Use of porcine pepsin as catalyst in catalytic coupling reactions

Abstract

The application discloses application of porcine pepsin as a catalyst in catalyzing a coupling reaction, catalyzing a coupling reaction between t-butylamine (and derivatives thereof) and 4-chloro-1-butanol (and derivatives thereof), and synthesizing a secondary alcohol amine derivative in an organic solution at 25-35 DEG C. The porcine pepsin can be directly extracted from a digestive tract of a pig and belongs to a natural material and has a green biological catalyst. When the porcine pepsin is applied to catalyze a coupling reaction, a target product with a higher yield can be obtained, and a mild condition required by the catalytic reaction is worth popularizing and using. The application not only expands the application of the porcine pepsin in the field of catalyzing synthesis of organic small molecules, but also enriches the research on non-specificity of biological enzymes, and provides an efficient method for synthesizing a coupling reaction.

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