A composition for soothing liver and relieving depression, a paste formula, a preparation method and application

Abstract

The application provides a composition for soothing liver and relieving depression, a paste prescription, a preparation method and application, and belongs to the paste prescription field.The composition for soothing liver and relieving depression is composed of the following components in parts by mass: 15-25 parts of oyster, 10-20 parts of cassia seed, 10-20 parts of lily, 7-17 parts of loquat leaf, 7-17 parts of hawthorn, 5-15 parts of perilla leaf, 5-15 parts of rose flower, 5-15 parts of day day flower, 5-15 parts of citrus medica, 6-10 parts of raphanus sativus, 4-8 parts of gardenia and 4-8 parts of tangerine peel.The paste prescription prepared from the composition has the effect of relieving anxiety and depression caused by liver qi stagnation.The application also provides a preparation method of the paste prescription for soothing liver and relieving depression.The paste prescription prepared by the method has the characteristics of good taste and stable quality, and has a good application prospect.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of paste, and relates to a composition for soothing liver and relieving depression, a paste, a preparation method and application. BACKGROUND

[0002] In modern life, people often face various pressures, such as work pressure, academic pressure, interpersonal relationship problems, etc. These pressures and the anxiety they bring can have a negative impact on physical and mental health. Traditional Chinese medicine believes that "liver likes to be smooth and dislikes depression", and liver depression and stagnation is related to emotional depression. Symptoms of liver stagnation include: chest tightness and pain; depression, poor mental state; loss of appetite, stomach distension and belching; phlegm cough; female breast swelling, irregular menstruation. Therefore, traditional Chinese medicine products with the functions of soothing liver and relieving depression and relieving anxiety are very meaningful in modern society.

[0003] Patent CN110123994A discloses a traditional Chinese medicine composition for improving qi depression constitution, bergamot mint paste and a preparation method. The traditional Chinese medicine composition is prepared from the following raw materials: bergamot 0.7-4.5 parts, poria 2.5-7.5 parts, longan meat 0.5-1.2 parts, ginger 0.7-2 parts, mint 0.4-1.2 parts, and malt 0.7-2 parts. However, the disclosure fails to provide a traditional Chinese medicine paste with good taste and stable quality to achieve better liver-soothing and depression-relieving effects.

[0004] Patent CN114010693A discloses a medicine composition for soothing liver and relieving depression, a preparation method and application thereof. The medicine composition contains gamma-aminobutyric acid and three-flower bergamot extract (rose, chrysanthemum, daye flower, bergamot). The composition has the effects of soothing liver and relieving depression, relieving symptoms such as lack of pleasure and helplessness, and can also reduce liver fat lesions caused by non-alcoholic fatty liver and improve liver function. However, the disclosure fails to provide a traditional Chinese medicine paste with good taste and stable quality to achieve better liver-soothing and depression-relieving effects.

[0005] Patent CN115364164A discloses a traditional Chinese medicine composition for treating liver depression type insomnia, which is prepared from the following raw materials: groundnut branches and leaves 6-30 parts, and prepared cyperus rotundus 6-30 parts. The groundnut branches and leaves can calm the liver and soothe the nerves, and the cyperus rotundus can soothe the liver and relieve depression. The combination of the two can strengthen the effects of soothing liver and regulating qi and the efficacy of calming the mind and sleeping. However, the disclosure fails to provide a traditional Chinese medicine paste with good taste and stable quality to achieve better liver-soothing and depression-relieving effects.

[0006] Concha Ostreae, the dry shell of a kind of shellfish, is the base of the traditional Chinese medicine. The shell is usually in the shape of long flake or circle, oval or triangle, with layered and hard scales. The outer shell is light purple, grey or yellowish brown, and the inner shell is usually white. The calcium carbonate content in Concha Ostreae is more than 90%, and it also contains magnesium, sodium, strontium, iron, aluminum, silicon, titanium, manganese, copper, potassium, zinc, phosphorus, sulfur and other elements, as well as proteins. Pharmacology shows that Concha Ostreae has the effects of enhancing immunity, calming, and resisting gastric ulcer, etc.

[0007] Semen Cassiae, mainly produced in Jiangsu, Anhui, Sichuan and other places, is the mature seeds of Cassia obtusifolia L. The seeds are slightly rhombic or short cylindrical, with both ends parallel and inclined, 3-7 mm long and 2-4 mm wide. The surface is greenish brown or dark brown, smooth and shiny. It has a slight smell and a bitter taste. Semen Cassiae contains quinone compounds such as chrysophanol, physcion, obtusifolin, chryso-obtusin, obtusin, aurantio-obtusin, gluco-obtusifolin, rubrofusarin, cassiaside, torosa-chrysone, isotoralactone, cassialactone, 1,3-dihydroxy-6-methoxy-7-methyl anthraquinone, and alaternin-1-O-β-D-glucopyranoside, etc. It also contains fatty acids such as palmitic acid, stearic acid, oleic acid, and linoleic acid, as well as volatile oil substances such as dihydroactinodiolide, m-cresol, 2-hydroxy-4-methody-acetophenone, methyl palmitate, and sterol substances such as cholesterol, stigmasterol, and β-sitosterol. Pharmacology shows that Semen Cassiae has the effects of resisting bacteria, resisting fungi, reducing blood pressure, reducing blood lipids, resisting platelet aggregation, etc.

[0008] Lilium brownii var. viridulum, mainly produced in Hebei, Henan, Anhui, Jiangxi, Zhejiang, Hubei, Hunan, Shaanxi, etc. Its medicinal ingredient is bulb. The scale leaf of Lilium brownii var. viridulum is long elliptical, 2-5 cm long, 1-2 cm wide, 1.3-4 mm thick in the middle. The surface is white, light brownish yellow or slightly purple. There are several longitudinal parallel white vascular bundles. The quality is hard and brittle, the cross section is relatively flat, and the surface is horny. It has no odor and slightly bitter taste. The bulb of Lilium brownii var. viridulum contains saponins, such as regaloside A, regaloside D, 3,6'-O-diferuloylsucrose, 26-O-β-D-glucopyranosyl-nuatigenin-3-O-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside, solasodine-3-O-α-L-rhamnopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-β-D-glucopyranoside, etc. It also contains 1-O-feruloylglycerol, 1-O-p-coumaroylglycerol, and β1-solamargine, etc. Pharmacology shows that Lilium brownii var. viridulum has the effects of relieving cough, asthma and phlegm, resisting stress injury, sedation and hypnosis, improving immunity, reducing blood sugar, and resisting oxidation.

[0009]

[0010] ​Folium Eriobotryae is mainly produced in East China, Central South, Southwest, and Shaanxi, Gansu, etc. The leaf is long oval or inversely ovate, 12-30 cm long, 4-9 cm wide. The tip is sharp, the base is wedge-shaped, and the upper edge is sparsely serrated. The upper surface is gray-green, yellow-brown or red-brown, and relatively smooth; the lower surface is light gray or brown-green, densely covered with yellow fluff, and the main vein is prominent on the lower surface. The gas is slightly bitter. Folium Eriobotryae mainly contains amygdalin; organic acids such as tartaric acid, citric acid, malic acid; triterpenoids such as oleanolic acid, ursolic acid, maslinic acid, euscaphic acid, eriobofuran, loguatifolin A, hyperoside, etc. Pharmacology shows that Folium Eriobotryae has the effects of expectorant, antitussive, antiasthmatic, anti-inflammatory, etc.

[0011] Fructus Crataegi is mainly produced in Henan, Shandong, Hebei, etc. The fruit of Fructus Crataegi is similar to a sphere, 1-3 cm in diameter, with a shiny surface, covered with gray-white spots, with a persistent calyx at the top and a fruit stalk scar at the base. The flesh is thick and hard, with a slight fragrance, a sour and slightly sweet taste. The fruit of Fructus Crataegi contains flavonoids such as epi-catechin, quercetin, hyperoside, flavan polymers, vitexin rhamnoside, and chlorogenic acid, ursolic acid, api-genin-8-C-(6"-acetyl)-β-D-glucopyranoside, etc. Pharmacology shows that Fructus Crataegi has the effects of promoting digestion, lowering blood lipids, lowering blood pressure, antioxidant and improving immunity, etc.

[0012] The paste is an important dosage form of traditional Chinese medicine, which has the characteristics of convenient carrying and eating, without additional preparation and processing. However, the prior art cannot provide a traditional Chinese medicine paste with good taste and stable quality to achieve better liver-soothing and depression-relieving and anxiety-relieving effects. SUMMARY

[0013] Therefore, in view of the problem that the prior art cannot provide a traditional Chinese medicine paste with good taste and stable quality to achieve better liver-soothing and depression-relieving effects, the purpose of the present application is to provide a liver-soothing and depression-relieving composition, paste, preparation method and application.

[0014] To achieve the above object, in one aspect, the present application provides a composition for soothing liver and relieving depression, which is composed of the following components in parts by mass: 15-25 parts of oyster shell, 10-20 parts of cassia seed, 10-20 parts of lily, 7-17 parts of loquat leaf, 7-17 parts of hawthorn, 5-15 parts of perilla leaf, 5-15 parts of rose flower, 5-15 parts of day day flower, 5-15 parts of citrus medica, 6-10 parts of raphanus sativus, 4-8 parts of gardenia and 4-8 parts of dried tangerine or orange peel.

[0015] Preferably, the composition is composed of the following components in parts by mass: 18-22 parts of oyster shell, 13-17 parts of cassia seed, 13-17 parts of lily, 9-15 parts of loquat leaf, 9-15 parts of hawthorn, 8-12 parts of perilla leaf, 8-12 parts of rose flower, 8-12 parts of day day flower, 8-12 parts of citrus medica, 7-9 parts of raphanus sativus, 5-7 parts of gardenia and 5-7 parts of dried tangerine or orange peel.

[0016] More preferably, the composition is composed of the following components in parts by mass: 20 parts of oyster shell, 15 parts of cassia seed, 15 parts of lily, 12 parts of loquat leaf, 12 parts of hawthorn, 10 parts of perilla leaf, 10 parts of rose flower, 10 parts of day day flower, 10 parts of citrus medica, 8 parts of raphanus sativus, 6 parts of gardenia and 6 parts of dried tangerine or orange peel.

[0017] Preferably, the mass ratio of the rose flower to the day day flower is 1:1.

[0018] Preferably, the mass ratio of the perilla leaf to the citrus medica is 1:1.

[0019] Preferably, and as an example of the present application, the rose flower is the dried flower bud of double rose.

[0020] Preferably, and as an example of the present application, the dried tangerine or orange peel is broad tangerine or orange peel.

[0021] In another aspect, the present application provides a preparation method of the above composition, which comprises the following steps:

[0022] Mixing oyster shell, cassia seed, lily, loquat leaf, hawthorn, perilla leaf, rose flower, day day flower, citrus medica, raphanus sativus, gardenia and dried tangerine or orange peel with water, decocting, filtering, collecting the filtrate, concentrating to obtain a concentrated solution.

[0023] Preferably, the oyster shell is pretreated before decocting.

[0024] More preferably, the pretreatment comprises washing, crushing and drying.

[0025] More preferably, the crushing is crushing into pieces with a weight of 2-20 g each.

[0026] Preferably, the decocting is decocting for 2-3 times, adding 6-8 times mass of water each time, and decocting for 5-8 hours.

[0027] More preferably, and as an example of the present application, the decocting is decocting 3 times, each time with 7 times the mass of water, for 7 hours.

[0028] Preferably, the concentration is to a density of 1.20-1.40 g / mL.

[0029] More preferably, and as an example of the present application, the concentration is to a density of 1.33 g / mL.

[0030] In still another aspect, the present application provides a liver-soothing and depression-relieving medicament, characterized in that the raw material is the above-mentioned composition and / or the composition prepared by the above-mentioned preparation method.

[0031] The medicament can be prepared into dosage forms for administration such as pills, capsules, granules, oral solutions, powders, tablets, lozenges, and sugar-coated tablets, and suitable pharmaceutical carriers can be selected according to different dosage forms.

[0032] The pharmaceutical carriers used can be solid, liquid, or gas. Examples of solid carriers include lactose, kaolin, sucrose, talc, gelatin, agar, pectin, acacia, magnesium stearate, and stearic acid. Examples of liquid carriers include sugar syrup, peanut oil, olive oil, and water. Examples of gaseous carriers include carbon dioxide and nitrogen.

[0033] In preparing the compositions in oral dosage forms, any convenient pharmaceutical media can be used. For example, water, ethanol, oils, alcohols, flavoring agents, preservatives, coloring agents, and the like can be used to form oral liquid preparations such as suspensions, emulsions, and solutions; and carriers such as starches, sugars, microcrystalline cellulose, diluents, granulating agents, emulsifying agents, lubricants, binders, disintegrating agents can be used to form oral solid preparations such as powders, capsules, and tablets. Tablets and capsules are preferred oral dosage units for use with solid pharmaceutical carriers because of their ease of administration. Coating agents can be used to coat tablets and capsules using standard aqueous or non-aqueous techniques.

[0034] Tablets containing the herbal composition of the present application can be prepared by compression or molding, optionally, with one or more accessory ingredients or adjuvants. Compressed tablets can be prepared by compressing in a free-flowing form such as a powder or granules, optionally mixed with a binder, lubricant, inert diluent, surface active or dispersing agent. Molded tablets can be made by molding in a suitable machine a mixture of the powdered compound moistened with a liquid diluent. Each tablet preferably contains from about 0.05 mg to about 5 g of the active ingredient. Each cachet or capsule preferably contains from about 0.05 mg to about 5 g of the active ingredient. For instance, a formulation intended to be administered to the human subject orally can contain from about 0.5 mg to about 5 g of active drug substance compounded with an appropriate and convenient amount of a carrier material which can take a form of tablets, pills, capsules, cachets, etc. Unit dosages will generally contain between about 1 mg and about 2 g, often about 25 mg, 50 mg, 100 mg, 200 mg, 300 mg, 400 mg, 500 mg, 600 mg, 800 mg or 1000 mg of the active ingredient.

[0035] The pharmaceutical compositions of this application suitable for parenteral administration can be formulated as solutions or suspensions of the active compounds in either aqueous or non-aqueous liquids, such as glycols, oils, and the like. The pharmaceutical compositions can include suitable surfactants, such as hydroxypropylcellulose. Dispersions can also be prepared in glycerol, liquid polyethylene glycols, and the like. Additionally, preservatives can be added to prevent the growth of microorganisms.

[0036] The pharmaceutical compositions of this application can be in a form suitable for topical use, such as an aerosol, cream, ointment, lotion, powder, or the like. Additionally, the compositions can be in a form suitable for transdermal administration. These preparations can be transdermal patches or the like. The herbal composition of the present application can be used in conventional techniques to prepare such formulations. For example, creams or ointments can be prepared by mixing the herbal composition of the present application with a carrier, such as the hydrophilic material and water, and about 5% to about 10% by weight of the compound.

[0037] The pharmaceutical compositions of this application can be in a form suitable for topical use, such as an aerosol, cream, ointment, lotion, powder, or the like. Additionally, the compositions can be in a form suitable for transdermal administration. These preparations can be transdermal patches or the like. The herbal composition of the present application can be used in conventional techniques to prepare such formulations. For example, creams or ointments can be prepared by mixing the herbal composition of the present application with a carrier, such as the hydrophilic material and water, and about 5% to about 10% by weight of the compound.

[0038] In addition to the carrier ingredients, the pharmaceutical formulations described above can include, as appropriate, one or more of the following: diluents, buffers, flavoring agents, binders, surface active agents, thickeners, lubricants, preservatives (including antioxidants), colorants, and the like. Additional excipients can be added, such as lactose, starch, cellulose derivatives, magnesium stearate, stearic acid, and the like, coloring agents and flavoring agents. The formulations are provided in a form suitable to practice the method described herein. For example, the formulations can be provided in unit dosage form, e.g., in the form of tablets or capsules. The formulations can be prepared using conventional techniques.

[0039] Preferably, the medicine further comprises a pharmaceutically acceptable excipient.

[0040] More preferably, the pharmaceutically acceptable excipient comprises at least one of diluent, excipient, filler, binder, humectant, lubricant, disintegrant, absorption promoter, surfactant, adsorption carrier, and flavoring agent, sweetener.

[0041] Preferably, the dosage form of the medicine is selected from pill, capsule, granule, oral liquid, powder, tablet, lozenge, syrup.

[0042] In another aspect, the present application provides a paste formula for soothing liver and relieving depression, which is made of raw materials and excipients, wherein the raw materials are the above-mentioned composition, and the excipients are at least one of isomaltooligosaccharide, isomaltulose, rock candy, and honey.

[0043] Preferably, and as an example of the present application, in the paste formula, the excipient is isomaltooligosaccharide.

[0044] In another aspect, the present application provides a preparation process of the above-mentioned paste formula, which comprises the following steps:

[0045] T1, mix oyster, cassia seed, lily, loquat leaf, hawthorn, perilla leaf, rose flower, daye flower, citron, raphanus, gardenia, and dried tangerine peel with water, decoct, filter, collect the filtrate, concentrate, and obtain a concentrated solution;

[0046] T2, mix the concentrated solution prepared in step T1 with excipients, stir and concentrate, and obtain a paste formula.

[0047] Preferably, in step T1, the oyster is pretreated before decoction.

[0048] More preferably, the pretreatment comprises washing, crushing, and drying.

[0049] More preferably, the crushing is crushing into pieces with a weight of 2-20 g per piece.

[0050] Preferably, in step T1, the decoction is decocting for 2-3 times, and 6-8 times the mass of water is added each time for decoction for 5-8 hours.

[0051] More preferably, and as an example of the present application, in step T1, the decoction is decocting for 3 times, and 7 times the mass of water is added each time for decoction for 7 hours.

[0052] Preferably, in step T1, the concentration is concentrating to a density of 1.20-1.40 g / mL.

[0053] More preferably, and as an example of the present application, in step T1, the concentration is concentrating to a density of 1.20 g / mL.

[0054] Preferably, in step T2, the volume to mass ratio of the concentrated solution to the adjuvant is 20-40 mL: 55-85 g.

[0055] More preferably, in step T2, the volume to mass ratio of the concentrated solution to the adjuvant is 25-35 mL: 60-80 g.

[0056] Still more preferably, and as an example of the present application, in step T2, the volume to mass ratio of the concentrated solution to the adjuvant is 30 mL: 70 g.

[0057] Preferably, in step T2, the concentration is performed at 40-60℃ to a density of 1.41-1.65 g / mL.

[0058] More preferably, and as an example of the present application, in step T2, the concentration is performed at 50℃ to a density of 1.60 g / mL.

[0059] In another aspect, the present application also provides use of the above-mentioned composition, the preparation method of the composition, the medicine, the paste, and the preparation process of the paste in preparation of a liver-soothing and depression-relieving product.

[0060] The product includes, but is not limited to, a paste, a traditional Chinese medicine, a food, a health product, a product with the same origin of medicine and food, etc.

[0061] Preferably, the product includes a paste with the same origin of medicine and food, a traditional Chinese medicine, and a food.

[0062] The traditional Chinese medicine components used in the present application are further explained as follows.

[0063] Ostreae concha

[0064]

Base

[0065]

Original animal

[0066] 2. Long oyster O. gigas Thunberg

[0067] 3. Dalian Bay oyster O. talienwhanensis Grosse

[0068]

Harvesting and processing

[0069] Perilla leaf

[0070]

Base

[0071] [Original plant] 1. Perilla frutescens (L.) Britt. var. arguta (Benth.) Hand.-Mazz.

[0072] 2. P. frutescens (L.) Britt. var. purpurascens (Hayata) H. W. Li [P. frutescens (L.) Britt. var. acuta (Thunb.) Kudo].

[0073] [Harvesting and processing] The first one in July-September when the branches and leaves are lush, spread on the ground or hung in a well-ventilated place to dry, and then the leaves can be picked off.

[0074] Semen Cassiae

[0075] [Original plant] The mature seeds of Cassia obtusifolia L. and C. tora L. in the family Leguminosae.

[0076] [Original plant] 1. Cassia obtusifolia L.

[0077] 2. C. tora L.

[0078] [Harvesting and processing] In September-October, when the pods turn yellow-brown, the whole plant is cut and dried, and the seeds can be picked off.

[0079] Rose flower

[0080] [Original plant] The flowers of Rosa rugosa Thunb. and R. rugosa Thunb. f. plena (Regel) Byhouwer in the family Rosaceae.

[0081] [Original plant] 1. Rosa rugosa Thunb.

[0082] 2. R. rugosa Thunb. f. plena (Regel) Byhouwer

[0083] [Harvesting and processing] In May-June, before the peak flowering period, pick the fully swollen but not yet opened flower buds. Dry over low heat or air dry; or put them in paper bags and store in a lime jar, cover and replace the lime every year during the plum rain period.

[0084] Daidai flower

[0085] [Original plant] The flower buds of Citrus aurantium L. var. amara Engl. [C. aurantium cv. Daidai]

[0086] [Original plant] Citrus aurantium L. var. amara Engl. [C. aurantium cv. Daidai]

[0087] [Harvesting and Processing] In early summer, pick the bud-like flowers after the morning dew has dried on a sunny day, and dry them over a low fire.

[0088] Loquat Leaf

[0089] [Original Plant] The leaf of Eriobotrya japonica (Thunb.) Lindl [Mespilus japonica Thunb.].

[0090] [Original Plant] Eriobotrya japonica (Thunb.) Lindl [Mespilus japonica Thunb.]

[0091] [Harvesting and Processing] It can be harvested throughout the year, but mostly in June and July. After picking, dry it to 70-80% dryness, bundle it, and dry it completely. The product obtained by this method is not easy to break, and has better quality. Some people also dry the naturally fallen leaves, and the product obtained has a purplish color.

[0092] Tangerine Peel

[0093] [Original Plant] The mature pericarp of Citrus reticulata Blanco [C. nobilis lour., C. deliciosa Ten] and its cultivated varieties.

[0094] [Original Plant] 1. Citrus chachiensis Hort.

[0095] 2. Citrus reticulata Blanco.

[0096] [Harvesting and Processing] Pick the fruit when it is ripe from September to December, remove the pericarp, and dry it in the shade or under the sun.

[0097] Hawthorn Fruit

[0098] [Original Plant] The mature fruit of Crataegus pinnatifida Bunge var. major N.E. Br. and C. pinnatifida Bunge.

[0099] [Original Plant] 1. Crataegus pinnatifida Bunge var. major N.E. Br.

[0100] 2. C. pinnatifida Bunge

[0101] [Harvesting and Processing] Pick the fruit when it is ripe from September to October. Cut it into two halves horizontally or vertically while it is fresh, dry it, or cut it into thin slices using a slicing machine, and dry it at 60-65 ℃.

[0102] Raphanus Sativus

[0103] [Origin] The mature seeds of Raphanus sativus L., a plant of the genus Raphanus in the Cruciferae family.

[0104]

Original plant

[0105] [Harvesting and processing] Harvest and dry the siliques when they are fully mature from May to August of the following year after planting, remove the seeds, and store them in a dry place.

[0106] lily

[0107] [Origin] The bulbs of plants of the genus Lilium in the Liliaceae family, such as Lilium, Lilium, and Lilium truncatum.

[0108] [Original plant] 1. Lilium lanci folium Thunb.[L.tigrinum Ker-Gawl.]

[0109] 2. Lilium brownii FEBrown ex Miellez

[0110] 3. Lilium pumilum DC. [L. tenuifolium Fisch.]

[0111] Harvesting and Processing: In the second year after planting, in September or October, after the stems and leaves have withered, dig up the bulbs on a sunny day. Select the small bulbs for seeds. Wash the large bulbs and make a horizontal cut at the base to separate the scales. Then blanch them in boiling water for 5-10 minutes. When the scales soften at the edges and crack slightly on the back, quickly remove them, rinse with clean water to remove the mucus, and spread them out to dry in the sun or on a kang. Do not turn them around while they are still wet to avoid breaking them.

[0112] Gardenia

[0113] [Origin] The fruit of Gardenia jasminoides, a plant of the genus Gardenia in the Rubiaceae family.

[0114]

Original plant

[0115] Harvesting and Processing: Harvest in mid- to late October when the peel turns from green to yellow-green. Steam in a steamer or simmer in alum water, then remove and sun-dry or oven-dry. Alternatively, the fruit can be sun-dried or oven-dried directly.

[0116] citron

[0117]

Original Plant

[0118] 2. C.wilsonii Tanaka

[0119]

Harvesting and processing

[0120] The traditional Chinese medicine composition provided by the present application comprises the following components:

[0121] The conch can calm the liver and suppress the yang, and calm the nerves. The cassia seed can relieve the liver depression and improve eyesight and water. The lily can nourish the liver and kidney and soothe the liver and regulate the qi. The three components are the monarch drugs. The leaf of Chinese pear can reduce the adverse and stop vomiting, and can nourish the liver and kidney. The rose flower can regulate the liver and relieve the liver depression. The gardenia can clear away heat and remove the annoyance. The three components are the minister drugs. The hawthorn can activate the qi and disperse the stasis, and can digest the food and strengthen the stomach. The citron and the tangerine peel can regulate the qi and reduce the adverse and expand the chest and reduce the phlegm. The white radish seed can digest the food and remove the stagnation, and can reduce the qi and reduce the phlegm. The perilla leaf can activate the qi and reduce the phlegm, and can dispel the cold and relieve the exterior. The day day flower can regulate the qi and expand the chest, and can harmonize the stomach and stop vomiting. The whole prescription can relieve the liver and activate the qi, and relieve the depression and remove the annoyance.

[0122] Compared with the prior art, the present application has the following beneficial effects:

[0123] (1) The present application provides a composition for relieving the liver and relieving the depression, wherein the conch can calm the liver and suppress the yang, and calm the nerves. The cassia seed can relieve the liver depression and improve eyesight and water. The lily can nourish the liver and kidney and soothe the liver and regulate the qi. The three components are the monarch drugs. The leaf of Chinese pear can reduce the adverse and stop vomiting, and can nourish the liver and kidney. The rose flower can regulate the liver and relieve the liver depression. The gardenia can clear away heat and remove the annoyance. The three components are the minister drugs. The hawthorn can activate the qi and disperse the stasis, and can digest the food and strengthen the stomach. The citron and the tangerine peel can regulate the qi and reduce the adverse and expand the chest and reduce the phlegm. The white radish seed can digest the food and remove the stagnation, and can reduce the qi and reduce the phlegm. The perilla leaf can activate the qi and reduce the phlegm, and can dispel the cold and relieve the exterior. The day day flower can regulate the qi and expand the chest, and can harmonize the stomach and stop vomiting. The whole prescription can relieve the liver and activate the qi, and relieve the depression and remove the annoyance.

[0124] (2) The present application successfully prepares a paste for relieving the liver and relieving the depression by using the composition for relieving the liver and relieving the depression. The paste has the advantages of good taste, good storage, and no preservatives.

[0125] (3) Animal experiments show that the composition for relieving the liver and relieving the depression of the present application can better improve the anxiety of the liver depression mice and the depression symptoms of the liver depression rats.

[0126] (4) The preparation process of the composition for relieving the liver and relieving the depression and the paste of the present application is simple and easy to operate, and is beneficial to production and promotion. DETAILED DESCRIPTION

[0127] The following non-limiting examples can make those skilled in the art more fully understand the present application, but do not limit the present application in any way. The following content is only an exemplary description of the scope of the present application, and those skilled in the art can make various changes and modifications to the present application according to the disclosed content, and it should also belong to the scope of the present application.

[0128] The application will be further described in the way of specific examples. The various chemical reagents used in the examples of the application are obtained through conventional commercial channels unless otherwise stated. The amounts described below are mass amounts unless otherwise stated. Room temperature is understood to be used unless otherwise stated.

[0129] The main raw materials of the application are oyster, cassia seed, lily, loquat leaf, hawthorn, perilla leaf, rose flower, day day flower, citron, raphanus, gardenia and dried tangerine or orange peel, whose properties, tastes, meridians and functions and indications are as follows:

[0130] Oyster is salty and slightly cold. It is meridian-entering liver, gallbladder and kidney. Its functions and indications are: tranquilizing, calming the nerves, hiding yang and tonifying yin, softening and resolving. It is used for palpitation and insomnia, dizziness and tinnitus, scrofula and phlegm nodule, and mass and block.

[0131] Cassia seed is sweet, bitter and salty, and slightly cold. It is meridian-entering liver and large intestine. Its functions and indications are: clearing heat and benefiting the eyes, moistening the intestines and promoting defecation. It is used for red and painful eyes, excessive tears, headache and dizziness, and dim eyesight and constipation.

[0132] Perilla leaf is pungent and warm. It is meridian-entering lung and spleen. Its functions and indications are: dispelling wind and cold, promoting qi and harmonizing the stomach. It is used for common cold due to wind and cold, cough and vomiting, and pregnancy vomiting and fish and crab poisoning.

[0133] Rose flower is warm, sweet and slightly bitter. It is meridian-entering liver and spleen. Its functions and indications are: promoting qi and resolving stagnation, regulating blood and relieving pain. It is used for liver and stomach qi pain, poor appetite and vomiting, irregular menstruation and injury pain.

[0134] Day day flower is plain, sweet and slightly bitter. Its functions and indications are: regulating qi, relieving chest, and stimulating appetite. It is used for chest and stomach distention, nausea, and loss of appetite.

[0135] Loquat leaf is bitter and slightly cold. It is meridian-entering lung and stomach. Its functions and indications are: clearing lung and relieving cough, and descending adverse qi and stopping vomiting. It is used for lung heat and cough, adverse qi and asthma, stomach heat and vomiting, and heat and thirst.

[0136] Lily is sweet and cold. It is meridian-entering heart and lung. Its functions and indications are: nourishing yin and moistening lung, and clearing heart and calming nerves. It is used for yin deficiency and dry cough, laborious cough with blood, restlessness and palpitation, insomnia and dreaminess, and spirit in a trance.

[0137] Gardenia is bitter and cold. It is meridian-entering heart, lung and Sanjiao. Its functions and indications are: purging fire and relieving restlessness, clearing heat and dampness, and cooling blood and detoxifying; externally used for swelling and pain. It is used for heat disease with restlessness, damp-heat jaundice, strangury with pain, blood-heat hemoptysis, blood-heat eye with swelling and pain, and fire-toxin sore.

[0138] Dried tangerine or orange peel is bitter and pungent, and warm. It is meridian-entering lung and spleen. Its functions and indications are: regulating qi and invigorating spleen, and drying dampness and resolving phlegm. It is used for abdominal fullness, poor appetite and vomiting, and cough with much phlegm.

[0139] Citron sour, bitter, acid, warm. Liver, spleen, lung. Function and treatment: liver and spleen, wide, phlegm. For liver and stomach, chest pain, abdominal distension, vomiting, phlegm, cough.

[0140] Raphanus sprouts, sweet, flat. Lungs, spleen, stomach. Function and treatment: food and swelling, gas and phlegm. For food and swelling, abdominal pain, constipation, accumulation of diarrhea, phlegm, asthma and cough.

[0141] Hawthorn acid, sweet, slightly warm. Spleen, stomach, liver. Function and treatment: food and swelling, gas and phlegm, turbidity and lipid. For meat and accumulation, abdominal distension, diarrhea, abdominal pain, blood stasis, postpartum stasis, abdominal pain, chest pain, hernia pain, high blood lipids.

[0142] In the present application, the composition provided by examples 1-6 consists of the ingredients shown in table 1 (mass parts).

[0143] Table 1

[0144] Ingredients Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Oyster 20 22 18 15 25 17 Semen Cassiae 15 17 13 20 10 15 Lily 15 13 17 10 20 14 Loquat Leaf 12 9 15 17 7 16 Hawthorn 12 15 9 7 17 13 Perilla Leaf 10 8 12 5 15 12.5 Rose Flower 10 12 8 15 5 13.5 Daylily 10 12 8 15 5 6.5 Citron 10 8 12 5 15 7.5 Raphanus Sativus 8 9 7 6 10 8 Gardenia 6 5 7 8 4 7 Dried Orange Peel 6 7 5 8 4 6

[0145] The composition provided by the following comparative examples 1-5 consists of the ingredients shown in table 2 (mass parts, "-" represents not to add this ingredient).

[0146] Table 2

[0147]

[0148]

[0149] Preparation example 1

[0150] Preparation of the composition.

[0151] The composition described in examples 1-6, comparative example 1 is prepared according to the following method, as follows:

[0152] The formula amount of oyster is pretreated: washing, crushing into 2-20g size per block, drying.

[0153] The pretreated oyster, formula amount of raw material Semen Cassiae, Lily, Loquat leaf, Hawthorn, Perilla leaf, Rose flower, Daye flower, Citron, Raphanus sprouts, Gardenia, Tangerine peel are added into 7 times mass of water to decoct for 7 hours, repeated decoction 3 times, filtered, and the filtrate is collected. All the filtrate is combined, maintained at 50 DEG C and concentrated to a density of 1.33g / mL, to obtain the concentrated liquid.

[0154] The preparation method of the composition described in comparative examples 2-5 is different from the above preparation method in that the raw material ingredients and / or mass parts are different (specifically, the components of comparative examples 2-5, see table 2), and the remaining steps are the same.

[0155] Examples 1-6, Comparative Examples 1-5, the compositions prepared according to the preparation method described in Preparation Example 1 are denoted as Ae1, Ae2, Ae3, Ae4, Ae5, Ae6, Ac1, Ac2, Ac3, Ac4, Ac5, respectively.

[0156] Preparation Example 2

[0157] Preparation process of Shugan Jieyu Paste.

[0158] The process for preparing the paste using the compositions described in Examples 1-6, Comparative Example 1 as raw materials is as follows:

[0159] The prescribed amount of oyster is pretreated by washing, crushing into pieces each weighing 2-20 g, and drying.

[0160] T1, the pretreated oyster, the prescribed amount of raw medicinal materials of Cassia seed, Lily, Loquat leaf, Crataegus pinnatifida Bunge, Perilla leaf, Rosa rugosa, Daye flower, Citron, Raphanus sativus, Gardenia, and Tangerine peel are added into 7 times the amount of water and decocted for 7 hours, repeated 3 times, filtered, and the filtrate is collected. All the filtrates are combined and concentrated at 50°C to a density of 1.20 g / mL to obtain a concentrated solution.

[0161] T2, the concentrated solution prepared in step T1 is mixed and oligomaltose is added, stirred uniformly, and concentrated at 50°C to a density of 1.60 g / mL to obtain a paste. The volume-to-mass ratio of the concentrated solution to oligomaltose is 30 mL:70 g.

[0162] The process for preparing the paste using the compositions described in Comparative Examples 2-5 as raw materials is different from the above process in that the added raw medicinal material components and / or mass parts are different (specifically, the components of Comparative Examples 2-5, see Table 2), and the remaining steps are the same.

[0163] Examples 1-6, Comparative Examples 1-5, the compositions prepared according to the preparation method described in Preparation Example 2 are denoted as Be1, Be2, Be3, Be4, Be5, Be6, Bc1, Bc2, Bc3, Bc4, Bc5, respectively.

[0164] Preparation Example 3

[0165] Different from Preparation Example 2, in step T1, there is no filtering step, and the remaining steps are the same.

[0166] The Shugan Jieyu paste prepared according to the preparation process described in Preparation Example 3 using the composition described in Example 1 is denoted as Bc6.

[0167] Preparation Example 4

[0168] Different from Preparation Example 2, in step T2, the concentration at 50°C is changed to concentration at 95°C, and the remaining steps are the same.

[0169] The composition described in Example 1 was prepared by the preparation process described in Preparation Example 4 to prepare the liver-soothing and depression-relieving paste formula recorded as Bc7.

[0170] Effect evaluation

[0171] 1. Improvement of the composition on the anxiety symptoms of mice with liver-Qi stagnation

[0172] 1.1. Construction of test animal model and administration

[0173] ICR mice aged 3-4 weeks were taken and raised in stable feeding conditions for one week to adapt the mice to the environment. The mice were randomly grouped, with 10 mice in each group. A small hole was chiseled on the wall of a 50 mL plastic centrifuge tube for ventilation, and the inside of the centrifuge tube was polished flat with sandpaper to make a simple restraint device for mice. The mice were placed in the simple restraint device at a fixed time every day, the centrifuge tube cap was tightened, and the centrifuge tube was placed horizontally and fixed to keep the air hole open, so that the mice could receive 3 hours of restraint stress per day. Administration was performed 1 hour before restraint stress every day. The blank control group (mice without restraint), the negative control group (mice with restraint) were administered with 0.9% normal saline by gavage; the mice with restraint in each example and comparative example group were administered with compositions Ae1, Ae2, Ae3, Ae4, Ae5, Ae6, Ac1, Ac2, Ac3, Ac4, and Ac5 by gavage, respectively, the low-dose group was administered with crude drug amount of 3 g per kilogram of mouse body weight per day, the medium-dose group was administered with crude drug amount of 7 g per kilogram of mouse body weight per day, and the high-dose group was administered with crude drug amount of 12 g per kilogram of mouse body weight per day; the mice with restraint in the positive control group were administered with fluoxetine, with a dose of 3 mg of fluoxetine per kilogram of mouse body weight per day. The above modeling and administration process was continuously performed for 7 days.

[0174] 1.2. Behavior test

[0175] 1.2.1. Open field test

[0176] After the modeling and administration process was continuously performed for 7 days, the open field test was performed on the 8th day. The experimental device included an open field reaction box and a data acquisition and processing system. The bottom area of the open field reaction box was 1 square meter, which was divided into 4 regions, each including a peripheral region and a central region. In a quiet environment, the mice were placed in the center of the ground in the 4 regions, and the activity of the mice was recorded. The ANY-maze animal behavior analysis system was used to record the residence time of the mice in the central region within 5 minutes. After the experiment, the animals were removed, and the experimental area was sprayed with 10% ethanol to remove animal excrement and odor.

[0177] 1.2.2. Elevated plus maze test

[0178] Immediately after the open field test, the elevated plus maze test was performed. Before the test, the mice were placed in the open field for 5 min, and then the mice were placed in the center of the maze with their heads facing one of the open arms. The computer tracked and recorded the mice's activity in the elevated plus maze for 5 min. The percentage of open arm entries (OE%) and the percentage of open arm time (OT%) were used as indicators of the anti-anxiety effects of the drugs.

[0179] 1.3, Serum Corticosterone Detection

[0180] After the behavioral experiment, the mice were bled from the retro-orbital plexus, and the blood was immediately collected in a centrifuge tube. The tube was centrifuged at 5000 rpm for 5 min at 4°C, and the supernatant was collected as the test solution. The serum corticosterone content was detected using a serum corticosterone ELISA kit (Jianglai Biological, Mouse Corticosterone / Adrenosterone (CORT) ELISA Detection Kit).

[0181] 1.4, Data Processing

[0182] The data collected from the above experiments were statistically analyzed using Graph Pad Prism 8. The data were presented as mean ± standard deviation, and the comparisons between multiple groups were made using one-way ANOVA, and the pairwise comparisons were made using t-test. A p-value less than 0.05 was considered statistically significant.

[0183] 1.5, Experimental Results

[0184] The experimental results of the effect of the compositions prepared according to the preparation method of Preparation Example 1 on the central activity time of mice in Examples 1-6 and Comparative Examples 1-5 are shown in Table 3 (mean ± standard deviation, n = 10):

[0185] Table 3

[0186]

[0187] Note: Δ indicates a significant difference and p < 0.05, and ΔΔ indicates a significant difference and p < 0.01 compared with the negative control group; and Δ indicates a significant difference and p < 0.05 compared with the corresponding dose group of Ae1 (i.e., the low-dose group compared with the low-dose group of Ae1, the medium-dose group compared with the medium-dose group of Ae1, and the high-dose group compared with the high-dose group of Ae1). *

[0188] ​The results of the experiment of the effect of the compositions prepared according to the preparation method described in Preparation Example 1 of Examples 1-6 and Comparative Examples 1-5 on the percentage of open arm entries (OE%) and the percentage of open arm residence time (OT%) of mice are shown in Table 4 (average ± standard deviation, n = 10):

[0189] Table 4

[0190] Group OE / % OT / % Group OE / % OT / % Blank Control Group 42.10±4.20 46.02±4.45 Ae6 Low Dose Group [[[[ Δ 33.58±2.73]]] [[[[ Δ 38.95±4.77]]] Positive Control Group 36.07±3.33 44.46±4.10 Ae6 Medium Dose Group Δ Δ 35.19 ± 1.11 ​ <![CDATA[ Δ 37.29±4.27]]> Negative Control Group 28.24±2.83 33.70±4.98 Ae6 High Dose Group Δ Δ 36.41 ± 1.31 ​ [[[[ Δ 37.33±3.71]]] Ae1 Low Dose Group Δ Δ 37.02 ± 2.69 ​ [[[[ Δ 40.18 ± 4.40 Ac1 Low Dose Group *31.26±3.75 *31.64±2.86 Ae1 Medium Dose Group [[[[ Δ Δ 39.65 ± 4.67 [[[[ Δ 40.50 ± 3.74 Ac1 Medium Dose Group *29.82±3.04 *33.87±2.07 Ae1 High Dose Group Δ Δ 40.95 ± 1.64 ​ Δ Δ 42.50 ± 1.21 ​ Ac1 High Dose Group *30.39±4.15 *32.64±4.02 Ae2 Low Dose Group [[[ Δ Δ 38.14 ± 3.09 [[[[ Δ 38.59±4.31]]] Ac2 Low Dose Group *28.29±3.54 *29.98±3.93 Ae2 Medium Dose Group Δ Δ 38.09 ± 2.69 ​ Δ Δ 40.90 ± 1.70 ​ Ac2 Medium Dose Group *29.00±4.38 *32.18±2.77 Ae2 High Dose Group Δ Δ 41.67 ± 3.77 ​ Δ Δ 42.09 ± 2.44 ​ Ac2 High Dose Group *31.05±2.36 *32.11±1.31 Ae3 Low Dose Group Δ Δ 35.77 ± 1.82 ​ [[[[ Δ Δ 39.79 ± 3.94 Ac3 Low Dose Group *27.86±2.40 *30.94±1.51 Ae3 Medium Dose Group Δ Δ 36.76 ± 3.84 ​ Δ Δ 39.29 ± 2.26 ​ Ac3 Medium Dose Group *28.07±1.35 *33.27±1.41 Ae3 High Dose Group Δ Δ 40.09 ± 3.52 ​ Δ Δ 41.00 ± 4.27 ​ Ac3 High Dose Group *30.96±2.19 *31.52±1.56 Ae4 Low Dose Group [[[[ Δ 33.03±3.85]]] [[[5.00 Δ 38.85±3.16]]> Ac4 Low Dose Group *27.81±1.36 *30.74±4.87 Ae4 Medium Dose Group Δ Δ 35.79 ± 2.01 ​ [[[[ Δ 39.45 ± 3.36 Ac4 Medium Dose Group *29.64±1.54 *29.33±1.81 Ae4 High Dose Group Δ Δ 36.08 ± 1.18 ​ [[[5.00 Δ 39.93±3.06]]> Ac4 High Dose Group *31.43±3.51 *33.22±3.45 Ae5 Low Dose Group [[[[ Δ 33.85±2.07]]] [[[[ Δ 35.81±4.01]]] Ac5 Low Dose Group *27.18±1.34 *28.94±1.51 Ae5 Medium Dose Group [[[[ Δ 34.89±4.46]]] <![CDATA[ Δ 37.67±2.24]]> Ac5 Medium Dose Group *29.47±1.32 *28.26±1.32 Ae5 High Dose Group Δ Δ 36.62 ± 3.47 ​ [[[[ Δ 37.46±3.37]]] Ac5 High Dose Group *29.30±1.40 *30.02±3.82

[0191] Note: compared with the negative control group, Δ indicates a significant difference and p < 0.05, and ΔΔ indicates a significant difference and p < 0.01; compared with the corresponding dose group of Ae1 (i.e., the low dose group compared with the low dose group of Ae1, the medium dose group compared with the medium dose group of Ae1, and the high dose group compared with the high dose group of Ae1), Δ ΔΔ *

[0192] The results of the experiment of the effect of the compositions prepared according to the preparation method described in Preparation Example 1 of Examples 1-6 and Comparative Examples 1-5 on the serum corticosterone (CORT) of mice are shown in Table 5 (average ± standard deviation, n = 10):

[0193] Table 5:

[0194]

[0195] Note: compared with the negative control group, Δ indicates a significant difference and p < 0.05, and ΔΔ indicates a significant difference and p < 0.01; compared with the corresponding dose group of Ae1 (i.e., the low dose group compared with the low dose group of Ae1, the medium dose group compared with the medium dose group of Ae1, and the high dose group compared with the high dose group of Ae1), *

[0196] 2. Improvement of compositions on chronic stress depression symptoms in rats with liver qi stagnation

[0197] 2.1. Construction of experimental animal model and administration

[0198] Adult male Wistar rats were used as experimental animals. The blank control group was Wistar rats without treatment in the SPF level animal feeding environment. The negative control group, the positive control group, and the example and comparative example groups used model animals. The modeling method and the administration process are as follows:

[0199] ​​​​The rats were randomly divided into groups, 10 rats per group. Within 45 days, the rats were subjected to chronic stress stimulation. The rats were given one of the following stimuli randomly selected each day: 10°C cold water swimming for 5 minutes; tail clamping for 1 minute; 45° angle inclined feeding environment; water deprivation for 24 hours; food deprivation for 24 hours; wet bedding feeding. The purpose of randomly selecting the stimulation form is to make the animals unable to predict the stimulation of the next day. The rats subjected to chronic stress stimulation were given gavage daily, the negative control group was given normal saline gavage daily, the positive control group was given Jiawei Xiaoyao Pills (Tong Ren Tang, 1 g of traditional Chinese medicine per kilogram of rat body weight per day) gavage daily, and the groups of examples and comparative examples were given gavage with compositions Ae1, Ae2, Ae3, Ae4, Ae5, Ae6, Ac1, Ac2, Ac3, Ac4, and Ac5 (12 g of crude drug per kilogram of rat body weight per day) in turn. The prescription components of the Jiawei Xiaoyao Pills are Chaihu, Danggui, Baishao, Fuling, Baizhu, Gancao, Shengjiang, Bohe, Mudanpi, and Zhizi.

[0200] 2.2, Behavioral test

[0201] After 45 days of chronic stress treatment, the rats were placed in a spontaneous activity box in a quiet environment, and the number of times of crossing the line and exploring within 5 minutes was recorded as an index of autonomous activity.

[0202] 2.3, Experimental results

[0203] The effects of the compositions prepared according to the preparation method described in Preparation Example 1 on the behavior of rats in Examples 1-6 and Comparative Examples 1-5 are shown in Table 6 (mean ± standard deviation, n = 10):

[0204] Table 6

[0205]

[0206] Note: compared with the negative control group, Δ indicates a significant difference and p < 0.05, ΔΔ indicates a significant difference and p < 0.01; compared with the Ae1 corresponding dose group (i.e., the low dose group compared with the Ae1 low dose group, the medium dose group compared with the Ae1 medium dose group, and the high dose group compared with the Ae1 high dose group), * indicates a significant difference and p < 0.05.

[0207] 3, Evaluation of the taste and stability of Shuganjieyu Ointment

[0208] The soothing liver and relieving depression ointments (Be1, Be2, Be3, Be4, Be5, Be6, Bc1, Bc2, Bc3, Bc4, Bc5) prepared according to the preparation method of Preparation Example 2 from Examples 1-6 and Comparative Examples 1-5, and the soothing liver and relieving depression ointments (Bc6, Bc7) prepared according to the preparation methods of Preparation Example 3 and Preparation Example 4 from Example 1 were sealed in glass bottles and stored at 40°C for 0 days, 10 days and 30 days, respectively. An evaluation team consisting of 10 professional sensory evaluation personnel selected and trained was used to evaluate the taste and stability of the soothing liver and relieving depression ointments described above. The evaluation was performed by dissolving 20 g of each ointment in 250 mL of water at 60°C, and scoring the flavor and dissolution state (score range 0-10). The sensory evaluation indicators are shown in Table 7:

[0209] Table 7

[0210] Score Flavor Dissolution Status 10 Clear and transparent, uniform color, no precipitate, no particulate sensation General flavor, no obvious odor 5 A small amount of granular precipitate Bitter, sour, astringent or obvious odor 0 A large amount of precipitate or sandy, massive precipitate ​

[0211] The scoring results are shown in Table 8 (average values):

[0212] Table 8

[0213]

[0214] Finally, it should be noted that the above content is only used to illustrate the technical solutions of the present application, and is not a limitation on the protection scope of the present application. Simple modifications or equivalent replacements of the technical solutions of the present application made by those skilled in the art do not deviate from the essence and scope of the technical solutions of the present application.

Claims

1. A composition for soothing liver qi and relieving depression, characterized in that: The invention is prepared from the following components in parts by mass: 15-25 parts of oysters, 10-20 parts of cassia seeds, 10-20 parts of lilies, 7-17 parts of loquat leaves, 7-17 parts of hawthorns, 5-15 parts of perilla leaves, 5-15 parts of roses, 5-15 parts of daisy flowers, 5-15 parts of citrons, 6-10 parts of radish seeds, 4-8 parts of gardenias, and 4-8 parts of dried tangerine peels; the mass ratio of the roses to the daisy flowers is 1:1; the mass ratio of the perilla leaves to the citron is 1:

1.

2. The composition according to claim 1, characterized in that The invention is prepared from the following components by mass: 18-22 parts of oyster, 13-17 parts of cassia seed, 13-17 parts of lily, 9-15 parts of loquat leaf, 9-15 parts of hawthorn, 8-12 parts of perilla leaf, 8-12 parts of rose, 8-12 parts of daikon radish, 8-12 parts of citron, 7-9 parts of radish seed, 5-7 parts of gardenia and 5-7 parts of dried tangerine peel.

3. The composition according to claim 2, characterized in that The invention is prepared from the following components by mass: 20 parts of oyster, 15 parts of cassia seed, 15 parts of lily, 12 parts of loquat leaf, 12 parts of hawthorn, 10 parts of perilla leaf, 10 parts of rose, 10 parts of daisy flower, 10 parts of citron, 8 parts of radish seed, 6 parts of gardenia and 6 parts of dried tangerine peel.

4. The composition according to claim 1, characterized in that The rose flower is a dried bud of a double-petal rose.

5. The method for preparing the composition according to any one of claims 1 to 4, characterized in that: The following steps are involved: Mix oyster, cassia seed, lily, loquat leaf, hawthorn, perilla leaf, rose flower, daikon radish flower, citron, radish seed, gardenia fruit and tangerine peel with water, decoct, filter, collect the filtrate, and concentrate to obtain a concentrate.

6. The preparation method according to claim 5, characterized in that: The oysters are pretreated before decocting; the decocting is performed 2-3 times, with 6-8 times the mass of water added each time, and the decocting is performed for 5-8 hours; and the concentration is performed to a density of 1.20-1.40 g / mL.

7. A medicine for soothing liver qi and relieving depression, characterized in that: The raw material is the composition according to any one of claims 1 to 4 or the composition prepared by the preparation method according to any one of claims 5 to 6.

8. The medicine according to claim 7, characterized in that The drug also includes pharmaceutically acceptable excipients.

9. The medicine according to claim 7, characterized in that The dosage form of the drug is selected from pills, capsules, granules, oral liquids, powders, tablets, lozenges, and syrups.

10. A paste prescription for soothing liver qi and relieving depression, characterized in that: The composition is made of raw materials and auxiliary materials, wherein the raw materials are the composition according to any one of claims 1 to 4, and the auxiliary materials are at least one selected from maltooligosaccharide, isomaltooligosaccharide, crystal sugar and honey.

11. The paste prescription according to claim 10, characterized in that: The auxiliary material is isomaltooligosaccharide.

12. The method for preparing the paste prescription according to claim 10 or claim 11, characterized in that: The following steps are involved: T1. Mix oyster, cassia seed, lily, loquat leaf, hawthorn, perilla leaf, rose flower, daikon radish flower, citron, radish seed, gardenia fruit, and tangerine peel with water, decoct, filter, collect the filtrate, and concentrate to obtain a concentrate; T2. Mix the concentrated solution prepared in step T1 with the auxiliary materials, stir and concentrate to obtain a paste formula.

13. The preparation method according to claim 12, characterized in that: In step T1, the decoction is performed 2-3 times, 6-8 times the mass of water is added each time, and the decoction is performed for 5-8 hours. The concentration is performed to a density of 1.20-1.40 g / mL.

14. The preparation method according to claim 12, characterized in that: In step T2, the volume mass ratio of the concentrated solution to the auxiliary material is 20-40 mL:55-85 g, and the concentration is carried out at 40-60° C. to a density of 1.41-1.65 g / mL.

15. Use of the composition according to any one of claims 1 to 4, or the composition obtained by the preparation method according to any one of claims 5 to 6, or the medicine according to any one of claims 7 to 9, or the paste according to any one of claims 10 to 11, or the paste obtained by the preparation method according to any one of claims 12 to 14 in preparing products for soothing the liver and relieving depression.

16. The use according to claim 15, characterized in that The product is a traditional Chinese medicine or a food.

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