Hollow fiber membrane woven mat and oxygenator

Abstract

This invention provides a hollow fiber membrane woven mat, comprising multiple first and second hollow fiber membranes. The multiple first hollow fiber membranes are arranged parallel to each other and spaced apart, thereby forming multiple first gaps. Multiple second hollow fiber membranes are also arranged parallel to each other and spaced apart, thereby forming multiple second gaps. The first and second hollow fiber membranes are intersected, thereby forming multiple first intersection points. The multiple second hollow fiber membranes are arranged sequentially along the length of the first hollow fiber membrane, alternating between inner and outer sections, so that at each of the first intersection points, the multiple second hollow fiber membranes form multiple alternating first inner and outer protrusions. This hollow fiber membrane woven mat eliminates the need for weaving yarn, and through a specific weaving method of the multiple hollow fiber membranes, solves problems such as clogging and large transmembrane pressure differentials that occur during long-term use. This invention also provides an oxygenator.

Description

[0001] This invention claims priority to Chinese Patent Application No. 202211194057.0, filed on September 28, 2022, entitled "Hollow Fiber Membrane Braided Mat and Hollow Fiber Membrane Assembly", the entire contents of which are incorporated herein by reference. Technical Field

[0002] This invention relates to the field of medical device technology, and in particular to a hollow fiber membrane woven pad and an oxygenator. Background Technology

[0003] Hollow fiber membranes possess a large specific surface area and self-supporting structure, resulting in high packing density per unit volume. Their production and assembly into membrane modules offer high scalability. Industrially, they can be widely applied in environmental protection, biomedicine, chemical, and food industries. However, after the hollow fiber membrane is prepared, it needs to be used to prepare modules. Hollow fiber membrane modules prepared using traditional methods suffer from uneven hydrodynamic distribution, low membrane utilization, poor filtration efficiency, and susceptibility to clogging over prolonged use. This is particularly problematic in the medical field, leading to short module lifespan and adverse effects such as plasma leakage in artificial lung applications.

[0004] Therefore, it is crucial to organize the membrane fibers before module casting, such as by using densely packed multiple membrane fibers or warp knitting methods to ensure a uniform distribution of thousands of hollow fiber membranes. For example, using double-woven yarns to cross-weave the hollow fiber membrane into a membrane-forming pad is an option; however, this technique causes the weaving angle to decrease over time, making it unsuitable for long-term use. Another approach is to use a single-thread needle-locking method to weave the hollow fiber membrane; however, modules made from membrane-forming pads woven using this technique may experience clogging and large transmembrane pressure differentials after prolonged use.

[0005] It should be noted that the information disclosed in the background section of this invention is intended only to enhance the understanding of the general background of this invention, and should not be construed as an admission or in any way implying that the information constitutes prior art known to those skilled in the art. Summary of the Invention

[0006] This invention provides a hollow fiber membrane woven mat that does not require the use of weaving yarn, but is woven solely from hollow fiber membrane. It can also reduce the amount of raw materials used, increase the filling density of hollow fiber membrane, improve the utilization rate of hollow fiber membrane, and extend the service life of hollow fiber membrane woven mat.

[0007] In addition, the present invention also provides an oxygenator in which the hollow fiber membrane woven pad does not require the use of braiding yarn, but is woven only from hollow fiber membrane, which is beneficial to improving the packing density and oxygenation efficiency of the oxygenator.

[0008] In one aspect, the present invention provides a hollow fiber membrane woven mat, comprising a plurality of first hollow fiber membranes and a plurality of second hollow fiber membranes. The plurality of first hollow fiber membranes are arranged parallel to each other and spaced apart, thereby forming a plurality of first gaps. The plurality of second hollow fiber membranes are arranged parallel to each other and spaced apart, thereby forming a plurality of second gaps. The first hollow fiber membranes and the second hollow fiber membranes are arranged intersectingly, thereby forming a plurality of first intersection points. The plurality of second hollow fiber membranes are arranged sequentially along the length direction of the first hollow fiber membranes and alternately arranged inside and outside, so that the plurality of second hollow fiber membranes form a plurality of alternately arranged first inner protrusions and first outer protrusions at each first intersection point along the length direction of the first hollow fiber membranes.

[0009] In some embodiments of this application, the width of at least one of the plurality of first gaps is greater than or equal to the width of at least one of the plurality of first hollow fiber membranes; the width of at least one of the plurality of second gaps is greater than or equal to the width of the second hollow fiber membrane; and / or,

[0010] The width of the first gap between any two adjacent first hollow fiber membranes is equal, and the width of the second gap between any two adjacent second hollow fiber membranes is equal.

[0011] In some embodiments of this application, the intersection angle between the first hollow fiber membrane and the second hollow fiber membrane is equal to 90°; the hollow fiber membrane woven pad further includes multiple third hollow fiber membranes, with one third hollow fiber membrane disposed between any two adjacent first hollow fiber membranes, the length direction of the third hollow fiber membrane being parallel to the length direction of the first hollow fiber membrane, and a third gap forming between the third hollow fiber membrane and the adjacent first hollow fiber membrane, the width of the third gap being greater than 0 and less than the width of the first gap; the third hollow fiber membrane and the second hollow fiber membrane are intersected, thereby forming multiple second intersection points, and the multiple second hollow fiber membranes are arranged sequentially along the length direction of the third hollow fiber membrane, alternating inside and outside, at each second intersection point, the alternating inside and outside sequence formed by the multiple second hollow fiber membranes along the length direction of the third hollow fiber membrane is opposite to the alternating inside and outside sequence formed along the length direction of the first hollow fiber membrane, so that the second hollow fiber membrane forms multiple alternating second outward protrusions and second inward protrusions at each second intersection point.

[0012] In some embodiments of this application, for any second hollow fiber membrane, the alternation sequence of its inner and outer parts at the first intersection point is the same as that of each first hollow fiber membrane, and the alternation sequence of its inner and outer parts at the second intersection point is the same as that of each third hollow fiber membrane, but the alternation sequence of the inner and outer parts of the second hollow fiber membrane at the first intersection point and the second intersection point is reversed.

[0013] In some embodiments of this application, the width of the third gap between any two adjacent first hollow fiber membranes and the third hollow fiber membrane is 1 mm to 15 mm, and the width of the second gap between any two adjacent second hollow fiber membranes is 1 mm to 15 mm.

[0014] In some embodiments of this application, the intersection angle between the first hollow fiber membrane and the second hollow fiber membrane is not equal to 90°; the hollow fiber membrane woven pad further includes multiple third hollow fiber membranes, which are parallel to each other and spaced apart along the length direction of the second hollow fiber membrane, and intersect with the second hollow fiber membrane at an angle equal to or not equal to 90°, and the multiple third fiber membranes are alternately arranged inside and outside along the length direction of the first hollow fiber membrane, and the third hollow fiber membranes intersect with the second hollow fiber membrane, thereby forming multiple second intersection points, and the first intersection point coincides with the second intersection point.

[0015] In some embodiments of this application, along the length of any hollow fiber membrane, multiple intersections formed on the hollow fiber membrane cause the hollow fiber membrane to be arranged in an alternating inner and outer sequence.

[0016] In some embodiments of this application, at least one of the first hollow fiber membrane, the second hollow fiber membrane, and the third hollow fiber membrane has an outer diameter of 300 μm to 2000 μm, and at least one of the first hollow fiber membrane, the second hollow fiber membrane, and the third hollow fiber membrane has a thickness of 80 μm to 100 μm; and / or, the width of the first gap between any two adjacent first hollow fiber membranes is 1 mm to 15 mm.

[0017] In another aspect, the present invention also provides an oxygenator, comprising:

[0018] The housing includes an air inlet chamber at one end, an air outlet chamber at the other end, and an exchange chamber between the air inlet chamber and the air outlet chamber, the exchange chamber being provided with a blood inlet and a blood outlet;

[0019] As described above, the hollow fiber membrane woven mat is disposed within the exchange chamber; and

[0020] The encapsulation section seals both ends of the hollow fiber membrane woven pad with the inner wall of the exchange chamber through the encapsulation section, so that the air inlet chamber and the air outlet chamber are connected through the hollow hole structure of the multiple first hollow fiber membranes and / or the multiple second hollow fiber membranes.

[0021] In some embodiments of this application, the hollow fiber membrane braided pad is wound and disposed in the exchange chamber, and the axial direction of the plurality of first hollow fiber membranes or the plurality of second hollow fiber membranes connected to the encapsulation part is a first direction, and the axial direction of the wound hollow fiber membrane braided pad is the same as the first direction; or,

[0022] The hollow fiber membrane woven pad is laid flat in the exchange chamber. The first hollow fiber membrane includes a first end and a second end opposite to each other, and the second hollow fiber membrane includes a third end and a fourth end opposite to each other. The first end of each first hollow fiber membrane and the third end of each second hollow fiber membrane are connected to the air inlet chamber, and the second end of each first hollow fiber membrane and the fourth end of each second hollow fiber membrane are connected to the air outlet chamber. Attached Figure Description

[0023] Figure 1 A partial structural schematic diagram of the hollow fiber membrane woven mat provided in the first embodiment of the present invention;

[0024] Figure 2 A partial structural schematic diagram of the hollow fiber membrane woven mat provided in the second embodiment of the present invention;

[0025] Figure 3 This is a schematic diagram of the structure of an oxygenator provided in one embodiment of the present invention;

[0026] Figure 4 A schematic diagram of an oxygenator provided for another embodiment of the present invention.

[0027] The reference numerals in the attached figures are explained as follows:

[0028] 10, 20: Hollow fiber membrane woven mat;

[0029] 100: First hollow fiber membrane; 101: First end; 102: Second end; 200: Second hollow fiber membrane; 201: Third end; 202: Fourth end; 300: Third hollow fiber membrane; 410: First outward convex portion; 405: First inward convex portion; 408: First intersection point; 420: Second outward convex portion; 425: Second inward convex portion; 428: Second intersection point;

[0030] 50: Oxygenator;

[0031] 51: Housing; 510: Air inlet chamber; 520: Air outlet chamber; 530: Exchange chamber; 52: Encapsulation part; 521: Glue encapsulation part; 522: First partition; 523: Second partition; 501: Air inlet; 502: Air outlet; 503: Blood inlet; 504: Blood outlet. Detailed Implementation

[0032] The hollow fiber membrane woven mat and oxygenator proposed in this invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. The advantages and features of this invention will become clearer from the following description. It should be noted that the drawings are in a very simplified form and use non-precise proportions, only for the purpose of conveniently and clearly illustrating the embodiments of this invention. Please refer to the drawings to make the objectives, features, and advantages of this invention more apparent and understandable. It should be understood that the structures, proportions, sizes, etc., depicted in the accompanying drawings are only for the purpose of assisting those skilled in the art in understanding and reading the content disclosed in the specification, and are not intended to limit the implementation conditions of this invention. Any modifications to the structure, changes in proportions, or adjustments to the size, if they are the same as or similar to the effects and objectives achieved by this invention, should still fall within the scope of the technical content disclosed in this invention. Specific design features of the invention disclosed herein, including, for example, specific dimensions, orientations, positions, and shapes, will be determined in part by the specific application and usage environment. Furthermore, in the embodiments described below, the same reference numerals are sometimes used across different drawings to denote the same parts or parts having the same function, and repeated descriptions are omitted. In this specification, similar reference numerals and letters are used to denote similar items; therefore, once an item is defined in one figure, it need not be discussed further in subsequent figures. Furthermore, if the methods described herein involve a series of steps, and the order of these steps presented herein is not necessarily the only possible order in which they can be performed, some of the described steps may be omitted and / or other steps not described herein may be added to the method.

[0033] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element. The singular forms “a,” “an,” and “the” include plural objects. The term “or” is generally used to mean “and / or,” the term “several” is generally used to mean “at least one,” and the term “at least two” is generally used to mean “two or more.” Furthermore, the terms “first,” “second,” and “third” are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated.

[0034] In the description of this invention, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "axial," "radial," and "circumferential" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this invention and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0035] In the description of this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0036] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of the second feature includes the first feature directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature includes the first feature directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0037] Furthermore, in the description of this specification, the reference to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., means that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in a suitable manner in any one or more embodiments or examples. Furthermore, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0038] The core idea of ​​this invention is to provide a hollow fiber membrane woven mat and a hollow fiber membrane module, which can reduce the amount of raw materials used, increase the hollow fiber membrane packing density, improve the utilization rate of hollow fiber membrane, and extend the service life of the hollow fiber membrane woven mat and the hollow fiber membrane module.

[0039] To achieve the above-mentioned goals, this invention provides a hollow fiber membrane woven mat. Please refer to [reference needed]. Figure 1 The diagram illustrates a partial structural schematic of the hollow fiber membrane woven mat provided in the first embodiment of the present invention.

[0040] like Figure 1As shown, the hollow fiber membrane woven mat 10 provided in this embodiment includes multiple first hollow fiber membranes 100 and multiple second hollow fiber membranes 200. The multiple first hollow fiber membranes 100 are arranged parallel to each other and spaced apart, thereby forming a first gap between any two adjacent first hollow fiber membranes 100; the width of the first gap is greater than, less than or equal to the width of the first hollow fiber membrane 100 (i.e., the outer diameter of the first hollow fiber membrane 100); the multiple second hollow fiber membranes 200 are arranged parallel to each other and spaced apart, thereby forming a second gap between any two adjacent second hollow fiber membranes 200; the width of the second gap is greater than, less than or equal to the width of the second hollow fiber membrane 200 (i.e., the outer diameter of the second hollow fiber membrane 200).

[0041] The first hollow fiber membrane 100 and the second hollow fiber membrane 200 are intersected, thereby forming a plurality of first intersection points 408 (i.e., intersection points of the first hollow fiber membrane 100 and the second hollow fiber membrane 200). The plurality of second hollow fiber membranes 200 are arranged sequentially along the length direction of the first hollow fiber membrane 100 and alternately arranged inside and outside, so that the plurality of second hollow fiber membranes 200 form a plurality of alternately arranged first inner protrusions 405 and first outer protrusions 410 at each first intersection point 408 along the length direction of the first hollow fiber membrane 100.

[0042] It should be noted that, as those skilled in the art will understand, when the second hollow fiber membrane 200 is disposed inward relative to the first hollow fiber membrane 100 (i.e., the second hollow fiber membrane 200 is away from the observer relative to the first hollow fiber membrane 100), the second hollow fiber membrane 200 can form a first inward protrusion 405 due to the obstruction of the first hollow fiber membrane 100, for example... Figure 1 The portion of the second hollow fiber membrane 200 that is obscured by the first hollow fiber membrane 100; when the second hollow fiber membrane 200 is positioned outward relative to the first hollow fiber membrane 100 (i.e., when the second hollow fiber membrane 200 is closer to the observer relative to the first hollow fiber membrane 100), the second hollow fiber membrane 200 can form a first outward protrusion 410 by obscuring the first hollow fiber membrane 100, for example... Figure 1 The portion of the second hollow fiber membrane 200 that covers the first hollow fiber membrane 100.

[0043] like Figure 1As shown, when the orientation of the woven mat is fixed, the second hollow fiber membrane 200 forms a first "outer protrusion" 410 in the extending direction of the first hollow fiber membrane 100, that is, the intersection of the second hollow fiber membrane 200 and the first hollow fiber membrane 100. At this intersection point, the first hollow fiber membrane 100 is away from the observer, while the second hollow fiber membrane 200 is close to the observer, such that the first hollow fiber membrane 100 is located below the woven mat at this intersection point. Similarly, those skilled in the art can understand the "inner protrusion" 405 accordingly.

[0044] Because the hollow fiber membrane woven pad provided by the present invention has multiple alternating first inner protrusions 405 and first outer protrusions 410 at each first intersection point 408 due to the cross arrangement of multiple second hollow fiber membranes 200 with the first hollow fiber membrane 100 along the length direction of the first hollow fiber membrane 100, it can prevent the hollow fiber membranes in the hollow fiber membrane assembly prepared by winding the hollow fiber membrane woven pad provided by the present invention or by other methods from overlapping, so that the hollow fiber membrane woven pad provided by the present invention can be directly wound into a bundle to form a hollow fiber membrane assembly.

[0045] Compared to the traditional method of forming a single-layer hollow fiber membrane pad from hollow fiber membrane and braided yarn, which requires beveling at an angle to create a bending angle, then rewinding the membrane pad twice to form a double-layer membrane pad cross product, and finally winding it into a hollow fiber membrane assembly, the hollow fiber membrane braided pad provided by this invention can be directly formed in one step. This effectively reduces the damage to the hollow fiber membrane caused by traditional processes and effectively reduces the risk of plasma leakage.

[0046] Furthermore, since the hollow fiber membrane braided pad provided by this invention does not require the use of braided yarn, it can reduce the impact of other introduced materials on the compatibility of human blood, effectively avoid the risk of thrombosis caused by the braided thread locking the hollow fiber membrane, effectively prevent scratches on the surface of the hollow fiber membrane, and also effectively increase the packing density of the hollow fiber membrane, thereby increasing the blood oxygen exchange capacity, reducing the blood prefilling volume, and reducing the risk of blood exposure.

[0047] It should be noted that, as those skilled in the art will understand, since the plurality of first hollow fiber membranes 100 and the plurality of second hollow fiber membranes 200 in the hollow fiber membrane woven pad provided by the present invention are all spaced apart, it can be ensured that a suitable gap can be formed between adjacent first hollow fiber membranes 100 and adjacent second hollow fiber membranes 200, so that the medium can pass through the gap, effectively avoiding blockage of the hollow fiber membrane assembly made by winding the hollow fiber membrane woven pad provided by the present invention during use, thereby ensuring smooth flow in the internal channels of the first hollow fiber membrane 100 and the second hollow fiber membrane 200.

[0048] Preferably, the plurality of first hollow fiber membranes 100 are arranged at equal intervals, and the plurality of second hollow fiber membranes 200 are also arranged at equal intervals. That is, the distance between any adjacent first hollow fiber membranes 100 is equal, i.e., the width of the first gap is equal, and the distance between any adjacent second hollow fiber membranes 200 is also equal, i.e., the width of the second gap is equal. This arrangement ensures that the plurality of first hollow fiber membranes 100 and the plurality of second hollow fiber membranes 200 are uniformly distributed. Therefore, after the hollow fiber membrane woven pad provided by this invention is wound into a bundle, a uniform hollow fiber membrane bundle can be obtained, which allows the fluid to pass through the flow channel uniformly, effectively improving the utilization rate of the hollow fiber membrane and extending the service life of the hollow fiber membrane assembly made using the hollow fiber membrane woven pad provided by this invention.

[0049] Please continue to refer to this. Figure 1 ,like Figure 1 As shown, in this embodiment, the intersection angle between the first hollow fiber membrane 100 and the second hollow fiber membrane 200 is equal to 90°. This makes it easier to weave the hollow fiber membrane woven mat provided by the present invention.

[0050] Preferably, the plurality of first hollow fiber membranes 100 are arranged uniformly along a first direction, and the plurality of second hollow fiber membranes 200 are arranged uniformly along a second direction, wherein the first direction is perpendicular to the second direction. For example Figure 1 The first direction is the arrangement direction of the first hollow fiber membrane 100, i.e., the warp direction; the second direction is the arrangement direction of the second hollow fiber membrane 200, i.e., the weft direction. Therefore, this arrangement further facilitates the weaving of the hollow fiber membrane woven mat provided by the present invention, and also further improves the overall strength of the hollow fiber membrane woven mat provided by the present invention.

[0051] Furthermore, in one embodiment, such as Figure 1As shown, the hollow fiber membrane woven mat also includes multiple third hollow fiber membranes 300. A third hollow fiber membrane 300 is disposed between any two adjacent first hollow fiber membranes 100. The length direction of the third hollow fiber membrane 300 is parallel to the length direction of the first hollow fiber membrane 100. The third hollow fiber membrane 300 intersects with the second hollow fiber membranes 200, thereby forming multiple second intersection points 428. Furthermore, the multiple second hollow fiber membranes 200 are arranged sequentially along the length direction of the third hollow fiber membrane 300, alternating between inside and outside. "Inside and outside" refers to the paper surface or the observer; as mentioned earlier, the area closer to the observer is outside, and the area farther from the observer is inside. At each of the second intersections 428, the alternating inner and outer sequences formed by the plurality of second hollow fiber membranes 200 along the length direction of the third hollow fiber membrane 300 are opposite to the alternating inner and outer sequences formed along the length direction of the first hollow fiber membrane 100, so that the second hollow fiber membrane 200 and the plurality of third hollow fiber membranes 300 form a plurality of alternating second outward protrusions 420 and second inward protrusions 425 at the second intersections 428 in the length direction.

[0052] Therefore, with Figure 1 From the observer's perspective, for each of the second hollow fiber membranes 200, at the first intersection 408 with the first hollow fiber membrane 100, if the second hollow fiber membrane 200 presses against the first hollow fiber membrane 100, then the second hollow fiber membrane 200 forms a first outward convex portion 410; if the second hollow fiber membrane 200 is pressed against the first hollow fiber membrane 100, then the second hollow fiber membrane 200 forms a first inward convex portion 405. Simultaneously, for each of the second hollow fiber membranes 200, at the second intersection 428 with the third hollow fiber membrane 300, if the second hollow fiber membrane 200 presses against the third hollow fiber membrane 300, then the second hollow fiber membrane 200 forms a second outward convex portion 420; if the second hollow fiber membrane 200 is pressed against the third hollow fiber membrane 300, then the second hollow fiber membrane 200 forms a second inward convex portion 425.

[0053] Therefore, by setting multiple third hollow fiber membranes 300, the overall strength of the hollow fiber membrane woven pad provided by the present invention can be effectively improved, thereby extending the service life of the hollow fiber membrane module made using the hollow fiber membrane woven pad provided by the present invention. Furthermore, since the alternating sequence of the multiple second hollow fiber membranes 200 arranged sequentially along the length direction of the third hollow fiber membrane 300 is the opposite of the alternating sequence of the multiple second hollow fiber membranes 200 arranged sequentially along the length direction of the first hollow fiber membrane 100, that is, the alternating sequence of the second outward protrusion 420 and the second inward protrusion 425 is the opposite of the alternating sequence of the first inward protrusion 405 and the first outward protrusion 410, it can be ensured that the hollow fiber membrane woven pad provided by the present invention has multiple alternating inward and outward protrusions in both the warp and weft directions. This further ensures that the hollow fiber membranes in the hollow fiber membrane assembly made by the hollow fiber membrane woven pad provided by the present invention will not overlap, that is, it can ensure that the hollow fiber membranes in the hollow fiber membrane assembly made by the hollow fiber membrane woven pad provided by the present invention can form an effective flow channel, further preventing the hollow fiber membrane assembly made by the hollow fiber membrane woven pad provided by the present invention from clogging during use.

[0054] It should be noted that, as those skilled in the art will understand, when the orientation of the woven mat is fixed, the second outward protrusion 420 formed by the second hollow fiber membrane 200 on the third hollow fiber membrane 300 is the intersection of the second hollow fiber membrane 200 and the third hollow fiber membrane 300; at this intersection point, the third hollow fiber membrane 300 is away from the observer, while the second hollow fiber membrane 200 is close to the observer, such that the third hollow fiber membrane 300 is located below the woven mat at this intersection point.

[0055] When the orientation of the woven pad is fixed, the second hollow fiber membrane 200 forms a second inner protrusion 425 on the third hollow fiber membrane 300, which is the intersection of the second hollow fiber membrane 200 and the third hollow fiber membrane 300; at this intersection point, the third hollow fiber membrane 300 is closer to the observer, while the second hollow fiber membrane 200 is farther away from the observer, so that the second hollow fiber membrane 200 is located below the woven pad at this intersection point.

[0056] Furthermore, it should be noted that, as those skilled in the art will understand, for a specific woven mat, starting from the leftmost side, when the multiple second hollow fiber membranes 200 are arranged alternately along the length direction of the first hollow fiber membrane 100 in the order of inside-outside-inside-outside-inside... (that is, the first inner convex portion 405 and the first outer convex portion 410 are arranged in the order of first inner convex portion 405, first outer convex portion 410, first inner convex portion 405, first outer convex portion 410, first inner convex portion 405, first outer convex portion 410, first inner convex portion 405), When the first outward protrusions 410... are arranged alternately, the multiple second hollow fiber membranes 200 are arranged alternately along the length direction of the third hollow fiber membrane 300 in the order of outward-inward-inward-inward-inward... (that is, the second outward protrusions 420 and the second inward protrusions 425 are arranged alternately in the order of second outward protrusion 420, second inward protrusion 425, second outward protrusion 420, second inward protrusion 425, second outward protrusion 420, second inward protrusion 425...). Furthermore, for this woven mat, the intersection points of all the second hollow fiber membranes 200 with each first hollow fiber membrane 100 are in the order of inward-inward-inward-inward-inward..., and the intersection points of all the second hollow fiber membranes 200 with each third hollow fiber membrane 300 are in the order of outward-inward-inward-inward-inward... That is, the alternation sequence of all the second hollow fiber membranes 200 and each of the first hollow fiber membranes 100 on the woven mat is the same, and the alternation sequence of all the second hollow fiber membranes 200 and each of the third hollow fiber membranes 300 is also the same. In other words, for any given second hollow fiber membrane 200, the arrangement at its first intersection with each of the first hollow fiber membranes 100 is the same; for the same second hollow fiber membrane 200, the arrangement at its second intersection with each of the third hollow fiber membranes 300 is also the same, but the alternation sequence of the second hollow fiber membranes 200 at the first and second intersections is reversed.

[0057] Similarly, for other woven mats, starting from the leftmost side, when the multiple second hollow fiber membranes 200 are arranged alternately along the length direction of the first hollow fiber membrane 100 in the order of outside inside inside inside inside inside… (that is, when the first inner convex portion 405 and the first outer convex portion 410 are arranged alternately in the order of first outer convex portion 410, first inner convex portion 405, first outer convex portion 410, first inner convex portion 405, first outer convex portion 410, first inner convex portion 405), then the multiple second hollow fiber membranes 200 are arranged alternately along the length direction of the third hollow fiber membrane 300 in the order of inside inside inside inside inside inside… (that is, when the second outer convex portion 420 and the second inner convex portion 425 are arranged alternately in the order of second inner convex portion 425, second outer convex portion 420, second inner convex portion 425, second outer convex portion 420, second inner convex portion 425, second outer convex portion 420…). Therefore, for this woven mat, the alternation sequence of all the second hollow fiber membranes 200 and each of the first hollow fiber membranes 100 is the same, and the alternation sequence of all the second hollow fiber membranes 200 and each of the third hollow fiber membranes 300 is also the same.

[0058] Please continue to refer to this. Figure 1 ,like Figure 1 As shown, a gap, namely a third gap, is provided between the third hollow fiber membrane 300 and the adjacent first hollow fiber membrane 100. The width of the third gap is greater than 0 and smaller than the width of the first gap. This ensures that a suitable gap can be formed between the adjacent first hollow fiber membrane 100 and the third hollow fiber membrane 300, allowing the medium to pass through the gap. This effectively prevents clogging of the hollow fiber membrane assembly made of the hollow fiber membrane woven pad provided by the present invention during use, thereby ensuring smooth flow in the internal channels of the first hollow fiber membrane 100 and the second hollow fiber membrane 200.

[0059] Preferably, such as Figure 1 As shown, the multiple third hollow fiber membranes 300 are arranged at equal intervals. This arrangement further ensures that after the hollow fiber membrane woven pad provided by this invention is wound into a bundle, a uniform hollow fiber membrane bundle can be obtained, thereby allowing the fluid to pass through the flow channel uniformly, effectively improving the utilization rate of the hollow fiber membrane and extending the service life of the hollow fiber membrane assembly made using the hollow fiber membrane woven pad provided by this invention.

[0060] Furthermore, in this embodiment, the distance between any two adjacent first hollow fiber membranes 100 and third hollow fiber membranes 300 (i.e., the width of the third gap between adjacent first hollow fiber membranes 100 and third hollow fiber membranes 300) is 1mm to 15mm, and the distance between any two adjacent second hollow fiber membranes 200 (i.e., the width of the second gap between adjacent second hollow fiber membranes 200) is 1mm to 15mm. Therefore, this arrangement ensures both the overall strength of the hollow fiber membrane woven pad provided by the present invention, preventing deformation of the hollow fiber membrane assembly made using the hollow fiber membrane woven pad provided by the present invention during use, and also ensures that suitable gaps can be formed between adjacent second hollow fiber membranes 200 and between adjacent first hollow fiber membranes 100 and third hollow fiber membranes 300, allowing the medium to pass through the gaps and effectively preventing blockage of the hollow fiber membrane assembly made using the hollow fiber membrane woven pad provided by the present invention during use.

[0061] In one exemplary embodiment, at least one of the first hollow fiber membrane 100, the second hollow fiber membrane 200, and the third hollow fiber membrane 300 has an outer diameter of 300 μm to 2000 μm, and at least one of the first hollow fiber membrane, the second hollow fiber membrane, and the third hollow fiber membrane has a thickness of 80 μm to 100 μm. Preferably, the outer diameter of the first hollow fiber membrane 100, the second hollow fiber membrane 200, and the third hollow fiber membrane 300 is 300 μm to 2000 μm, and the thickness of the first hollow fiber membrane 100, the second hollow fiber membrane 200, and the third hollow fiber membrane 300 is 80 μm to 100 μm. Therefore, this size setting can ensure the strength of a single first hollow fiber membrane 100, a single second hollow fiber membrane 200, and a single third hollow fiber membrane 300, thereby extending the service life of the first hollow fiber membrane 100, the second hollow fiber membrane 200, and the third hollow fiber membrane 300.

[0062] Preferably, the first hollow fiber membrane 100, the second hollow fiber membrane 200 and the third hollow fiber membrane 300 are all made of one or more of the following materials: polypropylene, polyethylene, polytetramethylisoprene, polyethersulfone, polysulfone, polyester, polytetrafluoroethylene and polyvinylidene fluoride.

[0063] Please continue to refer to this. Figure 2 The diagram illustrates a partial structural schematic of a hollow fiber membrane woven mat 20 provided in another embodiment of the present invention. Figure 2As shown, the difference between this embodiment and the previous embodiment is that in this embodiment, the first hollow fiber membrane 100 and the second hollow fiber membrane 200 are arranged in a cross configuration, and the cross angle is not equal to 90°, thereby forming a first cross point 408. Therefore, by setting the first hollow fiber membrane 100 and the second hollow fiber membrane 200 to be obliquely cross, it can be further ensured that the hollow fiber membrane layers in the hollow fiber membrane assembly made of the hollow fiber membrane woven pad provided by the present invention will not overlap, thereby ensuring that an effective flow channel can be formed between the hollow fiber membrane layers in the hollow fiber membrane assembly made of the hollow fiber membrane woven pad provided by the present invention, further preventing clogging of the hollow fiber membrane assembly made of the hollow fiber membrane woven pad provided by the present invention during use. It should be noted that, as those skilled in the art will understand, in this embodiment, the cross angle of the first hollow fiber membrane 100 and the second hollow fiber membrane 200 can be set according to actual conditions, and the present invention does not limit this; for example, it can be 30°, 45°, or 60°.

[0064] Furthermore, such as Figure 2 As shown, the difference between this embodiment and the previous embodiment is that in this embodiment, multiple third hollow fiber membranes 300 are arranged parallel to each other and spaced apart along the length direction of the second hollow fiber membrane 200, and intersect with the second hollow fiber membrane 200 at an angle equal to or not equal to 90°, thereby forming a second intersection point 428. The multiple third fiber membranes 300 are alternately arranged inside and outside along the length direction of the first hollow fiber membrane 100, and the second intersection point 428 coincides with the first intersection point 408.

[0065] Furthermore, the third hollow fiber membrane 300 and the first hollow fiber membrane 100 are neither parallel nor overlapping; in other words, the third hollow fiber membrane 300 and the first hollow fiber membrane 100 are also intersecting, thus forming a situation where the third intersection point coincides with the second intersection point 428 and the first intersection point 408. Therefore, in this embodiment, the first hollow fiber membrane 100, the second hollow fiber membrane 200, and the third hollow fiber membrane 300 intersect at each intersection point using three lines. This results in a greater total thickness at each intersection point compared to the thickness in the first embodiment, thereby further ensuring that the hollow fiber membrane layers in the hollow fiber membrane assembly made using the hollow fiber membrane woven pad provided by this invention do not overlap. This also ensures that an effective flow channel can be formed between the hollow fiber membrane layers in the hollow fiber membrane assembly made using the hollow fiber membrane woven pad provided by this invention, further preventing blockage during use.

[0066] like Figure 2 As shown, preferably, the intersection angle between the third hollow fiber membrane 300 and the second hollow fiber membrane 200 is 90°. This angle setting facilitates the weaving of the hollow fiber membrane woven mat provided by the present invention. It should be noted that, as those skilled in the art will understand, in some other embodiments, the intersection angle between the third hollow fiber membrane 300 and the second hollow fiber membrane 200 can be other angles, which can be set according to the actual situation.

[0067] Furthermore, in addition to, Figure 1 and Figure 2 In the example, for any given hollow fiber membrane, when it forms multiple intersections with any other hollow fiber membranes arranged in parallel, the intersections are all spaced vertically. In other words, looking along the length of any hollow fiber membrane, the multiple intersections formed on the hollow fiber membrane cause it to exhibit an alternating sequence of inward and outward convexity. It can be understood that the meanings of outward and inward convexity here are consistent with those mentioned earlier.

[0068] by Figure 2 Taking the first hollow fiber membrane 100 as an example, the first hollow fiber membrane 100 and multiple parallel second hollow fiber membranes 200 form multiple intersection points. The first hollow fiber membranes 100 intersect in an alternating manner; that is, looking along the length of any hollow fiber membrane 100, the multiple intersection points formed on the hollow fiber membrane 100 cause the hollow fiber membrane 100 to be arranged alternately in the order of outward convexity, inward convexity, outward convexity, inward convexity, i.e., alternating arrangement of inside and outside.

[0069] It should be noted that, in Figure 2 In the specific example, since the intersection is formed by three hollow fiber membranes, the terms "outer convexity" and "inner convexity" do not refer to the outermost position among the three hollow fiber membranes. Rather, they refer to the overall trend of the first hollow fiber membrane 100, showing its outward and inward convex variations. As for the intersection, there is no restriction on whether the outermost position is the first hollow fiber membrane 100, the second hollow fiber membrane 200, or the third hollow fiber membrane 300 among the three hollow fiber membranes; it can be set according to the specific needs of each intersection.

[0070] For example, in such Figure 2 In the specific example, the first hollow fiber membrane 100 at each intersection is the outermost layer, while the outermost layer on the opposite side of the first hollow fiber membrane 100 at the intersection is either the second hollow fiber membrane 200 or the third hollow fiber membrane 300.

[0071] Therefore, this design can further ensure the overall strength of the hollow fiber membrane woven mat provided by the present invention.

[0072] Furthermore, in this embodiment, the distance between any two adjacent first hollow fiber membranes 100 is 1mm to 15mm. This arrangement ensures the overall strength of the hollow fiber membrane woven pad provided by the present invention, preventing deformation of the hollow fiber membrane assembly made using the hollow fiber membrane woven pad provided by the present invention during use. It also ensures that suitable gaps can be formed between adjacent first hollow fiber membranes 100, adjacent second hollow fiber membranes 200, and adjacent third hollow fiber membranes 300, allowing the medium to pass through the gaps and effectively preventing blockage of the hollow fiber membrane assembly made using the hollow fiber membrane woven pad provided by the present invention during use.

[0073] To achieve the above-mentioned goals, this invention also provides a hollow fiber membrane module, which includes the hollow fiber membrane braided pad described above. Therefore, the hollow fiber membrane module provided by this invention can effectively reduce the damage to the hollow fiber membrane caused by traditional processes, effectively reducing the risk of plasma leakage. Furthermore, since the hollow fiber membrane module provided by this invention does not require the use of braided yarn, it can reduce the impact of other introduced materials on the compatibility with human blood, effectively avoid the risk of thrombosis caused by the braided yarn locking the hollow fiber membrane, effectively prevent scratches on the surface of the hollow fiber membrane, and effectively increase the packing density of the hollow fiber membrane, thereby increasing the blood oxygen exchange capacity, reducing the blood prefilling volume, and reducing the risk of blood exposure. It should be noted that, as those skilled in the art will understand, the hollow fiber membrane module provided by this invention also has other advantages of the hollow fiber membrane braided pad described above, which can be referred to in the relevant content above, and will not be elaborated further here.

[0074] Specifically, the hollow fiber membrane woven mat provided by this invention can be wound, laid flat, stacked, or otherwise encapsulated to produce the hollow fiber membrane assembly provided by this invention. For example, the hollow fiber membrane woven mat provided by this invention can be directly wound into a bundle to form a hollow fiber membrane bundle, and then the two ends of the hollow fiber membrane bundle can be encapsulated with glue to produce an oxygenator.

[0075] In summary, compared with the prior art, the hollow fiber membrane woven mat and hollow fiber membrane module provided by the present invention have the following advantages:

[0076] The hollow fiber membrane woven mat provided by this invention prevents overlap between the layers of hollow fiber membranes in hollow fiber membrane modules prepared by winding or other methods. This allows for direct winding of the hollow fiber membrane woven mat into bundles to form hollow fiber membrane modules. Compared to existing technologies that require single-layer hollow fiber membrane mats formed from warp-knitted hollow fiber membranes and braided yarns to be angled and bent, then rewound twice to form double-layer mats, and finally wound into hollow fiber membrane modules, the hollow fiber membrane woven mat provided by this invention can be directly formed in one step. This effectively reduces damage to the hollow fiber membrane caused by traditional processes and significantly lowers the risk of plasma leakage. Furthermore, since the hollow fiber membrane braided pad provided by this invention does not require the use of braided yarn, it can reduce the impact of other introduced materials on the compatibility of human blood, effectively avoid the risk of thrombosis caused by the braided thread locking the hollow fiber membrane, effectively prevent scratches on the surface of the hollow fiber membrane, and also effectively increase the packing density of the hollow fiber membrane, thereby increasing the blood oxygen exchange capacity, reducing the blood prefilling volume, and reducing the risk of blood exposure.

[0077] Since the hollow fiber membrane module provided by the present invention includes the hollow fiber membrane woven pad described above, the hollow fiber membrane module provided by the present invention has all the advantages of the hollow fiber membrane woven pad described above. Therefore, the beneficial effects of the hollow fiber membrane module provided by the present invention will not be described in detail here.

[0078] Another embodiment of the present invention also provides an oxygenator. For example... Figure 3 As shown, the oxygenator 50 includes a housing 51, an encapsulation part 52, and the aforementioned hollow fiber membrane woven pad. The aforementioned hollow fiber membrane woven pad can be... Figure 1 Hollow fiber membrane woven pad 10 or Figure 2 The hollow fiber membrane woven mat 20 can be formed by rolling hollow fiber membrane woven mats together or by laying multiple hollow fiber membrane woven mats flat.

[0079] The housing 51 includes an air inlet chamber 510 located at one end of the housing 51, an air outlet chamber 520 located at the other end of the housing 51, and an exchange chamber 530 located between the air inlet chamber 510 and the air outlet chamber 520.

[0080] It is understandable that the air intake chamber 51 is provided with an air intake port 501. The air outlet chamber 520 is provided with an air outlet 502.

[0081] The exchange chamber 530 is equipped with a blood inlet 503 and a blood outlet 504. A hollow fiber membrane woven pad is placed inside the exchange chamber 530.

[0082] The two ends of the hollow fiber membrane woven pad are sealed to the inner wall of the exchange chamber 530 by the encapsulation part 52, so that the inlet chamber 510 and the outlet chamber 520 are connected through the hollow hole structure of multiple first hollow fiber membranes 100 and / or multiple second hollow fiber membranes 200 of the hollow fiber membrane woven pad 10. In other words, through the sealing of the encapsulation part 52, the inlet chamber 510 and the outlet chamber 520 are independent of the exchange chamber 530, so that the gas in the inlet chamber 510 and the outlet chamber 520 does not directly contact the blood in the exchange chamber 530. The gas in the inlet chamber 510 and the outlet chamber 520 indirectly exchanges with the blood in the exchange chamber 530 through the hollow hole structure of the fiber membrane in the hollow fiber membrane woven pad.

[0083] Specifically, when the intake chamber 510 and the exhaust chamber 520 are connected through the hollow hole structure of multiple first hollow fiber membranes 100 of the hollow fiber membrane woven pad 10, and the two ends of the hollow fiber membrane woven pad are sealed to the inner wall of the exchange chamber 530 through the sealing part 52, the gaps between the multiple first hollow fiber membranes 100 and the inner wall of the exchange chamber 530 can be sealed by the sealing part 52, and the second hollow fiber membrane 200 can also participate in the sealing. It can be understood that the situation is similar when the intake chamber 510 and the exhaust chamber 520 are connected through the hollow hole structure of multiple second hollow fiber membranes 200 of the hollow fiber membrane woven pad 10.

[0084] The two ends of multiple first hollow fiber membranes 100 and / or the two ends of multiple second hollow fiber membranes 200 are sealed to the inner wall of the exchange chamber 530 through the encapsulation part 52.

[0085] When the oxygenator 50 is working, oxygen can enter the intake chamber 510 from the intake port 501 and then enter the hollow pore structure of multiple first hollow fiber membranes 100 or multiple second hollow fiber membranes 200. Blood fills the gaps between the hollow fiber membranes of the hollow fiber membrane woven pad 10 in the exchange chamber 530 from the blood inlet 503, and exchanges with oxygen in the hollow pore structure of multiple first hollow fiber membranes 100 or multiple second hollow fiber membranes 200 in the exchange chamber 530. The exchanged gas is discharged from the exhaust chamber 520, and the exchanged blood flows out from the bleeding port 504.

[0086] Furthermore, the housing 51 may be a hollow cylinder, but is not limited to this. Furthermore, the housing 51 may be made of a transparent material, such as PC (polycarbonate). The hollow cylindrical housing 51 facilitates the placement of a wound hollow fiber membrane woven pad. The air inlet chamber 510, the exchange chamber 530, and the air outlet chamber 520 are sequentially arranged along the axial direction of the hollow cylindrical housing 51.

[0087] Optionally, the hollow fiber membrane woven pad is wound up and disposed within the exchange chamber 530. The hollow fiber membrane connecting the inlet chamber 510 and the outlet chamber 520 is composed of multiple first hollow fiber membranes 100 or multiple second hollow fiber membranes 200. If the axial direction of the hollow fiber membrane connecting the inlet chamber 510 and the outlet chamber 520 is taken as the first direction, then the axial direction of the wound hollow fiber membrane woven pad is the same as the first direction.

[0088] In other words, the axial direction of the hollow fiber membrane connecting the air inlet chamber 510 and the air outlet chamber 520 is the same as the axial direction of the housing 51.

[0089] For example Figure 1 Hollow fiber membrane woven pad 10 or Figure 2 When the hollow fiber membrane woven pad 20 is placed in the exchange chamber 530, and the hollow fiber membrane connecting the air inlet chamber 510 and the air outlet chamber 520 is a plurality of second hollow fiber membranes 200, then the axial direction of the wound hollow fiber membrane woven pad is the axial direction of the plurality of second hollow fiber membranes 200.

[0090] In some embodiments, the exhaust chamber 520 is also provided with a communication port (not shown) communicating with the atmosphere.

[0091] Specifically, in such Figure 3 In the specific example shown, the encapsulation part 52 can be an adhesive encapsulation part; specifically, by bonding the two ends of the wound hollow fiber membrane braided pad to the inner wall of the housing 51 with adhesive, the sealing between the two ends of the hollow fiber membrane braided pad and the sealing between the two ends of the hollow fiber membrane braided pad and the interior of the housing 51 are achieved, thereby making the air inlet chamber 510 and the air outlet chamber 520 independent of the exchange chamber 530.

[0092] Understandably, in other examples, hollow fiber membrane woven mats may also be laid flat within the exchange chamber. Accordingly, the structure of the housing may be configured to resemble the shape of the laid-flat hollow fiber membrane woven mat. Understandably, one or more hollow fiber membrane woven mats may be placed inside the housing, and multiple hollow fiber membrane woven mats may be stacked.

[0093] Please see Figure 4 , its and like Figure 3 The difference is that the hollow fiber membrane woven pad 10 is laid flat inside the exchange chamber 530, and the connection between the hollow fiber membrane and the inlet chamber 510 and the outlet chamber 520 is also different. Furthermore, the structure of the housing 51 and the encapsulation part 52 are also different.

[0094] The first hollow fiber membrane 100 includes a first end 101 and a second end 102 opposite to each other, and the second hollow fiber membrane 200 includes a third end 201 and a fourth end 202 opposite to each other. In one embodiment, the first end 101 is located on a first side (left side in the figure), the second end 102 is located on a second side opposite to the first side (right side in the figure); the third end 201 is located on a third side (upper side in the figure), and the fourth end 202 is located on a fourth side opposite to the third side (lower side in the figure). The first end 101 of each first hollow fiber membrane 100 and the third end 201 of each second hollow fiber membrane 200 are connected to the air inlet chamber 510, and the second end 102 of each first hollow fiber membrane 100 and the fourth end 202 of each second hollow fiber membrane 200 are connected to the air outlet chamber 520. This allows for full utilization of each hollow fiber membrane and improves blood oxygen exchange capacity.

[0095] Specifically, the housing 51 has a square structure. The exchange chamber 530 is located in the middle of the square housing 51, and the inlet chamber 510 and outlet chamber 520 are arranged around the exchange chamber 530. The hollow fiber membrane woven pad 10 is laid flat inside the exchange chamber 530, and the encapsulation part 52 divides the inlet chamber 510, outlet chamber 52 and exchange chamber 530 into two independent pairs.

[0096] Furthermore, the encapsulation section 52 can employ a combination of partitions and adhesive to ensure that both the inlet chamber 510 and the outlet chamber 520 are independent of the exchange chamber 530. Specifically, the ends of each hollow fiber membrane are bonded to the inner wall of the housing 51 with adhesive to form an adhesive encapsulation section 521, achieving a seal between the hollow fiber membranes at each end and a seal between the membranes and the interior of the housing 51, thereby making the exchange chamber 530 independent of other areas within the housing. A first partition 522 and a second partition 523 are provided in the area between the inner wall of the housing and the exchange chamber 530 to form independent inlet chambers 510 and outlet chambers 520, ensuring that the first end 101 of each first hollow fiber membrane 100 and the third end 201 of each second hollow fiber membrane 200 are connected to the inlet chamber 510, and the second end 201 and the fourth end 202 of each first hollow fiber membrane 100 are connected to the outlet chamber 520. It is understood that when in such... Figure 4 The oxygenator shown uses an exchange chamber 530 as described above. Figure 2 When the hollow fiber membrane woven mat 20 is shown, it can also be laid flat on such a surface. Figure 4 The structure of the exchange chamber 530 shown is basically similar. In this case, in addition to the above-mentioned arrangement, one end of the third hollow fiber membrane 300 is connected to the air inlet chamber 510, and the other end is connected to the air outlet chamber 520.

[0097] Another embodiment of the present invention provides an artificial heart-lung machine, including the oxygenator described above. The artificial heart-lung machine can be used for extracorporeal circulation during cardiac surgery, assisted breathing during lung transplantation, and adjunctive treatment of acute respiratory failure. It is understood that the artificial heart-lung machine may also include a blood pump, which is connected to the blood inlet of the oxygenator.

[0098] The following are performance tests.

[0099] Example 1: Using as follows Figure 3 The oxygenator shown contains a hollow fiber membrane woven pad, such as... Figure 1 As shown.

[0100] Example 2: Using as follows Figure 3 The oxygenator shown contains a hollow fiber membrane woven pad, such as... Figure 2 As shown.

[0101] Comparative Example 1: Using as... Figure 3 The oxygenator shown contains a hollow fiber membrane woven pad. This single-layer hollow fiber membrane pad, formed from a hollow fiber membrane and woven yarn, must undergo oblique angle shaping to create a bending angle, followed by two rewinding processes to form a double-layer membrane pad cross-product. Finally, it is wound into a hollow fiber membrane. For specific preparation methods, please refer to Chinese patent application CN11665121A. Figure 4 The hollow fiber membrane pad shown.

[0102] The steps for testing the blood oxygen exchange capacity of the oxygenators of Examples 1-2 and Comparative Example 1 are as follows:

[0103] 1) Venous blood test. Venous blood was tested according to YY 0604-2016. After pre-rinsing and defoaming, blood was introduced through the inlet at a set blood flow rate of 3 L / min. Gas mixing was turned on, and a mixture of 5% CO2 and 95% N2 (volume ratio 1:1) was introduced into the oxygenator through the inlet 501 of the inlet chamber 510 at a blood-to-gas volume ratio of 1:1. The gas flow rate was set to 3 L / min, and the venous blood exchange time was 5 minutes.

[0104] 2) Arterial blood test. After the venous blood test is completed, 100% O2 is introduced into the air inlet 501 at a gas-to-blood volume ratio of 1:1. After stabilization, the blood gas value at the blood outlet 504 is tested.

[0105] Table 1

[0106]

[0107]

[0108] In Table 1: the filling area refers to the total outer surface area of ​​each hollow fiber in the hollow fiber membrane woven pad in the oxygenator.

[0109] PCO2 refers to the partial pressure of CO2, tHB refers to total hemoglobin, SO2 refers to oxygen saturation, and PO2 refers to the partial pressure of O2. Total carbon dioxide refers to the total concentration of carbon dioxide in the blood (including bicarbonate, carbon dioxide, and carbonate).

[0110] The formula for calculating the amount of O2 bound is ΔO2=CaO2-CvO2, where: CaO2 refers to the O2 content in the blood at the bleeding point (oxygen content mL / blood volume L), which includes O2 bound to hemoglobin and dissolved in plasma; CvO2 refers to the O2 content in the blood at the blood inlet (oxygen content mL / blood volume L), which includes O2 bound to hemoglobin and dissolved in plasma.

[0111] The formula for calculating the O2 conversion rate is T(O2)=Q*(CaO2-CvO2), where: T(O2) refers to the oxygen conversion rate; Q refers to the blood flow rate in L / min; and CaO2 and CvO2 have the same meaning as above.

[0112] The formula for calculating CO2 emissions is ΔCO2=(tCvCO2-tCaCO2)*22.4L / mol, where: tCaCO2 refers to the CO2 content in the blood at the bleeding point (mLCO2 / L blood), and tCvCO2 refers to the CO2 content in the blood at the blood inlet (mLCO2 / L blood).

[0113] The formula for calculating CO2 conversion rate is T(CO2)=Q*(tCvCO2-tCaCO2)*22.4L / mol, where: Q refers to blood flow rate in L / min, and tCaCO2 and tCvCO2 are defined as above.

[0114] Therefore, based on the same external structure and volume of the oxygenator, compared with Comparative Example 1, the hollow fiber membrane braided pad of the present invention has a larger filling area, which means a higher filling density (i.e., more hollow fiber membranes are accommodated in the same volume of the hollow fiber membrane braided pad), resulting in a higher partial pressure of oxygen in arterial blood, indicating excellent blood oxygenation performance. The hollow fiber membrane braided pad of the present invention has a greater O2 binding capacity, thus resulting in higher O2 conversion rate, CO2 emission rate, and CO2 conversion efficiency.

[0115] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0116] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this invention patent should be determined by the appended claims.

Claims

1. A hollow fiber membrane woven mat, characterized in that, The device includes multiple first hollow fiber membranes and multiple second hollow fiber membranes. The multiple first hollow fiber membranes are arranged parallel to each other and spaced apart, thereby forming multiple first gaps. The multiple second hollow fiber membranes are arranged parallel to each other and spaced apart, thereby forming multiple second gaps. The first hollow fiber membranes and the second hollow fiber membranes are arranged intersectingly, thereby forming multiple first intersection points. The multiple second hollow fiber membranes are arranged sequentially along the length direction of the first hollow fiber membranes, alternating between inside and outside, so that the multiple second hollow fiber membranes form multiple alternating first inner protrusions and first outer protrusions at each first intersection point along the length direction of the first hollow fiber membranes. The width of the first gap between any two adjacent first hollow fiber membranes is 1mm to 15mm.

2. The hollow fiber membrane woven mat according to claim 1, characterized in that, The width of at least one of the plurality of first gaps is greater than or equal to the width of at least one of the plurality of first hollow fiber membranes; the width of at least one of the plurality of second gaps is greater than or equal to the width of the second hollow fiber membrane; And / or, The width of the first gap between any two adjacent first hollow fiber membranes is equal, and the width of the second gap between any two adjacent second hollow fiber membranes is equal.

3. The hollow fiber membrane woven mat according to claim 1, characterized in that, The intersection angle between the first hollow fiber membrane and the second hollow fiber membrane is equal to 90°. The hollow fiber membrane woven pad also includes multiple third hollow fiber membranes. One third hollow fiber membrane is provided between any two adjacent first hollow fiber membranes. The length direction of the third hollow fiber membrane is parallel to the length direction of the first hollow fiber membrane. A third gap is formed between the third hollow fiber membrane and the adjacent first hollow fiber membrane. The width of the third gap is greater than 0 and less than the width of the first gap. The third hollow fiber membrane and the second hollow fiber membrane are intersected to form multiple second intersection points. The multiple second hollow fiber membranes are arranged sequentially along the length direction of the third hollow fiber membrane, alternating between inside and outside. At each second intersection point, the alternating sequence of inside and outside formed by the multiple second hollow fiber membranes along the length direction of the third hollow fiber membrane is opposite to the alternating sequence of inside and outside formed along the length direction of the first hollow fiber membrane, so that the second hollow fiber membrane forms multiple alternating second outward protrusions and second inward protrusions at each second intersection point.

4. The hollow fiber membrane woven mat according to claim 3, characterized in that, For any second hollow fiber membrane, the alternation sequence of its inner and outer parts at the first intersection point is the same as that of each first hollow fiber membrane, and the alternation sequence of its inner and outer parts at the second intersection point is the same as that of each third hollow fiber membrane, but the alternation sequence of the inner and outer parts of the second hollow fiber membrane at the first intersection point and the second intersection point is reversed.

5. The hollow fiber membrane woven mat according to claim 3, characterized in that, The width of the third gap between any two adjacent first hollow fiber membranes and the third hollow fiber membrane is 1mm to 15mm, and the width of the second gap between any two adjacent second hollow fiber membranes is 1mm to 15mm.

6. The hollow fiber membrane woven mat according to claim 1, characterized in that, The intersection angle between the first hollow fiber membrane and the second hollow fiber membrane is not equal to 90°; the hollow fiber membrane woven pad also includes multiple third hollow fiber membranes, which are parallel to each other and spaced apart along the length direction of the second hollow fiber membrane, and intersect with the second hollow fiber membrane at an angle equal to or not equal to 90°. The multiple third fiber membranes are alternately arranged inside and outside along the length direction of the first hollow fiber membrane, and the third hollow fiber membranes intersect with the second hollow fiber membrane, thereby forming multiple second intersection points. The first intersection point coincides with the second intersection point.

7. The hollow fiber membrane woven mat according to claim 6, characterized in that, Along the length of any hollow fiber membrane, multiple intersections formed on the hollow fiber membrane cause the hollow fiber membrane to be arranged in an alternating inner and outer sequence.

8. The hollow fiber membrane woven mat according to claim 3 or 6, characterized in that, The outer diameter of at least one of the first hollow fiber membrane, the second hollow fiber membrane, and the third hollow fiber membrane is 300 μm to 2000 μm, and the thickness of at least one of the first hollow fiber membrane, the second hollow fiber membrane, and the third hollow fiber membrane is 80 μm to 100 μm.

9. An oxygenator, characterized in that, include: The housing includes an air inlet chamber at one end, an air outlet chamber at the other end, and an exchange chamber between the air inlet chamber and the air outlet chamber, the exchange chamber being provided with a blood inlet and a blood outlet; The hollow fiber membrane woven mat as described in any one of claims 1 to 8, wherein the hollow fiber membrane woven mat is disposed in the exchange chamber; and The encapsulation section seals both ends of the hollow fiber membrane woven pad with the inner wall of the exchange chamber through the encapsulation section, so that the air inlet chamber and the air outlet chamber are connected through the hollow hole structure of the multiple first hollow fiber membranes and / or the multiple second hollow fiber membranes.

10. The oxygenator according to claim 9, characterized in that, The hollow fiber membrane woven pad is wound and disposed in the exchange chamber. The axial direction of the plurality of first hollow fiber membranes or the plurality of second hollow fiber membranes connected to the encapsulation part is a first direction, and the axial direction of the wound hollow fiber membrane woven pad is the same as the first direction; or, The hollow fiber membrane woven pad is laid flat in the exchange chamber. The first hollow fiber membrane includes a first end and a second end opposite to each other, and the second hollow fiber membrane includes a third end and a fourth end opposite to each other. The first end of each first hollow fiber membrane and the third end of each second hollow fiber membrane are connected to the air inlet chamber, and the second end of each first hollow fiber membrane and the fourth end of each second hollow fiber membrane are connected to the air outlet chamber.

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