An array-type electrode independent control device and control method

Abstract

The application discloses an array electrode group electrode independent control device and a control method, relates to the technical field of electronic medical treatment, and comprises a radio frequency generating device, a radio frequency isolation voltage division module, an electrode independent control module, an array electrode group, a microcontroller, a control module, an input and display module; the radio frequency isolation voltage division module is used for isolating and dividing a radio frequency source into radio frequency ablation signals with the same frequency, the same phase and different voltage values through a high-frequency transformer; the array electrode group is used for transmitting radio frequency treatment signals and applying the radio frequency signals to solid tissues; the microcontroller is used for realizing a radio frequency treatment system and controlling the work of the array electrode group; and the control module is used for controlling the radio frequency voltage or power applied to the array electrode group in real time and the electrode work mode. The array electrode group electrode independent control device provided by the application is simple to operate, convenient to use, can accurately control irregularly shaped tissues to perform conformal ablation and accurate boundary temperature control, and has high practicability.

Description

Technical Field

[0001] This invention relates to the field of electronic medical technology, and in particular to an array-type electrode independent control device and control method. Background Technology

[0002] With the continuous advancement of technology, bio-tissue conformal therapy has become an important technology in the medical field. Its main goal is to maximize the treatment target at the lesion site while minimizing damage to healthy tissue. Currently, the main methods for bio-tissue conformal therapy include the following:

[0003] The first method is a thermal ablation technique based on the synergistic action of multiple electrodes / needles. This method typically achieves synergistic effects by controlling the on / off state of each individual electrode and the output voltage of the circuit. This approach allows for more comprehensive coverage of the lesion, improving treatment outcomes.

[0004] The second method is a thermal ablation technique based on multiple combinations of bipolar or monopolar electrodes / probes to cover and ablate the lesion. This method provides the optimal puncture path and treatment plan through preoperative surgical planning, and guides the treatment of the lesion to be ablated based on imaging methods. By combining multiple ablation methods to cover and ablate the lesion, precise and conformal treatment is achieved.

[0005] The third method is based on the characteristics of the ablation lesion site, designing expandable compliant electrodes such as umbrella needle electrodes. This method adjusts the shape of the working electrode based on the unfolded state of the compliant electrode to achieve conformal ablation of the target lesion site. It can better adapt to the shape and location of the lesion, achieving more precise treatment results.

[0006] However, when ablating irregularly shaped plaques that require rapid completion of the procedure, such as in the treatment of atherosclerotic plaques during angioplasty, blood flow needs to be blocked during the procedure, making it difficult to achieve the goal of precise conformal therapy.

[0007] Therefore, those skilled in the art are dedicated to developing an array-type electrode independent control device and control method. Summary of the Invention

[0008] In view of the above-mentioned deficiencies of the prior art, the technical problem to be solved by the present invention is that the prior art is difficult to achieve precise conformal ablation of radio frequency, and cannot simultaneously emit multiple independent radio frequency signals with the same frequency, the same phase, and different voltage values ​​during the control process.

[0009] To achieve the above objectives, the present invention provides an independent electrode control device for an array-type electrode group, comprising: a radio frequency (RF) generator, an RF isolation voltage divider module, an independent electrode control module, an array-type electrode group, a microcontroller, a control module, and an input and display module. The RF isolation voltage divider module is used to isolate and divide a single RF source into multiple sets of RF ablation signals with the same frequency and phase but different power and / or voltage through a high-frequency transformer. The array-type electrode group is used to transmit RF treatment signals and apply them to the target tissue. The microcontroller is used to implement the operation of the RF treatment system and control the operation of the electrode group.

[0010] Furthermore, the radiofrequency generating device includes a radiofrequency ablation signal source and a cold circulation system; the cold circulation system is used for cold protection during the operation of the array electrode group, to protect the electrode temperature from excessively high temperatures that could lead to carbonization; or to protect the epidermal cells in contact with the electrodes from damage during the process of radiofrequency penetration into tissue treatment; or to regulate the temperature during the treatment process.

[0011] Furthermore, the RF isolation voltage divider module includes a high-frequency transformer isolation circuit and a load matching circuit; the high-frequency transformer isolation circuit converts the input RF signal into multiple sets of RF ablation signals with the same frequency and phase, and the RF ablation signals are matched to the rated impedance of the RF ablation signal source by the load matching circuit to ensure that the RF output power and RF are not distorted.

[0012] Furthermore, the independent electrode control module includes multiple pluggable electrode control modules, each controlling one electrode. During treatment, the corresponding electrode module is inserted according to the actual number of electrodes used.

[0013] Furthermore, the electrode independent control module mainly includes a multi-line decoding circuit and a radio frequency electrode control circuit.

[0014] Furthermore, the control module is used to output the control scheme and control parameters of each electrode in real time and quickly according to the actual ablation situation using an array electrode control algorithm, and transmit them to the microcontroller. The microcontroller controls the working polarity and selected radio frequency voltage or power of each electrode.

[0015] Furthermore, the control module is an industrial control computer.

[0016] Furthermore, the input and display module adopts a touch screen design to display the radiofrequency ablation planning scheme, input the system's working parameters, select the working mode of the corresponding electrode, and display the ablation parameters in real time.

[0017] The present invention also provides a method for independent control of arrayed electrode groups, comprising the following steps:

[0018] S1: Obtain radiofrequency ablation information;

[0019] S2: Based on the specific ablation situation and the target area to be ablated, a radiofrequency treatment plan is derived;

[0020] S3: According to the planning scheme, select the corresponding radio frequency electrode n in the electrode array, select the applied cooling parameters including cooling temperature Tf and flow rate Vf, and take n+2 control parameters as decision variables;

[0021] S4: Based on optimization algorithms and data-driven algorithms, solve for the optimal decision variable values ​​of n+2 control parameters;

[0022] S5: Use the optimal decision variables obtained in S4 to control the output signals of each electrode, as well as the temperature Tf and flow rate Vf of the cold medium, and transmit the control parameters to the microcontroller 5 to control the output of the radiofrequency therapy module 1 and control the output radiofrequency voltage V1-Vn of the array radiofrequency electrode group.

[0023] S6: Real-time acquisition of temperature at corresponding locations in the target area, used as feedback input for the optimization algorithm, and real-time adjustment of the decision output variable values ​​of the optimization algorithm;

[0024] S7: Treatment ends when the planned treatment time is reached.

[0025] Furthermore, the optimization algorithm in step S4 can be selected from: genetic algorithm, particle swarm optimization algorithm, or simulated annealing algorithm.

[0026] Compared with existing technologies, the beneficial effects of this invention are as follows: The array-type electrode group electrode independent control device provided by this invention is simple to operate and convenient to use. During radiofrequency treatment, it enables independent control output of each electrode while allowing each electrode to independently select the voltage or power of the radiofrequency treatment signal. This allows multiple different radiofrequency signals to be output to the tissue simultaneously, achieving conformal ablation of the tissue. During radiofrequency treatment, it can precisely control irregularly shaped tissues for conformal ablation and precise temperature control at the boundaries, achieving thorough treatment while ensuring that beneficial tissues are not damaged, thus improving treatment efficiency and cure rate. In addition, this invention utilizes a non-dominated sorting genetic algorithm to calculate the working parameters of each electrode in real time, maximizing plaque ablation while minimizing thermal damage to non-plaque areas.

[0027] The following will further explain the concept, specific structure, and technical effects of the present invention in conjunction with the accompanying drawings, so as to fully understand the purpose, features, and effects of the present invention. Attached Figure Description

[0028] Figure 1 This is a schematic diagram of the structure of an array-type electrode group electrode independent control device according to a preferred embodiment of the present invention;

[0029] Figure 2 This is a flowchart of an array-type electrode group electrode independent control method according to a preferred embodiment of the present invention;

[0030] Figure 3 This is a diagram showing the effect of conformal ablation of atherosclerotic plaques using an array-type electrode independent control device and control method provided by the present invention.

[0031] In the diagram: 1. Radio frequency generator, 11. Radio frequency ablation signal source, 12. Cold cycle system, 2. Radio frequency isolation voltage divider module, 21. High frequency transformer isolation circuit, 22. Load matching circuit, 3. Electrode independent control module, 31. Multi-line decoding circuit, 32. Radio frequency electrode control circuit, 4. Array electrode group, 5. Microcontroller, 6. Control module, 7. Input and display module. Detailed Implementation

[0032] The following description, with reference to the accompanying drawings, illustrates several preferred embodiments of the present invention to make its technical content clearer and easier to understand. The present invention can be embodied in many different forms, and the scope of protection of the present invention is not limited to the embodiments mentioned herein.

[0033] In the accompanying drawings, components with the same structure are indicated by the same numerical designation, and components with similar structures or functions are indicated by similar numerical designations. The dimensions and thicknesses of each component shown in the drawings are arbitrary, and the present invention does not limit the dimensions and thicknesses of each component. To make the illustrations clearer, the thickness of some components has been appropriately exaggerated in the drawings.

[0034] like Figure 1 The diagram shown is a structural schematic of an array-type electrode group independent control device provided in this embodiment. The array-type electrode group independent control device provided in this embodiment includes: a radio frequency generator 1, a radio frequency isolation voltage divider module 2, an independent electrode control module 3, an array-type electrode group 4, a microcontroller 5, a control module 6, and an input and display module 7.

[0035] The input and display module 7 can be a touch screen. The input and display module 7 is used to display the radiofrequency treatment plan, input treatment parameters, select the working mode of the electrode and the applied radiofrequency voltage or power, and display real-time treatment parameters.

[0036] The control module 6 can be an industrial control computer, which serves as the carrier of the array electrode group electrode control method and control algorithm, controls the operation of the microcontroller 5, thereby quickly controlling the independent operation of the array electrode group 4, and at the same time receiving input information and driving the operation of the input and display module 7.

[0037] The microcontroller 5 is used to implement the operation of the radiofrequency therapy system and control the operation of the array electrode group 4.

[0038] The radio frequency isolation voltage divider module 2 is used to isolate and divide a radio frequency source into multiple independent radio frequency ablation signals with the same frequency, the same phase, and different voltage values ​​through a high-frequency transformer.

[0039] The array electrode group 4 is used to transmit radiofrequency treatment signals and apply them to the solid tissue. The control module 6 is used to control the radiofrequency voltage or power applied to the array electrode group 4 in real time, as well as the electrode operating mode.

[0040] In this embodiment, the radio frequency generation module 1 mainly includes a radio frequency ablation signal source 11 and a cold cycle system 12.

[0041] The cold circulation system 12 is used for cold protection during the operation of the array electrode group 4, to protect the electrode temperature from excessively high temperatures that could lead to carbonization, or to protect the epidermal cells in contact with the electrode from damage during radiofrequency penetration into the tissue for treatment, or to regulate the temperature during the treatment process.

[0042] In this embodiment, the radio frequency isolation voltage divider module 2 mainly includes a high-frequency transformer isolation circuit 21 and a load matching circuit 22.

[0043] In this embodiment, the high-frequency transformer isolation circuit 21 is used to convert the input radio frequency signal into multiple radio frequency signals with the same frequency and phase by designing the high-frequency transformer to output multiple sets of different transformation ratios. Then, each set of output radio frequency signals is matched to the rated impedance of the radio frequency ablation signal source by the load matching circuit 22, so as to ensure that the output power of the radio frequency and the radio frequency are not distorted.

[0044] In this embodiment, the array electrode control module 3 includes multiple pluggable electrode control modules, each of which can control the operation of one electrode. The radio frequency electrode control module mainly includes a multi-line decoding circuit 31 and a radio frequency electrode control circuit 32.

[0045] The microcontroller 5 uses I / O ports to control the input bits of the multi-line decoder, controls the output of the corresponding control bits of the decoder, and controls the RF electrode control circuit 32 to select the RF voltage or RF power corresponding to that bit to output to the RF electrode.

[0046] In this embodiment, the microcontroller 5 is mainly used to quickly and accurately control the power of the radiofrequency therapy module and control the operation of each pluggable radiofrequency electrode control module in the array electrode control module 3, thereby controlling the radiofrequency voltage applied to each electrode in the array radiofrequency electrode 4 and the working state of the electrode.

[0047] In this embodiment, the control module 6 serves as the carrier of the independent control method and control algorithm for the array electrode group. It is used to output the control scheme and control parameters of each electrode in real time and quickly according to the actual ablation situation, and transmit them to the microcontroller 5. The microcontroller 5 controls the working polarity and selected radio frequency voltage or power of each electrode.

[0048] In this embodiment, the input and display module 7 mainly adopts a touch screen design to display the radiofrequency ablation planning scheme, input the system's working parameters, select the working mode of the corresponding electrode, and display the ablation parameters in real time.

[0049] The array-type electrode group electrode independent control device provided in this embodiment is simple to operate and easy to use. During radiofrequency treatment, it can achieve independent control output of each electrode and independently select the voltage or power of the radiofrequency treatment signal for each electrode. This allows multiple different radiofrequency signals to be output to the tissue at the same time, achieving the purpose of conformal ablation of the tissue. During radiofrequency treatment, it can achieve thorough treatment while ensuring that beneficial tissues are not damaged, thus improving treatment efficiency and cure rate.

[0050] The workflow of the array-type electrode group independent control device is as follows: The input and display module 7 displays the radiofrequency ablation surgery plan, inputs the treatment parameters according to the actual treatment surgery, and transmits them to the control module 6. The control module 6 calculates the control method of the radiofrequency electrodes in real time according to the set treatment parameters using the array-type radiofrequency electrode control algorithm, and transmits it to the microcontroller 5. The microcontroller 5 controls the radiofrequency generation module 1 to output a radiofrequency ablation signal of a certain power according to the control command. The radiofrequency ablation signal is divided into multiple independent radiofrequency signals with different voltages, the same frequency, and the same phase by the radiofrequency isolation voltage divider module 2. At the same time, the microcontroller 5 controls the operation of the array electrode control module 3, thereby controlling each electrode in the array-type radiofrequency electrode 4 to independently select the radiofrequency voltage or power and output it to the treatment tissue for treatment. Meanwhile, the system collects the radiofrequency voltage, current, and treatment temperature in real time during the treatment process, transmits them to the microcontroller 5 for processing, adjusts the output power of the radiofrequency ablation system 1 in real time, and uploads it to the control module 6 as control feedback for the array-type radiofrequency electrode control algorithm to adjust the parameters of the array electrodes.

[0051] like Figure 2 As shown, the present invention provides an independent electrode control method for an array-type electrode group, wherein the control method mainly includes the following steps:

[0052] S1: Obtain radiofrequency ablation information;

[0053] S2: Based on the specific ablation situation and the target area to be ablated, a radiofrequency treatment plan is derived;

[0054] S3: According to the planning scheme, select the corresponding radio frequency electrode n in the electrode array, select the applied cooling parameters including cooling temperature Tf and flow rate Vf, and take n+2 control parameters as decision variables;

[0055] S4: Based on optimization algorithms and data-driven algorithms, solve for the optimal decision variable values ​​of n+2 control parameters;

[0056] S5: Use the optimal decision variables obtained in S4 to control the output signals of each electrode, as well as the temperature Tf and flow rate Vf of the cold medium, and transmit the control parameters to the microcontroller 5 to control the output of the radiofrequency therapy module 1 and control the output radiofrequency voltage V1-Vn of the array radiofrequency electrode group.

[0057] S6: Real-time acquisition of temperature at corresponding locations in the target area, used as feedback input for the optimization algorithm, and real-time adjustment of the decision output variable values ​​of the optimization algorithm;

[0058] S7: Treatment ends when the planned treatment time is reached.

[0059] like Figure 3 The image shown is an illustration of the conformal ablation effect of simulating atherosclerotic plaques using an array-type electrode independent control device and control method provided by the present invention in this embodiment. Figure 3 a. In 3D, solid lines represent the target ablation plaque lesion site, dashed lines represent the ablation area obtained based on theoretical calculations, and circular areas represent the vascular lumen. Figure 3 b and 3e The dashed areas represent the thermal ablation denaturation areas obtained based on theoretical calculations, and the circular areas represent the blood vessel lumen; Figure 3 c, The gray-filled areas covering the surface of 3f represent the desired thermal ablation deformation areas. Figure 3 The scale is 1 mm.

[0060] Specifically, this experiment is based on 12 microelectrodes evenly distributed in the inner circle of the blood vessel lumen. Figure 3 For the target ablation area in c and 3f, select the corresponding electrode as the working electrode and connect it to the circuit. Use a biomimetic phantom to replace blood vessels and surrounding tissue. Figure 3 For the target ablation areas in steps c and 3f, the optimal ablation parameters (V1~Vn, Tf=24℃, Vf=6.2m / s) were obtained based on a genetic algorithm and used as input parameters for the radiofrequency control system. Ablation was terminated after 1 minute. Finally, the difference between the actual ablated denatured area and the target ablated lesion was evaluated using CCD microscopy.

[0061] Based on existing research, this invention fully considers the generation principle of radiofrequency ablation signals and combines it with high-frequency transformer design to realize the division of a single radiofrequency source into multiple groups of radiofrequency ablation signals with the same frequency, phase, and different voltage amplitudes. These signals can be applied to tissues simultaneously, allowing different radiofrequency voltages to be applied to each electrode in the array electrode simultaneously without mutual interference or distortion, thereby achieving the purpose of conformal ablation of the ablated tissue.

[0062] The preferred embodiments of the present invention have been described in detail above. It should be understood that those skilled in the art can make numerous modifications and variations based on the concept of the present invention without creative effort. Therefore, all technical solutions that can be obtained by those skilled in the art based on the concept of the present invention through logical analysis, reasoning, or limited experimentation on the basis of existing technology should be within the scope of protection defined by the claims.

Claims

1. An array electrode group electrode independent control device characterized by comprising: The application relates to a radio frequency ablation system, which comprises a radio frequency generating device, a radio frequency isolation and voltage division module, an electrode independent control module, an array type electrode group, a microcontroller, a control module and an input and display module. The radio frequency isolation and voltage division module is used for isolating and dividing one radio frequency source into multiple groups of radio frequency ablation signals with the same frequency, the same phase, different power or voltage through a high-frequency transformer; the radio frequency isolation and voltage division module comprises a high-frequency transformer isolation circuit and a load matching circuit; the high-frequency transformer isolation circuit converts the input radio frequency signal into multiple groups of radio frequency ablation signals with the same frequency and the same phase; the radio frequency ablation signals are matched to the rated impedance of the radio frequency ablation signal source through the load matching circuit, so that the output power of the radio frequency is not distorted; The electrode independent control module comprises multiple pluggable electrode control modules, each of which controls one electrode; during the treatment process, the corresponding electrode module is inserted according to the actual number of electrodes used; The array type electrode group is used for system control of the working of the electrode group.

2. The apparatus according to claim 1, wherein The radio frequency generating device comprises a radio frequency ablation signal source and a cold circulation system; the radio frequency ablation signal source is connected with the cold circulation system; and the cold circulation system is arranged in a pipeline in the space of the radio frequency generating device.

3. The apparatus according to claim 1, wherein The electrode independent control module mainly comprises a multiple line decoding circuit and a radio frequency electrode control circuit.

4. The apparatus according to claim 1, wherein The control module is used for outputting the control scheme and control parameters of each electrode in real time and rapidly according to the actual ablation condition, and the control scheme and control parameters are transmitted to the microcontroller, so that the working polarity and selected radio frequency voltage or power of each electrode are controlled through the microcontroller.

5. The apparatus according to claim 4, wherein The control module is an industrial computer.

6. The apparatus according to claim 1, wherein The input and display module adopts a touch display screen design and is used for displaying the radio frequency ablation planning scheme, inputting the working parameters of the system, selecting the working mode of the corresponding electrode and displaying the ablation parameters in real time.

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