A self-adhesive eutectic gel electrode patch and a preparation method and application thereof

Abstract

The application discloses a self-adhesion eutectic gel electrode patch and a preparation method and application thereof, and belongs to the technical field of gel electrode materials. The self-adhesion eutectic gel electrode patch comprises the following raw materials: a carboxyl-containing monomer, polysaccharide, an initiator and a solvent; the amount of the polysaccharide is 1-10% of the mass of the carboxyl-containing monomer; and the amount of the initiator is 0.1-2.5% of the mass of the carboxyl-containing monomer. The eutectic gel electrode patch has excellent environmental stability, good conductive performance and mechanical performance in a wide temperature range of-40 DEG C to 60 DEG C, and the weight and shape of the eutectic gel remain almost unchanged under different humidity conditions. Moreover, the eutectic gel electrode patch prepared by the application has excellent adhesion, and can meet the requirements of long-time wearing and high-efficiency monitoring of patients.

Description

Technical Field

[0001] This invention relates to the field of gel electrode materials technology, and in particular to a self-adhesive eutectic gel electrode patch, its preparation method, and its application. Background Technology

[0002] Electrode patches are a type of medical auxiliary material used very frequently in hospitals. Medical diagnostics and treatments often involve attaching conductive electrodes that can transmit electrical signals to the patient's skin and connecting them to medical equipment to collect electrical signals from within the body. Therefore, electrode patches are required to have a certain degree of flexibility to ensure full contact with the skin. Common clinical applications include monitoring electroencephalogram (EEG) signals, cardiac activity (ECG scanning), transcutaneous electrical nerve stimulation (TENS), and neuromuscular electrical stimulation (EMS) techniques.

[0003] Electrode patches can be categorized by material, including PET self-adhesive electrode patches, silicone self-adhesive electrode patches, hydrogel self-adhesive electrode patches, and metal button self-adhesive electrode patches. However, these medical electrode patches encounter a series of problems in actual clinical use. For example, when long-term monitoring of patients is required, factors such as excessive hair growth, sweating, oil production, and the formation of new stratum corneum reduce the adhesion of the medical electrode patches. Simultaneously, the electrode patches themselves have poor environmental stability and are prone to deformation, leading to increased interfacial resistance between the electrode patch and the skin. This can generate misleading false current signals, reducing the accuracy and continuity of data acquisition, and ultimately affecting the reliability of the final monitoring results. Furthermore, due to their low mechanical and adhesive properties, most clinically used electrode patches are disposable. During long-term and repeated monitoring, new electrode patches need to be constantly replaced, increasing the financial burden on patients and causing resource waste and environmental pollution.

[0004] In response to the problems encountered in the use of the above-mentioned electrode patch materials, eutectic gels prepared from eutectic solvents have attracted attention. Eutectic gels have advantages such as high ionic conductivity, electrochemical stability, non-volatile nature, green and non-toxic properties, and low cost. However, the reported eutectic gels still cannot simultaneously possess good flexibility, high adhesion, high conductivity, and environmental stability, which limits their application in clinical medical electrode patches. Summary of the Invention

[0005] The purpose of this invention is to provide a self-adhesive eutectic gel electrode patch, its preparation method, and its application, so as to solve the problems existing in the prior art.

[0006] To achieve the above objectives, the present invention provides the following solution:

[0007] One of the technical solutions of the present invention is a self-adhesive eutectic gel electrode patch, the raw materials of which include: carboxyl-containing monomeric substances, polysaccharides, initiators and solvents;

[0008] The amount of the polysaccharide used is 1 to 10% of the mass of the carboxyl-containing monomeric substance;

[0009] The amount of the initiator is 0.1 to 2.5% of the mass of the carboxyl-containing monomer.

[0010] Preferably, the amount of the polysaccharide used is 1%, 2%, 3%, 4%, 5%, or 6% of the mass of the carboxyl-containing monomer.

[0011] Preferably, the amount of the initiator is 2% of the mass of the carboxyl-containing monomer.

[0012] Preferably, the carboxyl-containing monomer is a polymerizable monomer containing free carboxyl groups and carbon-carbon double bonds.

[0013] Preferably, the monomeric substance containing free carboxyl groups and carbon-carbon double bonds includes one or more of itaconic acid (IA), maleic acid, methacrylate-modified alginate (ALG-MA), methacrylate-modified hyaluronic acid (HA-MA), acrylate-modified alginate (ALG-AA), acrylate-modified hyaluronic acid (HA-AA), acrylic acid (AA), and methacrylic acid (MA); the solvent includes a eutectic solvent (DES).

[0014] The amount of the carboxyl-containing monomer is 5-50% of the mass of the eutectic solvent.

[0015] More preferably, the monomeric substance containing free carboxyl groups and carbon-carbon double bonds is acrylic acid (AA), methacrylic acid (MA), itaconic acid (IA), methacrylate-modified hyaluronic acid (HA-MA), methacrylate-modified alginic acid (ALG-MA), acrylate-modified alginic acid (ALG-AA), or acrylate-modified hyaluronic acid (HA-AA).

[0016] More preferably, the amount of the carboxyl-containing monomer is 5%, 10%, 15%, 20%, 25%, or 30% of the mass of the eutectic solvent.

[0017] Preferably, the eutectic solvent comprises hydrogen bond acceptors and hydrogen bond donors in a molar ratio of 1:1 to 1:6.

[0018] The hydrogen bond acceptors include one or more of choline chloride, betaine, cyclodextrin, sodium dodecanoate, and methyltrioctylammonium chloride;

[0019] More preferably, the hydrogen bond acceptor is choline chloride.

[0020] The hydrogen bond donors include one or more of glycerol, urea, ethylene glycol, malic acid, propylene glycol, thiourea, citric acid, xylitol, and amino acids;

[0021] More preferably, the hydrogen bond donor is glycerol or urea.

[0022] More preferably, the molar ratio of the hydrogen bond acceptor to the hydrogen bond donor is 1:2.

[0023] More preferably, the method for preparing the eutectic solvent includes the following steps: blending hydrogen bond acceptors and hydrogen bond donors in a molar ratio under heating conditions to obtain the eutectic solvent; the blending temperature is 60-100°C.

[0024] More preferably, the blending temperature is 90°C.

[0025] More preferably, when the hydrogen bond acceptor is choline chloride, the choline chloride needs to be pre-dried in a vacuum drying oven at a temperature of 60-90°C for 2-6 hours before being blended with the hydrogen bond donor.

[0026] More preferably, the drying temperature is 80°C and the time is 3 hours.

[0027] Preferably, the polysaccharide includes one or more of konjac glucomannan (KGM), starch, cellulose, xanthan gum, carrageenan, sodium alginate, and pectin.

[0028] More preferably, the polysaccharide is konjac glucomannan (KGM), starch, carrageenan, xanthan gum, or sodium alginate.

[0029] Preferably, the initiator includes any one of a photoinitiator, a thermal initiator, and a redox initiator;

[0030] The photoinitiator includes one or more of 2-hydroxy-4′-(2-hydroxyethoxy)-2-methylphenylacetone (2959), 2-hydroxy-2-methyl-1-phenylacetone (1173), 2,4,6-trimethylbenzoyl-diphenylphosphine oxide (TPO) and 1-hydroxycyclohexylphenyl ketone (184);

[0031] More preferably, the photoinitiator is 2-hydroxy-4′-(2-hydroxyethoxy)-2-methylphenylacetone (2959).

[0032] The thermal initiator includes one or more of ammonium persulfate (APS), potassium persulfate (KPS), benzoyl peroxide (BPO), and azobisisobutyronitrile (AIBN);

[0033] More preferably, the thermal initiator is potassium persulfate (KPS).

[0034] The redox initiator comprises two components: an oxidant and a reducing agent.

[0035] More preferably, the oxidant is ammonium persulfate (APS), and the reducing agent is a mixture of lignin and nano-silver or lignin.

[0036] Ammonium persulfate, potassium persulfate, and benzoyl peroxide belong to the peroxide class, while azobisisobutyronitrile belongs to the azo class. Peroxide initiators and azo initiators require higher decomposition temperatures (50-100℃) and are classified as thermal initiators.

[0037] Thermal initiators require higher temperatures to initiate polymerization, but redox initiation systems (or redox initiators) can initiate reactions at lower temperatures. They utilize free radicals generated by electron transfer between oxidants and reductants to initiate polymerization reactions. Therefore, redox initiators have the advantage of initiating polymerization reactions at lower temperatures compared to thermal initiators.

[0038] A redox initiation system consists of two components: an oxidant and a reductant. There are various types of redox initiation systems, one of which is the redox initiation system composed of persulfates (such as potassium, sodium, or ammonium salts). In this system, the persulfate (potassium, sodium, or ammonium salt) acts as the oxidant and cannot be considered a thermal initiator. Persulfates (potassium, sodium, or ammonium salts) have two initiation mechanisms: thermal decomposition initiation (which must be performed at a certain high temperature) and the participation of the oxidant in the reaction (which can occur at room temperature).

[0039] The second technical solution of the present invention: a method for preparing the above-mentioned self-adhesive eutectic gel electrode patch, comprising the following steps:

[0040] The carboxyl-containing monomer and polysaccharide were added to a eutectic solvent, stirred evenly under heating conditions, cooled, and then an initiator was added and mixed evenly to obtain a eutectic gel prepolymer solution.

[0041] After spreading the eutectic gel prepolymer liquid, a crosslinking reaction is carried out to obtain the self-adhesive eutectic gel electrode patch.

[0042] Preferably, when the initiator is a photoinitiator, the crosslinking reaction is carried out under light irradiation, with a wavelength of 250–420 nm and a duration of 5–15 min.

[0043] More preferably, when the initiator is a photoinitiator, the crosslinking reaction is carried out under light irradiation conditions, with a wavelength of 365 nm and a duration of 10 min.

[0044] When the initiator is a thermal initiator, the crosslinking reaction is carried out under heating conditions at a temperature of 60–80°C.

[0045] More preferably, when the initiator is a thermal initiator, the crosslinking reaction is carried out under heating conditions at a temperature of 60°C.

[0046] When the initiator is a redox initiator, the crosslinking reaction is carried out at room temperature, specifically at a temperature of 20–30°C.

[0047] More preferably, the stirring temperature under the heating conditions is 70–100°C.

[0048] More preferably, the stirring temperature under the heating conditions is 90°C.

[0049] The third technical solution of the present invention: the application of the above-mentioned self-adhesive eutectic gel electrode patch as a medical auxiliary material.

[0050] More preferably, the medical auxiliary materials include auxiliary materials for electrocardiogram monitoring devices, electroencephalogram monitoring devices, or electromyogram monitoring devices.

[0051] The present invention discloses the following technical effects:

[0052] (1) The eutectic gel electrode patch of the present invention has excellent environmental stability, exhibiting good electrical conductivity and mechanical properties over a wide temperature range of -40℃ to 60℃; simultaneously, the weight and shape of the eutectic gel remain almost unchanged under different humidity conditions. Therefore, the eutectic gel electrode patch prepared by the present invention can meet the requirements of patients for long-term wear and efficient monitoring.

[0053] (2) The eutectic gel electrode patch of the present invention is non-cytotoxic, does not cause allergic reactions when in contact with human skin for a long time, can be cut into any shape, is easy to use, and has a low interfacial impedance with human skin, so there is no need to clean the human skin before use.

[0054] (3) The present invention forms a dynamic dense network by physically crosslinking the carboxyl groups of acrylic acid with polysaccharides and hydroxyl groups in a eutectic solvent. The resulting eutectic gel has good softness, adhesion, high conductivity and environmental stability.

[0055] (4) The eutectic gel electrode patch prepared by the present invention has excellent adhesion properties. It can not only adhere to various metal and plastic products, but also has high adhesion to human skin, pig skin and pig intestines. Furthermore, this eutectic gel electrode patch can be reused multiple times. At the same time, when the skin sweats or produces oil, the adhesion strength decreases slightly after repeated use. Therefore, the eutectic gel electrode patch prepared by the present invention can effectively avoid the phenomenon of slippage, misalignment or even detachment during the monitoring process. Attached Figure Description

[0056] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0057] Figure 1 This is an image showing the adhesion of the eutectic gel 13 prepared in Example 13 of the present invention to human skin;

[0058] Figure 2 Images of the eutectic gel 13 prepared in Example 13 of this invention before and after exercise after being applied to the skin;

[0059] Figure 3 The adhesion values ​​of the eutectic gel 13 prepared in Example 13 of this invention on different substrates;

[0060] Figure 4 The porcine skin adhesion value of the eutectic gel 13 prepared in Example 13 of the present invention under different environmental conditions;

[0061] Figure 5 The adhesion value of the eutectic gel 13 prepared in Example 13 of this invention after 5 cycles of bonding to pigskin;

[0062] Figure 6 The results of the cytotoxicity test of the cocrystal gel 13 prepared in Example 13 of this invention;

[0063] Figure 7 The weight change test results of the eutectic gel 13 prepared in Example 13 of the present invention under different humidity conditions at room temperature;

[0064] Figure 8 The results of interfacial impedance tests between the eutectic gel 13 prepared in Example 13 of this invention and the skin at different frequencies are shown.

[0065] Figure 9 The electromyography results are for the eutectic gel 13 prepared in Example 13 of this invention.

[0066] Figure 10 The electrocardiogram test results are for the eutectic gel 13 prepared in Example 13 of this invention;

[0067] Figure 11 The results of electrooculography (EOG) testing of the eutectic gel 13 prepared in Example 13 of this invention;

[0068] Figure 12 The electroencephalogram (EEG) test results are for the eutectic gel 13 prepared in Example 13 of this invention. Detailed Implementation

[0069] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as a limitation of the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0070] It should be understood that the terminology used in this invention is merely for describing particular embodiments and is not intended to limit the invention. Furthermore, with respect to numerical ranges in this invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Every smaller range between any stated value or intermediate value within a stated range, and any other stated value or intermediate value within said range, is also included in this invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0071] Unless otherwise stated, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. While only preferred methods and materials have been described herein, any methods and materials similar or equivalent to those described herein may be used in the implementation or testing of this invention. All references to this specification are incorporated by way of citation to disclose and describe methods and / or materials associated with those references. In the event of any conflict with any incorporated reference, the content of this specification shall prevail.

[0072] Various modifications and variations can be made to the specific embodiments described in this specification without departing from the scope or spirit of the invention, as will be apparent to those skilled in the art. Other embodiments derived from this specification will also be obvious to those skilled in the art. This application specification and embodiments are merely exemplary.

[0073] The terms “include,” “including,” “have,” “contain,” etc., used in this article are all open-ended terms, meaning that they include but are not limited to.

[0074] In a first aspect, the present invention provides a self-adhesive eutectic gel electrode patch, the raw materials of which include: a carboxyl-containing monomer, a polysaccharide, an initiator, and a solvent;

[0075] In this invention, the amount of polysaccharide used is 1 to 10% of the mass of the carboxyl-containing monomer; the amount of initiator used is 0.1 to 2.5% of the mass of the carboxyl-containing monomer.

[0076] Preferably, the amount of polysaccharide used is 1%, 2%, 3%, 4%, 5%, or 6% of the mass of the carboxyl-containing monomer. The amount of initiator used is 2% of the mass of the carboxyl-containing monomer.

[0077] In this invention, the monomeric material containing a carboxyl group is a polymerizable monomeric material containing a free carboxyl group and a carbon-carbon double bond.

[0078] Preferably, the monomeric substances containing free carboxyl groups and carbon-carbon double bonds include one or more of itaconic acid (IA), maleic acid, methacrylate-modified alginic acid (ALG-MA), methacrylate-modified hyaluronic acid (HA-MA), acrylate-modified alginic acid (ALG-AA), acrylate-modified hyaluronic acid (HA-AA), acrylic acid (AA), and methacrylic acid (MA); the solvent includes a eutectic solvent (DES); and the amount of the carboxyl-containing monomeric substance is 5-50% of the mass of the eutectic solvent.

[0079] More preferably, the monomeric substances containing free carboxyl groups and carbon-carbon double bonds are acrylic acid (AA), methacrylic acid (MA), itaconic acid (IA), methacrylate-modified alginic acid (ALG-MA), methacrylate-modified hyaluronic acid (HA-MA), acrylate-modified alginic acid (ALG-AA), or acrylate-modified hyaluronic acid (HA-AA).

[0080] The monomeric material containing carboxyl groups used in this invention has free carboxyl groups and carbon-carbon double bonds. The free carboxyl groups can make the monomer weakly acidic, which is a common property of acids. The carbon-carbon double bonds can undergo addition and polymerization reactions.

[0081] More preferably, the amount of the carboxyl-containing monomer is 5%, 10%, 15%, 20%, 25% or 30% of the mass of the eutectic solvent.

[0082] The eutectic solvent in this invention comprises hydrogen bond acceptors and hydrogen bond donors in a molar ratio of 1:1 to 1:6.

[0083] Hydrogen bond acceptors include one or more of choline chloride, betaine, cyclodextrin, sodium dodecanoate, and methyltrioctylammonium chloride;

[0084] Preferably, the hydrogen bond acceptor is choline chloride.

[0085] Hydrogen bond donors include one or more of glycerol, urea, ethylene glycol, malic acid, propylene glycol, thiourea, citric acid, xylitol, and amino acids;

[0086] Preferably, the hydrogen bond donor is glycerol or urea.

[0087] Preferably, the molar ratio of hydrogen bond acceptor to hydrogen bond donor is 1:2.

[0088] The method for preparing the eutectic solvent in this invention includes the following steps: blending hydrogen bond acceptors and hydrogen bond donors in a molar ratio under heating conditions to obtain the eutectic solvent; the blending temperature is 60-100℃.

[0089] Preferably, the blending temperature is 90°C.

[0090] Preferably, when the hydrogen bond acceptor is choline chloride, the choline chloride needs to be pre-dried in a vacuum drying oven at a temperature of 60-90°C for 2-6 hours before being blended with the hydrogen bond donor.

[0091] More preferably, the drying temperature is 80°C and the time is 3 hours.

[0092] The polysaccharides in this invention include one or more of konjac glucomannan (KGM), starch, cellulose, xanthan gum, carrageenan, sodium alginate, and pectin.

[0093] The polysaccharide used in this invention is characterized by its large molecular weight, high aqueous solution viscosity, good stability, numerous polar functional groups, and good biocompatibility, which enhances the network forces and improves the mechanical properties of the final gel.

[0094] Preferably, the polysaccharide is konjac glucomannan (KGM), starch, carrageenan, xanthan gum, or sodium alginate.

[0095] The initiator in this invention includes one or more of photoinitiators, thermal initiators, and redox initiators;

[0096] Photoinitiators include one or more of 2-hydroxy-4′-(2-hydroxyethoxy)-2-methylphenylacetone (2959), 2-hydroxy-2-methyl-1-phenylacetone (1173), 2,4,6-trimethylbenzoyl-diphenylphosphine oxide (TPO) and 1-hydroxycyclohexylphenyl ketone (184);

[0097] Preferably, the photoinitiator is 2-hydroxy-4′-(2-hydroxyethoxy)-2-methylphenylacetone (2959).

[0098] Thermal initiators include one or more of ammonium persulfate (APS), potassium persulfate (KPS), benzoyl peroxide (BPO), and azobisisobutyronitrile (AIBN);

[0099] Preferably, the thermal initiator is potassium persulfate (KPS).

[0100] Redox initiators consist of two components: an oxidant and a reducing agent.

[0101] Preferably, the oxidant is ammonium persulfate (APS), and the reducing agent is a mixture of lignin and nano-silver or lignin.

[0102] A second aspect of the present invention provides a method for preparing a self-adhesive eutectic gel electrode patch, comprising the following steps:

[0103] The carboxyl-containing monomer and polysaccharide were added to a eutectic solvent, stirred evenly under heating conditions, cooled, and then an initiator was added and mixed evenly to obtain a eutectic gel prepolymer solution.

[0104] After spreading the eutectic gel prepolymer, a cross-linking reaction is carried out to obtain a self-adhesive eutectic gel electrode patch.

[0105] In this invention, when the initiator is a photoinitiator, the crosslinking reaction is carried out under light irradiation conditions, with a wavelength of 250–420 nm and a duration of 5–15 min.

[0106] Preferably, when the initiator is a photoinitiator, the crosslinking reaction is carried out under light irradiation conditions, with a wavelength of 365 nm and a duration of 10 min.

[0107] In this invention, when the initiator is a thermal initiator, the crosslinking reaction is carried out under heating conditions, and the heating temperature is 60-80°C;

[0108] Preferably, when the initiator is a thermal initiator, the crosslinking reaction is carried out under heating conditions, and the heating temperature is 60°C.

[0109] In this invention, when the initiator is a redox initiator, the crosslinking reaction is carried out at room temperature, which is 30°C.

[0110] Preferably, the stirring temperature under heating conditions is 70–100°C.

[0111] More preferably, the stirring temperature under heating conditions is 90°C.

[0112] The self-adhesive eutectic gel electrode patch prepared using the above-mentioned raw materials and preparation methods of the present invention has advantages such as high adhesion, good environmental stability, conductivity, and no cytotoxicity, and can be used as a medical auxiliary material.

[0113] A third aspect of the present invention provides an application of a self-adhesive eutectic gel electrode patch as a medical auxiliary material.

[0114] The medical auxiliary materials in this invention include auxiliary materials for electrocardiogram monitoring devices, electroencephalogram monitoring devices, or electromyogram monitoring devices.

[0115] The following embodiments of the present invention utilize the preparation method of the eutectic solvent 1:

[0116] Choline chloride was dried in a vacuum oven at 80°C for 3 hours beforehand. Then, the dried choline chloride and glycerol were heated and stirred at 90°C in a molar ratio of 1:2 until transparent to obtain eutectic solvent 1.

[0117] The following embodiments of the present invention utilize the preparation method of the eutectic solvent 2:

[0118] Choline chloride was pre-dried in a vacuum oven at 80°C for 3 hours. Then, the dried choline chloride and urea were heated and stirred at 90°C in a molar ratio of 1:2 until transparent to obtain eutectic solvent 2.

[0119] Example 1

[0120] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 1):

[0121] Acrylic acid (5% of the mass of eutectic solvent 1) and konjac glucomannan (KGM, 1% of the mass of acrylic acid) were added to eutectic solvent 1 (DES). The mixture was heated and stirred at 90°C until homogeneous, then cooled to room temperature. Photoinitiator 2959 (2-hydroxy-4′-(2-hydroxyethoxy)-2-methylphenylacetone, 2% of the mass of acrylic acid) was added, and the mixture was stirred for 5 minutes in the dark to obtain a eutectic gel prepolymer. The eutectic gel prepolymer was poured into a polytetrafluoroethylene mold, covered with a glass slide, and irradiated with a UV curing lamp with a wavelength of 365 nm for 10 minutes (crosslinking reaction) to obtain eutectic gel 1.

[0122] Example 2

[0123] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 2):

[0124] Acrylic acid (10% of the mass of eutectic solvent 1) and konjac glucomannan (KGM, 1% of the mass of acrylic acid) were added to eutectic solvent 1 (DES). The mixture was heated and stirred at 90°C until homogeneous, then cooled to room temperature. Photoinitiator 2959 (2-hydroxy-4′-(2-hydroxyethoxy)-2-methylphenylacetone, 2% of the mass of acrylic acid) was added, and the mixture was stirred for 5 minutes in the dark to obtain a eutectic gel prepolymer. The eutectic gel prepolymer was poured into a polytetrafluoroethylene mold, covered with a glass slide, and irradiated with a UV curing lamp with a wavelength of 365 nm for 10 minutes (crosslinking reaction) to obtain eutectic gel 2.

[0125] Example 3

[0126] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 3):

[0127] Acrylic acid (15% of the mass of eutectic solvent 1) and konjac glucomannan (KGM, 1% of the mass of acrylic acid) were added to eutectic solvent 1 (DES). The mixture was heated and stirred at 90°C until homogeneous, then cooled to room temperature. Photoinitiator 2959 (2-hydroxy-4′-(2-hydroxyethoxy)-2-methylphenylacetone, 2% of the mass of acrylic acid) was added, and the mixture was stirred for 5 minutes in the dark to obtain a eutectic gel prepolymer. The eutectic gel prepolymer was poured into a polytetrafluoroethylene mold, covered with a glass slide, and irradiated with a UV curing lamp with a wavelength of 365 nm for 10 minutes (crosslinking reaction) to obtain eutectic gel 3.

[0128] Example 4

[0129] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 4):

[0130] Acrylic acid (20% of the mass of eutectic solvent 1) and konjac glucomannan (KGM, 1% of the mass of acrylic acid) were added to eutectic solvent 1 (DES). The mixture was heated and stirred at 90°C until homogeneous, then cooled to room temperature. Photoinitiator 2959 (2-hydroxy-4′-(2-hydroxyethoxy)-2-methylphenylacetone, 2% of the mass of acrylic acid) was added, and the mixture was stirred for 5 minutes in the dark to obtain a eutectic gel prepolymer. The eutectic gel prepolymer was poured into a polytetrafluoroethylene mold, covered with a glass slide, and irradiated with a UV curing lamp with a wavelength of 365 nm for 10 minutes (crosslinking reaction) to obtain eutectic gel 4.

[0131] Example 5

[0132] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 5):

[0133] Acrylic acid (25% of the mass of eutectic solvent 1) and konjac glucomannan (KGM, 1% of the mass of acrylic acid) were added to eutectic solvent 1 (DES). The mixture was heated and stirred at 90°C until homogeneous, then cooled to room temperature. Photoinitiator 2959 (2-hydroxy-4′-(2-hydroxyethoxy)-2-methylphenylacetone, 2% of the mass of acrylic acid) was added, and the mixture was stirred for 5 minutes in the dark to obtain a eutectic gel prepolymer. The eutectic gel prepolymer was poured into a polytetrafluoroethylene mold, covered with a glass slide, and irradiated with a UV curing lamp with a wavelength of 365 nm for 10 minutes (crosslinking reaction) to obtain eutectic gel 5.

[0134] Example 6

[0135] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 6):

[0136] Acrylic acid (30% of the mass of eutectic solvent 1) and konjac glucomannan (KGM, 1% of the mass of acrylic acid) were added to eutectic solvent 1 (DES). The mixture was heated and stirred at 90°C until homogeneous, then cooled to room temperature. Photoinitiator 2959 (2-hydroxy-4′-(2-hydroxyethoxy)-2-methylphenylacetone, 2% of the mass of acrylic acid) was added, and the mixture was stirred for 5 minutes in the dark to obtain a eutectic gel prepolymer. The eutectic gel prepolymer was poured into a polytetrafluoroethylene mold, covered with a glass slide, and irradiated with a UV curing lamp with a wavelength of 365 nm for 10 minutes (crosslinking reaction) to obtain eutectic gel 6.

[0137] Example 7

[0138] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 7):

[0139] Methacrylic acid (30% of the mass of eutectic solvent 1) and konjac glucomannan (KGM, 1% of the mass of methacrylic acid) were added to eutectic solvent 1 (DES). The mixture was heated and stirred at 90°C until homogeneous, then cooled to room temperature. Photoinitiator 2959 (2-hydroxy-4′-(2-hydroxyethoxy)-2-methylphenylacetone, 2% of the mass of methacrylic acid) was added, and the mixture was stirred for 5 minutes in the dark to obtain a eutectic gel prepolymer. The eutectic gel prepolymer was poured into a polytetrafluoroethylene mold, covered with a glass slide, and irradiated with a UV curing lamp with a wavelength of 365 nm for 10 minutes (crosslinking reaction) to obtain eutectic gel 7.

[0140] Example 8

[0141] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 8):

[0142] Acrylic acid (30% of the mass of eutectic solvent 1) and konjac glucomannan (KGM, 1% of the mass of acrylic acid) were added to eutectic solvent 1 (DES), heated and stirred at 90°C until homogeneous, then cooled to room temperature. Potassium persulfate (KPS, 2% of the mass of acrylic acid) was added as a thermal initiator, and stirring was continued for 10 min to obtain a eutectic gel prepolymer. The eutectic gel prepolymer was poured into a polytetrafluoroethylene mold, covered with a glass slide, and then placed in a 60°C oven for crosslinking reaction for 2 h to obtain eutectic gel 8.

[0143] Example 9

[0144] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 9):

[0145] (1) Add acrylic acid (30% of the mass of eutectic solvent 1) and konjac glucomannan (KGM, 1% of the mass of acrylic acid) to eutectic solvent 1 (DES), heat and stir at 90°C until homogeneous, and then cool to room temperature to obtain solution A.

[0146] (2) Add 0.05g of sodium lignosulfonate to 4g of eutectic solvent 1 and stir at room temperature until the powder is completely dissolved. Then add 0.03g of nano silver and stir at room temperature for 1h to obtain solution B.

[0147] (3) Add 20g of solution A and ammonium persulfate (APS, the amount of which is 2% of the mass of acrylic acid in solution A) to solution B, mix and stir at room temperature for 4min to obtain eutectic gel prepolymer solution, pour the eutectic gel prepolymer solution into a silicone mold, let it stand at room temperature for 30min (crosslinking reaction) to obtain eutectic gel 9.

[0148] Example 10

[0149] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 10):

[0150] (1) Add acrylic acid (30% of the mass of eutectic solvent 1) and starch (1% of the mass of acrylic acid) to eutectic solvent 1 (DES), heat and stir at 90°C until homogeneous, and then cool to room temperature to obtain solution A.

[0151] (2) Add 0.05g of sodium lignosulfonate to 4g of eutectic solvent 1 and stir at room temperature until the powder is completely dissolved. Then add 0.03g of nano silver and stir at room temperature for 1h to obtain solution B.

[0152] (3) Add 20g of solution A and ammonium persulfate (APS, the amount of which is 2% of the mass of acrylic acid in solution A) to solution B, mix and stir at room temperature for 4min to obtain eutectic gel prepolymer solution, pour the eutectic gel prepolymer solution into a silicone mold, and let it stand at room temperature for 30min (crosslinking reaction) to obtain eutectic gel 10.

[0153] Example 11

[0154] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 11):

[0155] (1) Add acrylic acid (30% of the mass of eutectic solvent 1) and carrageenan (1% of the mass of acrylic acid) to eutectic solvent 1 (DES), heat and stir at 90°C until homogeneous, and then cool to room temperature to obtain solution A.

[0156] (2) Add 0.05g of sodium lignosulfonate to 4g of eutectic solvent 1 and stir at room temperature until the powder is completely dissolved. Then add 0.03g of nano silver and stir at room temperature for 1h to obtain solution B.

[0157] (3) Add 20g of solution A and ammonium persulfate (APS, the amount of which is 2% of the mass of acrylic acid in solution A) to solution B, mix and stir at room temperature for 4min to obtain eutectic gel prepolymer, pour the eutectic gel prepolymer into a silicone mold, and let it stand at room temperature for 30min (crosslinking reaction) to obtain eutectic gel 11.

[0158] Example 12

[0159] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 12):

[0160] (1) Add acrylic acid (30% of the mass of eutectic solvent 1) and konjac glucomannan (KGM, 2% of the mass of acrylic acid) to eutectic solvent 1 (DES), heat and stir at 90°C until homogeneous, and then cool to room temperature to obtain solution A.

[0161] (2) Add 0.05g of sodium lignosulfonate to 4g of eutectic solvent 1 and stir at room temperature until the powder is completely dissolved. Then add 0.03g of nano silver and stir at room temperature for 1h to obtain solution B.

[0162] (3) Add 20g of solution A and ammonium persulfate (APS, the amount of which is 2% of the mass of acrylic acid in solution A) to solution B, mix and stir at room temperature for 4min to obtain eutectic gel prepolymer solution, pour the eutectic gel prepolymer solution into a silicone mold, let it stand at room temperature for 30min (crosslinking reaction) to obtain eutectic gel 12.

[0163] Example 13

[0164] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 13):

[0165] (1) Add acrylic acid (30% of the mass of eutectic solvent 1) and konjac glucomannan (KGM, 3% of the mass of acrylic acid) to eutectic solvent 1 (DES), heat and stir at 90°C until homogeneous, and then cool to room temperature to obtain solution A.

[0166] (2) Add 0.05g of sodium lignosulfonate to 4g of eutectic solvent 1 and stir at room temperature until the powder is completely dissolved. Then add 0.03g of nano silver and stir at room temperature for 1h to obtain solution B.

[0167] (3) Add 20g of solution A and ammonium persulfate (APS, the amount of which is 2% of the mass of acrylic acid in solution A) to solution B, mix and stir at room temperature for 4min to obtain eutectic gel prepolymer, pour the eutectic gel prepolymer into a silicone mold, and let it stand at room temperature for 30min (crosslinking reaction) to obtain eutectic gel 13.

[0168] Example 14

[0169] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 14):

[0170] (1) Add acrylic acid (30% of the mass of eutectic solvent 1) and konjac glucomannan (KGM, 4% of the mass of acrylic acid) to eutectic solvent 1 (DES), heat and stir at 90°C until homogeneous, and then cool to room temperature to obtain solution A.

[0171] (2) Add 0.05g of sodium lignosulfonate to 4g of eutectic solvent 1 and stir at room temperature until the powder is completely dissolved. Then add 0.03g of nano silver and stir at room temperature for 1h to obtain solution B.

[0172] (3) Add 20g of solution A and ammonium persulfate (APS, the amount of which is 2% of the mass of acrylic acid in solution A) to solution B, mix and stir at room temperature for 4min to obtain eutectic gel prepolymer solution, pour the eutectic gel prepolymer solution into a silicone mold, and let it stand at room temperature for 30min (crosslinking reaction) to obtain eutectic gel 14.

[0173] Example 15

[0174] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 15):

[0175] (1) Add acrylic acid (30% of the mass of eutectic solvent 1) and konjac glucomannan (KGM, 5% of the mass of acrylic acid) to eutectic solvent 1 (DES), heat and stir at 90°C until homogeneous, and then cool to room temperature to obtain solution A.

[0176] (2) Add 0.05g of sodium lignosulfonate to 4g of eutectic solvent 1 and stir at room temperature until the powder is completely dissolved. Then add 0.03g of nano silver and stir at room temperature for 1h to obtain solution B.

[0177] (3) Add 20g of solution A and ammonium persulfate (APS, the amount of which is 2% of the mass of acrylic acid in solution A) to solution B, mix and stir at room temperature for 4min to obtain eutectic gel prepolymer solution, pour the eutectic gel prepolymer solution into a silicone mold, let it stand at room temperature for 30min (crosslinking reaction) to obtain eutectic gel 15.

[0178] Example 16

[0179] A method for preparing a self-adhesive eutectic gel electrode patch (eutectic gel 16):

[0180] (1) Add acrylic acid (30% of the mass of eutectic solvent 1) and konjac glucomannan (KGM, 6% of the mass of acrylic acid) to eutectic solvent 1 (DES), heat and stir at 90°C until homogeneous, and then cool to room temperature to obtain solution A.

[0181] (2) Add 0.05g of sodium lignosulfonate to 4g of eutectic solvent 1 and stir at room temperature until the powder is completely dissolved. Then add 0.03g of nano silver and stir at room temperature for 1h to obtain solution B.

[0182] (3) Add 20g of solution A and ammonium persulfate (APS, the amount of which is 2% of the mass of acrylic acid in solution A) to solution B, mix and stir at room temperature for 4min to obtain eutectic gel prepolymer. Pour the eutectic gel prepolymer into a silicone mold and let it stand at room temperature for 30min (crosslinking reaction) to obtain eutectic gel 16.

[0183] Examples 17-21

[0184] Same as Example 6, except that acrylic acid is replaced with equal amounts of itaconic acid, methacrylate-modified alginic acid, methacrylate-modified hyaluronic acid, acrylate-modified alginic acid, or acrylate-modified hyaluronic acid.

[0185] Examples 22-23

[0186] Same as Example 9, except that konjac glucomannan is replaced with an equal amount of xanthan gum or sodium alginate.

[0187] Example 24

[0188] Same as Example 9, except that 0.05g of sodium lignosulfonate and 0.03g of nano silver are replaced with 0.05g of sodium lignosulfonate.

[0189] Example of effect 1

[0190] The adhesion images of the eutectic gel 13 prepared in Example 13 of this invention on human skin are shown below. Figure 1 The images of the eutectic gel 13 prepared in Example 13 of this invention before and after 4 hours of continuous exercise (climbing stairs, running, playing badminton) after being applied to the skin are shown below. Figure 2 .

[0191] from Figure 1 and Figure 2 As can be seen from the above, the eutectic gel 13 prepared in Example 13 of the present invention has excellent adhesion properties on human skin.

[0192] Example 2

[0193] The adhesion values ​​of the self-adhesive eutectic gel electrode patch (eutectic gel 13) prepared in Example 13 of this invention were measured on different substrates, and the results are shown in the figure. Figure 3 .

[0194] Figure 3 In the Chinese text, "Porcine skin" refers to pigskin; "Rubber" refers to rubber; "Glass" refers to glass; and "Cu" refers to copper sheet.

[0195] The determination method is as follows:

[0196] The adhesion test was conducted using an lap shear test method and a universal testing machine (model 2kN, CMT1203). The eutectic gel was cut into rectangles 10mm long, 10mm wide, and 2mm thick. The cut eutectic gel was then applied between two substrates and pressed for 1 minute. The substrate with the eutectic gel was then attached to a fixture. The loading rate was kept constant at 200mm / min at room temperature to obtain the adhesion values.

[0197] from Figure 3 As can be seen, the eutectic gel has good adhesion properties on pigskin, rubber, glass and copper sheets, and its properties meet one of the conditions for use as a medical auxiliary material.

[0198] Example 3

[0199] The adhesion value of the self-adhesive eutectic gel electrode patch (eutectic gel 13) prepared in Example 13 of this invention to pigskin under different environmental conditions was measured, and the results are shown in the figure. Figure 4 .

[0200] Figure 4 In the table, Oil represents oil, Water represents water, Sweat represents artificial sweat, and Normal represents the control group.

[0201] The determination method is as follows:

[0202] The adhesion test was conducted using an overlap shear test method and a universal testing machine (model 2kN, CMT1203). The eutectic gel was cut into rectangular pieces 10mm long, 10mm wide, and 2mm thick. The cut eutectic gel was then applied to a piece of pigskin 5cm long and 2cm wide. 1μL of a different liquid (oil, water, or artificial sweat) was coated onto the surface of another piece of pigskin 5cm long and 2cm wide, covering an area of ​​2cm × 2cm. The liquid-coated area was then attached to the other side of the eutectic gel. After pressing for 1 minute, the pigskin with the eutectic gel attached was attached to a fixture. The loading rate was kept constant at 200mm / min at room temperature to obtain the adhesion values.

[0203] from Figure 4 As can be seen, compared to the adhesion value of the control group, the eutectic gel maintains high adhesion even in the presence of sweat, and the adhesion value decreases less in the presence of water and oil. This indicates that the eutectic gel exhibits good adhesion under different conditions, and as an electrode patch, it can cope with situations where it is prone to detachment due to sweat, water, and oil.

[0204] Example of effect 4

[0205] The adhesion value of the self-adhesive eutectic gel electrode patch (eutectic gel 13) prepared in Example 13 of this invention was measured after 5 cycles of cyclic bonding to pigskin. The results are shown in the figure. Figure 5 .

[0206] The testing method was as follows: An lap shear test was conducted using a universal mechanical testing machine (model 2kN, CMT1203). The eutectic gel was cut into rectangular pieces 10mm long, 10mm wide, and 2mm thick. The cut eutectic gel was then applied between two pieces of pigskin, pressed for 1 minute, and then the pigskin with the eutectic gel attached was attached to a fixture for testing. After each adhesion test, the pigskin that had peeled off the eutectic gel was replaced with a new piece, and this cycle was repeated 5 times. The loading rate was kept constant at 200mm / min at room temperature to obtain the adhesion values.

[0207] from Figure 5 As can be seen, the eutectic gel exhibits good adhesion in five cycles of overlap shear test on pigskin, indicating that the eutectic gel can be used and bonded multiple times on human skin.

[0208] Example 5

[0209] The cytotoxicity, weight change under different humidity levels (at room temperature), and interfacial impedance properties with skin at different frequencies of the eutectic gel 13 prepared in Example 13 of this invention were determined. The results are shown in [Figure Number]. Figures 6-8 .

[0210] The cytotoxicity assay was performed using the CCK8 assay to detect the cytotoxicity of the cocrystal gel to cells. First, 0.2 g of cocrystal gel 13 was soaked in 10 mL of complete culture medium overnight to obtain a 20 g / L gel extract stock solution. This stock solution was then diluted to obtain a 0.2 g / L gel extract. Next, 100 μL of fibroblast solution was seeded into 96-well plates (each well containing 5 × 10⁶ cells). 3Cells were cultured in an incubator for 24 hours, then the culture medium in the 96-well plate was aspirated, and an equal volume of 0.2 g / L gel extraction buffer was added. After culturing for 1, 3, and 5 days, 10 μL of CCK8 was added to each well, and the plates were incubated at 37°C for another 2 hours. The absorbance of the samples was measured at 460 nm using a microplate reader. Cell viability was determined by the ratio of the absorbance of different samples (sample, co-crystal gel sample group prepared with gel extraction buffer) to the absorbance of the control sample (control, sample group prepared with complete culture medium). The results are shown in [Figure Number]. Figure 6 .

[0211] The method for testing the interfacial impedance with skin at different frequencies is as follows: Electrochemical impedance spectroscopy (EIS) was obtained using an electrochemical workstation. First, the eutectic gel was cut into rectangular pieces, 2.5 cm long, 1.5 cm wide, and 1 mm thick. Then, the cut eutectic gel was applied to the arm, and the 1 Hz-10 Hz interfacial impedance was measured using a two-electrode method with the electrochemical workstation. 4 The interface impedance values ​​between Hz are shown in the results. Figure 8 .

[0212] from Figure 6 As can be seen, the cell viability of the co-crystal gel sample groups obtained after different culture days all reached 99.9% or higher, indicating that the prepared co-crystal gel was non-cytotoxic.

[0213] from Figure 7 As can be seen, under low humidity conditions of 50% ± 5% at room temperature, the maximum weight gain of the eutectic gel within 100 hours is only 5% of its original weight. Under high humidity conditions of 70% ± 5% at room temperature, the maximum weight gain of the gel within 100 hours is approximately 15% of its original weight. Based on the above data, it can be concluded that the prepared eutectic gel electrode patch has good environmental stability and can be used for a long time at room temperature.

[0214] from Figure 8 As can be seen, the measured interfacial impedance values ​​range from 1 Hz to 10 Hz. 4 The impedance gradually decreases within the Hz range, and at 1Hz, the impedance value is less than 10kΩ, indicating that the interfacial impedance between the eutectic gel and the skin is small. A smaller impedance value allows for more accurate recording of electrical signals.

[0215] Example 6

[0216] The electromyography (EMG) of the self-adhesive eutectic gel electrode patch (eutectic gel 13) prepared in Example 13 of this invention was tested, and the results are shown in [the table below]. Figure 9 .

[0217] The testing method is as follows: cut out three pieces of eutectic gel with a diameter of 10 mm and a thickness of 1 mm. Attach one side of each of the three pieces of eutectic gel directly to three button electrodes. One button electrode is used as the ground electrode, with the other side of the ground electrode attached to the protruding bone. The other two electrodes are used as the action electrodes, with their other sides directly attached to the direction of the muscle fibers.

[0218] from Figure 9 As can be seen, eutectic gels replace commercial electrodes as electrodes for electromyography (EMG) testing, and can collect electrical signals generated by muscles.

[0219] Example 7

[0220] The electrocardiogram (ECG) of the self-adhesive eutectic gel electrode patch (eutectic gel 13) prepared in Example 13 of this invention was tested, and the results are shown in [the table below]. Figure 10 .

[0221] The testing method is as follows: three pieces of eutectic gel with a diameter of 10 mm and a thickness of 1 mm are cut out. One side of each of the three pieces of eutectic gel is directly attached to three button electrodes. One of the button electrodes is used as the ground electrode, and the other side of the ground electrode is attached to the protruding bone. The other two electrodes are used as the action electrodes. The other side of one action electrode is directly attached to the fifth intercostal space of the left sternum, and the other side of the other action electrode is directly attached to the middle position of the line connecting the midpoint of the left clavicle and the nipple.

[0222] from Figure 10 As can be seen, eutectic gels can replace commercial electrodes as electrodes for ECG testing, and they can capture conventional ECGs.

[0223] Example 8

[0224] The electrooculography (EOG) of the self-adhesive eutectic gel electrode patch (eutectic gel 13) prepared in Example 13 of this invention was tested, and the results are shown in [the table below]. Figure 11 .

[0225] The testing method is as follows: Cut out three pieces of eutectic gel with a diameter of 10 mm and a thickness of 1 mm. Attach one side of each piece of eutectic gel directly to one of the three button electrodes. Use any one of the button electrodes as the ground electrode, with the other side of the ground electrode attached to the earlobe. Use the other two electrodes as the active electrodes. Attach the other side of one active electrode directly to a few centimeters above the eye, and the other active electrode directly to a few centimeters below the eye.

[0226] from Figure 11 As can be seen, eutectic gel, replacing commercial electrodes as electrodes for electrooculography (EOG) testing, can clearly display voltage changes during eye movements.

[0227] Example 9

[0228] The electroencephalogram (EEG) of the self-adhesive eutectic gel electrode patch (eutectic gel 13) prepared in Example 13 of this invention was tested, and the results are shown in [the table below]. Figure 12 .

[0229] The testing method is as follows: three pieces of eutectic gel with a diameter of 10 mm and a thickness of 1 mm are cut out. One side of each of the three pieces of eutectic gel is directly attached to three button electrodes. One of the button electrodes is used as the ground electrode, and the other side of the ground electrode is attached to the area with low muscle activity. The other two electrodes are used as the action electrodes, and their other sides are directly attached to a specific scalp area (such as the forehead). The potential of the specific scalp area relative to the ground electrode is measured.

[0230] from Figure 12 As can be seen, eutectic gels, replacing commercial electrodes as electrodes for EEG testing, capture electrical activity data of brain cells in specific brain regions. This data can be used to study normal brain activity in humans.

[0231] Example 10

[0232] The tensile properties, electrical conductivity and adhesion properties of the self-adhesive eutectic gel electrode patch (eutectic gel) prepared in this invention were measured, and the results are shown in Tables 1 to 4.

[0233] (1) Mechanical property testing (tensile properties)

[0234] Mechanical tests were conducted using a universal testing machine (model 2kN, CMT1203). Dumbbell-shaped specimens (55mm long, 3mm wide, and 3mm thick) were formed from the eutectic gel using a PTFE mold or a custom-made silicone mold, and both ends of the dumbbell-shaped specimens were attached to fixtures. The loading rate was kept constant at 200mm / min at room temperature, and the stress-strain test results were obtained (see Table 1).

[0235] (2) Conductivity test

[0236] Electrochemical impedance spectroscopy was obtained using an electrochemical workstation, and the conductivity was calculated using a formula. The eutectic gel was cut into circular slices with a diameter of 9 mm and a thickness of 1.5 mm. Then, the conductivity (σ) was calculated using the conductivity formula: σ = L / (RS), where L and S are the thickness (in mm) and cross-sectional area (in mm²) of the eutectic gel, respectively. 2 R is the resistance (unit: Ω), and the results are shown in Table 2.

[0237] The mechanical properties of the eutectic gel were determined at different temperatures using a high and low temperature mechanical testing machine. A dumbbell-shaped specimen with a length of 55 mm, a width of 3 mm, and a thickness of 3 mm was fixed onto a fixture and equilibrated for 30 min at temperatures of -40℃, -20℃, 0℃, 25℃, 40℃, and 60℃, respectively. Then, it was stretched using a mechanical testing machine at a stretching speed of 200 mm / min. The results of the high and low temperature mechanical tests are shown in Table 4.

[0238] (3) Adhesion performance test

[0239] The adhesion test was conducted using an overlap shear test method and a universal testing machine (model 2kN, CMT1203). The eutectic gel was cut into rectangular pieces 10mm long, 10mm wide, and 2mm thick. These pieces were then applied between two pieces of pigskin and pressed for 1 minute. The pigskin with the eutectic gel was then attached to a clamp. The loading rate was kept constant at 200mm / min at room temperature. The adhesion test results are shown in Table 5.

[0240] Table 1. Stress-strain test results of eutectic gels 1–24

[0241]

[0242]

[0243] Table 2. Conductivity test results of eutectic gels 9, 12-16

[0244] Eutectic Gel 9 0.86 Eutectic Gel 12 0.89 Eutectic Gel 13 1.08 Eutectic Gel 14 0.80 Eutectic Gel 15 0.71 Eutectic Gel 16 0.60

[0245] Table 3. Conductivity of eutectic gels 6, 8, and 11 at -40℃ to 60℃

[0246]

[0247]

[0248] Table 4. Stress-strain test results of eutectic gels 6, 8–11 at different temperatures.

[0249]

[0250] Table 5 Adhesion test results of eutectic gels 6, 8–11, and 17–24

[0251] Eutectic Gel 6 39 Eutectic Gel 8 41 Eutectic Gel 9 52 Eutectic Gel 10 43 Eutectic Gel 11 40 Eutectic Gel 17 20 Eutectic Gel 18 27 Eutectic Gel 19 23 Eutectic Gel 20 34 Eutectic Gel 21 30 Eutectic Gel 22 45 Eutectic Gel 23 48 Eutectic Gel 24 30

[0252] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A self-adhesive eutectic gel electrode patch, characterized in that, The raw materials are: carboxyl-containing monomers, polysaccharides, initiators, and solvents; The amount of the polysaccharide used is 1% of the mass of the carboxyl-containing monomer. The amount of the initiator used is 0.1-2.5% of the mass of the carboxyl-containing monomer. The carboxyl-containing monomer is acrylic acid; The solvent is a eutectic solvent, and the preparation method is as follows: choline chloride is dried in a vacuum oven at 80°C for 3 hours, and then the dried choline chloride and glycerol are heated and stirred at 90°C in a molar ratio of 1:2 until transparent to obtain the eutectic solvent. The amount of the carboxyl-containing monomer is 30% of the mass of the eutectic solvent; The polysaccharide is konjac glucomannan; The initiator is a redox initiator; The redox initiator includes an oxidant and a reducing agent; the oxidant is ammonium persulfate, and the reducing agent is a mixture of lignin and nano-silver.

2. A method for preparing the self-adhesive eutectic gel electrode patch according to claim 1, characterized in that, Includes the following steps: The carboxyl-containing monomer and polysaccharide were added to a eutectic solvent, stirred until homogeneous, and then an initiator was added and mixed until homogeneous to obtain a eutectic gel prepolymer solution. After spreading the eutectic gel prepolymer liquid, a crosslinking reaction is carried out to obtain the self-adhesive eutectic gel electrode patch.

3. The preparation method according to claim 2, characterized in that, The crosslinking reaction is carried out at room temperature, specifically at 20-30°C.

4. The application of the self-adhesive eutectic gel electrode patch of claim 1 as a medical auxiliary material.

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