Coix seed oil oat milk

Abstract

The present disclosure provides a coix seed oil oat milk, belonging to the technical field of food. The coix seed oil oat milk comprises oat and coix seed oil. The coix seed oil oat milk is obtained by enzymolysis and high-temperature cooking of oat to obtain a thick and rich beta-glucan milk, and then the milk is compounded with coix seed oil to obtain the product. The coix seed oil oat milk can obtain a milk with stable coix seed oil dissolution and difficult oxidation without adding emulsifiers, thickeners and stabilizers. The coix seed oil oat milk is mainly used for daily drinking of postoperative tumor patients.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of food and medicine, belongs to the field of food technology, and particularly relates to a coix seed oil oat milk. BACKGROUND

[0002] At present, coix seed oil is mainly researched in the aspects of anticancer and antitumor. The product development of coix seed oil at home and abroad is mainly concentrated in the research and development of cancer and antitumor drugs. Coix seed oil is usually applied together with radiotherapy and chemotherapy in the treatment of lung cancer, liver cancer, breast cancer and the like, obviously improves the treatment effect, reduces adverse reactions, and achieves the purpose of improving the immunity and quality of life of patients.

[0003] It is of great significance to provide a food and medicine for patients, which is easy to digest and absorb, has a protective effect on the gastrointestinal tract, and is used for adjusting the function of the body, improving the constitution, reducing symptoms, improving the quality of life of patients, and prolonging the survival period.

[0004] Coix seed oil is a fatty oil extracted from coix seed, which is usually prepared into soft capsules (such as coix seed oil soft capsules (gummy candies)) or injections (such as coix seed oil for injection) for use.

[0005] Oat milk is a plant milk prepared from oat as raw material. Oat contains soluble dietary fiber, and the main component is beta-glucan. Compared with animal milk such as milk, the plant milk is not smooth enough in taste, and the product is prone to stratification and oil-water separation, which affects the shelf life and the sensory quality of the product. SUMMARY

[0006] The present application provides a coix seed oil oat milk, which is easy to digest and absorb, has a protective effect on the gastrointestinal tract, does not add emulsifiers, and / or thickeners, and / or stabilizers, has good taste and flavor, and is a safe and healthy milk drink.

[0007] In order to achieve the above purpose, the present application adopts the following technical scheme:

[0008] A coix seed oil oat milk comprises the following raw materials in parts by weight: 5-50 parts of oat, and 1-8 parts of coix seed oil.

[0009] The oat is boiled with 10-500 parts of water and 0.01-1 part of high-temperature-resistant alpha-amylase to prepare oat milk slurry.

[0010] The foregoing coix seed oil oat milk can be prepared by the following method:

[0011] S1, 5-50 parts of oat is ground and uniformly mixed, 10-500 parts of water is boiled, and 0.01-1 part of high-temperature-resistant alpha-amylase is added, the temperature is kept at 99℃, and the water is boiled for 2-4 hours to obtain oat milk slurry;

[0012] S2, the oat milk slurry obtained in step S1 is sequentially treated by a colloid mill and a high-pressure homogenizer, and the temperature is controlled at 40-65 DEG C during the treatment to obtain stable and homogenized oat milk;

[0013] S3, 1-8 parts of coix seed oil is added to the oat milk of step S2, and sequentially treated by an emulsifying shear machine and a high-pressure homogenizer, and then high-temperature instantaneous sterilization is performed, the temperature of the high-temperature instantaneous sterilization is 110-140 DEG C, and the time is 1-30 s, and the coix seed oil oat milk is obtained by filling.

[0014] The homogenization pressure of the high-pressure homogenization treatment in step S3 is 30-50 MPa, and the homogenization times is 2 times; the homogenization pressure of the high-pressure homogenization treatment in step S4 is 30-50 MPa, and the homogenization times is 2 times.

[0015] The coix seed oil oat milk does not contain emulsifiers, and / or thickeners, and / or stabilizers.

[0016] The coix seed oil oat milk is used for daily drinking of anti-tumor population.

[0017] The coix seed oil oat milk is used for daily drinking of postoperative tumor population.

[0018] The technical scheme of the present application has the following advantages:

[0019] 1. Coix seed oil has adverse effects on the digestive system, is difficult to dissolve in dairy products, and is easy to oxidize. In milk drinks, the following techniques are usually used to solve the problem of oil dissolution:

[0020] 1) Use emulsifiers and thickeners. Emulsifiers or thickeners can improve dissolution or promote dispersion.

[0021] 2) Use stabilizers. Stabilizers can help maintain the emulsified state of oil and water and prevent separation.

[0022] 3) High-temperature treatment. During production, heating the beverage to a certain temperature can make the oil more easily mixed with other ingredients, increasing the solubility of the oil.

[0023] In the present application, part of the oats is subjected to high-temperature cooking and starch enzyme hydrolysis, and then compounded with coix seed oil to form a stable beverage system, ensuring the stability of coix seed oil dissolution in milk drinks, without the need for additional emulsifiers, thickeners, or stabilizers.

[0024] 2. In the coix seed oil oat milk of the present application, the high-temperature cooking of oats can obtain a thick solution rich in beta-glucan, which has a protective effect on the gastrointestinal tract, eliminating the adverse effects of coix seed oil on the digestive system.

[0025] 3. The coaction of the coix seed oil and the oat improves the effect on the human immune system, but the coix seed oil has the problems of difficult dissolution in dairy products and easy oxidation. The coix seed oil oat milk provided by the present application realizes the preparation of the coix seed oil into the daily milk beverage.

[0026] 4. The coix seed oil oat milk has good taste, slightly sweet taste and rich taste, and good stability, and can be stored for more than 3 months without separation.

[0027] 5. The present application provides the coix seed oil oat milk, which is prepared from the coix seed oil and the oat into the milk beverage that can be used daily, and can be used for long-term drinking by the tumor patients, especially the tumor postoperative patients. BRIEF DESCRIPTION OF DRAWINGS

[0028] In order to more clearly illustrate the technical solutions of the embodiments of the present application or the prior art, the drawings needed to be used in the embodiments or the prior art description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0029] Figure 1 The color and material state photos of the beverage placed in the constant temperature and humidity box under the condition of temperature 40±2℃ and humidity 70%±5% for the first month are shown, wherein (a), (b), (c), (d), (e), (f), (g) correspond to example 1, 2, 3, comparative example 1, 2, 3, 4 groups respectively.

[0030] Figure 2 The color and material state photos of the beverage placed in the constant temperature and humidity box under the condition of temperature 40±2℃ and humidity 70%±5% for the third month are shown, wherein (a), (b), (c), (d), (e), (f), (g) correspond to example 1, 2, 3, comparative example 1, 2, 3, 4 groups respectively.

[0031] Figure 3 The color and material state photos of the beverage placed in the constant temperature and humidity box under the condition of temperature 40±2℃ and humidity 70%±5% for the sixth month are shown, wherein (a), (b), (c) correspond to example 1, 2, 3 respectively.

[0032] Figure 4The effects of each group on the serum IL-2 (interleukin-2), IFN-γ (gamma interferon) and TNF-α (tumor necrosis factor-α) levels of MFC gastric cancer tumor-bearing mice are shown, wherein (a), (b), (c) correspond to the contents of IL-2, IFN-γ and TNF-α in the serum of each group of MFC gastric cancer tumor-bearing mice after 10 days of administration, respectively. *** indicates P<0.001 compared with the model group; ### indicates P<0.001 compared with the blank control group. DETAILED DESCRIPTION

[0033] The technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0034] Embodiment 1

[0035] Components: parts by weight, oat 5 parts, coix seed oil 1 part, alpha-amylase 0.01 part, water 90 parts.

[0036] Preparation:

[0037] 1) Take 5 parts of oat powder and add 90 parts of water to boil, and add 0.01 parts of high-temperature-resistant alpha-amylase, and keep boiling for 2 hours.

[0038] 2) The whole material obtained in step 1 is treated in sequence by colloid mill and high-pressure homogenizer, the homogenization pressure is 30 MPa, the homogenization times is 2 times, and after completion, the temperature is controlled at 45℃.

[0039] 3) Add 1 part of coix seed oil to step 2, and treat it in sequence by emulsifying shear machine and high-pressure homogenizer, the homogenization pressure is 30 MPa, the homogenization times is 2 times, and after completion, it is treated by high-temperature instantaneous sterilization, the temperature is controlled at 110℃, and the time is 15s.

[0040] 4) The solution in step 3 is filled in the form of Kangmei bag to show the finished product.

[0041] Embodiment 2

[0042] Components: parts by weight, oat 50 parts, coix seed oil 8 parts, alpha-amylase 1 part, water 500 parts.

[0043] Preparation:

[0044] 1) Take 50 parts of oat powder and add 500 parts of water to boil, and add 1 part of high-temperature-resistant alpha-amylase, and keep boiling for 3 hours.

[0045] 2) The whole material obtained in step 1 is sequentially treated by colloid mill and high-pressure homogenizer, the homogenization pressure is 36 MPa, the homogenization times is 2, after completion, the temperature is controlled at 50℃.

[0046] 3) 8 parts of coix seed oil is added into step 2, sequentially treated by emulsification shear machine and high-pressure homogenizer, the homogenization pressure is 36 MPa, the homogenization times is 2, after completion, high-temperature instantaneous sterilization is carried out, the temperature is controlled at 120℃, the time is 10s.

[0047] 4) The solution in step 3 is filled and displayed as finished product in the form of a KANGMEI bag.

[0048] Example 3:

[0049] Components: parts by weight, oat 38 parts, coix seed oil 6 parts, alpha-amylase 0.5 parts, water 200 parts.

[0050] Preparation:

[0051] 1) 38 parts of oat is powdered, 200 parts of water is boiled, and 0.5 parts of high-temperature resistant alpha-amylase is added, and boiled for 4 hours.

[0052] 2) The whole material obtained in step 1 is sequentially treated by colloid mill and high-pressure homogenizer, the homogenization pressure is 45 MPa, the homogenization times is 2, after completion, the temperature is controlled at 55℃.

[0053] 3) 6 parts of coix seed oil is added into step 2, sequentially treated by emulsification shear machine and high-pressure homogenizer, the homogenization pressure is 45 MPa, the homogenization times is 2, after completion, high-temperature instantaneous sterilization is carried out, the temperature is controlled at 121℃, the time is 8s.

[0054] 4) The solution in step 3 is filled and displayed as finished product in the form of a KANGMEI bag.

[0055] Comparative Example 1:

[0056] Components: parts by weight, coix seed 38 parts, coix seed oil 6 parts, alpha-amylase 0.5 parts, water 200 parts.

[0057] Preparation:

[0058] 1) 38 parts of coix seed is powdered, 200 parts of water is boiled, and 0.5 parts of high-temperature resistant alpha-amylase is added, and boiled for 3 hours.

[0059] 2) The whole material obtained in step 1 is sequentially treated by colloid mill and high-pressure homogenizer, the homogenization pressure is 30 MPa, the homogenization times is 2, after completion, the temperature is controlled at 45℃.

[0060] 3) 6 parts of coix seed oil is added in step 2, and is sequentially processed by emulsification shearing machine and high-pressure homogenizer, the homogenization pressure is 30 MPa, the homogenization times is 2 times, after completion, high-temperature instantaneous sterilization is carried out, the temperature is controlled at 121 DEG C, and the time is 8 s.

[0061] 4) The solution in step 3 is filled in a Kangmei bag to show the finished product.

[0062] Comparative example 2:

[0063] Components: parts by weight, oat 38 parts, coix seed oil 6 parts, whole milk powder 3 parts, sugar 3 parts, water 200 parts.

[0064] Preparation:

[0065] 1) 38 parts of oat is boiled with 200 parts of water, and is milled at 20 DEG C for 10 min, after milling, it is passed through an 80-mesh screen to prepare oat coarse pulp, then 3 parts of sugar is added and mixed, and the temperature is controlled at 55 DEG C after completion.

[0066] 2) 3 parts of whole milk powder and 6 parts of coix seed oil are added in step 1, and are sequentially processed by emulsification shearing machine and high-pressure homogenizer, the homogenization pressure is 45 MPa, the homogenization times is 2 times, after completion, high-temperature instantaneous sterilization is carried out, the temperature is controlled at 121 DEG C, and the time is 8 s.

[0067] 3) The solution in step 2 is filled in a Kangmei bag to show the finished product.

[0068] Comparative example 3:

[0069] Components: parts by weight, oat 38 parts, coix seed oil 6 parts, whole milk powder 3 parts, sugar 3 parts, water 200 parts.

[0070] Preparation:

[0071] 1) 38 parts of oat, 3 parts of sugar and 200 parts of water are mixed, and are sequentially processed by colloid mill and high-pressure homogenizer, the homogenization pressure is 45 MPa, the homogenization times is 2 times, after completion, the temperature is controlled at 55 DEG C.

[0072] 2) 3 parts of whole milk powder and 6 parts of coix seed oil are added in step 1, and are sequentially processed by emulsification shearing machine and high-pressure homogenizer, the homogenization pressure is 45 MPa, the homogenization times is 2 times, after completion, high-temperature instantaneous sterilization is carried out, the temperature is controlled at 121 DEG C, and the time is 8 s.

[0073] 3) The solution in step 2 is filled in a Kangmei bag to show the finished product.

[0074] Comparative example 4:

[0075] Components: parts by weight, soybean 38 parts, coix seed oil 6 parts, alpha-amylase 0.5 parts, water 200 parts.

[0076] Preparation:

[0077] 1) 38 parts of soybean powder were boiled with 200 parts of water and 0.5 parts of thermostable alpha-amylase was added, and boiled for 3 hours.

[0078] 2) The whole material obtained in step 1 was sequentially treated by colloid mill, filtration, and high-pressure homogenizer, the homogenization pressure was 30 MPa, and the homogenization times was 2 times, after completion, the temperature was controlled at 45℃.

[0079] 3) 6 parts of yiyi oil was added to step 2, sequentially treated by emulsification shear machine and high-pressure homogenizer, the homogenization pressure was 30 MPa, and the homogenization times was 2 times, after completion, high-temperature instantaneous sterilization was carried out, the temperature was controlled at 121℃, and the time was 8s.

[0080] 4) The solution in step 3 was filled into a Kangmei bag to show the finished product.

[0081] Beverage stability test

[0082] The above beverages of examples 1, 2, 3, comparative examples 1, 2, 3, and 4 were placed in a constant temperature and humidity box, and observed for 6 months under the conditions of temperature 40±2℃ and humidity 70%±5%, the sugar degree, color, material state, flavor and triglyceride changes were recorded and detected every 3 months, and the stability of the beverages during storage was evaluated through these tests.

[0083] 1. Color and material state

[0084] The sample was taken in a transparent bowl, the color and whether the material was layered were observed, and the photograph was compared with the previously stored photograph.

[0085] (1) Color and material state of each sample at the 0th month

[0086] The results showed that the color of each sample at the 0th month was in the order of example 1 < comparative example 4 < example 3 < comparative example 1 < example 2 < comparative example 2 < comparative example 3 from light to dark, and the material system was uniform. See the attached Figure 1 .

[0087] (2) Color and material state of each sample at the 3rd month

[0088] The results showed that the color of each sample at the 3rd month was in the order of example 1 < example 3 < comparative example 2 < comparative example 1 < comparative example 4 < comparative example 3 < example 2 from light to dark.

[0089] At the 3rd month, examples 1, 2, and 3 were not layered, and the layering of comparative examples was in the order of comparative example 3 < comparative example 2 < comparative example 1 < comparative example 4 from light to heavy. See the attached Figure 2 .

[0090] (3) Color and material state of each sample at the 6th month

[0091] The results show that the 6th month of Example 1, 2, 3 still does not appear delamination, and the stability test is passed. See the attached Figure 3 .

[0092] 2. Flavor

[0093] When there is no obvious change in color and material state, sample in a 30 mL tasting cup, smell the sample smell and taste the sample taste. The sensory evaluation refers to the "National Food Safety Standard Beverage (GB 7101-2022)". The evaluation results are shown in Table 1.

[0094] Table 1: Flavor evaluation results

[0095]

[0096] After flavor comparison, it is considered that Example 3 is the best, and the viscosity can be appropriately reduced to further improve the taste.

[0097] 3. Triglyceride content

[0098] The triglyceride content of each group of samples at the 0th month, 3rd month, and 6th month was determined according to the pharmacopoeia method, and the decrease of triglyceride at the 3rd month and 6th month. The results are shown in Table 2.

[0099] The calculation formula of the decrease is:

[0100] Decrease (%) = (original value - present value) / original value * 100%

[0101] Table 2: Triglyceride content (mg / mL)

[0102]

[0103] The results show that with the increase of storage time, the triglyceride content of each group decreases, among which the decrease of Example 3 is the smallest, indicating that the degree of oil oxidation in Example 3 is the lightest, i.e. the protection of Example 3 to oil oxidation is the best.

[0104] Based on the above experimental results, Example 3 has excellent stability, followed by Example 2 and Example 1. That is, through the experimental method of the present patent, the system can be maintained stable without adding emulsifiers and stabilizers.

[0105] Verification test

[0106] 1. Establishment, grouping and administration method of mouse gastric cancer model

[0107] MFC gastric cancer cells were cultured in RPMI-1640 medium containing 10% calf serum under conventional conditions (37℃, saturated humidity, 5% CO2) to the logarithmic growth phase, and the cell density was adjusted to 1×107 ml -1 C57BL / 6 mice were inoculated with 0.2 mL of MFC cell suspension in the right axillary after 75% ethanol disinfection to establish MFC gastric cancer tumor-bearing mouse models. The mice were randomly divided into blank control group, model group, example 1, 2, 3 group, comparative example 1, 2, 3, 4 group, 6 in each group. The day after grouping, the drug was given: (1) Example, comparative example: 1.25 g / kg, diluted with normal saline to 0.25 ml / each, (2) blank control group, model group: given normal saline 0.25 ml / each. Once a day, for 10 days, the mice were sacrificed on the 10th day.

[0108] 2. Peripheral blood IL-2 (interleukin-2), IFN-γ (interferon-γ) and TNF-α (tumor necrosis factor-α) level detection

[0109] The mouse blood was separated by orbital venous plexus blood collection method, and 100 μL of serum was separated by centrifugation; according to the operation guide in the ELISA kit instruction manual, the levels of IL-2, IFN-γ and TNF-α were detected.

[0110] By detecting the expression levels of IFN-γ, IL-2 and TNF-α in the serum of each group of mice, we found that compared with the blank control group, the levels of IFN-γ, IL-2 and TNF-α in the model group mice were significantly decreased (P<0.001). Compared with the model group, the levels of IFN-γ, IL-2 and TNF-α in the serum of example and comparative example mice were significantly increased (P<0.001), which indicated that the diet therapy product could promote the production of cytokines in MFC gastric cancer tumor-bearing mice and form an immune microenvironment. The contents of IL-2, IFN-γ and TNF-α of example 3 were the highest, followed by example 2 and example 1. The levels of IL-2, IFN-γ and TNF-α of example groups were better than those of comparative examples, and the levels of IL-2, IFN-γ and TNF-α of comparative example 2 and comparative example 3 were better than those of comparative example 4 and comparative example 1. (See Figure 4 )

[0111] The above is only a specific embodiment of the present application, but the protection scope of the present application is not limited thereto, any skilled person in the art can easily think of changes or replacements within the technical range disclosed by the present application, which should be covered within the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A coix seed oil oat milk, characterized by, The raw materials include, by weight, 1-8 parts of coix seed oil and 5-50 parts of oat; The oat 5-50 parts is enzymatically hydrolyzed into oat milk by adding 10-500 parts of water and 0.01-1 part of high-temperature-resistant alpha-amylase; The coix seed oil oat milk is prepared by the following method: S1, 5-50 parts of oat is powdered and mixed, 10-500 parts of water is boiled, and 0.01-1 part of high-temperature-resistant alpha-amylase is added to enzymatically hydrolyze oat milk; S2, the oat milk obtained in step S1 is sequentially treated by colloid mill and high-pressure homogenizer to obtain stable and homogeneous oat milk; S3, 1-8 parts of coix seed oil is added to the oat milk in step S2, and sequentially treated by emulsifying shear machine and high-pressure homogenizer to obtain coix seed oil oat milk; The coix seed oil oat milk does not contain emulsifier, thickener and / or stabilizer.

2. The oil of seed of Fructus comi oat milk according to claim 1, characterized in that, The water boiling temperature in step S1 is 99℃, and the water boiling time is 2-4 hours.

3. The oil of seed of Fructus comi and oat milk according to claim 1, characterized in that, The temperature control of the colloid mill and high-pressure homogenizer treatment process in step S2 is 40-65℃.

4. The oil of seed of Fructus comi and oat milk according to claim 1, characterized in that, After step S3, a high-temperature instant sterilization step is further included, the high-temperature instant sterilization temperature is 110-140℃, and the time is 1-30s.

5. The oil of seed of Fructus comi oat milk according to any one of claims 1 to 4, characterized in that, It is used for daily drinking of postoperative tumor population.

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