Biomedical sample capture access system

Abstract

A biological medicine sample capturing and accessing system comprises a sample bottle accessing mechanism, a sample bottle storage unit, an automatic sealing mechanism, a gas conveying mechanism and a transition transfer mechanism, which are sequentially arranged from top to bottom; the sample bottle accessing mechanism comprises a support, a sample bottle transfer mechanism, a moving mechanism and a driving mechanism, the sample bottle transfer mechanism comprises a sample bottle transfer chamber, a sample bottle capturing channel, a sample bottle storage channel, a sample bottle delivery channel and a sample bottle return channel, the sample bottle return channel is connected with a flexible connecting pipe, the driving mechanism drives the flexible connecting pipe to be connected with the sample bottle storage unit or drives the sample bottle storage channel or the sample bottle delivery channel to be connected with the transition transfer mechanism. Each part constitutes a closed sample bottle storage and accessing system in a required environment, and the system realizes closed and efficient storage and batch rapid taking out of samples in an ultralow-temperature environment.

Description

Technical Field

[0001] This invention relates to a device for sample storage in the biomedical field, belonging to the field of sample storage technology. Background Technology

[0002] The proper collection, analysis, and preservation of biopharmaceutical samples are crucial for sustainable research in biopharmaceuticals. Typically, experiments are not conducted immediately after sample collection. Some samples require repeated testing and comparison of results, while others are intended for future use in emerging technologies.

[0003] Samples used in pharmaceutical and medical research have stringent requirements for storage environment. The quality of samples is primarily affected by storage temperature, humidity, and time, especially for items with demanding storage conditions; even minor changes in the storage environment can affect their quality. Some samples are hard-won, and their loss or spoilage can cause irreparable damage. The safe storage and management of samples is a critical issue that urgently needs to be addressed, especially the scientific management of samples in laboratories, which is crucial for the rapid development and orderly operation of the entire laboratory.

[0004] Samples generally need to be stored in a frozen or refrigerated environment, and will also be taken out of the frozen or refrigerated environment. In either case, the door of the refrigerated environment (such as a refrigerator or freezer) needs to be opened. Sometimes this is done frequently, which causes air convection between the inside and outside, causing fluctuations in the refrigerated environment (temperature, humidity, etc.) and affecting the stability of the storage environment.

[0005] The quality of stored samples is mainly affected by storage temperature, humidity, and time, especially for items with stringent storage requirements, where even minor changes in the storage environment can affect their quality. Currently, storage methods still rely on traditional refrigerators or freezers. These methods involve repeated freezing and humidity fluctuations, which can easily degrade samples. Furthermore, the need for extensive searching during storage increases the risk of samples being missed. Additionally, there is a lack of standardized procedures for sample characterization and usage records.

[0006] CN102358485A discloses a pneumatic rotary sample library, comprising a central shaft, sample storage discs, a disc drive mechanism, a lifting device, and an adsorption conveying device. The sample storage discs are mounted parallel to each other on the central shaft, with sealing gaskets between adjacent discs. Sample nests and sample transfer channels are distributed on the discs, and each disc is connected to a disc drive mechanism. The lifting device is located below the bottom sample storage disc and includes a lifting jet pipe and a jet control valve. The adsorption conveying device is located above the top sample storage disc and includes a combined suction seat, suction pipe, suction control valve, conveying pipe, conveying control valve, and vacuum chamber. This sample library stores samples in a sealed environment and achieves automatic sample storage and retrieval through pneumatic technology, solving the problem of storing as many samples as possible in a limited space. However, it suffers from problems such as "high manufacturing cost of the sample storage discs and inability of the central shaft and sample storage discs to adapt to ultra-low temperature environments," preventing operation in such conditions. Summary of the Invention

[0007] This invention addresses the shortcomings of existing sample storage technologies by providing a capture and retrieval system with large capacity that enables rapid batch storage and retrieval of biological samples in ultra-low temperature environments.

[0008] The biomedical sample capture and retrieval system of the present invention adopts the following technical solution:

[0009] The system includes a sample bottle retrieval mechanism, a sample bottle storage unit, a self-sealing mechanism, a gas delivery mechanism, and a transition transfer mechanism, which are arranged sequentially from top to bottom.

[0010] The sample bottle storage and retrieval mechanism includes a support, a sample bottle transfer mechanism, a moving mechanism, and a driving mechanism. The moving mechanism and driving mechanism are both mounted on the support. The sample bottle transfer mechanism is connected to the moving mechanism. The sample bottle transfer mechanism includes a sample bottle transfer chamber and a sample bottle capture channel, a sample bottle inlet channel, a sample bottle outlet channel, and a sample bottle return channel connected to the sample bottle transfer chamber. Both the sample bottle outlet channel and the sample bottle return channel are equipped with vacuum ports (used to create a negative pressure zone through vacuuming to suck the sample bottles out of the sample bottle transfer chamber). The sample bottle return channel is connected to a flexible connecting tube. At least one driving mechanism is provided, driving the flexible connecting tube to connect with the sample bottle storage unit (specifically, the storage tube within the sample bottle storage unit), or driving the inlet sample bottle channel or the outlet sample bottle channel to connect with the transition transfer mechanism (specifically, the sample bottle transfer channel within the transition transfer mechanism).

[0011] Furthermore:

[0012] The moving mechanism consists of two sets of lead screw and nut pairs arranged in parallel on the support.

[0013] The sample bottle transfer chamber is equipped with an identification device that can accurately identify QR codes and RFID tags on the sample bottles.

[0014] Control valves are installed in the pipes connected to the sample bottle inlet channel, sample bottle outlet channel, and sample bottle return channel.

[0015] The sample bottle capture channel is one or more. Using a multi-channel arrangement of sample bottle capture channels can improve efficiency.

[0016] The sample bottle transfer chamber is T-shaped with a sloping bottom. The slope of the bottom facilitates the sliding of sample bottles down the slope. The bottom of the sample bottle transfer chamber is made into a rectangular trough for collecting sample bottles, with multiple sample bottle inlets and outlets evenly distributed on the side. The rectangular trough has two symmetrically installed identification devices on two opposite sides; on the other two opposite sides are respectively installed sample bottle outflow channels, sample bottle inflow channels, and sample bottle return channels, with the inflow and return channels on the same side.

[0017] The drive mechanism includes a main drive mechanism and a secondary drive mechanism, with the secondary drive mechanism connected to the power output end of the main drive mechanism. The main drive mechanism employs a lead screw and nut pair moving mechanism. The secondary drive mechanism employs an electric telescopic gripper, including an electric telescopic frame and a gripper. The electric telescopic frame is connected to the power output end of the main drive mechanism, and the gripper is connected to the end of the electric telescopic frame.

[0018] The sample bottle storage unit adopts a bundled tube structure, including a sealed box. A refrigerant exchange port is provided on the side wall of the sealed box. Storage tubes are vertically distributed inside the sealed box. The storage tubes are fixed by tube plates at the upper and lower ends of the sealed box. Both the upper and lower ends of the storage tubes are open.

[0019] The sealing mechanism includes a heat insulation frame and an upper partition, a middle partition, and a lower partition connected from top to bottom within the heat insulation frame. The upper partition has upper through holes with vent grooves engraved on their inner walls. The middle partition has circular through holes, each containing a sealing ball; the diameter of the circular through hole is larger than the diameter of the sealing ball. The lower partition has lower through holes. The diameter of the sealing ball is smaller than the inner diameter of the circular through hole but larger than the inner diameters of the upper and lower through holes. The distribution of the upper, circular, and lower through holes is consistent with the distribution of the storage tubes in the sample bottle storage unit. An arc-shaped spherical surface can be provided at the upper end of the lower through hole, with the diameter of the arc-shaped spherical surface not larger than the diameter of the sealing ball.

[0020] The gas delivery mechanism includes a frame, a gas delivery nozzle, a gas storage chamber, a gas delivery channel, and a transmission device. The transmission device is mounted on the frame, the gas storage chamber is connected to the transmission device, the gas delivery nozzle is connected to the gas storage chamber via a control valve, and the gas delivery channel is connected to the gas storage chamber. Gas is delivered into the gas storage chamber through the gas delivery channel. The transmission device drives the gas storage chamber to move, causing the gas delivery nozzle to align with the sealing mechanism (specifically, the lower through hole on the lower partition).

[0021] The transition transfer mechanism includes a sample bottle transfer channel, a sample bottle inlet / outlet, a transition transfer chamber, and a gas delivery pipe. The sample bottle transfer channel is connected above the transition transfer chamber. The transition transfer chamber contains a three-dimensional moving platform, a transition chamber, a sample bottle tray, and a transfer bracket. The transfer bracket is installed at the power output end of the three-dimensional moving platform. The transition chamber includes a frame and a tray. The tray is fixed in the frame, and the sample bottle tray is placed on the tray. The gas delivery pipe is located on the side wall of the transition chamber, with one end inside the chamber opposite the port of the sample bottle transfer channel, and the other end connected to a gas delivery mechanism (specifically, a gas delivery nozzle within the gas delivery mechanism). The sample bottle tray has a sample bottle placement hole on its body, and a transport slot at the bottom. The sample bottle placement hole is a stepped through-hole with a larger diameter at the top and a smaller diameter at the bottom. The sample bottle is placed at the top of the sample bottle placement hole, and the bottom of the hole is used for gas entry to blow the sample bottle out. The transfer tray is equipped with a transport claw, which has an air guide hole (when the sample bottle tray is placed on the transfer tray, the air guide hole corresponds to the sample bottle placement hole above it). When the sample bottle tray is transferred, the transport claw is inserted into the transport slot, and the gas enters the sample bottle placement hole through the through hole on the transport claw, blowing the sample bottle out.

[0022] The above system is placed in a temperature and humidity control box, or in other environments required for sample bottle storage, forming a closed sample bottle storage and retrieval system. The sample bottles containing the samples are stored in the sample bottle storage unit. Through the combined action of the sample bottle storage and retrieval mechanism, sealing mechanism, gas supply mechanism and transition transfer mechanism, the process of storing, retrieving and storing the sample bottles is completed.

[0023] This invention has the following characteristics:

[0024] 1. The sample bottle retrieval mechanism adopts a multi-channel arrangement of sample bottle grabbing channels, which is conducive to retrieving sample bottles simultaneously through multiple channels and improving the speed of sample bottle retrieval.

[0025] 2. The sample bottle storage and retrieval mechanism uses a sample bottle transfer chamber, which can quickly collect a large number of samples and perform rapid screening, thus satisfying the requirement for rapid sample retrieval.

[0026] 3. The sample transfer chamber is designed in a "T" shape with a certain slope on the bottom surface, which makes it easy for the sample bottle to slide down the slope.

[0027] 4. The bottom of the sample bottle transfer chamber is made into a rectangular trough for collecting sample bottles, with multiple sample bottle inlets evenly distributed on the side.

[0028] 5. The rectangular slot of the sample bottle transfer compartment has a rectangular opening on each corresponding side for symmetrical installation of two identification devices; a hole is opened on one of the other two sides for installing the sample bottle outbound channel, and two holes are opened on the corresponding side, one for installing the sample bottle inbound channel mechanism and the other for installing the sample bottle return channel.

[0029] 6. Placing the storage tube in a sealed box allows the sample vials to enjoy a unique temperature and humidity storage environment, meeting the environmental requirements for sample storage. At the same time, it can also create a lower storage temperature environment to meet the specific sample storage requirements.

[0030] 7. Placing the storage tube in a sealed box prevents heat leakage, facilitating the creation of a storage environment below -25°C. This allows the use of conventional materials, devices, components, and mechanisms, reducing equipment costs and improving safety and reliability. It meets the requirements for conventional actuators operating in environments above -25°C (>-25°C).

[0031] 8. The self-sealing mechanism achieves autonomous and efficient sealing by relying on the mass of the sealing ball and the principle of universal gravitation, thereby improving the stability and reliability of the system.

[0032] 9. The gas storage chamber in the gas transmission mechanism can be equipped with multiple gas transmission mechanisms, which reduces the number of gas transmission pipes, achieves balanced distribution of gas source, reduces airflow fluctuations, and improves the stability of gas transmission.

[0033] 10. The transition and transfer mechanism is equipped with multiple trays and a three-dimensional moving platform, which allows the sample bottle tray to move in the X, Y, and Z axes.

[0034] 11. The sample bottle tray is equipped with sample bottle placement holes, which are stepped through holes, and the sample bottles are stored through pneumatic conveying.

[0035] 12. The bottom of the sample bottle tray is equipped with a transport slot, and the transfer bracket is equipped with transport claws. When the sample bottle tray is transferred, the transport claws are inserted into the transport slot, which realizes the safe and reliable transfer of sample bottles. Attached Figure Description

[0036] Figure 1 This is a schematic diagram of the overall structure of the biomedical sample capture and storage system of the present invention.

[0037] Figure 2 This is a schematic diagram of the sample bottle storage and retrieval mechanism in this invention.

[0038] Figure 3This is a schematic diagram of the sample bottle transfer mechanism in this invention.

[0039] Figure 4 This is a schematic diagram of one side of the sample bottle transfer compartment of the sample bottle storage and retrieval mechanism.

[0040] Figure 5 This is a schematic diagram of the other side (three-dimensional) of the sample bottle transfer chamber of the sample bottle storage and retrieval mechanism.

[0041] Figure 6 This is a schematic diagram of the sample bottle retrieval mechanism in this invention, showing the structure of the sample bottle retrieval channel.

[0042] Figure 7 This is a schematic diagram of the sample bottle return channel of the sample bottle storage and retrieval mechanism in this invention.

[0043] Figure 8 This is a schematic diagram of the drive mechanism of the sample bottle storage and retrieval mechanism in this invention.

[0044] Figure 9 This is a schematic diagram of the flexible connecting tube in this invention.

[0045] Figure 10 This is a schematic diagram of the sample bottle storage unit in this invention.

[0046] Figure 11 This is a schematic diagram showing the state of the sample bottles inside the storage tube in the sample bottle storage unit.

[0047] Figure 12 This is a schematic diagram of the self-sealing mechanism in this invention.

[0048] Figure 13 This is a schematic diagram of the upper partition of the self-sealing mechanism in this invention.

[0049] Figure 14 This is a schematic diagram of the partition plate in the self-sealing mechanism of this invention.

[0050] Figure 15 This is a schematic diagram of the structure of the lower partition of the self-sealing mechanism in this invention.

[0051] Figure 16 This is a schematic diagram of the gas delivery mechanism in this invention.

[0052] Figure 17 This is a schematic diagram of the gas storage chamber structure in the gas transmission mechanism of this invention.

[0053] Figure 18 This is a schematic diagram of the transition mechanism in this invention.

[0054] Figure 19 This is a schematic diagram of the sample bottle transfer channel in the transition transfer mechanism.

[0055] Figure 20 This is a structural diagram of the transition transfer chamber in the transition transfer mechanism.

[0056] Figure 21 This is a schematic diagram of the transition chamber in the transition transfer mechanism.

[0057] Figure 22 This is a schematic diagram of the sample bottle tray in the transition transfer chamber.

[0058] Figure 23 This is a schematic diagram of the transfer tray in the transition transfer compartment.

[0059] Figure 24 This is a schematic diagram of the gas pipeline structure in the transition and transfer chamber.

[0060] Among them: 1. Temperature and humidity control box, 2. Sample bottle storage and retrieval mechanism, 3. Refrigeration control unit, 4. Sample bottle storage unit, 5. Self-sealing mechanism, 6. Gas delivery mechanism, 7. Transition and transfer mechanism;

[0061] 21. Motor; 22. Support; 23. Sample bottle transfer mechanism; 24. Lead screw and nut pair moving mechanism; 25. Lead screw and nut pair moving mechanism; 26. Motor;

[0062] 231. Sample bottle capture channel; 232. Sample bottle transfer compartment; 233. Identification device; 234. Sample bottle inbound channel; 235. Sample bottle outbound channel; 236. Sample bottle return channel;

[0063] 2321. Sample bottle sorting bin; 2322. Sample bottle inlet; 2323. Return sample bottle inlet; 2324. Inbound sample bottle inlet; 2325. Outbound sample bottle inlet; 2326. Identification device installation port.

[0064] 2351. Sample bottle outbound channel pipe interface, 2352. Sample bottle outbound channel vacuum port, 2353. Sample bottle outbound channel pipe interface, 2361. Sample bottle return channel pipe interface, 2362. Sample bottle return channel vacuum port, 2363. Sample bottle return channel pipe interface;

[0065] 251. Main drive mechanism, 252. Secondary drive mechanism, 253. Hinge, 254. Robotic arm, 255. Flexible connecting tube, 2551. Capturing nozzle, 2552. Flexible tube, 2553. Interface;

[0066] 41. Sealed box; 42. Storage tube; 43. Sample bottle; 411. Refrigeration medium exchange port;

[0067] 51. Insulation frame; 52. Upper partition; 53. Sealing ball; 54. Middle partition; 55. Lower partition;

[0068] 521. Upper partition through hole; 522. Ventilation groove; 541. Middle partition channel; 551. Lower partition channel hole; 552. Arc-shaped spherical surface;

[0069] 61. Frame, 62. Gas delivery nozzle, 63. Control valve, 64. Gas storage tank, 65. Gas delivery port, 66. Transmission device, 641. Gas storage tank body, 642. Valve interface, 643. Gas delivery interface;

[0070] 71. Sample bottle transfer channel; 72. Transition transfer chamber; 73. Rear cover; 74. Front cover; 75. Sample bottle storage port;

[0071] 711. Interface; 712. Transfer tube body; 713. Sample bottle inlet / outlet;

[0072] 721. Three-dimensional moving platform; 722. Transition chamber; 723. Sample bottle tray; 724. Transfer bracket; 725. Gas delivery pipe;

[0073] 7221. Shelf; 7222. Mounting hole; 7223. Pallet;

[0074] 7231. Sample bottle tray body; 7232. Sample bottle placement hole; 7233. Transfer slot;

[0075] 7241. Handling claw; 7242. Mounting surface; 7243. Air vent; 7244. Positioning platform;

[0076] 7251. Gas inlet, 7252. Gas pipe body, 7253. Gas inlet. Detailed Implementation

[0077] The biomedical sample capture and retrieval system of the present invention, such as Figure 1 As shown, the system includes a sample bottle retrieval mechanism 2, a sample bottle storage unit 4, a self-sealing mechanism 5, a gas supply mechanism 6, and a transition transfer mechanism 7. These components are arranged sequentially from top to bottom. The transition transfer mechanism 7 is located on one side of the sample bottle storage unit 4 and connects with the sample bottle retrieval mechanism 2 and the gas supply mechanism 6. The entire system is housed within a temperature and humidity control box 1, which contains a refrigeration control unit 3. It can also be placed in other environments required for sample bottle storage, forming a sealed sample bottle storage and retrieval system. The sample bottles 43 containing the samples are stored in the sample bottle storage unit 4. Through the combined action of the sample bottle retrieval mechanism 2, the self-sealing mechanism 5, the gas supply mechanism 6, and the transition transfer mechanism 7, the process of storing, retrieving, and storing the sample bottles is completed.

[0078] The following is a detailed description of the specific structure of each unit.

[0079] 1. Sample bottle storage and retrieval mechanism

[0080] like Figure 2 As shown, the sample bottle storage and retrieval mechanism 2 includes a support 22, a sample bottle transfer mechanism 23, a moving mechanism 24, and a driving mechanism 25. The moving mechanism 24 and the driving mechanism 25 are both mounted on the support 22, and the sample bottle transfer mechanism 23 is connected to two sets of moving mechanisms 24.

[0081] The moving mechanism 24 consists of two sets of lead screw and nut pairs, parallel to each other on the support 22. Each set of lead screw and nut pairs is driven by a motor 21. The two ends of the sample bottle transfer mechanism 23 are connected to the nuts in the two sets of lead screw and nut pairs 24. The motor 21 drives the lead screw and nut pairs, and the two sets of lead screw and nut pairs move the sample bottle transfer mechanism 23 (sample bottle transfer chamber 232).

[0082] like Figure 3 As shown, the sample bottle transfer mechanism 23 includes a sample bottle transfer chamber 232 and sample bottle capture channels 231, sample bottle inlet channels 234, sample bottle outlet channels 235, and sample bottle return channels 236 connected to the sample bottle transfer chamber 232. The sample bottle transfer chamber 232 is equipped with an identification device 233, such as a QR code reader or RFID reader, which can accurately identify QR codes and RFID tags on the sample bottles. Control valves are installed in the pipes connected to the sample bottle inlet channels 24, inlet channels 26, and return channels 28. These control valves open or close in real time according to instructions, determining the destination path of the sample bottles. The sample bottle capture channels 231, inlet channels 234, outlet channels 235, and return channels 236 move with the sample bottle transfer chamber 23.

[0083] like Figure 4 and Figure 5As shown, the sample bottle transfer chamber 232 is constructed on the sample bottle sorting chamber 2321, with sample bottle inlet 2322, return sample bottle outlet 2323, inlet sample bottle outlet 2324, outlet sample bottle outlet 2325, and identification device mounting port 2326 respectively for installing the sample bottle grabbing channel 231, sample bottle return channel 236, sample bottle inlet channel 234, sample bottle outlet channel 235, and identification device mounting port 2326. The sample bottle sorting chamber 321 is designed in a "T" shape with a certain slope on the bottom surface to facilitate the sliding of sample bottles on the lower part of the slope. The bottom surface is made into a rectangular trough shape for collecting sample bottles, and multiple sample bottle inlets and outlets are evenly distributed on the side. The identification device installation port 326 is opened on two opposite sides of the rectangular trough, and two symmetrical identification devices 33 are installed. On one of the other two opposite sides, there is an outbound sample bottle port 325 for installing a sample bottle outbound channel 35, and on the other side, there is a return sample bottle port 323 and an inbound sample bottle port 324 for installing a sample bottle return channel 36 and a sample bottle inbound channel 34, respectively.

[0084] like Figure 6 As shown, the sample bottle outlet channel 235 is designed as an "L"-shaped tube with rounded corners, and it is equipped with a sample bottle outlet channel tube interface 2351, a sample bottle outlet channel vacuum port 2352, and a sample bottle outlet channel tube interface 2353. The sample bottle outlet channel tube interface 2351 connects to the sample bottle outlet 2325 on the sample bottle sorting chamber 2321. A branch pipe is set near the sample bottle outlet channel tube interface 2351 (which can also be called the sample transfer chamber 232) as the sample bottle outlet channel vacuum port 2352, which is used to create a vacuum and generate a negative pressure zone, so that the sample bottle 43 is sucked out of the sample bottle transfer chamber 232 through the sample bottle outlet channel tube interface 2351 and enters the sample bottle outlet channel 235.

[0085] like Figure 7 As shown, the sample bottle return channel 236 has the same structure as the sample bottle outgoing channel 235, and is also designed as an "L"-shaped tube with rounded corners. It is equipped with a sample bottle return channel tube interface 2361, a sample bottle return channel vacuum port 2362, and a sample bottle return channel tube interface 2363. The sample bottle return channel tube interface 2361 connects to the return sample bottle port 2323 on the sample bottle sorting chamber 2321. A branch pipe is set near the sample bottle return channel tube interface 2361 (which can also be referred to as the sample transfer chamber 232) as the sample bottle return channel vacuum port 2362, used for vacuuming to create a negative pressure zone, drawing the sample bottle 43 from the sample bottle transfer chamber 232 through the sample bottle return channel tube interface 2361 and into the sample bottle return channel 236. The sample bottle return channel 236 is connected to a flexible connecting tube 255 (see...). Figure 9 ).

[0086] There are two sets of drive mechanisms 25, and the structure of each set is as follows: Figure 8As shown, the device includes a main drive mechanism 251 and a secondary drive mechanism 252, with the secondary drive mechanism 252 connected to the power output end of the main drive mechanism 251. The main drive mechanism 251 employs a lead screw and nut pair moving mechanism, with the lead screw mounted on a bracket 21 and connected to a drive motor 26, and the nut connected to the lead screw. The secondary drive mechanism 252 employs an electric telescopic gripper, which is existing technology, and includes an electric telescopic frame 253 and a gripper 254. The electric telescopic frame 253 is connected to the nut in the main drive mechanism, and the gripper 254 is connected to the end of the electric telescopic frame 253. The gripper 254 opens and closes under the drive of the electric telescopic frame 253, and is used to grip the flexible connecting pipe 255.

[0087] like Figure 9 As shown, the flexible connecting tube 255 has a catch nozzle 2551 and an interface 2553 at both ends of the flexible tube 2552. The catch nozzle 2551 and the interface 2553 are used to connect to the sample bottle return channel 236 (sample bottle return channel tube interface 2363), and the catch nozzle 2551 is used to dock with the upper port of the storage tube 42.

[0088] One set of drive mechanisms 25 is used to drive the flexible connecting tube 255 to dock with the storage tube 42 in the sample bottle storage unit 4 (the gripping nozzle 2551 docks with the upper end of the storage tube 42), forming a closed channel through which the sample bottle 43 passes. Another set of drive mechanisms 25 is used to grip the inbound sample bottle channel 234 or the outbound sample bottle channel 235 and dock with the sample bottle transfer tube 71.

[0089] The operation process of the above-mentioned sample bottle storage and retrieval mechanism 2 is as follows.

[0090] Sample bottles 43 are pneumatically conveyed from storage pipe 42 into sample bottle return channel 236, and then into sample bottle sorting chamber 2321 in sample bottle transfer chamber 232.

[0091] When the identification device 233 identifies the sample bottle 43 to be retrieved, it opens the vacuum port 2352 of the sample bottle outgoing channel 235. The sample bottle 43 is drawn in through the sample bottle outgoing channel tube interface 2351 and then enters the sample bottle transfer tube 71 of the transition transfer mechanism 7 through the sample bottle outgoing channel tube interface 2353 (at this time, the sample bottle outgoing channel tube interface 2353 of the sample bottle outgoing channel 235 is connected to the interface 711 of the sample bottle transfer tube 71). The sample bottle 43 then enters the transition transfer mechanism 7 through the sample bottle transfer tube 71, where the outgoing process is completed.

[0092] If it is not the sample bottle 43 to be retrieved, the vacuum port 2362 of the sample bottle return channel 236 is opened. The sample bottle 43 is sucked in through the sample bottle return channel tube interface 2361 and enters the flexible connecting tube 255 through the sample bottle return channel tube interface 2363. The grabbing nozzle 2551 is driven by the drive mechanism 25 and docks with the upper port of the corresponding storage tube 42. The sample bottle 43 enters the storage tube 42 and the return is completed.

[0093] When sample bottle 43 needs to be stored in sample bottle storage unit 4 (during storage), the drive mechanism 25 grasps the sample bottle inlet channel 234 and connects it with the sample bottle transfer tube 71 in the sample bottle transfer mechanism 7. Sample bottle 43 enters the sample bottle transfer chamber 232 through the sample bottle inlet channel 234 via the sample bottle transfer mechanism 7. Vacuuming begins at 2632 of the sample bottle return channel 236. Under negative pressure, the sample bottle enters the sample bottle return channel 2361 and enters the flexible connecting tube 255 through the sample bottle return channel tube interface 2363. The grasping nozzle 2551, driven by the drive mechanism 25, connects with the upper port of the corresponding storage tube 42, and the sample bottle 43 enters the storage tube 42, completing the storage process.

[0094] 2. Sample bottle storage unit

[0095] Sample bottle storage unit 4 adopts a bundled tube structure, such as Figure 10 As shown, the system includes a sealed box 41. A refrigerant exchange port 411 is provided on the side wall of the sealed box 41. Storage tubes 42 are vertically arranged inside the sealed box 41. The storage tubes 42 are fixed by tube plates at both ends of the sealed box 41 (the tube plates have holes with the same outer diameter as the storage tubes 42). Both ends of the storage tubes 42 are open. The storage tubes 42 are used to store sample bottles 43, such as... Figure 11 As shown. The functions of the sealed box 41 are: firstly, to provide the sample storage unit with an independent and stable temperature and humidity environment, the temperature of which can be below -25℃; secondly, to isolate the sample storage unit 4 from other institutions or units, so that it has its own exclusive temperature and humidity environment.

[0096] 3. Self-sealing mechanism

[0097] like Figure 12 As shown, the self-sealing mechanism 5 includes a heat insulation frame 51 and an upper partition 52, a middle partition 54, a sealing ball 53, and a lower partition 55 connected together from top to bottom.

[0098] like Figure 13 As shown, the upper partition 52 has through holes 521 distributed on it, and multiple ventilation grooves 522 are engraved on the inner wall of the through holes. The diameter of the through holes 521 is smaller than the diameter of the sealing ball 53, which serves to restrict the sealing ball 53. The outer diameter of the ventilation groove 522 is approximately the same as the diameter of the through hole 541, which is the channel for high-pressure gas to enter the storage pipe 42.

[0099] like Figure 14 As shown, the partition plate 54 has through holes 541 distributed on it, and a sealing ball 53 is installed inside the through hole 541. The diameter of the through hole 541 is larger than the diameter of the sealing ball 53, which is the suspension area of ​​the sealing ball and also the channel through which high-pressure gas flows.

[0100] like Figure 15 As shown, the lower partition plate 55 has through holes 551 distributed on it, and it is rounded and chamfered to form an arc-shaped spherical surface 552. The diameter of the arc-shaped spherical surface 552 is not greater than the diameter of the sealing ball 53. When the sealing ball 53 loses the external pressure, it falls into the spherical arc surface 552 by its own weight, sealing the through holes 551 of the lower partition plate.

[0101] The diameter of the sealing ball 53 is smaller than the inner diameter of the through hole 551 and larger than the through holes 521 and 551 of the upper partition and the lower partition. The distribution of the through holes 521, 541 and 551 of the upper partition is consistent with the distribution of the storage tubes in the sample bottle storage unit (coaxial and corresponding one-to-one).

[0102] 4. Gas transmission mechanism

[0103] like Figure 16 and Figure 17 As shown, the gas delivery mechanism 6 includes a frame 61, a gas delivery nozzle 62, a control valve 63, a gas storage chamber 64, a gas delivery channel 65, and a transmission device 66. The gas storage chamber 641 is equipped with multiple valve ports 642 and one gas delivery port 643. The transmission device 66 is mounted on the frame 61 and employs a screw-nut pair moving mechanism. The screw is mounted on the frame 61, and the nut is connected to the screw. The gas storage chamber 64 is connected to the nut. The gas delivery nozzle 62 is connected to the valve ports 642 of the gas storage chamber 64 via the control valve 63. The gas delivery channel 65 is connected to the gas delivery port 643 of the gas storage chamber 64, and the gas delivery channel 65 delivers high-pressure gas into the gas storage chamber 64. The transmission device 66 drives the gas storage chamber 64 to move.

[0104] The operation process of the gas delivery mechanism 6 and the self-sealing mechanism 5 is as follows:

[0105] Under the control of the transmission mechanism 66, the gas delivery nozzle 62 aligns with a row of lower partition through holes 551 on the corresponding lower partition 55. High-pressure gas enters one or more corresponding lower partition through holes 551 on the lower partition 55 through the gas delivery nozzle 62. Under the action of the high-pressure gas, the sealing ball 53 is suspended in the corresponding middle channel 541 of the middle partition 54, and the sealing effect fails. The high-pressure gas then enters one or more storage tubes 42 through the corresponding venting groove 522 on the upper partition 52, pushing the sample bottle 43 in the storage tube 42 upward. When the gas pressure is released, the sealing ball 53 falls into the arc-shaped spherical surface 552 of the lower partition 55 by its own gravity, achieving a self-sealing effect. The sealing ball 53 must have a sufficiently high density so that it cannot suspend without the action of high-pressure gas flow.

[0106] 5. Transitional / Relocation Agency

[0107] like Figure 18 As shown, the transition transfer mechanism 7 includes a sample bottle transfer tube 71 and a transition transfer chamber 72. The sample bottle transfer tube 71 is connected to the top of the transition transfer chamber 72. A rear cover plate 73 is provided at the rear of the transition transfer chamber 72, and an openable front cover plate 74 is provided at the front. A sample bottle storage port 75 is provided on the front cover plate 74. The sample bottle 43 is transferred between the transition transfer chamber 72 and the sample bottle storage and retrieval mechanism 2 through the sample bottle transfer tube 71.

[0108] like Figure 19 As shown, the sample bottle transfer tube 71 has interfaces 711 and sample bottle inlets / outlets 713 at both ends of the transfer tube body 712. The transfer tube body 712 enters the transition chamber 722 through the mounting hole 7222. The interface 711 connects to the capture port 2353 of the sample bottle outlet channel 235 in the sample bottle storage and retrieval mechanism 2, or to the lower port of the sample bottle inlet channel 234. The sample bottle 43 enters and exits the transition transfer chamber 72 through the sample bottle inlet / outlet 713. The sample bottle 43 is transferred between the transition transfer mechanism 7 and the sample bottle storage and retrieval mechanism 2 through the sample bottle transfer tube 71.

[0109] like Figure 20 As shown, the transition transfer chamber 72 is internally equipped with a three-dimensional moving platform 721, a transition chamber 722, a sample bottle tray 723, a transfer bracket 724, and a gas supply pipe 725. The three-dimensional moving platform 721 is existing technology and is installed inside the transition chamber 722. The transfer bracket 724 is installed at the power output end of the three-dimensional moving platform 721 and is driven by the three-dimensional moving platform 721 to perform three-dimensional movement (up / down, left / right, and forward / backward) to reach the desired position. The sample bottle tray 723 is placed on the pallet 7223 within the transition chamber 722. Figure 21As shown, the transition chamber 722 includes a frame 7221 and a tray 7223. The upper end of the frame 7221 has mounting holes 7222 for the sample bottle transfer tube 71, which connect to the sample bottle transfer tube 71. The tray 7223 is horizontally arranged and fixed in the frame 7221 for temporarily storing the sample bottle tray 723. A gas delivery pipe 725 is located on the side wall of the transition chamber 722 (specifically on the rear cover plate 73). One end of the gas delivery pipe 725 is positioned directly below the sample bottle inlet / outlet 713 of the sample bottle transfer tube 71 within the transition chamber 722. The distance between the gas delivery pipe 725 and the sample bottle transfer tube 71 is equal to the height of the sample bottle tray 723. The other end of the gas delivery pipe 725 is connected to a gas delivery nozzle 62 in the gas delivery mechanism 6.

[0110] like Figure 22 As shown, the sample bottle tray 723 has a sample bottle placement hole 7232 on the sample bottle tray body 7231, and a transport groove 7233 is provided at the bottom of the sample bottle tray body 7231. The sample bottle placement hole 7232 is a stepped through hole with a larger diameter at the top and a smaller diameter at the bottom. The sample bottle 43 is placed at the top, and the bottom is used to support the sample bottle 43 and allow gas to enter, blowing the sample bottle 43 out.

[0111] like Figure 23 As shown, the transfer bracket 724 includes a transport claw 7241, a mounting surface 7242, and a positioning stage 7244. One side of the transport claw 7241 is the positioning stage 7244, used to limit the placement position of the sample bottle tray 7231. The lower bottom surface of the positioning stage 7244 is the mounting surface 7242, used to connect with the three-dimensional moving platform 721. The transport claw 7241 is provided with a vent 7243, which corresponds to the sample bottle placement hole 7232 on the sample bottle tray 7231, ensuring that gas passage is not obstructed even when the sample bottle placement hole 7232 is directly below the transport claw 7241. When the sample bottle tray 723 is placed on the transfer bracket 7244, the transport claw 7241 will block the sample bottle placement hole 7232 on the sample bottle tray 7231 above it. The purpose of providing the vent 7243 is to allow gas to enter the sample bottle placement hole 7232 through the vent 7243. The transport claw 7241 is inserted into the transport slot 7233 at the bottom of the sample bottle tray 723, lifting the sample bottle tray 7231 and moving it in three dimensions within the transition chamber 722 along with the three-dimensional moving platform 721.

[0112] like Figure 24As shown, the gas supply pipe 725 has gas inlets 7251 and gas inlets 7253 at both ends of the gas supply pipe body 7252. The gas supply pipe body 7252 is mounted on the rear cover plate 73, and the gas inlets 7251 are located directly below the sample bottle inlet / outlet 713. The distance between the gas inlet 7251 and the sample bottle inlet / outlet 713 is the same as the height of the sample bottle tray 723 (the height of the transport claw 7241 is the same as the height of the transport slot 7233). The gas inlet 7253 is connected to a gas nozzle 62 in the gas supply mechanism 6.

[0113] The operation process of the aforementioned transition mechanism 7 is as follows.

[0114] Sample bottles 43 are placed in sample bottle placement holes 7232 on sample bottle tray 723. Sample bottle tray 723 enters and exits the transition mechanism 7 through sample bottle storage port 75, and the three-dimensional moving platform 721 realizes the transportation of sample bottle tray 723 between sample bottle pick-up and drop port 75 and shelf 7221.

[0115] When sample bottles 43 enter the outbound process, they pass through the sample bottle outbound channel 235 into the sample bottle transfer tube 71. Sample bottles 43 continuously exit from the sample bottle inlet / outlet 713. The sample bottle tray 723, driven by the three-dimensional moving platform 721, continuously moves, allowing empty sample bottle placement holes 7232 to receive the sample bottles 43 exiting from the inlet / outlet 713, placing each sample bottle 43 into its designated hole. When the sample bottle tray 723 is full of sample bottles 43, or when the number of sample bottles 43 retrieved meets the requirement (the sample bottle tray 723 is not yet full), the three-dimensional moving platform 721 temporarily places the sample bottle tray 723 onto the pallet 7223, or moves it out through the sample bottle storage port 75 via the transition mechanism 7, completing the outbound task.

[0116] When sample bottles 43 need to be stored in sample bottle storage unit 4 (during storage), sample bottles 43 are first placed in sample bottle placement holes 7232. Sample bottle trays 723 are placed into transition transfer chambers 72 through sample bottle storage openings 75 and placed on pallets 7223. The three-dimensional moving platform 721 drives the transport claws 7241 into the transport slots 7233 at the bottom of the sample bottle trays 723. To improve the speed at which sample bottle trays 723 enter the transition transfer mechanism 7, if too many sample bottle trays 723 are stored at once, they can be placed on pallets 7223 first. After all the sample bottle trays 723 to be stored have entered the transition transfer mechanism 7, the three-dimensional moving platform 721 drives the sample bottle trays 723 to move to a predetermined position (sample bottle inlet / outlet 713). At the same time, one of the drive mechanisms 25 grips the storage sample bottle channel 234 and connects it with the interface 711 of the sample bottle transfer tube 71 in the transition transfer mechanism 7. At this point, the air inlet 7251 of the gas supply pipe 725, the sample bottle placement hole 7232 on the sample bottle tray 723 where the corresponding sample bottle 43 is placed, and the sample bottle inlet / outlet 713 of the sample bottle transfer tube 71 are aligned. The control valve 63 controlling the gas supply nozzle 62 connected to the gas supply pipe 725 is opened, and high-pressure gas is blown through the gas supply port 7253 of the gas supply pipe 725 towards the sample bottle placement hole 7232, blowing the sample bottle 43 in the sample bottle placement hole 7232 into the sample bottle transfer tube 71. If the sample bottle placement hole 7232 is directly below the transport claw 7241, the gas blown from the gas supply port 7253 of the gas supply pipe 725 enters the sample bottle placement hole 7232 directly or through the air guide hole 7243, blowing the sample bottle out of the sample bottle placement hole 7232 and into the sample bottle transfer tube 71. Thus, sample bottles 43 are pneumatically transported one by one through sample bottle transfer tube 71 to sample bottle storage channel 234, and then enter sample bottle sorting bin 2321. Finally, the storage process is carried out according to the return process described in sample bottle storage and retrieval mechanism 2.

[0117] The operation process of the above-mentioned biomedical sample capture and storage system of the present invention is as follows.

[0118] When a specific sample bottle 43 needs to be retrieved, the gas delivery nozzle 62 moves under the control of the transmission device 66, aligning with a row of lower partition through holes 551 in the lower partition 55 of the self-sealing mechanism 5 corresponding to the lower port of the storage tube 42 where the sample bottle 43 is located. It then opens one or more control valves 63 according to instructions, delivering high-pressure gas to the corresponding storage tube 42. Simultaneously, the moving mechanism 24 drives the sample bottle transfer chamber 23 to move, and the sample bottle capture channel 231 follows the sample bottle transfer chamber 23 to the upper port of the storage tube 42 where the sample bottle 43 is located. A set of driving mechanisms 25 drives the sample bottle outflow channel 235 (sample bottle outflow channel pipe interface 2353) to align with the sample bottle transfer pipe 71 (interface 711), forming a complete outflow channel. High-pressure gas is controlled to be ejected from the gas delivery nozzle 62, passing through the channel corresponding to the self-sealing mechanism 5, entering the designated storage tube 42, and blowing the sample bottle 43 out of the storage unit 4, entering the sample bottle transfer chamber 232 through the sample capture channel 231. Inside the sample bottle transfer chamber 232, sample bottle information is captured by the identification device 233. When the identification device 233 identifies the sample bottle 43 to be retrieved, it opens the vacuum port 2352 of the sample bottle outgoing channel 235. The sample bottle 43 is drawn in through the sample bottle outgoing channel pipe interface 2351 and enters the sample bottle transfer tube 71 of the transition transfer mechanism 7 through the sample bottle outgoing channel pipe interface 2353. The sample bottle 43 then enters the transition transfer mechanism 7 through the sample bottle transfer tube 71, where the outgoing process is completed.

[0119] If it is not the sample bottle 43 to be retrieved, the drive mechanism 25 drives the two ends of the flexible connecting tube 255 to connect with the sample bottle return channel 236 (sample bottle return channel tube interface 2361) and the upper port of the corresponding storage tube 42 respectively, forming a return channel; at the same time, the sample bottle return channel vacuum port 2362 in the sample bottle return channel 236 is opened, the sample bottle 43 is sucked in through the sample bottle return channel tube interface 2361, and enters the flexible connecting tube 255 through the sample bottle return channel tube interface 2363. The capture nozzle 2551 is connected with the upper port of the corresponding storage tube 42 under the drive of the drive mechanism 25, and the sample bottle 43 enters the storage tube 42, completing the return process.

[0120] When sample bottle 43 needs to be stored in sample bottle storage unit 4 (during warehousing), the sample bottle 43 is first moved into sample bottle placement hole 7232 according to the operation process described in the transition transfer mechanism 7. Then, the warehousing process is carried out according to the warehousing process described in the sample bottle storage and retrieval mechanism 2.

[0121] Specific embodiments are given below.

[0122] Temperature chamber 1 is designed to be 1200mm long, 1200mm wide, and 1800mm high, with a 50mm thick insulation layer, and is equipped with a temperature and humidity control system.

[0123] The sample bottle storage unit 4 is designed to be 1000mm long, 800mm wide, and 1000mm high. The storage tubes are made of acrylic round tubes with an inner diameter of Φ20mm, an outer diameter of Φ24mm, and a length of 900mm. The upper and lower tube plates are 1000mm long, 800mm wide, and 10mm thick, made of acrylic. Each tube has 33 stepped holes evenly distributed along its long side and 25 stepped holes evenly distributed along its short side, for a total of 825 stepped holes. The hole spacing is 30mm. The large hole of the stepped hole is Φ24mm, and the small hole is Φ20mm. First, the storage tubes are inserted one by one into the Φ24mm holes of the lower tube plate, then the storage tubes are inserted one by one into the Φ24mm holes of the upper tube plate and secured. The storage tube bundle is now complete. An insulation layer with a thickness of 50mm is installed around the longitudinal perimeter of the storage tube bundle. Four Φ100 cooling medium exchange holes are left on two symmetrical sides, with a spacing of 400mm between the holes on the same side, for installing cooling medium exchange ports. The sample bottle storage unit is now complete.

[0124] The sample bottle storage and retrieval mechanism 2 is designed as follows: The sample bottle transfer chamber 23 is designed in a "T" shape, with specific dimensions of 1000mm in length, 800mm in width, and 200mm in height. A 100mm high groove is created on the bottom surface for sample bottle collection, giving the bottom a slight slope to facilitate sliding of the sample bottles towards the lower slope. Thirty-three Φ20mm sample bottle inlet channels are evenly distributed on the sides, corresponding to the sample tube arrangement in the storage unit. On the extended cuboid below, a 20*50mm rectangular slot is opened on each corresponding side, 25mm from the bottom surface, for installing two identification devices. A Φ20mm hole is opened on one of the other two sides for installing the sample bottle outgoing channel, and two Φ20mm holes are opened on the corresponding sides, one for installing the sample bottle incoming channel mechanism and the other for installing the sample bottle return channel.

[0125] The sample bottle outbound channel and the sample bottle return channel have the same structure. They are designed with an "L" shaped tube with rounded corners, an inner diameter of Φ20mm, a corner radius of R60mm, and a wall thickness of 2mm. Near the sample bottle transfer chamber, a branch tube is set up for vacuuming, with an inner diameter of Φ10mm and a wall thickness of 2mm.

[0126] When the identification device recognizes the sample bottle to be retrieved, the sample bottle retrieval mechanism is activated, and the sample bottle is sucked out. If it is not the sample bottle to be retrieved, another mechanism is activated, and the sample bottle is sucked into the return channel.

[0127] The sample bottle outbound channel, sample bottle return channel, sample bottle inbound channel mechanism, and identification device are installed in the sample bottle transfer compartment. Then, together with the lead screw mechanism and drive motor, they are installed on the bracket, and the sample bottle storage and retrieval mechanism 2 is completed.

[0128] Fabrication of the self-sealing mechanism 5:

[0129] 1) Make an insulation frame with dimensions of 1000*800*35mm and an insulation layer thickness of 50mm.

[0130] 2) The upper partition is 1000mm long, 800mm wide and 10mm thick, made of engineering plastic, with 825 ventilation slots and through holes evenly distributed, corresponding one-to-one with the 825 holes of the storage unit tube bundle. The center distance of the outer hole is 140mm from the edge line, the inner diameter of the through hole is Φ10mm, the ventilation slot size is 15*2mm, and there are 6 evenly distributed ventilation slots.

[0131] 3) The pneumatic channel is 1000mm long, 800mm wide, and 15mm thick. It is made of engineering plastic and has 825 ventilation slots and holes that correspond one-to-one with the 825 holes on the upper partition. The center of the outer hole is 140mm from the edge line and the diameter of the hole is Φ15mm.

[0132] 4) The lower partition is 1000mm long, 800mm wide, and 10mm thick. It is made of stainless steel and has 825 ventilation slots and holes that correspond one-to-one with the 825 holes in the upper and middle partitions. The center of the outer hole is 140mm from the edge line, the diameter of the hole is Φ10mm, and the rounded chamfer is R2.

[0133] 5) The diameter of the gas sealing ball is Φ12mm.

[0134] 6. Install the lower partition, sealing ball, middle partition, and upper partition into the heat insulation frame in sequence, and connect them together with fasteners. The gas sealing mechanism is now assembled.

[0135] The refrigeration control unit, gas delivery mechanism, gas sealing mechanism, sample bottle storage unit, transition transfer mechanism, and sample bottle retrieval mechanism are assembled into one unit through auxiliary connectors and placed in the temperature control mechanism. Then, the relevant actuators are installed separately, and a multi-channel friction-type sample bottle retrieval system is assembled.

[0136] VI. Transitional Transfer Agency 7

[0137] 1) Front cover, designed to be 1000*1200*10mm, with a 300*100mm opening in the center.

[0138] 2) Transition compartment, designed to be 1000*1200*300mm, with a Φ22mm hole centered at the top.

[0139] 3) The rear cover plate is designed to be 1000*1200*10mm, with a Φ12mm hole centered 30mm from the bottom.

[0140] 4) Pallet, designed to be 200*140*10mm.

[0141] 5) Tray, designed to be 240*140*40mm, with 45 sample bottle placement holes evenly distributed. The placement holes are stepped through holes, with the upper part having a dimension of Φ=20mm and a depth of 30mm, and the lower part having a dimension of Φ10mm and a depth of 10mm. On the other side, there are two symmetrical 30*5mm slots with a spacing of 140mm.

[0142] 6) The transfer bracket is designed in a 200*150mm "U" shape. At the bottom of the "U" shape, a 200*10*20mm boss is created to restrict the tray's position. The claws are 140mm long, 30mm wide, and 5mm thick, with a 140mm distance between the two claws (corresponding to the tray's groove). Five Φ10mm holes are drilled on each claw, their positions corresponding to the tray's horizontal holes. A 30*50*20mm boss is created on the bottom edge of the "U" shape for connection to the 3D moving platform.

[0143] 7) Install the pallet and the three-dimensional moving platform onto the transition chamber in sequence, connect the transfer bracket to the three-dimensional moving platform, and connect the front cover plate and the rear cover plate to the transition chamber. The transition transfer mechanism is now complete.

Claims

1. A biomedical sample capture and retrieval system, characterized in that, It includes a sample bottle retrieval mechanism, a sample bottle storage unit, a self-sealing mechanism, a gas delivery mechanism, and a transition transfer mechanism, which are arranged sequentially from top to bottom; The sample bottle storage and retrieval mechanism includes a support, a sample bottle transfer mechanism, a moving mechanism, and a driving mechanism. Both the moving mechanism and the driving mechanism are mounted on the support. The sample bottle transfer mechanism is connected to the moving mechanism. The sample bottle transfer mechanism includes a sample bottle transfer chamber and a sample bottle capture channel, a sample bottle inlet channel, a sample bottle outlet channel, and a sample bottle return channel connected to the sample bottle transfer chamber. Both the sample bottle outlet channel and the sample bottle return channel are equipped with vacuum ports. The sample bottle return channel is connected to a flexible connecting tube. At least one driving mechanism is provided, which drives the flexible connecting tube to connect with the sample bottle storage unit, or drives the inlet sample bottle channel or the outlet sample bottle channel to connect with the transition transfer mechanism. The sample bottle storage unit adopts a bundled tube structure, including a sealed box. A refrigerant exchange port is provided on the side wall of the sealed box. Storage tubes are vertically distributed inside the sealed box. The storage tubes are fixed by tube plates at the upper and lower ends of the sealed box. Both the upper and lower ends of the storage tubes are open. The self-sealing mechanism includes a heat insulation frame and an upper partition, a middle partition, and a lower partition connected together from top to bottom within the heat insulation frame. The upper partition has upper through holes, and the inner wall of the upper through holes is engraved with ventilation grooves. The middle partition has round through holes, and a sealing ball is installed in the round through hole. The diameter of the round through hole is larger than the diameter of the sealing ball. The lower partition has lower through holes. The diameter of the sealing ball is smaller than the inner diameter of the round through hole but larger than the inner diameter of the upper and lower through holes. The distribution of the upper through holes, round through holes, and lower through holes is consistent with the distribution of the storage tubes in the sample bottle storage unit.

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