Biological sample processing device and biological detection system

Abstract

The present invention relates to a biological detection technology, and is used to solve the problem that the marking information on the outer side of a sample reagent tube cannot be read due to loose, misplaced, lost, blurred, etc., and the abnormal situation cannot be determined in time during the biological detection process. The present invention is specifically a biological sample processing device and a biological detection system, including a biological sample processing device; the present invention successively monitors and analyzes the positioning, position, firmness and clarity of the sample marking on the outer side of the sample reagent tube, and investigates the situation that the sample marking information cannot be read due to the sample reagent tube not being placed stably, the marking being posted in the wrong position, the sample marking being posted misplaced and loose, and the sample marking clarity changing, and determines the reasons why the sample marking information cannot be read or is read incorrectly, and corrects the error in time to prevent the error from being discovered in time, resulting in waste of sample resources, delays in experimental progress, and affecting the progress and results of scientific research projects.

Description

Technical Field

[0001] The present invention relates to biological detection technology, in particular to a biological sample processing device and a biological detection system. Background Art

[0002] Biological samples usually refer to the flowers, leaves, stems, roots, seeds, etc. of plants, body fluids (such as urine, blood, saliva, bile, gastric juice, lymph and other secretions of organisms, etc.), hair, muscles and some tissues and organs (such as thymus, pancreas, liver, lungs, brain, stomach, kidneys, etc.) of animals, and various microorganisms;

[0003] In the prior art, when a biological detection system processes a sample reagent in a corresponding reagent tube through a biological sample processing device, it is necessary to read the sample label information posted on the outside of the sample reagent tube and perform corresponding operations according to the type of the sample reagent. During the sample label reading process, the sample reagent information may be unable to be read or misidentified due to loose, misplaced, lost, blurred, etc., and the abnormal situation cannot be determined in time. The information reading error leads to sample confusion, inaccurate experimental data, waste of sample resources, and delay of experimental progress, which affects the progress and results of scientific research projects.

[0004] In view of the above technical problems, this application proposes a solution. Summary of the invention

[0005] The purpose of the present invention is to monitor and analyze the positioning, position, firmness and clarity of the sample mark on the outside of the sample reagent tube, and to investigate the situation that the sample mark information cannot be read due to the sample reagent tube being not placed stably, the mark being posted in the wrong position, the sample mark being posted misplaced and loose, and the sample mark clarity changing, and determine the cause of the sample mark information being unable to be read or reading errors, and correct the errors in time to prevent the errors from being discovered in time, resulting in waste of sample resources, delays in experimental progress, and affecting the progress and results of scientific research projects. The present invention solves the problem that the mark information on the outside of the sample reagent tube cannot be read due to loose, misplaced, lost, blurred, etc. marks, and the abnormal situation cannot be determined in time, resulting in sample confusion, inaccurate experimental data, waste of sample resources, and delays in experimental progress during biological detection. A biological sample processing device and a biological detection system are proposed.

[0006] The purpose of the present invention can be achieved through the following technical solutions:

[0007] Biological sample processing device and biological detection system, including:

[0008] The sample processing tube positioning detection module is used to monitor and analyze the position and angle of the reagent tube containing the sample to be processed placed in the biological sample processing device. If the reagent tube is placed in the correct position, the sample marking position detection module is executed, otherwise, the reagent tube position adjustment operation is performed;

[0009] The sample mark position detection module is used to monitor and analyze the position of the sample mark on the sample reagent tube placed in the biological sample processing device. If the position of the sample mark on the sample reagent tube is correct, the sample mark firmness detection module is executed, otherwise, the rubbing position adjustment operation is executed;

[0010] The sample mark firmness detection module is used to monitor and analyze the firmness of the sample mark on the sample reagent tube. If the sample mark on the sample reagent tube is firmly posted, the sample mark clarity detection module is executed, otherwise, the sample mark firmness operation is executed;

[0011] The sample mark clarity detection module is used to monitor and analyze the clarity of the sample mark on the sample reagent tube. If the sample mark on the sample reagent tube is clear and correct, the sample mark information reading module is executed, otherwise, the sample mark replacement operation is executed;

[0012] The sample label information reading module is used to read the sample label information on the sample reagent tube, and compare and analyze the sample read information with the previously recorded sample information. If the two types of sample information are compared correctly, the biological sample processing operation continues to be executed, otherwise, the biological sample processing operation stops.

[0013] As a preferred embodiment of the present invention, the position and angle of the reagent tube containing the sample to be processed placed in the biological sample processing device are monitored and analyzed, and the specific monitoring and analysis process is as follows:

[0014] The pressure data generated after the sample reagent tube is placed is monitored by the pressure sensors arranged around the inner wall and at the bottom of the sample reagent tube placement position in the biological sample processing device. After the sample reagent tube of a preset corresponding size is placed into the biological sample processing device, the pressure values ​​caused by the pressure sensors arranged around the inner wall and at the bottom are YFC and YFD respectively. After the sample reagent tube is placed into the biological sample processing device, the pressure values ​​detected by the pressure sensors are JFC and JFD respectively.

[0015] If the pressure values ​​detected in the four directions are JFC1=JFC2=JFC3=JFC4, it means that the sample reagent tube is not skewed; otherwise, it is determined that the sample reagent tube is skewed, and a reagent tube placement adjustment signal is generated, and the sample reagent tube placement adjustment signal is transmitted to the biological sample processing device of the biological detection system; if JFC1=JFC2=JFC3=JFC4 and JFD=YFD, it is determined that the sample reagent tube is stably placed; if JFC1=JFC2=JFC3=JFC4 and JFD≠YFD, it is determined that the amount of sample inside the sample reagent tube is reduced.

[0016] As a preferred embodiment of the present invention, the position of the sample mark on the sample reagent tube placed in the biological sample processing device is monitored and analyzed, and the specific monitoring and analysis process is as follows:

[0017] The rubbing roller located below the pressure sensor in the biological sample processing device rolls around the outside of the sample reagent tube for one circle, and the shape of the sample mark is rubbed on the rubbing paper. Then, the position and angle of the rubbing pattern on the rubbing paper are calculated, and the maximum deviation angle of the rubbing paper is preset as JZD;

[0018] If there is a rubbing pattern on the rubbing paper, the angle between the bottom edge of the rubbing pattern and the horizontal line drawn from a point on the bottom edge is detected, and the detected angle is marked as JDC. The maximum deviation angle JZD is then compared with the detected angle JDC. If JDC≤JZD, it is determined that the mark information reading can be carried out normally. If JDC>JZD, it is determined that an angle deflection with an angle reading of JDC is required when reading the mark information. If there is no rubbing pattern on the rubbing paper, the camera in the biological sample processing device is used to take pictures of the front and back sides of the sample reagent tube, and then the picture is recognized. If the sample mark is recognized on the picture, it is determined that the sample mark posting position is wrong, and the rubbing position adjustment operation is performed. Otherwise, it is determined that the sample mark is lost, and the corresponding sample reagent tube is pushed out of the biological sample processing device. The display terminal of the biological detection system displays "sample mark lost" to remind the staff to re-post the sample mark.

[0019] As a preferred embodiment of the present invention, the monitoring and analysis of the firmness of the sample mark on the sample reagent tube is carried out, and the specific monitoring and analysis process is as follows:

[0020] The infrared distance sensor in the biological sample processing device detects the distance data between the sample mark and the sample mark, and compares the detected distance data JLC with the preset distance data SJL between the sample mark and the inner wall of the placement position;

[0021] If JLC = SJL, it is determined that the sample label is firmly pasted. If JLC < SJL, it is determined that the sample label is loosely pasted, and the sample label firming operation is performed.

[0022] As a preferred embodiment of the present invention, the monitoring and analysis of the clarity of the sample label on the sample reagent tube are as follows:

[0023] Take pictures of the four sides of the sample reagent tube through the camera in the biological sample processing device, then compare and splice the four pictures to obtain a complete sample label. Then measure the width data of the label identifiers in the sample label, record each measured width data one by one, and plot coordinate points in the binary coordinate system established by the measurement order and width data. Then connect the adjacent coordinate points, and then calculate the slope value of each connected line, and record the slope value as XL;

[0024] If the difference between the slope values XL corresponding to each adjacent connected line is the same, it is determined that the sample label on the sample reagent tube is clear and correct. Otherwise, it is determined that the sample label is blurred. If the sample reagent tube has not entered the processing step, the corresponding sample reagent tube is pushed out of the biological sample processing device, and the display terminal of the biological detection system displays "Sample label is blurred", reminding the staff to re-paste the sample label. If the sample reagent tube has entered the processing step, while pushing the sample reagent tube out of the biological sample processing device, the display terminal prompts "The sample label has changed and is blurred".

[0025] As a preferred embodiment of the present invention, the biological sample processing device includes a sample processing box, wherein a plurality of evenly distributed placement slots are arranged inside the sample processing box, a reagent tube body is arranged inside the placement slot, positioning slots are opened in three directions above the inner side wall of the placement slot, a positioning push rod is installed at the middle position inside the positioning slot, an extrusion block is installed at the end of the positioning push rod away from the inside of the positioning slot, a limiting frame is integrally formed on one side of the outer side wall of the extrusion block corresponding to the positioning slot, pressure sensors are installed at the middle positions of the outer side walls of the three extrusion blocks and at the middle position of the bottom surface of the placement slot, a rubbing outer slot is opened on the inner side wall of the placement slot near the bottom of the positioning slot, a rubbing inner slot is opened in the middle position inside the rubbing outer slot, an inner gear ring is integrally formed at the middle position of the inner side wall of the rubbing inner slot, and a sliding frame is slidably connected to the inside of the rubbing inner slot. The inner side of the sliding frame is rotatably connected to a rolling gear via a rotating shaft at a position corresponding to the inner gear ring, and a rubbing frame is installed at an outer wall of the sliding frame corresponding to the position of the rubbing outer groove via a rubbing push rod, and limiting rods are installed on the outer wall of the rubbing frame in four directions corresponding to the rubbing push rod; the inner side of the rubbing frame is rotatably connected to an extrusion roller via a rotating shaft, and a sliding frame 2 is integrally formed with one side of the outer wall of the sliding frame 1 through a connecting plate, and an adjustment frame is installed at the outer wall of the sliding frame 2 corresponding to the position of the rubbing outer groove, and a length push rod is installed on the upper and lower surfaces of the interior of the adjustment frame, and a telescopic bracket is installed at one end of the length push rod away from the adjustment frame, and a side of the outer wall of the telescopic bracket away from the length push rod is rotatably connected to an arc plate via a rotating seat, and a side of the outer wall of the telescopic bracket away from the arc plate is also rotatably connected to an angle push rod via a rotating seat.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] During the biological detection process, the positioning of the sample mark on the outside of the sample reagent tube is first monitored and analyzed, and the situation where the sample reagent tube is not placed stably and the sample mark information is read incorrectly is checked. When the sample reagent tube is placed abnormally, it is corrected by adjusting the positioning push rod in the corresponding direction. Then, the sample mark position is monitored and analyzed, and the situation where the sample mark information is read incorrectly due to the wrong mark posting position is checked. Then, the sample mark is monitored and analyzed for firmness, and the situation where the sample mark is misplaced and loose is checked. Finally, the sample mark clarity is monitored and analyzed to determine the cause of the inability to read or the reading error of the sample mark information, and correct the error in time to prevent the error from being discovered in time, resulting in waste of sample resources, delays in experimental progress, and affecting the progress and results of scientific research projects. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to facilitate understanding by those skilled in the art, the present invention is further described below with reference to the accompanying drawings.

[0029] Figure 1 It is a system flow chart of the present invention;

[0030] Figure 2 is a structural diagram of the biological sample processing device of the present invention;

[0031] Figure 3 It is the internal structure diagram of the placement tank of the present invention;

[0032] Figure 4 For the present invention Figure 3 A magnified structural diagram of part A;

[0033] Figure 5 For the present invention Figure 3 A magnified structural diagram of part B;

[0034] Figure 6 It is a structural diagram of the connecting plate of the present invention;

[0035] Figure 7 For the present invention Figure 6 The enlarged structure diagram of the C part;

[0036] In the figure: 1. sample processing box; 2. placement slot; 3. reagent tube body; 41. extrusion block; 42. pressure sensor; 43. positioning slot; 44. positioning push rod; 45. limit frame; 51. inner gear ring; 52. rubbing outer slot; 53. rubbing inner slot; 54. limit rod; 55. sliding frame 1; 56. rubbing push rod; 57. rubbing frame; 58. rolling gear; 59. extrusion roller; 61. connecting plate; 62. adjustment frame; 63. length push rod; 64. telescopic bracket; 65. rotating seat; 66. arc plate; 67. angle push rod. DETAILED DESCRIPTION

[0037] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0038] Example:

[0039] See also Figure 1-7 As shown, the biological sample processing device and the biological detection system include:

[0040] The sample processing tube positioning detection module is used to monitor and analyze the position and angle of the reagent tube containing the sample to be processed placed in the biological sample processing device, and monitor the pressure data generated after the sample reagent tube is placed through the pressure sensors arranged around the inner wall and the bottom at the sample reagent tube placement position in the biological sample processing device. After the sample reagent tube of the corresponding size is placed into the biological sample processing device, the pressure values ​​caused by the pressure sensors arranged around the inner wall and the bottom are YFC and YFD respectively. After the sample reagent tube is placed into the biological sample processing device, the pressure values ​​detected by the pressure sensors are JFC and JFD respectively.

[0041] If the pressure values ​​JFC1=JFC2=JFC3=JFC4 detected in the four directions, it means that the sample reagent tube is not skewed. Otherwise, it is determined that the sample reagent tube is skewed, and a reagent tube placement adjustment signal is generated. The sample reagent tube placement adjustment signal is transmitted to the biological sample processing device of the biological detection system. The pressure values ​​detected in the four directions are compared to determine that the reagent tube is skewed to the side with a larger pressure value. The signal can be transmitted to the positioning push rod 44 on the extrusion block 41 corresponding to the side with a larger pressure value through the sample processing tube positioning detection module. The positioning push rod 4 4 extends to push the extrusion block 41 outward to straighten the crooked reagent tube; if JFC1=JFC2=JFC3=JFC4 and JFD=YFD, it is determined that the sample reagent tube is stably placed; if JFC1=JFC2=JFC3=JFC4 and JFD≠YFD, it is determined that the sample amount inside the sample reagent tube is reduced, and the sample amount data inside the sample reagent tube in the previous operation process of the sample processing is retrieved; if the two are different, it is determined that the current sample processing operation causes the sample amount to be reduced; otherwise, the sample amount data inside the sample reagent tube in the previous operation process is retrieved and compared;

[0042] The sample mark position detection module is used to monitor and analyze the position of the sample mark on the sample reagent tube placed in the biological sample processing device. The rubbing roller located below the pressure sensor in the biological sample processing device rolls around the outer side of the sample reagent tube for one circle, and the shape of the sample mark is rubbed on the rubbing paper. The position and angle of the rubbing pattern on the rubbing paper are then calculated, and the maximum deviation angle of the rubbing paper is preset to JZD;

[0043] If there is a rubbing pattern on the rubbing paper, the angle between the bottom edge of the rubbing pattern and the horizontal line drawn from a point on the bottom edge is detected, and the detected angle is marked as JDC. The maximum deviation angle JZD is then compared with the detected angle JDC. If JDC≤JZD, it is determined that the mark information reading can be carried out normally. If JDC>JZD, it is determined that an angle deflection with an angle reading of JDC is required when reading the mark information. If there is no rubbing pattern on the rubbing paper, the camera in the biological sample processing device is used to take pictures of the front and back sides of the sample reagent tube, and then the picture is recognized. If the sample mark is recognized on the picture, it is determined that the sample mark is posted in an incorrect position, and the rubbing position adjustment operation is performed. After the marking position on the sheet is proportionally enlarged to the same depth as the placement slot 2, the vertical height between the sample mark and the bottom surface of the placement slot 2 is calculated, and then the spacing between the sample mark and the rubbing outer slot 52 is calculated, and the calculated spacing data between the sample mark and the rubbing outer slot 52 is transmitted to the lifting push rod at the bottom of the placement slot 2, so that the lifting push rod is adjusted in length, and the sample mark is moved to the corresponding rubbing outer slot 52 position. The lifting push rod is reset after the squeezing roller 59 completes the rubbing operation. Otherwise, it is determined that the sample mark is lost, and the corresponding sample reagent tube is pushed out of the biological sample processing device. The display terminal of the biological detection system displays "sample mark is lost" to remind the staff to re-post the sample mark;

[0044] Sample Mark Firmness Detection Module, which is used to monitor and analyze the firmness of the sample mark posted on the sample reagent tube. It detects the distance data between the infrared distance sensor in the biological sample processing device and the sample mark, and compares the detected distance data JLC with the preset distance data SJL between the sample mark and the inner wall of the placement position. If JLC = SJL, it is determined that the sample mark is firmly pasted. If JLC < SJL, it is determined that the sample mark is loosely pasted, and the sample mark firmness operation is executed. The second sliding frame rotates inside the rubbing groove 53 driven by the driving motor on the first sliding frame 55. After the second sliding frame moves to the sample mark position, the position where JLC < SJL is the loose mark. Then, by calculating the number of rotation turns of the driving motor and the outer diameter data of the rolling gear 58, the length push rod 63 on the second sliding frame is aligned with the loose mark position. According to the height data, width data, and position data of the mark position, the distance data between the upper and lower ends of the loose mark and the sample mark is calculated. If both the upper and lower ends of the sample mark are loose, the lengths of the upper and lower length push rods 63 on the adjustment frame 62 are adjusted. One end of the arc-shaped plate 66 is aligned with the loose mark position for loosening operation. If only one end is loose, according to the distance data between the upper and lower ends of the loose mark and the sample mark, the end with the smaller distance data is selected for loosening operation. By calculating the difference between JLC and SJL, the height data of the loose protrusion can be obtained. Then, the length of the angle push rod 67 is shortened to gradually bring one end of the arc-shaped plate 66 closer to the outer wall of the reagent tube body 3, and the length of the telescopic support 64 is shortened synchronously. When the distance between one end of the arc-shaped plate 66 and the outer wall of the reagent tube body 3 is smaller than the height of the loose protrusion, the length push rod 63 extends to insert one end of the arc-shaped plate 66 into the loose position of the sample mark. After the insertion length of the arc-shaped plate 66 reaches the length of the loose mark, the angle push rod 67 extends to push the arc-shaped plate 66 to rotate and open around the rotating seat 65 on the telescopic support 64, and at the same time, the length of the telescopic support 64 extends to push the sample mark to move outward and become loose. After loosening, the telescopic support 64 and the angle push rod 67 are shortened again, and then the length push rod 63 extends for propulsion. Repeat the above operations until the sample mark at the entire loose mark position is separated from the outer wall of the reagent tube body 3. Then, the driving motor drives the rubbing frame 57 and the adjustment frame 62 as a whole to move, and displace towards the side with the shorter distance between the loose mark and the two sides. After one side of the sample mark is completely separated from the outer wall of the reagent tube body 3, the continuously rotating extrusion roller 59 can reattach the loosened sample mark to the outer wall of the reagent tube body 3, so that the sample mark is completely posted on the outside of the reagent tube body 3;

[0045] The sample mark clarity detection module is used to monitor and analyze the clarity of the sample mark on the sample reagent tube. The camera in the biological sample processing device takes pictures around the sample reagent tube, and then compares and splices the four pictures to obtain a complete sample mark. Then the width data of the mark mark in the sample mark is measured, and each width data obtained by the measurement is recorded one by one, and the coordinate points are drawn in the binary coordinate system established by the measurement sequence and the width data, and then the adjacent coordinate points are connected, and the slope of each connecting line is calculated, and the slope value is recorded as XL;

[0046] If the difference between the slope values ​​XL corresponding to each adjacent segment of the connecting line is the same, it is determined that the sample mark on the sample reagent tube is clear and correct. Otherwise, it is determined that the sample mark is blurred. If the sample reagent tube has not entered the processing step, the corresponding sample reagent tube is pushed out of the biological sample processing device, and the display terminal of the biological detection system displays "the sample mark is blurred" to remind the staff to re-post the sample mark. If the sample reagent tube has entered the processing step, the display terminal prompts "the sample mark has changed and is blurred" while the sample reagent tube is pushed out of the biological sample processing device.

[0047] The sample label information reading module is used to read the sample label information on the sample reagent tube, and compare and analyze the sample read information with the previously recorded sample information. If the two types of sample information are compared correctly, the biological sample processing operation continues to be executed, otherwise, the biological sample processing operation stops.

[0048] The biological sample processing device includes a sample processing box 1, wherein a plurality of evenly distributed placement slots 2 are arranged inside the sample processing box 1, a reagent tube body 3 is arranged inside the placement slot 2, positioning slots 43 are opened in three directions above the inner side wall of the placement slot 2, a positioning push rod 44 is installed at the middle position inside the positioning slot 43, an extrusion block 41 is installed at one end of the positioning push rod 44 away from the inside of the positioning slot 43, the outer side of the extrusion block 41 is designed to be arc-shaped, and the size of the arc is the same as the arc size of the placement slot 2, and a limiting frame 45 is integrally formed on one side of the outer side wall of the extrusion block 41 corresponding to the positioning slot 43, and the size of the limiting frame 45 is consistent with the size of the positioning slot 43, so that the limiting frame 45 is more stable when sliding inside the positioning slot 43, and will not shake. A pressure sensor 42 is installed at the middle position of the outer wall of the extrusion block 41 and the middle position of the bottom surface of the placement groove 2. A rubbing outer groove 52 is opened on the inner wall of the placement groove 2 near the bottom of the positioning groove 43. A rubbing inner groove 53 is opened in the middle position of the rubbing outer groove 52. The height of the rubbing inner groove 53 is smaller than the height of the rubbing outer groove 52. An inner gear ring 51 is integrally formed at the middle position of the inner wall of the rubbing inner groove 53. The rolling gear 58 and the inner gear ring 51 are on the same plane, and the two are embedded with each other, so that the rolling gear 58 can drive the sliding frame 1 55 to rotate around the inner gear ring 51 inside the rubbing inner groove 53 when rotating. The inside of the rubbing inner groove 53 is slidably connected with a sliding frame 1 55, and the inner side of the sliding frame 1 55 corresponds to the position of the inner gear ring 51 A rolling gear 58 is rotatably connected to the sliding frame 1 55 through a rotating shaft, a driving motor is installed at the rotating shaft position of the rolling gear 58 on the upper surface of the sliding frame 1 55, a rubbing frame 57 is installed at the position of the rubbing outer groove 52 corresponding to the outer wall of the sliding frame 1 55 through a rubbing push rod 56, the spacing between the rubbing frame 57 and the sliding frame 1 55 is adjusted by the rubbing push rod 56, and a limiting rod 54 is installed on the four directions of the outer wall of the rubbing frame 57 corresponding to the rubbing push rod 56, and an extrusion roller 59 is rotatably connected to the inner side of the rubbing frame 57 through a rotating shaft, and a sliding frame 2 is integrally formed with the outer wall of the sliding frame 1 55 through a connecting plate 61. The structure of the sliding frame 2 is the same as that of the sliding frame 1 55, and the outer wall of the sliding frame 2 corresponds to the outer groove 52 of the rubbing. An adjustment frame 62 is installed at the position, and length push rods 63 are installed on the upper and lower surfaces of the interior of the adjustment frame 62. A telescopic bracket 64 is installed at the end of the length push rod 63 away from the adjustment frame 62, and the length of the telescopic bracket 64 can be adjusted. The side of the outer wall of the telescopic bracket 64 away from the length push rod 63 is rotatably connected to an arc plate 66 through a rotating seat 65. The arc plate 66 is a conical structure, and a number of spherical protrusions are evenly distributed on the outer wall of the arc plate 66 to reduce the contact area between the arc plate 66 and the sample mark. The side of the outer wall of the telescopic bracket 64 away from the arc plate 66 is also rotatably connected to an angle push rod 67 through a rotating seat 65. The two ends of the angle push rod 67 are rotatably connected to the telescopic bracket 64 and the arc plate 66 through the rotating seat 65 respectively.

[0049] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to only specific implementation methods. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A biological detection system, characterized in that include: The sample processing tube positioning detection module is used to monitor and analyze the position and angle of the reagent tube containing the sample to be processed placed in the biological sample processing device. If the reagent tube is placed in the correct position, the sample marking position detection module is executed, otherwise, the reagent tube position adjustment operation is executed; the specific monitoring and analysis process of monitoring and analyzing the position and angle of the reagent tube containing the sample to be processed placed in the biological sample processing device is as follows: The pressure data generated after the sample reagent tube is placed is monitored by the pressure sensors arranged around the inner wall and at the bottom of the sample reagent tube placement position in the biological sample processing device. After the sample reagent tube of a preset corresponding size is placed into the biological sample processing device, the pressure values ​​caused by the pressure sensors arranged around the inner wall and at the bottom are YFC and YFD respectively. After the sample reagent tube is placed into the biological sample processing device, the pressure values ​​detected by the pressure sensors are JFC and JFD respectively. If the pressure values ​​JFC1=JFC2=JFC3=JFC4 detected in the four directions, it means that the sample reagent tube is not skewed. Otherwise, it is determined that the sample reagent tube is skewed, and a reagent tube placement adjustment signal is generated, and the sample reagent tube placement adjustment signal is transmitted to the biological sample processing device of the biological detection system; If JFC1=JFC2=JFC3=JFC4 and JFD=YFD, it is determined that the sample reagent tube is placed stably; if JFC1=JFC2=JFC3=JFC4 and JFD≠YFD, it is determined that the amount of sample inside the sample reagent tube is reduced; The sample mark position detection module is used to monitor and analyze the position of the sample mark on the sample reagent tube placed in the biological sample processing device. If the position of the sample mark on the sample reagent tube is correct, the sample mark firmness detection module is executed, otherwise, the rubbing position adjustment operation is executed; The sample mark firmness detection module is used to monitor and analyze the firmness of the sample mark on the sample reagent tube. If the sample mark on the sample reagent tube is firmly posted, the sample mark clarity detection module is executed, otherwise, the sample mark firmness operation is executed; The sample mark clarity detection module is used to monitor and analyze the clarity of the sample mark on the sample reagent tube. If the sample mark on the sample reagent tube is clear and correct, the sample mark information reading module is executed, otherwise, the sample mark replacement operation is executed; The sample label information reading module is used to read the sample label information on the sample reagent tube, and compare and analyze the sample read information with the previously recorded sample information. If the two types of sample information are compared correctly, the biological sample processing operation continues to be executed, otherwise, the biological sample processing operation stops; The monitoring and analysis of the position of the sample mark on the sample reagent tube placed in the biological sample processing device is performed, and the specific monitoring and analysis process is as follows: The rubbing roller located below the pressure sensor in the biological sample processing device rolls around the outer side of the sample reagent tube for one week to rub the shape of the sample mark on the rubbing paper. Then, the position and angle of the rubbed pattern on the rubbing paper are calculated. The maximum deviation angle of the rubbing paper is preset as JZD; If there is a rubbed pattern on the rubbing paper, the included angle between the bottom edge of the rubbed pattern and the horizontal line made from a point on the bottom edge is detected, and the detected included angle is marked as JDC. Then, the maximum deviation angle JZD is compared with the detected included angle JDC. If JDC ≤ JZD, it is determined that the mark information reading can be carried out normally. If JDC > JZD, it is determined that an angle deflection with an angle reading of JDC is required during the mark information reading. If there is no rubbed pattern on the rubbing paper, pictures of the front and back sides of the sample reagent tube are taken through the camera in the biological sample processing device. Then, the pictures are identified. If the sample mark is identified on the picture, it is determined that the posting position of the sample mark is incorrect, and the rubbing position adjustment operation is executed. Otherwise, it is determined that the sample mark is lost, and the corresponding sample reagent tube is pushed out of the biological sample processing device, and the display terminal of the biological detection system displays "Sample mark lost", reminding the staff to re-post the sample mark.

2. The biological detection system according to claim 1, characterized in that: The monitoring and analysis of the posting firmness of the sample mark on the sample reagent tube are as follows: The distance data between the sample mark is detected by the infrared distance sensor in the biological sample processing device, and the detected distance data JLC is compared with the preset distance data SJL between the sample mark and the inner wall of the placement position; If JLC = SJL, it is determined that the sample mark is firmly pasted. If JLC < SJL, it is determined that the sample mark is loosely pasted, and the sample mark firmness operation is executed.

3. The biological detection system according to claim 1, characterized in that: The monitoring and analysis of the clarity of the sample mark on the sample reagent tube are as follows: Pictures around the sample reagent tube are taken through the camera in the biological sample processing device. Then, the four pictures are compared and spliced to obtain a complete sample mark. Then, the width data of the mark identification in the sample mark is measured, and each measured width data is recorded one by one. Coordinate points are plotted in the binary coordinate system established by the measurement sequence and the width data. Then, the adjacent coordinate points are connected, and the slope value of each connected line is calculated, and the slope value is recorded as XL; If the difference between the slope values XL corresponding to each adjacent connected line is the same, it is determined that the sample mark on the sample reagent tube is clear and correct. Otherwise, it is determined that the sample mark is blurred. If the sample reagent tube has not entered the processing step, the corresponding sample reagent tube is pushed out of the biological sample processing device, and the display terminal of the biological detection system displays "Sample mark blurred", reminding the staff to re-post the sample mark. If the sample reagent tube has entered the processing step, while the sample reagent tube is pushed out of the biological sample processing device, the display terminal prompts "The sample mark has changed and is blurred".

4. A biological sample processing device of a biological detection system as claimed in claim 1, characterized in that: The biological sample processing device comprises a sample processing box (1), wherein a plurality of evenly distributed placement slots (2) are arranged inside the sample processing box (1), a reagent tube body (3) is arranged inside the placement slot (2), positioning slots (43) are opened in three directions above the inner side wall of the placement slot (2), a positioning push rod (44) is installed at the middle position inside the positioning slot (43), an extrusion block (41) is installed at one end of the positioning push rod (44) away from the inside of the positioning slot (43), and the outer side wall of the extrusion block (41) is integrally formed with a side corresponding to the positioning slot (43). A limiting frame (45) is provided, pressure sensors (42) are installed at the middle positions of the outer walls of the three extrusion blocks (41) and at the middle position of the bottom surface of the placement groove (2), an outer rubbing groove (52) is provided on the inner wall of the placement groove (2) near the bottom of the positioning groove (43), an inner rubbing groove (53) is provided at the middle position inside the outer rubbing groove (52), an inner gear ring (51) is integrally formed at the middle position of the inner wall of the inner rubbing groove (53), a sliding frame (55) is slidably connected inside the inner rubbing groove (53), and the inner side of the sliding frame (55) corresponds to A rolling gear (58) is rotatably connected to the position of the inner gear ring (51) via a rotating shaft; a rubbing frame (57) is installed at a position of the outer wall of the sliding frame 1 (55) corresponding to the rubbing outer groove (52) via a rubbing push rod (56); limiting rods (54) are installed on the outer wall of the rubbing frame (57) in four directions corresponding to the rubbing push rod (56); an extrusion roller (59) is rotatably connected to the inner side of the rubbing frame (57) via a rotating shaft; a sliding frame 2 is integrally formed on one side of the outer wall of the sliding frame 1 (55) via a connecting plate (61); and the outer wall of the sliding frame 2 is An adjustment frame (62) is installed at a position corresponding to the rubbing outer groove (52), and length push rods (63) are installed on the upper and lower surfaces of the interior of the adjustment frame (62). A telescopic bracket (64) is installed at one end of the length push rod (63) away from the adjustment frame (62), and a side of the outer wall of the telescopic bracket (64) away from the length push rod (63) is rotatably connected to an arc plate (66) via a rotating seat (65), and a side of the outer wall of the telescopic bracket (64) away from the arc plate (66) is also rotatably connected to an angle push rod (67) via a rotating seat (65).

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