A method for preserving traditional Chinese medicinal materials
By placing Chinese medicinal materials in a microwave-ultrasound composite field for synergistic treatment and sealing them for preservation, the problem of easy loss of effective components during the preservation of Chinese medicinal materials is solved, and the stability of effective components and preservation time are improved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- BEIJING ZHISHENTANG PHARM CO LTD
- Filing Date
- 2023-12-14
- Publication Date
- 2026-07-24
AI Technical Summary
The effective components of Chinese medicinal materials are easily lost during the preservation process, which leads to a reduction in efficacy and may cause harm to the human body. Current technology does not effectively utilize microwave and ultrasound combined technology for preservation.
Chinese medicinal materials are placed in a microwave-ultrasound composite field under specific conditions for microwave-ultrasound synergistic treatment and then sealed for preservation. The treatment parameters include microwave power of 110-180W, ultrasonic power of 720-950W, treatment time of 20-40s, and sealed preservation temperature of 5-25℃.
This method significantly improves the stability of active ingredients in Chinese medicinal materials during preservation, extends the preservation time, and provides a new method for preserving Chinese medicinal materials.
Smart Images
Figure BDA0004607758180000071
Abstract
Description
Technical Field
[0001] This application relates to the field of traditional Chinese medicine preservation technology, and in particular to a method for preserving traditional Chinese medicine. Background Technology
[0002] Traditional Chinese medicinal herbs often undergo a long storage process from harvesting to processing into finished medicines. Improper storage can lead to the loss and destruction of the herbs' components, especially the active ingredients, resulting in reduced efficacy, potential harm to human health, economic losses, and material waste. Therefore, proper storage of traditional Chinese medicinal herbs is crucial to ensuring the stability of their quality.
[0003] Currently, ultrasonic and microwave technologies are widely used in the processing of Chinese medicinal materials. For example, in the extraction and processing of Chinese medicinal materials, they can significantly increase the content of effective components in the extracts. However, there are no reports in the existing technology on the application of microwave-ultrasonic synergistic technology to the preservation of Chinese medicinal materials. Summary of the Invention
[0004] To address the aforementioned problems, this application provides a method for preserving Chinese medicinal materials.
[0005] This application provides a method for preserving Chinese medicinal materials, the method comprising:
[0006] The Chinese medicinal materials were placed in a microwave-ultrasound composite field for microwave-ultrasound synergistic treatment, and then sealed for preservation.
[0007] The operating parameters of the microwave-ultrasound co-processing include: microwave power of 110-180W, ultrasonic power of 720-950W, and processing time of 20-40s.
[0008] Furthermore, the microwave power is 145–155W.
[0009] Furthermore, the ultrasonic power is 860-880W.
[0010] Furthermore, the processing time is 25–35 seconds.
[0011] Furthermore, the temperature of the microwave-ultrasound synergistic processing is 25–35°C.
[0012] Furthermore, the moisture content of the medicinal materials is 15-20 wt% by weight.
[0013] Furthermore, the storage method includes the following steps:
[0014] Fresh Chinese medicinal herbs are washed and then dried with hot air to obtain Chinese medicinal herbs with a preset moisture content.
[0015] The Chinese medicinal materials with the preset moisture content are placed in an ultrasonic-microwave combined reaction instrument for microwave-ultrasound synergistic treatment, and then sealed and stored.
[0016] Furthermore, the sealing and preservation method includes at least one of vacuum sealing and preservation by filling with inert gas.
[0017] Furthermore, the sealed storage environment temperature is 5–25°C.
[0018] Furthermore, the temperature of the hot air is 30–35°C.
[0019] The technical solutions provided in this application have at least the following advantages compared with the prior art:
[0020] This application provides a method for preserving Chinese medicinal materials. For the first time, this invention places Chinese medicinal materials in a microwave-ultrasound composite field under specific conditions. By utilizing the promoting synergistic effect between the physical fields, it was found that the stability of the effective components of Chinese medicinal materials can be significantly improved during preservation, and the preservation time can be extended, providing a new means for the preservation of Chinese medicinal materials. Detailed Implementation
[0021] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of this application will be clearly and completely described below in conjunction with the embodiments of this application. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.
[0022] Unless otherwise specified, all raw materials, reagents, instruments and equipment used in this application can be purchased from the market or prepared by existing methods.
[0023] This application provides a method for preserving Chinese medicinal materials, the method comprising:
[0024] The Chinese medicinal materials were placed in a microwave-ultrasound composite field for microwave-ultrasound synergistic treatment, and then sealed for preservation.
[0025] The operating parameters of the microwave-ultrasound co-processing include: microwave power of 110-180W, ultrasonic power of 720-950W, and processing time of 20-40s.
[0026] This application provides a method for preserving Chinese medicinal materials. For the first time, this invention places Chinese medicinal materials in a microwave-ultrasound composite field under specific conditions. By utilizing the promoting synergistic effect between the physical fields, it was found that the stability of the effective components of Chinese medicinal materials can be significantly improved during preservation, and the preservation time can be extended, providing a new means for the preservation of Chinese medicinal materials.
[0027] In some specific embodiments, the microwave power is 145–155 W. Preferably, the microwave power is 150 W.
[0028] In some specific embodiments, the ultrasonic power is 860-880W. Preferably, the ultrasonic power is 870W.
[0029] In some specific embodiments, the processing time is 25 to 35 seconds. Preferably, the processing time is 30 seconds.
[0030] In some specific embodiments, the temperature of the microwave-ultrasound synergistic processing is 25–35°C. Preferably, the temperature of the microwave-ultrasound synergistic processing is 30°C.
[0031] In some specific embodiments, the moisture content of the Chinese medicinal materials is 15-20 wt% by weight.
[0032] In some specific embodiments, the storage method includes the following steps:
[0033] Fresh Chinese medicinal herbs are washed and then dried with hot air to obtain Chinese medicinal herbs with a preset moisture content.
[0034] The Chinese medicinal materials with the preset moisture content are placed in an ultrasonic-microwave combined reaction instrument for microwave-ultrasound synergistic treatment, and then sealed and stored.
[0035] In this application, the "ultrasonic-microwave combined reaction instrument" refers to an instrument that can generate a microwave-ultrasonic composite field, such as the commercially available XO-SM series ultrasonic-microwave combined reaction system, ultrasonic-microwave reactor, and microwave-ultrasonic combined reaction instrument, etc.
[0036] In some specific embodiments, the sealing and preservation method includes at least one of vacuum sealing and preservation by filling with inert gas; specifically, it is placed in a sealed bag and then vacuum sealed.
[0037] In some specific embodiments, the ambient temperature for sealed storage is 5–25°C. Preferably, the ambient temperature for sealed storage is 10–15°C.
[0038] In some specific embodiments, the temperature of the hot air is 30–35°C.
[0039] It should be noted that, unless otherwise specified or explained, all components involved in the method for preserving Chinese medicinal materials provided in this application can be commercially available products; and unless otherwise specified or explained, all operational steps can be performed in accordance with the operating methods disclosed in the prior art or using existing equipment in accordance with its usage methods.
[0040] The present application is further illustrated below with reference to specific embodiments. It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the application. Experimental methods in the following embodiments that do not specify specific conditions are generally determined according to national standards. If there is no corresponding national standard, then general international standards, conventional conditions, or conditions recommended by the manufacturer are followed.
[0041] Example 1
[0042] This example provides a method for preserving Chinese medicinal materials. Taking fresh Rehmannia glutinosa as an example, the method for preserving Chinese medicinal materials includes the following steps:
[0043] Step (1): Clean the fresh Chinese medicinal materials harvested that year, and then dry them with hot air at a temperature of 34℃ to obtain Chinese medicinal materials with a moisture content of 18wt%.
[0044] Step (2): The Chinese medicinal materials with a moisture content of 18wt% obtained in step (1) are placed in an ultrasonic-microwave combined reaction instrument for microwave-ultrasound synergistic treatment, and then vacuum sealed and refrigerated at an ambient temperature of 10℃ for 12 months; wherein, the working parameters of the microwave-ultrasound synergistic treatment include: microwave power of 150W, ultrasonic power of 870W, and treatment time of 30s.
[0045] The content of effective components in Chinese medicinal materials before and after preservation was determined by chromatography (based on the content of catalpol in Rehmannia glutinosa). The retention rate of effective components η was calculated as (content of effective components in Chinese medicinal materials after 12 months of preservation / content of effective components in Chinese medicinal materials before preservation) × 100%. The test results in this example are shown in Table 1.
[0046] Example 2
[0047] This example provides a method for preserving Chinese medicinal materials. Taking fresh Rehmannia glutinosa as an example, the method for preserving Chinese medicinal materials includes the following steps:
[0048] Step (1): Clean the fresh Chinese medicinal materials harvested that year, and then dry them with hot air at a temperature of 34℃ to obtain Chinese medicinal materials with a moisture content of 15wt%.
[0049] Step (2): The Chinese medicinal materials with a moisture content of 15wt% obtained in step (1) are placed in an ultrasonic-microwave combined reaction instrument for microwave-ultrasound synergistic treatment, and then vacuum sealed and refrigerated at an ambient temperature of 10℃ for 12 months; wherein, the working parameters of the microwave-ultrasound synergistic treatment include: microwave power of 110W, ultrasonic power of 720W, and treatment time of 40s.
[0050] The content of effective components in Chinese medicinal materials before and after preservation was determined by chromatography (based on the content of catalpol in Rehmannia glutinosa). The retention rate of effective components η was calculated as (content of effective components in Chinese medicinal materials after 12 months of preservation / content of effective components in Chinese medicinal materials before preservation) × 100%. The test results in this example are shown in Table 1.
[0051] Example 3
[0052] This example provides a method for preserving Chinese medicinal materials. Taking fresh Rehmannia glutinosa as an example, the method for preserving Chinese medicinal materials includes the following steps:
[0053] Step (1): Clean the fresh Chinese medicinal materials harvested that year, and then dry them with hot air at a temperature of 34℃ to obtain Chinese medicinal materials with a moisture content of 20wt%.
[0054] Step (2): The Chinese medicinal materials with a moisture content of 20wt% obtained in step (1) are placed in an ultrasonic-microwave combined reaction instrument for microwave-ultrasound synergistic treatment, and then vacuum sealed and refrigerated at an ambient temperature of 10℃ for 12 months; wherein, the working parameters of the microwave-ultrasound synergistic treatment include: microwave power of 180W, ultrasonic power of 950W, and treatment time of 20s.
[0055] The content of effective components in Chinese medicinal materials before and after preservation was determined by chromatography (based on the content of catalpol in Rehmannia glutinosa). The retention rate of effective components η was calculated as (content of effective components in Chinese medicinal materials after 12 months of preservation / content of effective components in Chinese medicinal materials before preservation) × 100%. The test results in this example are shown in Table 1.
[0056] Comparative Example 1
[0057] This example provides a method for preserving Chinese medicinal materials. Taking fresh Rehmannia glutinosa as an example, the method for preserving Chinese medicinal materials includes the following steps:
[0058] Step (1): Clean the fresh Chinese medicinal materials harvested that year, and then dry them with hot air at a temperature of 34℃ to obtain Chinese medicinal materials with a moisture content of 18wt%.
[0059] Step (2): Place the Chinese medicinal materials with a moisture content of 18wt% obtained in step (1) into an ultrasonic device for ultrasonic treatment, then transfer them to a microwave instrument for microwave treatment, and finally vacuum seal and refrigerate them at an ambient temperature of 10℃ for 12 months; wherein, the working parameters of the ultrasonic treatment include: ultrasonic power of 870W and treatment time of 30s; the working parameters of the microwave treatment include: microwave power of 150W and treatment time of 30s.
[0060] The content of effective components in Chinese medicinal materials before and after preservation was determined by chromatography (based on the content of catalpol in Rehmannia glutinosa). The retention rate of effective components η was calculated as (content of effective components in Chinese medicinal materials after 12 months of preservation / content of effective components in Chinese medicinal materials before preservation) × 100%. The test results in this example are shown in Table 1.
[0061] Comparative Example 2
[0062] This example provides a method for preserving Chinese medicinal materials. Taking fresh Rehmannia glutinosa as an example, the method for preserving Chinese medicinal materials includes the following steps:
[0063] Step (1): Clean the fresh Chinese medicinal materials harvested that year, and then dry them with hot air at a temperature of 34℃ to obtain Chinese medicinal materials with a moisture content of 18wt%.
[0064] Step (2): The Chinese medicinal materials with a moisture content of 18wt% obtained in step (1) are placed in an ultrasonic-microwave combined reaction instrument for microwave-ultrasound synergistic treatment, and then vacuum sealed and refrigerated at an ambient temperature of 10℃ for 12 months; wherein, the working parameters of the microwave-ultrasound synergistic treatment include: microwave power of 50W, ultrasonic power of 870W, and treatment time of 30s.
[0065] The content of effective components in Chinese medicinal materials before and after preservation was determined by chromatography (based on the content of catalpol in Rehmannia glutinosa). The retention rate of effective components η was calculated as (content of effective components in Chinese medicinal materials after 12 months of preservation / content of effective components in Chinese medicinal materials before preservation) × 100%. The test results in this example are shown in Table 1.
[0066] Comparative Example 3
[0067] This example provides a method for preserving Chinese medicinal materials. Taking fresh Rehmannia glutinosa as an example, the method for preserving Chinese medicinal materials includes the following steps:
[0068] Step (1): Clean the fresh Chinese medicinal materials harvested that year, and then dry them with hot air at a temperature of 34℃ to obtain Chinese medicinal materials with a moisture content of 18wt%.
[0069] Step (2): The Chinese medicinal materials with a moisture content of 18wt% obtained in step (1) are placed in an ultrasonic-microwave combined reaction instrument for microwave-ultrasound synergistic treatment, and then vacuum sealed and refrigerated at an ambient temperature of 10℃ for 12 months; wherein, the working parameters of the microwave-ultrasound synergistic treatment include: microwave power of 500W, ultrasonic power of 870W, and treatment time of 30s.
[0070] The content of effective components in Chinese medicinal materials before and after preservation was determined by chromatography (based on the content of catalpol in Rehmannia glutinosa). The retention rate of effective components η was calculated as (content of effective components in Chinese medicinal materials after 12 months of preservation / content of effective components in Chinese medicinal materials before preservation) × 100%. The test results in this example are shown in Table 1.
[0071] Comparative Example 4
[0072] This example provides a method for preserving Chinese medicinal materials. Taking fresh Rehmannia glutinosa as an example, the method for preserving Chinese medicinal materials includes the following steps:
[0073] Step (1): Clean the fresh Chinese medicinal materials harvested that year, and then dry them with hot air at a temperature of 34℃ to obtain Chinese medicinal materials with a moisture content of 18wt%.
[0074] Step (2): The Chinese medicinal materials with a moisture content of 18wt% obtained in step (1) are placed in an ultrasonic-microwave combined reaction instrument for microwave-ultrasound synergistic treatment, and then vacuum sealed and refrigerated at an ambient temperature of 10℃ for 12 months; wherein, the working parameters of the microwave-ultrasound synergistic treatment include: microwave power of 150W, ultrasonic power of 200W, and treatment time of 30s.
[0075] The content of effective components in Chinese medicinal materials before and after preservation was determined by chromatography (based on the content of catalpol in Rehmannia glutinosa). The retention rate of effective components η was calculated as (content of effective components in Chinese medicinal materials after 12 months of preservation / content of effective components in Chinese medicinal materials before preservation) × 100%. The test results in this example are shown in Table 1.
[0076] Comparative Example 5
[0077] This example provides a method for preserving Chinese medicinal materials. Taking fresh Rehmannia glutinosa as an example, the method for preserving Chinese medicinal materials includes the following steps:
[0078] Step (1): Clean the fresh Chinese medicinal materials harvested that year, and then dry them with hot air at a temperature of 34℃ to obtain Chinese medicinal materials with a moisture content of 18wt%.
[0079] Step (2): The Chinese medicinal materials with a moisture content of 18wt% obtained in step (1) are placed in an ultrasonic-microwave combined reaction instrument for microwave-ultrasound synergistic treatment, and then vacuum sealed and refrigerated at an ambient temperature of 10℃ for 12 months; wherein, the working parameters of the microwave-ultrasound synergistic treatment include: microwave power of 150W, ultrasonic power of 870W, and treatment time of 2min.
[0080] The content of effective components in Chinese medicinal materials before and after preservation was determined by chromatography (based on the content of catalpol in Rehmannia glutinosa). The retention rate of effective components η was calculated as (content of effective components in Chinese medicinal materials after 12 months of preservation / content of effective components in Chinese medicinal materials before preservation) × 100%. The test results in this example are shown in Table 1.
[0081] Comparative Example 6
[0082] This example provides a method for preserving Chinese medicinal materials. Taking fresh Rehmannia glutinosa as an example, the method for preserving Chinese medicinal materials includes the following steps:
[0083] Step (1): Clean the fresh Chinese medicinal materials harvested that year, and then dry them with hot air at a temperature of 34℃ to obtain Chinese medicinal materials with a moisture content of 18wt%.
[0084] Step (2): The Chinese medicinal materials with a moisture content of 18wt% obtained in step (1) are vacuum sealed and refrigerated at an ambient temperature of 10℃ for 12 months.
[0085] The content of effective components in Chinese medicinal materials before and after preservation was determined by chromatography (based on the content of catalpol in Rehmannia glutinosa). The retention rate of effective components η was calculated as (content of effective components in Chinese medicinal materials after 12 months of preservation / content of effective components in Chinese medicinal materials before preservation) × 100%. The test results in this example are shown in Table 1.
[0086] Table 1
[0087]
[0088] As shown in Table 1, compared with the comparative example, the method for preserving Chinese medicinal materials provided in this application can significantly improve the stability of the effective components of Chinese medicinal materials during the preservation process and extend the preservation time, and Example 1 has the best effect.
[0089] In summary, the embodiments of this application provide a method for preserving Chinese medicinal materials. For the first time, this invention places Chinese medicinal materials in a microwave-ultrasound composite field under specific conditions. By utilizing the promoting synergistic effect between the physical fields, it was found that the stability of the effective components of Chinese medicinal materials can be significantly improved during the preservation process, and the preservation time can be extended, providing a new means for the preservation of Chinese medicinal materials.
[0090] Various embodiments of this application may exist in the form of a range; it should be understood that the description in the form of a range is merely for convenience and brevity and should not be construed as a hard limitation on the scope of this application; therefore, it should be considered that the range description has specifically disclosed all possible sub-ranges and single numerical values within that range. For example, it should be considered that the range description from 1 to 6 has specifically disclosed sub-ranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., and single numbers within the range, such as 1, 2, 3, 4, 5, and 6, regardless of the range. Furthermore, whenever a numerical range is referred to herein, it means including any referenced number (fraction or integer) within the referred range.
[0091] The above description is merely a specific embodiment of this application, enabling those skilled in the art to understand or implement this application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of this application. Therefore, this application is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features claimed herein.
Claims
1. A method for preserving traditional Chinese medicinal materials, characterized in that, The storage method includes: The Chinese medicinal materials were placed in a microwave-ultrasound composite field for microwave-ultrasound synergistic treatment, and then sealed for preservation. The operating parameters of the microwave-ultrasound co-processing include: microwave power of 110~180 W, ultrasonic power of 720~950 W, and processing time of 20~40 s. The moisture content of the medicinal materials is 15-20 wt% by weight. The medicinal herb mentioned is Rehmannia glutinosa.
2. The method for preserving Chinese medicinal materials according to claim 1, characterized in that, The microwave power is 145~155 W.
3. The method for preserving Chinese medicinal materials according to claim 1, characterized in that, The ultrasonic power is 860~880W.
4. The method for preserving Chinese medicinal materials according to claim 1, characterized in that, The processing time is 25-35 seconds.
5. The method for preserving Chinese medicinal materials according to claim 1, characterized in that, The temperature for the microwave-ultrasound synergistic processing is 25~35℃.
6. The method for preserving Chinese medicinal materials according to any one of claims 1 to 5, characterized in that, The storage method includes the following steps: Fresh Chinese medicinal herbs are washed and then dried with hot air to obtain Chinese medicinal herbs with a preset moisture content. The Chinese medicinal materials with the preset moisture content are placed in an ultrasonic-microwave combined reaction instrument for microwave-ultrasound synergistic treatment, and then sealed and stored.
7. The method for preserving Chinese medicinal materials according to claim 6, characterized in that, The sealing and preservation method includes at least one of vacuum sealing and preservation by filling with inert gas.
8. The method for preserving Chinese medicinal materials according to claim 6, characterized in that, The sealed storage environment temperature is 5~25℃.
9. The method for preserving Chinese medicinal materials according to claim 6, characterized in that, The temperature of the hot air is 30~35℃.