent injection mechanism 30. The number of reagent carrying parts 40 can be one or more.

[0056] The reaction part 50 has at least one placement position for placing a reaction cup and incubating a reaction liquid in the reaction cup, the reaction liquid being obtained at least by mixing a sample and a reagent. For example, the reaction part 50 can be a reaction disc arranged in a disc structure, having one or more placement positions for placing reaction cups, and the reaction disc can rotate and drive the reaction cups in the placement positions to rotate, so as to schedule the reaction cups in the reaction disc and incubate the reaction liquid in the reaction cups. The sample injection mechanism 20 has a sample injection position corresponding to a reaction cup, and the sample needle moves to the sample injection position to discharge a sample liquid to the reaction cup corresponding to the sample injection position.

[0057] The above is a description of the preparation part 100 of the liquid to be tested.

[0058] The measurement part 70 is used to measure the liquid to be tested. For example, the measurement can be performed in an optical measurement manner, the luminescence intensity of the reaction liquid to be tested is detected, and the concentration of the component to be tested in the sample is calculated through a calibration curve. Other test manners can also be used, and the sample analysis device provided in the present application is not limited to a specific sample test manner.

[0059] The injection mechanism 200 is used for injection. The sample analysis device can include one or more of the sample injection mechanism 20, the reagent injection mechanism 30, the substrate injection mechanism, and the magnetic separation injection mechanism 62, and the injection mechanism 200 provided in the present application can be applied to one or more of them. The injection mechanism 200 will be described in detail below.

[0060] As Figure 7 With Figure 8As shown, the liquid injection mechanism 200 can include a power component 621, a switching component 623, a liquid pipeline 624, and a pressure relief switch 620; the power component 621 is configured to provide power for liquid flowing in the liquid pipeline 624, the switching component 623 includes a first port, a second port, and a third port, the liquid pipeline 624 includes a first branch 6241, a second branch 6242, a third branch 6243, and a pressure relief branch 6244, one end of the first branch 6241 is connected to the first port of the switching component 623, the other end of the first branch 6241 is capable of communicating with the atmosphere and is arranged at a first height, one end of the second branch 6242 is connected to the second port of the switching component 623, the other end of the second branch 6242 is capable of communicating with the atmosphere and is arranged at a second height lower than the first height, one end of the third branch 6243 is connected to the third port of the switching component 623; the switching component 623 is capable of switching the third port to communicate with one of the first port and the second port, so that the third branch 6243 communicates with the first branch 6241 or the second branch 6242.

[0061] The second branch 6242 has a shunt node at the first height; one end of the pressure relief branch 6244 is connected to the shunt node, and the other end is configured to communicate with the atmosphere; the second branch 6242 is capable of shunting to the pressure relief branch 6244 through the shunt node; the pressure relief branch 6244 is provided with the pressure relief switch 620, which is capable of being opened and closed to open and close the pressure relief branch 6244.

[0062] As can be seen, after the pressure relief branch 6244 is opened by the pressure relief switch 620, the shunt node and the other end of the first branch 6241 are at the same height, the pressures at both ends of the switching component 623 are the same, and the pressure difference can be eliminated; before switching of the switching component 623 is needed, pressure relief can be performed through the pressure relief branch 6244; under the premise of eliminating the pressure difference, the first branch 6241 will not suck liquid, and the second branch 6242 will not spit liquid.

[0063] In some embodiments, as shown in Figure 8 The height of the pressure relief switch 620 is higher than the height of the shunt node, and the pressure relief switch 620 is arranged at the middle or the end of the pressure relief branch 6244. When the switching component 623 communicates the second branch 6242 with the third branch 6243, liquid flows through the shunt node, the pressure relief switch 620 is arranged at a height higher than the shunt node, and after the pressure relief switch 620 is opened, liquid will not flow out through the pressure relief branch 6244, and there is no problem of overflow.

[0064] In some embodiments, as shown in Figure 8As shown, the injection mechanism 200 may further include a diversion component 627, which is disposed on and connected to the second branch 6242 to form a diversion node. The diversion component 627 may be a diversion component already in use in existing sample analysis devices.

[0065] For example, the flow divider 627 can be a tee connector. The tee connector can be used for flow division and convergence, and can be matched with the liquid pipeline 624. It is easy to install on the second branch 6242 and is convenient to operate.

[0066] In some embodiments, such as Figure 5 , Figure 6 and Figure 9 As shown, the sample analysis device may include a magnetic separation unit 60, which may include at least a magnetic separation disk 61 and a magnetic separation liquid injection mechanism 62. The liquid injection mechanism 200 provided in this application may serve as the magnetic separation liquid injection mechanism 62 of the magnetic separation unit 60, and the other end of the first branch 6241 is the liquid injection end for magnetic separation cleaning.

[0067] In some embodiments, such as Figure 5 , Figure 6 and Figure 9 As shown, the sample analysis device may include a magnetic separation unit 60, which may include at least a magnetic separation disk 61 and a magnetic separation liquid injection mechanism 62. The liquid injection mechanism 200 provided in this application can serve as the magnetic separation liquid injection mechanism 62 of the magnetic separation unit 60. The other end of the second branch 6242 is used to connect to the cleaning fluid supply component 625, which is in communication with the atmosphere. The cleaning fluid can be drawn from the cleaning fluid supply component 625 through the other end of the second branch 6242, or it can be returned to the cleaning fluid supply component 625 through the other end of the second branch 6242.

[0068] In these embodiments, when the liquid injection mechanism 200 needs to discharge cleaning fluid, after depressurization through the pressure relief branch 6244, the second branch 6242 and the third branch 6243 are connected, and the power component 621 draws cleaning fluid through the second branch 6242 or through other pipelines; after depressurization again through the pressure relief branch 6244, the first branch 6241 and the third branch 6243 are connected, and the power component 621 discharges cleaning fluid through the first branch 6241. The pressure relief branch 6244 depressurizes before liquid intake and discharge, ensuring the accuracy of the intake and discharge volumes, ensuring the volume of cleaning fluid discharged into the reaction cup meets requirements, and ensuring the effectiveness of magnetic separation cleaning. When the first branch 6241 is not in the liquid injection state, the cleaning fluid can also be returned to the cleaning fluid supply component 625 through the second branch 6242, forming a circulating flow.

[0069] In some embodiments, such as Figure 10and Figure 11 As shown, the liquid pipeline 624 may include multiple first branches 6241; each first branch 6241 corresponds to a switching component 623, a second branch 6242, a third branch 6243, and a pressure relief switch 620; or, each first branch 6241 corresponds to a switching component 623 and a third branch 6243, and each first branch 6241 shares a second branch 6242 and a pressure relief switch 620. When the liquid injection mechanism 200 can serve as the magnetic separation liquid injection mechanism 62 of the magnetic separation unit 60, the multiple first branches 6241 are the liquid injection ends for multi-stage magnetic cleaning. When the multiple first branches 6241 are used for simultaneous or sequential liquid injection, they can share a second branch 6242 and a pressure relief switch 620, saving the space occupied by the multiple second branches 6242.

[0070] In some embodiments, the switching component 623 can be a three-way solenoid valve, or the switching component 623 can be formed by combining multiple two-way solenoid valves. The three-way solenoid valve is a commonly used valve to realize the function of the switching component 623. In fact, this application does not limit the specific implementation of the switching component 623; and / or, the pressure relief switch 620 can be a two-way solenoid valve or other electrically controllable switches.

[0071] The above is a description of the sample analysis device. The following explains how the switching component 623 and the pressure relief switch 620 are controlled.

[0072] In some embodiments, with Figure 8 Taking the injection mechanism 200 as an example, the controller 80 is used to control at least the injection mechanism 200; wherein: when the third port of the switching component 623 is currently connected to the second port, the controller 80 controls the pressure relief switch 620 to open before controlling the switching component 623 to switch the third port to connect with the first port; and / or, when the third port of the switching component 623 is currently connected to the first port, the controller 80 controls the pressure relief switch 620 to open before controlling the switching component 623 to switch the third port to connect with the second port. After controlling the switching component 623 to switch, the controller 80 controls the pressure relief switch 620 to close, and then controls the power component 621 to drive the liquid to flow in the liquid pipeline 624 to achieve liquid suction or discharge.

[0073] In some embodiments, the controller 80 first controls the pressure relief switch 620 to open, including: the controller 80 controls the pressure relief switch 620 to open within 50ms to 1s or 50ms to 100ms before the control switching component 623 switches.

[0074] In some embodiments, the controller 80 controls the pressure relief switch 620 to close within 0s to 1s or 0s to 100ms after the control switching component 623 is switched.

[0075] In these embodiments, the controller 80 controls the switching component 623 to work in cooperation with the pressure relief switch 620. In principle, the shorter the time required for the pressure relief switch 620 to complete pressure relief, the better, and the pressure relief switch 620 needs to be determined according to the injection period of the injection mechanism 200 when to open and close to ensure that the pressure relief does not affect the normal work of the injection mechanism 200.

[0076] It can be seen that, taking the switching component 623 as a three-way electromagnetic valve and the pressure relief switch 620 as a two-way electromagnetic valve as an example, the entire control process only needs to reasonably cooperate the on-off of the pressure relief switch 620 of the pressure relief branch 6244 with the switching of the three-way valve, which can eliminate the problem of pressure difference in the switching process of the three-way valve, so that the injection precision of the injection mechanism 200 is guaranteed. The injection mechanism 200 provided by the embodiments of the present application realizes the adjustment of the pressure state inside the liquid pipeline 624 through the pressure relief branch 6244, and has simple overall structure and convenient control. At the same time, it can include the original structure of the sample analysis device, and can be improved and applied on the existing injection mechanisms such as the sample injection mechanism 20, the reagent injection mechanism 30, and the magnetic separation injection mechanism 62.

[0077] The sample analysis device in some embodiments can include a magnetic separation unit 60, and the injection mechanism 200 is a magnetic separation injection mechanism 62 of the magnetic separation unit 60. At this time, the end of the first branch 6241 has an injection needle for injection, and for the case that the temperature of the cleaning liquid of the magnetic separation unit 60 is lower than the test temperature of the reaction liquid, as shown in FIG. 6B, the injection mechanism 200 can further include a preheating component 622; under the power provided by the power component 621, the liquid pipeline 624 can obtain the cleaning liquid from a cleaning liquid providing component 625 and transmit the cleaning liquid through the preheating component 622 to heat the cleaning liquid. The heated cleaning liquid then reaches the third port of the switching component 623 through the third branch 6243. At this time, the injection mechanism 200 has two working states of a non-injection state and an injection state, and the switching component 623 corresponds to two working states. Figure 12

[0078] ​The applicant further found that, after adding the preheating component 622, the temperature consistency of the cleaning liquid between multiple discharges can be ensured when the cleaning liquid is continuously discharged. However, if the time interval between two discharges of the cleaning liquid is different, the cleaning liquid located in the heating area of the preheating component 622 is heated for different time, resulting in different temperatures of the cleaning liquid discharged twice. If the time interval is too long, the cleaning liquid located in the heating area of the preheating component 622 is heated for a long time, and the temperature of the cleaning liquid will not only be too high, but also bubbles or crystals will be generated. The above problems will all affect the accuracy of the detection result. In addition, the temperature of the cleaning liquid in the pipeline between the preheating component 622 and the liquid injection needle will be affected by the environment and will decrease. If the liquid is not discharged for a long time, the cleaning liquid remaining in the liquid pipeline 624 will have a large heat loss, and the temperature of the cleaning liquid discharged into the reaction cup next time will also be low. It can be seen that the cleaning liquid in the liquid pipeline 624 will have problems of local temperature being too high and local temperature being too low.

[0079] The applicant found that the main problem caused by the above-mentioned addition of the preheating component 622 is that, when the cleaning liquid in the magnetic separation and liquid injection mechanism 62 is in a non-liquid injection state, the cleaning liquid located in the heating area of the preheating component 622 does not flow, and the cleaning liquid at other positions of the liquid pipeline 624 has a heat loss. The time of maintaining the non-liquid injection state is different, the heat loss of the cleaning liquid in the liquid pipeline 624 between the preheating component 622 and the liquid injection needle is different, the temperature change is different, and the temperature of the cleaning liquid discharged by the magnetic separation and liquid injection mechanism 62 during the next liquid injection is different. Therefore, in some embodiments of the present application, by keeping the cleaning liquid flowing in the liquid pipeline 624 when the liquid injection mechanism 200 is in a non-liquid injection state, the cleaning liquid in the liquid pipeline 624 is continuously updated, the accurate control of the temperature of the cleaning liquid is realized, the problem caused by the preheating component 622 is solved, the temperature consistency of the cleaning liquid discharged by the magnetic separation and liquid injection mechanism 62 during each liquid injection is ensured, and the accuracy of the detection result of the sample analysis device is ensured.

[0080] Corresponding to the non-liquid injection state, the switching component 623 is in the first state, the third port and the second port of the switching component 623 are in communication, the cleaning liquid is transmitted to the second branch 6242 through the communicated third port and second port, the second branch 6242 returns the cleaning liquid in the third branch 6243 to the first position, so that the cleaning liquid can pass through the preheating component 622 again and enter the third branch 6243. At this time, the second branch 6242 and the third branch 6243 form a circulating loop, the cleaning liquid can be continuously updated and heated by the preheating component 622 under the action of backflow, so as to reduce the heat loss caused by the low temperature of the environment and realize the effect of backflow temperature control of the cleaning liquid. As shown in Figure 12 the first position can be the position of the cleaning liquid providing component 625, as shown in Figure 13The third branch 6243 can be a specific position of the third branch 6243, and the feature position can be between the preheating component 622 and the power component 621.

[0081] In the corresponding injection state, the switching component 623 is in the second state, and the third port is in communication with the first port. The cleaning liquid is transmitted to the first branch 6241 through the communicated third port and first port, and is discharged through the first branch 6241.

[0082] In some embodiments, the controller 80 controls the switching state of the switching component 623 according to the working state of the injection mechanism 200, which will be described in detail below.

[0083] When the first branch 6241 is in a non-injection state, the controller 80 controls the switching component 623 to be in the first state, and controls the power component 621 to provide power, so that the cleaning liquid is transmitted to the second branch 6242 through the third branch 6243 and flows back to the first position through the second branch 6242, and can pass through the preheating component 622 and enter the third branch 6243 again. When the third port of the switching component 623 is in communication with the first port, the controller 80 controls the switching component 623 to switch the third port to be in communication with the second port, and then controls the pressure relief switch 620 to be opened. After the controller 80 controls the switching of the switching component 623, the controller 80 controls the pressure relief switch 620 to be closed.

[0084] When the first branch 6241 is in an injection state, the controller 80 controls the switching component 623 to be in the second state, and controls the power component 621 to provide power, so that the cleaning liquid is transmitted to the first branch 6241 through the third branch 6243, and is discharged through the first branch 6241. When the third port of the switching component 623 is in communication with the second port, the controller 80 controls the switching component 623 to switch the third port to be in communication with the first port, and then controls the pressure relief switch 620 to be opened. After the controller 80 controls the switching of the switching component 623, the controller 80 controls the pressure relief switch 620 to be closed.

[0085] In these embodiments, the liquid injection mechanism 200 is provided with the switching component 623 and the pressure relief branch 6244, and the controller 80 switches the liquid pipeline 624 between the non-injection state (backflow state) and the injection state according to the working state of the liquid injection mechanism 200, so that the cleaning liquid in the third branch 6243 is always in a circulating flow state, the second branch 6242 backflows the cleaning liquid in the third branch 6243 to the first position, so that the cleaning liquid can pass through the preheating component 622 again and enter the third branch 6243, and the cleaning liquid in the third branch 6243 is backflowed to the first position by the second branch 6242, so that the cleaning liquid can pass through the preheating component 622 again and enter the third branch 6243, solving the problem of heat loss caused by low temperature environment, thereby realizing precise temperature control of the magnetic separation cleaning liquid of the sample analysis device, reducing the interference of temperature change factors on the chemical reaction system, and having important significance for improving the specificity, repeatability and precision of the detection system of the immunochemical luminescence analyzer, especially for the detection of clinical temperature-sensitive projects, ensuring the consistency of the temperature of the injected cleaning liquid in the magnetic separation process, and playing a significant role in improving the accuracy of the detection results of clinical projects.

[0086] As described above, the temperature of the cleaning liquid in the pipeline between the preheating component 622 and the liquid injection needle (corresponding to the third branch 6243 and the first branch 6241) is affected by the environment, and there is heat loss due to heat exchange with air. The applicant also found that the second branch 6242 can be used to backflow the cleaning liquid in the third branch 6243, but the cleaning liquid in the first branch 6241 is not backflowed to the second branch 6242, and the temperature of the cleaning liquid in the first branch 6241 is still affected by the environment; and one end of the first branch 6241 is connected to the atmosphere, and the cleaning liquid at the end also has the problem of evaporation, which affects the liquid volume of the cleaning liquid discharged the next time in a long time non-injection state. In order to further improve the detection accuracy of the sample analysis device and reduce the influence of temperature change of the cleaning liquid in the first branch 6241, some embodiments of the present application perform back-suction processing on the cleaning liquid in the first branch 6241 to solve the above problems, which will be described in detail below.

[0087] In some embodiments, before the first branch 6241 is switched from the injection state to the non-injection state: the controller 80 controls the power component 621 to back-suck part or all of the cleaning liquid in the first branch 6241 to the third branch 6243, controls the pressure relief branch 6244 to open for pressure relief, and then controls the switching component 623 to switch from the second state to the first state. That is, part or all of the cleaning liquid in the first branch 6241 is back-sucked to the third branch 6243, and then backflows to the second branch 6242. During the back-suction process, a small amount of cleaning liquid may still remain on the wall of the first branch 6241, but after the back-suction processing, the temperature influence of the cleaning liquid in the first branch 6241 on the next injection can be greatly reduced.

[0088] The foregoing detailed description has been presented for purposes of clarity and description. However, various modifications and changes can be made to the exemplary embodiments described herein without departing from the scope of the disclosure. For example, various steps and components of the embodiments described herein can be implemented in different manners (e.g., one or more steps can be deleted, modified, or combined with other steps) depending on the particular application or any number of cost functions associated with the operation of the system.

[0089] While the principles of the application have been described above in connection with various embodiments, it is to be understood that numerous modifications and applications can be made without departing from the principles of the disclosure. For example, while the principles of the application have been illustrated using various embodiments, many modifications in the details of construction, arrangement, proportions, elements, materials, and components used in the practice of the application can be made without departing from the principles of the disclosure. Such modifications and other changes or modifications are intended to be included within the scope of the disclosure.

[0090] The foregoing detailed description has been presented for purposes of clarity and description. However, various modifications and changes can be made to the exemplary embodiments described herein without departing from the scope of the disclosure. For example, various steps and components of the embodiments described herein can be implemented in different manners (e.g., one or more steps can be deleted, modified, or combined with other steps) depending on the particular application or any number of cost functions associated with the operation of the system.

[0091] Those skilled in the art will recognize that many modifications can be made to the details of the above-described embodiments without departing from the underlying principles of the present application. The scope of the present application should, therefore, be determined only by the following claims.

Claims

1. A sample analysis device, characterized in that, include: The test liquid preparation unit is used to acquire samples and reagents to prepare the test liquid; The measuring unit is used to measure the liquid to be tested; The liquid injection mechanism is used for liquid injection. as well as, A controller is configured to control at least the injection mechanism; wherein: The liquid injection mechanism includes a power component, a switching component, a liquid pipeline, and a pressure relief switch. The power component provides power for the liquid to flow in the liquid pipeline. The switching component includes a first port, a second port, and a third port. The liquid pipeline includes a first branch, a second branch, a third branch, and a pressure relief branch. One end of the first branch is connected to the first port of the switching component, and the other end of the first branch is open to the atmosphere and positioned at a first height. One end of the second branch is connected to the second port of the switching component, and the other end of the second branch is open to the atmosphere and positioned at a second height lower than the first height. One end of the third branch is connected to the third port of the switching component. The switching component can switch the third port to connect with either the first port or the second port, so that the third branch is connected to either the first branch or the second branch. The second branch has a diversion node located at the first altitude; one end of the pressure relief branch is connected to the diversion node, and the other end is used to communicate with the atmosphere; the second branch can divert water to the pressure relief branch through the diversion node; the pressure relief branch is equipped with a pressure relief switch, which can be opened and closed to open and close the pressure relief branch. When the switching component is currently connected to the second port, the controller controls the pressure relief switch to open before switching the switching component to connect the third port to the first port; and / or, when the switching component is currently connected to the first port, the controller controls the pressure relief switch to open before switching the switching component to connect the third port to the second port.

2. The sample analysis device as described in claim 1, characterized in that: The controller first controls the pressure relief switch to open, including: the controller controls the pressure relief switch to open within 50ms to 1s or 50ms to 100ms before controlling the switching component to switch.

3. The sample analysis device as described in claim 2, characterized in that, The controller controls the pressure relief switch to close within 0s to 1s or 0s to 100ms after controlling the switching component to switch.

4. The sample analysis apparatus as described in claim 1, characterized in that, The switching component is a three-way solenoid valve.

5. The sample analysis apparatus as described in claim 1, characterized in that, The pressure relief switch is a two-way solenoid valve.

6. The sample analysis apparatus as described in claim 1, characterized in that, The injection mechanism further includes a diversion component, which is disposed on the second branch and connected to the second branch to form the diversion node.

7. The sample analysis apparatus as described in claim 6, characterized in that, The diversion component is a tee connector.

8. The sample analysis apparatus as described in claim 1 or 6, characterized in that, The height of the pressure relief switch is higher than the height of the shunt node.

9. The sample analysis apparatus as described in claim 1, characterized in that, The other end of the first branch is the liquid injection end for magnetic separation cleaning.

10. The sample analysis apparatus as described in claim 9, characterized in that, The liquid injection mechanism also includes a preheating component; under the power provided by the power component, the liquid pipeline can obtain cleaning fluid from a cleaning fluid supply component and transmit it through the preheating component to heat the cleaning fluid. The heated cleaning fluid then reaches the third port of the switching component through the third branch. In the first state, the switching component has its third port connected to its second port. The cleaning fluid is transmitted to the second branch through the connected third and second ports. The second branch returns the cleaning fluid from the third branch to the first position so that the cleaning fluid can pass through the preheating component again and enter the third branch. In the second state, the switching component has its third port connected to the first port. The cleaning fluid is transmitted to the first branch through the connected third port and the first port, and is drained through the first branch.

11. The sample analysis apparatus as described in claim 10, characterized in that: When the first branch is in a non-injection state, the controller controls the switching component to be in the first state and controls the power component to provide power so that the cleaning fluid is transmitted through the third branch to the second branch and flows back to the first position through the second branch, and can pass through the preheating component again and enter the third branch. When the first branch is in the state of performing liquid injection, the controller controls the switching component to be in the second state and controls the power component to provide power so that the cleaning fluid is transmitted to the first branch through the third branch and drained through the first branch.

12. The sample analysis apparatus as described in claim 1, characterized in that, The other end of the second branch is used to connect to a cleaning fluid supply component, which is in communication with the atmosphere.

13. The sample analysis apparatus as described in claim 1, 6, 9, 10, or 11, characterized in that, The liquid pipeline includes multiple first branch lines; Each of the first branches corresponds to one switching component, one second branch, one third branch, and one pressure relief switch; or, each of the first branches corresponds to one switching component and one third branch, and each of the first branches shares one second branch and one pressure relief switch.

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